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Lesions in the lungs of fatal corona virus disease Covid-19.
- Source :
- Annals of Anatomy; Mar2021, Vol. 234, pN.PAG-N.PAG, 1p
- Publication Year :
- 2021
-
Abstract
- The corona virus outbreak in Wuhan, China, at the end of 2019 has rapidly evolved into a pandemic which is still virulent in many countries. An infection with SARS-CoV-2 can lead to corona virus disease (Covid-19). This paper presents an overview of the knowledge gained so far with regard to histopathological lung lesions in fatal courses of Covid-19. The main findings were diffuse alveolar damage and micro-angiopathies. These included the development of hyaline membranes, thrombi, endothelial inflammation, haemorrhages and angiogenesis. Overall, the vessel lesions seemed to be more lethal than the diffuse alveolar damage. There was obvious hyperreactivity and hyperinflammation of the cellular immune system. An expanded T-cell memory may explain the increased risk of a severe course in the elderly. [ABSTRACT FROM AUTHOR]
- Subjects :
- VIRUS diseases
CORONAVIRUSES
COVID-19
SARS-CoV-2
LUNGS
GLYCOCALYX
Subjects
Details
- Language :
- English
- ISSN :
- 09409602
- Volume :
- 234
- Database :
- Supplemental Index
- Journal :
- Annals of Anatomy
- Publication Type :
- Academic Journal
- Accession number :
- 148284464
- Full Text :
- https://doi.org/10.1016/j.aanat.2020.151657