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L-histidine decarboxylase and Tourette's syndrome
- Source :
- The New England Journal of Medicine. May 20, 2010, Vol. 362 Issue 20, p1901, 8 p.
- Publication Year :
- 2010
-
Abstract
- An analysis of linkage in a two-generation pedigree leading to the identification of a rare functional mutation in the HDC gene encoding L-histidine decarboxylase and Tourette's syndrome, the rate-limiting enzyme in histamine biosynthesis is described. The study findings along with the published data from model system provide insight into the role for histaminergic neurotransmission in the mechanism and modulation of Tourette's syndrome and tics.
Details
- Language :
- English
- ISSN :
- 00284793
- Volume :
- 362
- Issue :
- 20
- Database :
- Gale General OneFile
- Journal :
- The New England Journal of Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.229750277