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1,034 results on '"Miele, Luca"'

51. The Liver in Heart Failure: From Biomarkers to Clinical Risk

Author: Aspromonte, Nadia, primary, Fumarulo, Isabella, additional, Petrucci, Lucrezia, additional, Biferali, Bianca, additional, Liguori, Antonio, additional, Gasbarrini, Antonio, additional, Massetti, Massimo, additional, and Miele, Luca, additional
Published: 2023
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52. Accuracy, Reliability, and Comprehensibility of ChatGPT-Generated Medical Responses for Patients With Nonalcoholic Fatty Liver Disease

Author: Pugliese, Nicola, primary, Wai-Sun Wong, Vincent, additional, Schattenberg, Jörn M., additional, Romero-Gomez, Manuel, additional, Sebastiani, Giada, additional, Aghemo, Alessio, additional, Castera, Laurent, additional, Hassan, Cesare, additional, Manousou, Pinelopi, additional, Miele, Luca, additional, Peck, Raquel, additional, Petta, Salvatore, additional, Valenti, Luca, additional, and Younossi, Zobair M., additional
Published: 2023
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53. Pretreatment prediction of response to ursodeoxycholic acid in primary biliary cholangitis: development and validation of the UDCA Response Score

Author: Thomas, Caradog, Rahman, Meshbah, Yapp, Tom, Lye Ch'ng, Chin, Harrison, Melanie, Sturgess, Richard, Galaska, Roman, Healey, Chris, Whiteman, Jessica, Czaijkowski, Marek, Gray, Catherine, Gunasekera, Anton, Gyawli, Pranab, Premchand, Purushothaman, Mann, Steven, Elliott, Keith, Kapur, Kapil, Watson, Alan, Foster, Graham, Trembling, Paul, Subhani, Javaid, Harvey, Rory, McCorry, Roger, Adgey, Carolyn, Hobson, Lucie, Mulvaney-Jones, Caroline, Evans, Richard, Mathialahan, Thiriloganathan, Ramanaden, David, Gasem, Jaber, Van Duyvenvoorde, Greta, Shorrock, Christopher, Seward, Katie, Southern, Paul, Tibble, Jeremy, Penn, Ruth, Gorard, David, Maiden, Jane, Damant, Rose, Palegwala, Altaf, Jones, Susan, Alexander, Graeme, Mells, George, Sandford, Richard, Dolwani, Sunil, Prince, Martin, Silvestre, Valeria, Foxton, Matthew, Dungca, Eleanor, Mitchison, Harriet, Wheatley, Natalie, Gooding, Ian, Doyle, Helen, Karmo, Mazn, Kent, Melanie, Saksena, Sushma, Braim, Delyth, Patel, Minesh, Lord, Susan, Ede, Roland, Paton, Alison, Austin, Andrew, Lancaster, Nicola, Sayer, Joanna, Gibbins, Andrew, Hogben, Karen, Hovell, Chris, Fisher, Neil, Carter, Martyn, Koss, Konrad, Musselwhite, Janine, Muscariu, Florin, Piotreowicz, Andrzej, McKay, Alexandra, Grimley, Charles, Neal, David, Ting Tan, Lai, Lim, Guan, Brighton, Jacqueline, Foale, Carole, Ala, Aftab, Saeed, Athar, Flahive, Kerry, Wood, Gordon, Townshend, Paula, Ford, Chris, Brown, Jonathan, Kordula, Jean, Bowles, Jane, Wilkinson, Mark, Palmer, Caroline, Ramage, John, Gordon, Harriet, Featherstone, James, Ridpath, Jo, Ngatchu, Theodore, Levi, Sass, Shaukat, Syed, Sadeghian, Joy, Shidrawi, Ray, Williams, Bronwen, Abouda, George, Jones, Sarah, Duggan, Claire, Hynes, Abigail, Narain, Mark, Rees, Ian, Salam, Imroz, Crossey, Mary, Taylor-Robinson, Simon, Brown, Ashley, MacNicol, Carolyn, Williams, Simon, Wilhelmsen, Elva, Banim, Paul, Raymode, Parizade, Chilton, Andrew, Das, Debasish, Lee, Hye-Jeong, Curtis, Howard, Heneghan, Michael, Gess, Markus, Durant, Emma, Drake, IM, Bishop, Rebecca, Davies, Mervyn, Jones, Rebecca, Aldersley, Mark, Ncube, Noma, McNair, Alistair, Srirajaskanthan, Raj, Sen, Sambit, Casey, Rebecca, Bird, George, Mendall, Mike, Cowley, Caroline, Barnardo, Adrian, Kitchen, Paul, Yoong, Kevin, Amore, Kelly, Sirdefield, Dawn, Orpe, Jacky, Mathew, Ray, MacFaul, George, Wrigth, Aruna, Shah, Amir, Evans, Chris, Keggans, Janie, Bird, Bridget, Baxter, Gwen, Saha, Subrata, Pollock, Katharine, Hughes, Maggie, Bramley, Peter, Grieve, Emma, Young, Karin, Fraser, Andrew, Mukhopadhya, Ashis, Ocker, Kate, Mills, Peter, Hines, Francis, Shallcross, Chris, Wilkins, Joy, Grellier, Leonie, Campbell, Stewart, Martin, Kirsty, Bathgate, Andrew, Innes, Caron, Shepherd, Alan, Rushbrook, Simon, Valliani, Talal, Przemioslo, Robert, Fairlamb, Helen, Macdonald, Chris, Eastick, Anne, Metcalf, Jane, Tanqueray, Elizabeth, Shmueli, Udi, Holbrook, Becky, Davis, Andrew, Browning, Julie, Naqvi, Asifabbas, Walker, Kirsten, Lee, Tom, Verheyden, Juliette, Slininger, Susan, Ryder, Stephen D, Chapman, Roger, Collier, Jane, O'Donnell, Denise, Stafford, Lizzie, Williamson, Kate, Kent, Linda, Klass, Howard, Ninkovic, Mary, March, Linda, Cramp, Matthew, Simpson, Diane, Dickson, Christine, Sharer, Nicholas, Hayes, Maria, Goggin, Patrick, Quinne, Mary, Pearson, Sallyanne, Hoeroldt, Barbara, Jones, Linda, Wright, Alice, Booth, Jonathan, Loftus, Alison, Lipscomb, George, Dewhurst, Hannah, Gunter, Emma, Williams, Earl, Fouracres, Anna, Farrington, Liz, Graves, Lyn, Hussaini, Hyder, Stableforth, Bill, Marriott, Suzie, Ayres, Reuben, Leoni, Marina, Burroughs, Andrew, Marshall, Eileen, Thorburn, Douglas, Tyrer, David, Martin, Kate, Lombard, Martin, Patanwala, Imran, Dali-Kemmery, Lola, Lambourne, Victoria, Maltby, Julia, Vyas, Samir, Colley, Julie, Shinder, Bal, Singhal, Saket, Jones, Jayne, Mills, Marisa, Gleeson, Dermot, Carnahan, Mandy, Butterworth, Jeff, Boulton, Kerenza, Taylor, Natalie, George, Keith, Harding, Tim, Tregonning, Julie, Douglass, Andrew, Brown, Carly, Clifford, Gayle, Panter, Simon, Gocher, Denise, Shearman, Jeremy, Bray, Gary, Hamilton, Maria, Butcher, Graham, Forton, Daniel, Mclindon, John, Curtis, Janette, Das, Debashis, Shewan, Tracey, Cowan, Matthew, Whatley, Gregory, Nasseri, Mariam, Grover, Bob, Sivaramakrishnan, Nurani, Ducker, Samantha, Houghton, Kathryn, Jones, David, Griffiths, Laura, Tripoli, Sherill, Pitcher, Maxton, Shpuza, Ervin, White, Nikki, Ghosh, Deb, Douds, Andrew, Green, Marie, Brookes, Matthew, Cumlat, Lourdes, Wong, Voi Shim, Warner, Karen, Netherton, Kimberley, Mandal, Adtya, Jain, Snjiv, Gupta, Hemant, Sanghi, Pradeep, Pereira, Steve, Neuberger, James, Gunson, Bridget, Hirschfield, Gideon, Lim, Reina Teegan, Gallagher, Susan, Clement, Darren, Brind, Alison, Watts, Gill, Mupudzi, Mcdonald, Wright, Mark, Gitahi, Jane, Gordon, Fiona, Gocher, Denis, Unitt, Esther, Pateman, Hilary, Batham, Sally, Delahooke, Toby, Grant, Allister, Conder, Jill, Higham, Andrew, Cox, Mark, O'Donohoe, Lynn, Currie, Lynn, King, Alistair, Oblak, Metod, Collins, Carole, Whalley, Simon, Quinn, Marie, Baird, Yolanda, Amey, Isobel, Fraser, Jocelyn, Li, Andy, Cotterill, Donna, Bell, Andrew, Singhal, Amit, Gee, Ian, Greer, Sandra, Ang, Yeng, Ransford, Rupert, Allison, Joanna, Gotto, James, Dyer, Simon, Sweeting, Helen, Millson, Charles, Invernizzi, Pietro, Carbone, Marco, Cristoferi, Laura, Bonato, Giulia, Malinverno, Federica, Bernuzzi, Francesca, Alvaro, Domenico, Labbadia, Giancarlo, Bragazzi, Maria Consiglia, Andreone, Pietro, Muratori, Luigi, Azzaroli, Francesco, Floreani, Annarosa, Galli, Andrea, Tarocchi, Mirko, Giannini, Edoardo, Miele, Luca, Gasbarrini, Antonio, Grieco, Antonio, Marrone, Giuseppe, Donato, Maria Francesca, Valenti, Luca, Marra, Fabio, Marzioni, Marco, Maroni, Luca, Rigamonti, Cristina, Zuin, Massimo, Battezzati, Pier Maria, Picciotto, Antonino, Nardi, Alessandra, Flack, Steve, Carpino, Guido, Varvaropoulou, Nikoletta, Gavrila, Caius, Spicer, Ann, Badrock, Jonathan, Cardinale, Vincenzo, Ainsworth, Holly F, Heneghan, Michael A, Neuberger, James M, Donato, Maria F, Kirby, John, Mitchell-Thain, Robert, Sampaziotis, Fotios, Gaudio, Eugenio, Ronca, Vincenzo, Gerussi, Alessio, Stocken, Deborah D, Cordell, Heather J, Hirschfield, Gideon M, Alexander, Graeme J, Sandford, Richard N, Jones, David E, and Mells, George F
Published: 2018
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54. Different biochemical patterns in type II and type III mixed cryoglobulinemia in HCV positive patients

Author: Basile, Umberto, Gulli, Francesca, Gragnani, Laura, Pocino, Krizia, Napodano, Cecilia, Miele, Luca, Santini, Stefano Angelo, Marino, Mariapaola, Zignego, Anna Linda, and Rapaccini, Gian Ludovico
Published: 2018
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55. NAFLD in children: new genes, new diagnostic modalities and new drugs

Author: Nobili, Valerio, Alisi, Anna, Valenti, Luca, Miele, Luca, Feldstein, Ariel E., and Alkhouri, Naim
Published: 2019
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56. Accuracy of 100 Hz transient elastography-based spleen stiffness for the identification of advanced fibrosis in biopsy-proven non-alcoholic fatty liver disease

Author: Armandi, Angelo, primary, Liguori, Antonio, additional, Merizian, Talal, additional, Werner, Merle Marie, additional, Michel, Maurice, additional, Labenz, Christian, additional, Romero, Carmen Lara, additional, Del Barrio Azaceta, María, additional, Pino, Belen, additional, Straub, Beate, additional, Gomez, Manuel Romero, additional, Miele, Luca, additional, and Schattenberg, Jörn, additional
Published: 2023
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57. A prospective multicenter study to examine the impact of acquired and genetic predictors on Hepatocellular carcinoma risk in patients with advanced NAFLD: first report

Author: Pelusi, Serena, primary, Bianco, Cristiana, additional, Ronzoni, Luisa, additional, Cherubini, Alessandro, additional, Marini, Ilaria, additional, Malvestiti, Francesco, additional, D’Ambrosio, Roberta, additional, Fracanzani, Anna Ludovica, additional, Cespiati, Annalisa, additional, Soardo, Giorgio, additional, Pivetta, Stephanie, additional, Miele, Luca, additional, Liguori, Antonio, additional, Bugianesi, Elisabetta, additional, Rosso, Chiara, additional, Petta, Salvatore, additional, Pennisi, Grazia, additional, Gentilucci, Umberto Vespasiani, additional, Tavaglione, Federica, additional, Federico, Alessandro, additional, Russo, Francesco Paolo, additional, Zanaga, Paola, additional, Masarone, Mario, additional, Prati, Daniele, additional, and Valenti, Luca, additional
Published: 2023
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58. Free light chains: novel serum biomarkers for NASH stratification, an update

Author: Liguori, Antonio, primary, Basile, Umberto, additional, D’Ambrosio, Francesca, additional, Napodano, Cecilia, additional, Tomasello, Lidia, additional, Mancuso, Fabrizio, additional, Marrone, Giuseppe, additional, Biolato, Marco, additional, Rapaccini, Gianludovico, additional, Gasbarrini, Antonio, additional, Grieco, Antonio, additional, and Miele, Luca, additional
Published: 2023
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59. Validation of elastography criteria and cACLD risk model for diagnosis of compensated advanced chronic liver disease (cACLD) in NAFLD patients

Author: Liguori, Antonio, primary, Zoncapè, Mirko, additional, Patel, Roshni, additional, Roccarina, Davide, additional, Viceconti, Nicholas, additional, Petrucci, Lucrezia, additional, Prat, Laura Iogna, additional, D’Ambrosio, Francesca, additional, Marrone, Giuseppe, additional, Biolato, Marco, additional, Mantovani, Anna, additional, Clancy, Jennifer-Louise, additional, Goyale, Atul, additional, Gasbarrini, Antonio, additional, Grieco, Antonio, additional, Miele, Luca, additional, and Tsochatzis, Emmanuel, additional
Published: 2023
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60. Urinary lithogenic profile of patients with non-alcoholic fatty liver disease

Author: Bargagli, Matteo, primary, Liguori, Antonio, additional, Napodano, Cecilia, additional, Baroni, Silvia, additional, Tomasello, Lidia, additional, Pizzolante, Fabrizio, additional, De Matthaeis, Nicoletta, additional, De Ninno, Grazia, additional, Grieco, Antonio, additional, Gasbarrini, Antonio, additional, Gambaro, Giovanni, additional, Ferraro, Pietro Manuel, additional, and Miele, Luca, additional
Published: 2023
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61. Branched chain amino acids in hepatic encephalopathy and sarcopenia in liver cirrhosis: Evidence and uncertainties

Author: Marrone, Giuseppe, primary, Serra, Amato, additional, Miele, Luca, additional, Biolato, Marco, additional, Liguori, Antonio, additional, Grieco, Antonio, additional, and Gasbarrini, Antonio, additional
Published: 2023
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62. Impact of PNPLA3 rs738409 polymorphism on the development of liver-related events in patients with non-alcoholic fatty liver disease

Author: Rosso, Chiara, primary, Caviglia, Gian Paolo, additional, Birolo, Giovanni, additional, Armandi, Angelo, additional, Pennisi, Grazia, additional, Pelusi, Serena, additional, Younes, Ramy, additional, Liguori, Antonio, additional, Perez-Diaz-del-Campo, Nuria, additional, Nicolosi, Aurora, additional, Govaere, Olivier, additional, Castelnuovo, Gabriele, additional, Olivero, Antonella, additional, Abate, Maria Lorena, additional, Ribaldone, Davide Giuseppe, additional, Fariselli, Piero, additional, Valenti, Luca, additional, Miele, Luca, additional, Petta, Salvatore, additional, Romero-Gomez, Manuel, additional, Anstee, Quentin M., additional, and Bugianesi, Elisabetta, additional
Published: 2023
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63. Ombitasvir, paritaprevir, and ritonavir, with or without dasabuvir, plus ribavirin for patients with hepatitis C virus genotype 1 or 4 infection with cirrhosis (ABACUS): a prospective observational study

Author: Tabone, Marco, Andreoni, Massimo, Teti, Elisabetta, Angelico, Mario, Persico, Marcello, Masarone, Mario, Chiodera, Aledssandro, Solinas, Attilio, delle Monache, Marco, Cecere, Roberto, Maria Schimizzi, Anna, Piovesan, Sara, Campagnolo, Davide, Chiara Piras, Maria, Zolfino, Teresa, Paolo Russo, Francesca, Morelli, Olivia, Sangiovanni, Vincenzo, Onofrio, Mirella, Iodice, Valentina, Izzi, Antonio, Pirisi, Massimo, Danieli, Elena, Vinci, Maria, Rizzardini, Giuliano, Fagiuoli, Stefano, Pasulo, Luisa, D'Arminio Monforte, Antonella, Zuin, Massimo, Giorgini, Alessia, Simeone, Filomena, Piali, Guido, Lo Guercio, Carmela, Federico, Alessandro, Brancaccio, Giuseppina, Marrone, Aldo, Abbati, Giuseppe, Boarini, Chiara, Borghi, Vanni, Bernabucci, Veronica, Corti, Giampaolo, Monti, Monica, Rizzetto, Mario, Martini, Silvia, Andreone, Pietro, Gianstefani, Alice, Lenzi, Marco, Verucchi, Gabriella, Toniutto, Pierluigi, Borgia, Guglielmo, Caporaso, Nicola, Morisco, Filomena, Nardone, Gaetano, Angrisani, Debora, Giacometti, Andrea, Benedetti, Antonio, Tarantino, Giuseppe, Marsetti, Fabio, Tavio, Marcello, Novara, Sergio, Antonia Santantonio, Teresa, Serviddio, Gaetano, Brunetto, Maurizia, Coco, Barbara, Angarano, Gioacchino, Milella, Michele, Barone, Michele, Di Leo, Alfredo, Ettore Sansonno, Domenico, Cacciola, Irene, Boffa, Nicola, Saracco, Giorgio, Di Biagio, Antonio, Picciotto, Antonino, de Luca, Andrea, Calvaruso, Vincenza, Corradori, Silvia, Ferrari, Carlo, Orlandini, Alessandra, Maida, Ivana, Torti, Carlo, Chessa, Luchino, Felder, Martina, Vespasiani Gentilucci, Umberto, Angeli, Paolo, Romano, Antonietta, Ludovico Rapaccini, Gian, Miele, Luca, Cima, Serena, Luisa Russo, Maria, Cozzolongo, Raffaele, Onnelli, Giovanna, D'Offizi, Giampiero, Lionetti, Raffaella, Montalbano, Marzia, Guerra, Michele, Di Perri, Giovanni, Boglione, Lucio, Capra, Franco, Carolo, Giada, Ieluzzi, Donatella, Antonini, Cinzia, Termite, Antonio, Madonia, Salvatore, Tarquini, Pierluigi, Parruti, Giustino, Vecchiet, Giacomo, Falasca, Katia, Menzaghi, Barbara, Quirino, Tiziana, Dentone, Chiara, Maria Piscaglia, Anna, Rossi, Cristina, Giordani, Maria, Fontanella, Luca, Cassola, Giovanni, Russello, Maurizio, Cristaudo, Antonio, Giacomet, Vania, Colombo, Massimo, Donato, Francesca, Durante, Emanuele, Cosco, Lucio, Marignani, Massimo, Quartini, Mariano, Memoli, Massimo, Ganga, Roberto, Ponti, Laura, Soria, Alessandro, Grazia Rumi, Maria, Gulminetti, Roberto, Maserati, Renato, Mondelli, Mario, Lazzarin, Adriano, Rita Parisi, Maria, Canovari, Benedetta, Avancini, Ivo, Pravadelli, Cecilia, Blanc, Pier, Pasquazzi, Caterina, Maria Mastroianni, Claudio, Lichtner, Myriam, Distefano, Marco, Magnani, Silvia, Paganin, Simona, Erne, Elke, Gatti, Pietro, Tundi, Paolo, Calabrese, Paolo, Gasbarrini, Antonio, Grieco, Antonio, Coppola, Nicola, Del Poggio, Paolo, Levrero, Massimo, Talliani, Gloria, Vullo, Vincenzo, Cauda, Roberto, La Monica, Silvia, Potenza, Domenico, Rizzo, Salvatore, Castelli, Francesco, Marie Pigozzi, Grazielle, Ciancio, Alessia, Romagnoli, Dante, Barchetti, Federica, Ivanovic, Jelena, Longo, Olimpia, Petraglia, Sandra, Paola Trotta, Maria, Petta, Salvatore, Marzioni, Marco, Russo, Pierluigi, Aghemo, Alessio, Alberti, Alfredo, Ascione, Antonio, Antinori, Andrea, Bruno, Raffaele, Bruno, Savino, Chirianni, Antonio, Gaeta, Giovanni Battista, Giannini, Edoardo G, Merli, Manuela, Messina, Vincenzo, Montilla, Simona, Perno, Carlo Federico, Puoti, Massimo, Raimondo, Giovanni, Rendina, Maria, Silberstein, Francesca Ceccherini, Villa, Erica, Zignego, Anna Linda, Pani, Luca, and Craxì, Antonio
Published: 2017
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64. AISF position paper on nonalcoholic fatty liver disease (NAFLD): Updates and future directions

Author: Lonardo, Amedeo, Nascimbeni, Fabio, Targher, Giovanni, Bernardi, Mauro, Bonino, Ferruccio, Bugianesi, Elisabetta, Casini, Alessandro, Gastaldelli, Amalia, Marchesini, Giulio, Marra, Fabio, Miele, Luca, Morisco, Filomena, Petta, Salvatore, Piscaglia, Fabio, Svegliati-Baroni, Gianluca, Valenti, Luca, and Bellentani, Stefano
Published: 2017
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65. Circulating histone signature of human lean metabolic-associated fatty liver disease (MAFLD)

Author: Buzova, Diana, Maugeri, Andrea, Liguori, Antonio, Napodano, Cecilia, Lo Re, Oriana, Oben, Jude, Alisi, Anna, Gasbarrini, Antonio, Grieco, Antonio, Cerveny, Jan, Miele, Luca, and Vinciguerra, Manlio
Published: 2020
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66. Rare ATG7 genetic variants predispose patients to severe fatty liver disease

Author: Baselli, Guido A, Jamialahmadi, Ovei, Pelusi, Serena, Ciociola, Ester, Malvestiti, Francesco, Saracino, Marco, Santoro, Luigi, Cherubini, Alessandro, Dongiovanni, Paola, Maggioni, Marco, Bianco, Cristiana, Tavaglione, Federica, Cespiati, Annalisa, Mancina, Rosellina M, D'Ambrosio, Roberta, Vaira, Valentina, Petta, Salvatore, Miele, Luca, Vespasiani-Gentilucci, Umberto, Federico, Alessandro, Pihlajamaki, Jussi, Bugianesi, Elisabetta, Fracanzani, Anna L, Reeves, Helen L, Soardo, Giorgio, Prati, Daniele, Romeo, Stefano, Valenti, Luca Vc, Miele, Luca (ORCID:0000-0003-3464-0068), Baselli, Guido A, Jamialahmadi, Ovei, Pelusi, Serena, Ciociola, Ester, Malvestiti, Francesco, Saracino, Marco, Santoro, Luigi, Cherubini, Alessandro, Dongiovanni, Paola, Maggioni, Marco, Bianco, Cristiana, Tavaglione, Federica, Cespiati, Annalisa, Mancina, Rosellina M, D'Ambrosio, Roberta, Vaira, Valentina, Petta, Salvatore, Miele, Luca, Vespasiani-Gentilucci, Umberto, Federico, Alessandro, Pihlajamaki, Jussi, Bugianesi, Elisabetta, Fracanzani, Anna L, Reeves, Helen L, Soardo, Giorgio, Prati, Daniele, Romeo, Stefano, Valenti, Luca Vc, and Miele, Luca (ORCID:0000-0003-3464-0068)
Abstract: Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver disorders and has a strong heritable component. The aim of this study was to identify new loci that contribute to severe NAFLD by examining rare variants.Methods: We performed whole-exome sequencing in in-dividuals with NAFLD and advanced fibrosis or hepatocellular carcinoma (n = 301) and examined the enrichment of likely pathogenic rare variants vs. the general population. This was followed by validation at the gene level.Results: In patients with severe NAFLD, we observed an enrichment of the p.P426L variant (rs143545741 C>T; odds ratio [OR] 5.26, 95% CI 2.1-12.6; p = 0.003) of autophagy-related 7 (ATG7), which we characterized as a loss-of-function, vs. the general population, and an enrichment in rare variants affecting the catalytic domain (OR 13.9; 95% CI 1.9-612; p = 0.002). In the UK Biobank cohort, loss-of-function ATG7 variants increased the risk of cirrhosis and hepatocellular carcinoma (OR 3.30; 95% CI 1.1-7.5 and OR 12.30, 95% CI 2.6-36, respectively; p <0.001 for both). The low-frequency loss-of-function p.V471A variant (rs36117895 T>C) was also associated with severe NAFLD in the clinical cohort (OR 1.7; 95% CI 1.2-2.5; p = 0.003), predisposed to hepatocellular ballooning (p = 0.007) evolving to fibrosis in the Liver biopsy cohort (n = 2,268), and was associated with liver injury in the UK Biobank (aspartate aminotransferase levels, p <0.001), with a larger effect in severely obese in-dividuals in whom it was linked to hepatocellular carcinoma (p = 0.009). ATG7 protein localized to periportal hepatocytes, particularly in the presence of ballooning. In the Liver Tran-scriptomic cohort (n = 125), ATG7 expression correlated with suppression of the TNFa pathway, which was conversely upregulated in p.V471A carriers.Conclusions: We identified rare and low-frequency ATG7 loss-of -function variants that promote NAFLD progression by impairing autophagy an
Published: 2022

67. Two elective invasive procedures after a single avatrombopag treatment in a patient with liver cirrhosis and severe thrombocytopenia

Author: Biolato, Marco, Vitale, Federica, Marrone, Giuseppe, Miele, Luca, Grieco, Antonio, Miele, Luca (ORCID:0000-0003-3464-0068), Grieco, Antonio (ORCID:0000-0002-0544-8993), Biolato, Marco, Vitale, Federica, Marrone, Giuseppe, Miele, Luca, Grieco, Antonio, Miele, Luca (ORCID:0000-0003-3464-0068), and Grieco, Antonio (ORCID:0000-0002-0544-8993)
Abstract: N/A
Published: 2022

68. Machine Learning-Assisted FTIR Analysis of Circulating Extracellular Vesicles for Cancer Liquid Biopsy

Author: Di Santo, Riccardo, Vaccaro, Maria, Romanò, Sabrina, Di Giacinto, Flavio, Papi, Massimiliano, Rapaccini, Gian Ludovico, De Spirito, Marco, Miele, Luca, Basile, Umberto, Ciasca, Gabriele, Di Giacinto, Flavio (ORCID:0000-0002-6726-7768), Papi, Massimiliano (ORCID:0000-0002-0029-1309), Rapaccini, Gian Ludovico (ORCID:0000-0002-6467-857X), De Spirito, Marco (ORCID:0000-0003-4260-5107), Miele, Luca (ORCID:0000-0003-3464-0068), Ciasca, Gabriele (ORCID:0000-0002-3694-8229), Di Santo, Riccardo, Vaccaro, Maria, Romanò, Sabrina, Di Giacinto, Flavio, Papi, Massimiliano, Rapaccini, Gian Ludovico, De Spirito, Marco, Miele, Luca, Basile, Umberto, Ciasca, Gabriele, Di Giacinto, Flavio (ORCID:0000-0002-6726-7768), Papi, Massimiliano (ORCID:0000-0002-0029-1309), Rapaccini, Gian Ludovico (ORCID:0000-0002-6467-857X), De Spirito, Marco (ORCID:0000-0003-4260-5107), Miele, Luca (ORCID:0000-0003-3464-0068), and Ciasca, Gabriele (ORCID:0000-0002-3694-8229)
Abstract: Extracellular vesicles (EVs) are abundantly released into the systemic circulation, where they show remarkable stability and harbor molecular constituents that provide biochemical information about their cells of origin. Due to this characteristic, EVs are attracting increasing attention as a source of circulating biomarkers for cancer liquid biopsy and personalized medicine. Despite this potential, none of the discovered biomarkers has entered the clinical practice so far, and novel approaches for the label-free characterization of EVs are highly demanded. In this regard, Fourier Transform Infrared Spectroscopy (FTIR) has great potential as it provides a quick, reproducible, and informative biomolecular fingerprint of EVs. In this pilot study, we investigated, for the first time in the literature, the capability of FTIR spectroscopy to distinguish between EVs extracted from sera of cancer patients and controls based on their mid-IR spectral response. For this purpose, EV-enriched suspensions were obtained from the serum of patients diagnosed with Hepatocellular Carcinoma (HCC) of nonviral origin and noncancer subjects. Our data point out the presence of statistically significant differences in the integrated intensities of major mid-IR absorption bands, including the carbohydrate and nucleic acids band, the protein amide I and II bands, and the lipid CH stretching band. Additionally, we used Principal Component Analysis combined with Linear Discriminant Analysis (PCA-LDA) for the automated classification of spectral data according to the shape of specific mid-IR spectral signatures. The diagnostic performances of the proposed spectral biomarkers, alone and combined, were evaluated using multivariate logistic regression followed by a Receiving Operator Curve analysis, obtaining large Areas Under the Curve (AUC = 0.91, 95% CI 0.81-1.0). Very interestingly, our analyses suggest that the discussed spectral biomarkers can outperform the classification ability of two wid
Published: 2022

69. Corrigendum to ‘Non-alcoholic fatty liver disease in adults 2021: A clinical practice guideline of the Italian Association for the Study of the Liver (AISF), the Italian Society of Diabetology (SID) and the Italian Society of Obesity (SIO)’ Nutrition, Metabolism and Cardiovascular diseases volume 32 issue 1 (2022) 1-16

Author: Marchesini, Giulio, primary, Bugianesi, Elisabetta, additional, Burra, Patrizia, additional, Marra, Fabio, additional, Miele, Luca, additional, Alisi, Anna, additional, Vajro, Piero, additional, Masarone, Mario, additional, Petta, Salvatore, additional, Persico, Marcello, additional, Svegliati-Baroni, Gianluca, additional, Valenti, Luca, additional, Federici, Massimo, additional, Purrello, Francesco, additional, Sasso, Ferdinando Carlo, additional, Targher, Giovanni, additional, Busetto, Luca, additional, Petroni, Maria Letizia, additional, Santini, Ferruccio, additional, Cammà, Calogero, additional, and Colli, Agostino, additional
Published: 2023
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70. Corrigendum to “Non-alcoholic fatty liver disease in adults 2021: A clinical practice guideline of the Italian Association for the Study of the Liver (AISF), the Italian Society of Diabetology (SID) and the Italian Society of Obesity (SIO)” [Dig Liver Dis 54 (2022) 170–182]

Author: Marchesini, Giulio, primary, Bugianesi, Elisabetta, additional, Burra, Patrizia, additional, Marra, Fabio, additional, Miele, Luca, additional, Alisi, Anna, additional, Vajro, Piero, additional, Masarone, Mario, additional, Petta, Salvatore, additional, Persico, Marcello, additional, Svegliati-Baroni, Gianluca, additional, Valenti, Luca, additional, Federici, Massimo, additional, Purrello, Francesco, additional, Sasso, Ferdinando Carlo, additional, Targher, Giovanni, additional, Busetto, Luca, additional, Petroni, Maria Letizia, additional, Santini, Ferruccio, additional, Cammà, Calogero, additional, and Colli, Agostino, additional
Published: 2023
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71. Letter to the Editor: Suboptimal performance of CAR-OLT score to predict 1-year risk of cardiovascular events after liver transplantation

Author: Biolato, Marco, Saracco, Margherita, Petti, Anna, Lavezzo, Bruna, Avolio, Alfonso Wolfango, Martini, Silvia, Grieco, Antonio, Renato, Romagnoli, Gasbarrini, Antonio, Agnes, Salvatore, Pompili, Maurizio, Miele, Luca, Marrone, Giuseppe, Liguori, Antonio, Pedicino, Daniela, Alessandra, Risso, Lidia, Tomasello, Francesco, Galati, Avolio, Alfonso Wolfango (ORCID:0000-0003-2491-7625), Antonio, Grieco (ORCID:0000-0002-0544-8993), Antonio, Gasbarrini (ORCID:0000-0002-7278-4823), Salvatore, Agnes (ORCID:0000-0002-3341-4221), Maurizio, Pompili (ORCID:0000-0001-6699-7980), Luca, Miele (ORCID:0000-0003-3464-0068), Giuseppe, Marrone, Antonio, Liguori, Daniela, Pedicino, Biolato, Marco, Saracco, Margherita, Petti, Anna, Lavezzo, Bruna, Avolio, Alfonso Wolfango, Martini, Silvia, Grieco, Antonio, Renato, Romagnoli, Gasbarrini, Antonio, Agnes, Salvatore, Pompili, Maurizio, Miele, Luca, Marrone, Giuseppe, Liguori, Antonio, Pedicino, Daniela, Alessandra, Risso, Lidia, Tomasello, Francesco, Galati, Avolio, Alfonso Wolfango (ORCID:0000-0003-2491-7625), Antonio, Grieco (ORCID:0000-0002-0544-8993), Antonio, Gasbarrini (ORCID:0000-0002-7278-4823), Salvatore, Agnes (ORCID:0000-0002-3341-4221), Maurizio, Pompili (ORCID:0000-0001-6699-7980), Luca, Miele (ORCID:0000-0003-3464-0068), Giuseppe, Marrone, Antonio, Liguori, and Daniela, Pedicino
Abstract: N/A
Published: 2023

72. Corrigendum to 'Non-alcoholic fatty liver disease in adults 2021: A clinical practice guideline of the Italian Association for the Study of the Liver (AISF), the Italian Society of Diabetology (SID) and the Italian Society of Obesity (SIO)' Nutrition, Metabolism and Cardiovascular diseases volume 32 issue 1 (2022) 1-16

Author: Marchesini, G., Bugianesi, E., Burra, P., Marra, F., Miele, Luca, Alisi, A., Vajro, P., Masarone, M., Petta, S., Persico, M., Svegliati-Baroni, G., Valenti, L., Federici, M., Purrello, F., Sasso, F. C., Targher, G., Busetto, L., Petroni, M. L., Santini, F., Camma, C., Colli, A., Miele L. (ORCID:0000-0003-3464-0068), Marchesini, G., Bugianesi, E., Burra, P., Marra, F., Miele, Luca, Alisi, A., Vajro, P., Masarone, M., Petta, S., Persico, M., Svegliati-Baroni, G., Valenti, L., Federici, M., Purrello, F., Sasso, F. C., Targher, G., Busetto, L., Petroni, M. L., Santini, F., Camma, C., Colli, A., and Miele L. (ORCID:0000-0003-3464-0068)
Abstract: N/A
Published: 2023

73. Machine learning algorithm improves the detection of NASH (NAS-based) and at-risk NASH: A development and validation study

Author: Jenny, Lee, Max, Westphal, Yasaman, Vali, Jerome, Boursier, Salvatorre, Petta, Rachel, Ostroff, Leigh, Alexander, Yu, Chen, Celine, Fournier, Andreas, Geier, Sven, Francque, Kristy, Wonder, Dina, Tiniako, Pierre, Bedossa, Mike, Allison, Georgios, Papatheodoridi, Helena, Cortez-Pinto, Raluca, Pai, Jean-Francois, Dufour, Diana Julie, Leeming, Stephen, Harrison, Jeremy, Cobbold, Adriaan G, Holleboom, Hannele, Yki-Järvinen, Javier, Crespo, Mattias, Ekstedt, Guruprasad P, Aithal, Elisabetta, Bugianesi, Manuel, Romero-Gomez, Richard, Torstenson, Morten, Karsdal, Carla, Yuni, Jörn M, Schattenberg, Detlef, Schuppan, Vlad, Ratziu, Clifford, Bra, Kevin, Duffin, Koos, Zwinderman, Michael, Pavlide, Quentin M, Anstee, Patrick M, Bossuyt, Anstee, Quentin M., Daly, Ann K., Govaere, Olivier, Cockell, Simon, Tiniakos, Dina, Bedossa, Pierre, Burt, Alastair, Oakley, Fiona, Cordell, Heather J., Day, Christopher P., Wonders, Kristy, Missier, Paolo, Mcteer, Matthew, Vale, Luke, Oluboyede, Yemi, Breckons, Matt, Bossuyt, Patrick M., Zafarmand, Hadi, Vali, Yasaman, Lee, Jenny, Nieuwdorp, Max, Holleboom, Adriaan G., Verheij, Joanne, Ratziu, Vlad, Clément, Karine, Patino-Navarrete, Rafael, Pais, Raluca, Paradis, Valerie, Schuppan, Detlef, Schattenberg, Jörn M., Surabattula, Rambabu, Myneni, Sudha, Straub, Beate K., Vidal-Puig, Toni, Vacca, Michele, Rodrigues-Cuenca, Sergio, Allison, Mike, Kamzolas, Ioanni, Petsalaki, Evangelia, Campbell, Mark, Lelliott, Chris J., Davies, Susan, Orešič, Matej, Hyötyläinen, Tuulia, Mcglinchey, Aiden, Mato, Jose M., Millet, Óscar, Dufour, Jean-Françoi, Berzigotti, Annalisa, Masoodi, Mojgan, Pavlides, Michael, Harrison, Stephen, Neubauer, Stefan, Cobbold, Jeremy, Mozes, Ferenc, Akhtar, Salma, Olodo-Atitebi, Seliat, Banerjee, Rajarshi, Kelly, Matt, Shumbayawonda, Elizabeth, Dennis, Andrea, Andersson, Anneli, Wigley, Ioan, Romero-Gómez, Manuel, Gómez-González, Emilio, Ampuero, Javier, Castell, Javier, Gallego-Durán, Rocío, Fernández, Isabel, Montero-Vallejo, Rocío, Karsdal, Morten, Guldager Kring Rasmussen, Daniel, Leeming, Diana Julie, Sinisi, Antonia, Musa, Kishwar, Sandt, Estelle, Tonini, Manuela, Bugianesi, Elisabetta, Rosso, Chiara, Armandi, Angelo, Marra, Fabio, Gastaldelli, Amalia, Svegliati, Gianluca, Boursier, Jérôme, Francque, Sven, Vonghia, Luisa, Driessen, Ann, Ekstedt, Mattia, Kechagias, Stergio, Yki-Järvinen, Hannele, Porthan, Kimmo, Arola, Johanna, van Mil, Saskia, Papatheodoridis, George, Cortez-Pinto, Helena, Rodrigues, Cecilia M. P., Valenti, Luca, Pelusi, Serena, Petta, Salvatore, Pennisi, Grazia, Miele, Luca, Geier, Andrea, Trautwein, Christian, Aithal, Guruprasad P., Francis, Susan, Hockings, Paul, Schneider, Moritz, Newsome, Philip, Hübscher, Stefan, Wenn, David, Rosenquist, Christian, Trylesinski, Aldo, Mayo, Rebeca, Alonso, Cristina, Duffin, Kevin, Perfield, James W., Chen, Yu, Yunis, Carla, Tuthill, Theresa, Harrington, Magdalena Alicia, Miller, Melissa, Chen, Yan, Mcleod, Euan Jame, Ross, Trenton, Bernardo, Barbara, Schölch, Corinna, Ertle, Judith, Younes, Ramy, Oldenburger, Anouk, Ostroff, Rachel, Alexander, Leigh, Biegel, Hannah, Skalshøi Kjær, Mette, Mørch Harder, Lea, Davidsen, Peter, Mikkelsen, Lars Frii, Balp, Maria-Magdalena, Brass, Clifford, Jennings, Lori, Martic, Miljen, Löffler, Jürgen, Applegate, Dougla, Shankar, Sudha, Torstenson, Richard, Fournier-Poizat, Céline, Llorca, Anne, Kalutkiewicz, Michael, Pepin, Kay, Ehman, Richard, Horan, Gerald, Ho, Gideon, Tai, Dean, Chng, Elaine, Patterson, Scott D., Billin, Andrew, Doward, Lynda, Twiss, Jame, Thakker, Paresh, Landgren, Henrik, Lackner, Carolin, Gouw, Annette, Hytiroglou, Prodromos, Luca, Miele (ORCID:0000-0003-3464-0068), Jenny, Lee, Max, Westphal, Yasaman, Vali, Jerome, Boursier, Salvatorre, Petta, Rachel, Ostroff, Leigh, Alexander, Yu, Chen, Celine, Fournier, Andreas, Geier, Sven, Francque, Kristy, Wonder, Dina, Tiniako, Pierre, Bedossa, Mike, Allison, Georgios, Papatheodoridi, Helena, Cortez-Pinto, Raluca, Pai, Jean-Francois, Dufour, Diana Julie, Leeming, Stephen, Harrison, Jeremy, Cobbold, Adriaan G, Holleboom, Hannele, Yki-Järvinen, Javier, Crespo, Mattias, Ekstedt, Guruprasad P, Aithal, Elisabetta, Bugianesi, Manuel, Romero-Gomez, Richard, Torstenson, Morten, Karsdal, Carla, Yuni, Jörn M, Schattenberg, Detlef, Schuppan, Vlad, Ratziu, Clifford, Bra, Kevin, Duffin, Koos, Zwinderman, Michael, Pavlide, Quentin M, Anstee, Patrick M, Bossuyt, Anstee, Quentin M., Daly, Ann K., Govaere, Olivier, Cockell, Simon, Tiniakos, Dina, Bedossa, Pierre, Burt, Alastair, Oakley, Fiona, Cordell, Heather J., Day, Christopher P., Wonders, Kristy, Missier, Paolo, Mcteer, Matthew, Vale, Luke, Oluboyede, Yemi, Breckons, Matt, Bossuyt, Patrick M., Zafarmand, Hadi, Vali, Yasaman, Lee, Jenny, Nieuwdorp, Max, Holleboom, Adriaan G., Verheij, Joanne, Ratziu, Vlad, Clément, Karine, Patino-Navarrete, Rafael, Pais, Raluca, Paradis, Valerie, Schuppan, Detlef, Schattenberg, Jörn M., Surabattula, Rambabu, Myneni, Sudha, Straub, Beate K., Vidal-Puig, Toni, Vacca, Michele, Rodrigues-Cuenca, Sergio, Allison, Mike, Kamzolas, Ioanni, Petsalaki, Evangelia, Campbell, Mark, Lelliott, Chris J., Davies, Susan, Orešič, Matej, Hyötyläinen, Tuulia, Mcglinchey, Aiden, Mato, Jose M., Millet, Óscar, Dufour, Jean-Françoi, Berzigotti, Annalisa, Masoodi, Mojgan, Pavlides, Michael, Harrison, Stephen, Neubauer, Stefan, Cobbold, Jeremy, Mozes, Ferenc, Akhtar, Salma, Olodo-Atitebi, Seliat, Banerjee, Rajarshi, Kelly, Matt, Shumbayawonda, Elizabeth, Dennis, Andrea, Andersson, Anneli, Wigley, Ioan, Romero-Gómez, Manuel, Gómez-González, Emilio, Ampuero, Javier, Castell, Javier, Gallego-Durán, Rocío, Fernández, Isabel, Montero-Vallejo, Rocío, Karsdal, Morten, Guldager Kring Rasmussen, Daniel, Leeming, Diana Julie, Sinisi, Antonia, Musa, Kishwar, Sandt, Estelle, Tonini, Manuela, Bugianesi, Elisabetta, Rosso, Chiara, Armandi, Angelo, Marra, Fabio, Gastaldelli, Amalia, Svegliati, Gianluca, Boursier, Jérôme, Francque, Sven, Vonghia, Luisa, Driessen, Ann, Ekstedt, Mattia, Kechagias, Stergio, Yki-Järvinen, Hannele, Porthan, Kimmo, Arola, Johanna, van Mil, Saskia, Papatheodoridis, George, Cortez-Pinto, Helena, Rodrigues, Cecilia M. P., Valenti, Luca, Pelusi, Serena, Petta, Salvatore, Pennisi, Grazia, Miele, Luca, Geier, Andrea, Trautwein, Christian, Aithal, Guruprasad P., Francis, Susan, Hockings, Paul, Schneider, Moritz, Newsome, Philip, Hübscher, Stefan, Wenn, David, Rosenquist, Christian, Trylesinski, Aldo, Mayo, Rebeca, Alonso, Cristina, Duffin, Kevin, Perfield, James W., Chen, Yu, Yunis, Carla, Tuthill, Theresa, Harrington, Magdalena Alicia, Miller, Melissa, Chen, Yan, Mcleod, Euan Jame, Ross, Trenton, Bernardo, Barbara, Schölch, Corinna, Ertle, Judith, Younes, Ramy, Oldenburger, Anouk, Ostroff, Rachel, Alexander, Leigh, Biegel, Hannah, Skalshøi Kjær, Mette, Mørch Harder, Lea, Davidsen, Peter, Mikkelsen, Lars Frii, Balp, Maria-Magdalena, Brass, Clifford, Jennings, Lori, Martic, Miljen, Löffler, Jürgen, Applegate, Dougla, Shankar, Sudha, Torstenson, Richard, Fournier-Poizat, Céline, Llorca, Anne, Kalutkiewicz, Michael, Pepin, Kay, Ehman, Richard, Horan, Gerald, Ho, Gideon, Tai, Dean, Chng, Elaine, Patterson, Scott D., Billin, Andrew, Doward, Lynda, Twiss, Jame, Thakker, Paresh, Landgren, Henrik, Lackner, Carolin, Gouw, Annette, Hytiroglou, Prodromos, and Luca, Miele (ORCID:0000-0003-3464-0068)
Abstract: Background and aims: Detecting NASH remains challenging, while at-risk NASH (steatohepatitis and F≥ 2) tends to progress and is of interest for drug development and clinical application. We developed prediction models by supervised machine learning techniques, with clinical data and biomarkers to stage and grade patients with NAFLD. Approach and results: Learning data were collected in the Liver Investigation: Testing Marker Utility in Steatohepatitis metacohort (966 biopsy-proven NAFLD adults), staged and graded according to NASH CRN. Conditions of interest were the clinical trial definition of NASH (NAS ≥ 4;53%), at-risk NASH (NASH with F ≥ 2;35%), significant (F ≥ 2;47%), and advanced fibrosis (F ≥ 3;28%). Thirty-five predictors were included. Missing data were handled by multiple imputations. Data were randomly split into training/validation (75/25) sets. A gradient boosting machine was applied to develop 2 models for each condition: clinical versus extended (clinical and biomarkers). Two variants of the NASH and at-risk NASH models were constructed: direct and composite models.Clinical gradient boosting machine models for steatosis/inflammation/ballooning had AUCs of 0.94/0.79/0.72. There were no improvements when biomarkers were included. The direct NASH model produced AUCs (clinical/extended) of 0.61/0.65. The composite NASH model performed significantly better (0.71) for both variants. The composite at-risk NASH model had an AUC of 0.83 (clinical and extended), an improvement over the direct model. Significant fibrosis models had AUCs (clinical/extended) of 0.76/0.78. The extended advanced fibrosis model (0.86) performed significantly better than the clinical version (0.82). Conclusions: Detection of NASH and at-risk NASH can be improved by constructing independent machine learning models for each component, using only clinical predictors. Adding biomarkers only improved the accuracy of fibrosis.
Published: 2023

74. Corrigendum to 'Non-alcoholic fatty liver disease in adults 2021: A clinical practice guideline of the Italian Association for the Study of the Liver (AISF), the Italian Society of Diabetology (SID) and the Italian Society of Obesity (SIO)' [Dig Liver Dis 54 (2022) 170-182]

Author: Marchesini, G., Bugianesi, E., Burra, P., Marra, F., Miele, Luca, Alisi, A., Vajro, P., Masarone, M., Petta, S., Persico, M., Svegliati-Baroni, G., Valenti, L., Federici, M., Purrello, F., Sasso, F. C., Targher, G., Busetto, L., Petroni, M. L., Santini, F., Camma, C., Colli, A., Miele L. (ORCID:0000-0003-3464-0068), Marchesini, G., Bugianesi, E., Burra, P., Marra, F., Miele, Luca, Alisi, A., Vajro, P., Masarone, M., Petta, S., Persico, M., Svegliati-Baroni, G., Valenti, L., Federici, M., Purrello, F., Sasso, F. C., Targher, G., Busetto, L., Petroni, M. L., Santini, F., Camma, C., Colli, A., and Miele L. (ORCID:0000-0003-3464-0068)
Abstract: N/A
Published: 2023

75. The role of antiplatelet therapies on incidence and mortality of hepatocellular carcinoma

Author: Lai, Quirino, De Matthaeis, Nicoletta, Finotti, Michele, Galati, Giovanni, Marrone, Giuseppe, Melandro, Fabio, Morisco, Filomena, Nicolini, Daniele, Pravisani, Riccardo, Giannini, Edoardo G, Aglitti, A, Aliberti, C, Baccarani, U, Bhoori, S, Borzio, M, Brancaccio, G, Burra, P, Cabibbo, G, Casadei Gardini, A, Carrai, P, Cillo, U, Conti, F, Cucchetti, A, D'Ambrosio, R, Dell'Unto, C, Di Costanzi, Gg, Di Sandro, S, Foschi, Fg, Fucilli, F, Gambato, M, Gasbarrini, Antonio, Giuliante, Felice, Ghinolfi, D, Grieco, Antonio, Gruttaduria, S, Guarino, M, Kostandini, A, Iavarone, M, Lenci, I, Levi Sandri, Gb, Losito, F, Lupo, Lg, Manzia, Tm, Mazzocato, S, Mescoli, C, Miele, Luca, Muley, M, Persico, M, Plaz Torres, Mc, Pompili, Maurizio, Ponziani, Francesca Romana, Rapaccini, Gian Ludovico, Rendina, M, Renzulli, M, Rossi, Marco, Rreka, E, Russo, Fp, Sacco, R, Sangiovanni, A, Sessa, A, Simonetti, N, Sposito, C, Tortora, R, Trevisani, F, Viganò, L, Viganò, M, Villa, E, Vincenzi, V, Violi, P, Vitale, A, Gasbarrini, A (ORCID:0000-0002-7278-4823), Giuliante, F (ORCID:0000-0001-9517-8220), Grieco, A (ORCID:0000-0002-0544-8993), Miele, L (ORCID:0000-0003-3464-0068), Pompili, M (ORCID:0000-0001-6699-7980), Ponziani, FR (ORCID:0000-0002-5924-6238), Rapaccini, GL (ORCID:0000-0002-6467-857X), Rossi, M (ORCID:0000-0002-4539-5670), Lai, Quirino, De Matthaeis, Nicoletta, Finotti, Michele, Galati, Giovanni, Marrone, Giuseppe, Melandro, Fabio, Morisco, Filomena, Nicolini, Daniele, Pravisani, Riccardo, Giannini, Edoardo G, Aglitti, A, Aliberti, C, Baccarani, U, Bhoori, S, Borzio, M, Brancaccio, G, Burra, P, Cabibbo, G, Casadei Gardini, A, Carrai, P, Cillo, U, Conti, F, Cucchetti, A, D'Ambrosio, R, Dell'Unto, C, Di Costanzi, Gg, Di Sandro, S, Foschi, Fg, Fucilli, F, Gambato, M, Gasbarrini, Antonio, Giuliante, Felice, Ghinolfi, D, Grieco, Antonio, Gruttaduria, S, Guarino, M, Kostandini, A, Iavarone, M, Lenci, I, Levi Sandri, Gb, Losito, F, Lupo, Lg, Manzia, Tm, Mazzocato, S, Mescoli, C, Miele, Luca, Muley, M, Persico, M, Plaz Torres, Mc, Pompili, Maurizio, Ponziani, Francesca Romana, Rapaccini, Gian Ludovico, Rendina, M, Renzulli, M, Rossi, Marco, Rreka, E, Russo, Fp, Sacco, R, Sangiovanni, A, Sessa, A, Simonetti, N, Sposito, C, Tortora, R, Trevisani, F, Viganò, L, Viganò, M, Villa, E, Vincenzi, V, Violi, P, Vitale, A, Gasbarrini, A (ORCID:0000-0002-7278-4823), Giuliante, F (ORCID:0000-0001-9517-8220), Grieco, A (ORCID:0000-0002-0544-8993), Miele, L (ORCID:0000-0003-3464-0068), Pompili, M (ORCID:0000-0001-6699-7980), Ponziani, FR (ORCID:0000-0002-5924-6238), Rapaccini, GL (ORCID:0000-0002-6467-857X), and Rossi, M (ORCID:0000-0002-4539-5670)
Abstract: Aim To evaluate the impact of antiplatelet therapy (APT)on the incidence of hepatocellular carcinoma (HCC) and mortality following its treatment. Methods A systematic literature search was performed using PubMed and Cochrane Central Register of Controlled Trials Databases. Two HCC clinical settings were explored: (i) incidence, and (ii) death after any HCC treatment. Odds ratios (OR) and 95% confidence intervals (95%CI) were calculated to compare the pooled data between patients who received or did not receive APT. Results A total of 20 studies were identified, of whom 15 focused on HCC incidence, including 2,685,009 patients, and five on post-treatment death, including 3281 patients. APT was associated with an overall reduced risk of HCC incidence (OR: 0.63; 95%CI = 0.51-0.79; p < 0.001) as well as of post-treatment mortality (OR: 0.54; 95%CI = 0.35-0.83; p = 0.006). Conclusions Current data suggest that APT correlated with higher HCC incidence and poor overall survival following tumour treatment.
Published: 2023

76. Autoimmunity and lymphoproliferation markers in naïve HCV-RNA positive patients without clinical evidences of autoimmune/lymphoproliferative disorders

Author: Gulli, Francesca, Basile, Umberto, Gragnani, Laura, Fognani, Elisa, Napodano, Cecilia, Colacicco, Luigi, Miele, Luca, De Matthaeis, Nicoletta, Cattani, Paola, Zignego, Anna Linda, and Rapaccini, Gian Ludovico
Published: 2016
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77. A “systems medicine” approach to the study of non-alcoholic fatty liver disease

Author: Ferrannini, Ele, Loguercio, Carmela, Lonardo, Amedeo, Marra, Fabio, Mancini, Marcello, Miele, Luca, Nobili, Valerio, Baroni, Gianluca Svegliati, Alessandro, Federico, Ballestri, Stefano, Rossana Brunetto, Maurizia, Coco, Barbara, Grieco, Antonio, Fargion, Silvia, Kondili, Loreta, Nascimbeni, Fabio, Prinster, Anna, Romagnoli, Dante, Taddei, Stefano, Vanni, Ester, Vella, Stefano, Petta, Salvatore, Valenti, Luca, Bugianesi, Elisabetta, Targher, Giovanni, Bellentani, Stefano, and Bonino, Ferruccio
Published: 2016
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78. FibroGENE: A gene-based model for staging liver fibrosis

Author: Eslam, Mohammed, Hashem, Ahmed M., Romero-Gomez, Manuel, Berg, Thomas, Dore, Gregory J., Mangia, Alessandra, Chan, Henry Lik Yuen, Irving, William L., Sheridan, David, Abate, Maria Lorena, Adams, Leon A., Weltman, Martin, Bugianesi, Elisabetta, Spengler, Ulrich, Shaker, Olfat, Fischer, Janett, Mollison, Lindsay, Cheng, Wendy, Nattermann, Jacob, Riordan, Stephen, Miele, Luca, Kelaeng, Kebitsaone Simon, Ampuero, Javier, Ahlenstiel, Golo, McLeod, Duncan, Powell, Elizabeth, Liddle, Christopher, Douglas, Mark W., Booth, David R., and George, Jacob
Published: 2016
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79. Epidemiological modifiers of non-alcoholic fatty liver disease: Focus on high-risk groups

Author: Lonardo, Amedeo, Bellentani, Stefano, Argo, Curtis K., Ballestri, Stefano, Byrne, Christopher D., Caldwell, Stephen H., Cortez-Pinto, Helena, Grieco, Antonio, Machado, Mariana V., Miele, Luca, and Targher, Giovanni
Published: 2015
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80. Rare Pathogenic Variants Predispose to Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease

Author: Pelusi, Serena, Baselli, Guido, Pietrelli, Alessandro, Dongiovanni, Paola, Donati, Benedetta, McCain, Misti Vanette, Meroni, Marica, Fracanzani, Anna Ludovica, Romagnoli, Renato, Petta, Salvatore, Grieco, Antonio, Miele, Luca, Soardo, Giorgio, Bugianesi, Elisabetta, Fargion, Silvia, Aghemo, Alessio, D’Ambrosio, Roberta, Xing, Chao, Romeo, Stefano, De Francesco, Raffaele, Reeves, Helen Louise, and Valenti, Luca Vittorio Carlo
Published: 2019
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81. Fever of unknown origin due to Coxiella burnetii, an unexpected guest in primary sclerosing cholangitis

Author: Cerrito, Lucia, primary, Guidi, Luisa, additional, Vecchio, Fabio M., additional, and Miele, Luca, additional
Published: 2023
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82. Watery stools and metabolic acidosis

Author: Ferrari, Maria Chiara, Miele, Luca, Guidi, Luisa, Rindi, Guido, Rocchi, Carlo, Castaldi, Paola, Alfieri, Sergio, Gasbarrini, Antonio, Grieco, Antonio, and Rapaccini, Gianlodovico
Published: 2017
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83. Non‐alcoholic fatty liver disease and the risk of fibrosis in Italian primary care services

Author: Miele, Luca, primary, Grattagliano, Ignazio, additional, Lapi, Francesco, additional, Dajko, Marianxhela, additional, De Magistris, Antonio, additional, Liguori, Antonio, additional, De Matthaeis, Nicoletta, additional, Rossi, Alessandro, additional, Gasbarrini, Antonio, additional, Cricelli, Claudio, additional, and Grieco, Antonio, additional
Published: 2022
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84. Editorial: The broader aspects of non-alcoholic fatty liver disease in children

Author: Mandato, Claudia, primary, Miele, Luca, additional, Socha, Piotr, additional, and Vajro, Pietro, additional
Published: 2022
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85. Rare ATG7 genetic variants predispose patients to severe fatty liver disease

Author: Baselli, Guido A., primary, Jamialahmadi, Oveis, additional, Pelusi, Serena, additional, Ciociola, Ester, additional, Malvestiti, Francesco, additional, Saracino, Marco, additional, Santoro, Luigi, additional, Cherubini, Alessandro, additional, Dongiovanni, Paola, additional, Maggioni, Marco, additional, Bianco, Cristiana, additional, Tavaglione, Federica, additional, Cespiati, Annalisa, additional, Mancina, Rosellina M., additional, D’Ambrosio, Roberta, additional, Vaira, Valentina, additional, Petta, Salvatore, additional, Miele, Luca, additional, Vespasiani-Gentilucci, Umberto, additional, Federico, Alessandro, additional, Pihlajamaki, Jussi, additional, Bugianesi, Elisabetta, additional, Fracanzani, Anna L., additional, Reeves, Helen L., additional, Soardo, Giorgio, additional, Prati, Daniele, additional, Romeo, Stefano, additional, Valenti, Luca VC., additional, Borroni, Vittorio, additional, Liguori, Antonio, additional, Ronzoni, Luisa, additional, Tomasi, Melissa, additional, Lombardi, Angela, additional, Ostadreza, Mahnoosh, additional, Casirati, Elia, additional, Marini, Ilaria, additional, Maier, Silvia, additional, Rosso, Chiara, additional, Baroni, Gianluca Svegliati, additional, Santaniello, Carlo, additional, and Dallio, Marcello, additional
Published: 2022
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86. Intestinal permeability is increased in children with non-alcoholic fatty liver disease, and correlates with liver disease severity

Author: Giorgio, Valentina, Miele, Luca, Principessa, Luigi, Ferretti, Francesca, Villa, Maria Pia, Negro, Valentina, Grieco, Antonio, Alisi, Anna, and Nobili, Valerio
Published: 2014
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87. Risk of burnout and stress in physicians working in a COVID team: A longitudinal survey

Author: Dionisi, Tommaso, Sestito, Luisa, Tarli, Claudia, Antonelli, Mariangela, Tosoni, Alberto, D'Addio, Stefano, Mirijello, Antonio, Vassallo, Gabriele Angelo, Leggio, Lorenzo, Gasbarrini, Antonio, Addolorato, Giovanni, Miele, Luca, Bosello, Silvia Laura, Gemelli Against COVID-19, Group, Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Addolorato, Giovanni (ORCID:0000-0002-1522-9946), Miele, Luca (ORCID:0000-0003-3464-0068), Bosello, Silvia (ORCID:0000-0002-4837-447X), Dionisi, Tommaso, Sestito, Luisa, Tarli, Claudia, Antonelli, Mariangela, Tosoni, Alberto, D'Addio, Stefano, Mirijello, Antonio, Vassallo, Gabriele Angelo, Leggio, Lorenzo, Gasbarrini, Antonio, Addolorato, Giovanni, Miele, Luca, Bosello, Silvia Laura, Gemelli Against COVID-19, Group, Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Addolorato, Giovanni (ORCID:0000-0002-1522-9946), Miele, Luca (ORCID:0000-0003-3464-0068), and Bosello, Silvia (ORCID:0000-0002-4837-447X)
Abstract: Background and aims The COVID-19 pandemic represents a source of stress and potential burnout for many physicians. This single-site survey aimed at assessing perceived stress and risk to develop burnout syndrome among physicians operating in COVID wards. Methods This longitudinal survey evaluated stress and burnout in 51 physicians operating in the COVID team of Gemelli Hospital, Italy. Participants were asked to complete the Maslach Burnout Inventory (MBI) and the Perceived Stress Questionnaire on a short run (PSQs) (referring to the past 7 days) at baseline (T0) and then for four weeks (T1-T4). Perceived Stress Questionnaire on a long run (PSQl) (referring to the past 2 years) was completed only at T0. Results Compared with physicians board-certified in internal medicine, those board-certified in other disciplines showed higher scores for the Emotional Exhaustion (EE) score of the MBI scale (P < .001). Depersonalisation (DP) score showed a reduction over time (P = .002). Attending physicians scored lower than the resident physicians on the DP scale (P = .048) and higher than resident physicians on the Personal Accomplishment (PA) scale (P = .04). PSQl predicted higher scores on the EE scale (P = .003), DP scale (P = .003) and lower scores on the PA scale (P < .001). PSQs showed a reduction over time (P = .03). Attending physicians had a lower PSQs score compared with the resident physicians (P = .04). Conclusions Medical specialty and clinical position could represent risk factors for the development of burnout in a COVID team. In these preliminary results, physicians board-certified in internal medicine showed lower risk of developing EE during the entire course of the study.
Published: 2021

88. Long-term outcomes and predictive ability of non-invasive scoring systems in patients with non-alcoholic fatty liver disease

Author: Younes, Ramy, Caviglia, Gian Paolo, Govaere, Olivier, Rosso, Chiara, Armandi, Angelo, Sanavia, Tiziana, Pennisi, Grazia, Liguori, Antonio, Francione, Paolo, Gallego-Durán, Rocío, Ampuero, Javier, Garcia Blanco, Maria J, Aller, Rocio, Tiniakos, Dina, Burt, Alastair, David, Ezio, Vecchio, Fabio Maria, Maggioni, Marco, Cabibi, Daniela, Pareja, María Jesú, Zaki, Marco Y W, Grieco, Antonio, Fracanzani, Anna L, Valenti, Luca, Miele, Luca, Fariselli, Piero, Petta, Salvatore, Romero-Gomez, Manuel, Anstee, Quentin M, Bugianesi, Elisabetta, Vecchio, Fabio M (ORCID:0000-0002-9197-2264), Grieco, Antonio (ORCID:0000-0002-0544-8993), Miele, Luca (ORCID:0000-0003-3464-0068), Younes, Ramy, Caviglia, Gian Paolo, Govaere, Olivier, Rosso, Chiara, Armandi, Angelo, Sanavia, Tiziana, Pennisi, Grazia, Liguori, Antonio, Francione, Paolo, Gallego-Durán, Rocío, Ampuero, Javier, Garcia Blanco, Maria J, Aller, Rocio, Tiniakos, Dina, Burt, Alastair, David, Ezio, Vecchio, Fabio Maria, Maggioni, Marco, Cabibi, Daniela, Pareja, María Jesú, Zaki, Marco Y W, Grieco, Antonio, Fracanzani, Anna L, Valenti, Luca, Miele, Luca, Fariselli, Piero, Petta, Salvatore, Romero-Gomez, Manuel, Anstee, Quentin M, Bugianesi, Elisabetta, Vecchio, Fabio M (ORCID:0000-0002-9197-2264), Grieco, Antonio (ORCID:0000-0002-0544-8993), and Miele, Luca (ORCID:0000-0003-3464-0068)
Abstract: Background & Aims: Non-invasive scoring systems (NSS) are used to identify patients with non-alcoholic fatty liver disease (NAFLD) who are at risk of advanced fibrosis, but their reliability in predicting long-term outcomes for hepatic/extrahepatic complications or death and their concordance in cross-sectional and longitudinal risk stratification remain uncertain.Methods: The most common NSS (NFS, FIB-4, BARD, APRI) and the Hepamet fibrosis score (HFS) were assessed in 1,173 European patients with NAFLD from tertiary centres. Performance for fibrosis risk stratification and for the prediction of long-term hepatic/extrahepatic events, hepatocarcinoma (HCC) and overall mortality were evaluated in terms of AUC and Harrell's c-index. For longitudinal data, NSS-based Cox proportional hazard models were trained on the whole cohort with repeated 5-fold cross-validation, sampling for testing from the 607 patients with all NSS available.Results: Cross-sectional analysis revealed HFS as the best performer for the identification of significant (F0-1 vs. F2-4, AUC = 0.758) and advanced (F0-2 vs. F3-4, AUC = 0.805) fibrosis, while NFS and FIB-4 showed the best performance for detecting histological cirrhosis (range AUCs 0.85-0.88). Considering longitudinal data (follow-up between 62 and 110 months), NFS and FIB-4 were the best at predicting liver-related events (c-indices>0.7), NFS for HCC (c-index = 0.9 on average), and FIB-4 and HFS for overall mortality (c-indices >0.8). All NSS showed limited performance (c-indices <0.7) for extrahepatic events.Conclusions: Overall, NFS, HFS and FIB-4 outperformed APRI and BARD for both cross-sectional identification of fibrosis and prediction of long-term outcomes, confirming that they are useful tools for the clinical management of patients with NAFLD at increased risk of fibrosis and liver-related complications or death.Lay summary: Non-invasive scoring systems are increasingly being used in patients with non-alcoholic fatty
Published: 2021

89. Epidemiological trends and trajectories of MAFLD-associated hepatocellular carcinoma 2002-2033: the ITA.LI.CA database

Author: Vitale, Alessandro, Svegliati-Baroni, Gianluca, Ortolani, Alessio, Cucco, Monica, Dalla Riva, Giulio V, Giannini, Edoardo G, Piscaglia, Fabio, Rapaccini, Gianludovico, Di Marco, Mariella, Caturelli, Eugenio, Zoli, Marco, Sacco, Rodolfo, Cabibbo, Giuseppe, Marra, Fabio, Mega, Andrea, Morisco, Filomena, Gasbarrini, Antonio, Foschi, Francesco Giuseppe, Missale, Gabriele, Masotto, Alberto, Nardone, Gerardo, Raimondo, Giovanni, Azzaroli, Francesco, Vidili, Gianpaolo, Oliveri, Filippo, Pelizzaro, Filippo, Ramirez Morales, Rafael, Cillo, Umberto, Trevisani, Franco, Miele, Luca, Marchesini, Giulio, Farinati, Fabio, Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Miele, Luca (ORCID:0000-0003-3464-0068), Vitale, Alessandro, Svegliati-Baroni, Gianluca, Ortolani, Alessio, Cucco, Monica, Dalla Riva, Giulio V, Giannini, Edoardo G, Piscaglia, Fabio, Rapaccini, Gianludovico, Di Marco, Mariella, Caturelli, Eugenio, Zoli, Marco, Sacco, Rodolfo, Cabibbo, Giuseppe, Marra, Fabio, Mega, Andrea, Morisco, Filomena, Gasbarrini, Antonio, Foschi, Francesco Giuseppe, Missale, Gabriele, Masotto, Alberto, Nardone, Gerardo, Raimondo, Giovanni, Azzaroli, Francesco, Vidili, Gianpaolo, Oliveri, Filippo, Pelizzaro, Filippo, Ramirez Morales, Rafael, Cillo, Umberto, Trevisani, Franco, Miele, Luca, Marchesini, Giulio, Farinati, Fabio, Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), and Miele, Luca (ORCID:0000-0003-3464-0068)
Abstract: Background Metabolic dysfunction-associated fatty liver disease (MAFLD) represents a new inclusive definition of the whole spectrum of liver diseases associated to metabolic disorders. The main objective of this study was to compare patients with MAFLD and non-MAFLD with hepatocellular carcinoma (HCC) included in a nationally representative cohort. Methods We analysed 6882 consecutive patients with HCC enrolled from 2002 to 2019 by 23 Italian Liver Cancer centres to compare epidemiological and future trends in three subgroups: pure, single aetiology MAFLD (S-MAFLD); mixed aetiology MAFLD (metabolic and others, M-MAFLD); and non-MAFLD HCC. Results MAFLD was diagnosed in the majority of patients with HCC (68.4%). The proportion of both total MAFLD and S-MAFLD HCC significantly increased over time (from 50.4% and 3.6% in 2002-2003, to 77.3% and 28.9% in 2018-2019, respectively, p<0.001). In Italy S-MAFLD HCC is expected to overcome M-MAFLD HCC in about 6 years. Patients with S-MAFLD HCC were older, more frequently men and less frequently cirrhotic with clinically relevant portal hypertension and a surveillance-related diagnosis. They had more frequently large tumours and extrahepatic metastases. After weighting, and compared with patients with non-MAFLD, S-MAFLD and M-MAFLD HCC showed a significantly lower overall (p=0.026, p=0.004) and HCC-related (p<0.001, for both) risk of death. Patients with S-MAFLD HCC showed a significantly higher risk of non-HCC-related death (p=0.006). Conclusions The prevalence of MAFLD HCC in Italy is rapidly increasing to cover the majority of patients with HCC. Despite a less favourable cancer stage at diagnosis, patients with MAFLD HCC have a lower risk of HCC-related death, suggesting reduced cancer aggressiveness.
Published: 2021

90. Solving the mystery of HBV-related mixed cryoglobulinemia: potential biomarkers of disease progression

Author: Pocino, Krizia, Napodano, Cecilia, Gragnani, Laura, Ciasca, Gabriele, Colantuono, Stefania, Marri, Silvia, Vantaggio, Lorenzo, Gulli, Francesca, Lorini, Serena, Barini, Antonella, Stefanile, Annunziata, Miele, Luca, Casato, Milvia, Zignego, Anna Linda, Rapaccini, Gian Ludovico, Marino, Mariapaola, Visentini, Marcella, Basile, Umberto, Pocino, Krizia (ORCID:0000-0003-2456-5308), Napodano, Cecilia (ORCID:0000-0002-8720-6284), Ciasca, Gabriele (ORCID:0000-0002-3694-8229), Miele, Luca (ORCID:0000-0003-3464-0068), Rapaccini, Gian Ludovico (ORCID:0000-0002-6467-857X), Marino, Mariapaola (ORCID:0000-0001-9155-6378), Pocino, Krizia, Napodano, Cecilia, Gragnani, Laura, Ciasca, Gabriele, Colantuono, Stefania, Marri, Silvia, Vantaggio, Lorenzo, Gulli, Francesca, Lorini, Serena, Barini, Antonella, Stefanile, Annunziata, Miele, Luca, Casato, Milvia, Zignego, Anna Linda, Rapaccini, Gian Ludovico, Marino, Mariapaola, Visentini, Marcella, Basile, Umberto, Pocino, Krizia (ORCID:0000-0003-2456-5308), Napodano, Cecilia (ORCID:0000-0002-8720-6284), Ciasca, Gabriele (ORCID:0000-0002-3694-8229), Miele, Luca (ORCID:0000-0003-3464-0068), Rapaccini, Gian Ludovico (ORCID:0000-0002-6467-857X), and Marino, Mariapaola (ORCID:0000-0001-9155-6378)
Abstract: OBJECTIVES: The biomarkers of an immunological dysregulation due to a chronic Hepatitis B virus (HBV) infection are indeed understudied. If untreated, this condition may evolve into liver impairment also co-occurred by extrahepatic involvements. Here, we aim to identify a new panel of biomarkers including IgG subclasses, Rheumatoid Factor (RF), and Free Light Chains (FLC) that may result useful and reliable for clinical evaluation of HBV-related cryoglobulinemia.METHODS: We retrospectively analyzed clinical data from 44 HBV positive patients. Patients were stratified on the presence/absence of mixed cryoglobulinemia in two group: 22 with cryoglobulins (CGs) and 22 without CGs. Samples from 20 healthy blood donors (HD) were used as negative controls. Serum samples were tested for IgG subclasses, RF (IgM, IgG, and IgA type), and FLC.RESULTS: We detected a strikingly different serum IgG subclasses distribution between HD and HBV positive patients together with different RF isotypes; FLC were significantly increased in HBV-patients if compared with HD while no significant difference was shown between HBV with/without MC.CONCLUSION: The immune-inflammatory response triggered by HBV may be monitored by a peculiar profile of biomarkers. Our results open new perspective in precision medicine era; in these challenging times, they could be also employed to monitor the clinical course of COVID-19 patients, at high risk of HBV reactivation due to liver impairment and/or immunosuppressive therapies.
Published: 2021

91. A machine-learning parsimonious multivariable predictive model of mortality risk in patients with Covid-19

Author: Murri, Rita, Lenkowicz, Jacopo, Masciocchi, Carlotta, Iacomini, Chiara, Fantoni, Massimo, Damiani, Andrea, Marchetti, Antonio, Sergi, Paolo Domenico Angelo, Arcuri, Giovanni, Cesario, Alfredo, Patarnello, Stefano, Antonelli, Massimo, Bellantone, Rocco Domenico Alfonso, Bernabei, Roberto, Boccia, Stefania, Calabresi, Paolo, Cambieri, Andrea, Cauda, Roberto, Colosimo, Cesare, Crea, Filippo, De Maria Marchiano, Ruggero, De Stefano, Valerio, Franceschi, Francesco, Gasbarrini, Antonio, Parolini, Ornella, Richeldi, Luca, Sanguinetti, Maurizio, Urbani, Andrea, Zega, Maurizio, Scambia, Giovanni, Valentini, Vincenzo, Armuzzi, Alessandro, Barba, Marta, Baroni, Silvia, Bellesi, Silvia, Bentivoglio, Annarita, Biasucci, Luigi Marzio, Biscetti, Federico, Candelli, Marcello, Capalbo, Gennaro, Cattani Franchi, Paola, Chiusolo, Patrizia, Cingolani, Antonella, Corbo, Giuseppe Maria, Covino, Marcello, Cozzolino, Angela Maria, D’Alfonso, Marilena, De Angelis, Giulia, De Pascale, Gennaro, Frisullo, Giovanni, Gabrielli, Maurizio, Gambassi, Giovanni, Garcovich, Matteo, Gremese, Elisa, Grieco, Domenico Luca, Iaconelli, Amerigo, Iorio, Raffaele, Landi, Francesco, Larici, Annarita, Liuzzo, Giovanna, Maviglia, Riccardo, Miele, Luca, Montalto, Massimo, Natale, Luigi, Nicolotti, Nicola, Ojetti, Veronica, Pompili, Maurizio, Posteraro, Brunella, Rapaccini, Gianni, Rinaldi, Riccardo, Rossi, Elena, Santoliquido, Angelo, Sica, Simona, Tamburrini, Enrica, Teofili, Luciana, Testa, Antonia Carla, Tosoni, Alberto, Trani, Carlo, Varone, Francesco, Zileri Dal Verme, Lorenzo, Null, Null, Murri, Rita (ORCID:0000-0003-4263-7854), Fantoni, Massimo (ORCID:0000-0001-6913-8460), Cesario, Alfredo (ORCID:0000-0003-4687-0709), Antonelli, Massimo (ORCID:0000-0003-3007-1670), Bellantone, Rocco (ORCID:0000-0002-0844-3469), Bernabei, Roberto (ORCID:0000-0002-9197-004X), Boccia, Stefania (ORCID:0000-0002-1864-749X), Calabresi, Paolo (ORCID:0000-0003-0326-5509), Cauda, Roberto (ORCID:0000-0002-1498-4229), Colosimo, Cesare (ORCID:0000-0003-3800-3648), Crea, Filippo (ORCID:0000-0001-9404-8846), De Maria, Ruggero (ORCID:0000-0003-2255-0583), De Stefano, Valerio (ORCID:0000-0002-5178-5827), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Parolini, Ornella (ORCID:0000-0002-5211-6430), Richeldi, Luca (ORCID:0000-0001-8594-1448), Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), Zega, Maurizio (ORCID:0000-0002-7821-2615), Scambia, Giovanni (ORCID:0000-0003-2758-1063), Valentini, Vincenzo (ORCID:0000-0003-4637-6487), Armuzzi, Alessandro (ORCID:0000-0003-1572-0118), Barba, Marta (ORCID:0000-0001-6084-7666), Baroni, Silvia (ORCID:0000-0002-3410-2617), Biasucci, Luigi Marzio (ORCID:0000-0002-6921-6497), Biscetti, Federico (ORCID:0000-0001-7449-657X), Candelli, Marcello (ORCID:0000-0001-8443-7880), Cattani, Paola (ORCID:0000-0003-4678-4763), Chiusolo, Patrizia (ORCID:0000-0002-1355-1587), Cingolani, Antonella (ORCID:0000-0002-3793-2755), Corbo, Giuseppe (ORCID:0000-0002-8104-4659), Covino, Marcello (ORCID:0000-0002-6709-2531), De Angelis, Giulia (ORCID:0000-0002-7087-7399), De Pascale, Gennaro (ORCID:0000-0002-8255-0676), Gambassi, Giovanni (ORCID:0000-0002-7030-9359), Gremese, Elisa (ORCID:0000-0002-2248-1058), Grieco, Domenico Luca (ORCID:0000-0002-4557-6308), Iorio, Raffaele (ORCID:0000-0002-6270-0956), Landi, Francesco (ORCID:0000-0002-3472-1389), Liuzzo, Giovanna (ORCID:0000-0002-5714-0907), Miele, Luca (ORCID:0000-0003-3464-0068), Montalto, Massimo (ORCID:0000-0001-8819-3684), Natale, Luigi (ORCID:0000-0002-7949-5119), Ojetti, Veronica (ORCID:0000-0002-8953-0707), Pompili, Maurizio (ORCID:0000-0001-6699-7980), Posteraro, Brunella (ORCID:0000-0002-1663-7546), Rossi, Elena (ORCID:0000-0002-7572-9379), Santoliquido, Angelo (ORCID:0000-0003-1539-4017), Tamburrini, Enrica (ORCID:0000-0003-4930-426X), Teofili, Luciana (ORCID:0000-0002-7214-1561), Testa, Antonia (ORCID:0000-0003-2217-8726), Trani, Carlo (ORCID:0000-0001-9777-013X), Verme, Lorenzo Zileri Dal, Murri, Rita, Lenkowicz, Jacopo, Masciocchi, Carlotta, Iacomini, Chiara, Fantoni, Massimo, Damiani, Andrea, Marchetti, Antonio, Sergi, Paolo Domenico Angelo, Arcuri, Giovanni, Cesario, Alfredo, Patarnello, Stefano, Antonelli, Massimo, Bellantone, Rocco Domenico Alfonso, Bernabei, Roberto, Boccia, Stefania, Calabresi, Paolo, Cambieri, Andrea, Cauda, Roberto, Colosimo, Cesare, Crea, Filippo, De Maria Marchiano, Ruggero, De Stefano, Valerio, Franceschi, Francesco, Gasbarrini, Antonio, Parolini, Ornella, Richeldi, Luca, Sanguinetti, Maurizio, Urbani, Andrea, Zega, Maurizio, Scambia, Giovanni, Valentini, Vincenzo, Armuzzi, Alessandro, Barba, Marta, Baroni, Silvia, Bellesi, Silvia, Bentivoglio, Annarita, Biasucci, Luigi Marzio, Biscetti, Federico, Candelli, Marcello, Capalbo, Gennaro, Cattani Franchi, Paola, Chiusolo, Patrizia, Cingolani, Antonella, Corbo, Giuseppe Maria, Covino, Marcello, Cozzolino, Angela Maria, D’Alfonso, Marilena, De Angelis, Giulia, De Pascale, Gennaro, Frisullo, Giovanni, Gabrielli, Maurizio, Gambassi, Giovanni, Garcovich, Matteo, Gremese, Elisa, Grieco, Domenico Luca, Iaconelli, Amerigo, Iorio, Raffaele, Landi, Francesco, Larici, Annarita, Liuzzo, Giovanna, Maviglia, Riccardo, Miele, Luca, Montalto, Massimo, Natale, Luigi, Nicolotti, Nicola, Ojetti, Veronica, Pompili, Maurizio, Posteraro, Brunella, Rapaccini, Gianni, Rinaldi, Riccardo, Rossi, Elena, Santoliquido, Angelo, Sica, Simona, Tamburrini, Enrica, Teofili, Luciana, Testa, Antonia Carla, Tosoni, Alberto, Trani, Carlo, Varone, Francesco, Zileri Dal Verme, Lorenzo, Null, Null, Murri, Rita (ORCID:0000-0003-4263-7854), Fantoni, Massimo (ORCID:0000-0001-6913-8460), Cesario, Alfredo (ORCID:0000-0003-4687-0709), Antonelli, Massimo (ORCID:0000-0003-3007-1670), Bellantone, Rocco (ORCID:0000-0002-0844-3469), Bernabei, Roberto (ORCID:0000-0002-9197-004X), Boccia, Stefania (ORCID:0000-0002-1864-749X), Calabresi, Paolo (ORCID:0000-0003-0326-5509), Cauda, Roberto (ORCID:0000-0002-1498-4229), Colosimo, Cesare (ORCID:0000-0003-3800-3648), Crea, Filippo (ORCID:0000-0001-9404-8846), De Maria, Ruggero (ORCID:0000-0003-2255-0583), De Stefano, Valerio (ORCID:0000-0002-5178-5827), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Parolini, Ornella (ORCID:0000-0002-5211-6430), Richeldi, Luca (ORCID:0000-0001-8594-1448), Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), Zega, Maurizio (ORCID:0000-0002-7821-2615), Scambia, Giovanni (ORCID:0000-0003-2758-1063), Valentini, Vincenzo (ORCID:0000-0003-4637-6487), Armuzzi, Alessandro (ORCID:0000-0003-1572-0118), Barba, Marta (ORCID:0000-0001-6084-7666), Baroni, Silvia (ORCID:0000-0002-3410-2617), Biasucci, Luigi Marzio (ORCID:0000-0002-6921-6497), Biscetti, Federico (ORCID:0000-0001-7449-657X), Candelli, Marcello (ORCID:0000-0001-8443-7880), Cattani, Paola (ORCID:0000-0003-4678-4763), Chiusolo, Patrizia (ORCID:0000-0002-1355-1587), Cingolani, Antonella (ORCID:0000-0002-3793-2755), Corbo, Giuseppe (ORCID:0000-0002-8104-4659), Covino, Marcello (ORCID:0000-0002-6709-2531), De Angelis, Giulia (ORCID:0000-0002-7087-7399), De Pascale, Gennaro (ORCID:0000-0002-8255-0676), Gambassi, Giovanni (ORCID:0000-0002-7030-9359), Gremese, Elisa (ORCID:0000-0002-2248-1058), Grieco, Domenico Luca (ORCID:0000-0002-4557-6308), Iorio, Raffaele (ORCID:0000-0002-6270-0956), Landi, Francesco (ORCID:0000-0002-3472-1389), Liuzzo, Giovanna (ORCID:0000-0002-5714-0907), Miele, Luca (ORCID:0000-0003-3464-0068), Montalto, Massimo (ORCID:0000-0001-8819-3684), Natale, Luigi (ORCID:0000-0002-7949-5119), Ojetti, Veronica (ORCID:0000-0002-8953-0707), Pompili, Maurizio (ORCID:0000-0001-6699-7980), Posteraro, Brunella (ORCID:0000-0002-1663-7546), Rossi, Elena (ORCID:0000-0002-7572-9379), Santoliquido, Angelo (ORCID:0000-0003-1539-4017), Tamburrini, Enrica (ORCID:0000-0003-4930-426X), Teofili, Luciana (ORCID:0000-0002-7214-1561), Testa, Antonia (ORCID:0000-0003-2217-8726), Trani, Carlo (ORCID:0000-0001-9777-013X), and Verme, Lorenzo Zileri Dal
Abstract: The COVID-19 pandemic is impressively challenging the healthcare system. Several prognostic models have been validated but few of them are implemented in daily practice. The objective of the study was to validate a machine-learning risk prediction model using easy-to-obtain parameters to help to identify patients with COVID-19 who are at higher risk of death. The training cohort included all patients admitted to Fondazione Policlinico Gemelli with COVID-19 from March 5, 2020, to November 5, 2020. Afterward, the model was tested on all patients admitted to the same hospital with COVID-19 from November 6, 2020, to February 5, 2021. The primary outcome was in-hospital case-fatality risk. The out-of-sample performance of the model was estimated from the training set in terms of Area under the Receiving Operator Curve (AUROC) and classification matrix statistics by averaging the results of fivefold cross validation repeated 3-times and comparing the results with those obtained on the test set. An explanation analysis of the model, based on the SHapley Additive exPlanations (SHAP), is also presented. To assess the subsequent time evolution, the change in paO2/FiO2 (P/F) at 48 h after the baseline measurement was plotted against its baseline value. Among the 921 patients included in the training cohort, 120 died (13%). Variables selected for the model were age, platelet count, SpO2, blood urea nitrogen (BUN), hemoglobin, C-reactive protein, neutrophil count, and sodium. The results of the fivefold cross-validation repeated 3-times gave AUROC of 0.87, and statistics of the classification matrix to the Youden index as follows: sensitivity 0.840, specificity 0.774, negative predictive value 0.971. Then, the model was tested on a new population (n=1463) in which the case-fatality rate was 22.6%. The test model showed AUROC 0.818, sensitivity 0.813, specificity 0.650, negative predictive value 0.922. Considering the first quartile of the predicted risk score (low-risk score gro
Published: 2021

92. The rs599839 A>G Variant Disentangles Cardiovascular Risk and Hepatocellular Carcinoma in NAFLD Patients

Author: Meroni, Marica, Longo, Miriam, Paolini, Erika, Alisi, Anna, Miele, Luca, De Caro, Emilia Rita, Pisano, Giuseppina, Maggioni, Marco, Soardo, Giorgio, Valenti, Luca Vittorio, Fracanzani, Anna Ludovica, Dongiovanni, Paola, Miele, Luca (ORCID:0000-0003-3464-0068), Meroni, Marica, Longo, Miriam, Paolini, Erika, Alisi, Anna, Miele, Luca, De Caro, Emilia Rita, Pisano, Giuseppina, Maggioni, Marco, Soardo, Giorgio, Valenti, Luca Vittorio, Fracanzani, Anna Ludovica, Dongiovanni, Paola, and Miele, Luca (ORCID:0000-0003-3464-0068)
Abstract: Simple SummaryDyslipidemia is a hallmark of nonalcoholic fatty liver disease (NAFLD) and the rs599839 variant in the CELSR2-PSRC1-SORT1 genetic cluster, has been associated with a protection against cardiovascular events. Here, we revealed a novel link between the rs599839 variant and hepatocellular carcinoma (HCC) whose onset in the context of NAFLD is rapidly increasing. We found that the rs599839 variant disentangled the risk of HCC from that of cardiovascular abnormalities by modulating SORT1 and PSRC1 expressions. The latter emerged as a potential modifier of liver carcinogenesis.Background and Aims: Dyslipidemia and cardiovascular diseases (CVD) are comorbidities of nonalcoholic fatty liver disease (NAFLD), which ranges from steatosis to hepatocellular carcinoma (HCC). The rs599839 A>G variant, in the CELSR2-PSRC1-SORT1 gene cluster, has been associated CVD, but its impact on metabolic traits and on the severity liver damage in NAFLD has not been investigated yet. Methods: We evaluated the effect of the rs599839 variant in 1426 NAFLD patients (Overall cohort) of whom 131 had HCC (NAFLD-HCC), in 500,000 individuals from the UK Biobank Cohort (UKBBC), and in 366 HCC samples from The Cancer Genome Atlas (TCGA). Hepatic PSRC1, SORT1 and CELSR2 expressions were evaluated by RNAseq (n = 125). Results: The rs599839 variant was associated with reduced circulating LDL, carotid intima-media thickness, carotid plaques and hypertension (p < 0.05) in NAFLD patients and with protection against dyslipidemia in UKBBC. The minor G allele was associated with higher risk of HCC, independently of fibrosis severity (odds ratio (OR): 5.62; 95% c.i. 1.77-17.84, p = 0.003), poor prognosis and advanced tumor stage (p < 0.05) in the overall cohort. Hepatic PSRC1, SORT1 and CELSR2 expressions were increased in NAFLD patients carrying the rs599839 variant (p < 0.0001). SORT1 mRNA levels negatively correlated with circulating lipids and with those of genes involved in lipoprot
Published: 2021

93. An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs

Author: Cordell, Heather J, Fryett, James J, Ueno, Kazuko, Darlay, Rebecca, Aiba, Yoshihiro, Hitomi, Yuki, Kawashima, Minae, Nishida, Nao, Khor, Seik-Soon, Gervais, Olivier, Kawai, Yosuke, Nagasaki, Masao, Tokunaga, Katsushi, Tang, Ruqi, Shi, Yongyong, Li, Zhiqiang, Juran, Brian D, Atkinson, Elizabeth J, Gerussi, Alessio, Carbone, Marco, Asselta, Rosanna, Cheung, Angela, de Andrade, Mariza, Baras, Ari, Horowitz, Julie, Ferreira, Manuel A R, Sun, Dylan, Jones, David E, Flack, Steven, Spicer, Ann, Mulcahy, Victoria L, Byan, Jinyoung, Han, Younghun, Sandford, Richard N, Lazaridis, Konstantinos N, Amos, Christopher I, Hirschfield, Gideon M, Seldin, Michael F, Invernizzi, Pietro, Siminovitch, Katherine A, Ma, Xiong, Nakamura, Minoru, Mells, George F, Miele, Luca, Italian PBC Study, Group, Miele, Luca (ORCID:0000-0003-3464-0068), Cordell, Heather J, Fryett, James J, Ueno, Kazuko, Darlay, Rebecca, Aiba, Yoshihiro, Hitomi, Yuki, Kawashima, Minae, Nishida, Nao, Khor, Seik-Soon, Gervais, Olivier, Kawai, Yosuke, Nagasaki, Masao, Tokunaga, Katsushi, Tang, Ruqi, Shi, Yongyong, Li, Zhiqiang, Juran, Brian D, Atkinson, Elizabeth J, Gerussi, Alessio, Carbone, Marco, Asselta, Rosanna, Cheung, Angela, de Andrade, Mariza, Baras, Ari, Horowitz, Julie, Ferreira, Manuel A R, Sun, Dylan, Jones, David E, Flack, Steven, Spicer, Ann, Mulcahy, Victoria L, Byan, Jinyoung, Han, Younghun, Sandford, Richard N, Lazaridis, Konstantinos N, Amos, Christopher I, Hirschfield, Gideon M, Seldin, Michael F, Invernizzi, Pietro, Siminovitch, Katherine A, Ma, Xiong, Nakamura, Minoru, Mells, George F, Miele, Luca, Italian PBC Study, Group, and Miele, Luca (ORCID:0000-0003-3464-0068)
Abstract: Backgrounds & Aims: Primary biliary cholangitis (PBC) is a chronic liver disease in which autoimmune destruction of the small intrahepatic bile ducts eventually leads to cirrhosis. Many patients have inadequate response to licensed medications, motivating the search for novel therapies. Previous genomewide association studies (GWAS) and meta-analyses (GWMA) of PBC have identified numerous risk loci for this condition, providing insight into its aetiology. We undertook the largest GWMA of PBC to date, aiming to identify additional risk loci and prioritise candidate genes for in silico drug efficacy screening.Methods: We combined new and existing genotype data for 10,516 cases and 20,772 controls from 5 European and 2 East Asian cohorts.Results: We identified 56 genome-wide significant loci (20 novel) including 46 in European, 13 in Asian, and 41 in combined cohorts; and a 57th genome-wide significant locus (also novel) in conditional analysis of the European cohorts. Candidate genes at newly identified loci include FCRL3, INAVA, PRDM1, IRF7, CCR6, CD226, and IL12RB1, which each play key roles in immunity. Pathway analysis reiterated the likely importance of pattern recognition receptor and TNF signalling, JAK-STAT signalling, and differentiation of T helper (TH)1 and TH17 cells in the pathogenesis of this disease. Drug efficacy screening identified several medications predicted to be therapeutic in PBC, some of which are well-established in the treatment of other autoim-mune disorders.Conclusions: This study has identified additional risk loci for PBC, provided a hierarchy of agents that could be trialled in this condition, and emphasised the value of genetic and genomic approaches to drug discovery in complex disorders.Lay summary: Primary biliary cholangitis (PBC) is a chronic liver disease that eventually leads to cirrhosis. In this study, we ana-lysed genetic information from 10,516 people with PBC and 20,772 healthy individuals recruited in Canada, China, It
Published: 2021

94. Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: A systematic review and meta-analysis

Author: Selvaraj, Emmanuel Anandraj, Mózes, Ferenc Emil, Jayaswal, Arjun Narayan Ajmer, Zafarmand, Mohammad Hadi, Vali, Yasaman, Lee, Jenny A, Levick, Christina Kim, Young, Liam Arnold Joseph, Palaniyappan, Naaventhan, Liu, Chang-Hai, Aithal, Guruprasad Padur, Romero-Gómez, Manuel, Brosnan, M Julia, Tuthill, Theresa A, Anstee, Quentin M, Neubauer, Stefan, Harrison, Stephen A, Bossuyt, Patrick M, Pavlides, Michael, Miele, Luca, Litmus, Investigators, Miele, Luca (ORCID:0000-0003-3464-0068), Selvaraj, Emmanuel Anandraj, Mózes, Ferenc Emil, Jayaswal, Arjun Narayan Ajmer, Zafarmand, Mohammad Hadi, Vali, Yasaman, Lee, Jenny A, Levick, Christina Kim, Young, Liam Arnold Joseph, Palaniyappan, Naaventhan, Liu, Chang-Hai, Aithal, Guruprasad Padur, Romero-Gómez, Manuel, Brosnan, M Julia, Tuthill, Theresa A, Anstee, Quentin M, Neubauer, Stefan, Harrison, Stephen A, Bossuyt, Patrick M, Pavlides, Michael, Miele, Luca, Litmus, Investigators, and Miele, Luca (ORCID:0000-0003-3464-0068)
Abstract: Background and Aims: Vibration-controlled transient elastography (VCTE), point shear wave elastography (pSWE), 2 dimensional shear wave elastography (2DSWE), magnetic resonance elastography (MRE), and magnetic resonance imaging (MRI) have been proposed as non-invasive tests for patients with non-alcoholic fatty liver disease (NAFLD). This study evaluated their diagnostic accuracy for liver fibrosis and non-alcoholic steatohepatitis (NASH).Methods: PubMED/MEDLINE, EMBASE and the Cochrane Library were searched for studies examining the diagnostic accuracy of these index tests, against histology as the reference standard, in adult patients with NAFLD. Two authors independently screened and assessed methodological quality of studies and extracted data. Summary estimates of sensitivity, specificity and area under the curve (sAUC) were calculated for fibrosis stages and NASH, using a random effects bivariate logit-normal model.Results: We included 82 studies (14,609 patients). Meta-analysis for diagnosing fibrosis stages was possible in 53 VCTE, 11 MRE, 12 pSWE and 4 2DSWE studies, and for diagnosing NASH in 4 MRE studies. sAUC for diagnosis of significant fibrosis were: 0.83 for VCTE, 0.91 for MRE, 0.86 for pSWE and 0.75 for 2DSWE. sAUC for diagnosis of advanced fibrosis were: 0.85 for VCTE, 0.92 for MRE, 0.89 for pSWE and 0.72 for 2DSWE. sAUC for diagnosis of cirrhosis were: 0.89 for VCTE, 0.90 for MRE, 0.90 for pSWE and 0.88 for 2DSWE. MRE had sAUC of 0.83 for diagnosis of NASH. Three (4%) studies reported intention-to-diagnose analyses and 15 (18%) studies reported diagnostic accuracy against pre specified cut-offs.Conclusions: When elastography index tests are acquired successfully, they have acceptable diagnostic accuracy for advanced fibrosis and cirrhosis. The potential clinical impact of these index tests cannot be assessed fully as intention-to-diagnose analyses and validation of pre-specified thresholds are lacking.Lay summary: Non-invasive tests that measure l
Published: 2021

95. Nonalcoholic fatty liver disease as trigger of cardiovascular and metabolic complication in metabolic syndrome

Author: Miele, Luca, Gasbarrini, Giovanni, Giorgio, Valentina, Gasbarrini, Antonio, and Grieco, Antonio
Published: 2016
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96. Impact of Gut Microbiota on Obesity, Diabetes, and Cardiovascular Disease Risk

Author: Miele, Luca, Giorgio, Valentina, Alberelli, Maria Adele, De Candia, Erica, Gasbarrini, Antonio, and Grieco, Antonio
Published: 2015
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97. Free Light Chains as a potential biomarker of inflammation and fibrosis in non-alcoholic steatohepatitis

Author: Liguori, Antonio, primary, Basile, Umberto, additional, Napodano, Cecilia, additional, Tomasello, Lidia, additional, Mancuso, Fabrizio, additional, Di Gialleonardo, Luca, additional, Marrone, Giuseppe, additional, Biolato, Marco, additional, Gasbarrini, Antonio, additional, Rapaccini, Gian Ludovico, additional, Grieco, Antonio, additional, and Miele, Luca, additional
Published: 2022
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98. Increased burden of inherited IRF3 rare genetic variants in Europeans with severe Non-alcoholic fatty liver diease

Author: Santoro, Luigi, primary, Marchelli, Daniele, additional, Cherubini, Alessandro, additional, Casirati, Elia, additional, Malvestiti, Francesco, additional, Tomasi, Melissa, additional, Dongiovanni, Paola, additional, Bianco, Cristiana, additional, Meroni, Marica, additional, Federico, Alessandro, additional, Petta, Salvatore, additional, Bugianesi, Elisabetta, additional, Soardo, Giorgio, additional, Gentilucci, Umberto Vespasiani, additional, Miele, Luca, additional, Reeves, Helen, additional, Prati, Daniele, additional, Ronzoni, Luisa, additional, Baselli, Giodo, additional, and Valenti, Luca, additional
Published: 2022
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99. Machine Learning-Assisted FTIR Analysis of Circulating Extracellular Vesicles for Cancer Liquid Biopsy

Author: Di Santo, Riccardo, primary, Vaccaro, Maria, additional, Romanò, Sabrina, additional, Di Giacinto, Flavio, additional, Papi, Massimiliano, additional, Rapaccini, Gian Ludovico, additional, De Spirito, Marco, additional, Miele, Luca, additional, Basile, Umberto, additional, and Ciasca, Gabriele, additional
Published: 2022
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100. Global multi-stakeholder endorsement of the MAFLD definition

Author: Méndez-Sánchez, Nahum, primary, Bugianesi, Elisabetta, additional, Gish, Robert G, additional, Lammert, Frank, additional, Tilg, Herbert, additional, Nguyen, Mindie H, additional, Sarin, Shiv K, additional, Fabrellas, Núria, additional, Zelber-Sagi, Shira, additional, Fan, Jian-Gao, additional, Shiha, Gamal, additional, Targher, Giovanni, additional, Zheng, Ming-Hua, additional, Chan, Wah-Kheong, additional, Vinker, Shlomo, additional, Kawaguchi, Takumi, additional, Castera, Laurent, additional, Yilmaz, Yusuf, additional, Korenjak, Marko, additional, Spearman, C Wendy, additional, Ungan, Mehmet, additional, Palmer, Melissa, additional, El-Shabrawi, Mortada, additional, Gruss, Hans-Juergen, additional, Dufour, Jean-François, additional, Dhawan, Anil, additional, Wedemeyer, Heiner, additional, George, Jacob, additional, Valenti, Luca, additional, Fouad, Yasser, additional, Romero‐Gomez, Manuel, additional, Eslam, Mohammed, additional, Abate, Maria Lorena, additional, Abbas, Bahaa, additional, Abbassy, Ahmed Amr, additional, Abd El Ghany, Waleed, additional, Abd Elkhalek, Amira, additional, Abd ElMajeed, Emad, additional, Abdalgaber, Mohammad, additional, AbdAllah, Mohamed, additional, Abdallah, Marwa, additional, Abdallah, Nourhan, additional, Abdelaleem, Shereen, additional, Abdelghani, Yasser, additional, Abdelghany, Wael, additional, Abdelhalim, Safaa Mohamed, additional, Abdelhamid, Wafaa, additional, Abdelhamid, Nehal, additional, Abdelkader, Nadia A., additional, Abdelkreem, Elsayed, additional, Abdelmohsen, Aly Mohamed, additional, Abdelrahman, Awny Ali, additional, Abd-elsalam, Sherief M, additional, Abdeltawab, Doaa, additional, Abduh, Abdulbaset, additional, Abdulhakam, Nada, additional, Abdulla, Maheeba, additional, Abedpoor, Navid, additional, Abenavoli, Ludovico, additional, Åberg, Fredrik, additional, Ablack, Omala, additional, Abo elftouh, Mostafa, additional, Abo-Amer, Yousry Esam-Eldin, additional, Aboubkr, Ashraf, additional, Aboud, Alaa, additional, Abouelnaga, Amr M., additional, Aboufarrag, Galal A., additional, Aboutaleb, Ashraf, additional, Abundis, Leticia, additional, Adalı, Gupse, additional, Adames, Enrique, additional, Adams, Leon, additional, Adda, Danjuma, additional, Adel, Noor, additional, Adel, Nada, additional, Adel Sayed, Muhammad, additional, Afaa, Taiba Jibril, additional, Afredj, Nawal, additional, Aghayeva, Gulnara, additional, Aghemo, Alessio, additional, Aguilar-Salinas, Carlos A., additional, Ahlenstiel, Golo, additional, Ahmady, Walid, additional, Ahmed, Wafaa, additional, Ahmed, Amira, additional, Ahmed, Samah Nasser, additional, Ahmed, Heba Mostafa, additional, Ahmed, Rasha, additional, Aigner, Elmar, additional, Akarsu, Mesut, additional, Akroush, Maisam, additional, Akyuz, Umit, additional, Al Mahtab, Mamun, additional, Al Qadiri, Tahani, additional, Al Rawahi, Yusriya, additional, AL rubaee, Razzaq, additional, Al Saffar, Muna, additional, Alam, Shahinul, additional, Al-Ani, Zaid, additional, Albillos, Agustín, additional, Alboraie, Mohamed, additional, Al-Busafi, Said, additional, Al-Emam, Mohamed, additional, Alharthi, Jawaher, additional, Ali, Kareem, additional, Ali, Basma Abdelmoez, additional, Ali, Mohammad, additional, Ali, Raja Affendi Raja, additional, Alisi, Anna, additional, AL-Khafaji, Ali Raad, additional, Alkhatry, Maryam, additional, Aller, Rocio, additional, Almansoury, Yahya, additional, Al-Naamani, Khalid, additional, Alnakeeb, Alaa, additional, Alonso, Anna, additional, Alqahtani, Saleh A., additional, Alrabadi, Leina, additional, Alswat, Khalid, additional, Altaher, Mahir, additional, Altamimi, Turki, additional, Altamirano, Jose, additional, Alvares-da-Silva, Mario R., additional, Aly, Elsragy Adel M., additional, Alzahaby, Amgad, additional, Alzamzamy, Ahmed, additional, Amano, Keisuke, additional, Amer, Maysa A., additional, Amin, Mona A., additional, Amin, Sayed A., additional, Amir, Ashraf A., additional, Ampuero, Javier, additional, Anas, Noha, additional, Andreone, Pietro, additional, Andriamandimby, Soa Fy, additional, Anees, Mahmoud, additional, Angela, Peltec, additional, Antonios, Manal, additional, Arafat, Wael, additional, Araya, Jose Moreno, additional, Armendariz-Borunda, Juan, additional, Armstrong, Matthew J., additional, Ashktorab, Hassan, additional, Aspichueta, Patricia, additional, Assal, Fathia, additional, Atef, Mira, additional, Attia, Dina, additional, Atwa, Hoda, additional, Awad, Reham, additional, Awad, Mohyeldeen Abd Elaziz, additional, Awny, Sally, additional, Awolowo, Obafemi, additional, Awuku, Yaw Asante, additional, Ayada, Ibrahim, additional, Aye, Than Than, additional, Ayman, Sherif, additional, Ayman, Hedy, additional, Ayoub, Hesham, additional, Azmy, Hosny M., additional, Babaran, Romiro P., additional, Badreldin, Omneya, additional, Badry, Ahmed, additional, Bahçecioğlu, İbrahim Halil, additional, Bahour, Amira, additional, Bai, Jiajia, additional, Balaban, Yasemin, additional, Balasubramanyam, Muthuswamy, additional, Bamakhrama, Khaled, additional, Banales, Jesus M, additional, Bangaru, Babu, additional, Bao, Jianfeng, additional, Barahona, Jorge Suazo, additional, Barakat, Salma, additional, Barbalho, Sandra Maria, additional, Barbra, Bikwa, additional, Barranco, Beatriz, additional, Barrera, Francisco, additional, Baumann, Ulrich, additional, Bazeed, Shamardan, additional, Bech, Eva, additional, Benayad, Aourarh, additional, Benesic, Andreas, additional, Bernstein, David, additional, Bessone, Fernando, additional, Birney, Susie, additional, Bisseye, Cyrille, additional, Blake, Martin, additional, Bobat, Bilal, additional, Bonfrate, Leonilde, additional, Bordin, Dmitry S, additional, Bosques-Padilla, Francisco, additional, Boursier, Jerome, additional, Boushab, Boushab Mohamed, additional, Bowen, David, additional, Bravo, Patricia Medina, additional, Brennan, Paul N, additional, Bright, Bisi, additional, Broekaert, Ilse, additional, Buque, Xabier, additional, Burgos-Santamaría, Diego, additional, Burman, Julio, additional, Busetto, Luca, additional, Byrne, Chris D., additional, Cabral-Prodigalidad, Patricia Anne I., additional, Cabrera-Alvarez, Guillermo, additional, Cai, Wei, additional, Cainelli, Francesca, additional, Caliskan, Ali Riza, additional, Canbay, Ali, additional, Cano-Contreras, Ana, additional, Cao, Hai-Xia, additional, Cao, Zhujun, additional, Carrion, Andres, additional, Carubbi, Francesca, additional, Casanovas, Teresa, additional, Castellanos Fernández, Marlen Ivón, additional, Chai, Jin, additional, Chan, Siew Pheng, additional, Charatcharoenwitthaya, Phunchai, additional, Chavez-Tapia, Norberto, additional, Chayama, Kazuaki, additional, Chen, Jinjun, additional, Chen, Lin, additional, Chen, Zhong-Wei, additional, Chen, Huiting, additional, Chen, Sui-Dan, additional, Chen, Qiang, additional, Chen, Yaxi, additional, Chen, Gang, additional, Chen, En-Quang, additional, Chen, Fei, additional, Chen, Pei-Jer, additional, Cheng, Robert, additional, Cheng, Wendy, additional, Chieh, Jack Tan Wei, additional, Chokr, Imad, additional, Cholongitas, Evangelos, additional, Choudhury, Ashok, additional, Chowdhury, Abhijit, additional, Chukwudike, Evaristus Sunday, additional, Ciardullo, Stefano, additional, Clayton, Michelle, additional, Clement, Karine, additional, Cloa, Marie Michelle, additional, Coccia, Cecilia, additional, Collazos, Cristina, additional, Colombo, Massimo, additional, Cosar, Arif Mansur, additional, Cotrim, Helma Pinchemel, additional, Couillerot, Joris, additional, Coulibaly, Alioune, additional, Crespo, Gonzalo, additional, Crespo, Javier, additional, Cruells, Maria, additional, Cua, Ian Homer Y., additional, Dabbous, Hesham K., additional, Dalekos, George N, additional, D'Alia, Patricia, additional, Dan, Li, additional, Dao, Viet Hang, additional, Darwish, Mostafa, additional, Datz, Christian, additional, Davalos-Moscol, Milagros B, additional, Dawoud, Heba, additional, de Careaga, Blanca Olaechea, additional, de Knegt, Robert, additional, de Ledinghen, Victor, additional, de Silva, Janaka, additional, Debzi, Nabil, additional, Decraecker, Marie, additional, Del Pozo, Elvira, additional, Delgado, Teresa C, additional, Delgado-Blanco, Manuel, additional, Dembiński, Łukasz, additional, Depina, Adilson, additional, Derbala, Moutaz, additional, Desalegn, Hailemichael, additional, Desbois-Mouthon, Christèle, additional, Desoky, Mahmoud, additional, Dev, Anouk, additional, Di Ciaula, Agostino, additional, Diago, Moisés, additional, Diallo, Ibrahima, additional, Díaz, Luis Antonio, additional, Dirchwolf, Melisa, additional, Dongiovanni, Paola, additional, Dorofeyev, Andrriy, additional, Dou, Xiaoguang, additional, Douglas, Mark W., additional, Doulberis, Michael, additional, Dovia, Cecil K., additional, Doyle, Adam, additional, Dragojević, Ivana, additional, Drenth, Joost PH, additional, Duan, Xuefei, additional, Dulskas, Audrius, additional, Dumitrascu, Dan L, additional, Duncan, Oliver, additional, Dusabejambo, Vincent, additional, Dwawhi, Rev. Shem N.A., additional, Eiketsu, Sho, additional, El Amrousy, Doaa, additional, El Deeb, Ahmed, additional, El Deriny, Ghada, additional, El Din, Hesham Salah, additional, El Kamshishy, Salwa, additional, El Kassas, Mohamed, additional, El Raziky, Maissa, additional, Elagamy, Osama A, additional, Elakel, Wafaa, additional, Elalfy, Dina, additional, Elaraby, Hanaa, additional, ElAwady, Heba, additional, Elbadawy, Reda, additional, Eldash, Hanaa Hassan, additional, Eldefrawy, Manal S., additional, Elecharri, Carol Lezama, additional, Elfaramawy, Amel, additional, Elfatih, Mohammed, additional, Elfiky, Mahmoud, additional, Elgamsy, Mohamed, additional, Elgendy, Mohamed, additional, El-Guindi, Mohamed A., additional, Elhussieny, Nagi, additional, Eliwa, Ahmed Maher, additional, Elkabbany, Zeineb, additional, El-Khayat, Hesham, additional, El-Koofy, Nehal M., additional, Elmetwalli, Alaa, additional, Elrabat, Amr, additional, El-Raey, Fathiya, additional, Elrashdy, Fatma, additional, Elsahhar, Medhat, additional, Elsaid, Esraa M., additional, Elsayed, Shimaa, additional, Elsayed, Hany, additional, Elsayed, Aly, additional, Elsayed, Amr M., additional, Elsayed, Hamdy, additional, El-Serafy, Magdy, additional, Elsharkawy, Ahmed M., additional, Elsheemy, Reem Yehia, additional, Elshemy, Eman Elsayed, additional, Elsherbini, Sara, additional, Eltoukhy, Naglaa, additional, Elwakil, Reda, additional, Emad, Ola, additional, Emad, Shaimaa, additional, Embabi, Mohamed, additional, Ergenç, Ilkay, additional, Ermolova, Tatiana, additional, Esmat, Gamal, additional, Esmat, Doaa M., additional, Estupiñan, Enrique Carrera, additional, Ettair, Said, additional, Eugen, Tcaciuc, additional, Ezz-Eldin, Mohammed, additional, Falcón, Lidia Patricia Valdivieso, additional, Fan, Yu-Chen, additional, Fandari, Samah, additional, Farag, Mahmoud, additional, Farahat, Taghreed Mohamed, additional, Fares, Eman M., additional, Fares, Michael, additional, Fassio, Eduardo, additional, Fathy, Hayam, additional, Fathy, Dina, additional, Fathy, Wael, additional, Fayed, Soheir, additional, Feng, Dan, additional, Feng, Gong, additional, Fernández-Bermejo, Miguel, additional, Ferreira, Cristina Targa, additional, Ferrer, Javier Díaz, additional, Forbes, Alastair, additional, Fouad, Rabab, additional, Fouad, Hanan M., additional, Frisch, Tove, additional, Fujii, Hideki, additional, Fukunaga, Shuhei, additional, Fukunishi, Shinya, additional, Fulya, Hacer, additional, Furuhashi, Masato, additional, Gaber, Yasmine, additional, Galang, Augusto Jose G., additional, Gallardo, Jacqueline Cordova, additional, Galloso, Rocío, additional, Gamal, Mahmoud, additional, Gamal, Reham, additional, Gamal, Hadeel, additional, Gan, Jian, additional, Ganbold, Anar, additional, Gao, Xin, additional, Garas, George, additional, Garba, Tony, additional, García-Cortes, Miren, additional, García-Monzón, Carmelo, additional, García-Samaniego, Javier, additional, Gastaldelli, Amalia, additional, Gatica, Manuel, additional, Gatley, Elizabeth, additional, Gegeshidze, Tamar, additional, Geng, Bin, additional, Ghazinyan, Hasmik, additional, Ghoneem, Salma, additional, Giacomelli, Luca, additional, Giannelli, Gianluigi, additional, Giannini, Edoardo G., additional, Giefer, Matthew, additional, Ginès, Pere, additional, Girala, Marcos, additional, Giraudi, Pablo J, additional, Goh, George Boon-Bee, additional, Gomaa, Ahmed Ali, additional, Gong, Benbingdi, additional, Gonzales, Dina Hilda C., additional, Gonzalez, Humberto C., additional, Gonzalez-Huezo, Maria Saraí, additional, Graupera, Isabel, additional, Grgurevic, Ivica, additional, Grønbæk, Henning, additional, Gu, Xuelian, additional, Guan, Lin, additional, Gueye, Ibrahima, additional, Guingané, Alice Nanelin, additional, Gul, Ozen Oz, additional, Gul, Cuma Bulent, additional, Guo, Qing, additional, Gupta, Pramendra Prasad, additional, Gurakar, Ahmet, additional, Gutierrez, Juan Carlos Restrepo, additional, Habib, Ghada, additional, Hafez, Azaa, additional, Hagman, Emilia, additional, Halawa, Eman, additional, Hamdy, Osama, additional, Hamed, Abd Elkhalek, additional, Hamed, Dina H., additional, Hamid, Saeed, additional, Hamoudi, Waseem, additional, Han, Yu, additional, Haridy, James, additional, Haridy, Hanan, additional, Harris, David C H Harris, additional, Hart, Michael, additional, Hasan, Fuad, additional, Hashim, Almoutaz, additional, Hassan, Israa, additional, Hassan, Ayman, additional, Hassan, Essam Ali, additional, Hassan, Adel Ahmed, additional, Hassan, Magda Shehata, additional, Hassanin, Fetouh, additional, Hassnine, Alshymaa, additional, Haukeland, John Willy, additional, Hawal, Amr Ismael M., additional, He, Jinfan, additional, He, Qiong, additional, He, Yong, additional, He, Fang-Ping, additional, Hegazy, Mona, additional, Hegazy, Adham, additional, Henegil, Osama, additional, Hernández, Nelia, additional, Hernández-Guerra, Manuel, additional, Higuera-de-la-Tijera, Fatima, additional, Hindy, Ibrahim, additional, Hirota, Keisuke, additional, Ho, Lee Chi, additional, Hodge, Alexander, additional, Hosny, Mohamed, additional, Hou, Xin, additional, Huang, Jiao-Feng, additional, Huang, Yan, additional, Huang, Zhifeng, additional, Huang, Yuan, additional, Huang, Ang, additional, Huang, Xiao-Ping, additional, Hui-ping, Sheng, additional, Hunyady, Bela, additional, Hussein, Mennatallah A., additional, Hussein, Osama, additional, Hussien, Shahinaz Mahmoud, additional, Ibáñez-Samaniego, Luis, additional, Ibdah, Jamal, additional, Ibrahim, Luqman, additional, Ibrahim, Miada, additional, Ibrahim, Ibrahim, additional, Icaza-Chávez, Maria E., additional, Idelbi, Sahar, additional, Idilman, Ramazan Idilman, additional, Ikeda, Mayumi, additional, Indolfi, Giuseppe, additional, Invernizzi, Federica, additional, Irshad, Iram, additional, Isa, Hasan Mohamed Ali, additional, Iskandar, Natacha Jreige, additional, Ismaiel, Abdulrahman, additional, Ismail, Mariam, additional, Ismail, Zulkifli, additional, Ismail, Faisal, additional, Iwamoto, Hideki, additional, Jack, Kathryn, additional, Jacob, Rachael, additional, Jafarov, Fuad, additional, Jafri, Wasim, additional, Jahshan, Helen, additional, Jalal, Prasun K, additional, Jancoriene, Ligita, additional, Janicko, Martin, additional, Jayasena, Hiruni, additional, Jefferies, Meryem, additional, Jha, Vivekanand, additional, Ji, Fanpu, additional, Ji, Yaqiu, additional, Jia, Jidong, additional, Jiang, Changtao, additional, Jiang, Ni, additional, Jiang, Zong-zhe, additional, Jin, Xing, additional, Jin, Yi, additional, Jing, Xu, additional, Jingyu, Qian, additional, Jinjolava, Maia, additional, Jong, FX Himawan Haryanto, additional, Jucov, Alina, additional, Julius, Ibecheole, additional, Kaddah, Mona, additional, Kamada, Yoshihiro, additional, kamal, Abobakr, additional, Kamal, Enas Mohamed, additional, Kamel, Ashraf Sayed, additional, Kao, Jia-Horng, additional, Karin, Maja, additional, Karlas, Thomas, additional, Kashwaa, Mohammad, additional, Katsidzira, Leolin, additional, Kaya, Eda, additional, Kayasseh, M.Azzam, additional, Keenan, Bernadette, additional, Keklikkiran, Caglayan, additional, Keml, William, additional, Khalaf, Deia K., additional, Khalefa, Rofida, additional, Khamis, Sherin, additional, Khater, Doaa, additional, khattab, Hamed, additional, Khavkin, Anatoly, additional, Khlynova, Olga, additional, Khmis, Nabil, additional, Kobyliak, Nazarii, additional, Koffas, Apostolos, additional, Koike, Kazuhiko, additional, Kok, Kenneth Y.Y., additional, Koller, Tomas, additional, Komas, Narcisse Patrice, additional, Korochanskaya, Nataliya V., additional, Koulla, Yannoula, additional, Koya, Shunji, additional, Kraft, Colleen, additional, Kraja, Bledar, additional, Krawczyk, Marcin, additional, Kuchay, Mohammad Shafi, additional, Kulkarni, Anand V, additional, Kumar, Ashish, additional, Kumar, Manoj, additional, Lakoh, Sulaiman, additional, Lam, Philip, additional, Lan, Ling, additional, Lange, Naomi F., additional, Lankarani, Kamran Bagheri, additional, Lanthier, Nicolas, additional, Lapshyna, Kateryna, additional, Lashen, Sameh A., additional, Laure, Konang Nguieguia Justine, additional, Lazebnik, Leonid, additional, Lebrec, Didier, additional, Lee, Samuel S., additional, Lee, Way Seah, additional, Lee, Yeong Yeh, additional, Leeming, Diana Julie, additional, Leite, Nathalie Carvalho, additional, Leon, Roberto, additional, Lesmana, Cosmas Rinaldi Adithya, additional, Li, Junfeng, additional, Li, Qiong, additional, Li, Jun, additional, Li, Yang-Yang, additional, Li, Yufang, additional, Li, Lei, additional, Li, Min, additional, li, Yiling, additional, Liang, Huiqing, additional, Lijuan, Tang, additional, Lim, Seng Gee, additional, Lim, Lee-Ling, additional, Lin, Shumei, additional, Lin, Han-Chieh, additional, Lin, Rita, additional, Lithy, Rania, additional, Liu, Yaru, additional, Liu, Yuanyuan, additional, Liu, Xin, additional, Liu, Wen-Yue, additional, Liu, Shourong, additional, Liu, Ken, additional, Liu, Tian, additional, Lonardo, Amedeo, additional, López, Mariana Bravo, additional, López-Benages, Eva, additional, Lopez-Jaramillo, Patricio, additional, Lu, Huimin, additional, Lu, Lun Gen, additional, Lu, Yan, additional, Lubel, John, additional, Lui, Rashid, additional, Lupasco, Iulianna, additional, Luzina, Elena, additional, Lv, Xiao-Hui, additional, Lynch, Kate, additional, Ma, Hong-Lei, additional, Machado, Mariana Verdelho, additional, Maduka, Nonso, additional, Madzharova, Katerina, additional, Magdaong, Russellini, additional, Mahadeva, Sanjiv, additional, Mahfouz, Amel, additional, Mahmood, Nik Ritza Kosai Nik, additional, Mahmoud, Eman, additional, Mahrous, Mohamed, additional, Maiwall, Rakhi, additional, Majeed, Ammar, additional, Majumdar, Avik, additional, Mak, Loey, additional, Maklouf, Madiha M, additional, Malekzadeh, Reza, additional, Mandato, Claudia, additional, Mangia, Alessandra, additional, Mann, Jake, additional, Mansour, Hala Hussien, additional, Mansouri, Abdellah, additional, Mantovani, Alessandro, additional, Mao, Jun qian, additional, Maramag, Flor, additional, Marchesini, Giulio, additional, Marcus, Claude, additional, Marinho, Rui António Rocha Tato, additional, Martinez-Chantar, Maria L, additional, Martins, Antonieta A. Soares, additional, Marwan, Rana, additional, Mason, Karen Frances, additional, Masoud, Ghadeer, additional, Massoud, Mohamed Naguib, additional, Matamoros, Maria Amalia, additional, Mateos, Rosa Martín, additional, Mawed, Asmaa, additional, Mbanya, Jean Claude, additional, Mbendi, Charles, additional, McColaugh, Lone, additional, McLeod, Duncan, additional, Medina, Juan Francisco Rivera, additional, Megahed, Ahmed, additional, Mehrez, Mai, additional, Memon, Iqbal, additional, Merat, Shahin, additional, Mercado, Randy, additional, Mesbah, Ahmed, additional, Meskini, Taoufik, additional, Metwally, Mayada, additional, Metwaly, Rasha, additional, Miao, Lei, additional, Micah, Eileen, additional, Miele, Luca, additional, Milivojevic, Vladimir, additional, Milovanovic, Tamara, additional, Mina, Yvonne L., additional, Mishkovik, Milan, additional, Mishriki, Amal, additional, Mitchell, Tim, additional, Mohamed, Alshaimaa, additional, Mohamed, Mona, additional, Mohamed, Sofain, additional, Mohammed, Shady, additional, Mohammed, Ahmed, additional, Mohan, Viswanathan, additional, Mohie, Sara, additional, Mokhtar, Aalaa, additional, Moniem, Reham, additional, Montilla, Mabel Segura, additional, Morales, Jose Antonio Orozco, additional, Morata, María María Sánchez, additional, Moreno-Planas, Jose Maria, additional, Morise, Silvia, additional, Mosaad, Sherif, additional, Moselhy, Mohamed, additional, Mostafa, Alaa Mohamed, additional, Mostafa, Ebraheem, additional, Mouane, Nezha, additional, Mousa, Nasser, additional, Moustafa, Hamdy Mahfouz, additional, Msherif, Abeer, additional, Muller, Kate, additional, Munoz, Christopher, additional, Muñoz-Urribarri, Ana Beatriz, additional, Murillo, Omar Alfaro, additional, Mustapha, Feisul Idzwan, additional, Muzurović, Emir, additional, Nabil, Yehia, additional, Nafady, Shaymaa, additional, Nagamatsu, Ayu, additional, Nakajima, Atsushi, additional, Nakano, Dan, additional, Nan, Yuemin, additional, Nascimbeni, Fabio, additional, Naseef, Mirella S., additional, Nashat, Nagwa, additional, Natalia, Taran, additional, Negro, Francesco, additional, Nersesov, Alexander V., additional, Neuman, Manuela, additional, Ng'wanasayi, Masolwa, additional, Ni, Yan, additional, Nicoll, Amanda, additional, Niizeki, Takashi, additional, Nikolova, Dafina, additional, Ningning, Wang, additional, Niriella, Madunil, additional, Nogoibaeva, K.A, additional, Nordien, Rozeena, additional, O Sullivan, Catherine, additional, O'Beirne, James, additional, Obekpa, Solomon, additional, Ocama, Ponsiano, additional, Ochwoto, Missiani, additional, Ogolodom, Michael Promise, additional, Ojo, Olusegun, additional, Okrostsvaridze, Nana, additional, Oliveira, Claudia P., additional, Omaña, Raul Contreras, additional, Omar, Omneya M., additional, Omar, Hanaa, additional, Omar, Mabroka, additional, Omran, Salma, additional, Omran, Reham, additional, Osman, Marian Muse, additional, Owise, Nevin, additional, Owusu-Ansah, Theobald, additional, Padilla- Machaca, P. Martín, additional, Palle, Sirish, additional, Pan, Ziyan, additional, Pan, Xiao-Yan, additional, Pan, Qiuwei, additional, Papaefthymiou, Apostolis, additional, Paquissi, Feliciano Chanana, additional, Par, Gabriella, additional, Parkash, Arit, additional, Payawal, Diana, additional, Peltekian, Kevork M., additional, Peng, Xuebin, additional, Peng, Liang, additional, Peng, Ying, additional, Pengoria, Rahul, additional, Perez, Martina, additional, Pérez, José Luis, additional, Pérez, Norma Marlene, additional, Persico, Marcello, additional, Pessoa, Mário Guimarães, additional, Petta, Salvatore, additional, Philip, Mathew, additional, Plaz Torres, Maria Corina, additional, Polavarapu, Naveen, additional, Poniachik, Jaime, additional, Portincasa, Piero, additional, Pu, Chunwen, additional, Pürnak, Tuğrul, additional, Purwanto, Edhie, additional, Qi, Xiaolong, additional, Qi, Xingshun, additional, Qian, Zibing, additional, Qiang, Zhao, additional, Qiao, Zengpei, additional, Qiao, Liang, additional, Queiroz, Alberto, additional, Rabiee, Atoosa, additional, Radwan, Manal, additional, Rahetilahy, Alain Marcel, additional, Ramadan, Yasmin, additional, Ramadan, Dina, additional, Ramli, Anis Safura, additional, Ramm, Grant A., additional, Ran, Ao, additional, Rankovic, Ivan, additional, RAO, Huiying, additional, Raouf, Sara, additional, Ray, Sayantan, additional, Reau, Nancy, additional, Refaat, Ahmed, additional, Reiberger, Thomas, additional, Remes-Troche, Jose M, additional, Reyes, Eira Cerda, additional, Richardson, Ben, additional, Ridruejo, Ezequiel, additional, Riestra Jimenez, Sergio, additional, Rizk, Ibrahim, additional, Roberts, Stuart, additional, Roblero, Juan Pablo, additional, Robles, Jorge Alberto Prado, additional, Rockey, Don, additional, Rodríguez, Manuel, additional, Rodríguez Hernández, Heriberto, additional, Román, Eva, additional, Romeiro, Fernando Gomes, additional, Romeo, Stefano, additional, Rosales-Zabal, Jose Miguel, additional, Roshdi, Georgina R., additional, Rosso, Natalia, additional, Ruf, Andres, additional, Ruiz, Patricia Cordero, additional, Runes, Nelia R., additional, Ruzzenente, Andrea, additional, Ryan, Marno, additional, Saad, Ahmed, additional, Sabbagh, Eman BE, additional, Sabbah, Meriam, additional, Saber, Shimaa, additional, Sabrey, Reham, additional, Sabry, Ramy, additional, Saeed, Maysaa Abdallah, additional, Said, Dina, additional, Said, Ebada M, additional, Sakr, Mohammad Amin, additional, Salah, Yara, additional, Salama, Rabab Maamoun, additional, Salama, Asmaa, additional, Saleh, Hussein, additional, Saleh, Ahmed, additional, Salem, Ahmed, additional, Salem, Ahmed Thabet, additional, Salifou, Alkassoum, additional, Salih, Aso Faeq, additional, Salman, Abdallah, additional, Samouda, Hanen, additional, Sanai, Faisal, additional, Sánchez-Ávila, Juan Francisco, additional, Sanker, Lakshumanan, additional, Sano, Tomoya, additional, Sanz, Miquel, additional, Saparbu, Tobokalova, additional, Sawhney, Rohit, additional, Sayed, Fatma, additional, Sayed, Sayed A., additional, Sayed, Ashraf Othman, additional, Sayed, Manar, additional, Sebastiani, Giada, additional, Secadas, Laura, additional, Sediqi, Khawaja Qamaruddin, additional, Seif, Sameh, additional, Semida, Nady, additional, Şenateş, Ebubekir, additional, Serban, Elena Daniela, additional, Serfaty, Lawrence, additional, Seto, Wai-Kay, additional, Sghaier, Ikram, additional, Sha, Min, additional, Shabaan, Hamada M., additional, Shalaby, Lobna, additional, Shaltout, Inass, additional, Sharara, Ala I., additional, Sharma, Vishal, additional, Shawa, Isaac Thom, additional, Shawkat, Ahmed, additional, Shawky, Nehal, additional, Shehata, Osama, additional, Sheils, Sinead, additional, Shewaye, Abate Bane, additional, Shi, Guojun, additional, Shi, Junping, additional, Shimose, Shigeo, additional, Shirono, Tomotake, additional, Shou, Lan, additional, Shrestha, Ananta, additional, Shui, Guanghou, additional, Sievert, William, additional, Sigurdardottir, Solveig, additional, Sira, Mostafa Mohamed, additional, Siradj, Riyadh, additional, Sison, Cecilia, additional, Smyth, Linda, additional, Soliman, Reham, additional, Sollano, Jose D, additional, Sombie, Roger, additional, Sonderup, Mark, additional, Sood, Siddharth, additional, Soriano, German, additional, Stedman, Catherine A M, additional, Stefanyuk, Oksana, additional, Štimac, Davor, additional, Strasser, Simone, additional, Strnad, Pavel, additional, Stuart, Katherine, additional, Su, Wen, additional, Su, Minghua, additional, Sumida, Yoshio, additional, Sumie, Shuji, additional, Sun, Dan-Qin, additional, Sun, Jing, additional, Suzuki, Hiroyuki, additional, Svegliati-Baroni, Gianluca, additional, Swar, Mohamed Osman, additional, TAHARBOUCHT, S., additional, Taher, Zenab, additional, Takamura, Saori, additional, Tan, Lin, additional, Tan, Soek-Siam, additional, Tanwandee, Tawesak, additional, Tarek, Sara, additional, Tatiana, Ghelimici, additional, Tavaglione, Federica, additional, Tecson, Gina Y., additional, Tee, Hoi-Poh, additional, Teschke, Rolf, additional, Tharwat, Mostafa, additional, Thong, Vo Duy, additional, Thursz, Mark, additional, Tine, Tulari, additional, Tiribelli, Claudio, additional, Tolmane, Ieva, additional, Tong, Jing, additional, Tongo, Marco, additional, Torkie, Mamdouh, additional, Torre, Aldo, additional, Torres, Esther A, additional, Trajkovska, Meri, additional, Treeprasertsuk, Sombat, additional, Tsutsumi, Tsubasa, additional, Tu, Thomas, additional, Tur, Josep A., additional, Turan, Dilara, additional, Turcan, Svetlana, additional, Turkina, Svetlana, additional, Tutar, Engin, additional, Tzeuton, Christian, additional, Ugiagbe, Rose, additional, Uygun, Ahmet, additional, Vacca, Michele, additional, Vajro, Pietro, additional, Van der Poorten, David, additional, Van Kleef, Laurens A., additional, Vashakidze, Eliza, additional, Velazquez, Carlos Moctezuma, additional, Velazquez, Mirtha Infante, additional, Vento, Sandro, additional, Verhoeven, Veronique, additional, Vespasiani-Gentilucci, Umberto, additional, Vethakkan, Shireene Ratna, additional, Vilaseca, Josep, additional, Vítek, Libor, additional, Volkanovska, Ance, additional, Wallace, Michael, additional, Wan, Wang, additional, Wang, Yan, additional, Wang, Ying, additional, Wang, Xiaolin, additional, Wang, Xuemei, additional, Wang, Chengyan, additional, Wang, Chunjiong, additional, Wang, Mingjie, additional, Wangchuk, Pelden, additional, Weltman, Martin, additional, White, MaryFrances, additional, Wiegand, Johannes, additional, Wifi, Mohamed-Naguib, additional, Wigg, Alan, additional, Wilhelmi, Markus, additional, William, Remon, additional, Wittenburg, Henning, additional, Wu, Shengjie, additional, Wubeneh, Abdu Mohammed, additional, Xia, Hongping, additional, Xiao, Jian, additional, Xiao, Xiao, additional, Xiaofeng, Wang, additional, Xiong, Wanyuan, additional, Xu, Liang, additional, Xu, Jie, additional, Xu, Weiguo, additional, Xu, Jing-Hang, additional, Xu, Keshu, additional, Xu, Yumin, additional, Xu, Shi-Hao, additional, Xu, Meng, additional, Xu, Aimin, additional, Xu, Chengfu, additional, Yan, Hongmei, additional, Yang, Jingyi, additional, Yang, Rui-Xu, additional, Yang, Yating, additional, Yang, Qinhe, additional, Yang, Naibin, additional, Yao, Jia, additional, Yara, Justine, additional, Yaraş, Serkan, additional, Yılmaz, Nimet, additional, Younes, Ramy, additional, younes, Huda, additional, Young, Sona, additional, Youssef, Farah, additional, Yu, Yanyan, additional, Yu, Ming-Lung, additional, Yuan, Jing, additional, Yue, Zhang, additional, Yuen, Man-Fung, additional, Yun, Wang, additional, Yurukova, Nonka, additional, Zakaria, Serag, additional, Zaky, Samy, additional, Zaldastanishvili, Maia, additional, Zapata, Rodrigo, additional, Zare, Nazanin, additional, Zerem, Enver, additional, Zeriban, Nema, additional, Zeshuai, Xu, additional, Zhang, Huijie, additional, Zhang, Xuemei, additional, Zhang, Yupei, additional, Zhang, Wen-Hua, additional, Zhang, Xuchen, additional, Zhang, Yon-ping, additional, Zhang, Yuexin, additional, Zhang, Zhan-qing, additional, Zhao, Jingmin, additional, Zhao, Rong-Rong, additional, Zhao, Hongwei, additional, Zheng, Chao, additional, Zheng, Yijie, additional, Zheng, Ruidan, additional, Zheng, Tian-Lei, additional, Zheng, Kenneth, additional, Zhou, Xi Qiao, additional, Zhou, Yongjian, additional, Zhou, Yu-Jie, additional, Zhou, Hong, additional, Zhou, Ling, additional, Zhou, Yongning, additional, Zhu, Long dong, additional, Zhu, Yong Fen, additional, Zhu, Yueyong, additional, Zhu, Pei-Wu, additional, Ziada, Ebtesam, additional, Ziring, David, additional, Ziyi, Li, additional, Zou, Shanshan, additional, Zou, Zhengsheng, additional, Zou, Huaibin, additional, and Zuart Ruiz, Roberto, additional
Published: 2022
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