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BackgroundAlthough many young Chinese women migrate to urban regions for better opportunities, little is known about the prevalence and awareness of having high blood pressure (HBP) in this population. This study investigated the prevalence, awareness, and factors associated with HBP among young female migrant workers in Central South China.MethodsWe conducted a cross-sectional study to identify HBP (2017 ACC/AHA guidelines) among female migrant workers aged 18-45 years in Central South China. Demographics, anthropometric measurements, hypertension-related lifestyle, awareness of HBP, and blood pressure were recorded. Logistic regression analysis was used to identify the factors associated with HBP (blood pressure ≥ 130/80 mmHg).ResultsOverall, 232 female migrants participated in the study (mean age 34.4; standard deviation: 6.4 years). The prevalence of HBP was 27.2% (95% CI [21.6-33.2]), and 88.9% of the participants were unaware of their HBP status. Having rural medical insurance (odds ratio [OR] = 20.7; 95% confidence interval 95% CI [2.1-204.8]), awareness of having HBP (OR = 5.1; 95% CI [1.4-18.5]), physical inactivity (OR = 2.9; 95% CI [1.1-7.9]), and being overweight/obese (OR = 2.7; 95% CI [1.3-6.1]) were independently associated with HBP.ConclusionsThis study revealed a high prevalence of HBP among young Chinese female migrant workers, as well as a high frequency of being unaware of their condition and some associated factors (rural medical insurance, awareness of having HBP, physical inactivity, and overweight/obesity). The uncontrolled HBP among young Chinese female migrant workers suggested that health education needs further promotion in such a population.

With the rapid development of electric vehicles (EVs) in Chinese cities, accurately forecasting the number of EVs used by urban residents in the next five years and more long term is beneficial for the government to adjust industrial policies of EVs, guide the rational planning of urban charging facilities and supporting distribution network, and achieve the rational and orderly development of the EV industry. The paper considers the advantages of using the grey GM(1,1) prediction model to predict the short-term ownership of EVs by urban residents. Then, by forecasting the number of EV users in a certain city in the future and predicting the number of private vehicles in the future, the boundary conditions for long-term year ownership of EVs by residents are determined. Combined with historical data and short-term forecast data generated by the grey prediction model, the model parameters that include the innovation coefficient and imitation coefficient of the Bass model are trained using a genetic algorithm. Finally, the Bass model is used for medium- to long-term ownership forecasting from 2023 to 2040. The prediction error for the target year is provided. The simulation results indicate that the ownership of resident EVs in this city will experience rapid growth in the next five years.

This paper briefly describes the theoretical basis of the DRY-1B capacitive component drilling strain gauge (drilling strain gauge). It discusses critical technologies such as micro-displacement sensing, noise reduction, temperature control, performance testing, and calibration. The strain gauge achieved high resolution (≥5×10−11ε), wideband (10–100 Hz optional), extensive dynamic range (≥1×10−3ε), 24-bit AD recording, low power consumption (< 3W), and other technical indicators. Its performance is better than the United States PBO and Japan borehole strain gauge of the same period, and it is an international leading long-term observation instrument for crustal movement, which can basically meet the observation requirements of creep movement with slow accumulation of long-term strain and seismic and volcanic activity with a rapid change of short-term strain. Since 2008, through the application of more than 20 geostress stations, the borehole strain gauge has recorded a large amount of strain information, such as crustal deformation, fault activity, co-seismic strain wave, strain step, and ore pressure activity. Based on the results of the self-consistency test of strain monitoring data of the geostress station in the Beichangshan Mountain and the analysis of seismic mapping capacity of the Turkey earthquake, it is found that the strain curves of the 1#+3# and 2#+4# capacitance sensors at the Beichangshan Mountain stress station are generally stable, and the correlation coefficient R2 is 0.95. The annual variation rate of the differential strain of 1#–3# and 2#–4# elements is 10−8 magnitude, which reflects that the shear stress is dominant in the Long Island area and the stress environment of seismic activity is relatively high. The strain gauge was used to observe the apparent co-seismic strain response of Turkey’s M 7.8 and M 7.5 earthquakes on February 6, 2023. In particular, it obtained the M 7.8 main seismic surface wave period of 50–60 s, presenting an out-facing wave anomaly. Theoretically, the strain wave generated by the M 0.74 earthquakes within 100 km can be distinguished, and the application demonstration effect has been achieved. The borehole strain gauge has good popularization value and application prospects in geodynamics research and internal dynamic geological disaster monitoring.

The article reviews the development of the volumetric borehole strain gauge. In response to the current problems of insufficient stability and bandwidth and low calibration accuracy of the volumetric strain gauge, a TY-2B-type small volumetric borehole strain gauge was developed with innovative improvements in the hydraulic sensor, control circuit, and calibration method. The improved hydraulic sensor improves the accuracy and reduces the instrument’s volume; the improved control circuit increases the sampling rate, bandwidth, and the instrument’s stability; the innovative piezoelectric ceramic calibration technology raises the reliability of the monitoring data. The test results show that the improved TY-2B volumetric strain gauge has a low power consumption of less than 3 W, good long-term stability, high sensitivity with a resolution of 10-11 ε, and suitable high-frequency and low-frequency. It has a sampling rate of 100 Hz and can acquire complete seismic strain waveforms with precise and stable solid tide waveforms. It is small and light, with a reduced outer diameter of Φ89 mm for Φ100 mm drilling, a length of 1300 mm, and a weight of 45 kg for easy transport and installation. After 15 years of laboratory and field station testing, it obtained good monitoring data and demonstrated its highly sensitive seismic reflection capability. The observed response of the volumetric strain station in the northern section of Longmen Mountain to the 2010 Yushu earthquake and the 2023 Turkey earthquake shows that the TY-series high-precision volumetric strain gauge is not only a static strain gauge but also a broad-frequency strain seismograph with dynamic-static calibration capability. It has a unique advantage over pendulum seismometers in that it can observe both the long-term slow deformation and accumulation of deformation in the earth’s crust and the transient subtle features of crustal rupture and deformation. The long-term trends of the monitoring curves obtained from the Qingchuan–Hanzhong volumetric strain stations since the Wenchuan earthquake and the Guangzhou station since 2021 are consistent with the regional geological characteristics reflected by the seismic and tectonic geological data, indicating that the TY-2B volumetric strain gauge can meet the needs of geological scientific research and geological hazard observation.

In order to obtain the in-situ stress field characteristics and analyze tectonic stability in the Motuo key area of the eastern Himalayan syntaxis, the in-situ stress measurement of one in-situ stress hole and 11 test sections of the Xirang section of the Motuo fault zone were carried out by the hydraulic fracturing method. The results show that the maximum and minimum horizontal principal stress values (SH, Sh) in the test section of 61.43−121.34 m are 3.05−14.50 MPa and 2.16−9.87 MPa, respectively, and the vertical principal stress values (Sv) are 1.63−3.31 MPa, namely, SH>Sh>Sv. The in-situ stress field at the measuring point is dominated by horizontal compression, and all of them belong to the in-situ stress state of reverse fault. The principal stress values gradually increase with the increase of depth, and the dominant direction of the maximum principal stress is NEE. In the whole range of in-situ stress depth, the lateral pressure coefficients (Kav) are 1.39−4.38, the maximum horizontal stress coefficients (KHv) are greater than 1, and the ratio increases with the increase of depth. The regional stress field of this key area is dominated by horizontal stress and it is highly directional. The horizontal stress coefficients (KHh) of all test sections are 1.23−1.66, which are similar to the calculation results of in-situ stress characteristic parameters in Linzhi−Tongmai section. The horizontal tectonic stress of the shallow level at 98 m is relatively small, and the stress accumulation level is low. The friction coefficient required to maintain fault stability is smaller than the critical friction coefficient of actual fault, and the tectonic environment is relatively stable. When the depth exceeds 98 m, the friction coefficient required to maintain fault stability is close to the critical friction coefficient value of the actual fault due to the dominant role of horizontal tectonic stress, and there is a small risk of fault instability slip. The superposition of the Coulomb stress change in the sinistral strike-slip direction and the thrust direction caused by the strong regional earthquakes on the fault plane of the Motuo fault zone in the study area are all negative numbers, which inhibits fault slip and does not increase the risk of fault activity in the study area.

Abstract Background Histone modification is an important epigenetic regulatory mechanism and essential for stress adaptation in plants. However, systematic analysis of histone modification genes (HMs) in Brassicaceae species is lacking, and their roles in response to abiotic stress have not yet been identified. Results In this study, we identified 102 AtHMs, 280 BnaHMs, 251 BcHMs, 251 BjHMs, 144 BnHMs, 155 BoHMs, 137 BrHMs, 122 CrHMs, and 356 CsHMs in nine Brassicaceae species, respectively. Their chromosomal locations, protein/gene structures, phylogenetic trees, and syntenies were determined. Specific domains were identified in several Brassicaceae HMs, indicating an association with diverse functions. Syntenic analysis showed that the expansion of Brassicaceae HMs may be due to segmental and whole-genome duplications. Nine key BnaHMs in allotetraploid rapeseed may be responsible for ammonium, salt, boron, cadmium, nitrate, and potassium stress based on co-expression network analysis. According to weighted gene co-expression network analysis (WGCNA), 12 BnaHMs were associated with stress adaptation. Among the above genes, BnaPRMT11 simultaneously responded to four different stresses based on differential expression analysis, while BnaSDG46, BnaHDT10, and BnaHDA1 participated in five stresses. BnaSDG46 was also involved in four different stresses based on WGCNA, while BnaSDG10 and BnaJMJ58 were differentially expressed in response to six different stresses. In summary, six candidate genes for stress resistance (BnaPRMT11, BnaSDG46, BnaSDG10, BnaJMJ58, BnaHDT10, and BnaHDA1) were identified. Conclusions Taken together, these findings help clarify the biological roles of Brassicaceae HMs. The identified candidate genes provide an important reference for the potential development of stress-tolerant oilseed plants.

Abstract Haemoglobin E (HbE) β-thalassaemia causes approximately 50% of all severe thalassaemia worldwide; equating to around 30,000 births per year. HbE β-thalassaemia is due to a point mutation in codon 26 of the human HBB gene on one allele (GAG; glutamatic acid → AAG; lysine, E26K), and any mutation causing severe β-thalassaemia on the other. When inherited together in compound heterozygosity these mutations can cause a severe thalassaemic phenotype. However, if only one allele is mutated individuals are carriers for the respective mutation and have an asymptomatic phenotype (β-thalassaemia trait). Here we describe a base editing strategy which corrects the HbE mutation either to wildtype (WT) or a normal variant haemoglobin (E26G) known as Hb Aubenas and thereby recreates the asymptomatic trait phenotype. We have achieved editing efficiencies in excess of 90% in primary human CD34 + cells. We demonstrate editing of long-term repopulating haematopoietic stem cells (LT-HSCs) using serial xenotransplantation in NSG mice. We have profiled the off-target effects using a combination of circularization for in vitro reporting of cleavage effects by sequencing (CIRCLE-seq) and deep targeted capture and have developed machine-learning based methods to predict functional effects of candidate off-target mutations.

In this work, we calculated the lattice thermal conductivity of monolayer InTe by means of phonon Boltzmann transport theory with first-principles calculated inter-atomic force constants. The higher-order phonon anharmonicity was found to play a strong impact on thermal transport in InTe. With the involvement of the phonon–phonon scattering process up to the fourth-order, the in-plane lattice thermal conductivity of monolayer InTe is 5.1 W m−1 K−1 at room temperature, which is 35% of that considering only third-order force constants. Furthermore, strain was found to be an effective way to manipulate the thermal transport in InTe, which reduces to one half when applying 5% in-plane tensile strain. The strain adjustment is due to the decreases in the phonon group velocity as well as the increase in the phonon scattering rates. These findings can enrich thermal transport properties of group-III monochalcogenides and benefit the material design of thermoelectrics and thermal management electronic devices. [ABSTRACT FROM AUTHOR]

With the implementation of the Law on Doctors of the People's Republic of China on March 1, 2022, off-label use of drugs has been included into the legislation for the first time. The Law on Doctors of the People's Republic of China stipulates: 'In the absence of effective or better treatment approaches and other special circumstances, after obtaining the informed consent of the patient/guardian/entrusted agent, the clinician can undertake a usage not specified in the drug instruction if supported with evidence. Medical institutions are suggested to establish a management system to review the suitability of prescriptions and medications and strictly standardize the medication behavior of clinicians'. In view of this, Peking Union Medical College Hospital has established the management system for off-label drug use based on evidence-based methods, with the aim to strengthen its management and rational use in our hospital. The measures for off-label drug use have been formulated to safeguard the doctors' legitimate rights, as well as to strictly standardize practicing behavior. Contingency plans have been established for risk prevention and control to protect the patients' rights and escort the off-label use of drugs. Hierarchical management based on the patients' needs and the types of evidence sources for off-label medication use have been adopted to improve its feasibility.

AIM: To quantitatively analyze the changes of retinal microcirculation in patients with pregnancy-induced hypertension(PIH)syndrome who have delivered after more than 6mo by using optical coherence tomography angiography(OCTA).METHODS: In this study, a total of 19 females with PIH, 23 healthy pregnant women and 19 control non pregnant women(CNPW)were recruited. Ocular examinations including diopter, best corrected visual acuity and axial length were measured, respectively. OCTA was used to measure the optic nerve head and macular blood flow parameters, nerve fiber layer and choroidal thickness of the three groups. The data of pregnant patients were collected more than 6mo after delivery. All statistical analyses were performed in the SPSS20.0, and single factor analysis of variance was used to analyze inter-group differences of retinal microcirculation related parameters among the three groups.RESULTS: Foveal avascular zone(FAZ)of the PIH group was significantly larger than that of the HPW and CNPW groups(all P