180 results on '"Meiqi Zhang"'
Search Results
52. [Retracted] MicroRNA‑122 affects cell aggressiveness and apoptosis by targeting PKM2 in human hepatocellular carcinoma
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Qiuran Xu, Meiqi Zhang, Jianfeng Tu, Linxiao Pang, Wenwei Cai, and Xin Liu
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Cancer Research ,Oncology ,General Medicine - Published
- 2023
53. Selective Attention Switching Costs for Different Types of Online Game Players in Category Learning
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Meiqi Zhang and qiang xing
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- 2023
54. Study on the Flow and Determinants of Foreign Direct Investment in Guangdong Province - Based on Fixed effects Panel Model
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Xiling Wu, Meiqi Zhang, and Man Xie
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- 2023
55. Decadal variation of thermocline-sea surface temperature feedback in the tropical Indian Ocean and the underlying mechanisms
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Lin Feng, Shuangwen Sun, Lin Liu, Meiqi Zhang, and Yongcan Zu
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Sea surface temperature ,Oceanography ,Global warming ,Rossby wave ,Ekman transport ,Upwelling ,Aquatic Science ,Hiatus ,Variation (astronomy) ,Thermocline ,Geology - Abstract
The thermocline-sea surface temperature (SST) feedback is the most important component of the Bjerknes feedback, which plays an important role in the development of the air-sea coupling modes of the Indian Ocean. The thermocline-SST feedback in the Indian Ocean has experienced significant decadal variations over the last 40 a. The feedback intensified in the late twentieth century and then weakened during the hiatus in global warming at the early twenty-first century. The thermoclidal variations of feedback are similar in these two regions, there are still differences in the underlying mechanisms. The decadal variations of feedback in the southeastern Indian Ocean are dominated by variations in the depth of the thermocline, which are modulated by equatorial zonal wind anomalies. Whereas the decadal variation of feedback in the southwestern Indian Ocean is mainly controlled by the intensityne-SST feedback is most prominent in the southeastern and southwestern Indian Ocean. Although the deca of upwelling and thermocline depth in winter and spring, respectively. The upwelling and thermocline depth are both affected by wind stress curl anomalies over the southeastern Indian Ocean, which excite anomalous Ekman pumping and influence the southwestern Indian Ocean through westward propagating Rossby waves.
- Published
- 2021
56. Inhibition of the Glycolysis Prevents the Cerebral Infarction Progression Through Decreasing the Lactylation Levels of LCP1
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Wei Zhang, Liang Xu, Zhenfei Yu, Meiqi Zhang, Jingquan Liu, and Jianming Zhou
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Bioengineering ,Molecular Biology ,Applied Microbiology and Biotechnology ,Biochemistry ,Biotechnology - Abstract
Cerebral infarction (CI), also known as ischemic stroke, has a high incidence rate and mortality rate. The purpose of this study was to investigate the potential effect and mechanism of Lymphocyte cytosolic protein 1 (LCP1) in the CI progression. The middle cerebral artery occlusion (MCAO) treated rats and oxygen–glucose deprivation/reoxygenation (OGD/R) stimulated PC12 cells were used to establish CI model in vivo and in vitro. The cell proliferation and apoptosis was determined by CCK-8 assay and flow cytometry, respectively. Immunoprecipitation and western blot was performed to test the lactylation levels of LCP1. The cells were treated with cycloheximide to determined the protein stability of LCP1. The glucose uptake and lactate production was determined with commercial kits. The extracellular acidification rate were evaluated by Seahorse. The results showed that LCP1 was upregulated in the MCAO rats and OGD/R stimulated PC12 cells. LCP1 knockdown dramatically decreased the neurological score, infarct volume and the brain water content of MCAO rats. Besides, LCP1 knockdown promoted the cell viability while decreased the apoptosis rate of the OGD/R stimulated PC12 cells. Additionally, the global lactylation and lactylation levels of LCP1 was prominently enhanced in vivo and in vitro in cerebral infarction. 2-DG treatment prominently decreased it. In conclusion, inhibiting the glycolysis decreased the lactylation levels of LCP1 and resulted in the degradation of LCP1, which eventually relieved the CI progression.
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- 2022
57. Occurrence and Cytotoxicity of Aliphatic and Aromatic Halogenated Disinfection Byproducts in Indoor Swimming Pool Water and Their Incoming Tap Water
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Junjie Wang, Meiqi Zhang, Shaoyang Hu, Qiming Xian, Haoran Chen, and Tingting Gong
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Environmental Chemistry ,General Chemistry - Abstract
Disinfection byproducts (DBPs) in swimming pool water are of wide concern for public health. In this study, the occurrence of five categories of aliphatic halogenated DBPs, i.e., trihalomethanes (THMs), haloacetic acids (HAAs), haloacetonitriles (HANs), halonitromethanes (HNMs), and haloketones (HKs), and six categories of aromatic halogenated DBPs, i.e., halophenols (HPs), halonitrophenols (HNPs), halohydroxy-benzaldehydes (HBALs), halohydroxybenzoic acids (HBAs), halobenzoquinones (HBQs), and haloanilines (HAs), was examined in seven indoor swimming pool water and their incoming tap water. The correlations between the DBP concentrations and water quality parameters were explored. Moreover, the cytotoxicity of the aliphatic and aromatic halogenated DBPs was tested with human hepatoma (HepG2) cells, and the concentration-cytotoxicity contributions of different DBP categories were calculated. The results demonstrate that 24 aliphatic (5 THMs, 8 HAAs, 5 HANs, 4 HNMs, and 2 HKs) and 50 aromatic halogenated DBPs (9 HPs, 8 HNPs, 9 HBALs, 8 HBAs, 11 HBQs, and 5 HAs) were present in the swimming pool water, among which 41 aromatic halogenated DBPs were detected in swimming pool water for the first time. The average concentrations of the five categories of aliphatic halogenated DBPs in the swimming pool water were in the order of HAAsHANsHKsTHMsHNMs, while those in their incoming tap water were in the order of THMsHAAsHKsHANsHNMs. The average concentrations of the aromatic halogenated DBPs in the swimming pool water were significantly lower than those of the aliphatic halogenated DBPs, following the order of HBQsHPsHBAsHBALsHAsHNPs, while those in their incoming tap water were in the order of HBALsHBQsHPsHBAsHAsHNPs. The average concentration-cytotoxicity contributions of different DBP categories in the swimming pool water followed the order of HAAsHANsHNMsHKsHBQsTHMsHPsHNPsHBAsHBALsHAs, with HAAs, HANs, and HNMs possessing the main concentration-cytotoxicity contributions (93.2% in total) among all DBP categories.
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- 2022
58. APEX2‐based Proximity Labeling of Atox1 Identifies CRIP2 as a Nuclear Copper‐binding Protein that Regulates Autophagy Activation
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Zhengcunxiao Li, Lin Chen, Jiayu Wang, Fei Li, Peng Zou, Jiaxuan Bian, Na Li, Feng Yuan, Jing Wang, Xiaomeng Shi, Changliang Shan, Meiqi Zhang, Bo Yang, Mingming Sun, and Yuan Wang
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chemistry.chemical_element ,Catalysis ,law.invention ,ATOX1 ,Copper Transport Proteins ,law ,Cell Line, Tumor ,medicine ,Autophagy ,DNA-(Apurinic or Apyrimidinic Site) Lyase ,Humans ,Protein secondary structure ,Adaptor Proteins, Signal Transducing ,biology ,General Chemistry ,General Medicine ,LIM Domain Proteins ,Endonucleases ,Copper ,Multifunctional Enzymes ,Cell biology ,medicine.anatomical_structure ,chemistry ,Chaperone (protein) ,Cancer cell ,biology.protein ,Suppressor ,Nucleus ,Molecular Chaperones - Abstract
Mammalian cell nuclei contain copper, and cancer cells are known to accumulate aberrantly high copper levels, yet the mechanisms underlying nuclear accumulation and copper's broader functional significance remain poorly understood. Here, by combining APEX2-based proximity labeling focused on the copper chaperone Atox1 with mass spectrometry we identified a previously unrecognized nuclear copper binding protein, Cysteine-rich protein 2 (CRIP2), that interacts with Atox1 in the nucleus. We show that Atox1 transfers copper to CRIP2, which induces a change in CRIP2's secondary structure that ultimately promotes its ubiquitin-mediated proteasomal degradation. Finally, we demonstrate that depletion of CRIP2-as well as copper-induced CRIP2 degradation-elevates ROS levels and activates autophagy in H1299 cells. Thus, our study establishes that CRIP2 as an autophagic suppressor protein and implicates CRIP2-mediated copper metabolism in the activation of autophagy in cancer cells.
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- 2021
59. Mapping Research Trends from 20 Years of Publications in Rhythmic Auditory Stimulation
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Meiqi Zhang, Fang Li, Dongyu Wang, Xiaohong Ba, and Zhan Liu
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Health, Toxicology and Mutagenesis ,Public Health, Environmental and Occupational Health ,auditory cueing ,motor dysfunction ,music therapy ,Parkinson’s disease - Abstract
This study aims to create an all-around insight into the evolutions, status, and global trends of rhythmic auditory stimulation (RAS) research via enhanced bibliometric methods for the 2001–2020 time period. Articles concerning RAS were extracted from the Web of Science database. CiteSpace, Bibliometrix, VOSviewer, and Graphpad Prism were employed to analyze publication patterns and research trends. A total of 586 publications related to RAS between 2001 and 2020 were retrieved from the Web of Science database. The researcher Goswami U. made the greatest contribution to this field. The University of Toronto was the institution that published the most articles. Motor dysfunction, sensory perception, and cognition are the three major domains of RAS research. Neural tracking, working memory, and neural basis may be the latest research frontiers. This study reveals the publication patterns and topic trends of RAS based on the records published between 2001 and 2020. The insights obtained provided useful references for the future research and applications of RAS.
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- 2022
60. Mapping Research Trends of Adapted Sport from 2001 to 2020: A Bibliometric Analysis
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Tao Liu, Nicole Wassell, John Liu, and Meiqi Zhang
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Biomedical Research ,Bibliometrics ,Health, Toxicology and Mutagenesis ,Public Health, Environmental and Occupational Health ,Medicine ,Sports for Persons with Disabilities ,Basketball ,adapted sport ,Paralympics ,Special Olympics ,intellectual disability ,sport injury - Abstract
Objectives: To identify the research landscape in terms of keywords, annual outputs, journals, countries, and institutions and explore the hot topics and prospects regarding adapted sport research. Materials and methods: Publications designated as “article” on adapted sport retrieved from the Web of Science Core Collection. VOSviewer 1.6.11, Citespace, and Bibliometrix in R Studio were applied for the bibliometric analyses. Results: A total of 1887 articles were identified. Over the past two decades, athletic performance, sociology/psychology, and rehabilitation were extensively investigated. Basketball, soccer, and swimming were the three most focused adapted sports. Researchers showed a growing interest in submitting their studies to sport science, rehabilitation, and sociological journals. Adapted sport research was more common in developed countries and regions. The UK contributed most publications accounting for about 20% of the total publications. Conclusions: With the growth of publications concerning adapted sport, the bibliometric analysis presented an overview of collaboration, trends, and hotspots in the field.
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- 2022
- Full Text
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61. [Mechanism of tanshinone II A inhibiting myocardial remodeling by Galectin-3]
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Meiqi, Zhang, Kang, Cheng, Limei, Yu, Weihua, Wu, Yakun, Wang, and Yun, Chen
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Heart Failure ,Rats, Sprague-Dawley ,Tissue Inhibitor of Metalloproteinase-1 ,Angiotensin II ,Galectin 3 ,Myocardium ,Abietanes ,Animals ,Matrix Metalloproteinase 2 ,Collagen ,RNA, Messenger ,Fibrosis ,Rats - Abstract
To explore the effect of tanshinone II A on myocardial remodeling in ischemia/reperfusion (I/R)-induced heart failure of rodent model.(1) In vivo, 30 SD rats were randomly divided into sham operation, heart failure and tanshinone II A treatment group, with 10 rats in each group. The I/R model was established by ligating the left coronary artery until ST segment elevation for 30 minutes, then the ligation was removed for 2 hours as reperfusion. In the sham operation group, the rat chest was opened without artery ligation. Three days after model establishment, tanshinone II A (10 mg/kg) were given intraperitoneal injected in tanshinone II A group for 9 weeks. In the other two groups, normal saline was administrated in the same way. The behavioral manifestations of the rats in each group were observed; hemodynamic indexes were evaluated; Masson staining was performed to observe the degree of myocardial fibrosis; enzyme linked immunosorbent assay (ELISA) was used to detect the content of Galectin-3 in myocardial tissue; quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was used to detect the expressions of collagen III, collagen I, matrix metalloproteinase 2 (MMP-2) and tissue inhibitor of metalloproteinase (TIMP-1). (2) In vitro, rats primary cardiac fibroblasts were extracted and isolated, and divided into blank control group, angiotensin II group (7-10 mmol/L angiotensin II) and angiotensin II + tanshinone II A group (7-10 mmol/L angiotensin II + 5-10 mmol/L tanshinone II A). At 24 hours and 48 hours of culture, the cell proliferation in each group was detected by methyl thiazolyl tetrazolium (MTT); the expressions of collagen III, collagen I, MMP-2 and TIMP-1 were detected by qRT-PCR; the content of Galectin-3 in cardiac fibroblasts was detected by ELSIA.(1) In vivo, the rats' activity status, hair conformity and food intake were ranked from good to bad in order of sham operation group, tanshinone II A group and heart failure model group. Compared with the sham-operated group, the heart rate (HR) of the rats in the heart failure model group was significantly decreased and the heart function was significantly impaired. The mRNA and protein expression of collagen I, collagen III, TIMP-1 and Galectin-3 content were significantly increased, while the mRNA and protein expression of MMP-2 were significantly decreased. Compared with the heart failure model group, rats in the tanshinone II A group showed significantly higher HR and improved cardiac function, significantly lower mRNA expression of collagen I and collagen III, significantly lower mRNA and protein expression of TIMP-1 and Galectin-3, and significantly higher mRNA and protein expression of MMP-2, and the most obvious changes were in the 9th weeks of modeling [collagen I mRNA (2Tanshinone II A can improve cardiac function, inhibit myocardial fibrosis and improve myocardial remodeling in rats with I/R-induced heart failure.
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- 2022
62. Isoliquiritigenin inhibits virus replication and virus-mediated inflammation via NRF2 signaling
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Haojia Wang, Xin Jia, Meiqi Zhang, Cuiqin Cheng, Xue Liang, Xuejiao Wang, Fang Xie, Jinyong Wang, Yanli Yu, Yuting He, Qiutong Dong, Yao Wang, and Anlong Xu
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Pharmacology ,Complementary and alternative medicine ,Drug Discovery ,Pharmaceutical Science ,Molecular Medicine - Published
- 2023
63. LncRNA AK020546 protects against cardiac ischemia–reperfusion injury by sponging miR-350-3p
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Kang Cheng, Jianfeng Tu, Ye Shen, Zhenfei Yu, Meiqi Zhang, Lingxiao Pang, Huan Chen, and Weihua Wu
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Aging ,Cardiotonic Agents ,Receptor, ErbB-3 ,Ischemia ,Down-Regulation ,Apoptosis ,Caspase 3 ,medicine.disease_cause ,Cell Line ,miR-350-3p ,cardiac ischemia reperfusion ,chemistry.chemical_compound ,lncRNA ,medicine ,Animals ,Myocytes, Cardiac ,Rats, Wistar ,chemistry.chemical_classification ,Gene knockdown ,Reactive oxygen species ,Base Sequence ,Competing endogenous RNA ,Myocardium ,Hydrogen Peroxide ,Cell Biology ,Malondialdehyde ,medicine.disease ,MicroRNAs ,Oxidative Stress ,chemistry ,Reperfusion Injury ,Cancer research ,RNA, Long Noncoding ,Proto-Oncogene Proteins c-akt ,Reperfusion injury ,Oxidative stress ,Signal Transduction ,Research Paper - Abstract
Long non-coding RNAs (lncRNAs) have been implicated in the development of cardiovascular diseases. We observed that lncRNA AK020546 was downregulated following ischemia/reperfusion injury to the myocardium and following H2O2 treatment in H9c2 cardiomyocytes. In vivo and in vitro studies showed that AK020546 overexpression attenuated the size of the ischemic area, reduced apoptosis among H9c2 cardiomyocytes, and suppressed the release of reactive oxygen species, lactic acid dehydrogenase, and malondialdehyde. AK020546 served as a competing endogenous RNA for miR-350-3p and activated the miR-350-3p target gene ErbB3. MiR-350-3p overexpression reversed the effects of AK020546 on oxidative stress injury and apoptosis in H9c2 cardiomyocytes. Moreover, ErbB3 knockdown alleviated the effects of AK020546 on the expression of ErbB3, Bcl-2, phosphorylated AKT, cleaved Caspase 3, and phosphorylated Bad. These findings suggest lncRNA AK020546 protects against ischemia/reperfusion and oxidative stress injury by sequestering miR-350-3p and activating ErbB3, which highlights its potential as a therapeutic target for ischemic heart diseases.
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- 2021
64. A Ratiometric Fluorescent Biosensor Reveals Dynamic Regulation of Long‐Chain Fatty Acyl‐CoA Esters Metabolism
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Jing Wang, Meiqi Zhang, Guang-Fu Yang, Yuan Wang, Renyu Qu, Jiayuan Zhang, Chuchen Wang, Qingpeng Wei, and Weibo Wang
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chemistry.chemical_classification ,010405 organic chemistry ,Chemistry ,Binding protein ,Esters ,Endogeny ,General Medicine ,Biosensing Techniques ,General Chemistry ,Protein engineering ,Metabolism ,010402 general chemistry ,01 natural sciences ,Fluorescence ,Catalysis ,0104 chemical sciences ,Cell biology ,Cytosol ,Acyl-CoA ,chemistry.chemical_compound ,HEK293 Cells ,Enzyme ,Humans ,Acyl Coenzyme A ,Biosensor - Abstract
Despite increasing awareness of the biological impacts of long-chain fatty acyl-CoA esters (LCACoAs), our knowledge about the subcellular distribution and regulatory functions of these acyl-CoA molecules is limited by a lack of methods for detecting LCACoAs in living cells. Here, we report development of a genetically encoded fluorescent sensor that enables ratiometric quantification of LCACoAs in living cells and subcellular compartments. We demonstrate how this FadR-cpYFP fusion "LACSer sensor" undergoes LCACoA-induced conformational changes reflected in easily detectable fluorescence responses, and show proof-of-concept for real-time monitoring of LCACoAs in human cells. Subsequently, we applied LACSer to investigate how disruption of ACSL enzymes differentially reduces cytosolic and mitochondrial LCACoA levels, and show how genetic disruption of an acyl-CoA binding protein (ACBP) alters mitochondrial accumulation of LCACoAs. Thus, our LACSer sensor achieves spatiotemporally precise detection of dynamic changes in endogenous LCACoA levels in living cells and yields mechanistic insights about metabolism and cellular regulation .
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- 2021
65. Monitoring the Dynamic Regulation of the Mitochondrial GTP‐to‐GDP Ratio with a Genetically Encoded Fluorescent Biosensor
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Meiqi Zhang, Bo Yang, Jiayuan Zhang, Yuxin Song, Weibo Wang, Na Li, Yuan Wang, Wenzhe Li, and Jing Wang
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Succinate-CoA Ligases ,General Medicine ,Biosensing Techniques ,Guanosine Triphosphate ,General Chemistry ,Guanosine Diphosphate ,Catalysis ,Mitochondria - Abstract
The interconversion of guanosine triphosphate (GTP) and guanosine diphosphate (GDP) is known to be integral to a wide variety of biological cellular activities, yet to date there are no analytical methods available to directly detect the ratio of intracellular GTP to GDP. Herein, we report GRISerHR, a genetically encoded fluorescent biosensor to monitor the GTP : GDP ratio in multiple cell types and in various organelles under metabolic perturbation. Additionally, we characterized the differential mitochondrial GTP : GDP ratios resulting from genetic modulation of two isoforms of a tricarboxylic acid (TCA) cycle enzyme (succinyl-CoA synthetase; SCS-ATP and SCS-GTP) and of a phosphoenolpyruvate (PEP) cycle enzyme (PEPCK-M). Thus, our GRISerHR sensor achieves spatiotemporally precise detection of dynamic changes in the endogenous GTP : GDP ratio in living cells and can help deepen our understanding about the energy metabolic contributions of guanosine nucleotides in biology.
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- 2022
66. Video super-resolution reconstruction of weak and small target in sea background based on channel attention mechanism
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Rui Zhang, Meiqi Zhang, Zhiyong Chen, Yan Ouyang, Junyu Guo, Jia He, and Jing Hu
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- 2022
67. Emergency stress management among nurses: A lesson from the COVID‐19 outbreak in China–a cross‐sectional study
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Changju Liao, Cuicui Zhang, Linghong Guo, Meiqi Zhang, Ying Zhong, Qingfang Lin, Yin Liu, and Wenjing Jiang
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Adult ,Male ,China ,Stress management ,medicine.medical_specialty ,Cross-sectional study ,Nursing Staff, Hospital ,03 medical and health sciences ,Social support ,0302 clinical medicine ,Surveys and Questionnaires ,Pandemic ,medicine ,Humans ,Acute stress reaction ,030212 general & internal medicine ,General Nursing ,Self-efficacy ,030504 nursing ,business.industry ,COVID-19 ,Social Support ,General Medicine ,medicine.disease ,Mental health ,Self Efficacy ,Checklist ,Cross-Sectional Studies ,Mental Health ,Family medicine ,Female ,Emergency Service, Hospital ,0305 other medical science ,business - Abstract
Aims and objectives To assess the level of stress response, self-efficacy and perceived social support status of working nurses during the outbreak of the COVID-19 and investigate potential factors affecting their stress. Background The stress level of clinical nurses directly affects their physical and mental health and work efficiency. Design This study was a cross-sectional investigation, which was performed following the STROBE checklist. The current study was conducted in February 2020 by selecting clinical nurses from the Zigong First People's Hospital for investigation. Methods At the peak of the COVID-19 outbreak in China, we assessed clinical nurses with the Stanford Acute Stress Reaction Questionnaire, the General Self-Efficacy Scale and the Perceived Social Support Scale. Specifically, the nurses were divided into three groups: (a) nurses supporting Wuhan; (b) nurses in the department of treating the COVID-19 patients in our hospital (epidemic department); and (c) nurses in the general department without the COVID-19 patients in our hospital (non-epidemic department). Results A total of 1092 clinical nurses were surveyed with 94 nurses in Wuhan, 130 nurses treating COVID-19 patients in our hospital and 868 nurses working without direct contact with diagnosed COVID-19 patients. The mean stress score of all surveyed nurses was 33.15 (SD: 25.551). There was a statistically significant difference in stress response scores between different departments. Noticeably, the nurses who went to support in Wuhan showed a weaker stress response than the nurses who stayed in our hospital (mean: 19.98 (Wuhan) vs. 32.70 (epidemic department in our hospital) vs. 34.64 (non-epidemic department in our hospital)). In addition, stress was negatively correlated with general self-efficacy and perceived social support. Conclusion The present study suggested that the stress status of second-line nurse without direct contact with diagnosed COVID-19 patients was more severe than that of first-line nurses who had direct contact with COVID-19 patients. Relevance to clinical practice Our study indicated the importance of psychological status of second-line medical staff during the global pandemic.
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- 2020
68. Changes of antibiotic concentrations in patients with severe infection treated with continuous renal replacement therapy
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Zhenfei YU, Fang HAN, Meiqi ZHANG, Weihua WU, Kang CHENG, and Peng AN
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General Medicine - Published
- 2022
69. Tanshinone IIA alleviates cardiac hypertrophy through m6A modification of galectin-3
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Meiqi Zhang, Yun Chen, Huan Chen, Ye Shen, Lingxiao Pang, Weihua Wu, and Zhenfei Yu
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Male ,Galectin 3 ,Bioengineering ,Cardiomegaly ,Salvia miltiorrhiza ,General Medicine ,Applied Microbiology and Biotechnology ,Methylation ,Mice, Inbred C57BL ,Mice ,Abietanes ,Animals ,Humans ,Biotechnology ,Drugs, Chinese Herbal ,Signal Transduction - Abstract
Cardiac hypertrophy results from the adaptive response of the myocardium to pressure overload on the heart. Tanshinone IIA (Tan IIA) is the major active compound extracted from
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- 2022
70. Evaluation of Tourism Environmental Carrying Capacity in Diaoshuihu National Forest Park
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Jia Li, Yunhe Wang, and Meiqi Zhang
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Renewable Energy, Sustainability and the Environment ,business.industry ,Geography, Planning and Development ,Environmental resource management ,Carrying capacity ,Business ,National forest ,Management, Monitoring, Policy and Law ,Tourism - Published
- 2020
71. Formation and Decomposition of New Iodinated Halobenzoquinones during Chloramination in Drinking Water
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Qiming Xian, He-Te Zhu, Shaoyang Hu, Zhijun Huang, Zhigang Li, Haoran Chen, Meiqi Zhang, Junjie Wang, and Tingting Gong
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chemistry.chemical_classification ,Halogenation ,Drinking Water ,Iodide ,General Chemistry ,Iodides ,010501 environmental sciences ,01 natural sciences ,Decomposition ,Natural organic matter ,Water Purification ,Disinfection ,Reaction rate constant ,chemistry ,Environmental chemistry ,Environmental Chemistry ,Chloramination ,Water Pollutants, Chemical ,Disinfectants ,0105 earth and related environmental sciences - Abstract
Previously four chlorinated and brominated halo-benzoquinones were reported as new disinfection byproducts (DBPs) in drinking water, which have drawn great concern due to their high toxicity. In this study, three new iodinated halobenzoquinones, including 2-chloro-6-iodo-1,4-benzoquinone (2,6-CIBQ), 2-bromo-6-iodo-1,4-benzoquinone (2,6-BIBQ), and 2,6-diiodo-1,4-benzoquinone (2,6-DIBQ), were detected and identified in drinking water for the first time. Their cytotoxicity was evaluated, and their formation under various conditions was examined. Since they were not stable during chloramination, their further decomposition during chloramination was also explored. The results indicated that the concentrations of 2,6-CIBQ, 2,6-BIBQ, and 2,6-DIBQ in drinking water were in the ranges of 0.7-1.3, 1.8-8.0, and 0.4-15.9 ng/L, respectively. Compared with 2,6-dibromo-1,4-benzoquinone, the iodinated halobenzoquinones were generally more cytotoxic. The formation of 2,6-DIBQ during chloramination was significantly affected by the iodide concentration, pH, and natural organic matter. The five tested iodinated halobenzoquinones decomposed during chloramination following pseudo-first-order decay, with the decomposition rate constants in the rank order of 2,6-CIBQ > 2,6-BIBQ > 2,6-DIBQ > 2,3-diiodo-1,4-benzoquinone >2-iodo-1,4-benzoquinone. Nine polar halogenated intermediates as well as ten aliphatic halogenated DBPs were detected as the decomposition products of 2,6-DIBQ during chloramination, based on which the decomposition pathways of 2,6-DIBQ during chloramination were proposed and verified.
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- 2020
72. Ni(OH)2-modified SrTiO3 for enhanced photocatalytic hydrogen evolution reactions
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Liang Tang, Jinyi Chen, Shaohua Yang, Wenqian Chen, and Meiqi Zhang
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Composite number ,Inorganic chemistry ,Oxide ,Nanoparticle ,General Chemistry ,Catalysis ,chemistry.chemical_compound ,chemistry ,Materials Chemistry ,Photocatalysis ,Strontium titanate ,Chemical stability ,Irradiation ,Spectroscopy - Abstract
Strontium titanate (SrTiO3) is a promising photocatalyst because of its high chemical stability and excellent photocatalytic activity. However, the requirement of near-ultraviolet (UV) irradiation for effective photocatalysis limits its practical application. In this work, we prepared a novel Ni(OH)2-modified SrTiO3 composite using a simple precipitation method and confirmed that the Ni(OH)2 nanoparticles were successfully deposited on the SrTiO3 surface rather than incorporated into the lattice. The optimal Ni(OH)2 loading amount for high H2 evolution was found to be 20%, giving an activation rate of up to 1.46 mmol h−1 g−1, which is ca. 15 times higher than that of the pure SrTiO3. This significant enhancement of activity could be ascribed to the lower recombination of electrons and holes in the presence of Ni(OH)2, which was confirmed by photo-luminescence spectroscopy (PL) and photo-current response property. The present finding could shed light on the design of efficient perovskite-type oxide based photocatalysts.
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- 2020
73. Enhanced electron transfer and photocatalytic hydrogen production over the carbon nitride/porphyrin nanohybrid finely bridged by special copper
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Kun Zhu, Shi-Zhao Kang, Meiqi Zhang, Xiangqing Li, and Lixia Qin
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Materials science ,Graphitic carbon nitride ,chemistry.chemical_element ,Porphyrin ,Copper ,Catalysis ,chemistry.chemical_compound ,Electron transfer ,chemistry ,Chemical engineering ,Photocatalysis ,Carbon nitride ,Hydrogen production - Abstract
This work proposes a novel carbon nitride-based hybrid (g-C3N4/Cu/THPP) with small-sized Cu as the bridging linker for improving the photocatalytic activity of graphitic carbon nitride (g-C3N4)/tetrakis-(4-hydroxyphenyl)porphyrin (THPP). It was found that the special Cu linker had a great influence on the microstructure and photocatalytic H2 production of the C3N4/THPP nanohybrid. The photocatalytic activity was enhanced by about 17.3 times compared to that of pristine g-C3N4 and about 11.6 times higher than that of g-C3N4/THPP. Especially, it was enhanced by about 3.1 times than that of g-C3N4/CuTHPP (a comparative composite without the Cu bridge). Furthermore, the photocatalysis mechanism was investigated in detail. The results demonstrated that interfacial modification with the special Cu linker was key in improving the absorption, electron/hole separation and photocatalytic performance of the nanohybrid. This work provides a facile strategy for preparing highly efficient photocatalysts through interfacial modifications with special metals.
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- 2020
74. Green Product Supply Chain Coordination Under Demand Uncertainty
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Meiqi Zhang, Chong Xin, Haifeng Chen, Xin Chen, and Shuangrui Chen
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coordination ,General Computer Science ,Supply chain ,green product ,Tariff ,010501 environmental sciences ,01 natural sciences ,0502 economics and business ,Stackelberg competition ,Revenue ,General Materials Science ,Product (category theory) ,Industrial organization ,0105 earth and related environmental sciences ,05 social sciences ,General Engineering ,Variance (accounting) ,Decentralised system ,green marketing ,demand uncertainty ,Green marketing ,lcsh:Electrical engineering. Electronics. Nuclear engineering ,Business ,lcsh:TK1-9971 ,050203 business & management - Abstract
The problem of coordinating a two-echelon green product supply chain with environmentally conscious consumers under demand uncertainty is studied in this paper. In the green product supply chain, a manufacturer produces green product through developing green technology and a retailer promotes the green product through green marketing. The demand of the green product is uncertain with the mean and the variance as the only known information. After analyzing the utility that a consumer gained from the green product, the problem is then formulated as a distribution-free-based Stackelberg game for a decentralized system under three contracts, i.e., wholesale price-only (WPO), revenue and green marketing cost-sharing (RGMS), and two-part tariff (TPTF) contracts. The analytical results are also proposed to show the effects of the system parameters on supply chain optimal decisions. By comparing with the centralized system, the coordination level for each contract is investigated. Numerical examples and sensitivity analysis with respect to several system parameters are presented to illustrate the effectiveness of the contracts under demand uncertainty. The results demonstrate that both RGMS and TPTF contracts are superior to WPO contract. Especially, TPTF contract can always coordinate the supply chain, while RGMS contract can improve the supply chain coordination level only if the revenue and cost sharing coefficients satisfy certain conditions.
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- 2020
75. Genetic Diversity and Population Structure of Traditional Chinese Herb 'Chai-Hu' Resources Using Genome-Wide SNPs Through Genotyping-By-Sequencing
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Ming Jiang, Song Yan, Weichao Ren, Nannan Xing, Hongyuan Li, Meiqi Zhang, Meiqi Liu, and Wei Ma
- Abstract
Bupleurum (named “Chai-hu”) is an important traditional Chinese medicine resource in China. It has been widely used since ancient times and has antipyretic, analgesic and cholagogic functions, but there is little research on its genetic diversity. In this study, genotyping-by-sequencing (GBS) was used to detect SNP loci in 39 Bupleurum germplasm resources from different regions in China and analyse their genetic diversity. A total of 25.1 Gb of data was obtained by sequencing, with an average of 0.64 Gb per sample. After screening, 83898 high-quality SNPs were obtained. The results of genetic research were obtained by phylogenetic tree, principal component analysis and population structure analysis, and the 39 experimental materials were divided into three groups. The average observed heterozygosity and expected heterozygosity of Bupleurum populations were 0.24 and 0.17, respectively, indicating that Bupleurum populations from five different provinces had a low level of genetic diversity. Population nucleotide diversity analysis and analysis of molecular variance showed that the percentage of intrapopulation variation was 120.88%, while the percentage of interpopulation variation was only 2.46%. There was relative aggregation of Bupleurum samples with the same geographical origin, but the division of population structure was not completely correlated with sample origin. The results showed that the genetic diversity of the materials was low and that the genetic variation was narrow. This provides a good basis for the genetic breeding and protection of species diversity of Bupleurum.
- Published
- 2022
76. Application of Alkyl Amidopropyl Betaine in Fire Fighting Foam Extinguishing Agent
- Author
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Jiancheng Zhang, Zeyao Shi, Meiqi Zhang, and Liusuo Wu
- Subjects
General Medicine - Abstract
In order to improve the fire extinguishing performance of foam fire extinguishing agents in nonpolar liquid fires, the application of alkyl amidopropyl betaine with different chain lengths in aqueous film-forming foam fire extinguishing agents was studied. The relationship between the structure of alkylamidopropyl betaine and surface tension, foaming property and foam stability was analyzed. On this basis, different foam fire extinguishing agent formulations were formed, and then the surface tension, foam performance and fire extinguishing performance of each formulation were tested. The results show that the alkyl chain of alkylamidopropyl betaine is directly proportional to the foaming property. The shorter the alkyl chain, the less oily the foam is and the better the foam’s anti-burning performance. The combination of alkylamidopropyl betaine with different chain lengths is conducive to comprehensive product foam performance and oleophobic performance to achieve the best fire extinguishing effect.
- Published
- 2023
77. CircRBM33 downregulation inhibits hypoxia-induced glycolysis and promotes apoptosis of breast cancer cells via a microRNA-542-3p/HIF-1α axis
- Author
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Yiming Jiang, Meiqi Zhang, Danlu Yu, Guoxin Hou, Jingyi Wu, and Fuming Li
- Subjects
Cancer Research ,Cellular and Molecular Neuroscience ,Immunology ,Cell Biology ,skin and connective tissue diseases - Abstract
Many circRNAs are involved in the carcinogenesis of breast cancer (BCa) through the transcription of microRNAs (miRNAs) and mRNAs. This study investigated circRBM33 regulation of the miR-542-3p/hypoxia-inducible factor-1α (HIF-1α) axis in BCa. BCa clinical tissue samples were collected to test differential expressions of circRBM33, miR-542-3p, and HIF-1α. MCF-7 cells were subjected to normoxia or hypoxia and transfected with plasmids that regulated CircRBM33, miR-542-3p, and HIF-1α expression levels. Glycolysis was evaluated by measuring glucose consumption, lactic acid production, and protein expression of hexokinase 2, glucose transporter type 1 and lactic dehydrogenase A. Cell proliferation and apoptosis were also assessed, and the interactions between genes were explored. CircRBM33 and HIF-1α were upregulated, while miR-542-3p was downregulated in BCa tissue samples and cell lines. Hypoxia induced circRBM33 expression in BCa cells, which negatively regulated miR-542-3p expression. CircRBM33 knockdown or miR-542-3p rescue reduced glycolysis and proliferation and promoted apoptosis of BCa cells. MiR-542-3p inhibition rescued circRBM33 knockdown-mediated glycolysis, proliferation and apoptosis of BCa cells. MiR-542-3p targeted HIF-1α, and the overexpression of HIF-1α reversed the effect of miR-542-3p upregulation on glycolysis, proliferation, and apoptosis of BCa cells. Collectively, downregulating circRBM33 suppresses miR-542-3p-targeted HIF-1α expression, resulting in the inhibition of glycolysis and proliferation and the promotion of BCa cells’ apoptosis.
- Published
- 2021
78. Between escape and return: Rethinking daily life and travel in selective unplugging
- Author
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Meiqi Zhang and Xiaoming Zhang
- Subjects
Strategy and Management ,Tourism, Leisure and Hospitality Management ,Transportation ,Development - Published
- 2022
79. [Corrigendum] MicroRNA‑122 affects cell aggressiveness and apoptosis by targeting PKM2 in human hepatocellular carcinoma
- Author
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Jianfeng Tu, Wenwei Cai, Meiqi Zhang, Linxiao Pang, Qiuran Xu, and Xin Liu
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,Internal medicine ,microRNA ,medicine ,General Medicine ,Psychology - Abstract
Following the publication of the above article, an interested reader drew to the authors' attention that Figs. 6C and 7A apparently contained overlapping panels, suggesting that these data for purportedly different experiments had been derived from the same original source. The wound‑healing result for the anti‑miR‑122+siRNA PKM2 experiment in the lower panel of Fig. 6C and the transwell invasion result for the anti‑miR‑122+siRNA PKM2 experiment in Fig. 7A were erroneously selected. Accordingly, the authors repeated these assays and were able to confirm that the results were in accordance with the published results. Consequently, the corrected versions of Figs. 6 and 7, containing the replacement data for Figs. 6C and 7A, are shown opposite. It should be emphasized that the inadvertent errors that occurred during the compilation of these figures did not affect the research results or the conclusions of this article. The authors all agree to this Corrigendum, and are grateful to the Editor of Oncology Reports for allowing them to have the opportunity to correct these errors. The authors also apologize to the readership for any inconvenience these errors may have caused. [the original article was published in Oncology Reports 34: 2054‑2064, 2015; DOI: 10.3892/or.2015.4175].
- Published
- 2021
80. Lake Level Controls on Oil Shale Distribution in the Lucaogou Formation, Wujiawan Area, Junggar Basin, Northwest China
- Author
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Yue Li, Jun-Xian Wang, Yuanji Li, Pingchang Sun, Zhaojun Liu, and Meiqi Zhang
- Subjects
Fuel Technology ,Permian ,business.industry ,General Chemical Engineering ,Geochemistry ,Energy Engineering and Power Technology ,Distribution (economics) ,Thick section ,Structural basin ,China ,business ,Oil shale ,Geology - Abstract
In a thick section of the upper Permian, high-quality oil shale is present in the Lucaogou Formation on the northern flanks of Bogda Mountain, which is located in the southern Junggar Basin, northw...
- Published
- 2019
81. Bandgap Modulation of Dithienonaphthalene-Based Small-Molecule Acceptors for Nonfullerene Organic Solar Cells
- Author
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中国科学院大学,北京, Yunlong Ma, Meiqi Zhang, Qingdong Zheng, and 中国科学院福建物质结构研究所,结构化学国家重点实验室,福州
- Subjects
Materials science ,Organic solar cell ,Modulation ,business.industry ,Band gap ,Optoelectronics ,Physical and Theoretical Chemistry ,business ,Small molecule - Published
- 2019
82. An Exploration of the Localization of Portuguese Teaching Theories in China
- Author
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Meiqi Zhang
- Abstract
In order to explore the localization teaching theory of Portuguese in Chinese colleges and universities, the author reviewed the development process of Chinese foreign language teaching theory and combined with the actual situation, and found that the communicative teaching method and the "Production-oriented Approach" are expected to play a key role in the teaching of Portuguese in my country. The article cites examples of classroom operations, aiming to "introduce bricks and stones" for the majority of Portuguese teaching researchers, with a view to the emergence of more localized Portuguese teaching theories in line with the laws of China's development in the future.
- Published
- 2022
83. The Effects of a 10-Week Neuromuscular Training on Postural Control in Elite Youth Competitive Ballroom Dancers: A Randomized Controlled Trial
- Author
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Meiqi Zhang, Hongtao Ma, Zhan Liu, Daniel M. Smith, and Xiao Wang
- Subjects
medicine.medical_specialty ,Scoring system ,Physiology ,Ballroom ,postural control ,lcsh:Physiology ,Lower limb ,Postural control ,law.invention ,Ballroom dance ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Physiology (medical) ,neuromuscular training ,ballroom dance ,medicine ,Original Research ,lcsh:QP1-981 ,business.industry ,030229 sport sciences ,Neuromuscular training ,dancer ,Physical therapy ,athletic performance ,business ,030217 neurology & neurosurgery - Abstract
The purpose of this randomized controlled trial was to evaluate the efficacy of a 10-week neuromuscular training (NMT) program on the postural control of elite youth competitive ballroom dancers. Forty-two dancers (21 couples) were randomly assigned to either the NMT group (n= 22) or the control group (CG;n= 20). Participants in NMT underwent a three-sessions-per-week NMT program for 10 weeks. Testing at baseline and after the 10 weeks intervention included the Y-balance test (YBT) and Modified-Balance Error Scoring System (M-BESS). Results of YBT indicated that NMT participants demonstrated increased reach in the posterolateral and posteromedial directions for the right and left lower limb, whereas no significant change was found in the anterior direction for both limbs. Results of Modified-Balance Error Scoring System (M-BESS) showed that NMT participants displayed significantly decreased errors of the double-leg floor (p= 0.026), single-leg foam (p= 0.010), double-leg foam (p= 0.003), tandem floor (p= 0.031), and tandem foam (p= 0.038), while no significant change was found in single-leg floor performance (p= 0.476). CG participants did not exhibit any significant change during the 10-week period. In summary, the study affirmed that the 10-week NMT program enhanced the postural control performance of youth ballroom dancers and showed effects on ballroom dance-specific performance and lower-limb injury prevention. The results suggest that NMT may be a valuable addition to ballroom dance training regimens.
- Published
- 2020
84. Changes of antibiotic concentrations in patients with severe infection treated with continuous renal replacement therapy.
- Author
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Zhenfei YU, Fang HAN, Meiqi ZHANG, Weihua WU, Kang CHENG, and Peng AN
- Published
- 2024
- Full Text
- View/download PDF
85. Characterization of the complete chloroplast genome of Sanicula rubriflora F. Schmidt ex Maxim
- Author
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Weichao Ren, Wei Ma, Meiqi Zhang, Zhen Wang, Yunwei Liu, and Song Yan
- Subjects
0106 biological sciences ,0301 basic medicine ,Genetics ,Phylogenetic tree ,Inverted repeat ,food and beverages ,Biology ,biology.organism_classification ,010603 evolutionary biology ,01 natural sciences ,Genome ,Sanicula ,03 medical and health sciences ,030104 developmental biology ,Phylogenetics ,Transfer RNA ,Molecular Biology ,Gene ,GC-content - Abstract
Sanicula rubriflora refers to a kind of edible wild herbs, which possesses reputed medicinal value. Chloroplasts (cp) is essential organelle in plant cells and has a genome that can be inherited autonomously. The complete chloroplast genome of S. rubriflora was assemble and annotated in the present study. It was a circular molecular genome with a size of 155,700 bp in length, which has a typical quadripartite structure. For instance, a large single-copy (LSC) of 85,979 bp and a pair of inverted repeats (IRs) of 26,333 bp were disconnected by a small single-copy (SSC) of 17,053bp. A total of 130 genes have been annotated, including 86 protein-coding genes (PCGs), 36 transfer RNA genes (tRNAs) and 8 ribosomal RNA genes (rRNAs). The total GC content of the complete chloroplast genome reached 37.9%. A maximum likelihood phylogenetic analysis with the reported chloroplast genomes revealed that S. rubriflora is most closely related to Saniculachinensis in the phylogenetic relationships.
- Published
- 2021
86. Chronic Physical Activity for Attention Deficit Hyperactivity Disorder and/or Autism Spectrum Disorder in Children: A Meta-Analysis of Randomized Controlled Trials
- Author
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Zhan Liu, Meiqi Zhang, Hongtao Ma, and Daniel M. Smith
- Subjects
medicine.medical_specialty ,Cognitive Neuroscience ,Gross motor skill ,physical activity ,ASD ,lcsh:RC321-571 ,law.invention ,03 medical and health sciences ,Behavioral Neuroscience ,0302 clinical medicine ,children ,Randomized controlled trial ,law ,medicine ,ADHD ,Attention deficit hyperactivity disorder ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,Motor skill ,030304 developmental biology ,0303 health sciences ,motor skills ,business.industry ,Cognitive flexibility ,medicine.disease ,Neuropsychology and Physiological Psychology ,executive function ,Strictly standardized mean difference ,Autism spectrum disorder ,Meta-analysis ,Physical therapy ,Systematic Review ,business ,030217 neurology & neurosurgery - Abstract
Purpose: To explore the effects of physical activity (PA) intervention on executive function (EF) and motor skills (MS) among children with attention deficit hyperactivity disorder and/or autism spectrum disorder (ASD). Methods: Relevant studies were sourced from PubMed, Web of Science, EMBASE, Cochrane Library, CNKI and Wanfang Data. Only randomized controlled trials (RCT) were included based upon the following criteria: (1) participants were children and clinically diagnosed with ADHD/ASD, (2) intervention strategies were identified as chronic physical activity, and (3) EF (e.g., cognitive flexibility) and/or MS (e.g., gross motor skills) were measured at baseline and post-intervention and compared with an eligible control group. Results: Eleven studies involving 346 participants were finally identified. PA elicited significant improvements in EF and MS in children with ADHD/ASD. Regarding changes in the EF of participants, PA showed a great improvement in overall EF [standardized mean difference (SMD): 0.90, 95% confidence interval (CI) 0.49-1.30, p < 0.00001], inhibitory control (SMD: 1.30, 95% CI 0.58-2.02, p = 0.0004) and cognitive flexibility (SMD: 0.85, 95% CI 0.42-1.29, p = 0.0001), but no significant improvement in working memory (SMD: 0.28, 95% CI -0.15-0.71, p = 0.20). Significant improvements were also found with respect to gross motor skills (SMD: 0.80, 95% CI 0.30-1.30, p = 0.002), but no significant changes were found in fine motor skills (SMD: 0.30, 95% CI -0.91-1.52, p = 0.62). Conclusion: Chronic PA interventions may promote EF and MS in children with ADHD/ASD, especially in inhibitory control, cognitive flexibility, and gross motor skills. However, PA interventions seemed to have insignificant effects on working memory and fine motor skills to children with ADHD/ASD. PROSPERO registration number: CRD42019118622.
- Published
- 2020
87. MicroRNA-27 attenuates pressure overload-Induced cardiac hypertrophy and dysfunction by targeting galectin-3
- Author
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Lingxiao Pang, Weihua Wu, Meiqi Zhang, Kang Cheng, Jianfeng Tu, Ye Shen, and Huan Chen
- Subjects
0301 basic medicine ,Cardiac function curve ,Male ,medicine.medical_specialty ,Galectin 3 ,Biophysics ,Down-Regulation ,Cardiomegaly ,Biochemistry ,Muscle hypertrophy ,03 medical and health sciences ,In vivo ,Internal medicine ,microRNA ,medicine ,Animals ,Myocytes, Cardiac ,Molecular Biology ,Cells, Cultured ,Pressure overload ,Ejection fraction ,030102 biochemistry & molecular biology ,business.industry ,In vitro ,Up-Regulation ,Mice, Inbred C57BL ,MicroRNAs ,030104 developmental biology ,Galectin-3 ,cardiovascular system ,Cardiology ,business - Abstract
Cardiac hypertrophy is an adaptive response to hemodynamic stress to compensate for cardiac dysfunction. MicroRNAs can regulate cardiac function and play a vital role in the regulation of cardiac hypertrophy. In the current study, in vivo and vitro hypertrophy models are established to explore the role of miR-27b and to elucidate the underlying mechanism in cardiac hypertrophy. Expression of miR-27b was down-regulated in mice with cardiac hypertrophy. The cardiac function of the mice with cardiac hypertrophy could be restored with the overexpression of miR-27b, this is observed in terms of decreasing LVEDd, LVESd, and increasing LVFS, LVEF. This study also predicted and confirmed that galectin-3 is a target gene of miR-27b. Depletion of galectin-3 significantly attenuated hypertrophy of hearts in both in vitro and in vivo tests. In conclusion, MiR-27b be used to exert a protective role against cardiac dysfunction and hypertrophy by decreasing the expression level of galectin-3. The methodology suggested in this study provides a novel therapeutic strategy against cardiac hypertrophy.
- Published
- 2020
88. Recent advances in copper chaperone and cancer
- Author
-
Lin Chen, Meiqi Zhang, and Jing Wang
- Subjects
biology ,Cellular respiration ,General Chemical Engineering ,chemistry.chemical_element ,General Chemistry ,medicine.disease_cause ,Biochemistry ,Copper ,Cofactor ,Cell biology ,ATOX1 ,chemistry ,COX17 ,Chaperone (protein) ,Materials Chemistry ,biology.protein ,medicine ,Intracellular ,Oxidative stress - Abstract
Copper is a redox-active transition metal essential for most living organisms and serves as a catalytic cofactor for enzymes that function in antioxidant defence, iron homeostasis, cellular respiration and a variety of biochemical processes. However, intracellular free copper must be strictly limited because of its potential toxic side effects. Copper dyshomeostasis is involved in the pathogenesis and progression of diseases including cancer and neurodegenerative diseases. The uncontrolled accumulation of copper could lead to increased oxidative stress and inappropriate binding to macromolecules. Most cells evolve complex systems of copper regulation and trafficking to satisfy the cellular copper requirements and simultaneously minimize the potential toxicity. This review presents the importance of copper transporter Ctr1, copper chaperone CCS, Atox1 and COX17 for the maintenance of copper ion balance in cells. Moreover, we discuss recent highlights in the development of copper chelators for the treatment of cancer. Finally, we introduce the development of small molecules that alter copper homeostasis by inhibiting copper chaperones.
- Published
- 2018
89. Radiative lifetimes, branching fractions, and oscillator strengths of high-lying levels in Re I
- Author
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Lina Zhou, Meiqi Zhang, Qiu Li, Zhenwen Dai, Patrick Palmeri, Pascal Quinet, Sébastien Gamrath, Qi Yu, and Yongfan Li
- Subjects
Physics ,Space and Planetary Science ,Radiative transfer ,Astronomy and Astrophysics ,Atomic physics ,Branching (polymer chemistry) ,Atomic data - Abstract
Radiative lifetimes of 19 levels in Re I were measured using the time-resolved laser-induced fluorescence method. As far as we know, 15 results are reported for the first time. By combining the experimental lifetimes determined from the present work with theoretical branching fractions obtained by a pseudo-relativistic Hartree–Fock model including core-polarization contributions, a new set of semi-empirical transition probabilities and oscillator strengths for 47 Re I lines from 18 newly measured levels were derived.
- Published
- 2019
90. A three-dimensional indoor positioning technique based on visible light communication using chaotic particle swarm optimization algorithm
- Author
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Peng Qi, Canyu Xie, Weipeng Guan, Fangjie Li, Meiqi Zhang, Liu Xiaowei, and Yuxiang Wu
- Subjects
010302 applied physics ,Computer science ,Visible light communication ,Particle swarm optimization ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,010309 optics ,Indoor positioning system ,Chaotic particle swarm optimization ,0103 physical sciences ,Electrical and Electronic Engineering ,Algorithm ,Visible spectrum - Abstract
In this paper, an indoor visible light localization system based on improved chaotic particle swarm optimization (CPSO) is proposed to achieve indoor 3-D positioning. In the field of visible light positioning, most of the localization is two-dimensional positioning under the condition of height determined. In addition, some three-dimensional visible light localization systems use a hybrid algorithm that greatly improves the computational complexity of the system, or requires the user to first provide a better initial point for three-dimensional positioning, which can’t be applied to life well. In order to solve the problems in the field of VLP, this paper proposes an indoor visible light positioning system based on improved chaotic particle swarm optimization. In this paper, the chaos algorithm is firstly used in the visible light positioning area. Meanwhile, the proposed algorithm combines chaos algorithm and particle swarm optimization algorithm, and obtains a high positioning accuracy in the simulation space of 3 m × 3 m × 4m. Chaos optimization algorithm can make use of visible light indoor positioning system to achieve the positioning accuracy greatly, and join the particle swarm algorithm can offset the slow convergence of the chaos algorithm. The simulation results show that the visible light positioning system based on CPSO algorithm can achieve the average error of less than 1.4 cm, and the positioning accuracy of 96.6% sampling points can reach within 3.55 cm.
- Published
- 2018
91. Case-Based Model for Evaluating Coal Resources Mining Rights Under Mahalanobis Distance
- Author
-
Meiqi Zhang, Shaohui Zou, and Fuyao Xin
- Subjects
Mahalanobis distance ,Index (economics) ,business.industry ,Computer science ,020209 energy ,02 engineering and technology ,computer.software_genre ,Asset (computer security) ,Net present value ,Computer Science Applications ,Term (time) ,Set (abstract data type) ,Component (UML) ,0202 electrical engineering, electronic engineering, information engineering ,Coal ,Case-based reasoning ,Data mining ,Electrical and Electronic Engineering ,business ,computer - Abstract
Coal resources still play a significant role in the evolution of China’s energy structure in the long term. A set of scientific and reasonable evaluation models for coal resources mining rights (CRMR) is the guarantee to optimally develop and utilize Chinese coal resources. Artificial intelligence technology can increase the accuracy and efficiency of asset evaluation. Case-based reasoning (CBR) is the important component of artificial intelligence technology. Case similarity is critical to the CBR. Mahalanobis distance formula can describe properly case similarity when attribute strength function is unknown. Firstly, this paper reveals the mechanism of evaluating CRMR, and defines some important concepts such as attribute index, attribute strength function, underlying asset, case assets, and case similarity; secondly, a case-based model and a real option model for evaluating CRMR were set up. In addition, a real case of CRMR was used to study the application of case-based model and a real option model for evaluating CRMR. Comparing the differences among real option model for evaluating CRMR, the real option model, and net present value model, the results indicate that the price got by using the case-based model for evaluating CRMR is very close to the final bargain price, and case-based model for evaluating CRMR can raise the accuracy of CRMR evaluation.
- Published
- 2018
92. Synthesis of Highly Selective Magnetite (Fe3O4) and Tyrosinase Immobilized on Chitosan Microspheres as Low Potential Electrochemical Biosensor
- Author
-
Ying Wang, Jiaxin Liang, Hongquan Yang, Meiqi Zhang, Han Zhang, Jianhua Sun, Dankui Liao, Guangzhi Zhou, Muhammad Yaseen, Zhou Liqin, and Huan He
- Subjects
Renewable Energy, Sustainability and the Environment ,Tyrosinase ,010401 analytical chemistry ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Highly selective ,01 natural sciences ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,chemistry.chemical_compound ,chemistry ,Materials Chemistry ,Electrochemistry ,Electrochemical biosensor ,0210 nano-technology ,Magnetite ,Nuclear chemistry ,Chitosan microspheres - Published
- 2018
93. DFT calculation of square MoS2 nanotubes
- Author
-
Ichiro Yamane, Taro Nagahama, Mengting Weng, Takashi Yanase, Meiqi Zhang, Manami Goto, Takahiro Tamura, and Toshihiro Shimada
- Subjects
Nanotube ,Materials science ,Band gap ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,Molecular physics ,Atomic and Molecular Physics, and Optics ,Square (algebra) ,0104 chemical sciences ,Electronic, Optical and Magnetic Materials ,Condensed Matter::Materials Science ,chemistry.chemical_compound ,chemistry ,Zigzag ,Cylinder ,Edge states ,0210 nano-technology ,Chirality (chemistry) ,Molybdenum disulfide - Abstract
This paper present computational study on molybdenum disulfide (MoS2 ) nanotubes with square cross sections in order to elucidate the growth mechanism and properties of experimentally synthesized nanotubes. The results show that these square nanotubes have strain energies lower than the traditional cylinder ones in the small-diameter region. They also show a much smaller band gap and higher surface energies compared with the cylindrical ones. Zigzag and armchair chirality shows qualitatively different electronic structures about the localization of the edge states.
- Published
- 2021
94. Enzymatic degradability and release properties of graphene oxide/silk fibroin nanocomposite films
- Author
-
Zilong Ren, Xiafan Xu, Lin Ma, and Meiqi Zhang
- Subjects
chemistry.chemical_compound ,Nanocomposite ,Polymers and Plastics ,chemistry ,Chemical engineering ,Graphene ,law ,Materials Chemistry ,Oxide ,Fibroin ,General Chemistry ,Surfaces, Coatings and Films ,law.invention - Published
- 2021
95. Ladder-Type Dithienonaphthalene-Based Small-Molecule Acceptors for Efficient Nonfullerene Organic Solar Cells
- Author
-
Tao Wang, Jingming Xin, Meiqi Zhang, Yunlong Ma, Yu Yan, Qingdong Zheng, Wei Ma, and Changquan Tang
- Subjects
chemistry.chemical_classification ,Organic solar cell ,General Chemical Engineering ,Energy conversion efficiency ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Block (periodic table) ,Photochemistry ,01 natural sciences ,Small molecule ,0104 chemical sciences ,chemistry ,Materials Chemistry ,Charge carrier ,Absorption (chemistry) ,0210 nano-technology ,HOMO/LUMO ,Alkyl - Abstract
Two novel small molecule acceptors (DTNIC6 and DTNIC8) based on a ladder-type dithienonaphthalene (DTN) building block with linear (hexyl) or branched (2-ethylhexyl) alkyl substituents are designed and synthesized. Both acceptors exhibit strong and broad absorption in the range from 500 to 720 nm as well as appropriate highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) levels. Replacing the linear hexyl chains with the branched 2-ethylhexyl chains has a large impact on the film morphology of photoactive layers. In the blend film based on DTNIC8 bearing the branched alkyl chains, morphology with well-defined phase separation was observed. This optimal phase morphology yields efficient exciton dissociation, reduced bimolecular recombination, and enhanced and balanced charge carrier mobilities. Benefited from these factors, organic solar cells (OSCs) based on PBDB-T:DTNIC8 deliver a highest power conversion efficiency (PCE) of 9.03% with a high fill factor (FF) of 72.84%...
- Published
- 2017
96. Thrombolite reefs with archaeocyaths from the Xiannüdong Formation (Cambrian Series 2), Sichuan, China: implications for early Paleozoic bioconstruction
- Author
-
Dong-Jin Lee, Jongsun Hong, Meiqi Zhang, and Suk Joo Choh
- Subjects
010506 paleontology ,geography ,geography.geographical_feature_category ,biology ,Paleozoic ,Ecology ,Girvanella ,Thrombolite ,010502 geochemistry & geophysics ,biology.organism_classification ,01 natural sciences ,Paleontology ,Sponge ,Phanerozoic ,Ordovician ,General Earth and Planetary Sciences ,Cambrian Series 2 ,Reef ,Geology ,0105 earth and related environmental sciences ,General Environmental Science - Abstract
The early Cambrian incorporation of organisms with calcareous skeletons into microbial reefs initiated the metazoan bioconstructions of the Phanerozoic. Microbial reefs containing archaeocyaths from the middle early Cambrian Xiannudong Formation of the South China Block are investigated. The Xiannudong thrombolitic frameworks are composed primarily of Girvanella clumps and crusts, micritic clumps, and subordinate Epiphyton bundles. Amalgamated microbial frameworks contain sparse and rare (
- Published
- 2017
97. Development of quality indicators for non-small cell lung cancer care: a first step toward assessing and improving quality of cancer care in China
- Author
-
Han Bao, Xinyu Wang, Meina Liu, Jiaying Wang, Meiqi Zhang, Shouyi Li, Hao Jiang, Dan Liu, and Shaofei Su
- Subjects
China ,Cancer Research ,medicine.medical_specialty ,Lung Neoplasms ,media_common.quotation_subject ,Modified delphi ,Quality indicators ,lcsh:RC254-282 ,03 medical and health sciences ,0302 clinical medicine ,Carcinoma, Non-Small-Cell Lung ,Surveys and Questionnaires ,Health care ,Genetics ,Humans ,Medicine ,Quality (business) ,030212 general & internal medicine ,Lung cancer ,Quality Indicators, Health Care ,media_common ,Chinese health system ,business.industry ,Quality of care ,Cancer ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Clinical Practice ,Oncology ,Research Design ,030220 oncology & carcinogenesis ,Family medicine ,Non small cell ,business ,Research Article - Abstract
Background Large gap exists between clinical practice and recommended care and large room exists for the improvement of care quality for non-small cell lung cancer (NSCLC) in China. Results of some studies have shown that assessment of care quality can help to make improvement and the development of quality indicators is deemed as the initial and most essential part. Yet there is no such an indicators system specifically suitable for Chinese health care system. The goal of the study is to set up a group of Chinese quality indicators for NSCLC care and make it the first step towards the improvement of NSCLC care quality in China. Methods We constructed a new indicator framework based on the characteristics of NSCLC care and the nature of Chinese health care system. Under the new framework, potential indicators were collected and a 3-round modified Delphi process was conducted by a national multi-disciplinary Expert Panel to develop a set of indicators until they reached the final consensus. Results A new indicator framework (structure, process, communication, management of symptoms or treatment toxicity and outcome) was developed. Seventy four indicators were extracted from guidelines and relevant literatures as potential indicators; 43 indicators plus 1 suggested indicator were remained after the discussion of Round 1; questionnaires of Round 2 were rated by Expert Panel and 19 indicators met the inclusion criteria and entered Round 3; 2 of the eliminated indicators in Round 2 were retrieved by the Expert Panel at the in-person meeting (Round 3). Therefore, 21 indicators got the final consensus of the Expert Panel. Conclusions Guided by the new indicator structure, a set of indicators suitable for Chinese healthcare system was developed and can be utilized to measure and improve the care quality of non-small cell lung cancer. Electronic supplementary material The online version of this article (10.1186/s12885-017-3602-0) contains supplementary material, which is available to authorized users.
- Published
- 2017
98. The Effectiveness Of Physical Activity On Motor Skills In Children With Neurodevelopmental Disorders: A Meta-analysis
- Author
-
Meiqi Zhang and John Liu
- Subjects
medicine.medical_specialty ,Physical medicine and rehabilitation ,business.industry ,Meta-analysis ,Physical activity ,Medicine ,Physical Therapy, Sports Therapy and Rehabilitation ,Orthopedics and Sports Medicine ,business ,Motor skill - Published
- 2020
99. Skeletal fossils and microfacies analysis of the lowermost Cambrian in the southwestern margin of the North China Platform
- Author
-
Luoyang Li, Hao Yun, Meiqi Zhang, Wei Liu, and Xingliang Zhang
- Subjects
010506 paleontology ,Lithology ,Geology ,010502 geochemistry & geophysics ,01 natural sciences ,Sedimentary depositional environment ,Paleontology ,Sponge spicule ,Grainstone ,Ooid ,Siliciclastic ,Cambrian Series 2 ,Siltstone ,0105 earth and related environmental sciences ,Earth-Surface Processes - Abstract
The Xinji and Zhushadong formations are the oldest record of Cambrian deposits in the southwestern margin of the North China Platform. The two lithostratigraphic units are carbonate-dominated in lithology and are Cambrian Series 2 in age. The basal unit, the Xinji Formation yields diverse skeletal fossils, including sponge spicules, chancelloriid sclerites, hyoliths, micromolluscs, trilobites, echinoderm ossicles, cambroclaves, tianzhushanellids, protoconodonts and other small shelly fossils. The fossil assemblage, as the earliest fauna of the Cambrian in North China, provides an important window to investigate the Cambrian explosion in the region and contains fossil elements with biostratigraphical significance. Seven microfacies types of the Xinji and Zhushadong formations are recognized: (1) phosphorized and selectively dolomitized bioclastic grainstone, (2) dolomitized ooid grainstone, (3) dolomitized peloid wackstone, (4) lime mudstone preserved as dolomitic microsparite, (5) siliciclastic wackstone, (6) calcareous siltstone, and (7) breccia. The different microfacies are traced to three successive depositional environments, beginning with a bioclastic shoal, then a mixed-depositional back-shoal and finally an oolitic shoal. The system of the shoal and back-shoal is interpreted as representing the mixed siliciclastic-carbonate deposition during the initial transgression of the North China Platform as well as the early development of an epeiric environment.
- Published
- 2016
100. Facile construction of carbon nitride/cobalt ion/eosin Y nanohybrids for enhanced interaction and photocatalytic hydrogen production
- Author
-
Xuyuan Feng, Xiangqing Li, Lixia Qin, Meiqi Zhang, and Shi-Zhao Kang
- Subjects
Materials science ,Metal ions in aqueous solution ,Graphitic carbon nitride ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Photochemistry ,01 natural sciences ,Spectral line ,0104 chemical sciences ,law.invention ,chemistry.chemical_compound ,Colloid and Surface Chemistry ,chemistry ,law ,Photocatalysis ,0210 nano-technology ,Electron paramagnetic resonance ,Eosin Y ,Carbon nitride ,Hydrogen production - Abstract
The purpose of this work is to achieve a stable graphitic carbon nitride (g-C3N4)/cobalt ions/eosin Y nanohybrid with improved photocatalytic performance by interfacial implantation of cobalt ions. The interaction mechanism among components was explored in detail. The nanohybrid with optimal embedding of 5.0 wt.% cobalt ions showed about 18 times higher activity for H2 production than that of the g-C3N4, and also greater than the sum of g-C3N4/EY and g-C3N4/cobalt ions. It was denoted that there existed synergistic interaction between g-C3N4/cobalt ions and EY. Moreover, the obtained nanohybrid was more stable and active. The photocatalytic mechanism was further investigated by means of photoelectronic measurements, fluorescence spectra, and electron paramagnetic resonance spectra. It was found that, recombination of photogenerated charges was efficiently inhibited owing to strong interfacial interaction in the nanohybrid. It will offer a facile and low-cost way for fabricating other efficient heterogeneous photocatalyst by interfacial implantation of metal ions.
- Published
- 2021
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