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55 results on '"Perini, Tommaso"'

51. Early and Profound Exhausted Phenotype of Central Memory and Memory Stem T Cells in the Bone Marrow of AML Patients Characterizes and Predicts Relapse after Allo-HSCT

Author

Noviello, Maddalena, Manfredi, Francesco, Perini, Tommaso, Giacomo, Oliveira, Cortesi, Filippo, De Simone, Pantaleo, Toffalori, Cristina, Gambacorta, Valentina, Bondanza, Attilio, Greco, Raffaella, Peccatori, Jacopo, Casorati, Giulia, Dellabona, Paolo, Cieri, Nicoletta, Vago, Luca, Ciceri, Fabio, and Bonini, Chiara

Abstract

Background: Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) is the only cure for high-risk acute myeloid leukemia (AML). Unfortunately, relapse remains the major cause of death after HSCT. We investigated if T-cell dysfunction is associated to post-transplant relapse.

Published
2017
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52. Bone Marrow Microenvironment Induces Genomic Instability and Enables Clonal Evolution in Multiple Myeloma

Author

Perini, Tommaso, Szalat, Raphael, Fulciniti, Mariateresa, Samur, Mehmet Kemal, Lopez, Michael A, Nanjappa, Puru, Wen, Kenneth, Li, Na, Xu, Yan, Tai, Yu-Tzu, Shammas, Masood A., Anderson, Kenneth C, Ciceri, Fabio, and Munshi, Nikhil

Abstract

Multiple myeloma (MM) is characterized by ongoing DNA damage and genomic instability, with acquisition of mutations and structural changes during disease progression. Its growth and survival charactersitics are also affected by the bone marrow (BM) microenvironment, influencing its pathogenesis as well as development of drug resistance. However, it is unclear whether the BM microenvironment can affect the ability of the tumor cells to acquire new genomic changes. The susceptibility to genomic changes might come from an increase in the endogenous sources of DNA damage or an impairment or deregulation of the DNA Damage Response (DDR). We hypothesized that the microenvironment may also contribute to ongoing DNA damage and genomic instability in MM.

Published
2017
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53. Direct Costs in 4-Years Post Allogeneic Transplant Follow-up: A Comparative Analysis of 15 Matched Patients with and without GvHD

Author

Lupo Stanghellini, Maria Teresa, Xue, Elisabetta, Greco, Raffaella, Guggiari, Elena, Assanelli, Andrea, Mannina, Daniele, Marktel, Sarah, Marcatti, Magda, Carrabba, Matteo Giovanni, Lunghi, Francesca, Morelli, Mara, Perini, Tommaso, Casirati, Gabriele, Messina, Carlo, Piemontese, Simona, Giglio, Fabio, Vago, Luca, Bernardi, Massimo, Corti, Consuelo, Peccatori, Jacopo, and Ciceri, Fabio

Abstract

Background

Published
2017
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54. Posttransplantation cyclophosphamide and sirolimus for prevention of GVHD after HLA-matched PBSC transplantation

Author

Fabio Giglio, Daniele Mannina, Andrea Assanelli, Serena Dalto, Consuelo Corti, Massimo Bernardi, Jacopo Peccatori, Sara Mastaglio, Fabio Ciceri, Mara Morelli, Tommaso Perini, Lorenzo Lazzari, Simona Piemontese, Francesca Lorentino, Maria Teresa Lupo Stanghellini, Raffaella Greco, Magda Marcatti, Greco, Raffaella, Lorentino, Francesca, Morelli, Mara, Giglio, Fabio, Mannina, Daniele, Assanelli, Andrea, Mastaglio, Sara, Dalto, Serena, Perini, Tommaso, Lazzari, Lorenzo, Piemontese, Simona, Corti, Consuelo, Marcatti, Magda, Bernardi, Massimo, Lupo Stanghellini, Maria Teresa, Ciceri, Fabio, and Peccatori, Jacopo

Subjects
Oncology, Adult, Male, medicine.medical_specialty, Transplantation Conditioning, Cyclophosphamide, Immunology, Graft vs Host Disease, PBSC transplantation, Human leukocyte antigen, Disease, Biochemistry, Chemoprevention, 03 medical and health sciences, 0302 clinical medicine, immune system diseases, In vivo, Internal medicine, Medicine, Humans, Nonrelapse mortality, Aged, Sirolimus, Peripheral Blood Stem Cell Transplantation, business.industry, Histocompatibility Testing, Cell Biology, Hematology, Middle Aged, surgical procedures, operative, 030220 oncology & carcinogenesis, Hematologic Neoplasms, Female, business, 030215 immunology, medicine.drug
Abstract

To the editor: Graft-versus-host disease (GVHD), both acute and chronic, is still a leading cause of nonrelapse mortality after transplantation.[1][1] High-dose, posttransplantation cyclophosphamide (PTCy) is an attractive approach for in vivo allodepletion across the HLA barrier in allogeneic

Published
2016

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