51. Validation of the Italian version of the PSP Quality of Life questionnaire
- Author
-
Francesca Di Biasio, Alessandra Nicoletti, Alessandro Padovani, Anna Vera Milner, Mario Zappia, Nicola Modugno, Brigida Minafra, Luca Magistrelli, Marina Picillo, Sebastiano Galantucci, Enrica Olivola, Paolo Barone, Fabio Bruschi, Roberta Marchese, Rosa De Micco, Maurizio Zibetti, Sofia Cuoco, Nicola Biagio Mercuri, Roberta Zangaglia, Maria Cristina Rizzetti, Alessio Di Fonzo, Immacolata Carotenuto, Francesco Paolo Bonifacio, Maria Chiara Malaguti, Giulia Lazzeri, Daniela Frosini, Andrea Pilotto, Marianna Amboni, Giulia Franco, Eleonora Del Prete, Alessandro Tessitore, Tommaso Schirinzi, Margherita Fabbri, Alessandro Stefani, Francesca Elifani, Barbara Borroni, Anna De Rosa, Maria Antonietta Volontè, Roberto Ceravolo, Marika Falla, Cristina Rascunà, Roberto Erro, Gabriella Santangelo, Picillo, Marina, Cuoco, Sofia, Amboni, Marianna, Bonifacio, Francesco Paolo, Bruschi, Fabio, Carotenuto, Immacolata, De Micco, Rosa, De Rosa, Anna, Del Prete, Eleonora, Di Biasio, Francesca, Elifani, Francesca, Erro, Roberto, Fabbri, Margherita, Falla, Marika, Franco, Giulia, Frosini, Daniela, Galantucci, Sebastiano, Lazzeri, Giulia, Magistrelli, Luca, Malaguti, Maria Chiara, Milner, Anna Vera, Minafra, Brigida, Olivola, Enrica, Pilotto, Andrea, Rascunà, Cristina, Rizzetti, Maria Cristina, Schirinzi, Tommaso, Borroni, Barbara, Ceravolo, Roberto, Di Fonzo, Alessio, Marchese, Roberta, Mercuri, Nicola B, Modugno, Nicola, Nicoletti, Alessandra, Padovani, Alessandro, Santangelo, Gabriella, Stefani, Alessandro, Tessitore, Alessandro, Volontè, Maria Antonietta, Zangaglia, Roberta, Zappia, Mario, Zibetti, Maurizio, Barone, Paolo, Picillo, M., Cuoco, S., Amboni, M., Bonifacio, F. P., Bruschi, F., Carotenuto, I., De Micco, R., De Rosa, A., Del Prete, E., Di Biasio, F., Elifani, F., Erro, R., Fabbri, M., Falla, M., Franco, G., Frosini, D., Galantucci, S., Lazzeri, G., Magistrelli, L., Malaguti, M. C., Milner, A. V., Minafra, B., Olivola, E., Pilotto, A., Rascuna, C., Rizzetti, M. C., Schirinzi, T., Borroni, B., Ceravolo, R., Di Fonzo, A., Marchese, R., Mercuri, N. B., Modugno, N., Nicoletti, A., Padovani, A., Santangelo, G., Stefani, A., Tessitore, A., Volonte, M. A., Zangaglia, R., Zappia, M., Zibetti, M., and Barone, P.
- Subjects
Male ,medicine.medical_specialty ,Neurology ,Movement disorders ,Psychometrics ,Psychological intervention ,Dermatology ,Disease ,Parkinsonism ,Settore MED/26 ,03 medical and health sciences ,0302 clinical medicine ,Clinical trials ,Progressive supranuclear palsy ,Quality of life ,Cronbach's alpha ,Progressive ,80 and over ,Medicine ,Supranuclear Palsy ,Humans ,030212 general & internal medicine ,Aged ,Aged, 80 and over ,business.industry ,Reproducibility of Results ,General Medicine ,medicine.disease ,Female ,Italy ,Self Report ,Supranuclear Palsy, Progressive ,Quality of Life ,humanities ,eye diseases ,Clinical trial ,Psychiatry and Mental health ,Convergent validity ,Physical therapy ,Neurology (clinical) ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Background: Progressive supranuclear palsy (PSP) is a rare rapidly progressive, neurodegenerative disease characterized by falls and ocular movement disturbances. The use of health-related quality of life (HR-QoL) measures allows assessing changes in health status induced by therapeutic interventions or disease progress in neurodegenerative diseases. The PSP-QoL is a 45-item, self-administered questionnaire designed to evaluate HR-QoL in PSP. Methods and Results: Here, the PSP-QoL was translated into Italian and validated in 190 PSP (96 women and 94 men; mean age ± standard deviation, 72 ± 6.5; mean disease duration, 4.2 ± 2.3) patients diagnosed according to the Movement Disorder Society criteria and recruited in 16 third level movement disorders centers participating in the Neurecanet project. The mean PSP-QoL total score was 77.8 ± 37 (physical subscore, 46.5 ± 18.7; mental subscore, 33.6 ± 19.2). The internal consistency was high (Cronbach’s alpha = 0.954); corrected item-total correlation was > 0.40 for the majority of items. The significant and moderate correlation of the PSP-QoL with other HR-QoL measures as well as with motor and disability assessments indicated adequate convergent validity of the scale. Gender and geographic location presented a significant impact on the PSP-QoL in our sample with women and patients from the South of Italy scoring higher than their counterparts. Conclusion: In conclusion, the Italian version of the PSP-QoL is an easy, reliable and valid tool for assessment of HR-QoL in PSP.
- Published
- 2019