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919 results on '"Pauls, David"'

52. Social anxiety in parents of high-functioning children with autism and Asperger syndrome

Author

Kuusikko-Gauffin, Sanna, Pollock-Wurman, Rachel, Mattila, Marja-Leena, Jussila, Katja, Ebeling, Hanna, Pauls, David, and Moilanen, Irma

Subjects
Parents -- Health aspects -- Social aspects, Asperger syndrome -- Risk factors -- Research, Social phobia -- Causes of, Health
Abstract

We evaluated social anxiety (SA) symptoms in parents of children with autism spectrum disorders (ASDs; N = 131) and community parents (N = 597) using the Social Phobia and Anxiety [...]

Published
2013
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54. Valence Scaling of Dynamic Facial Expressions is Altered in High-Functioning Subjects with Autism Spectrum Disorders: an fMRI Study

Author

Rahko, Jukka S., Paakki, Jyri-Johan, Starck, Tuomo H., Nikkinen, Juha, Pauls, David L., Kätsyri, Jari V., Jansson-Verkasalo, Eira M., Carter, Alice S., Hurtig, Tuula M., Mattila, Marja-Leena, Jussila, Katja K., Remes, Jukka J., Kuusikko-Gauffin, Sanna A., Sams, Mikko E., Bölte, Sven, Ebeling, Hanna E., Moilanen, Irma K., Tervonen, Osmo, and Kiviniemi, Vesa

Published
2012
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55. Sex-specific clinical correlates of hoarding in obsessive-compulsive disorder

Author

Samuels, Jack F., Bienvenu, O. Joseph, Pinto, Anthony, Murphy, Dennis L., Piacentini, John, Rauch, Scott L., Fyer, Abby J., Grados, Marco A., Greenberg, Benjamin D., Knowles, James A., McCracken, James T., Cullen, Bernadette, Riddle, Mark A., Rasmussen, Steven A., Pauls, David L., Liang, Kung-Yee, Hoehn-Saric, Rudolf, Pulver, Ann E., and Nestadt, Gerald

Published
2008
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59. Further development of YBOCS dimensions in the OCD Collaborative Genetics Study: Symptoms vs. categories

Author

Pinto, Anthony, Greenberg, Benjamin D., Grados, Marco A., Bienvenu, O. Joseph, III, Samuels, Jack F., Murphy, Dennis L., Hasler, Gregor, Stout, Robert L., Rauch, Scott L., Shugart, Yin Y., Pauls, David L., Knowles, James A., Fyer, Abby J., McCracken, James T., Piacentini, John, Wang, Ying, Willour, Virginia L., Cullen, Bernadette, Liang, Kung-Yee, Hoehn-Saric, Rudolf, Riddle, Mark A., Rasmussen, Steven A., and Nestadt, Gerald

Published
2008
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62. L-histidine decarboxylase and Tourette's syndrome

Author

Ercan-Sencicek, A. Gulhan, Stillman, Althea A., Ghosh, Ananda K., Bilguvar, Kaya, O'Roak, Brian J., Mason, Christopher E., Abbott, Thomas, Gupta, Abha, King, Robert A., Pauls, David L., Tischfield, Jay A., Heiman, Gary A., Singer, Harvey S., Gilbert, Donald L., Hoekstra, Pieter J., Morgan, Thomas M., Loring, Erin, Yasuno, Katsuhito, Fernandez, Thomas, Sanders, Stephan, Louvi, Angeliki, Cho, Judy H., Mane, Shrikant, Colangelo, Christopher M., Biederer, Thomas, Lifton, Richard P., Gunel, Murat, and State, Matthew W.

Subjects
Decarboxylases -- Genetic aspects, Gene mutations -- Analysis, Histidine -- Research, Tourette's syndrome -- Genetic aspects, Tourette's syndrome -- Diagnosis, Tourette's syndrome -- Care and treatment
Abstract

An analysis of linkage in a two-generation pedigree leading to the identification of a rare functional mutation in the HDC gene encoding L-histidine decarboxylase and Tourette's syndrome, the rate-limiting enzyme in histamine biosynthesis is described. The study findings along with the published data from model system provide insight into the role for histaminergic neurotransmission in the mechanism and modulation of Tourette's syndrome and tics.

Published
2010

64. Clinical correlates and genetic linkage of social and communication difficulties in families with obsessive–compulsive disorder: Results from the OCD Collaborative Genetics Study

Author

Samuels, Jack, Shugart, Yin Yao, Wang, Ying, Grados, Marco A., Bienvenu, Joseph O., Pinto, Anthony, Rauch, Scott L., Greenberg, Benjamin D., Knowles, James A., Fyer, Abby J., Piacentini, John, Pauls, David L., Cullen, Bernadette, Rasmussen, Steven A., Stewart, Evelyn S., Geller, Dan A., Maher, Brion S., Goes, Fernando S., Murphy, Dennis L., McCracken, James T., Riddle, Mark A., and Nestadt, Gerald

Published
2014
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70. Disruption of neurexin 1 associated with autism spectrum disorder

Author

Hyung-Goo Kim, Kishikawa, Shotaro, Higgins, Anne W., Ihn-Sik Seong, Donovan, Diana J., Yiping Shen, Lally, Eric, Weiss, Lauren A., Najm, Juliane, Kutsche, Kerstin, Descartes, Maria, Holt, Lynn, Braddock, Stephen, Troxell, Robin, Kaplan, Lee, Volkmar, Fred, Klin, Ami, Tsatsanis, Katherine, Harris, David J., Noens, Ilse, Pauls, David L., Daly, Mark J., MacDonald, Marcy E., Morton, Cynthia C., Quade, Bradley J., and Gusella, James F.

Subjects
Autism -- Genetic aspects, Chromosome abnormalities -- Health aspects, Genetic disorders -- Research, Biological sciences
Abstract

Two independent subjects that display an autism spectrum disorder (ASD) in association with a balanced chromosomal abnormality involving 2p16.3 are studied to implicate the neurexin 1 (NRXN1) gene. It is suggested that subtle changes in NRXN1 contribute to susceptibility to ASD.

Published
2008

72. Hoarding in obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study

Author

Samuels, Jack F, Bienvenu, O. Joseph, III., Pinto, Anthony, Fyer, Abby J., McCracken, James T., Rauch, Scott L., Murphy, Dennis L., Grados, Marco A., Greenberg, Benjamin D., Knowles, James A., Piacentini, John, Cannistraro, Paul A., Cullen, Bernadette, Riddle, Mark A., Rasmussen, Steven A., Pauls, David L., Willour, Virginia L., Shugart, Yin Y., Liang, Kung-yee, Hoehn-Saric, Rudolf, and Nestadt, Gerald

Subjects
Compulsive hoarding -- Risk factors, Compulsive hoarding -- Social aspects, Obsessive-compulsive disorder -- Research, Psychology and mental health
Abstract

Hoarding behavior occurs frequently in obsessive--compulsive disorder (OCD). Results from previous studies suggest that individuals with OCD who have hoarding symptoms are clinically different than non-hoarders and may represent a distinct clinical group. In the present study, we compared 235 hoarding to 389 non-hoarding participants, all of whom had OCD, collected in the course of the OCD Collaborative Genetics Study. We found that, compared to non-hoarding individuals, hoarders were more likely to have symmetry obsessions and repeating, counting, and ordering compulsions; poorer insight; more severe illness; difficulty initiating or completing tasks; and indecision. Hoarders had a greater prevalence of social phobia and generalized anxiety disorder. Hoarders also had a greater prevalence of obsessive--compulsive and dependent personality disorders. Five personality traits were independently associated with hoarding: miserliness, preoccupation with details, difficulty making decisions, odd behavior or appearance, and magical thinking. Hoarding and indecision were more prevalent in the relatives of hoarding than of non-hoarding probands. Hoarding in relatives was associated with indecision in probands, independently of proband hoarding status. The findings suggest that hoarding behavior may help differentiate a distinct clinical subgroup of people with OCD and may aggregate in some OCD families. Indecision may be a risk factor for hoarding in these families. Keywords: Hoarding: Obsessive--compulsive disorder; Comorbidity; Personality

Published
2007

73. A genetic family-based association study of OLIG2 in obsessive-compulsive disorder

Author

Stewart, S. Evelyn, Platko, Jill, Fagerness, Jesen, Birns, Julie, Jenike, Eric, Smoller, Jordan W., Perlis, Roy, Leboyer, Marion, Delorme, Richard, Chabane, Nadia, Rauch, Scott L., Jenike, Michael A., and Pauls, David L.

Subjects
Obsessive-compulsive disorder -- Research, Obsessive-compulsive disorder -- Genetic aspects, Obsessive-compulsive disorder -- Causes of, Brain -- Research, Brain -- Physiological aspects, Genetic markers -- Usage, Health, Psychology and mental health
Published
2007

75. A controlled family study of attention-deficit/hyperactivity disorder and Tourette's disorder

Author

Stewart, S. Evelyn, Illmann, Cornelia, Geller, Daniel A., Leckman, James F., King, Robert, and Pauls, David L.

Subjects
Attention-deficit hyperactivity disorder -- Research, Attention-deficit hyperactivity disorder -- Causes of, Attention-deficit hyperactivity disorder -- Genetic aspects, Tourette's syndrome -- Research, Tourette's syndrome -- Causes of, Tourette's syndrome -- Genetic aspects, Family and marriage, Psychology and mental health
Published
2006

78. Autism

Author

Volkmar, Fred R. and Pauls, David

Published
2003

79. Prospective study of prodromal features for bipolarity in well Amish children

Author

Egeland, Janice A., Shaw, Jon A., Endicott, Jean, Pauls, David L., Allen, Cleona R., Hostetter, Abram M., and Sussex, James N.

Subjects
Amish -- Psychological aspects, Amish -- Health aspects, Bipolar disorder -- Diagnosis, Symptomatology -- Diagnosis, Child psychiatry -- Research, Family and marriage, Psychology and mental health
Published
2003

80. Epigenetic abnormalities associated with a chromosome 18(q21-q22)inversion and a Gilles de la Tourette syndrome phenotype

Author

State, Matthew W., Greally, John M., Cuker, Adam, Bowers, Peter N., Henegariu, Octavian, Morgan, Thomas M., Gunel, Murat, DiLuna, Michael, King, Robert A., Nelson, Carol, Donovan, Abigail, Anderson, George M., Leckman, James F., Hawkins, Trevor, Pauls, David L., Lifton, Richard P., and Ward, David C.

Subjects
Extrapyramidal disorders -- Genetic aspects, Science and technology
Abstract

Gilles de la Tourette syndrome (GTS) is a potentially debilitating neuropsychiatric disorder defined by the presence of both vocal and motor tics. Despite evidence that this and a related phenotypic spectrum, including chronic tics (CT) and Obsessive Compulsive Disorder (OCD), are genetically mediated, no gene involved in disease etiology has been identified. Chromosomal abnormalities have long been proposed to play a causative role in isolated cases of GTS spectrum phenomena, but confirmation of this hypothesis has yet to be forthcoming. We describe an i(18q21.1-q22.2) inversion in a patient with CT and OCD. We have fine mapped the telomeric aspect of the rearrangement to within 1 Mb of a previously reported 18q22 breakpoint that cosegregated in a family with GTS and related phenotypes. A comprehensive characterization of this genomic interval led to the identification of two transcripts, neither of which was found to be structurally disrupted. Analysis of the epigenetic characteristics of the region demonstrated a significant increase in replication asynchrony in the patient compared to controls, with the inverted chromosome showing delayed replication timing across at least a 500-kb interval. These findings are consistent with long-range functional dysregulation of one or more genes in the region. Our data support a link between chromosomal aberrations and epigenetic mechanisms in GTS and suggest that the study of the functional consequences of balanced chromosomal rearrangements is warranted in patients with phenotypes of interest, irrespective of the findings regarding structurally disrupted transcripts.

Published
2003

89. Comprehensive family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder

Author

Samuels, Jack, Wang, Ying, Riddle, Mark A., Greenberg, Benjamin D., Fyer, Abby J., McCracken, James T., Rauch, Scott L., Murphy, Dennis L., Grados, Marco A., Knowles, James A., Piacentini, John, Cullen, Bernadette, Bienvenu, Joseph O., 3rd, Rasmussen, Steven A., Geller, Daniel, Pauls, David L., Liang, Kung-Yee, Shugart, Yin Y., and Nestadt, Gerald

Published
2011
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91. SEPARATION ANXIETY DISORDER IN OCD†

Author

Mroczkowski, Megan M., Goes, Fernando S., Riddle, Mark A., Grados, Marco A., Joseph Bienvenu, O., 3rd, Greenberg, Benjamin D., Fyer, Abby J., McCracken, James T., Rauch, Scott L., Murphy, Dennis L., Knowles, James A., Piacentini, John, Cullen, Bernadette, Rasmussen, Steven A., Geller, Daniel A., Pauls, David L., Liang, Kung-Yee, Nestadt, Gerald, and Samuels, Jack F.

Published
2011
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93. Structural and functional MRI of altered brain development in a novel adolescent rat model of quinpirole-induced compulsive checking behavior

Author

Straathof, Milou, primary, Blezer, Erwin L.A., additional, van Heijningen, Caroline, additional, Smeele, Christel E., additional, van der Toorn, Annette, additional, Buitelaar, Jan K., additional, Glennon, Jeffrey C., additional, Otte, Willem M., additional, Dijkhuizen, Rick M., additional, Buitelaar, Jan, additional, de Ruiter, Saskia, additional, Naaijen, Jilly, additional, Akkermans, Sophie, additional, Mennes, Maarten, additional, Zwiers, Marcel, additional, Ilbegi, Shahrzad, additional, Hennissen, Leonie, additional, Glennon, Jeffrey, additional, van de Vondervoort, Ilse, additional, Kapusta, Katarzyna, additional, Bielczyk, NaAAtalia, additional, Amiri, Houshang, additional, Havenith, Martha, additional, Franke, Barbara, additional, Poelmans, Geert, additional, Bralten, Janita, additional, Heskes, Tom, additional, Sokolova, Elena, additional, Groot, Perry, additional, Williams, Steven, additional, Murphy, DeAAclan, additional, Lythgoe, David, additional, Bruchhage, Muriel, additional, Dud, Iulia, additional, Voinescu, Bogdan, additional, Dittmann, Ralf, additional, Banaschewski, Tobias, additional, Brandeis, Daniel, additional, Mechler, Konstantin, additional, Berg, Ruth, additional, Wolf, Isabella, additional, Häge, Alexander, additional, Landauer, Michael, additional, Hohmann, Sarah, additional, Schlier, Regina Boecker, additional, Ruff, Matthias, additional, Mandl, René, additional, Dijkhuizen, Rick, additional, Blezer, Erwin, additional, Straathof, Milou, additional, van der Marel, Kajo, additional, Pullens, Pim, additional, Mol, Wouter, additional, Otte, Willem, additional, Durston, Sarah, additional, Mensen, VinAAcent, additional, Oranje, Bob, additional, Joel, Daphna, additional, Cryan, John, additional, Petryshen, Tracey, additional, Pauls, David, additional, Saito, Mai, additional, Heckman, Angelique, additional, Bahn, Sabine, additional, Schwalber, Ameli, additional, and Florea, Ioana, additional

Published
2020
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95. Social and emotional adjustment in children affected with Gilles de la Tourette's Syndrome: Associations with ADHD and family functioning

Author

Carter, Alice S., O'Donnell, Deborah A., Schultz, Robert T., Scahill, Lawrence, Leckman, James F., and Pauls, David L.

Subjects
Attention-deficit hyperactivity disorder -- Social aspects, Child psychology -- Research, Tourette's syndrome -- Social aspects, Psychology and mental health
Abstract

The social-emotional functioning among children with Gilles de la Tourette's syndrome (TS) alone and those with TS and Attention Deficit Hyperactivity Disorder (ADHD) were compared. The contribution of family emotion expression and conflict to the social competence of such children was also examined. Children with TS seemed to be at risk for problems in the internalizing domain, but those with TS and ADHD were at increased risk for externalizing problems.

Published
2000

96. A genome-wide linkage and association scan reveals novel loci for autism

Author

Weiss, Lauren A., Arking, Dan E., Daly, Mark J., Chakravarti, Aravinda, Brune, Camille W., West, Kristen, O’Connor, Ashley, Hilton, Gina, Tomlinson, Rebecca L., West, Andrew B., Cook, Edwin H., Jr, Green, Todd, Chang, Shun-Chiao, Gabriel, Stacey, Gates, Casey, Hanson, Ellen M., Kirby, Andrew, Korn, Joshua, Kuruvilla, Finny, McCarroll, Steven, Morrow, Eric M., Neale, Benjamin, Purcell, Shaun, Sasanfar, Roksana, Sougnez, Carrie, Stevens, Christine, Altshuler, David, Gusella, James, Santangelo, Susan L., Sklar, Pamela, Tanzi, Rudolph, Anney, Richard, Bailey, Anthony J., Baird, Gillian, Battaglia, Agatino, Berney, Tom, Betancur, Catalina, Bölte, Sven, Bolton, Patrick F., Brian, Jessica, Bryson, Susan E., Buxbaum, Joseph D., Cabrito, Ines, Cai, Guiqing, Cantor, Rita M., Coon, Hilary, Conroy, Judith, Correia, Catarina, Corsello, Christina, Crawford, Emily L., Cuccaro, Michael L., Dawson, Geraldine, de Jonge, Maretha, Devlin, Bernie, Duketis, Eftichia, Ennis, Sean, Estes, Annette, Farrar, Penny, Fombonne, Eric, Freitag, Christine M., Gallagher, Louise, Geschwind, Daniel H., Gilbert, John, Gill, Michael, Gillberg, Christopher, Goldberg, Jeremy, Green, Andrew, Green, Jonathan, Guter, Stephen J., Haines, Jonathan L., Hallmayer, Joachim F., Hus, Vanessa, Klauck, Sabine M., Korvatska, Olena, Lamb, Janine A., Laskawiec, Magdalena, Leboyer, Marion, Le Couteur, Ann, Leventhal, Bennett L., Liu, Xiao-Qing, Lord, Catherine, Lotspeich, Linda J., Maestrini, Elena, Magalhaes, Tiago, Mahoney, William, Mantoulan, Carine, McConachie, Helen, McDougle, Christopher J., McMahon, William M., Marshall, Christian R., Miller, Judith, Minshew, Nancy J., Monaco, Anthony P., Munson, Jeff, Nurnberger, John I., Jr, Oliveira, Guiomar, Pagnamenta, Alistair, Papanikolaou, Katerina, Parr, Jeremy R., Paterson, Andrew D., Pericak-Vance, Margaret A., Pickles, Andrew, Pinto, Dalila, Piven, Joseph, Posey, David J., Poustka, Annemarie, Poustka, Fritz, Regan, Regina, Reichert, Jennifer, Renshaw, Katy, Roberts, Wendy, Roge, Bernadette, Rutter, Michael L., Salt, Jeff, Schellenberg, Gerard D., Scherer, Stephen W., Sheffield, Val, Sutcliffe, James S., Szatmari, Peter, Tansey, Katherine, Thompson, Ann P., Tsiantis, John, Van Engeland, Herman, Vicente, Astrid M., Vieland, Veronica J., Volkmar, Fred, Wallace, Simon, Wassink, Thomas H., Wijsman, Ellen M., Wing, Kirsty, Wittemeyer, Kerstin, Yaspan, Brian L., Zwaigenbaum, Lonnie, Yoo, Seung-Yun, Sean Hill, Robert, Mukaddes, Nahit M., Balkhy, Soher, Gascon, Generoso, Al-Saad, Samira, Hashmi, Asif, Ware, Janice, Joseph, Robert M., LeClair, Elaine, Partlow, Jennifer N., Barry, Brenda, Walsh, Christopher A., Pauls, David, Moilanen, Irma, Ebeling, Hanna, Mattila, Marja-Leena, Kuusikko, Sanna, Jussila, Katja, Ignatius, Jaakko, Tolouei, Ala, Ghadami, Majid, Rostami, Maryam, Hosseinipour, Azam, Valujerdi, Maryam, Andresen, Kara, Winkloski, Brian, Haddad, Stephen, Kunkel, Lou, Kohane, Zak, Tran, Tram, Won Kong, Sek, O’Neil, Stephanie Brewster, Hundley, Rachel, Holm, Ingrid, Peters, Heather, Baroni, Elizabeth, Cangialose, Aislyn, Jackson, Lindsay, Albers, Lisa, Becker, Ronald, Bridgemohan, Carolyn, Friedman, Sandra, Munir, Kerim, Nazir, Ramzi, Palfrey, Judith, Schonwald, Alison, Simmons, Esau, Rappaport, Leonard A., Gauthier, Julie, Mottron, Laurent, Joober, Ridha, Rouleau, Guy, Rehnstrom, Karola, von Wendt, Lennart, and Peltonen, Leena

Published
2009
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99. Evidence for potential relationship between SLC1A1 and a putative genetic linkage region on chromosome 14q to obsessive-compulsive disorder with compulsive hoarding

Author

Liang, Kung-Yee, Wang, Ying, Shugart, Yin Yao, Grados, Marco, Fyer, Abby J., Rauch, Scott, Murphy, Dennis, McCracken, James, Rasmussen, Steven, Cullen, Bernadette, Hoehn-Saric, Rudolf, Greenberg, Benjamin, Pinto, Anthony, Knowles, James, Piacentini, John, Pauls, David, Bienvenu, O., Riddle, Mark, Samuels, Jack, and Nestadt, Gerald

Published
2008
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