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The article presents the case of Shirley Rassieur, who was mistakenly diagnosed with Alzheimer's disease. Two months after her death, after doctors had taken out her brain, sectioned it and subjected tissue to an antibody test and examined it under an electron microscope, they got back a different diagnosis: Rassieur died of Creutzfeldt-Jakob Disease, a rare and invariably fatal disease that kills by hollowing out the brain. INSET: A Mad Cow Cover-Up?.

The article focuses on Stephen Joyce, the grandson of author James Joyce. The grandson has the same physical features with that of James Joyce. His audacity and his pique have amused some fans of James Joyce. Over the years, the relationship between Stephen Joyce and the fans of James Joyce has gone from awkwardly symbiotic to plainly dysfunctional. In 1988, he took offense at the epilogue to Brenda Maddox's Nora, a biography of Joyce's wife, which described the decades that Joyce's schizophrenic daughter, Lucia, spent in a mental asylum.

The article reports on South African taxidermist Reinhold Rau's quagga breeding project. The quagga is a horse-like animal, stripped like a zebra in the front but stripeless in the hind quarters with some brown markings. The animal has been extinct since 1883, but Rau is attempting to breed it back into existence by mating zebras with quagga characteristics.

Discusses the evolution of United States President George W. Bush's address to Congress in the wake of the September 11, 2001 terrorist attacks. Weakness of prior speeches; Details of Bush's speech preparation; Work of his speechwriting team, led by Michael Gerson; Etymology of words used in speech; Need for caution in word choice; Emphasis of reason over wrath in U.S. retaliation; Public opinion of the speech.

The article explores a search for Small Sloops, a type of sailboat built mostly by a single Center Moriches boatmaker from 1908 to 1932, undertaken by Cherry Provost of Glen Ridge, New Jersey. About a hundred and fifty of the boats were made and were given to their children by the families of local gentry. Sloops' memories are discussed in great detail, including a 1954 Hurricane.

The article discusses collaboration between musicians Paul Gemignani and Alex Gemignani and composer Stephen Sondheim. Topics include their work on the musical "Merrily," Paul Gemignani's work with the musical "Kiss Me, Kate" in relation to the song "Where Is the Life That Late I Led," and Sondheim's opinion on jazz singer Cyrille Aimée.

The article offers information on Broadway composer Stephen Sondheim who will receive the PEN/Allen Foundation Literary Service Award at the 2017 PEN America Literary Gala on April 25 at the American Museum of Natural History in New York. It mentions that performance of Meryl Streep in the film adaptation of Sondheim's musical Into the Woods, who will also receive the prize.

This article focuses on the use of prion theory to explain prion disease. The case of a woman who died from the prion disease is detailed. Prion is described as a misshaped protein that causes nearby proteins to copy its shape. The two forms of the prion protein are described. A brief background about the mad cow disease outbreak in Europe is presented.

The article presents a report on attempts to find benefits from global warming. British farmers do not have to spend as much money on feed, as their animals can graze longer. Dutch architects are designing floating houses and businesses in preparation for a flooded country. The biggest profiteer may by Pat Broe, an investor who paid $7 for the port of Churchill on Hudson Bay, which may soon be used for shipping when the top of the globe becomes easily navigable.

A letter to the editor is presented in response to an article on author David Foster Wallace's writing, by Geoff Dyer, in the April 2011 issue.

The article discusses smiling styles particular to nations. The American smile bares only the top teeth while the English smile reveals both the top and bottom teeth, making the smiler look defensive. Psychology professor Dacher Keltner is able to predict with accuracy the nationality of a mouth by the type of smile it is making.

Presents a mini-encyclopedia of the most noteworthy ideas of the previous 12 months. Acoustic keyboard eavesdropping; "Acting White" myth; Augmented bar codes; Cars that emote; Concrete you can see through; Criminalizing reckless sex; Employable liberal arts majors; Eyeball jewelry; Giga-waves; Others.