213 results on '"Lubbe, S"'
Search Results
52. Transitiepad 'Bioraffinage'
- Author
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Elbersen, H. W., Sanders, J. P. M., Dam, J. E. G., Earl Goetheer, Boerrigter, H., Ree, R., Papenhuijzen, H., Sengers, H. H. W. J. M., Meeusen-Van Onna, M. J. G., Kramer, K. J., Smit, A. B., Heeres, E., Lubbe, S., Haan, A., Seshan, K., and Welink, J. H.
- Subjects
Wageningen Economic Research ,LEI Sector & Ondernemerschap ,LEI Consumer & behaviour ,LEI Consument en Gedrag (CONS & GEDRAG) ,AFSG Biobased Products ,Biobased Chemistry and Technology ,LEI Consument and Behaviour ,Life Science ,LEI Markt en Ketens ,LEI Consument & Gedrag ,LEI Agricultural sector & entrepreneurship - Published
- 2003
53. Cumulative impact of common genetic variants and other risk factors on colorectal cancer risk in 42 103 individuals
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Dunlop, MG, Tenesa, A, Farrington, SM, Ballereau, S, Brewster, DH, Koessler, T, Pharoah, P, Schafmayer, C, Hampe, J, Voelzke, H, Chang-Claude, J, Hoffmeister, M, Brenner, H, von Holst, S, Picelli, S, Lindblom, A, Jenkins, MA, Hopper, JL, Casey, G, Duggan, D, Newcomb, PA, Abuli, A, Bessa, X, Ruiz-Ponte, C, Castellvi-Bel, S, Niittymaeki, I, Tuupanen, S, Karhu, A, Aaltonen, L, Zanke, B, Hudson, T, Gallinger, S, Barclay, E, Martin, L, Gorman, M, Carvajal-Carmona, L, Walther, A, Kerr, D, Lubbe, S, Broderick, P, Chandler, I, Pittman, A, Penegar, S, Campbell, H, Tomlinson, I, Houlston, RS, Dunlop, MG, Tenesa, A, Farrington, SM, Ballereau, S, Brewster, DH, Koessler, T, Pharoah, P, Schafmayer, C, Hampe, J, Voelzke, H, Chang-Claude, J, Hoffmeister, M, Brenner, H, von Holst, S, Picelli, S, Lindblom, A, Jenkins, MA, Hopper, JL, Casey, G, Duggan, D, Newcomb, PA, Abuli, A, Bessa, X, Ruiz-Ponte, C, Castellvi-Bel, S, Niittymaeki, I, Tuupanen, S, Karhu, A, Aaltonen, L, Zanke, B, Hudson, T, Gallinger, S, Barclay, E, Martin, L, Gorman, M, Carvajal-Carmona, L, Walther, A, Kerr, D, Lubbe, S, Broderick, P, Chandler, I, Pittman, A, Penegar, S, Campbell, H, Tomlinson, I, and Houlston, RS
- Abstract
OBJECTIVE: Colorectal cancer (CRC) has a substantial heritable component. Common genetic variation has been shown to contribute to CRC risk. A study was conducted in a large multi-population study to assess the feasibility of CRC risk prediction using common genetic variant data combined with other risk factors. A risk prediction model was built and applied to the Scottish population using available data. DESIGN: Nine populations of European descent were studied to develop and validate CRC risk prediction models. Binary logistic regression was used to assess the combined effect of age, gender, family history (FH) and genotypes at 10 susceptibility loci that individually only modestly influence CRC risk. Risk models were generated from case-control data incorporating genotypes alone (n=39,266) and in combination with gender, age and FH (n=11,324). Model discriminatory performance was assessed using 10-fold internal cross-validation and externally using 4187 independent samples. The 10-year absolute risk was estimated by modelling genotype and FH with age- and gender-specific population risks. RESULTS: The median number of risk alleles was greater in cases than controls (10 vs 9, p<2.2 × 10(-16)), confirmed in external validation sets (Sweden p=1.2 × 10(-6), Finland p=2 × 10(-5)). The mean per-allele increase in risk was 9% (OR 1.09; 95% CI 1.05 to 1.13). Discriminative performance was poor across the risk spectrum (area under curve for genotypes alone 0.57; area under curve for genotype/age/gender/FH 0.59). However, modelling genotype data, FH, age and gender with Scottish population data shows the practicalities of identifying a subgroup with >5% predicted 10-year absolute risk. CONCLUSION: Genotype data provide additional information that complements age, gender and FH as risk factors, but individualised genetic risk prediction is not currently feasible. Nonetheless, the modelling exercise suggests public health potential since it is possible to stratify the popula
- Published
- 2013
54. Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk
- Author
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Dunlop, MG, Dobbins, SE, Farrington, SM, Jones, AM, Palles, C, Whiffin, N, Tenesa, A, Spain, S, Broderick, P, Ooi, L-Y, Domingo, E, Smillie, C, Henrion, M, Frampton, M, Martin, L, Grimes, G, Gorman, M, Semple, C, Ma, YP, Barclay, E, Prendergast, J, Cazier, J-B, Olver, B, Penegar, S, Lubbe, S, Chander, I, Carvajal-Carmona, LG, Ballereau, S, Lloyd, A, Vijayakrishnan, J, Zgaga, L, Rudan, I, Theodoratou, E, Starr, JM, Deary, I, Kirac, I, Kovacevic, D, Aaltonen, LA, Renkonen-Sinisalo, L, Mecklin, J-P, Matsuda, K, Nakamura, Y, Okada, Y, Gallinger, S, Duggan, DJ, Conti, D, Newcomb, P, Hopper, J, Jenkins, MA, Schumacher, F, Casey, G, Easton, D, Shah, M, Pharoah, P, Lindblom, A, Liu, T, Smith, CG, West, H, Cheadle, JP, Midgley, R, Kerr, DJ, Campbell, H, Tomlinson, IP, Houlston, RS, Dunlop, MG, Dobbins, SE, Farrington, SM, Jones, AM, Palles, C, Whiffin, N, Tenesa, A, Spain, S, Broderick, P, Ooi, L-Y, Domingo, E, Smillie, C, Henrion, M, Frampton, M, Martin, L, Grimes, G, Gorman, M, Semple, C, Ma, YP, Barclay, E, Prendergast, J, Cazier, J-B, Olver, B, Penegar, S, Lubbe, S, Chander, I, Carvajal-Carmona, LG, Ballereau, S, Lloyd, A, Vijayakrishnan, J, Zgaga, L, Rudan, I, Theodoratou, E, Starr, JM, Deary, I, Kirac, I, Kovacevic, D, Aaltonen, LA, Renkonen-Sinisalo, L, Mecklin, J-P, Matsuda, K, Nakamura, Y, Okada, Y, Gallinger, S, Duggan, DJ, Conti, D, Newcomb, P, Hopper, J, Jenkins, MA, Schumacher, F, Casey, G, Easton, D, Shah, M, Pharoah, P, Lindblom, A, Liu, T, Smith, CG, West, H, Cheadle, JP, Midgley, R, Kerr, DJ, Campbell, H, Tomlinson, IP, and Houlston, RS
- Abstract
We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10(-10)), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10(-10)) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10(-10)) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC.
- Published
- 2012
55. Multiple Common Susceptibility Variants near BMP Pathway Loci GREM1, BMP4, and BMP2 Explain Part of the Missing Heritability of Colorectal Cancer
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Gibson, G, Tomlinson, IPM, Carvajal-Carmona, LG, Dobbins, SE, Tenesa, A, Jones, AM, Howarth, K, Palles, C, Broderick, P, Jaeger, EEM, Farrington, S, Lewis, A, Prendergast, JGD, Pittman, AM, Theodoratou, E, Olver, B, Walker, M, Penegar, S, Barclay, E, Whiffin, N, Martin, L, Ballereau, S, Lloyd, A, Gorman, M, Lubbe, S, Howie, B, Marchini, J, Ruiz-Ponte, C, Fernandez-Rozadilla, C, Castells, A, Carracedo, A, Castellvi-Bel, S, Duggan, D, Conti, D, Cazier, J-B, Campbell, H, Sieber, O, Lipton, L, Gibbs, P, Martin, NG, Montgomery, GW, Young, J, Baird, PN, Gallinger, S, Newcomb, P, Hopper, J, Jenkins, MA, Aaltonen, LA, Kerr, DJ, Cheadle, J, Pharoah, P, Casey, G, Houlston, RS, Dunlop, MG, Gibson, G, Tomlinson, IPM, Carvajal-Carmona, LG, Dobbins, SE, Tenesa, A, Jones, AM, Howarth, K, Palles, C, Broderick, P, Jaeger, EEM, Farrington, S, Lewis, A, Prendergast, JGD, Pittman, AM, Theodoratou, E, Olver, B, Walker, M, Penegar, S, Barclay, E, Whiffin, N, Martin, L, Ballereau, S, Lloyd, A, Gorman, M, Lubbe, S, Howie, B, Marchini, J, Ruiz-Ponte, C, Fernandez-Rozadilla, C, Castells, A, Carracedo, A, Castellvi-Bel, S, Duggan, D, Conti, D, Cazier, J-B, Campbell, H, Sieber, O, Lipton, L, Gibbs, P, Martin, NG, Montgomery, GW, Young, J, Baird, PN, Gallinger, S, Newcomb, P, Hopper, J, Jenkins, MA, Aaltonen, LA, Kerr, DJ, Cheadle, J, Pharoah, P, Casey, G, Houlston, RS, and Dunlop, MG
- Abstract
Genome-wide association studies (GWAS) have identified 14 tagging single nucleotide polymorphisms (tagSNPs) that are associated with the risk of colorectal cancer (CRC), and several of these tagSNPs are near bone morphogenetic protein (BMP) pathway loci. The penalty of multiple testing implicit in GWAS increases the attraction of complementary approaches for disease gene discovery, including candidate gene- or pathway-based analyses. The strongest candidate loci for additional predisposition SNPs are arguably those already known both to have functional relevance and to be involved in disease risk. To investigate this proposition, we searched for novel CRC susceptibility variants close to the BMP pathway genes GREM1 (15q13.3), BMP4 (14q22.2), and BMP2 (20p12.3) using sample sets totalling 24,910 CRC cases and 26,275 controls. We identified new, independent CRC predisposition SNPs close to BMP4 (rs1957636, P = 3.93×10(-10)) and BMP2 (rs4813802, P = 4.65×10(-11)). Near GREM1, we found using fine-mapping that the previously-identified association between tagSNP rs4779584 and CRC actually resulted from two independent signals represented by rs16969681 (P = 5.33×10(-8)) and rs11632715 (P = 2.30×10(-10)). As low-penetrance predisposition variants become harder to identify-owing to small effect sizes and/or low risk allele frequencies-approaches based on informed candidate gene selection may become increasingly attractive. Our data emphasise that genetic fine-mapping studies can deconvolute associations that have arisen owing to independent correlation of a tagSNP with more than one functional SNP, thus explaining some of the apparently missing heritability of common diseases.
- Published
- 2011
56. Ravenvennen uitgeroepen tot libellenreservaat
- Author
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Lubbe, S. van der, Veling, K., Lubbe, S. van der, and Veling, K.
- Abstract
De Ravenvennen is een natuurgebied in beheer van het Limburgs landschap. Er komen veel soorten libellen voor, men heeft aandacht voor libellen in het beheer, en het is goed toegankelijk. Genoeg redenen voor De Vlinderstichting om het gebied uit te roepen tot libellenreservaat.
- Published
- 2011
57. A large-scale meta-analysis to refine colorectal cancer risk estimates associated with MUTYH variants
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Theodoratou, E, Campbell, H, Tenesa, A, Houlston, R, Webb, E, Lubbe, S, Broderick, P, Gallinger, S, Croitoru, EM, Jenkins, MA, Win, AK, Cleary, SP, Koessler, T, Pharoah, PD, Kuery, S, Bezieau, S, Buecher, B, Ellis, NA, Peterlongo, P, Offit, K, Aaltonen, LA, Enholm, S, Lindblom, A, Zhou, X-L, Tomlinson, IP, Moreno, V, Blanco, I, Capella, G, Barnetson, R, Porteous, ME, Dunlop, MG, Farrington, SM, Theodoratou, E, Campbell, H, Tenesa, A, Houlston, R, Webb, E, Lubbe, S, Broderick, P, Gallinger, S, Croitoru, EM, Jenkins, MA, Win, AK, Cleary, SP, Koessler, T, Pharoah, PD, Kuery, S, Bezieau, S, Buecher, B, Ellis, NA, Peterlongo, P, Offit, K, Aaltonen, LA, Enholm, S, Lindblom, A, Zhou, X-L, Tomlinson, IP, Moreno, V, Blanco, I, Capella, G, Barnetson, R, Porteous, ME, Dunlop, MG, and Farrington, SM
- Abstract
BACKGROUND: defective DNA repair has a causal role in hereditary colorectal cancer (CRC). Defects in the base excision repair gene MUTYH are responsible for MUTYH-associated polyposis and CRC predisposition as an autosomal recessive trait. Numerous reports have suggested MUTYH mono-allelic variants to be low penetrance risk alleles. We report a large collaborative meta-analysis to assess and refine CRC risk estimates associated with bi-allelic and mono-allelic MUTYH variants and investigate age and sex influence on risk. METHODS: MUTYH genotype data were included from 20 565 cases and 15 524 controls. Three logistic regression models were tested: a crude model; adjusted for age and sex; adjusted for age, sex and study. RESULTS: all three models produced very similar results. MUTYH bi-allelic carriers demonstrated a 28-fold increase in risk (95% confidence interval (CI): 6.95-115). Significant bi-allelic effects were also observed for G396D and Y179C/G396D compound heterozygotes and a marginal mono-allelic effect for variant Y179C (odds ratio (OR)=1.34; 95% CI: 1.00-1.80). A pooled meta-analysis of all published and unpublished datasets submitted showed bi-allelic effects for MUTYH, G396D and Y179C (OR=10.8, 95% CI: 5.02-23.2; OR=6.47, 95% CI: 2.33-18.0; OR=3.35, 95% CI: 1.14-9.89) and marginal mono-allelic effect for variants MUTYH (OR=1.16, 95% CI: 1.00-1.34) and Y179C alone (OR=1.34, 95% CI: 1.01-1.77). CONCLUSIONS: overall, this large study refines estimates of disease risk associated with mono-allelic and bi-allelic MUTYH carriers.
- Published
- 2010
58. The 14q22.2 colorectal cancer variant rs4444235 shows cis-acting regulation of BMP4
- Author
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Lubbe, S J, primary, Pittman, A M, additional, Olver, B, additional, Lloyd, A, additional, Vijayakrishnan, J, additional, Naranjo, S, additional, Dobbins, S, additional, Broderick, P, additional, Gómez-Skarmeta, J L, additional, and Houlston, R S, additional
- Published
- 2011
- Full Text
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59. Comprehensive Evaluation of the Impact of 14 Genetic Variants on Colorectal Cancer Phenotype and Risk
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Lubbe, S. J., primary, Di Bernardo, M. C., additional, Broderick, P., additional, Chandler, I., additional, and Houlston, R. S., additional
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- 2011
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60. MLH1-93G > A is a risk factor for MSI colorectal cancer
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Whiffin, N., primary, Broderick, P., additional, Lubbe, S. J., additional, Pittman, A. M., additional, Penegar, S., additional, Chandler, I., additional, and Houlston, R. S., additional
- Published
- 2011
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61. Transitiepad 'Bioraffinage'
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Elbersen, H.W., Sanders, J.P.M., van Dam, J.E.G., Goetheer, E., Boerrigter, H., van Ree, R., Papenhuijzen, H., Sengers, H.H.W.J.M., Meeusen-van Onna, M.J.G., Kramer, K.J., Smit, A.B., Heeres, E., van der Lubbe, S., de Haan, A., Seshan, K., Welink, J.H., Elbersen, H.W., Sanders, J.P.M., van Dam, J.E.G., Goetheer, E., Boerrigter, H., van Ree, R., Papenhuijzen, H., Sengers, H.H.W.J.M., Meeusen-van Onna, M.J.G., Kramer, K.J., Smit, A.B., Heeres, E., van der Lubbe, S., de Haan, A., Seshan, K., and Welink, J.H.
- Published
- 2003
62. The pulp and paper properties ofSirex noctilioinfested and fire-damagedthermomechanically pulped, South African grownPinus patula
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du Plessis, M, primary, le Roux, N J, additional, Gardner-Lubbe, S, additional, Swart, J PJ, additional, and Rypstra, T, additional
- Published
- 2010
- Full Text
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63. A large-scale meta-analysis to refine colorectal cancer risk estimates associated with MUTYH variants
- Author
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Theodoratou, E, primary, Campbell, H, additional, Tenesa, A, additional, Houlston, R, additional, Webb, E, additional, Lubbe, S, additional, Broderick, P, additional, Gallinger, S, additional, Croitoru, E M, additional, Jenkins, M A, additional, Win, A K, additional, Cleary, S P, additional, Koessler, T, additional, Pharoah, P D, additional, Küry, S, additional, Bézieau, S, additional, Buecher, B, additional, Ellis, N A, additional, Peterlongo, P, additional, Offit, K, additional, Aaltonen, L A, additional, Enholm, S, additional, Lindblom, A, additional, Zhou, X-L, additional, Tomlinson, I P, additional, Moreno, V, additional, Blanco, I, additional, Capellà, G, additional, Barnetson, R, additional, Porteous, M E, additional, Dunlop, M G, additional, and Farrington, S M, additional
- Published
- 2010
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64. Biplot methodology in exploratory analysis of microarray data
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Gardner-Lubbe, S., primary, le Roux, N. J., additional, Maunders, H., additional, Shah, V., additional, and Patwardhan, S., additional
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- 2009
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65. The effect ofSirex noctilioinfestation and fire damage on the chemical composition of South African-grownPinus patulapulpwood
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du Plessis, M, primary, le Roux, NJ, additional, Gardner-Lubbe, S, additional, Swart (Change Le to le), JPJ, additional, and Rypstra, T, additional
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- 2008
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66. Comprehensive analysis of common mitochondrial DNA variants and colorectal cancer risk
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Webb, E, primary, Broderick, P, additional, Chandler, I, additional, Lubbe, S, additional, Penegar, S, additional, Tomlinson, I P M, additional, and Houlston, R S, additional
- Published
- 2008
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67. Microsatellite instability indicative of defects in the major mismatch repair genes is rare in patients with B-cell chronic lymphocytic leukemia: Evaluation with disease stage and family history
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Sellick, G. S., primary, Lubbe, S. J., additional, Matutes, E., additional, Catovsky, D., additional, and Houlston, R. S., additional
- Published
- 2007
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68. Preliminaries into problems to access information – the digital divide and rural communities
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Sikhakhane, B., primary and Lubbe, S., additional
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- 2005
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69. Management information searching for decision making
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Lubbe, S., primary
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- 2004
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70. Software piracy – Some aspects for South African managers to keep in mind
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De Kock, D, primary, Lubbe, S, additional, and Kritzinger, W, additional
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- 2003
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71. Development of a case study methodology in the information technology (IT) field in South Africa: a step-by-step approach
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Lubbe, S., primary
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- 2003
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72. Clinical educators' self-reported personal and professional development after completing a short course in undergraduate clinical supervision at Stellenbosch University.
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Schmutz, A. M. S., Gardner-Lubbe, S., and Archer, E.
- Subjects
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CLINICAL supervision , *UNDERGRADUATES , *CLINICAL competence , *CAREER development , *MEDICAL teaching personnel , *MEDICAL education - Abstract
Background. In 2007, a Supervision Course in Undergraduate Clinical Supervision was developed at the Faculty of Medicine and Health Sciences at Stellenbosch University in South Africa. The target group was inter-professional clinical educators that are involved in student education on the clinical platform. Although the course participants were professionals and specialists in their own fields, the majority of clinical educators have very little or no knowledge of adult education. The Supervision Course aims to develop clinical supervision skills of clinical educators by exposing these supervisors to basic principles of education and specifically clinical teaching, resulting in quality education for undergraduate students. The aim of this study was to determine the impact of this short course on the personal and professional growth of the clinical educator. Methods. A qualitative study was performed, including an open-ended questionnaire that provided opportunity for the clinical educators to elaborate freely on their strengths, weaknesses and areas of desired improvement before and after the Supervision Course, and a semi-structured individual interview after the Supervision Course. The questionnaire data were categorised according to strengths, weaknesses and areas of desired improvement. An inductive approach was used to analyse the qualitative data. Key themes that emerged from the interviews were identified and grouped together in categories. Results. The results are summarised in table format to identify themes with supporting quotes. Conclusion. Although a small sample, this study demonstrates the personal and professional growth reported by attendees of a clinical supervision short course. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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73. The pulp and paper properties of Sirex noctilio infested and fire-damagedthermomechanically pulped, South African grown Pinus patula.
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du Plessis, M., le Roux, N. J., Gardner-Lubbe, S., Swart, J. P. J., and Rypstra, T.
- Subjects
SIREX noctilio ,SIREX ,PULPING ,PINUS patula ,PINE - Abstract
Pinus patula is the softwood species most extensively planted in South Africa. However, large portions of these plantings are under threat from Sirex noctilio infestation and occasional forest fires. In this exploratory investigation, the effects of tree age, Sirex noctilio infestation and fire damage to wood from Pinus patula trees on their pulp and paper properties were evaluated. Pulp was produced using the thermomechanical pulping (TMP) process. The energy consumption required to pulp the different pulpwood materials was determined. Pulps were beaten for five different time periods to investigate the development of the fibre properties in response to increasing energy input. Paper properties such as burst, tear strength and breaking length were determined on handsheets manufactured from unbeaten and beaten pulps. Box and line plots and canonical variate analysis biplots were used to statistically analyse the data. It was found that the burst strength of paper produced from healthy trees was significantly higher than that from sirex-infested or fire damaged (burnt) trees. Similarly, the tear strength of paper from healthy and burnt trees was significantly better than from sirex-infested or young trees. No significant differences in breaking length were evident between the pulpwood materials and an increase in beating time did not lead to any improvements. From this study it can be concluded that wood from dead or dying, sirex-infested and young trees produced paper with consistently lower strength properties compared to wood obtained from healthy 12-year-old trees. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
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74. The effect of Sirex noctilio infestation and fire damage on the chemical composition of South African-grown Pinus patula pulpwood.
- Author
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du Plessis, M., le Roux, N. J., Gardner-Lubbe, S., Swart, J. P. J., and Rypstra, T.
- Subjects
SIREX noctilio ,XIPHYDRIIDAE ,AMYLOSTEREUM ,TREE mortality ,AGRICULTURAL education - Abstract
The infection and association between the wood wasp Sirex noctilio and the fungus Amylostereum areolatum is responsible for large-scale tree mortality in the Midlands of the KwaZulu-Natal province in South Africa. An exploratory investigation on the effect of the infestation of trees by the wood wasp and its associated fungus on the chemical composition of Pinus patula pulpwood was undertaken. Various tree classes representing different levels of physiological growth stress from this infestation were compared. Together with the above stress agents, fire damage to P. patula trees was also considered as a possible cause of changes in pulpwood chemical composition. Chemical analyses to determine the Seifert cellulose and Klason lignin contents as well as the levels of water- and solvent-soluble extractives were conducted using published Tappi standard methods. The results indicated only negligible differences between infestation levels (tree classes) with respect to Seifert cellulose and Klason lignin contents. In contrast, highly significant differences were observed for solvent- and water-borne extractives. It is evident from the results that P. patula trees engage a defence strategy to counter the effects of the infestation and the resulting physiological stress. The results of the chemical analyses suggest that trees should not be harvested any younger than the intended rotation age of 12 years and at the time of harvesting all the biomass, including the infected wood, should be sent to the pulp mill. Fire-damaged trees can be utilised in the same way as healthy trees when applying the TMP process provided the charcoal on the outer bark is removed. The usefulness of a biplot to simultaneously display the various tree classes and their chemical composition is illustrated. [ABSTRACT FROM AUTHOR]
- Published
- 2008
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75. Parkinson's disease in GTP cyclohydrolase-1 mutation carriers
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Mencacci, N. E., Isaias, I. U., Reich, M. M., Ganos, C., Plagnol, V., Polke, J. M., Bras, J., Stamelou, M., Noyce, A. J., Opladen, T., Muenchau, A., Hodecker, S., Volkmann, J., Lees, A., Alegria, P., Lesage, S., Cormier, F., Alexis Brice, Heutink, P., Gasser, T., Pittman, A., Lubbe, S., Morris, H. R., Singleton, A., Hardy, J., Klebe, S., Bhatia, K. P., and Wood, N. W.
76. An assessment of information access in magogoe village, nw province, South Africa
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Mahole, T., Lubbe, S., Meyer, J., and Nehemiah Mavetera
77. Deletions at 22q11.2 in idiopathic Parkinson's disease: A combined analysis of GWAS data
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Mok, K. Y., Sheerin, U., Simon-Sanchez, J., Salaka, A., Chester, L., Escott-Price, V., Mantripragada, K., Doherty, K. M., Noyce, A. J., Mencacci, N. E., Lubbe, S. J., Williams-Gray, C. H., Barker, R. A., Dijk, K. D., Berendse, H. W., Heutink, P., Corvol, J. -C, Cormier, F., Lesage, S., Alexis Brice, Brockmann, K., Schulte, C., Gasser, T., Foltynie, T., Limousin, P., Morrison, K. E., Clarke, C. E., Sawcer, S., Warner, T. T., Lees, A. J., Morris, H. R., Nalls, M. A., Singleton, A. B., Hardy, J., Abramov, A. Y., Plagnol, V., Williams, N. M., and Wood, N. W.
78. From conception to demise: Implications for users of information systems in changing a parastatal in kwaZulu-Natal, South Africa
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Lubbe, S., Shawren Singh, and Hall, G.
79. Frequency and Phenoptypic Spectrum of KMT2B Mutations in Childhood-Onset Dystonia: Results from a Single-Centre Cohort Study
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Carecchio, M., Zorzi, G., Invernizzi, F., Panteghini, C., Luigi Romito, Zibordi, F., Leuzzi, V., Galosi, S., Morana, P., Morana, B., Piano, C., Bentivoglio, A., Reale, C., Girotti, F., Topf, M., Joseph, A., Kurian, M., Lubbe, S., Garavaglia, B., Mencacci, N., and Nardocci, N.
80. An investigation into the effectiveness of ICT supported learning system usage in South African tertiary institutions
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Peter Mkhize and Lubbe, S.
81. Towards a hypothetical e-Government solution: A South African perspective
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Shawren Singh, Lubbe, S., Naidoo, G., and Klopper, R.
82. A genome-wide scan of 10 000 gene-centric variants and colorectal cancer risk
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Webb E, Broderick P, Lubbe S, Chandler I, Tomlinson I, and Richard Houlston
83. An analysis of collaborative learning as a prevalent in-structional strategy of South Africa Government eLearning practices
- Author
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Peter Mkhize, Huisman, M., and Lubbe, S.
84. Fault diagnosis in multivariate statistical process monitoring
- Author
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Mostert, Andre George, Lubbe, S, and Coetzer, R L J
- Subjects
Statistical Sciences - Abstract
The application of multivariate statistical process monitoring (MSPM) methods has gained considerable momentum over the last couple of decades, especially in the processing industry for achieving higher throughput at sustainable rates, reducing safety related events and minimizing potential environmental impacts. Multivariate process deviations occur when the relationships amongst many process characteristics are different from the expected. The fault detection ability of methods such as principal component analysis (PCA) and process monitoring has been reported in literature and demonstrated in selective practical applications. However, the methodologies employed to diagnose the reason for the identified multivariate process faults have not gained the anticipated traction in practice. One explanation for this might be that the current diagnostic approaches attempt to rank process variables according to their individual contribution to process faults. However, the lack of these approaches to correctly identify the variables responsible for the process deviation is well researched and communicated in literature. Specifically, these approaches suffer from a phenomenon known as fault smearing. In this research it is argued, using several illustrations, that the objective of assigning individual importance rankings to process variables is not appropriate in a multivariate setting. A new methodology is introduced for performing fault diagnosis in multivariate process monitoring. More specifically, a multivariate diagnostic method is proposed that ranks variable pairs as opposed to individual variables. For PCA based MSPM, a novel fault diagnosis method is developed that decomposes the fault identification statistics into a sum of parts, with each part representing the contribution of a specific variable pair. An approach is also developed to quantify the statistical significance of each pairwise contribution. In addition, it is illustrated how the pairwise contributions can be analysed further to obtain an individual importance ranking of the process variables. Two methodologies are developed that can be applied to calculate the individual ranking following the pairwise contributions analysis. However, it is advised that the individual rankings should be interpreted together with the pairwise contributions. The application of this new approach to PCA based MSPM and fault diagnosis is illustrated using a simulated data set.
- Published
- 2021
85. An operational framework to improve municipal infrastructure grant spending in North-West Province, South Africa
- Author
-
Kopung, Seboka, Lubbe, Sam, 22543635 - Lubbe, Samuel Izak (Supervisor), Lubbe, S.I., Klopper, R,M., Meyer, J., 22903836 - Klopper, Rembrandt Marius (Supervisor), Lubbe, S., Klopper, R., Meyer, Jan A., and 22714928 - Meyer, Jan Abraham (Supervisor)
- Abstract
PhD (Business Management and Administration), North-West University, Mafikeng Campus, 2017 The study has identified the adverse impact of under-expenditure of Municipal Infrastructure Grant (MIG) projects in North West Province. This study focuses on the extent to which the application of MIG processes is affected by the enabling environment in North West Province. The research objectives are: to determine the primary reasons for under-expenditure in MIG projects; identify the roles of all stakeholders in MIG projects, including in the Project Management Unit (PMU); determine the issues faced within the procurement division that impact municipal spending; quantify the extent to which under-expenditure directly contributes to inefficient service delivery; consolidate the findings of under-spending of MIG funds; and apply research findings to determine the new framework for spending. Questionnaires were used to collect quantitative data from different local municipalities within North West Province. Secondary data was sourced from the Department of Human Settlement and Traditions (DHST) and annual reports and audited annual reports from the Provincial Auditor-General. A framework was developed using different statistical analysis and findings from other research approaches. It was refined through focus group inputs. Qualitative content analysis was used to develop the final framework. The focus group interviews revealed that MIG underspending was due to the following: (i) lack of independence by PMUs; (ii) the need to meet strict time frames; (iii) poorly functioning intergovernmental relations (IGR); (iv) procurement plans not being adhered to; (v) competent service providers not always being appointed; (vi) lack of involvement of communities through the project life cycle; (vii) lack of clear-cut policies regarding MIGs; and (viii) limitations on change management, requiring reduction in high staff turnover and the appointment of PMUs on a permanent basis. A refined framework resulted from the interview. Recommendations are made based on this refined framework. In conclusion, it was found that total spending of MIG funds does not necessarily mean the backlog has been eradicated. The implementation of a proper framework will assist in proper expenditure of MIG funds. Secondly, it will eradicate service backlogs and minimise service delivery protests. It will result in provision of essential services to the communities that so direly need these. Finally, minimal amounts will be returned unspent to the National Treasury. Doctoral
- Published
- 2017
86. Assessment of antenatal maternity service quality among patients at Mafikeng Provincial Hospital
- Author
-
Mushunje, Munyaradzi and Lubbe, S.
- Abstract
MBA North-West University, Mafikeng Campus, 2016 The purpose of this study was to assess antenatal maternity service quality among patients at Mafikeng Provincial Hospital in the North – West Province. Quantitative research using a SERVQUAL based questionnaire was carried out to determine the expectations and perceptions of antenatal patients on MPH antenatal service quality. Correlation studies were used to determine the relationship of expectations and perceptions on service quality. A total of 80 questionnaires were randomly handed out to antenatal patients over a two-week period of which 70 were successfully completed. The results of the study showed that antenatal patients have high expectations of MPH antenatal service quality and patients generally had positive perceptions on the quality of service they receive. Mixed responses were however obtained in areas involving clinic operating times and the ability of maternity staff to perform work right the first time. Findings of this research study were used to draw conclusions on antenatal care service quality. The study concluded with recommendations as well as highlighting possible areas of further research. Masters
- Published
- 2016
87. ICT based management initiatives : a case of Ratlou Municipality
- Author
-
Mokitime, Vuyo, Lubbe, S., and 22543635 - Lubbe, Samuel Izak (Supervisor)
- Abstract
MBA, North-West University, Mafikeng Campus In the rural areas, the poor typically lack access to information vital to their livelihoods. As a consequence, urban people are benefiting from the economy based on Information Technology Communication (ICT). This research is aimed at investigating ICT practices in the rural areas of South Africa with emphasis to rural Ratlou Municipal area in North West. People in the rural areas usually lack access to information vital to their livelihoods. Technology is an "enabler" of useful data that is important towards changing the lives of collective groups of people. Empowering communities is vital not only to the community but helps in building the capability people's drive. Mutula and Mostert (2008) documented that "installing of technology in underdeveloped societies is merely a small part of what is needed to use information and communications technology for socio-economic development". "The existence of digital divides and digital exclusion has been described and debated" as said by Servon (2002). The conceptualisation of ICT in growth is also an argued issue, making it harder to correctly apply ICT to benefit the poor (Gxulwana, 2010). South Africa has progressed in moving into the electronic age despite boundaries in its policy and regulatory environment. "Mobile telecommunications networks have spread across the country; sophisticated ICT applications have been adopted by businesses and government; and the Internet provides a foundation for information flows and transactions in banking and financial services, universities and other scientific performing agencies, as well as in shopping and entertainment services" (Goldstuck & Abrahams, 2010). Masters
- Published
- 2016
88. The employability of FET Agricultural Graduates in the North West Province
- Author
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Salman, Mongezi Victor, Lubbe, S., and 22543635 - Lubbe, Samuel Izak (Supervisor)
- Abstract
MBA North-West University, Mafikeng Campus, 2015 There is consensus among analysts that South Africa’s unemployment is structural in the sense that the unemployed generally possess lower skills than what is required in the marketplace. In the context of increasing demand for skilled workers due to technical progress and the need to become more competitive globally, graduate unemployment would be expected to fall (Altizer, 2004). The study will investigate the employability of FET agricultural graduates in North West Province, finding that labour force and employment growth has been concentrated in further educational categories also closing gaps within the training institution. However, against expectations unemployment has risen amongst young and better educated people. The study suggests that the education sector urgently requires continued emphasis and monitoring to ensure that learners are adequately prepared for entry into the labour force that better efforts, to encourage learners to choose directions of study with superior employment prospects; and that investment in young people’s soft skills is required. Masters
- Published
- 2015
89. An evaluation of perfomance management in the Department of Public Works, Roads and Transport of the North West Privince
- Author
-
Maine, S E and Lubbe, S.
- Subjects
Employees ,Perfomance ,Rating of - Abstract
Thesis (MBA) North-West University, Mafikeng Campus, 2014 Effective performance management is vital in all public and private sectors and contributes to service delivery of the organisations. Research on public-sector performance management, however, points out challenges in the implementation of the systems and questions the effectiveness of policy tools for enhancing the governmental accountability. The Department of Public Works, Roads and Transport is a large institution and its vision is to provide successful infrastructure projects and safer transport for the community. The majority of employees are working on infrastructure projects for both roads and buildings. In this study, experimental data and performance management experiences of the working environment to estimate the influence of Management of the Department of Public Works, Roads and Transport on the implementation of performance management policies, was analysed. The challenge is that the department focuses more on the work to be done than ensuring that the employees are also satisfied. The Department of Public Service and Administration (DPSA) and North West Provincial Treasury have implemented the performance management policies that need to be followed and practiced to improve service delivery as well as employee motivation. Management of the Department of Public Works, Roads and Transport, together with the Corporate Support Division should put into operation a strategy for the future in order to successfully implement the performance management system to all levels of employees in order to successfully achieve both employee satisfaction and retention, and the goa ls of the department. The Performance Management policies and legislations that is currently operational should be applied effectively and efficiently to improve service delivery and the morale of employees. Masters
- Published
- 2014
90. An empirical investigation into Green solutions in NWU (Mafikeng Campus)
- Author
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Klink, Shirene, Lubbe, S., and 22543635 - Lubbe, Samuel Izak (Supervisor)
- Subjects
Knowledge ,Stakeholders ,Sustainability ,Research ,ComputingMilieux_COMPUTERSANDEDUCATION ,Higher education ,Green Campus ,Carbon footprint ,Resources ,Environmental ,Educate - Abstract
Thesis (MBA) North-West University, Mafikeng Campus, 2014 A green campus can be defined as a higher education community that is improving energy efficiency, conserving resources and enhancing environmental quality by educating for sustainability and creating healthy living and learning environment. The research contained herein, aims to study the green activities currently on NWU Mafikeng Campus. The implication of this study serves to ensure that there are clear objectives with regard to adopting and promoting green education and awareness and to try for the implementation and promotion of new innovative green teaching methods. The result shows that is there is no consensus that the campus has clear objectives to promote a green campus and also no conclusive comment on the questions of if the campus continues to promote new methods of energy, water and waste consumption on the campus. One of the main objectives of a green building is to promote the construction of energy and resource efficient buildings but respondents could not comment on whether campus implements environmental impact assessments for new and existing buildings. However, students indicated they would be interested in attending green campus modules to effectively gain education on green and environmental affairs. Masters
- Published
- 2014
91. An evaluation of enterprise risk management in the financial office, North West University, Mafikeng Campus
- Author
-
Monakwane, Thebe, Lubbe, S., and 22543635 - Lubbe, Samuel Izak (Supervisor)
- Abstract
MBA, North-West University, Mafikeng Campus Any business operation/transaction is known as risk for reward. It is the objective of any business to reduse risks that hinder business operation in order to increase return. This is the case in any business irrespective of size, industry and location. Risks are inherent in every business.In recent years, implementation of Enterprise Risk Management (ERM) is being perceived as a necessity; in order to manage enterprise wide risks, to create risk awareness amongst employees and be more proactive in managing risks. The need for this study came as a result of a need to measure and optimises ERM as a business enabler. This study evaluates the effectiveness and appropriateness of ERM within the financial office, North West University Mafikeng Campus. This study also evaluated ERM frameworks that can be used in risk identification and management. These frameworks can be used to ease implementation, monitoring and evaluating ERM process, without a framework management it will be difficult or more complicated to manage risks effectively. Masters
- Published
- 2014
92. Investigation into organisational performance using strategic planning and resources: a study of listed companies in Zimbabwe
- Author
-
Ngwenya, Bongani, Lubbe, S., Klopper, R., and 22543635 - Lubbe, Samuel Izak (Supervisor)
- Subjects
Adaptability ,Financial ratios ,Organisational performance ,Retention ,Strategic planning ,Sales revenues ,Competitive advantage ,Resources configuration ,Core competencies - Abstract
PhD (Business & Public Management), North-West University, Mafikeng Campus, 2014 This study sought to investigate the link or relationship between strategic planning, resources configuration and organisational performance in a developing country context (Zimbabwe). Most of the research done in this area is based on the developed countries context. The study undertook to contribute fmiher to the debate on strategic management, the conception that strong organisational performance is a predictor of strategic planning capability of the top managers of corporations and how they have capably configured the companies' resources. The researcher gathered data from 58 companies listed on the Zimbabwe Stock Exchange, located in Harare and Bulawayo, by means of a questionnaire and an interview protocol. The major finding of this research was the feedback loop established between organisational performance, strategic planning and resources configuration capability by top managers. The top managers of the Zimbabwe Stock Exchange listed companies view the financial performance of their companies as a predictor of their strategic planning and company resources configuration capability. It was found that variation in the mean organisational performance accounted for 37.5% of the variation in the mean strategic planning capability. It was also found that variation in the mean organisational performance accounted for 36.0% of the variation in the mean strategic resources configuration capability. Furthermore, variation in the mean formal strategic planning accounted for 37.5% of the variation in the mean financial ratio growth. Variation in the mean strategic resources configuration accounted for 37.6% of the variation in the mean financial ratio growth. Furthermore, variation in the mean formal strategic planning accounted for 31.4% of the variation in the mean company adaptability to the external environment, while variation in the mean strategic resources configuration accounted for 37.6% of the variation in the mean company adaptability to external environment. Furthermore, variation in the mean formal strategic planning accounted for 19.7% of the variation in the mean retention ability, while variation in the mean strategic resources configuration accounted for 37.6% of the variation in the mean retention ability. Strategic resources configurations accounted for the higher variation in the means of all the variables of the phenomenon under study with an average of 37.0%, affirming the researcher's proposition that strategic resources are critical components of strategic management that cannot be relegated to the peripheries of management practices as they are portrayed in past studies and literature on strategic management. The study propounded, among its findings, a research theory which was extrapolated from the data collected using the two data-collecting instruments mentioned earlier on. Doctoral
- Published
- 2014
93. An empirical investigation into factors affecting the use of banking technologies by elderly citizens
- Author
-
Mosolotsane, Lebogang and Lubbe, S.
- Abstract
MBA North-West University, Mafikeng Campus, 2013 In this highly competitive business environment, banks are faced with the challenges of providing products which are relevant to their customers. In a quest of achieving this, there is a possibility of banks to redesign and integrate business processes and channels to achieve better market share. Karjaluoto et al. (2002) maintain that banks should keep a close look on how their customers respond towards service and products that are offered to them. This study determined the factors affecting the use of banking technologies by elderly citizens as customers of the banks. A quantitative research methodology was utilised in this study. A survey was conducted and 66 elderly citizens responded to the questionnaire administered to them. The study reveals that elderly citizens have average access to banking technologies and mostly A TM and the actual bank branch. Furthermore, the study reveals that elderly citizens are not comf01iable with using technological banking service and products due to lack of trust and confidence and futhermore they prefer human interaction when it comes to banking activities. Masters
- Published
- 2013
94. The integration of Information and Communication Technology in the Curriculum of North West Province schools: Mafikeng High Schools
- Author
-
Mmolawa, Evelyn Mashudu, Lubbe, S., and 22543635 - Lubber, Samuel Izak (Supervisor)
- Subjects
ComputingMilieux_COMPUTERSANDEDUCATION - Abstract
MBA North-West University, Mafikeng Campus, 2013 The integration of Information and Communication Technology (ICT) in and for education is rapidly expanding in many countries and is now seen worldwide as both a necessity and an opportunity for improving and enhancing education offered to citizens across the globe (UNESCO, 2006). The education system does not only pursue the integration of ICT into the curriculum because of its popularity in the market system, but because of the role it is perceived to play in the changing curriculum. According to the White Paper 7 on eEducation policy (2004: 17) every South African learner should be able to use ICT tools confidently and creatively to develop the skills and knowledge they need to achieve personal goals and to be full participants in the global community by 2013. The central role played by teachers in teaching and learning requires them to have a holistic understanding of ICT integration. Furthermore they should be able to analyse when integration is appropriate according to what is expected from the learner in the teaching and learning process. The study sought to address this research question: what are teachers' perceptions regarding integrating ICT with the curriculum in the classroom? Drawing on the evidence from a survey of eighteen/twenty one high schools in the Mafikeng Area Office of North West, the findings show that teachers use ICT tools to differing degrees, depending on their perspectives relative to ICT and their levels of professional experience. The significant ideas of how teachers perceive the integration of ICT tools into the curriculum emerge from what they view as benefits of using ICT and what they view as challenges when integrating ICT into the curriculum. In order to integrate ICT meaningfully into the teaching and learning activities teachers need both commitment and the technological skills. Contrary to expectation, the degree of ICT integration within the curriculum did not correspond directly with the availability of sufficient hardware, software or internet connectivity at the participating schools. Masters
- Published
- 2013
95. An empirical investigation on quality of information used for decision making in the Department of Social Development, Bojanala District
- Author
-
Molema, Nkgomoditse Georgina and Lubbe, S.
- Abstract
Thesis (MBA) North-West University, Mafikeng Campus, 2013 An organisation depends on quality information for effective operations and decision making, thus quality in management decision plays a vital role; and there is a direct and strong relationship between the quality of information used by a decision maker and decision performance. Hence lnforrnation is not an isolated resource, but it flows within organisation and, consequently, its quality must be tackled as an organisational issue (Caballero et al., 2008). Given these arguments, information quality should be a process intertwined to all business core processes because it is a means to an end; and indirectly impacts the bottom line of an organisation. This is not a fact at Department of Social Development, Bojanala District were Information Quality is not prioritised and integrated within all programs it delivers, hence this study is to investigate the impact that information quality has on managerial decisions within a financial Services Firm. In this study, the primary data will be collected by means of survey using a structured questionnaire. A survey will be conducted to test the association between information quality and managerial decisions, with an aim to establish the extent to which the information quality impact on managerial decisions. In the public sector, competition is not aimed at winning the market, but ensuring that service provisions are improved because, the public sector bodies must answer to the Ministers and Government secretaries and the citizens. Legislative mechanism and budgetary constraints also determine the scope of decision making. Therefore organisation must compare its performance against those of similar organisation and its past records. Moreover they may have reasons to work together or collaborate in different areas, in order to achieve their common objective (McBride ct al., 20 13). The findings of this research reveals that managers are aware of Information Quality and they do make decisions but the efficiency and consistency is not understood by many hence like any other organisation the department is faced with changes in the environment which brings along a new wave of challenges. The Department has to continually adapt its strategies and programmes to fit these managerial decision making changes. An assessment of the environment then becomes a continuous process. In order for the department to thrive it will need competent and skilled human resources. The Department of Social Development Bojanala District should therefore invest in fruitful Information development programmes if it plans to win or manage these challenges. Masters
- Published
- 2013
96. Implementation of LED initiatives in the Siyanda District MunicipalityNorthern Cape
- Author
-
Motabogi, Molebogeng Hildah, Lubbe, S., and 22543635 - Lubbe, Samuel Izak (Supervisor)
- Abstract
MBA, North-West University, Mahikeng Campus Inadequate human and financial capital led to LED units to be stagnant. Taking all these issues into account, the purpose of the study was to investigate the nonperformance of LED initiatives and departments in the district. A qualitative approach was use to collect data. The data was discussed and recommended actions were made. These include the use the current initiatives to assist municipalities and to reestablish the LED fund . Masters
- Published
- 2012
97. Attration and retention of qualified academics at the North-West University, Mafikeng Campus
- Author
-
Makondo, Livingstone and Lubbe, S.
- Subjects
Employees ,Recruiting ,Employee retention - Abstract
Thesis (MBA) North-West University, Mafikeng Campus, 2012 Purpose This study examined the extent to which the North-West University, Mafikeng Campus (NWU, MC) is managing to attract and retain properly qualified academics. Methodology This predominantly quantitative study has questionnaires responded to by hundred and sixty respondents and survey money responded to by fifty-two respondents were used to gather data from deans, directors and teaching staff at the NWU, MC and from other universities. Findings Attraction and retention of properly qualified and experienced academics emerges as a University's key strategic mandate as such personnel champions an institution's quest to deliver quality teaching-learning, research and community engagement. The study also notes that the NWU, MC is not doing well in terms of attracting and retaining properly qualified academics, a regrettable trend. The need for a proper mix of workload, work and personal life balance, remuneration and promotion among others emerged as key attraction and retention tenets. Conclusion The study concludes that attraction and retention of academics is a global challenge. The NWU, MC and other affected universities need to do all they can to curtail the challenge so that they can attract and retain properly qualified and experienced academics for them to boost their throughput and graduation rates. These achievements, among others would ensure that the university' customers would be satified at the same time the university would attract funding. Recommendation It emerges that a university that offers longer contracts stands better chances to attract and retain academics. To this end, this study shares several pertinent insights that can help the NWU, MC ameliorate the challenge. Masters
- Published
- 2012
98. Job satisfaction and organisational commitment amongst primary school educators in rural areas : the case of Kagisano Molopo Area Office
- Author
-
Biekies, Kedihentse Ella, Lubbe, S., and 22543635 - Lubbe, Samuel Izak (Supervisor)
- Abstract
MBA, North-West University, Mafikeng Campus, 2012 This study investigates the relationship between job satisfaction and organisational commitment. The study also serves as an evaluative and descriptive tool towards the relationship between job satisfaction and organisational commitment amongst educators in rural areas of the Kagisano Molopo Area Office. The study is aimed to assist the district and provincial management to understand issues that contribute to job dissatisfaction amongst educators in rural schools. It further suggests the application of the components of organisational commitment for developing a healthy culture in schools to achieve educational goals. Key words: Job satisfaction, organisational commitment and primary school educators. Masters
- Published
- 2012
99. Evaluation and analysis of substantive and procedural management of dismissals in the department of Justice (specifically master of the North Gauteng High Court, Pretoria)
- Author
-
Makhubedu, Yvonne and Lubbe, S.
- Subjects
Employees ,dismisal of - Abstract
Thesis (MBA) North-West University, Mafikeng campus, 2012 After a review of the literature relevant to dismissal management systems been over time and across different government departments, this thesis confines it's relevant to case study of the department and implementation of a dismissal management system in the department of Justice (Master of the High Court). Collection followed for the relevant data by a discussion of the development and implementation of the dismissal management system at the Master of the High Court over period of five years from 1st June 2007 to 31st May 2011 . Next, an analysis of major themes that emerged from the research, in terms of important items for consideration in the development and implementation of a dismissal management system in the department of Justice. After analysing the relevant information, it became apparent that the dismissal management system has no direct influence on the delay of the Master of the High Court. Although the department of Justice is dismissal management systems undergoes continual improvement, significant inroads have been made into providing a sensible, clear and dynamic solution to the problem of rewarding efficient and effective dismissal management system in a number of ways. Masters
- Published
- 2012
100. Reconceptualising an e–Learning framework for South African public sector training
- Author
-
Mkhize, Peter L'Hlonono, Huisman, H.M., Lubbe, S., and 10066896 - Huisman, Hester Magrietha (Supervisor)
- Subjects
Socially orientated instructional technology ,Skills development ,E-Learning ,Diffusion of innovation ,Socially orientated instructional strategy - Abstract
Thesis(PhD (Computer Science))--North-West University, Potchefstroom Campus, 2013. The emerging knowledge economy necessitates rapid skills development, to ensure that organisations sustain a competitive edge. Rapid skills acquisition would enable organisations, whether public or private sector, to take advantage of new emerging opportunities and improve performance by ensuring that their employees are well equipped with relevant skills. The South African labour market has, however, been engulfed by both a skills shortage and a brain drain, which has worsened performance in the public sector – as is evident from the widespread public protests. In this study, the researcher conducted an explorative investigation to gain an in-depth understanding of factors that could influence e-Learning diffusion as an innovative way of facilitating rapid skills acquisition. In order to conduct this investigation, the researcher employed qualitative techniques in the form of a case study, using grounded theory analysis techniques. Grounded theory analysis results enabled the researcher to formulate propositions. Furthermore, these propositions were used to formulate important factors and questionnaire items that were used to test proposed findings, using a survey research design. Findings revealed that the public sector, as with society at large, is adopting socially orientated computing practices, to open up social platform integration into the employee learning experience. Findings reveal that social platform integration would be fruitful, if the entire instructional design was based on social constructivist, epistemological principles, with the appropriate social technology. Doctoral
- Published
- 2012
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