Author: "Labalme A." - Searchworks@Jio Institute Digital Library Search Results

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1,265 results on '"Labalme A."'

51. A novel truncating variant p.(Arg297*) in the GRM1 gene causing autosomal-recessive cerebellar ataxia with juvenile-onset

Author: Cabet, Sara, Putoux, Audrey, Carneiro, Maryline, Labalme, Audrey, Sanlaville, Damien, Guibaud, Laurent, and Lesca, Gaetan
Published: 2019
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52. Chromatin remodeling dysfunction extends the etiological spectrum of schizophrenia: a case report

Author: Alice Poisson, Nicolas Chatron, Audrey Labalme, Pierre Fourneret, Dorothée Ville, Marie Laure Mathieu, Damien Sanlaville, Caroline Demily, and Gaëtan Lesca
Subjects: Schizophrenia, Childhood onset schizophrenia, CHD2, Genetic counselling, Chromatin, Chromodomain helicase DNA-binding, Internal medicine, RC31-1245, Genetics, QH426-470
Abstract: Abstract Background The role of deleterious copy number variations in schizophrenia is well established while data regarding pathogenic variations remain scarce. We report for the first time a case of schizophrenia in a child with a pathogenic mutation of the chromodomain helicase DNA binding protein 2 (CHD2) gene. Case presentation The proband was the second child of unrelated parents. Anxiety and sleep disorders appeared at the age of 10 months. He presented febrile seizures and, at the age of 8, two generalized tonic-clonic seizures. At the age of 10, emotional withdrawal emerged, along with a flat affect, disorganization and paranoid ideation, without seizures. He began to talk and giggle with self. Eventually, the patient presented daily auditory and visual hallucinations. The diagnosis of childhood onset schizophrenia (DSM V) was then evoked. Brain imaging was unremarkable. Wakefulness electroencephalography showed a normal background and some bilateral spike-wave discharges that did not explain the psychosis features. A comparative genomic hybridization array (180 K, Agilent, Santa Clara, CA, USA) revealed an 867-kb 16p13.3 duplication, interpreted as a variant of unknown significance confirmed by a quantitative PCR that also showed its maternal inheritance. Risperidone (1,5 mg per day), led to clinical improvement. At the age of 11, an explosive relapse of epilepsy occurred with daily seizures of various types. The sequencing of a panel for monogenic epileptic disorders and Sanger sequencing revealed a de novo pathogenic heterozygous transition in CHD2 (NM_001271.3: c.4003G > T). Conclusions This case underlines that schizophrenia may be, sometimes, underpinned by a Mendelian disease. It addresses the question of systematic genetic investigations in the presence of warning signs such as a childhood onset of the schizophrenia or a resistant epilepsy. It points that, in the absence of pathogenic copy number variation, the investigations should also include a search for pathogenic variations, which means that some of the patients with schizophrenia should benefit from Next Generation Sequencing tools. Last but not least, CHD2 encodes a member of the chromodomain helicase DNA-binding (CHD) family involved in chromatin remodeling. This observation adds schizophrenia to the phenotypic spectrum of chromodomain remodeling disorders, which may lead to innovative therapeutic approaches.
Published: 2020
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53. Molecular and Phenotypic Characterization of the RORB-Related Disorder

Author: Gokce-Samar, Zeynep, primary, Vetro, Annalisa, additional, De Bellescize, Julitta, additional, Pisano, Tiziana, additional, Monteiro, Laloe, additional, Penaud, Noémie, additional, Korff, Christian M., additional, Fluss, Joel, additional, Marini, Carla, additional, Cesaroni, Elisabetta, additional, Alvarez, Blanca Mercedes, additional, Sanlaville, Damien, additional, Chatron, Nicolas, additional, Arzimanoglou, Alexis A., additional, Labalme, Audrey, additional, Cuddapah, Vishnu A., additional, Ruggiero, Sarah M., additional, Lecoquierre, Francois, additional, Nicolas, Gael, additional, Marie, Guerrot Anne, additional, Lebas, Axel, additional, Testard, Herve O., additional, Helbig, Katherine L., additional, Ruiz, Anna, additional, Ngoh, Adeline, additional, Kurian, Manju A., additional, Reid, Kimberley, additional, Spaull, Robert, additional, Joset, Pascal, additional, Ramantani, Georgia, additional, Steindl, Katharina, additional, Krenn, Martin, additional, Gerstl, Lucia, additional, Vieker, Silvia, additional, Craiu, Dana, additional, Pendziwiat, Manuela, additional, Haldeman-Englert, Chad, additional, Kanivets, Ilya, additional, Romanova, Irina, additional, Rajan, Deepa S., additional, Rosenfeld, Jill A., additional, Au, Margaret, additional, Grand, Katheryn, additional, Graham, John M., additional, Isapof, Arnaud, additional, Villeneuve, Nathalie, additional, Smol, Thomas, additional, Caumes, Roseline, additional, Zacher, Pia, additional, Neuser, Sonja, additional, Tinschert, Sigrid, additional, Platzer, Konrad, additional, Bartolomaeus, Tobias, additional, Mohnke, Ines, additional, Radtke, Maximilian, additional, Jamra, Rami Abou, additional, Helbig, Ingo, additional, Jansen, Floortje E., additional, Koop, Klaas, additional, Rudolf, Gabrielle, additional, Küry, Sebastien, additional, Courchet, Julien, additional, Guerrini, Renzo, additional, and Lesca, Gaetan, additional
Published: 2023
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54. GRM7-related disorder: Five additional patients from three independent families and review of the literature

Author: Januel, Louis, primary, Chatron, Nicolas, additional, Rivier Ringenbach, Clotilde, additional, Cabet, Sara, additional, Labalme, Audrey, additional, Sahin, Yavuz, additional, Darvish, Hossein, additional, Kruer, Michael, additional, Bakhtiari, Somayeh, additional, Sanlaville, Damien, additional, de Sainte Agathe, Jean Madeleine, additional, and Lesca, Gaetan, additional
Published: 2023
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55. Paul trapping of radioactive 6He+ions and direct observation of their beta-decay

Author: Flechard, X., Lienard, E., Mery, A., Rodriguez, D., Ban, G., Durand, D., Duval, F., Herbane, M., Labalme, M., Mauger, F., Naviliat-Cuncic, O., Thomas, J. C., and Velten, Ph.
Subjects: Nuclear Experiment
Abstract: We demonstrate that abundant quantities of short-lived beta unstable ions can be trapped in a novel transparent Paul trap and that their decay products can directly be detected in coincidence. Low energy 6He+ (807 ms half-life) ions were extracted from the SPIRAL source at GANIL, then decelerated, cooled and bunched by means of the buffer gas cooling technique. More than 10^8 ions have been stored over a measuring period of six days and about 10^5 decay coincidences between the beta particles and the 6Li^{++} recoiling ions have been recorded. The technique can be extended to other short-lived species, opening new possibilities for trap assisted decay experiments., Comment: 4 pages, 4 figures, submitted to Phys.Rev.Lett
Published: 2008
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56. Molecular investigation, using chromosomal microarray and whole exome sequencing, of six patients affected by Williams Beuren syndrome and Autism Spectrum Disorder

Author: Julie Masson, Caroline Demily, Nicolas Chatron, Audrey Labalme, Pierre-Antoine Rollat-Farnier, Caroline Schluth-Bolard, Brigitte Gilbert-Dussardier, Fabienne Giuliano, Renaud Touraine, Sylvie Tordjman, Alain Verloes, Giuseppe Testa, Damien Sanlaville, Patrick Edery, Gaetan Lesca, and Massimiliano Rossi
Subjects: Autism Spectrum Disorder, Williams Beuren syndrome, 7q11.23 microdeletion, GTF2I, Whole exome sequencing, Medicine
Abstract: Abstract Williams Beuren syndrome (WBS) is a multiple malformations/intellectual disability (ID) syndrome caused by 7q11.23 microdeletion and clinically characterized by a typical neurocognitive profile including excessive talkativeness and social disinhibition, often defined as “overfriendliness” and “hyersociability”. WBS is generally considered as the polar opposite phenotype to Autism Spectrum Disorder (ASD). Surprisingly, the prevalence of ASD has been reported to be significantly higher in WBS (12%) than in general population (1%). Our study aims to investigate the molecular basis of the peculiar association of ASD and WBS. We performed chromosomal microarray analysis and whole exome sequencing in six patients presenting with WBS and ASD, in order to evaluate the possible presence of chromosomal or gene variants considered as pathogenic. Our study shows that the presence of ASD in the recruited WBS patients is due to i) neither atypically large deletions; ii) nor the presence of pathogenic variants in genes localized in the non-deleted 7q11.23 allele which would unmask recessive conditions; iii) moreover, we did not identify a second, indisputable independent genetic diagnosis, related to pathogenic Copy Number Variations or rare pathogenic exonic variants in known ID/ASD causing genes, although several variants of unknown significance were found. Finally, imprinting effect does not appear to be the only cause of autism in WBS patients, since the deletions occurred in alleles of both maternal and paternal origin. The social disinhibition observed in WBS does not follow common social norms and symptoms overlapping with ASD, such as restricted interests and repetitive behavior, can be observed in “typical” WBS patients: therefore, the terms “overfriendliness” and “hypersociability” appear to be a misleading oversimplification. The etiology of ASD in WBS is likely to be heterogeneous. Further studies on large series of patients are needed to clarify the observed variability in WBS social communication, ranging from excessive talkativeness and social disinhibition to absence of verbal language and social deficit.
Published: 2019
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57. Electrical status epilepticus in sleep, a constitutive feature of Christianson syndrome?

Author: Mathieu, Marie-Laure, de Bellescize, Julitta, Till, Marianne, Flurin, Vincent, Labalme, Audrey, Chatron, Nicolas, Sanlaville, Damien, Chemaly, Nicole, des Portes, Vincent, Ostrowsky, Karine, Arzimanoglou, Alexis, and Lesca, Gaëtan
Published: 2018
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58. P079 / #720 - DEVELOPMENT OF A 3-DIMENSION SCINTILLATION DOSIMETER FOR SMALL IRRADIATION FIELDS CONTROL IN PENCIL BEAM SCANNING PROTON THERAPY

Author: Fontbonne, Jean-Marc, Lebhertz, Dorothee, Moignier, Cyril, Thariat, Juliette, Vela, Anthony, Fontbonne, Cathy, and Labalme, Anne-Marie Frelin
Published: 2024
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59. A Spirobifluorene-Based Covalent Organic Framework for Dual Photoredox and Nickel Catalysis

Author: Fan, Yingjie, primary, Kang, Dong Won, additional, Labalme, Steven, additional, and Lin, Wenbin, additional
Published: 2023
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60. GRIN1 variants associated with neurodevelopmental disorders reveal channel gating pathomechanisms

Author: Ragnarsson, Lotten, primary, Zhang, Zihan, additional, Das, Sooraj S., additional, Tran, Poanna, additional, Andersson, Åsa, additional, des Portes, Vincent, additional, Desmettre Altuzarra, Cecilia, additional, Remerand, Ganaelle, additional, Labalme, Audrey, additional, Chatron, Nicolas, additional, Sanlaville, Damien, additional, Lesca, Gaetan, additional, Anggono, Victor, additional, Vetter, Irina, additional, and Keramidas, Angelo, additional
Published: 2023
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61. CMOS active pixel sensors response to low energy light ions

Author: Spiriti, E., Finck, Ch., Baudot, J., Divay, C., Juliani, D., Labalme, M., Rousseau, M., Salvador, S., Vanstalle, M., Agodi, C., Cuttone, G., De Napoli, M., and Romano, F.
Published: 2017
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62. Prenatal microarray comparative genomic hybridization: Experience from the two first years of activity at the Lyon university-hospital

Author: Pons, L., Till, M., Alix, E., Abel, C., Boggio, D., Bordes, A., Caloone, J., Raskin, F.C., Chatron, N., Cordier, M.-P., Fichez, A., Labalme, A., Lajeunesse, C., Liaras, É., Massoud, M., Miribel, J., Ollagnon, E., Schluth-Bolard, C., Vichier-Cerf, A., Edery, P., Attia, J., Huissoud, C., Rudigoz, R.C., Massardier, J., Gaucherand, P., and Sanlaville, D.
Published: 2017
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63. Molecular Engineering of Metal–Organic Layers for Sustainable Tandem and Synergistic Photocatalysis

Author: Yingjie Fan, Haifeng Zheng, Steven Labalme, and Wenbin Lin
Subjects: Colloid and Surface Chemistry, General Chemistry, Biochemistry, Catalysis
Published: 2023
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64. Metal–Organic Layers with Photosensitizer and Pyridine Pairs Activate Alkyl Halides for Photocatalytic Heck-Type Coupling with Olefins.

Author: Fan, Yingjie, Blenko, Abigail L., Labalme, Steven, and Lin, Wenbin
Published: 2024
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65. Nanobeacon: A time calibration device for the KM3NeT neutrino telescope

Author: Aiello, S., Albert, A., Alshamsi, M., Garre, S. Alves, Aly, Z., Ambrosone, A., Ameli, F., Andre, M., Androulakis, G., Anghinolfi, M., Anguita, M., Ardid, M., Ardid, S., Aublin, J., Bagatelas, C., Baret, B., Pree, S. Basegmez Du, Bendahman, M., Benfenati, F., Berbee, E., Berg, A. M. Den, Bertine, V., Biagi, S., Boettcher, M., Cabo, M. Bou, Boumaaza, J., Bouta, M., Bouwhuis, M., Bozza, C., Branza, H., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Caiffi, B., Calvo, D., Campion, S., Capone, A., Carretero, V., Castaldi, P., Celli, S., Chabab, M., Chau, N., Chena, A., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Molla, M. Colomer, Coniglione, R., Coyle, P., Creusot, A., Cruza, A., Cuttone, G., Dalliera, R., Martino, B., Di Palma, I., Diaz, A. F., Tortosa, D. Diego, Distefano, C., Domi, A., Donzau, C., Dornic, D., Dorra, M., Drouhin, D., Eberla, T., Eddyamoui, A., Eeden, T., Eijk, D., Bojaddaini, I. El, Hedri, S. El, Enzenhofer, A., Espinosa, V., Fermani, P., Ferrara, G., Filipovic, M. D., Filippini, F., Fusco, L. A., Gala, T., Mendez, J. Garcia, Garufi, F., Gatelet, Y., Oliver, C. Gatius, Geisselbrecht, N., Gialanella, L., Giorgio, E., Gozzini, S. R., Gracia, R., Grafa, K., Grella, G., Guderian, D., Guidi, C., Guillon, B., Gutierrez, M., Haefner, J., Hallmann, S., Hamdaoui, H., Harena, H., Heijboer, A., Hekaloa, A., Henniga, L., Hernandez-Rey, J. J., Hofestadt, J., Huang, F., Ibnsalih, W. Idrissi, Illuminati, G., James, C. W., Janezashvili, D., Jong, M., Jong, P., Jung, B. J., Kalaczynski, P., Kalekin, O., Katz, U. F., Chowdhury, N. R. Khan, Kistauri, G., Knaap, F., Kooijman, P., Kouchner, A., Kulikovskiy, V., Labalme, M., Lahmann, R., Lamoureux, M., Larosa, G., Lastori, C., Lazo, A., Breton, R. Le, Stum, S. Le, Lehaut, G., Leonardi, O., Leone, F., Leonora, E., Lessing, N., Levi, G., Lincetto, M., Clark, M. Lindsey, Lipreau, T., Alvarez, C. Llorens, Longhitano, F., Lopez-Coto, D., Maderer, L., Majumdar, J., Manczak, J., Margiotta, A., Marinelli, A., Markou, C., Martina, L., Martinez-Mora, J. A., Martini, A., Marzaioli, F., Mastroianni, S., Melis, K. W., Miele, G., Migliozzi, P., Migneco, E., Mijakowski, P., Miranda, L. S., Mollo, C. M., Moser, M., Moussa, A., Muller, R., Musumeci, M., Nauta, L., Sergio Navas, Nicolau, C. A., Nkosi, B., Ofearraigh, B., Osullivan, M., Organokov, M., Orlando, A., Gonzalez, J. Palacios, Papalashvilia, G., Papaleo, R., Paun, A. M., Pavala, G. E., Pellegrino, C., Perrin-Terrin, M., Pestel, V., Piattelli, P., Pieterse, C., Pisanti, O., Poire, C., Popa, V., Pradier, T., Probsta, I., Pulvirenti, S., Quemenera, G., Randazzo, N., Razzaquea, S., Real, D., Recka, S., Riccobene, G., Romanov, A., Rovelli, A., Greus, F. Salesa, Samtlebe, D. F. E., Losa, A. Sanchez, Sanguineti, M., Santonocito, D., Sapienza, P., Schnabel, J., Schneidera, M. F., Schumann, J., Schutte, H. M., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Stellaccian, S. M., Taiutik, M., Tayalati, Y., Thiersen, H., Tingay, S., Tsagkli, S., Tsourapis, V., Tzamariudaki, E., Tzanetatos, D., Elewyck, V., Vasileiadis, G., Versari, F., Vivolo, D., Wasseige, G., Wilmsa, J., Wojaczynski, R., Wolf, E., Yousfi, T., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zuniga, J., Zywucka, N., KM3NeT (IHEF, IoP, FNWI), Astroparticle Physics (IHEF, IoP, FNWI), ATLAS (IHEF, IoP, FNWI), IoP (FNWI), Centre Tecnològic de Vilanova i la Geltrú, Universitat Politècnica de Catalunya. LAB - Laboratori d'Aplicacions Bioacústiques, Research unit Astroparticle Physics, Department of Social Sciences, Groupe de Recherche en Physique des Hautes Energies (GRPHE), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-IUT de Colmar, Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Laboratoire Univers et Particules de Montpellier (LUPM), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), KM3NeT, ANR-18-IDEX-0001,Université de Paris,Université de Paris(2018), ANR-15-CE31-0020,DAEMONS,Démonstration de la possibilité d'établir l'ordonnancement des masses de neutrinos dans la mer(2015), ANR-10-LABX-0023,UnivEarthS,Earth - Planets - Universe: observation, modeling, transfer(2010), S. Aiello, A. Albert, M. Alshamsi, S. Alves Garre, Z. Aly, A. Ambrosone, F. Ameli, M. Andre, G. Androulaki, M. Anghinolfi, M. Anguita, M. Ardid, S. Ardid, J. Aublin, C. Bagatela, B. Baret, S. Basegmez du Pree, M. Bendahman, F. Benfenati, E. Berbee, A.M. van den Berg, V. Bertin, S. Biagi, M. Boettcher, M. Bou Cabo, J. Boumaaza, M. Bouta, M. Bouwhui, C. Bozza, H. Br??nza??, R. Bruijn, J. Brunner, R. Bruno, E. Bui, R. Buompane, J. Busto, B. Caiffi, D. Calvo, S. Campion, A. Capone, V. Carretero, P. Castaldi, S. Celli, M. Chabab, N. Chau, A. Chen, S. Cherubini, V. Chiarella, T. Chiarusi, M. Circella, R. Cocimano, J.A.B. Coelho, A. Coleiro, M. Colomer Molla, R. Coniglione, P. Coyle, A. Creusot, A. Cruz, G. Cuttone, R. Dallier, B. De Martino, I. Di Palma, A.F. D??az, D. Diego-Tortosa, C. Distefano, A. Domi, C. Donzaud, D. Dornic, M. D??rr, D. Drouhin, T. Eberl, A. Eddyamoui, T. van Eeden, D. van Eijk, I. El Bojaddaini, S. El Hedri, A. Enzenh??fer, V. Espinosa, P. Fermani, G. Ferrara, M.D. Filipovi??, F. Filippini, L.A. Fusco, T. Gal, J. Garc??a M??ndez, F. Garufi, Y. Gatelet, C. Gatius Oliver, N. Gei??elbrecht, L. Gialanella, E. Giorgio, S.R. Gozzini, R. Gracia, K. Graf, G. Grella, D. Guderian, C. Guidi, B. Guillon, M. Guti??rrez, J. Haefner, S. Hallmann, H. Hamdaoui, H. van Haren, A. Heijboer, A. Hekalo, L. Hennig, J.J. Hern??ndez-Rey, J. Hofest??dt, F. Huang, W. Idrissi Ibnsalih, G. Illuminati, C.W. Jame, D. Janezashvili, M. de Jong, P. de Jong, B.J. Jung, P. Kalaczy??ski, O. Kalekin, U.F. Katz, N.R. Khan Chowdhury, G. Kistauri, F. van der Knaap, P. Kooijman, A. Kouchner, V. Kulikovskiy, M. Labalme, R. Lahmann, M. Lamoureux, G. Larosa, C. Lastoria, A. Lazo, R. Le Breton, S. Le Stum, G. Lehaut, O. Leonardi, F. Leone, E. Leonora, N. Lessing, G. Levi, M. Lincetto, M. Lindsey Clark, T. Lipreau, C. LLorens Alvarez, F. Longhitano, D. Lopez-Coto, L. Maderer, J. Majumdar, J. Ma??czak, A. Margiotta, A. Marinelli, C. Markou, L. Martin, J.A. Mart??nez-Mora, A. Martini, F. Marzaioli, S. Mastroianni, K.W. Meli, G. Miele, P. Migliozzi, E. Migneco, P. Mijakowski, L.S. Miranda, C.M. Mollo, M. Moser, A. Moussa, R. Muller, M. Musumeci, L. Nauta, S. Nava, C.A. Nicolau, B. Nkosi, B. ?? Fearraigh, M. O???Sullivan, M. Organokov, A. Orlando, J. Palacios Gonz??lez, G. Papalashvili, R. Papaleo, A.M. P??un, G.E. P??v??la??, C. Pellegrino, M. Perrin-Terrin, V. Pestel, P. Piattelli, C. Pieterse, O. Pisanti, C. Poir??, V. Popa, T. Pradier, I. Probst, S. Pulvirenti, G. Qu??m??ner, N. Randazzo, S. Razzaque, D. Real, S. Reck, G. Riccobene, A. Romanov, A. Rovelli, F. Salesa Greu, D.F.E. Samtleben, A. S??nchez Losa, M. Sanguineti, D. Santonocito, P. Sapienza, J. Schnabel, M.F. Schneider, J. Schumann, H.M. Schutte, J. Seneca, I. Sgura, R. Shanidze, A. Sharma, A. Sinopoulou, B. Spisso, M. Spurio, D. Stavropoulo, S.M. Stellacci, M. Taiuti, Y. Tayalati, H. Thiersen, S. Tingay, S. Tsagkli, V. Tsourapi, E. Tzamariudaki, D. Tzanetato, V. Van Elewyck, G. Vasileiadi, F. Versari, D. Vivolo, G. de Wasseige, J. Wilm, R. Wojaczy??ski, E. de Wolf, T. Yousfi, S. Zavatarelli, A. Zegarelli, D. Zito, J.D. Zornoza, J. Z????iga, N. Zywucka, Aiello, S., Albert, A., Alshamsi, M., Garre, S. A., Aly, Z., Ambrosone, A., Ameli, F., Andre, M., Androulakis, G., Anghinolfi, M., Anguita, M., Ardid, M., Ardid, S., Aublin, J., Bagatelas, C., Baret, B., du Pree, S. B., Bendahman, M., Benfenati, F., Berbee, E., van den Berg, A. M., Bertin, V., Biagi, S., Boettcher, M., Cabo, M. B., Boumaaza, J., Bouta, M., Bouwhuis, M., Bozza, C., Branzas, H., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Caiffi, B., Calvo, D., Campion, S., Capone, A., Carretero, V., Castaldi, P., Celli, S., Chabab, M., Chau, N., Chen, A., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Molla, M. C., Coniglione, R., Coyle, P., Creusot, A., Cruz, A., Cuttone, G., Dallier, R., De Martino, B., Di Palma, I., Diaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Dorr, M., Drouhin, D., Eberl, T., Eddyamoui, A., van Eeden, T., van Eijk, D., El Bojaddaini, I., El Hedri, S., Enzenhofer, A., Espinosa, V., Fermani, P., Ferrara, G., Filipovic, M. D., Filippini, F., Fusco, L. A., Gal, T., Mendez, J. G., Garufi, F., Gatelet, Y., Oliver, C. G., Geisselbrecht, N., Gialanella, L., Giorgio, E., Gozzini, S. R., Gracia, R., Graf, K., Grella, G., Guderian, D., Guidi, C., Guillon, B., Gutierrez, M., Haefner, J., Hallmann, S., Hamdaoui, H., van Haren, H., Heijboer, A., Hekalo, A., Hennig, L., Hernandez-Rey, J. J., Hofestadt, J., Huang, F., Ibnsalih, W. I., Illuminati, G., James, C. W., Janezashvili, D., de Jong, M., de Jong, P., Jung, B. J., Kalaczynski, P., Kalekin, O., Katz, U. F., Chowdhury, N. R. K., Kistauri, G., van der Knaap, F., Kooijman, P., Kouchner, A., Kulikovskiy, V., Labalme, M., Lahmann, R., Lamoureux, M., Larosa, G., Lastoria, C., Lazo, A., Le Breton, R., Le Stum, S., Lehaut, G., Leonardi, O., Leone, F., Leonora, E., Lessing, N., Levi, G., Lincetto, M., Clark, M. L., Lipreau, T., Alvarez, C. L., Longhitano, F., Lopez-Coto, D., Maderer, L., Majumdar, J., Manczak, J., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Martinez-Mora, J. A., Martini, A., Marzaioli, F., Mastroianni, S., Melis, K. W., Miele, G., Migliozzi, P., Migneco, E., Mijakowski, P., Miranda, L. S., Mollo, C. M., Moser, M., Moussa, A., Muller, R., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Nkosi, B., Fearraigh, B. O., O'Sullivan, M., Organokov, M., Orlando, A., Gonzalez, J. P., Papalashvili, G., Papaleo, R., Paun, A. M., Pavalas, G. E., Pellegrino, C., Perrin-Terrin, M., Pestel, V., Piattelli, P., Pieterse, C., Pisanti, O., Poire, C., Popa, V., Pradier, T., Probst, I., Pulvirenti, S., Quemener, G., Randazzo, N., Razzaque, S., Real, D., Reck, S., Riccobene, G., Romanov, A., Rovelli, A., Greus, F. S., Samtleben, D. F. E., Losa, A. S., Sanguineti, M., Santonocito, D., Sapienza, P., Schnabel, J., Schneider, M. F., Schumann, J., Schutte, H. M., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Stellacci, S. M., Taiuti, M., Tayalati, Y., Thiersen, H., Tingay, S., Tsagkli, S., Tsourapis, V., Tzamariudaki, E., Tzanetatos, D., Van Elewyck, V., Vasileiadis, G., Versari, F., Vivolo, D., de Wasseige, G., Wilms, J., Wojaczynski, R., de Wolf, E., Yousfi, T., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zuniga, J., and Zywucka, N.
Subjects: Astrofísica, Technology, Physics - Instrumentation and Detectors, Physics::Instrumentation and Detectors, costs, Neutrino telescope, Astrophysics, Physics, Particles & Fields, neutrino: atmosphere, optical, Instruments & Instrumentation, KM3NeT, Instrumentation, neutrino: interaction, glass, instrumentation, photomultiplier, Physics, Astrophysics::Instrumentation and Methods for Astrophysics, Instrumentation and Detectors (physics.ins-det), charged particle, Physics, Nuclear, neutrino: detector, Physical Sciences, Astrophysics - Instrumentation and Methods for Astrophysics, Time calibration, Nuclear and High Energy Physics, Astrophysics::High Energy Astrophysical Phenomena, neutrino telescopes, FOS: Physical sciences, Physique [physics]/Physique [physics], [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Neutrins, Nuclear Science & Technology, Instrumentation and Methods for Astrophysics (astro-ph.IM), Detectors òptics, Optical detectors, Science & Technology, Física [Àrees temàtiques de la UPC], Telescopis, time: calibration, neutrino: particle source, radiation: Cherenkov, BEACON, angular resolution, Terms—time calibration, FISICA APLICADA, High Energy Physics::Experiment, sphere, neutrino: oscillation, Neutrino telescopes, Astroparticle physics, Telescopes
Abstract: The KM3NeT Collaboration is currently constructing a multi-site high-energy neutrino telescope in the Mediterranean Sea consisting of matrices of pressure-resistant glass spheres, each holding a set of 31 small-area photomultipliers. The main goals of the telescope are the observation of neutrino sources in the Universe and the measurement of the neutrino oscillation parameters with atmospheric neutrinos. A relative time synchronisation between photomultipliers of the nanosecond order needed to guarantee the required angular resolution of the detector. Due to the large detector volumes to be instrumented by KM3NeT, a cost reduction of the different systems is a priority. To this end, the inexpensive Nanobeacon has been designed and developed by the KM3NeT Collaboration to be used for detector time-calibration studies. At present, more than 600 Nanobeacons have been already produced. The characterisation of the optical pulse and the wavelength emission profile of the devices is critical for the time calibration. The optical pulse rise time has been quantified as less than 3 ns, while the Full Width Half Maximum is less than 6 ns. The wavelength drift, due to a variation of the supply voltage, has also been qualified as lower than 10 nm for the full range of the Nanobeacon. In this paper, more details about the main features of the Nanobeacon design, production and operation, together with the main properties of the light pulse generated are described., French National Research Agency (ANR), European Commission ANR-15-CE31-0020, Centre National de la Recherche Scientifique (CNRS) Commission Europeenne (FEDER fund) Commission Europeenne (Marie Curie Program) Institut Universitaire de France (IUF) LabEx UnivEarthS, Paris Ile-de-France Region, France ANR-10-LABX-0023 ANR-18-IDEX-0001, Shota Rustaveli National Science Foundation of Georgia (SRNSFG), Georgia FR-18-1268, German Research Foundation (DFG), Greek Ministry of Development-GSRT, Istituto Nazionale di Fisica Nucleare (INFN), Ministero dell'Universita e della Ricerca (MIUR), PRIN 2017 program, Italy NAT-NET 2017W4HA7S, Ministry of Higher Education Scientific Research and Professional Training, ICTP, Morocco AF-13, Netherlands Organization for Scientific Research (NWO) Netherlands Government, National Science Centre, Poland 2015/18/E/ST2/00758, National Authority for Scientific Research (ANCS), Romania, Ministerio de Ciencia, Innovacion, Investigacion.. Universidades (MCIU): Programa Estatal de Generacion de Conocimiento PGC2018-096663-B-C41 PGC2018-096663-A-C42 PGC2018-096663-B-C43 PGC2018-096663-B-C44, Center for Forestry Research & Experimentation (CIEF) PROMETEO/2020/019, Generalitat Valenciana: Grisolia program GRISOLIA/2018/119 Generalitat Valenciana: GenT program CIDEGENT/2018/034 CIDEGENT/2019/043 CIDEGENT/2020/049, Junta de Andalucia A-FQM-053-UGR18, La Caixa Foundation LCF/BQ/IN17/11620019, EU: MSC program, Spain 101025085
Published: 2022
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66. How to (and How Not to) Get Married in Sixteenth-Century Venice (Selections from the Diaries of Marin Sanudo)

Author: Sanudo, Marin, Labalme, Patricia H., White, Laura Sanguineti, and Carroll, Linda
Published: 1999
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67. Transposable element expression with variation in sex chromosome number supports a toxic Y effect on human longevity

Author: Teoli, Jordan, primary, Fablet, Marie, additional, Bardel, Claire, additional, Necsulea, Anamaria, additional, Labalme, Audrey, additional, Lejeune, Hervé, additional, Lemaitre, Jean-François, additional, Gueyffier, François, additional, Sanlaville, Damien, additional, Vieira, Cristina, additional, Marais, Gabriel AB, additional, and Plotton, Ingrid, additional
Published: 2023
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68. Asparagine synthetase deficiency: A novel case with an unusual molecular mechanism

Author: Marie Faoucher, Anne-Lise Poulat, Nicolas Chatron, Audrey Labalme, Caroline Schluth-Bolard, Marianne Till, Christine Vianey-Saban, Vincent Des Portes, Patrick Edery, Damien Sanlaville, Gaëtan Lesca, and Cécile Acquaviva
Subjects: Medicine (General), R5-920, Biology (General), QH301-705.5
Abstract: We report the case of a girl with Asparagine synthetase deficiency, an autosomal recessive metabolic disorder characterized by severe microcephaly and epileptic encephalopathy secondary to pathogenic variants in the ASNS gene. Genetic explorations found a deletion of ASNS and a missense variant on the other allele detected respectively by array comparative genomic hybridization (CGH) and Sanger sequencing. Amino acid analysis provided a biochemical confirmation. Previous cases of Asparagine synthetase deficiency were diagnosed though exome Sequencing. The combination of several techniques (array CGH, sequencing, and biochemical analysis) improves the opportunity to provide accurate diagnosis. Keyswords: Asparagine synthetase deficiency, Microcephaly, Epileptic encephalopathy, Array CGH, Intragenic deletion, ASNS
Published: 2019
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69. Postnatal clinical phenotype of five patients with Pallister–Killian Syndrome (tetrasomy 12p): Interest of array CGH for diagnosis and review of the literature

Author: Amerh Salem Alqahtani, Audrey Putoux, Marie Noelle Bonnet Dupeyron, Maryline Carneiro, Laurence Lion‐Francois, Massimiliano Rossi, Hélène Tevissen, Caroline Schluth Bolard, Audrey Labalme, Gaetan Lesca, Marianne Till, Patrick Edery, and Damien Sanlaville
Subjects: aCGH, isochromosome 12p, Pallister–Killian syndrome, postnatal, tetrasomy 12p, Genetics, QH426-470
Abstract: Abstract Background Pallister–Killian syndrome (PKS) is a rare sporadic disorder caused by tetrasomy of the short arm of chromosome 12. The main clinical manifestations are global developmental delay, intellectual disability, epilepsy, dysmorphic features, hypopigmented and/or hyperpigmented lesions, and multiple congenital anomalies. PKS is associated with tissue mosaicism, which is difficult to diagnose through peripheral blood sample by conventional cytogenetic methods and fluorescence in situ hybridization. Methods Here, we report five patients with PKS. We delineate their clinical phenotypes and we compare them with previously published cases. We used array Comparative Genomic Hybridization (aCGH) with DNA extracted from peripheral blood samples. The five patients have also been tested by conventional cytogenetics techniques. Results Four out of five patients showed tetrasomy 12p by aCGH. Three of the four patients have typical i(12p) and one of the four demonstrated atypical tetrasomy 12p. The percentage of mosaicism was as low as 20%. Our cohort exhibited the typical PKS phenotypes. Conclusion Our results demonstrate the efficacy of aCGH for the diagnosis of PKS from DNA extracted from lymphocytes. Thus, for patients suspected of PKS, we recommend performing aCGH on lymphocytes at an early age before proceeding to skin biopsy. aCGH on peripheral blood samples is sensitive in detecting low level of mosaicism and it is less invasive method than skin biopsy. We reviewed also the literature concerning the previously published PKS patients diagnosed by aCGH.
Published: 2019
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70. The KM3NeT multi-PMT optical module

Author: Aiello, S., Albert, A., Alshamsi, M., Alves Garre, S., Aly, Z., Ambrosone, A., Ameli, F., Andre, M., Androulakis, G., Anghinolfi, M., Anguita, M., Ardid, M., Ardid, S., Aublin, J., Avgitas, T., Bagatelas, C., Bailly-Salins, L., Baret, B., Basegmez, S., Pree, Bendahman, M., Benfenati, F., Berbee, E., Den Berg, A. M., Bertin, V., Beveren, V., Biagi, S., Boer, R., Boettcher, M., Cabo, M. Bou, Boumaaza, J., Bouta, M., Bouwhuis, M., Bozza, C., Brânzaş, H., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Cacopardo, G., Caiffi, B., Calvo, D., Campion, S., Capone, A., Víctor Carretero, Castaldi, P., Celli, S., Chabab, M., Champion, C., Chau, N., Chen, A., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, Ai R., Coelho, J. A. B., Coleiro, A., Colomer Molla, M., Coniglione, R., Coyle, P., Creusot, A., Cruz, A., Cuttone, G., D Amato, C., D Amico, A., Dallier, R., Benedittis, A., Martino, B., Wasseige, G., Palma, I. Di, Díaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Dörr, M., Drakopoulou, Al E., Drouhin, D., Eberl, T., Eddyamoui, A., Eeden, T., Eijk, D., El Bojaddaini, I., Hedri, S. El, Enzenhöfer, A., Espinosa, V., Fermani, P., Ferrara, G., Filipović, M. D., Filippini, An F., Fransen, J., Fusco, L. A., Gajanana, D., Gal, T., García Méndez, J., Soto, A. García, Garufi, F., Gatelet, Y., Gatius Oliver, C., Geißelbrecht, N., Gialanella, L., Giorgio, E., Gozzini, S. R., Gracia, R., Graf, K., Grella, G., Grmek, A., Gromov, I., Guderian, D., Guidi, C., Guillon, B., Gutiérrez, M., Häfner, J., Haegel, L., Hallmann, S., Hamdaoui, H., Haren, H., Heijboer, A., Hekalo, A., Hennig, Al L., Hernández-Rey, J. J., Hofestädt, J., Huang, F., Idrissi Ibnsalih, W., Ilioni, A., Illuminati, G., James, C. W., Janezashvili, D., Jansweijer, P., Jong, M., Jong, P., Jung, B. J., Kalaczyński, P., Kalekin, O., Katz, U. F., Kayzel, F., Khan Chowdhury, N. R., Kistauri, G., Knaap, F., Kooijman, P., Koopstra, J., Kouchner, A., Kulikovskiy, V., Labalme, M., Lahmann, R., Lamoureux, M., Larosa, G., Lastoria, C., Lazo, A., Le Breton, R., Le Stum, S., Lehaut, G., Leonardi, O., Leone, F., Leonora, E., Lessing, N., Levi, G., Lincetto, M., Clark, M. Lindsey, Llorens Alvarez, C., Longhitano, F., Lopez-Coto, D., Maderer, L., Majumdar, J., Mańczak, J., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Martínez-Mora, J. A., Martini, A., Marzaioli, F., Mastroianni, S., Melis, K. W., Miele, G., Migliozzi, P., Migneco, E., Mijakowski, P., Miranda, L. S., Mollo, C. M., Mongelli, M., Moussa, Ai A., Muller, R., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Nkosi, B., Fearraigh, B. Ó, O Sullivan, M., Organokov, M., Orlando, A., Palacios González, J., Papalashvili, G., Papaleo, R., Passaro, G., Pastore, C., Păun, A. M., Păvălaş, G. E., Pellegrini, G., Pellegrino, C., Perrin-Terrin, M., Pestel, V., Piattelli, P., Pieterse, C., Pisanti, O., Poirè, C., Popa, V., Pradier, T., Probst, I., Pulvirenti, S., Quéméner, G., Randazzo, N., Razzaque, S., Real, D., Reck, S., Riccobene, G., Rocco, R., Romanov, A., Rovelli, A., Salesa Greus, F., Samtleben, D. F. E., Sánchez Losa, A., Sanguineti, M., Santonocito, D., Sapienza, P., Schmeitz, R., Schmelling, J., Schnabel, J., Schneider, M. F., Schumann, J., Schutte, H. M., Seneca, J., Sgura, I., Shanidze, Ai R., Sharma, A., Sinopoulou, A., Smirnov, M. V., Spisso, B., Spurio, M., Stavropoulos, D., Stellacci, S. M., Taiuti, M., Tatone, F., Tayalati, Ai Y., Tedjditi, H., Thiersen, H., Timmer, P., Tingay, S., Tsagkli, S., Tsourapis, V., Tzamariudaki, E., Tzanetatos, D., Valieri, C., Elewyck, V., Vasileiadis, G., Versari, F., Viola, S., Vivolo, D., Wilms, J., Wojaczyński, R., Wolf, E., Yousfi, T., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zúñiga, J., Zywucka, N., Aiello S., Albert A., Alshamsi M., Alves Garre S., Aly Z., Ambrosone A., Ameli F., Andre M., Androulakis G., Anghinolfi M., Anguita M., Ardid M., Ardid S., Aublin J., Avgitas T., Bagatelas C., Bailly-Salins L., Baret B., Basegmez Du Pree S., Bendahman M., Benfenati F., Berbee E., Van Den Berg A.M., Bertin V., Van Beveren V., Biagi S., De Boer R., Boettcher M., Bou Cabo M., Boumaaza J., Bouta M., Bouwhuis M., Bozza C., Branzas H., Bruijn R., Brunner J., Bruno R., Buis E., Buompane R., Busto J., Cacopardo G., Caiffi B., Calvo D., Campion S., Capone A., Carretero V., Castaldi P., Celli S., Chabab M., Champion C., Chau N., Chen A., Cherubini S., Chiarella V., Chiarusi T., Circella M., Cocimano R., Coelho J.A.B., Coleiro A., Colomer Molla M., Coniglione R., Coyle P., Creusot A., Cruz A., Cuttone G., D'Amato C., D'Amico A., Dallier R., De Benedittis A., De Martino B., De Wasseige G., Di Palma I., Diaz A.F., Diego-Tortosa D., Distefano C., Domi A., Donzaud C., Dornic D., Dorr M., Drakopoulou E., Drouhin D., Eberl T., Eddyamoui A., Van Eeden T., Van Eijk D., El Bojaddaini I., El Hedri S., Enzenhofer A., Espinosa V., Fermani P., Ferrara G., Filipovic M.D., Filippini F., Fransen J., Fusco L.A., Gajanana D., Gal T., Garcia Mendez J., Garcia Soto A., Garufi F., Gatelet Y., Gatius Oliver C., Geisselbrecht N., Gialanella L., Giorgio E., Gozzini S.R., Gracia R., Graf K., Grella G., Grmek A., Gromov I., Guderian D., Guidi C., Guillon B., Gutierrez M., Hafner J., Haegel L., Hallmann S., Hamdaoui H., Van Haren H., Heijboer A., Hekalo A., Hennig L., Hernandez-Rey J.J., Hofestadt J., Huang F., Idrissi Ibnsalih W., Ilioni A., Illuminati G., James C.W., Janezashvili D., Jansweijer P., De Jong M., De Jong P., Jung B.J., Kalaczynski P., Kalekin O., Katz U.F., Kayzel F., Khan Chowdhury N.R., Kistauri G., Van Der Knaap F., Kooijman P., Koopstra J., Kouchner A., Kulikovskiy V., Labalme M., Lahmann R., Lamoureux M., Larosa G., Lastoria C., Lazo A., Le Breton R., Le Stum S., Lehaut G., Leonardi O., Leone F., Leonora E., Lessing N., Levi G., Lincetto M., Lindsey Clark M., Llorens Alvarez C., Longhitano F., Lopez-Coto D., Maderer L., Majumdar J., Manczak J., Margiotta A., Marinelli A., Markou C., Martin L., Martinez-Mora J.A., Martini A., Marzaioli F., Mastroianni S., Melis K.W., Miele G., Migliozzi P., Migneco E., Mijakowski P., Miranda L.S., Mollo C.M., Mongelli M., Moussa A., Muller R., Musumeci M., Nauta L., Navas S., Nicolau C.A., Nkosi B., Fearraigh B.O., O'Sullivan M., Organokov M., Orlando A., Palacios Gonzalez J., Papalashvili G., Papaleo R., Passaro G., Pastore C., Paun A.M., Pavalas G.E., Pellegrini G., Pellegrino C., Perrin-Terrin M., Pestel V., Piattelli P., Pieterse C., Pisanti O., Poire C., Popa V., Pradier T., Probst I., Pulvirenti S., Quemener G., Randazzo N., Razzaque S., Real D., Reck S., Riccobene G., Rocco R., Romanov A., Rovelli A., Salesa Greus F., Samtleben D.F.E., Sanchez Losa A., Sanguineti M., Santonocito D., Sapienza P., Schmeitz R., Schmelling J., Schnabel J., Schneider M.F., Schumann J., Schutte H.M., Seneca J., Sgura I., Shanidze R., Sharma A., Sinopoulou A., Smirnov M.V., Spisso B., Spurio M., Stavropoulos D., Stellacci S.M., Taiuti M., Tatone F., Tayalati Y., Tedjditi H., Thiersen H., Timmer P., Tingay S., Tsagkli S., Tsourapis V., Tzamariudaki E., Tzanetatos D., Valieri C., Van Elewyck V., Vasileiadis G., Versari F., Viola S., Vivolo D., Wilms J., Wojaczynski R., De Wolf E., Yousfi T., Zavatarelli S., Zegarelli A., Zito D., Zornoza J.D., Zuniga J., Zywucka N., Groupe de Recherche en Physique des Hautes Energies (GRPHE), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-IUT de Colmar, Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Laboratoire Univers et Particules de Montpellier (LUPM), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), KM3NeT, Aiello, S., Albert, A., Alshamsi, M., Alves Garre, S., Aly, Z., Ambrosone, A., Ameli, F., Andre, M., Androulakis, G., Anghinolfi, M., Anguita, M., Ardid, M., Ardid, S., Aublin, J., Avgitas, T., Bagatelas, C., Bailly-Salins, L., Baret, B., Basegmez Du Pree, S., Bendahman, M., Benfenati, F., Berbee, E., Van Den Berg, A. M., Bertin, V., Van Beveren, V., Biagi, S., De Boer, R., Boettcher, M., Bou Cabo, M., Boumaaza, J., Bouta, M., Bouwhuis, M., Bozza, C., Branzas, H., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Cacopardo, G., Caiffi, B., Calvo, D., Campion, S., Capone, A., Carretero, V., Castaldi, P., Celli, S., Chabab, M., Champion, C., Chau, N., Chen, A., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Colomer Molla, M., Coniglione, R., Coyle, P., Creusot, A., Cruz, A., Cuttone, G., D'Amato, C., D'Amico, A., Dallier, R., De Benedittis, A., De Martino, B., De Wasseige, G., Di Palma, I., Diaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Dorr, M., Drakopoulou, E., Drouhin, D., Eberl, T., Eddyamoui, A., Van Eeden, T., Van Eijk, D., El Bojaddaini, I., El Hedri, S., Enzenhofer, A., Espinosa, V., Fermani, P., Ferrara, G., Filipovic, M. D., Filippini, F., Fransen, J., Fusco, L. A., Gajanana, D., Gal, T., Garcia Mendez, J., Garcia Soto, A., Garufi, F., Gatelet, Y., Gatius Oliver, C., Geisselbrecht, N., Gialanella, L., Giorgio, E., Gozzini, S. R., Gracia, R., Graf, K., Grella, G., Grmek, A., Gromov, I., Guderian, D., Guidi, C., Guillon, B., Gutierrez, M., Hafner, J., Haegel, L., Hallmann, S., Hamdaoui, H., Van Haren, H., Heijboer, A., Hekalo, A., Hennig, L., Hernandez-Rey, J. J., Hofestadt, J., Huang, F., Idrissi Ibnsalih, W., Ilioni, A., Illuminati, G., James, C. W., Janezashvili, D., Jansweijer, P., De Jong, M., De Jong, P., Jung, B. J., Kalaczynski, P., Kalekin, O., Katz, U. F., Kayzel, F., Khan Chowdhury, N. R., Kistauri, G., Van Der Knaap, F., Kooijman, P., Koopstra, J., Kouchner, A., Kulikovskiy, V., Labalme, M., Lahmann, R., Lamoureux, M., Larosa, G., Lastoria, C., Lazo, A., Le Breton, R., Le Stum, S., Lehaut, G., Leonardi, O., Leone, F., Leonora, E., Lessing, N., Levi, G., Lincetto, M., Lindsey Clark, M., Llorens Alvarez, C., Longhitano, F., Lopez-Coto, D., Maderer, L., Majumdar, J., Manczak, J., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Martinez-Mora, J. A., Martini, A., Marzaioli, F., Mastroianni, S., Melis, K. W., Miele, G., Migliozzi, P., Migneco, E., Mijakowski, P., Miranda, L. S., Mollo, C. M., Mongelli, M., Moussa, A., Muller, R., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Nkosi, B., Fearraigh, B. O., O'Sullivan, M., Organokov, M., Orlando, A., Palacios Gonzalez, J., Papalashvili, G., Papaleo, R., Passaro, G., Pastore, C., Paun, A. M., Pavalas, G. E., Pellegrini, G., Pellegrino, C., Perrin-Terrin, M., Pestel, V., Piattelli, P., Pieterse, C., Pisanti, O., Poire, C., Popa, V., Pradier, T., Probst, I., Pulvirenti, S., Quemener, G., Randazzo, N., Razzaque, S., Real, D., Reck, S., Riccobene, G., Rocco, R., Romanov, A., Rovelli, A., Salesa Greus, F., Samtleben, D. F. E., Sanchez Losa, A., Sanguineti, M., Santonocito, D., Sapienza, P., Schmeitz, R., Schmelling, J., Schnabel, J., Schneider, M. F., Schumann, J., Schutte, H. M., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Sinopoulou, A., Smirnov, M. V., Spisso, B., Spurio, M., Stavropoulos, D., Stellacci, S. M., Taiuti, M., Tatone, F., Tayalati, Y., Tedjditi, H., Thiersen, H., Timmer, P., Tingay, S., Tsagkli, S., Tsourapis, V., Tzamariudaki, E., Tzanetatos, D., Valieri, C., Van Elewyck, V., Vasileiadis, G., Versari, F., Viola, S., Vivolo, D., Wilms, J., Wojaczynski, R., De Wolf, E., Yousfi, T., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zuniga, J., Zywucka, N., Research unit Astroparticle Physics, Centre Tecnològic de Vilanova i la Geltrú, and Universitat Politècnica de Catalunya. LAB - Laboratori d'Aplicacions Bioacústiques
Subjects: Astrofísica, Physics - Instrumentation and Detectors, data acquisition, Physics::Instrumentation and Detectors, tube, water, Física::Física de partícules [Àrees temàtiques de la UPC], FOS: Physical sciences, radiation: induced, GeV, Physique [physics]/Physique [physics], model: production, optical, Cherenkov detectors, Large detector systems for particle and astroparticle physics, Neutrino detectors, Neutrins, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Instrumentation, Instrumentation and Methods for Astrophysics (astro-ph.IM), KM3NeT, Mathematical Physics, neutrino: interaction, background: suppression, glass, photomultiplier, Telescopis, photon, Astrophysics::Instrumentation and Methods for Astrophysics, Instrumentation and Detectors (physics.ins-det), radiation: Cherenkov, calibration, sensitivity, cascade, neutrino: detector, FISICA APLICADA, Large detector systems for particle and astroparticle physic, ddc:520, readout, sphere, Òptica -- Aparells i instruments, Astrophysics - Instrumentation and Methods for Astrophysics, Telescopes, Cherenkov detector
Abstract: The optical module of the KM3NeT neutrino telescope is an innovative multi-faceted large area photodetection module. It contains 31 three-inch photomultiplier tubes in a single 0.44m diameter pressure-resistant glass sphere. The module is a sensory device also comprising calibration instruments and electronics for power, readout and data acquisition. It is capped with a breakout-box with electronics for connection to an electro-optical cable for power and long-distance communication to the onshore control station. The design of the module was qualified for the first time in the deep sea in 2013. Since then, the technology has been further improved to meet requirements of scalability, cost-effectiveness and high reliability. The module features a sub-nanosecond timing accuracy and a dynamic range allowing the measurement of a single photon up to a cascade of thousands of photons, suited for the measurement of the Cherenkov radiation induced in water by secondary particles from interactions of neutrinos with energies in the range of GeV to PeV. A distributed production model has been implemented for the delivery of more than 6000 modules in the coming few years with an average production rate of more than 100 modules per month. In this paper a review is presented of the design of the multi-PMT KM3NeT optical module with a proven effective background suppression and signal recognition and sensitivity to the incoming direction of photons., French National Research Agency (ANR) ANR-15-CE31-0020 Centre National de la Recherche Scientifique (CNRS), Commission Europeenne (FEDER fund) Commission Europeenne (Marie Curie Program), Institut Universitaire de France (IUF), LabEx UnivEarthS ANR-10-LABX-0023 ANR-18-IDEX-0001, Paris Ile-de-France Region, France, Shota Rustaveli National Science Foundation of Georgia (SRNSFG), Georgia FR-18-1268, German Research Foundation (DFG), Greek Ministry of Development-GSRT, Istituto Nazionale di Fisica Nucleare (INFN), Ministero dell'Universita e della Ricerca (MIUR), PRIN 2017 program, Italy NAT-NET 2017W4HA7S, Ministry of Higher Education, Scientific Research and Innovation, Morocco, Arab Fund for Economic and Social Development, Nederlandse organisatie voor Wetenschappelk Onderzoek (NWO), the Netherlands, National Science Centre, Poland 2015/18/E/ST2/00758, National Authority for Scientific Research (ANCS), Romania, Ministerio de Ciencia, Innovacion, Investigacion y Universidades (MCIU): Programa Estatal de Generacion de Conocimiento PGC2018-096663-B-C41 PGC2018-096663-A C42 PGC2018-096663-B-C43 PGC2018-096663-B-C44, Center for Forestry Research & Experimentation (CIEF) PROMETEO/2020/019, Generalitat Valenciana: Grisolia program GRISOLIA/2018/119 GRISOLIA/2021/192 Generalitat Valenciana: GenT program CIDEGENT/2018/034 CIDEGENT/2019/043 CIDEGENT/2020/049 CIDEGENT/2021/023, Junta de Andalucia AFQM-053-UGR18, La Caixa Foundation LCF/BQ/IN17/11620019, EU: MSC program, Spain 101025085
Published: 2022
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71. KM3NeT broadcast optical data transport system

Author: S. Aiello, A. Albert, S. Alves Garre, Z. Aly, A. Ambrosone, F. Ameli, M. Andre, M. Anghinolfi, M. Anguita, M. Ardid, S. Ardid, J. Aublin, C. Bagatelas, L. Bailly-Salins, B. Baret, S. Basegmez du Pree, Y. Becherini, M. Bendahman, F. Benfenati, E. Berbee, V. Bertin, S. Biagi, M. Boettcher, M. Bou Cabo, J. Boumaaza, M. Bouta, M. Bouwhuis, C. Bozza, H. Brânzaş, R. Bruijn, J. Brunner, R. Bruno, E. Buis, R. Buompane, J. Busto, B. Caiffi, D. Calvo, S. Campion, A. Capone, F. Carenini, V. Carretero, P. Castaldi, S. Celli, L. Cerisy, M. Chabab, N. Chau, A. Chen, R. Cherkaoui El Moursli, S. Cherubini, V. Chiarella, T. Chiarusi, M. Circella, R. Cocimano, J.A.B. Coelho, A. Coleiro, R. Coniglione, P. Coyle, A. Creusot, A. Cruz, G. Cuttone, A. D'Amico, R. Dallier, Y. Darras, A. De Benedittis, B. De Martino, R. Del Burgo, I. Di Palma, A.F. Díaz, D. Diego-Tortosa, C. Distefano, A. Domi, C. Donzaud, D. Dornic, M. Dörr, E. Drakopoulou, D. Drouhin, T. Eberl, A. Eddyamoui, T. van Eeden, M. Eff, D. van Eijk, I. El Bojaddaini, S. El Hedri, A. Enzenhöfer, V. Espinosa, G. Ferrara, M.D. Filipović, F. Filippini, L.A. Fusco, J. Gabriel, T. Gal, J. García Méndez, A. Garcia Soto, F. Garufi, C. Gatius Oliver, N. Geißelbrecht, L. Gialanella, E. Giorgio, A. Girardi, I. Goos, S.R. Gozzini, R. Gracia, K. Graf, D. Guderian, C. Guidi, B. Guillon, M. Gutiérrez, L. Haegel, H. van Haren, A. Heijboer, A. Hekalo, L. Hennig, J.J. Hernández-Rey, F. Huang, W. Idrissi Ibnsalih, G. Illuminati, C.W. James, D. Janezashvili, M. de Jong, P. de Jong, B.J. Jung, P. Kalaczyński, O. Kalekin, U.F. Katz, N.R. Khan Chowdhury, G. Kistauri, F. van der Knaap, P. Kooijman, A. Kouchner, V. Kulikovskiy, M. Labalme, R. Lahmann, A. Lakhal, M. Lamoureux, G. Larosa, C. Lastoria, A. Lazo, R. Le Breton, S. Le Stum, G. Lehaut, E. Leonora, N. Lessing, G. Levi, S. Liang, M. Lindsey Clark, F. Longhitano, L. Maderer, J. Majumdar, J. Mańczak, A. Margiotta, A. Marinelli, C. Markou, L. Martin, J.A. Martínez-Mora, A. Martini, F. Marzaioli, M. Mastrodicasa, S. Mastroianni, K.W. Melis, S. Miccichè, G. Miele, P. Migliozzi, E. Migneco, P. Mijakowski, C.M. Mollo, L. Morales-Gallegos, C. Morley-Wong, A. Moussa, R. Muller, M.R. Musone, M. Musumeci, L. Nauta, S. Navas, C.A. Nicolau, B. Nkosi, B. Ó Fearraigh, A. Orlando, E. Oukacha, J. Palacios González, G. Papalashvili, R. Papaleo, E.J. Pastor Gomez, A.M. Păun, G.E. Păvălaş, C. Pellegrino, S. Peña Martínez, M. Perrin-Terrin, J. Perronnel, V. Pestel, P. Piattelli, O. Pisanti, C. Poirè, V. Popa, T. Pradier, S. Pulvirenti, G. Quéméner, U. Rahaman, N. Randazzo, S. Razzaque, I.C. Rea, D. Real, S. Reck, G. Riccobene, J. Robinson, A. Romanov, F. Salesa Greus, D.F.E. Samtleben, A. Sánchez Losa, M. Sanguineti, C. Santonastaso, D. Santonocito, P. Sapienza, A. Sathe, J. Schmelling, J. Schnabel, M.F. Schneider, J. Schumann, H. M. Schutte, J. Seneca, I. Sgura, R. Shanidze, A. Sharma, A. Simonelli, A. Sinopoulou, M.V. Smirnov, B. Spisso, M. Spurio, D. Stavropoulos, S.M. Stellacci, M. Taiuti, K. Tavzarashvili, Y. Tayalati, H. Tedjditi, H. Thiersen, S. Tsagkli, V. Tsourapis, E. Tzamariudaki, V. Van Elewyck, G. Vannoye, G. Vasileiadis, F. Versari, S. Viola, D. Vivolo, H. Warnhofer, J. Wilms, E. de Wolf, H. Yepes-Ramirez, T. Yousfi, S. Zavatarelli, A. Zegarelli, D. Zito, J.D. Zornoza, J. Zúñiga, N. Zywucka, Aiello, S., Albert, A., Alves Garre, S., Aly, Z., Ambrosone, A., Ameli, F., Andre, M., Anghinolfi, M., Anguita, M., Ardid, M., Ardid, S., Aublin, J., Bagatelas, C., Bailly-Salins, L., Baret, B., Basegmez du Pree, S., Becherini, Y., Bendahman, M., Benfenati, F., Berbee, E., Bertin, V., Biagi, S., Boettcher, M., Bou Cabo, M., Boumaaza, J., Bouta, M., Bouwhuis, M., Bozza, C., Brânzaş, H., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Caiffi, B., Calvo, D., Campion, S., Capone, A., Carenini, F., Carretero, V., Castaldi, P., Celli, S., Cerisy, L., Chabab, M., Chau, N., Chen, A., Cherkaoui El Moursli, R., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Coniglione, R., Coyle, P., Creusot, A., Cruz, A., Cuttone, G., D'Amico, A., Dallier, R., Darras, Y., De Benedittis, A., De Martino, B., Del Burgo, R., Di Palma, I., Díaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Dörr, M., Drakopoulou, E., Drouhin, D., Eberl, T., Eddyamoui, A., van Eeden, T., Eff, M., van Eijk, D., El Bojaddaini, I., El Hedri, S., Enzenhöfer, A., Espinosa, V., Ferrara, G., Filipović, M. D., Filippini, F., Fusco, L. A., Gabriel, J., Gal, T., García Méndez, J., Garcia Soto, A., Garufi, F., Gatius Oliver, C., Geißelbrecht, N., Gialanella, L., Giorgio, E., Girardi, A., Goos, I., Gozzini, S. R., Gracia, R., Graf, K., Guderian, D., Guidi, C., Guillon, B., Gutiérrez, M., Haegel, L., van Haren, H., Heijboer, A., Hekalo, A., Hennig, L., Hernández-Rey, J. J., Huang, F., Idrissi Ibnsalih, W., Illuminati, G., James, C. W., Janezashvili, D., de Jong, M., de Jong, P., Jung, B. J., Kalaczyński, P., Kalekin, O., Katz, U. F., Khan Chowdhury, N. R., Kistauri, G., van der Knaap, F., Kooijman, P., Kouchner, A., Kulikovskiy, V., Labalme, M., Lahmann, R., Lakhal, A., Lamoureux, M., Larosa, G., Lastoria, C., Lazo, A., Le Breton, R., Le Stum, S., Lehaut, G., Leonora, E., Lessing, N., Levi, G., Liang, S., Lindsey Clark, M., Longhitano, F., Maderer, L., Majumdar, J., Mańczak, J., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Martínez-Mora, J. A., Martini, A., Marzaioli, F., Mastrodicasa, M., Mastroianni, S., Melis, K. W., Miccichè, S., Miele, G., Migliozzi, P., Migneco, E., Mijakowski, P., Mollo, C. M., Morales-Gallegos, L., Morley-Wong, C., Moussa, A., Muller, R., Musone, M. R., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Nkosi, B., Ó Fearraigh, B., Orlando, A., Oukacha, E., Palacios González, J., Papalashvili, G., Papaleo, R., Pastor Gomez, E. J., Păun, A. M., Păvălaş, G. E., Pellegrino, C., Peña Martínez, S., Perrin-Terrin, M., Perronnel, J., Pestel, V., Piattelli, P., Pisanti, O., Poirè, C., Popa, V., Pradier, T., Pulvirenti, S., Quéméner, G., Rahaman, U., Randazzo, N., Razzaque, S., Rea, I. C., Real, D., Reck, S., Riccobene, G., Robinson, J., Romanov, A., Salesa Greus, F., Samtleben, D. F. E., Sánchez Losa, A., Sanguineti, M., Santonastaso, C., Santonocito, D., Sapienza, P., Sathe, A., Schmelling, J., Schnabel, J., Schneider, M. F., Schumann, J., M. Schutte, H., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Simonelli, A., Sinopoulou, A., Smirnov, M. V., Spisso, B., Spurio, M., Stavropoulos, D., Stellacci, S. M., Taiuti, M., Tavzarashvili, K., Tayalati, Y., Tedjditi, H., Thiersen, H., Tsagkli, S., Tsourapis, V., Tzamariudaki, E., Van Elewyck, V., Vannoye, G., Vasileiadis, G., Versari, F., Viola, S., Vivolo, D., Warnhofer, H., Wilms, J., de Wolf, E., Yepes-Ramirez, H., Yousfi, T., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zúñiga, J., Zywucka, N., Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Laboratoire Univers et Particules de Montpellier (LUPM), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), KM3NeT, Centre Tecnològic de Vilanova i la Geltrú, and Universitat Politècnica de Catalunya. LAB - Laboratori d'Aplicacions Bioacústiques
Subjects: Astrofísica, FOS: Physical sciences, Physique [physics]/Physique [physics], optical, Neutrins, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Instrumentation, Instrumentation and Methods for Astrophysics (astro-ph.IM), KM3NeT, Mathematical Physics, Detectors òptics, Optical detectors, Data Processing, Física [Àrees temàtiques de la UPC], Telescopis, Large detector systems for particle and astroparticle physics, Cherenkov detectors, Optics, neutrino: VHE, neutrino: UHE, neutrino: detector, Terms—time calibration, fibre, network, Astroparticle physics, Astrophysics - Instrumentation and Methods for Astrophysics, performance, Telescopes
Abstract: The optical data transport system of the KM3NeT neutrino telescope at the bottom of the Mediterranean Sea will provide more than 6000 optical modules in the detector arrays with a point-to-point optical connection to the control stations onshore. The ARCA and ORCA detectors of KM3NeT are being installed at a depth of about 3500m and 2500 m, respectively and their distance to the control stations is about 100 kilometers and 40 kilometers. In particular, the two detectors are optimised for the detection of cosmic neutrinos with energies above about 1 TeV (ARCA) and for the detection of atmospheric neutrinos with energies in the range 1 GeV–1 TeV (ORCA). The expected maximum data rate is 200 Mbps per optical module. The implemented optical data transport system matches the layouts of the networks of electro-optical cables and junction boxes in the deep sea. For efficient use of the fibres in the system the technology of Dense Wavelength Division Multiplexing is applied. The performance of the optical system in terms of measured bit error rates, optical budget are presented. The next steps in the implementation of the system are also discussed., Agence Nationale de la Recherche (contract ANR-15-CE31-0020), Centre National de la Recherche Scientifique (CNRS), Commission Européenne (FEDER fund and Marie Curie Program), Institut Universitaire de France (IUF), LabEx UnivEarthS (ANR-10-LABX-0023 and ANR-18-IDEX-0001), Paris Île-de-France Region, France; Deutsche Forschungsgemeinschaft (DFG), Germany; The General Secretariat of Research and Innovation (GSRI), Greece Istituto Nazionale di Fisica Nucleare (INFN), Ministero dell’Università e della Ricerca (MIUR), PRIN 2017 program (Grant NAT-NET 2017W4HA7S) Italy, Ministry of Higher Education, Scientific Research and Innovation, Morocco, and the Arab Fund for Economic and Social Development, Kuwait, Nederlandse organisatie voor Wetenschappel¼k Onderzoek (NWO), The National Science Centre, Poland (2021/41/N/ST2/01177), National Authority for Scientific Research (ANCS), Romania; Ministerio de Ciencia, Innovación, Investigación y Universidades (MCIU), Programa Estatal de Generación de Conocimiento (refs. PGC2018-096663-B-C41, A-C42, B-C43, B-C44, PID2021-124591NB-C41, C42, -C43), MCIU/FEDER, Generalitat Valenciana, Prometeo (PROMETEO/2020/019), Grisolía (refs. GRISOLIA/2018/119, /2021/192), GenT (refs. CIDEGENT/2018/034, /2019/043, /2020/049, /2021/023) programs, Junta de Andalucía (ref. A-FQM-053-UGR18), La Caixa Foundation (ref. LCF/BQ/IN17/11620019), EU: MSC program (ref. 101025085, Spain; María Zambrano program within the framework of grants for retaining in the Spanish university system (Spanish Ministry of Universities, The European Union, NextGenerationEU
Published: 2023
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72. Statistical method to compare massive parallel sequencing pipelines.

Author: M.-H. Elsensohn, N. Leblay, Sarra Dimassi, Amandine Campan-Fournier, A. Labalme, Florence Roucher Boulez, D. Sanlaville, Gaetan Lesca, C. Bardel, and Pascal Roy
Published: 2017
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73. Radiothérapie guidée par l’image pour les petits animaux : une nouvelle ère pour les études précliniques

Author: Delpon, G., Frelin-Labalme, A.-M., Heinrich, S., Beaudouin, V., Noblet, C., Begue, M., Le Deroff, C., Pouzoulet, F., and Chiavassa, S.
Published: 2016
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74. Site Isolation in Metal–Organic Layers Enhances Photoredox Gold Catalysis

Author: Haifeng Zheng, Yingjie Fan, Yang Song, Justin S. Chen, Eric You, Steven Labalme, and Wenbin Lin
Subjects: Photosensitizing Agents, Colloid and Surface Chemistry, Alkynes, Gold, General Chemistry, Alkenes, Biochemistry, Catalysis
Abstract: Herein, we report the synthesis of a metal-organic layer, Hf-Ru-Au, containing Ru(bipyridine)
Published: 2022
Full Text: View/download PDF

75. Implementation and first results of the KM3NeT real-time core-collapse supernova neutrino search

Author: KM3NeT Collaboration, Aiello, S., Albert, A., Alshamsi, M., Garre, S. Alves, Aly, Z., Ambrosone, A., Ameli, F., Andre, M., Androulakis, G., Anghinolfi, M., Anguita, M., Ardid, M., Ardid, S., Aublin, J., Bagatelas, C., Baret, B., Pree, S. Basegmez du, Bendahman, M., Benfenati, F., Berbee, E., Berg, A. M. van den, Bertin, V., Biagi, S., Boettcher, M., Cabo, M. Bou, Boumaaza, J., Bouta, M., Bouwhuis, M., Bozza, C., Brânzaş, H., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Caiffi, B., Calvo, D., Campion, S., Capone, A., Carretero, V., Castaldi, P., Celli, S., Chabab, M., Chau, N., Chen, A., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Molla, M. Colomer, Coniglione, R., Coyle, P., Creusot, A., Cruz, A., Cuttone, G., Dallier, R., De Martino, B., Di Palma, I., Díaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Dörr, M., Drouhin, D., Eberl, T., Eddyamoui, A., van Eeden, T., van Eijk, D., Bojaddaini, I. El, Hedri, S. El, Enzenhöfer, A., Espinosa, V., Fermani, P., Ferrara, G., Filipović, M. D., Filippini, F., Fusco, L. A., Gal, T., Méndez, J. García, Soto, A. Garcia, Garufi, F., Gatelet, Y., Oliver, C. Gatius, Geißelbrecht, N., Gialanella, L., Giorgio, E., Gozzini, S. R., Gracia, R., Graf, K., Grella, G., Guderian, D., Guidi, C., Guillon, B., Gutiérrez, M., Haefner, J., Hallmann, S., Hamdaoui, H., van Haren, H., Heijboer, A., Hekalo, A., Hennig, L., Hernández-Rey, J. J., Hofestädt, J., Huang, F., Ibnsalih, W. Idrissi, Illuminati, G., James, C. W., Janezashvili, D., de Jong, M., de Jong, P., Jung, B. J., Kalaczyński, P., Kalekin, O., Katz, U. F., Chowdhury, N. R. Khan, Kistauri, G., van der Knaap, F., Kooijman, P., Kouchner, A., Kulikovskiy, V., Labalme, M., Lahmann, R., Lamoureux, M., Larosa, G., Lastoria, C., Lazo, A., Breton, R. Le, Stum, S. Le, Lehaut, G., Leonardi, O., Leone, F., Leonora, E., Lessing, N., Levi, G., Lincetto, M., Clark, M. Lindsey, Lipreau, T., Alvarez, C. LLorens, Longhitano, F., Lopez-Coto, D., Maderer, L., Majumdar, J., Mańczak, J., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Martínez-Mora, J. A., Martini, A., Marzaioli, F., Mastroianni, S., Melis, K. W., Miele, G., Migliozzi, P., Migneco, E., Mijakowski, P., Miranda, L. S., Mollo, C. M., Moser, M., Moussa, A., Muller, R., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Nkosi, B., Fearraigh, B. Ó, O'Sullivan, M., Organokov, M., Orlando, A., González, J. Palacios, Papalashvili, G., Papaleo, R., P{ă}un, A. M., Păvălaş, G. E., Pellegrino, C., Perrin-Terrin, M., Pestel, V., Piattelli, P., Pieterse, C., Pisanti, O., Poirè, C., Popa, V., Pradier, T., Probst, I., Pulvirenti, S., Quéméner, G., Randazzo, N., Razzaque, S., Real, D., Reck, S., Riccobene, G., Romanov, A., Rovelli, A., Greus, F. Salesa, Samtleben, D. F. E., Losa, A. Sánchez, Sanguineti, M., Santonocito, D., Sapienza, P., Schnabel, J., Schneider, M. F., Schumann, J., Schutte, H. M., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Stellacci, S. M., Taiuti, M., Tayalati, Y., Thiersen, H., Tingay, S., Tsagkli, S., Tsourapis, V., Tzamariudaki, E., Tzanetatos, D., Van Elewyck, V., Vannoye, G., Vasileiadis, G., Versari, F., Viola, S., Vivolo, D., de Wasseige, G., Wilms, J., Wojaczyński, R., de Wolf, E., Yousfi, T., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zúñiga, J., Zywucka, N., Istituto Nazionale di Fisica Nucleare, Sezione di Catania (INFN), Università degli studi di Catania = University of Catania (Unict), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), KM3NeT Collaboration, ANR-15-CE31-0020,DAEMONS,Démonstration de la possibilité d'établir l'ordonnancement des masses de neutrinos dans la mer(2015), ANR-18-IDEX-0001,Université de Paris,Université de Paris(2018), ANR-10-LABX-0023,UnivEarthS,Earth - Planets - Universe: observation, modeling, transfer(2010), Aiello, S., Albert, A., Alshamsi, M., Alves Garre, S., Aly, Z., Ambrosone, A., Ameli, F., Andre, M., Androulakis, G., Anghinolfi, M., Anguita, M., Ardid, M., Ardid, S., Aublin, J., Bagatelas, C., Baret, B., Pree, S. Basegmez du, Bendahman, M., Benfenati, F., Berbee, E., Berg, A. M. van den, Bertin, V., Biagi, S., Boettcher, M., Cabo, M. Bou, Boumaaza, J., Bouta, M., Bouwhuis, M., Bozza, C., Brânzaş, H., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Caiffi, B., Calvo, D., Campion, S., Capone, A., Carretero, V., Castaldi, P., Celli, S., Chabab, M., Chau, N., Chen, A., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Molla, M. Colomer, Coniglione, R., Coyle, P., Creusot, A., Cruz, A., Cuttone, G., Dallier, R., De Martino, B., Palma, I. Di, Díaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Dörr, M., Drouhin, D., Eberl, T., Eddyamoui, A., Eeden, T. van, Eijk, D. van, Bojaddaini, I. El, Hedri, S. El, Enzenhöfer, A., Espinosa, V., Fermani, P., Ferrara, G., Filipović, M. D., Filippini, F., Fusco, L. A., Gal, T., Méndez, J. García, Soto, A. Garcia, Garufi, F., Gatelet, Y., Oliver, C. Gatiu, Geißelbrecht, N., Gialanella, L., Giorgio, E., Gozzini, S. R., Gracia, R., Graf, K., Grella, G., Guderian, D., Guidi, C., Guillon, B., Gutiérrez, M., Haefner, J., Hallmann, S., Hamdaoui, H., Haren, H. van, Heijboer, A., Hekalo, A., Hennig, L., Hernández-Rey, J. J., Hofestädt, J., Huang, F., Ibnsalih, W. Idrissi, Illuminati, G., James, C. W., Janezashvili, D., de Jong, M., de Jong, P., Jung, B. J., Kalaczyński, P., Kalekin, O., Katz, U. F., Chowdhury, N. R. Khan, Kistauri, G., Knaap, F. van der, Kooijman, P., Kouchner, A., Kulikovskiy, V., Labalme, M., Lahmann, R., Lamoureux, M., Larosa, G., Lastoria, C., Lazo, A., Breton, R. Le, Stum, S. Le, Lehaut, G., Leonardi, O., Leone, F., Leonora, E., Lessing, N., Levi, G., Lincetto, M., Clark, M. Lindsey, Lipreau, T., Alvarez, C. LLoren, Longhitano, F., Lopez-Coto, D., Maderer, L., Majumdar, J., Mańczak, J., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Martínez-Mora, J. A., Martini, A., Marzaioli, F., Mastroianni, S., Melis, K. W., Miele, G., Migliozzi, P., Migneco, E., Mijakowski, P., Miranda, L. S., Mollo, C. M., Moser, M., Moussa, A., Muller, R., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Nkosi, B., Fearraigh, B. Ó, O’Sullivan, M., Organokov, M., Orlando, A., González, J. Palacio, Papalashvili, G., Papaleo, R., Păun, A. M., Păvălaş, G. E., Pellegrino, C., Perrin-Terrin, M., Pestel, V., Piattelli, P., Pieterse, C., Pisanti, O., Poirè, C., Popa, V., Pradier, T., Probst, I., Pulvirenti, S., Quéméner, G., Randazzo, N., Razzaque, S., Real, D., Reck, S., Riccobene, G., Romanov, A., Rovelli, A., Greus, F. Salesa, Samtleben, D. F. E., Losa, A. Sánchez, Sanguineti, M., Santonocito, D., Sapienza, P., Schnabel, J., Schneider, M. F., Schumann, J., Schutte, H. M., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Stellacci, S. M., Taiuti, M., Tayalati, Y., Thiersen, H., Tingay, S., Tsagkli, S., Tsourapis, V., Tzamariudaki, E., Tzanetatos, D., Elewyck, V. Van, Vannoye, G., Vasileiadis, G., Versari, F., Viola, S., Vivolo, D., de Wasseige, G., Wilms, J., Wojaczyński, R., de Wolf, E., Yousfi, T., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zúñiga, J., Zywucka, N., Centre Tecnològic de Vilanova i la Geltrú, Universitat Politècnica de Catalunya. LAB - Laboratori d'Aplicacions Bioacústiques, KM3NeT (IHEF, IoP, FNWI), Astroparticle Physics (IHEF, IoP, FNWI), ATLAS (IHEF, IoP, FNWI), IoP (FNWI), Research unit Astroparticle Physics, S. Aiello, A. Albert, M. Alshamsi, S. Alves Garre, Z. Aly, A. Ambrosone, F. Ameli, M. Andre, G. Androulaki, M. Anghinolfi, M. Anguita, M. Ardid, S. Ardid, J. Aublin, C. Bagatela, B. Baret, S. Basegmez du Pree, M. Bendahman, F. Benfenati, E. Berbee, A. M. van den Berg, V. Bertin, S. Biagi, M. Boettcher, M. Bou Cabo, J. Boumaaza, M. Bouta, M. Bouwhui, C. Bozza, H. Br??nza??, R. Bruijn, J. Brunner, R. Bruno, E. Bui, R. Buompane, J. Busto, B. Caiffi, D. Calvo, S. Campion, A. Capone, V. Carretero, P. Castaldi, S. Celli, M. Chabab, N. Chau, A. Chen, S. Cherubini, V. Chiarella, T. Chiarusi, M. Circella, R. Cocimano, J. A. B. Coelho, A. Coleiro, M. Colomer Molla, R. Coniglione, P. Coyle, A. Creusot, A. Cruz, G. Cuttone, R. Dallier, B. De Martino, I. Di Palma, A. F. D??az, D. Diego-Tortosa, C. Distefano, A. Domi, C. Donzaud, D. Dornic, M. D??rr, D. Drouhin, T. Eberl, A. Eddyamoui, T. van Eeden, D. van Eijk, I. El Bojaddaini, S. El Hedri, A. Enzenh??fer, V. Espinosa, P. Fermani, G. Ferrara, M. D. Filipovi??, F. Filippini, L. A. Fusco, T. Gal, J. Garc??a M??ndez, A. Garcia Soto, F. Garufi, Y. Gatelet, C. Gatius Oliver, N. Gei??elbrecht, L. Gialanella, E. Giorgio, S. R. Gozzini, R. Gracia, K. Graf, G. Grella, D. Guderian, C. Guidi, B. Guillon, M. Guti??rrez, J. Haefner, S. Hallmann, H. Hamdaoui, H. van Haren, A. Heijboer, A. Hekalo, L. Hennig, J. J. Hern??ndez-Rey, J. Hofest??dt, F. Huang, W. Idrissi Ibnsalih, G. Illuminati, C. W. Jame, D. Janezashvili, M. de Jong, P. de Jong, B. J. Jung, P. Kalaczy??ski, O. Kalekin, U. F. Katz, N. R. Khan Chowdhury, G. Kistauri, F. van der Knaap, P. Kooijman, A. Kouchner, V. Kulikovskiy, M. Labalme, R. Lahmann, M. Lamoureux, G. Larosa, C. Lastoria, A. Lazo, R. Le Breton, S. Le Stum, G. Lehaut, O. Leonardi, F. Leone, E. Leonora, N. Lessing, G. Levi, M. Lincetto, M. Lindsey Clark, T. Lipreau, C. LLorens Alvarez, F. Longhitano, D. Lopez-Coto, L. Maderer, J. Majumdar, J. Ma??czak, A. Margiotta, A. Marinelli, C. Markou, L. Martin, J. A. Mart??nez-Mora, A. Martini, F. Marzaioli, S. Mastroianni, K. W. Meli, G. Miele, P. Migliozzi, E. Migneco, P. Mijakowski, L. S. Miranda, C. M. Mollo, M. Moser, A. Moussa, R. Muller, M. Musumeci, L. Nauta, S. Nava, C. A. Nicolau, B. Nkosi, B. ?? Fearraigh, M. O???Sullivan, M. Organokov, A. Orlando, J. Palacios Gonz??lez, G. Papalashvili, R. Papaleo, A. M. P??un, G. E. P??v??la??, C. Pellegrino, M. Perrin-Terrin, V. Pestel, P. Piattelli, C. Pieterse, O. Pisanti, C. Poir??, V. Popa, T. Pradier, I. Probst, S. Pulvirenti, G. Qu??m??ner, N. Randazzo, S. Razzaque, D. Real, S. Reck, G. Riccobene, A. Romanov, A. Rovelli, F. Salesa Greu, D. F. E. Samtleben, A. S??nchez Losa, M. Sanguineti, D. Santonocito, P. Sapienza, J. Schnabel, M. F. Schneider, J. Schumann, H. M. Schutte, J. Seneca, I. Sgura, R. Shanidze, A. Sharma, A. Sinopoulou, B. Spisso, M. Spurio, D. Stavropoulo, S. M. Stellacci, M. Taiuti, Y. Tayalati, H. Thiersen, S. Tingay, S. Tsagkli, V. Tsourapi, E. Tzamariudaki, D. Tzanetato, V. Van Elewyck, G. Vannoye, G. Vasileiadi, F. Versari, S. Viola, D. Vivolo, G. de Wasseige, J. Wilm, R. Wojaczy??ski, E. de Wolf, T. Yousfi, S. Zavatarelli, A. Zegarelli, D. Zito, J. D. Zornoza, J. Z????iga, N. Zywucka, European Commission, Ministerio de Ciencia e Innovación (España), Generalitat Valenciana, Agencia Estatal de Investigación (España), Ministerio de Economía y Competitividad (España), and Junta de Andalucía
Subjects: Astrofísica, [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], [PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Physics and Astronomy (miscellaneous), Core collapse SN, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, neutrino telescopes, FOS: Physical sciences, DATA-ACQUISITION SYSTEM, Physics, Particles & Fields, realtime supernova search, core-collapse supernova, Neutrino, Neutrinos, supernova neutrinos, Engineering (miscellaneous), KM3NeT, Core-colapse supernova, Instrumentation and Methods for Astrophysics (astro-ph.IM), Core-collapse supernova, High Energy Astrophysical Phenomena (astro-ph.HE), neutrino, Science & Technology, Physics, Astrophysics::Instrumentation and Methods for Astrophysics, neutrino telescope, neutrinos, Neutrino astrophysics, Supernova neutrinos, Supernovae, Core collapse SN, neutrinos, KM3NeT, Física::Astronomia i astrofísica [Àrees temàtiques de la UPC], FISICA APLICADA, Physical Sciences, High Energy Physics::Experiment, Neutrino telescopes, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: The authors acknowledge the financial support of the funding agencies: Agence Nationale de la Recherche (contract ANR-15-CE31-0020), Centre National de la Recherche Scientifique (CNRS), Commission Europeenne (FEDER fund and Marie Curie Program), Institut Universitaire de France (IUF), LabEx UnivEarthS (ANR-10-LABX-0023 and ANR-18-IDEX-0001), Paris ile-de-France Region, France; Shota Rustaveli National Science Foundation of Georgia (SRNSFG, FR-18-1268), Georgia; Deutsche Forschungsgemeinschaft (DFG), Germany; The General Secretariat of Research and Technology (GSRT), Greece; Istituto Nazionale di Fisica Nucleare (INFN), Ministero dell'Universita e della Ricerca (MIUR), PRIN 2017 program (Grant NAT-NET 2017W4HA7S) Italy; Ministry of Higher Education Scientific Research and Professional Training, ICTP through Grant AF-13, Morocco; Nederlandse organisatie voor Wetenschappelijk Onderzoek (NWO), the Netherlands; The National Science Centre, Poland (2015/18/E/ST2/00758); National Authority for Scientific Research (ANCS), Romania; Ministerio de Ciencia, Innovacion, Investigacion y Universidades (MCIU): Programa Estatal de Generacion de Conocimiento (refs. PGC2018-096663-B-C41, -A-C42, -B-C43, -B-C44) (MCIU/FEDER), Generalitat Valenciana: Prometeo (PROMETEO/2020/019), Grisolia (ref. GRISOLIA/2018/119) and GenT (refs. CIDEGENT/2018/034, /2019/043, /2020/049) programs, Junta de Andalucia (ref. A-FQM-053-UGR18), La Caixa Foundation (ref. LCF/BQ/IN17/11620019), EU: MSC program (ref. 101025085), Spain., The KM3NeT research infrastructure is unconstruction in the Mediterranean Sea. KM3NeT will study atmospheric and astrophysical neutrinos with two multipurpose neutrino detectors, ARCA and ORCA, primarily aimed at GeV–PeV neutrinos. Thanks to the multiphotomultiplier tube design of the digital optical modules, KM3NeT is capable of detecting the neutrino burst from a Galactic or near-Galactic core-collapse supernova. This potential is already exploitable with the first detection units deployed in the sea. This paper describes the real-time implementation of the supernova neutrino search, operating on the two KM3NeT detectors since the first months of 2019. A quasi-online astronomy analysis is introduced to study the time profile of the detected neutrinos for especially significant events. Themechanism of generation and distribution of alerts, aswell as the integration into theSNEWSandSNEWS 2.0 global alert systems, are described. The approach for the follow-up of external alerts with a search for a neutrino excess in the archival data is defined. Finally, an overviewof the current detector capabilities and a report after the first two years of operation are given., French National Research Agency (ANR), European Commission ANR-15-CE31-0020, Centre National de la Recherche Scientifique (CNRS), Commission Europeenne, Institut Universitaire de France (IUF), LabEx UnivEarthS ANR-10-LABX-0023 ANR-18-IDEX-0001, Shota Rustaveli National Science Foundation of Georgia (SRNSFG), Georgia FR-18-1268, German Research Foundation (DFG), Greek Ministry of Development-GSRT, Istituto Nazionale di Fisica Nucleare (INFN), Ministry of Education, Universities and Research (MIUR), PRIN 2017 program, Italy NAT-NET 2017W4HA7S, Ministry of Higher Education Scientific Research and Professional Training, ICTP, Morocco AF-13, Netherlands Organization for Scientific Research (NWO) Netherlands Government, National Science Centre, Poland 2015/18/E/ST2/00758, National Authority for Scientific Research (ANCS), Romania, Ministerio de Ciencia, Innovacion, Investigacion y Universidades (MCIU): Programa Estatal de Generacion de Conocimiento PGC2018-096663-B-C41 PGC2018-096663-A-C42 PGC2018-096663-B-C43 PGC2018-096663-B-C44, Generalitat Valenciana PROMETEO/2020/019, Grisolia program GRISOLIA/2018/119 CIDEGENT/2018/034, Junta de Andalucia A-FQM-053-UGR18, La Caixa Foundation LCF/BQ/IN17/11620019, EU: MSC program 101025085, Paris Ile-de-France Region, France, GenT program CIDEGENT/2018/034 CIDEGENT/2019/043 CIDEGENT/2020/049
Published: 2022
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76. A genome-wide DNA methylation signature for SETD1B-related syndrome

Author: Krzyzewska, I. M., Maas, S. M., Henneman, P., Lip, K. v. d., Venema, A., Baranano, K., Chassevent, A., Aref-Eshghi, E., van Essen, A. J., Fukuda, T., Ikeda, H., Jacquemont, M., Kim, H.-G., Labalme, A., Lewis, S. M. E., Lesca, G., Madrigal, I., Mahida, S., Matsumoto, N., Rabionet, R., Rajcan-Separovic, E., Qiao, Y., Sadikovic, B., Saitsu, H., Sweetser, D. A., Alders, M., and Mannens, M. M. A. M.
Published: 2019
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77. Probing invisible neutrino decay with KM3NeT-ORCA

Author: Agence Nationale de la Recherche (France), Centre National de la Recherche Scientifique (France), Istituto Nazionale di Fisica Nucleare, Ministerio de Ciencia, Innovación y Universidades (España), Generalitat Valenciana, Junta de Andalucía, #NODATA#, KM3NeT Collaboration, Aiello, S., Albert, A., Alves Garre, S., Aly, Z., Ambrosone, A., Ameli, F., Andre, M., Anghinolfi, M., Anguita, M., Ardid, M., Ardid, S., Aublin, J., Bagatelas, C., Bailly-Salins, L., Baret, B., Basegmez du Pree, S., Becherini, Y., Bendahman, M., Benfenati, F., Berbee, E., Bertin, V., Biagi, S., Boettcher, M., Bou-Cabo, Manuel, Boumaaza, J., Bouta, M., Bouwhuis, M., Bozza, C., Brânzaş, H., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Caiffi, B., Calvo, D., Campion, S., Capone, A., Carenini, F., Carretero, V., Castaldi, P., Celli, S., Cerisy, L., Chabab. M., Chau, N., Chen, A. A., Cherkaoui El Moursli, R., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Coniglione, R., Coyle, P., Creusot, A., Cruz, A., Cuttone, G., Dallier, R., Darras, Y., De Benedittis. A., De Martino, B., Decoene, V., Del Burgo, R., Di Palma, I., Díaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Dörr. M., Drakopoulou, E., Drouhin, D., Eberl, T., Eddyamoui, A., van Eeden, T., Eff, M., van Eijk, D., El Bojaddaini, I., El Hedri, S., Enzenhöfer, A., Espinosa, V., Ferrara, G., Filipović, M. D., Filippini, F., Fusco, L. A., Gabriel, J., Gal, T., García Méndez, J., Garcia Soto, A., Garufi, F., Gatius Oliver, C., Geißelbrecht, N., Gialanella, L., Giorgio, E., Girardi, A., Goos, I., Gozzini, S. R., Gracia, R., Graf, K., Guderian, D., Guidi, C., Guillon, B., Gutiérrez, M., Haegel, L., van Haren, H., Heijboer, A., Hekalo, A., Hennig, L., Hernández-Rey, J. J., Huang, F., Idrissi Ibnsalih, W., Illuminati, G., James, C. W., Janezashvili, D., Jong, M. de, Jong, P. de, Jung, B. J., Kalaczyński, P., Kalekin, O., Katz, U. F., Khan Chowdhury, N. R., Kistauri, G., van der Knaap, F., Kooijman, P., Kouchner, A., Kulikovskiy, V., Labalme, M., Lahmann, R., Lakhal, A., Lamoureux, M., Larosa, G., Lastoria, C., Lazo, A., Le Breton, R., Le Stum, S., Lehaut, G., Leonora, E., Lessing, N., Levi, G., Liang, S., Lindsey Clark, M., Longhitano, F., Maderer, L., Majumdar, J., Mańczak, J., Margiotta. A., Marinelli, A., Markou, C., Martin, L., Martìnez-Mora, J. A., Martini, A., Marzaioli, F., Mastrodicasa. M., Mastroianni, S., Melis, K. W., Miccichè, S., Miele, G., Migliozzi, P., Migneco, E., Mijakowski, P., Mollo, C. M., Morales-Gallegos, L., Morley-Wong, C., Moussa, A., Muller, R., Musone, M. R., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Nkosi, B., Ó Fearraigh, B., Orlando, A., Oukacha, E., Palacios González, J., Papalashvili, G., Papaleo, R., Pastor Gómez, E. J., Păun, A. M., Păvălaş, G. E., Pellegrino, C., Peña Martínez, S., Perrin-Terrin, M., Perronnel, J., Pestel, V., Piattelli, P., Pisanti, O., Poirè, C., Popa, V., Pradier, T., Pulvirenti, S., Quéméner, G., Rahaman, U., Randazzo, N., Razzaque, S., Rea, I. C., Real, D., Reck, S., Riccobene, G., Robinson, J., Romanov, A., Salesa Greus, Francisco, Samtleben, D. F. E., Sánchez Losa, A., Sanguineti, M., Santonastaso, C., Santonocito, D., Sapienza, P., Sathe, A., Schnabel, J., Schneider, M. F., Schumann, J., Schutte, H. M., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Simonelli, A., Sinopoulou, A., Smirnov, M. V., Spisso, B., Spurio, M., Stavropoulos, D., Stellacci, S. M., Taiuti, M., Tavzarashvili, K., Tayalati, Y., Tedjditi, H., Thakore, T., Thiersen, H., Tsagkli, S., Tsourapis, V., Tzamariudaki, E., Van Elewyck, V., Vannoye, G., Vasileiadis, G., Versari, F., Viola, S., Vivolo, D., Warnhofer, H., Wilms, J., de Wolf, E., Yepes-Ramirez, H., Yousfi, T., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zúñiga, J., Zywucka, N., Agence Nationale de la Recherche (France), Centre National de la Recherche Scientifique (France), Istituto Nazionale di Fisica Nucleare, Ministerio de Ciencia, Innovación y Universidades (España), Generalitat Valenciana, Junta de Andalucía, #NODATA#, KM3NeT Collaboration, Aiello, S., Albert, A., Alves Garre, S., Aly, Z., Ambrosone, A., Ameli, F., Andre, M., Anghinolfi, M., Anguita, M., Ardid, M., Ardid, S., Aublin, J., Bagatelas, C., Bailly-Salins, L., Baret, B., Basegmez du Pree, S., Becherini, Y., Bendahman, M., Benfenati, F., Berbee, E., Bertin, V., Biagi, S., Boettcher, M., Bou-Cabo, Manuel, Boumaaza, J., Bouta, M., Bouwhuis, M., Bozza, C., Brânzaş, H., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Caiffi, B., Calvo, D., Campion, S., Capone, A., Carenini, F., Carretero, V., Castaldi, P., Celli, S., Cerisy, L., Chabab. M., Chau, N., Chen, A. A., Cherkaoui El Moursli, R., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Coniglione, R., Coyle, P., Creusot, A., Cruz, A., Cuttone, G., Dallier, R., Darras, Y., De Benedittis. A., De Martino, B., Decoene, V., Del Burgo, R., Di Palma, I., Díaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Dörr. M., Drakopoulou, E., Drouhin, D., Eberl, T., Eddyamoui, A., van Eeden, T., Eff, M., van Eijk, D., El Bojaddaini, I., El Hedri, S., Enzenhöfer, A., Espinosa, V., Ferrara, G., Filipović, M. D., Filippini, F., Fusco, L. A., Gabriel, J., Gal, T., García Méndez, J., Garcia Soto, A., Garufi, F., Gatius Oliver, C., Geißelbrecht, N., Gialanella, L., Giorgio, E., Girardi, A., Goos, I., Gozzini, S. R., Gracia, R., Graf, K., Guderian, D., Guidi, C., Guillon, B., Gutiérrez, M., Haegel, L., van Haren, H., Heijboer, A., Hekalo, A., Hennig, L., Hernández-Rey, J. J., Huang, F., Idrissi Ibnsalih, W., Illuminati, G., James, C. W., Janezashvili, D., Jong, M. de, Jong, P. de, Jung, B. J., Kalaczyński, P., Kalekin, O., Katz, U. F., Khan Chowdhury, N. R., Kistauri, G., van der Knaap, F., Kooijman, P., Kouchner, A., Kulikovskiy, V., Labalme, M., Lahmann, R., Lakhal, A., Lamoureux, M., Larosa, G., Lastoria, C., Lazo, A., Le Breton, R., Le Stum, S., Lehaut, G., Leonora, E., Lessing, N., Levi, G., Liang, S., Lindsey Clark, M., Longhitano, F., Maderer, L., Majumdar, J., Mańczak, J., Margiotta. A., Marinelli, A., Markou, C., Martin, L., Martìnez-Mora, J. A., Martini, A., Marzaioli, F., Mastrodicasa. M., Mastroianni, S., Melis, K. W., Miccichè, S., Miele, G., Migliozzi, P., Migneco, E., Mijakowski, P., Mollo, C. M., Morales-Gallegos, L., Morley-Wong, C., Moussa, A., Muller, R., Musone, M. R., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Nkosi, B., Ó Fearraigh, B., Orlando, A., Oukacha, E., Palacios González, J., Papalashvili, G., Papaleo, R., Pastor Gómez, E. J., Păun, A. M., Păvălaş, G. E., Pellegrino, C., Peña Martínez, S., Perrin-Terrin, M., Perronnel, J., Pestel, V., Piattelli, P., Pisanti, O., Poirè, C., Popa, V., Pradier, T., Pulvirenti, S., Quéméner, G., Rahaman, U., Randazzo, N., Razzaque, S., Rea, I. C., Real, D., Reck, S., Riccobene, G., Robinson, J., Romanov, A., Salesa Greus, Francisco, Samtleben, D. F. E., Sánchez Losa, A., Sanguineti, M., Santonastaso, C., Santonocito, D., Sapienza, P., Sathe, A., Schnabel, J., Schneider, M. F., Schumann, J., Schutte, H. M., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Simonelli, A., Sinopoulou, A., Smirnov, M. V., Spisso, B., Spurio, M., Stavropoulos, D., Stellacci, S. M., Taiuti, M., Tavzarashvili, K., Tayalati, Y., Tedjditi, H., Thakore, T., Thiersen, H., Tsagkli, S., Tsourapis, V., Tzamariudaki, E., Van Elewyck, V., Vannoye, G., Vasileiadis, G., Versari, F., Viola, S., Vivolo, D., Warnhofer, H., Wilms, J., de Wolf, E., Yepes-Ramirez, H., Yousfi, T., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zúñiga, J., and Zywucka, N.
Abstract: In the era of precision measurements of the neutrino oscillation parameters, upcoming neutrino experiments will also be sensitive to physics beyond the Standard Model. KM3NeT/ORCA is a neutrino detector optimised for measuring atmospheric neutrinos from a few GeV to around 100 GeV. In this paper, the sensitivity of the KM3NeT/ORCA detector to neutrino decay has been explored. A three-flavour neutrino oscillation scenario, where the third neutrino mass state $\nu_3$ decays into an invisible state, e.g. a sterile neutrino, is considered. We find that KM3NeT/ORCA would be sensitive to invisible neutrino decays with $1/\alpha_3=\tau_3/m_3 < 180$~$\mathrm{ps/eV}$ at $90\%$ confidence level, assuming true normal ordering. Finally, the impact of neutrino decay on the precision of KM3NeT/ORCA measurements for $\theta_{23}$, $\Delta m^2_{31}$ and mass ordering have been studied. No significant effect of neutrino decay on the sensitivity to these measurements has been found.
Published: 2023

78. The Power Board of the KM3NeT Digital Optical Module: design, upgrade, and production

Author: Aiello, S., Albert, A., Garre, S. Alves, Aly, Z., Ambrosone, A., Ameli, F., Andre, M., Androutsou, E., Anguita, M., Aphecetche, L., Ardid, M., Ardid, S., Atmani, H., Aublin, J., Badaracco, F., Bailly-Salins, L., Bardacova, Z., Baret, B., Quintana, A. Bariego, Pree, S. Basegmez du, Becherini, Y., Bendahman, M., Benfenati, F., Benhassi, M., Benoit, D. M., Berbee, E., Bertin, V., van Beveren, V., Biagi, S., Boettcher, M., Bonanno, D., Boumaaza, J., Bouta, M., Bouwhuis, M., Bozza, C., Bozza, R. M., Branzas, H., Bretaudeau, F., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Caiffi, B., Calvo, D., Campion, S., Capone, A., Careniniu, F., Carretero, V., Cartraud, T., Castaldi, P., Cecchini, V., Celli, S., Cerisy, L., Chabab, M., Chadolias, M., Champion, C., Chena, A., Cherubini, S., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Colonges, S., Coniglione, R., Coyle, P., Creusot, A., Cuttone, G., Dallier, R., Darras, Y., De Benedittis, A., De Martino, B., Decoene, V., Del Burgo, R., Del Rosso, I., Di Cerbo, U. M., Di Mauro, L. S., Di Palma, I., Díaz, A. F., Diaz, C., Diego-Tortosa, D., Distefano, C., Domia, A., Donzaud, C., Dornic, D., Dorra, M., Drakopoulou, E., Drouhin, D., Dvornicky, R., Eberla, T., Eckerova, E., Eddymaoui, A., van Eeden, T., Eff, M., van Eijk, D., Bojaddaini, I. El, Hedri, S. El, Enzenhofer, A., Ferrara, G., Filipovica, M. D., Filippini, F., Franciotti, D., Fusco, L. A., Gabellaa, O., Gabriela, J., Gagliardini, S., Gal, T., Mendez, J. Garcıa, Soto, A. Garcia, Oliver, C. Gatius, Geißelbrecht, N., Ghaddari, H., Gialanella, L., Gibson, B. K., Giorgio, E., Goos, I., Goswami, P., Goupilliere, D., Gozzini, S. R., Gracia, R., Grafa, K., Guidi, C., Guillon, B., Gutierrez, M., van Haren, H., Heijboer, A., Hekalo, A., Henniga, L., Hernandez-Rey, J. J., Ibnsalih, W. Idrissi, Illuminati, G., Jansweijer, P., de Jonga, M., de Jonga, P., Jung, B. J., Kalaczynski, P., Kalekin, O., Katz, U. F., Khatun, A., Kistauri, G., Kopper, C., Kouchner, A., Kueviakoe, V., Kulikovskiy, V., Kvatadze, R., Labalme, M., Lahmann, R., Larosa, G., Lastoria, C., Lazo, A., Stum, S. Le, Lehaut, G., Leonora, E., Lessing, N., Levi, G., Clark, M. Lindsey, Litrico, P., Longhitano, F., Majumdar, J., Malerba, L., Mamedov, F., Manczak, J., Manfredae, A., Marconi, M., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Martınez-Mora, J. A., Marzaioli, F., Mastrodicasa, M., Mastroianni, S., Miccich, S., Miele, G., Migliozzi, P., Migneco, E., Minutoli, S., Mitsou, M. L., Mollo, C. M., Morales-Gallegos, L., Morga, M., Moussa, A., Mateo, I. Mozun, Muller, R., Musico, P., Musone, M. R., Musumeci, M., Navas, S., Nayerhoda, A., Nicolau, C. A., Nkosi, B., Fearraigh, B. O., Oliviero, V., Orlando, A., Oukacha, E., Paesani, D., Gonzalez, J. Palacios, Papalashvili, G., Parisi, V., Gomez, E. J. Pastor, Pauna, A. M., Pavalas, G. E., Pellegrini, G., Martinez, S. Peñaa, Perrin-Terrin, M., Perronnel, J., Pestel, V., Pestes, R., Piattelli, P., Poirre, C., Popa, V., Pradier, T., Prado, J., Pulvirenti, S., Quemener, G., Quiroz-Rangel, C. A., Rahaman, U., Randazzo, N., Randriatoamana, R., Razzaque, S., Rea, I. C., Real, D., Riccobene, G., Robinson, J., Romanov, A., Saina, A., Greus, F. Salesa, Samtleben, D. F. E., Losa, A. Sanchez, Sanfilippo, S., Sanguineti, M., Santonastaso, C., Santonocito, D., Sapienza, P., Schmelling, J., Schnabel, J., Schumann, J., Schutt, H. M., Seneca, J., Sennan, N., Setter, B., Sgura, I., Shanidze, R., Sharma, A., Shitov, Y., Simkovic, F., Simonelli, A., Sinopoulou, A., Smirnov, M. V., Spisso, B., Spurio, M., Stavropoulos, D., Stekl, I., Taiuti, M., Tayalati, Y., Thiersen, H., Melo, I. Tosta e, Tragi, E., Trocme, B., Tsourapis, V., Tzamariudaki, E., Vacheret, A., Melchor, A. Valer, Valsecchi, V., Van Elewyck, V., Vannoye, G., Vasileiadis, G., de Sola, F. Vazquez, Verilhac, C., Veutro, A., Viola, S., Vivolo, D., Wilms, J., de Wolf, E., Ramirez, H. Yepes, Zarpapis, G., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zuniga, J., Zywuck, N., Aiello, S., Albert, A., Garre, S. Alves, Aly, Z., Ambrosone, A., Ameli, F., Andre, M., Androutsou, E., Anguita, M., Aphecetche, L., Ardid, M., Ardid, S., Atmani, H., Aublin, J., Badaracco, F., Bailly-Salins, L., Bardacova, Z., Baret, B., Quintana, A. Bariego, Pree, S. Basegmez du, Becherini, Y., Bendahman, M., Benfenati, F., Benhassi, M., Benoit, D. M., Berbee, E., Bertin, V., van Beveren, V., Biagi, S., Boettcher, M., Bonanno, D., Boumaaza, J., Bouta, M., Bouwhuis, M., Bozza, C., Bozza, R. M., Branzas, H., Bretaudeau, F., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Caiffi, B., Calvo, D., Campion, S., Capone, A., Careniniu, F., Carretero, V., Cartraud, T., Castaldi, P., Cecchini, V., Celli, S., Cerisy, L., Chabab, M., Chadolias, M., Champion, C., Chena, A., Cherubini, S., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Colonges, S., Coniglione, R., Coyle, P., Creusot, A., Cuttone, G., Dallier, R., Darras, Y., De Benedittis, A., De Martino, B., Decoene, V., Del Burgo, R., Del Rosso, I., Di Cerbo, U. M., Di Mauro, L. S., Di Palma, I., Díaz, A. F., Diaz, C., Diego-Tortosa, D., Distefano, C., Domia, A., Donzaud, C., Dornic, D., Dorra, M., Drakopoulou, E., Drouhin, D., Dvornicky, R., Eberla, T., Eckerova, E., Eddymaoui, A., van Eeden, T., Eff, M., van Eijk, D., Bojaddaini, I. El, Hedri, S. El, Enzenhofer, A., Ferrara, G., Filipovica, M. D., Filippini, F., Franciotti, D., Fusco, L. A., Gabellaa, O., Gabriela, J., Gagliardini, S., Gal, T., Mendez, J. Garcıa, Soto, A. Garcia, Oliver, C. Gatius, Geißelbrecht, N., Ghaddari, H., Gialanella, L., Gibson, B. K., Giorgio, E., Goos, I., Goswami, P., Goupilliere, D., Gozzini, S. R., Gracia, R., Grafa, K., Guidi, C., Guillon, B., Gutierrez, M., van Haren, H., Heijboer, A., Hekalo, A., Henniga, L., Hernandez-Rey, J. J., Ibnsalih, W. Idrissi, Illuminati, G., Jansweijer, P., de Jonga, M., de Jonga, P., Jung, B. J., Kalaczynski, P., Kalekin, O., Katz, U. F., Khatun, A., Kistauri, G., Kopper, C., Kouchner, A., Kueviakoe, V., Kulikovskiy, V., Kvatadze, R., Labalme, M., Lahmann, R., Larosa, G., Lastoria, C., Lazo, A., Stum, S. Le, Lehaut, G., Leonora, E., Lessing, N., Levi, G., Clark, M. Lindsey, Litrico, P., Longhitano, F., Majumdar, J., Malerba, L., Mamedov, F., Manczak, J., Manfredae, A., Marconi, M., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Martınez-Mora, J. A., Marzaioli, F., Mastrodicasa, M., Mastroianni, S., Miccich, S., Miele, G., Migliozzi, P., Migneco, E., Minutoli, S., Mitsou, M. L., Mollo, C. M., Morales-Gallegos, L., Morga, M., Moussa, A., Mateo, I. Mozun, Muller, R., Musico, P., Musone, M. R., Musumeci, M., Navas, S., Nayerhoda, A., Nicolau, C. A., Nkosi, B., Fearraigh, B. O., Oliviero, V., Orlando, A., Oukacha, E., Paesani, D., Gonzalez, J. Palacios, Papalashvili, G., Parisi, V., Gomez, E. J. Pastor, Pauna, A. M., Pavalas, G. E., Pellegrini, G., Martinez, S. Peñaa, Perrin-Terrin, M., Perronnel, J., Pestel, V., Pestes, R., Piattelli, P., Poirre, C., Popa, V., Pradier, T., Prado, J., Pulvirenti, S., Quemener, G., Quiroz-Rangel, C. A., Rahaman, U., Randazzo, N., Randriatoamana, R., Razzaque, S., Rea, I. C., Real, D., Riccobene, G., Robinson, J., Romanov, A., Saina, A., Greus, F. Salesa, Samtleben, D. F. E., Losa, A. Sanchez, Sanfilippo, S., Sanguineti, M., Santonastaso, C., Santonocito, D., Sapienza, P., Schmelling, J., Schnabel, J., Schumann, J., Schutt, H. M., Seneca, J., Sennan, N., Setter, B., Sgura, I., Shanidze, R., Sharma, A., Shitov, Y., Simkovic, F., Simonelli, A., Sinopoulou, A., Smirnov, M. V., Spisso, B., Spurio, M., Stavropoulos, D., Stekl, I., Taiuti, M., Tayalati, Y., Thiersen, H., Melo, I. Tosta e, Tragi, E., Trocme, B., Tsourapis, V., Tzamariudaki, E., Vacheret, A., Melchor, A. Valer, Valsecchi, V., Van Elewyck, V., Vannoye, G., Vasileiadis, G., de Sola, F. Vazquez, Verilhac, C., Veutro, A., Viola, S., Vivolo, D., Wilms, J., de Wolf, E., Ramirez, H. Yepes, Zarpapis, G., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zuniga, J., and Zywuck, N.
Abstract: The KM3NeT Collaboration is building an underwater neutrino observatory at the bottom of the Mediterranean Sea consisting of two neutrino telescopes, both composed of a three-dimensional array of light detectors, known as digital optical modules. Each digital optical module contains a set of 31 three inch photomultiplier tubes distributed over the surface of a 0.44 m diameter pressure-resistant glass sphere. The module includes also calibration instruments and electronics for power, readout and data acquisition. The power board was developed to supply power to all the elements of the digital optical module. The design of the power board began in 2013, and several prototypes were produced and tested. After an exhaustive validation process in various laboratories within the KM3NeT Collaboration, a mass production batch began, resulting in the construction of over 1200 power boards so far. These boards were integrated in the digital optical modules that have already been produced and deployed, 828 until October 2023. In 2017, an upgrade of the power board, to increase reliability and efficiency, was initiated. After the validation of a pre-production series, a production batch of 800 upgraded boards is currently underway. This paper describes the design, architecture, upgrade, validation, and production of the power board, including the reliability studies and tests conducted to ensure the safe operation at the bottom of the Mediterranean Sea throughout the observatory's lifespan
Published: 2023

79. Molecular and Phenotypic Characterization of the RORB-Related Disorder.

Author: Gokce-Samar, Zeynep, Vetro, Annalisa, De Bellescize, Julitta, Pisano, Tiziana, Monteiro, Laloe, Korff, Noémie Penaud ;Christian M., Fluss, Joel, Marini, Carla, Cesaroni, Elisabetta, Alvarez, Blanca Mercedes, Sanlaville, Damien, Chatron, Nicolas, Arzimanoglou, Alexis A., Labalme, Audrey, Cuddapah, Vishnu A., Ruggiero, Sarah M., Lecoquierre, Francois, Nicolas, Gael, Marie, Guerrot Anne, and Lebas, Axel
Published: 2024
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80. PD-0897 In vitro dosimetry for biological effectiveness assessment of targeted-alpha-therapy

Author: Doudard, A., primary, Corroyer-Dulmont, A., additional, Jaudet, C., additional, Bernaudin, M., additional, Valable, S., additional, Ledoux, X., additional, and Frelin-Labalme, A., additional
Published: 2023
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81. First observation of the cosmic ray shadow of the Moon and the Sun with KM3NeT/ORCA

Author: Aiello, S., primary, Albert, A., additional, Alves Garre, S., additional, Aly, Z., additional, Ambrosone, A., additional, Ameli, F., additional, Andre, M., additional, Anghinolfi, M., additional, Anguita, M., additional, Ardid, M., additional, Ardid, S., additional, Aublin, J., additional, Bagatelas, C., additional, Bailly-Salins, L., additional, Baret, B., additional, Pree, S. Basegmez du, additional, Becherini, Y., additional, Bendahman, M., additional, Benfenati, F., additional, Berbee, E., additional, Bertin, V., additional, Biagi, S., additional, Boettcher, M., additional, Cabo, M. Bou, additional, Boumaaza, J., additional, Bouta, M., additional, Bouwhuis, M., additional, Bozza, C., additional, Brânzaş, H., additional, Bruijn, R., additional, Brunner, J., additional, Bruno, R., additional, Buis, E., additional, Buompane, R., additional, Busto, J., additional, Caiffi, B., additional, Calvo, D., additional, Campion, S., additional, Capone, A., additional, Carenini, F., additional, Carretero, V., additional, Castaldi, P., additional, Celli, S., additional, Cerisy, L., additional, Chabab, M., additional, Chau, N., additional, Chen, A., additional, Moursli, R. Cherkaoui El, additional, Cherubini, S., additional, Chiarella, V., additional, Chiarusi, T., additional, Circella, M., additional, Cocimano, R., additional, Coelho, J. A. B., additional, Coleiro, A., additional, Coniglione, R., additional, Coyle, P., additional, Creusot, A., additional, Cruz, A., additional, Cuttone, G., additional, Dallier, R., additional, Darras, Y., additional, De Benedittis, A., additional, De Martino, B., additional, Burgo, R. Del, additional, Palma, I. Di, additional, Dìaz, A. F., additional, Diego-Tortosa, D., additional, Distefano, C., additional, Domi, A., additional, Donzaud, C., additional, Dornic, D., additional, Dörr, M., additional, Drakopoulou, E., additional, Drouhin, D., additional, Eberl, T., additional, Eddyamoui, A., additional, Eeden, T. van, additional, Eff, M., additional, Eijk, D. van, additional, Bojaddaini, I. El, additional, Hedri, S. El, additional, Enzenhöfer, A., additional, Espinosa, V., additional, Ferrara, G., additional, Filipović, M. D., additional, Filippini, F., additional, Fusco, L. A., additional, Gabriel, J., additional, Gal, T., additional, Méndez, J. García, additional, Soto, A. Garcia, additional, Garufi, F., additional, Oliver, C. Gatius, additional, Geißelbrecht, N., additional, Gialanella, L., additional, Giorgio, E., additional, Girardi, A., additional, Goos, I., additional, Gozzini, S. R., additional, Gracia, R., additional, Graf, K., additional, Guderian, D., additional, Guidi, C., additional, Guillon, B., additional, Gutiérrez, M., additional, Haegel, L., additional, Haren, H. van, additional, Heijboer, A., additional, Hekalo, A., additional, Hennig, L., additional, Hernández-Rey, J. J., additional, Huang, F., additional, Ibnsalih, W. Idrissi, additional, Illuminati, G., additional, James, C. W., additional, Janezashvili, D., additional, de Jong, M., additional, de Jong, P., additional, Jung, B. J., additional, Kalaczyński, P., additional, Kalekin, O., additional, Katz, U. F., additional, Chowdhury, N. R. Khan, additional, Kistauri, G., additional, Knaap, F. van der, additional, Kooijman, P., additional, Kouchner, A., additional, Kulikovskiy, V., additional, Labalme, M., additional, Lahmann, R., additional, Lakhal, A., additional, Lamoureux, M., additional, Larosa, G., additional, Lastoria, C., additional, Lazo, A., additional, Breton, R. Le, additional, Stum, S. Le, additional, Lehaut, G., additional, Leonora, E., additional, Lessing, N., additional, Levi, G., additional, Liang, S., additional, Clark, M. Lindsey, additional, Longhitano, F., additional, Maderer, L., additional, Majumdar, J., additional, Mańczak, J., additional, Margiotta, A., additional, Marinelli, A., additional, Markou, C., additional, Martin, L., additional, Martínez-Mora, J. A., additional, Martini, A., additional, Marzaioli, F., additional, Mastrodicasa, M., additional, Mastroianni, S., additional, Melis, K. W., additional, Miccichè, S., additional, Miele, G., additional, Migliozzi, P., additional, Migneco, E., additional, Mijakowski, P., additional, Mollo, C. M., additional, Morales-Gallegos, L., additional, Morley-Wong, C., additional, Moussa, A., additional, Muller, R., additional, Musone, M. R., additional, Musumeci, M., additional, Nauta, L., additional, Navas, S., additional, Nicolau, C. A., additional, Nkosi, B., additional, Fearraigh, B. Ó., additional, Orlando, A., additional, Oukacha, E., additional, González, J. Palacios, additional, Papalashvili, G., additional, Papaleo, R., additional, Pastor Gomez, E. J., additional, Păun, A. M., additional, Păvălaş, G. E., additional, Pellegrino, C., additional, Peña Martínez, S., additional, Perrin-Terrin, M., additional, Perronnel, J., additional, Pestel, V., additional, Piattelli, P., additional, Pisanti, O., additional, Poirè, C., additional, Popa, V., additional, Pradier, T., additional, Pulvirenti, S., additional, Quéméner, G., additional, Rahaman, U., additional, Randazzo, N., additional, Razzaque, S., additional, Rea, I. C., additional, Real, D., additional, Reck, S., additional, Riccobene, G., additional, Robinson, J., additional, Romanov, A., additional, Greus, F. Salesa, additional, Samtleben, D. F. E., additional, Losa, A. Sánchez, additional, Sanguineti, M., additional, Santonastaso, C., additional, Santonocito, D., additional, Sapienza, P., additional, Sathe, A., additional, Schnabel, J., additional, Schneider, M. F., additional, Schumann, J., additional, Schutte, H. M., additional, Seneca, J., additional, Sgura, I., additional, Shanidze, R., additional, Sharma, A., additional, Simonelli, A., additional, Sinopoulou, A., additional, Smirnov, M. V., additional, Spisso, B., additional, Spurio, M., additional, Stavropoulos, D., additional, Stellacci, S. M., additional, Taiuti, M., additional, Tavzarashvili, K., additional, Tayalati, Y., additional, Tedjditi, H., additional, Thiersen, H., additional, Tsagkli, S., additional, Tsourapis, V., additional, Tzamariudaki, E., additional, Elewyck, V. Van, additional, Vannoye, G., additional, Vasileiadis, G., additional, Versari, F., additional, Viola, S., additional, Vivolo, D., additional, Warnhofer, H., additional, Wilms, J., additional, de Wolf, E., additional, Yepes-Ramirez, H., additional, Yousfi, T., additional, Zavatarelli, S., additional, Zegarelli, A., additional, Zito, D., additional, Zornoza, J. D., additional, Zúñiga, J., additional, and Zywucka, N., additional
Published: 2023
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82. Comparison of two next-generation sequencing kits for diagnosis of epileptic disorders with a user-friendly tool for displaying gene coverage, DeCovA

Author: Dimassi, Sarra, Simonet, Thomas, Labalme, Audrey, Boutry-Kryza, Nadia, Campan-Fournier, Amandine, Lamy, Raphaelle, Bardel, Claire, Elsensohn, Mad-Hélénie, Roucher-Boulez, Florence, Chatron, Nicolas, Putoux, Audrey, de Bellescize, Julitta, Ville, Dorothée, Schaeffer, Laurent, Roy, Pascal, Mougou-Zerelli, Soumaya, Saad, Ali, Calender, Alain, Sanlaville, Damien, and Lesca, Gaetan
Published: 2015
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83. Deconvolution methods used for the development of a neutron spectrometer

Author: Simonetti Claude-Alexandre, Labalme Marc, Trolet Jean-Lionel, and Mary Patrick
Subjects: environmental and medical sciences, unfolding methods, monte-carlo simulations, Physics, QC1-999
Abstract: To fulfill the requirements of the industry, the feasibility of a transportable neutron spectrometer is under study by our collaboration. Preliminary studies have led to a solution based on a unique-multi-detectors-Bonner sphere, which has the advantage to simultaneously perform many neutrons-measurements through thermal neutron detectors placed at different depths inside a polyethylene sphere. The incident neutron energy is then reconstructed using unfolding methods. The optimization of the layout of the detectors in the sphere and of the diameter of the sphere was performed thanks to GEANT4 simulations, coupled to unfolding methods such as least-squares, maximum of entropy or maximum of likelihood. Different unfolding methods have been tested. For the time being, the best unfolding results were obtained by the computer codes M.A.X.E.D. and G.R.A.V.E.L., formalized by the Nuclear Energy Agency (N.E.A.). A “personal” method based on the maximum of entropy coupled to the maximum of likelihood gives good results as well, but a few convergence parameters have still to be optimized. In the present paper, a solution of a multi-detectors-Bonner sphere is presented as well as results of unfolded neutron energy spectra. The results obtained show a good agreement with unmoderated and moderated Am/Be and 252Cf spectra.
Published: 2021
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84. Molecular characterization of a cohort of 73 patients with infantile spasms syndrome

Author: Boutry-Kryza, Nadia, Labalme, Audrey, Ville, Dorothee, de Bellescize, Julitta, Touraine, Renaud, Prieur, Fabienne, Dimassi, Sarra, Poulat, Anne-Lise, Till, Marianne, Rossi, Massimiliano, Bourel-Ponchel, Emilie, Delignières, Aline, Le Moing, Anne-Gaelle, Rivier, Clotilde, des Portes, Vincent, Edery, Patrick, Calender, Alain, Sanlaville, Damien, and Lesca, Gaetan
Published: 2015
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85. Targeted next‐generation sequencing in a large series of fetuses with severe renal diseases

Author: Penelope Jordan, Guillaume Dorval, Christelle Arrondel, Vincent Morinière, Carole Tournant, Marie‐Pierre Audrezet, Laurence Michel‐Calemard, Audrey Putoux, Gaethan Lesca, Audrey Labalme, Sandra Whalen, Laurence Loeuillet, Jelena Martinovic, Tania Attie‐Bitach, Bettina Bessières, Elise Schaefer, Sophie Scheidecker, Laetitia Lambert, Claire Beneteau, Olivier Patat, Odile Boute‐Benejean, Arnaud Molin, Fabien Guimiot, Nicolas Fontanarosa, Mathilde Nizon, Mathilde Lefebvre, Cécile Jeanpierre, Sophie Saunier, and Laurence Heidet
Subjects: Male, Homozygote, High-Throughput Nucleotide Sequencing, Cell Cycle Proteins, Kidney, Polycystic Kidney, Autosomal Dominant, Cytoskeletal Proteins, Fetus, Antigens, Neoplasm, Mutation, Genetics, Humans, Female, Kidney Diseases, Genetics (clinical)
Abstract: We report the screening of a large panel of genes in a series of 100 fetuses (98 families) affected with severe renal defects. Causative variants were identified in 22% of cases, greatly improving genetic counseling. The percentage of variants explaining the phenotype was different according to the type of phenotype. The highest diagnostic yield was found in cases affected with the ciliopathy-like phenotype (11/15 families and, in addition, a single heterozygous or a homozygous Class 3 variant in PKHD1 in three unrelated cases with autosomal recessive polycystic kidney disease). The lowest diagnostic yield was observed in cases with congenital anomalies of the kidney and urinary tract (9/78 families and, in addition, Class 3 variants in GREB1L in three unrelated cases with bilateral renal agenesis). Inheritance was autosomal recessive in nine genes (PKHD1, NPHP3, CEP290, TMEM67, DNAJB11, FRAS1, ACE, AGT, and AGTR1), and autosomal dominant in six genes (PKD1, PKD2, PAX2, EYA1, BICC1, and MYOCD). Finally, we developed an original approach of next-generation sequencing targeted RNA sequencing using the custom capture panel used for the sequencing of DNA, to validate one MYOCD heterozygous splicing variant identified in two male siblings with megabladder and inherited from their healthy mother.
Published: 2022
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86. Application of a new spectral deconvolution method for in vitro dosimetry in assessment of targeted alpha therapy

Author: Doudard, Alexis, Corroyer‐dulmont, Aurélien, Jaudet, Cyril, Bernaudin, Myriam, Valable, Samuel, Ledoux, Xavier, Frelin‐labalme, Anne‐marie, Grand Accélérateur National d'Ions Lourds (GANIL), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [PHYS]Physics [physics], General Medicine
Abstract: International audience; BackgroundThe improvement of in vitro assessment of targeted alpha therapy (reproducibility, comparability of experiments horizontal ellipsis ) requires precise evaluation of the dose delivered to the cells. To answer this need, a previous study proposed an innovative dosimetry method based on alpha-spectroscopy and a specific deconvolution process to recover the spatial distribution of Pb-212 isotopes inside in vitro culture wells. Nevertheless, although promising, the deconvolution method was time consuming and only tested for a simple isotope decay chain. PurposeThe purpose of this work is to propose a new matrix deconvolution method of alpha spectra based on a constrained-non-negative-maximum-likelihood decomposition, both faster and offering a greater modelling flexibility, allowing to study independently the kinetics of each of the daughter nuclides of complex decay chains (illustrated here with Ra-223) in in vitro culture wells. MethodsFirstly, the performance of the new method was fully evaluated through Monte Carlo simulations of in vitro irradiations. Different spatial distributions of Pb-212 and Ra-223, the corresponding alpha spectra measured by a silicon detector and the doses delivered to the cells were simulated with Geant4. The deconvolution results were then compared to the simulation results. Secondly, measurements were carried out in culture wells without cells containing 15 kBq of Pb-212 or 9.3 kBq of Ra-223, placed above silicon detectors recording alpha spectra in real time. The matrix deconvolution was then applied to determine the spatial and temporal distribution of all alpha-emitting daughters of studied isotopes. ResultsThe matrix deconvolution was proved to recover the simulated distribution gradients, ensuring simulated doses within 3 % for both tested radionuclides, with errors on dose normally distributed around the reference value (consequently not exhibiting any bias), even in the case of complex decay chains as Ra-223. The experimental study of Pb-212 and Ra-223 showed highly inhomogeneous distributions and time evolution of the concentration gradients, consistent with the previous study. Furthermore, it highlighted the complex kinetics of Ra-223 with different distributions of its alpha-emitting daughters (Rn-219, Po-215, At-215, Bi-211, Po-211). ConclusionsThis study validates a new deconvolution method, fast and flexible, that proved to be accurate and reliable. This method allowed to reveal the complexity of isotopes kinetics in in vitro experiments, especially with complex decay chains. Experimental dosimetry, necessary to improve reliability of in vitro studies in targeted alpha therapy, is demonstrated to be feasible with the proposed method.
Published: 2023
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87. Enhanced Energy Transfer in A π‐Conjugated Covalent Organic Framework Facilitates Excited‐State Nickel Catalysis

Author: Yingjie Fan, Dong Won Kang, Steven Labalme, Jinhong Li, and Wenbin Lin
Subjects: General Medicine, General Chemistry, Catalysis
Published: 2023
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88. Functional Assessment of a New PBX1 Variant in a 46,XY Fetus with Severe Syndromic Difference of Sexual Development through CRISPR-Cas9 Gene Editing

Author: Laura Mary, Delphine Leclerc, Audrey Labalme, Pascale Bellaud, Séverine Mazaud-Guittot, Stéphane Dréano, Bertrand Evrard, Antoine Bigand, Aurélie Cauchoix, Philippe Loget, Anna Lokchine, Laurence Cluzeau, David Gilot, Marc-Antoine Belaud-Rotureau, Sylvie Jaillard, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CHU Pontchaillou [Rennes], Oncogenesis, Stress, Signaling (OSS), Université de Rennes (UR)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CRLCC Eugène Marquis (CRLCC), Hospices Civils de Lyon (HCL), Biosit : biologie, santé, innovation technologique (SFR UMS CNRS 3480 - INSERM 018), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), H2P2 - Histo Pathologie Hight Precision (H2P2), Université de Rennes (UR)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), This study received financial support from AVIESAN Plan Cancer, Région Bretagne, Agence Nationale de Recherche, University of Rennes 1 and Ministère de la Recherche et de l’Enseignement Supérieur (MESRI, PhD Scholarship)., and Jonchère, Laurent
Subjects: [SDV.GEN]Life Sciences [q-bio]/Genetics, sexual development, Genetics, DSD, genome editing, [SDV.GEN] Life Sciences [q-bio]/Genetics, RNA-seq, CRISPR-Cas9, Genetics (clinical)
Abstract: International audience; Sexual development is a complex process relying on numerous genes. Disruptions in some of these genes are known to cause differences of sexual development (DSDs). Advances in genome sequencing allowed the discovery of new genes implicated in sexual development, such as PBX1. We present here a fetus with a new PBX1 NM_002585.3: c.320G>A,p.(Arg107Gln) variant, presenting with severe DSD along with renal and lung malformations. Using CRISPR-Cas9 gene editing on HEK293T cells, we generated a KD cell line for PBX1. The KD cell line showed reduced proliferation and adhesion properties compared with HEK293T cells. HEK293T and KD cells were then transfected plasmids coding either PBX1 WT or PBX1-320G>A (mutant). WT or mutant PBX1 overexpression rescued cell proliferation in both cell lines. RNA-seq analyses showed less than 30 differentially expressed genes, in ectopic mutant-PBX1-expressing cells compared with WT-PBX1. Among them, U2AF1, encoding a splicing factor subunit, is an interesting candidate. Overall, mutant PBX1 seems to have modest effects compared with WT PBX1 in our model. However, the recurrence of PBX1 Arg107 substitution in patients with closely related phenotypes calls for its impact in human diseases. Further functional studies are needed to explore its effects on cellular metabolism.
Published: 2023
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89. Molecular Engineering of Metal–Organic Layers for Sustainable Tandem and Synergistic Photocatalysis

Author: Fan, Yingjie, primary, Zheng, Haifeng, additional, Labalme, Steven, additional, and Lin, Wenbin, additional
Published: 2023
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90. Enhanced Energy Transfer in A π‐Conjugated Covalent Organic Framework Facilitates Excited‐State Nickel Catalysis

Author: Fan, Yingjie, primary, Kang, Dong Won, additional, Labalme, Steven, additional, Li, Jinhong, additional, and Lin, Wenbin, additional
Published: 2023
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91. KM3NeT broadcast optical data transport system

Author: Aiello, S., primary, Albert, A., additional, Alves Garre, S., additional, Aly, Z., additional, Ambrosone, A., additional, Ameli, F., additional, Andre, M., additional, Anghinolfi, M., additional, Anguita, M., additional, Ardid, M., additional, Ardid, S., additional, Aublin, J., additional, Bagatelas, C., additional, Bailly-Salins, L., additional, Baret, B., additional, Basegmez du Pree, S., additional, Becherini, Y., additional, Bendahman, M., additional, Benfenati, F., additional, Berbee, E., additional, Bertin, V., additional, Biagi, S., additional, Boettcher, M., additional, Bou Cabo, M., additional, Boumaaza, J., additional, Bouta, M., additional, Bouwhuis, M., additional, Bozza, C., additional, Brânzaş, H., additional, Bruijn, R., additional, Brunner, J., additional, Bruno, R., additional, Buis, E., additional, Buompane, R., additional, Busto, J., additional, Caiffi, B., additional, Calvo, D., additional, Campion, S., additional, Capone, A., additional, Carenini, F., additional, Carretero, V., additional, Castaldi, P., additional, Celli, S., additional, Cerisy, L., additional, Chabab, M., additional, Chau, N., additional, Chen, A., additional, Cherkaoui El Moursli, R., additional, Cherubini, S., additional, Chiarella, V., additional, Chiarusi, T., additional, Circella, M., additional, Cocimano, R., additional, Coelho, J.A.B., additional, Coleiro, A., additional, Coniglione, R., additional, Coyle, P., additional, Creusot, A., additional, Cruz, A., additional, Cuttone, G., additional, D'Amico, A., additional, Dallier, R., additional, Darras, Y., additional, De Benedittis, A., additional, De Martino, B., additional, Del Burgo, R., additional, Di Palma, I., additional, Díaz, A.F., additional, Diego-Tortosa, D., additional, Distefano, C., additional, Domi, A., additional, Donzaud, C., additional, Dornic, D., additional, Dörr, M., additional, Drakopoulou, E., additional, Drouhin, D., additional, Eberl, T., additional, Eddyamoui, A., additional, van Eeden, T., additional, Eff, M., additional, van Eijk, D., additional, El Bojaddaini, I., additional, El Hedri, S., additional, Enzenhöfer, A., additional, Espinosa, V., additional, Ferrara, G., additional, Filipović, M.D., additional, Filippini, F., additional, Fusco, L.A., additional, Gabriel, J., additional, Gal, T., additional, García Méndez, J., additional, Garcia Soto, A., additional, Garufi, F., additional, Gatius Oliver, C., additional, Geißelbrecht, N., additional, Gialanella, L., additional, Giorgio, E., additional, Girardi, A., additional, Goos, I., additional, Gozzini, S.R., additional, Gracia, R., additional, Graf, K., additional, Guderian, D., additional, Guidi, C., additional, Guillon, B., additional, Gutiérrez, M., additional, Haegel, L., additional, van Haren, H., additional, Heijboer, A., additional, Hekalo, A., additional, Hennig, L., additional, Hernández-Rey, J.J., additional, Huang, F., additional, Idrissi Ibnsalih, W., additional, Illuminati, G., additional, James, C.W., additional, Janezashvili, D., additional, de Jong, M., additional, de Jong, P., additional, Jung, B.J., additional, Kalaczyński, P., additional, Kalekin, O., additional, Katz, U.F., additional, Khan Chowdhury, N.R., additional, Kistauri, G., additional, van der Knaap, F., additional, Kooijman, P., additional, Kouchner, A., additional, Kulikovskiy, V., additional, Labalme, M., additional, Lahmann, R., additional, Lakhal, A., additional, Lamoureux, M., additional, Larosa, G., additional, Lastoria, C., additional, Lazo, A., additional, Le Breton, R., additional, Le Stum, S., additional, Lehaut, G., additional, Leonora, E., additional, Lessing, N., additional, Levi, G., additional, Liang, S., additional, Lindsey Clark, M., additional, Longhitano, F., additional, Maderer, L., additional, Majumdar, J., additional, Mańczak, J., additional, Margiotta, A., additional, Marinelli, A., additional, Markou, C., additional, Martin, L., additional, Martínez-Mora, J.A., additional, Martini, A., additional, Marzaioli, F., additional, Mastrodicasa, M., additional, Mastroianni, S., additional, Melis, K.W., additional, Miccichè, S., additional, Miele, G., additional, Migliozzi, P., additional, Migneco, E., additional, Mijakowski, P., additional, Mollo, C.M., additional, Morales-Gallegos, L., additional, Morley-Wong, C., additional, Moussa, A., additional, Muller, R., additional, Musone, M.R., additional, Musumeci, M., additional, Nauta, L., additional, Navas, S., additional, Nicolau, C.A., additional, Nkosi, B., additional, Ó Fearraigh, B., additional, Orlando, A., additional, Oukacha, E., additional, Palacios González, J., additional, Papalashvili, G., additional, Papaleo, R., additional, Pastor Gomez, E.J., additional, Păun, A.M., additional, Păvălaş, G.E., additional, Pellegrino, C., additional, Peña Martínez, S., additional, Perrin-Terrin, M., additional, Perronnel, J., additional, Pestel, V., additional, Piattelli, P., additional, Pisanti, O., additional, Poirè, C., additional, Popa, V., additional, Pradier, T., additional, Pulvirenti, S., additional, Quéméner, G., additional, Rahaman, U., additional, Randazzo, N., additional, Razzaque, S., additional, Rea, I.C., additional, Real, D., additional, Reck, S., additional, Riccobene, G., additional, Robinson, J., additional, Romanov, A., additional, Salesa Greus, F., additional, Samtleben, D.F.E., additional, Sánchez Losa, A., additional, Sanguineti, M., additional, Santonastaso, C., additional, Santonocito, D., additional, Sapienza, P., additional, Sathe, A., additional, Schmelling, J., additional, Schnabel, J., additional, Schneider, M.F., additional, Schumann, J., additional, M. Schutte, H., additional, Seneca, J., additional, Sgura, I., additional, Shanidze, R., additional, Sharma, A., additional, Simonelli, A., additional, Sinopoulou, A., additional, Smirnov, M.V., additional, Spisso, B., additional, Spurio, M., additional, Stavropoulos, D., additional, Stellacci, S.M., additional, Taiuti, M., additional, Tavzarashvili, K., additional, Tayalati, Y., additional, Tedjditi, H., additional, Thiersen, H., additional, Tsagkli, S., additional, Tsourapis, V., additional, Tzamariudaki, E., additional, Van Elewyck, V., additional, Vannoye, G., additional, Vasileiadis, G., additional, Versari, F., additional, Viola, S., additional, Vivolo, D., additional, Warnhofer, H., additional, Wilms, J., additional, de Wolf, E., additional, Yepes-Ramirez, H., additional, Yousfi, T., additional, Zavatarelli, S., additional, Zegarelli, A., additional, Zito, D., additional, Zornoza, J.D., additional, Zúñiga, J., additional, and Zywucka, N., additional
Published: 2023
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92. Functional Assessment of a New PBX1 Variant in a 46,XY Fetus with Severe Syndromic Difference of Sexual Development through CRISPR-Cas9 Gene Editing

Author: Mary, Laura, primary, Leclerc, Delphine, additional, Labalme, Audrey, additional, Bellaud, Pascale, additional, Mazaud-Guittot, Séverine, additional, Dréano, Stéphane, additional, Evrard, Bertrand, additional, Bigand, Antoine, additional, Cauchoix, Aurélie, additional, Loget, Philippe, additional, Lokchine, Anna, additional, Cluzeau, Laurence, additional, Gilot, David, additional, Belaud-Rotureau, Marc-Antoine, additional, and Jaillard, Sylvie, additional
Published: 2023
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93. Performance of the reconstruction algorithms of the FIRST experiment pixel sensors vertex detector

Author: Rescigno, R., Finck, Ch., Juliani, D., Spiriti, E., Baudot, J., Abou-Haidar, Z., Agodi, C., Alvarez, M.A.G., Aumann, T., Battistoni, G., Bocci, A., Böhlen, T.T., Boudard, A., Brunetti, A., Carpinelli, M., Cirrone, G.A.P., Cortes-Giraldo, M.A., Cuttone, G., De Napoli, M., Durante, M., Gallardo, M.I., Golosio, B., Iarocci, E., Iazzi, F., Ickert, G., Introzzi, R., Krimmer, J., Kurz, N., Labalme, M., Leifels, Y., Le Fevre, A., Leray, S., Marchetto, F., Monaco, V., Morone, M.C., Oliva, P., Paoloni, A., Patera, V., Piersanti, L., Pleskac, R., Quesada, J.M., Randazzo, N., Romano, F., Rossi, D., Rousseau, M., Sacchi, R., Sala, P., Sarti, A., Scheidenberger, C., Schuy, C., Sciubba, A., Sfienti, C., Simon, H., Sipala, V., Tropea, S., Vanstalle, M., and Younis, H.
Published: 2014
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94. Phenotypic spectrum and transcriptomic profile associated with germline variants in TRAF7

Author: Robert A. Hegele, Maria Iascone, Kevin A. Shapiro, Nicolas Chatron, Marwan Shinawi, Joel Charrow, Jeffrey W. Innis, Luitgard Graul-Neumann, Joanna Goes Castro Meira, Anna Lehman, Dawn L. Earl, Victoria R. Sanders, Shannon Rego, David A. Sweetser, Clémantine Dimartino, Wilhelmina S. Kerstjens-Frederikse, Antonio Vitobello, Davor Lessel, Daniel Grinberg, Laurence Faivre, Ryan Peretz, Katherine M. Christensen, Emma Reesor, Erin Beaver, Elizabeth Wohler, Margot R.F. Reijnders, Deborah Barbouth, Anna Cereda, Kaja Kristine Selmer, Melissa A. Walker, Barbro Stadheim, Alessandro Serretti, Helen Kingston, Jill Clayton-Smith, Raymond Lewandowski, Bernarda Lozić, Robert Stratton, Amelia Kirby, Anne H. O’Donnell-Luria, Sara Gabbiadini, Susanna Balcells, Myriam Oufadem, Christel Thauvin, Maha Aly, Wendy K. Chung, Susan M. White, Lauren C. Briere, Thomas Smol, Stanislas Lyonnet, Roberto Colombo, Catherine E. Keegan, Marie T. McDonald, Melanie Parisot, Tiong Yang Tan, Brian Wong, Christopher T. Gordon, Magnus Dehli Vigeland, Frances A. High, Emily Bryant, Audrey Labalme, Nara Sobreira, Arnold Munnich, Jeanne Amiel, Dayna Morel Swols, Raquel Rabionet, Laura Castilla-Vallmanya, Jennifer Heeley, Gunnar Houge, Michael J. Gambello, Bernardo Blanco-Sánchez, Lynn Pais, Olena M. Vaske, Roser Urreizti, Alison Wray, Veronique Pingault, Damien Sanlaville, John Christodoulou, John Millichap, Valérie Cormier-Daire, Parul Jayakar, Helen Cox, Frédéric Tran Mau-Them, Belinda Chong, Victoria Mok Siu, Anne Slavotinek, Antonie J. van Essen, Ingvild Aukrust, Lorne A. Clarke, Rachel Gannaway, Anne Dieux-Coeslier, Patrick Nitschké, Tony Yao, Simon Sadedin, Danielle Karlowicz, Christelle Rougeot, Christine Bole-Feysot, Sandra Yang, Megan T. Cho, Gaetan Lesca, Christiane Zweier, Castilla-Vallmanya L., Selmer K.K., Dimartino C., Rabionet R., Blanco-Sanchez B., Yang S., Reijnders M.R.F., van Essen A.J., Oufadem M., Vigeland M.D., Stadheim B., Houge G., Cox H., Kingston H., Clayton-Smith J., Innis J.W., Iascone M., Cereda A., Gabbiadini S., Chung W.K., Sanders V., Charrow J., Bryant E., Millichap J., Vitobello A., Thauvin C., Mau-Them F.T., Faivre L., Lesca G., Labalme A., Rougeot C., Chatron N., Sanlaville D., Christensen K.M., Kirby A., Lewandowski R., Gannaway R., Aly M., Lehman A., Clarke L., Graul-Neumann L., Zweier C., Lessel D., Lozic B., Aukrust I., Peretz R., Stratton R., Smol T., Dieux-Coeslier A., Meira J., Wohler E., Sobreira N., Beaver E.M., Heeley J., Briere L.C., High F.A., Sweetser D.A., Walker M.A., Keegan C.E., Jayakar P., Shinawi M., Kerstjens-Frederikse W.S., Earl D.L., Siu V.M., Reesor E., Yao T., Hegele R.A., Vaske O.M., Rego S., Shapiro K.A., Wong B., Gambello M.J., McDonald M., Karlowicz D., Colombo R., Serretti A., Pais L., O'Donnell-Luria A., Wray A., Sadedin S., Chong B., Tan T.Y., Christodoulou J., White S.M., Slavotinek A., Barbouth D., Morel Swols D., Parisot M., Bole-Feysot C., Nitschke P., Pingault V., Munnich A., Cho M.T., Cormier-Daire V., Balcells S., Lyonnet S., Grinberg D., Amiel J., Urreizti R., Gordon C.T., MUMC+: DA KG Polikliniek (9), and RS: FHML non-thematic output
Subjects: 0301 basic medicine, NF-KAPPA-B, PROTEIN, 030105 genetics & heredity, medicine.disease_cause, Germline, Transcriptome, ACTIVATION, POLYUBIQUITINATION, Missense mutation, Exome, Genetics (clinical), Genetics, Sanger sequencing, Mutation, leads, Necrosi, craniofacial development, Phenotype, Tumor Necrosis Factor Receptor-Associated Peptides and Proteins, intellectual disability, patent ductus arteriosu, symbols, Mutation, Missense, Biology, traf7, Article, akt1, target, 03 medical and health sciences, symbols.namesake, Necrosis, patent ductus arteriosus, medicine, Humans, blepharophimosi, Tumors, MUTATIONS, Fibroblasts, medicine.disease, Blepharophimosis, TRAF7, blepharophimosis, GENOMIC ANALYSIS, Germ Cells, 030104 developmental biology, MENINGIOMAS
Abstract: PURPOSE: Somatic variants in tumor necrosis factor receptor-associated factor 7 (TRAF7) cause meningioma, while germline variants have recently been identified in seven patients with developmental delay and cardiac, facial, and digital anomalies. We aimed to define the clinical and mutational spectrum associated with TRAF7 germline variants in a large series of patients, and to determine the molecular effects of the variants through transcriptomic analysis of patient fibroblasts.METHODS: We performed exome, targeted capture, and Sanger sequencing of patients with undiagnosed developmental disorders, in multiple independent diagnostic or research centers. Phenotypic and mutational comparisons were facilitated through data exchange platforms. Whole-transcriptome sequencing was performed on RNA from patient- and control-derived fibroblasts.RESULTS: We identified heterozygous missense variants in TRAF7 as the cause of a developmental delay-malformation syndrome in 45 patients. Major features include a recognizable facial gestalt (characterized in particular by blepharophimosis), short neck, pectus carinatum, digital deviations, and patent ductus arteriosus. Almost all variants occur in the WD40 repeats and most are recurrent. Several differentially expressed genes were identified in patient fibroblasts.CONCLUSION: We provide the first large-scale analysis of the clinical and mutational spectrum associated with the TRAF7 developmental syndrome, and we shed light on its molecular etiology through transcriptome studies.
Published: 2020

95. The LPCTrap experiment: measurement of the β-ν angular correlation in 6He using a transparent Paul trap

Author: Liénard, E., Ban, G., Blieck, J., Durand, D., Duval, F., Fléchard, X., Herbane, M., Labalme, M., Lemière, Y., Mauger, F., Méry, A., Naviliat-Cuncic, O., Rodriguez, D., Thomas, J. C., Dilling, J., editor, Comyn, M., editor, Thompson, J., editor, and Gwinner, G., editor
Published: 2007
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96. In vitro dosimetry for assessment of Targeted-Alpha-Therapy

Author: Doudard, A., Corroyer-Dulmont, A, Jaudet, C, Bernaudin, M, Valable, S, Frelin-Labalme, A.M., Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Imagerie et Stratégies Thérapeutiques pour les Cancers et Tissus cérébraux (ISTCT), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS), Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), and Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)
Subjects: [SDV]Life Sciences [q-bio]
Abstract: CERVOXY; National audience
Published: 2022

97. First observation of the cosmic ray shadow of the Moon and the Sun with KM3NeT/ORCA

Author: Aiello, S, Albert, A, Alves Garre, S, Aly, Z, Ambrosone, A, Ameli, F, Andre, M, Anghinolfi, M, Anguita, M, Ardid, M, Ardid, S, Aublin, J, Bagatelas, C, Bailly-Salins, L, Baret, B, Basegmez Du Pree, S, Becherini, Y, Bendahman, M, Benfenati, F, Berbee, E, Bertin, V, Biagi, S, Boettcher, M, Cabo, M. Bou, Boumaaza, J, Bouta, M, Bouwhuis, M, Bozza, C, Brânzas, H, Bruijn, R, Brunner, J, Bruno, R, Buis, E, Buompane, R, Busto, J, Caiffi, B, Calvo, D, Campion, S, Capone, A, Carenini, F, Carretero, V, Castaldi, P, Celli, S, Cerisy, L, Chabab, M, Chau, N, Chen, A, Cherkaoui El Moursli, R, Cherubini, S, Chiarella, V, Chiarusi, T, Circella, M, Cocimano, R, Coelho, J.A.B, Coleiro, A, Coniglione, R, Coyle, P, Creusot, A, Cruz, A, Cuttone, G, Dallier, R, Darras, Y, de Benedittis, A, de Martino, B, del Burgo, R, Di Palma, I, Dìaz, A.F, Diego-Tortosa, D, Distefano, C, Domi, A, Donzaud, C, Dornic, D, Dörr, M, Drakopoulou, E, Drouhin, D, Eberl, T, Eddyamoui, A, van Eeden, T, Eff, M, van Eijk, D, El Bojaddaini, I, El Hedri, S, Enzenhöfer, A, Espinosa, V, Ferrara, G, Filipovíc, M.D, Filippini, F, Fusco, L.A, Gabriel, J, Gal, T, García Méndez, J, Garcia Soto, A, Garufi, F, Gatius Oliver, C, Geißelbrecht, N, Gialanella, L, Giorgio, E, Girardi, A, Goos, I, Gozzini, S.R, Gracia, R, Graf, K, Guderian, D, Guidi, C, Guillon, B, Gutiérrez, M, Haegel, L, van Haren, H, Heijboer, A, Hekalo, A, Hennig, L, Hernández-Rey, J.J, Huang, F, Ibnsalih, W. Idrissi, Illuminati, G, James, C.W, Janezashvili, D, de Jong, M, de Jong, P, Jung, B.J, Kalaczynski, P, Kalekin, O, Katz, U.F, Khan Chowdhury, N.R, Kistauri, G, van der Knaap, F, Kooijman, P, Kouchner, A, Kulikovskiy, V, Labalme, M, Lahmann, R, Lakhal, A, Lamoureux, M, Larosa, G, Lastoria, C, Lazo, A, Le Breton, R, Le Stum, S, Lehaut, G, Leonora, E, Lessing, N, Levi, G, Liang, S, Lindsey Clark, M, Longhitano, F, Maderer, L, Majumdar, J, Manczak, J, Margiotta, A, Marinelli, A, Markou, C, Martin, L, Martínez-Mora, J.A, Martini, A, Marzaioli, F, Mastrodicasa, M, Mastroianni, S, Melis, K.W, Miccichè, S, Miele, G, Migliozzi, P, Migneco, E, Mijakowski, P, Mollo, C.M, Morales-Gallegos, L, Morley-Wong, C, Moussa, A, Muller, R, Musone, M.R, Musumeci, M, Nauta, L, Navas, S, Nicolau, C.A, Nkosi, B, Ó Fearraigh, B, Orlando, A, Oukacha, E, Palacios González, J, Papalashvili, G, Papaleo, R, Gomez, E.J. Pastor, Paun, A.M, Pavalas, G.E, Pellegrino, C, Peña Martínez, S, Perrin-Terrin, M, Perronnel, J, Pestel, V, Piattelli, P, Pisanti, O, Poirè, C, Popa, V, Pradier, T, Pulvirenti, S, Quéméner, G, Rahaman, U, Randazzo, N, Razzaque, S, Rea, I.C, Real, D, Reck, S, Riccobene, G, Robinson, J, Romanov, A, Salesa Greus, F, Samtleben, D.F.E, Sánchez Losa, A, Sanguineti, M, Santonastaso, C, Santonocito, D, Sapienza, P, Sathe, A, Schnabel, J, Schneider, M.F, Schumann, J, Schutte, H.M, Seneca, J, Sgura, I, Shanidze, R, Sharma, A, Simonelli, A, Sinopoulou, A, Smirnov, M.V, Spisso, B, Spurio, M, Stavropoulos, D, Stellacci, S.M, Taiuti, M, Tavzarashvili, K, Tayalati, Y, Tedjditi, H, Thiersen, H, Tsagkli, S, Tsourapis, V, Tzamariudaki, E, van Elewyck, V, Vannoye, G, Vasileiadis, G, Versari, F, Viola, S, Vivolo, D, Warnhofer, H, Wilms, J, de Wolf, E, Yepes-Ramirez, H, Yousfi, T, Zavatarelli, S, Zegarelli, A, Zito, D, Zornoza, J.D, Zúñiga, J, Zywucka, N, Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Laboratoire Univers et Particules de Montpellier (LUPM), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), KM3NeT, Aiello, S., Albert, A., Alves Garre, S., Aly, Z., Ambrosone, A., Ameli, F., Andre, M., Anghinolfi, M., Anguita, M., Ardid, M., Ardid, S., Aublin, J., Bagatelas, C., Bailly-Salins, L., Baret, B., Pree, S. B., Becherini, Y., Bendahman, M., Benfenati, F., Berbee, E., Bertin, V., Biagi, S., Boettcher, M., Cabo, M. B., Boumaaza, J., Bouta, M., Bouwhuis, M., Bozza, C., Branzas, H., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Caiffi, B., Calvo, D., Campion, S., Capone, A., Carenini, F., Carretero, V., Castaldi, P., Celli, S., Cerisy, L., Chabab, M., Chau, N., Chen, A., Moursli, R. C. E., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Coniglione, R., Coyle, P., Creusot, A., Cruz, A., Cuttone, G., Dallier, R., Darras, Y., De Benedittis, A., De Martino, B., Burgo, R. D., Palma, I. D., Diaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Dorr, M., Drakopoulou, E., Drouhin, D., Eberl, T., Eddyamoui, A., Eeden, T., Eff, M., Eijk, D., Bojaddaini, I. E., Hedri, S. E., Enzenhofer, A., Espinosa, V., Ferrara, G., Filipovic, M. D., Filippini, F., Fusco, L. A., Gabriel, J., Gal, T., Mendez, J. G., Soto, A. G., Garufi, F., Oliver, C. G., Geisselbrecht, N., Gialanella, L., Giorgio, E., Girardi, A., Goos, I., Gozzini, S. R., Gracia, R., Graf, K., Guderian, D., Guidi, C., Guillon, B., Gutierrez, M., Haegel, L., Haren, H., Heijboer, A., Hekalo, A., Hennig, L., Hernandez-Rey, J. J., Huang, F., Ibnsalih, W. I., Illuminati, G., James, C. W., Janezashvili, D., de Jong, M., de Jong, P., Jung, B. J., Kalaczynski, P., Kalekin, O., Katz, U. F., Chowdhury, N. R. K., Kistauri, G., Knaap, F., Kooijman, P., Kouchner, A., Kulikovskiy, V., Labalme, M., Lahmann, R., Lakhal, A., Lamoureux, M., Larosa, G., Lastoria, C., Lazo, A., Breton, R. L., Stum, S. L., Lehaut, G., Leonora, E., Lessing, N., Levi, G., Liang, S., Clark, M. L., Longhitano, F., Maderer, L., Majumdar, J., Manczak, J., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Martinez-Mora, J. A., Martini, A., Marzaioli, F., Mastrodicasa, M., Mastroianni, S., Melis, K. W., Micciche, S., Miele, G., Migliozzi, P., Migneco, E., Mijakowski, P., Mollo, C. M., Morales-Gallegos, L., Morley-Wong, C., Moussa, A., Muller, R., Musone, M. R., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Nkosi, B., Fearraigh, B. O., Orlando, A., Oukacha, E., Gonzalez, J. P., Papalashvili, G., Papaleo, R., Pastor Gomez, E. J., Paun, A. M., Pavalas, G. E., Pellegrino, C., Pena Martinez, S., Perrin-Terrin, M., Perronnel, J., Pestel, V., Piattelli, P., Pisanti, O., Poire, C., Popa, V., Pradier, T., Pulvirenti, S., Quemener, G., Rahaman, U., Randazzo, N., Razzaque, S., Rea, I. C., Real, D., Reck, S., Riccobene, G., Robinson, J., Romanov, A., Greus, F. S., Samtleben, D. F. E., Losa, A. S., Sanguineti, M., Santonastaso, C., Santonocito, D., Sapienza, P., Sathe, A., Schnabel, J., Schneider, M. F., Schumann, J., Schutte, H. M., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Simonelli, A., Sinopoulou, A., Smirnov, M. V., Spisso, B., Spurio, M., Stavropoulos, D., Stellacci, S. M., Taiuti, M., Tavzarashvili, K., Tayalati, Y., Tedjditi, H., Thiersen, H., Tsagkli, S., Tsourapis, V., Tzamariudaki, E., Elewyck, V. V., Vannoye, G., Vasileiadis, G., Versari, F., Viola, S., Vivolo, D., Warnhofer, H., Wilms, J., de Wolf, E., Yepes-Ramirez, H., Yousfi, T., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zuniga, J., Zywucka, N., Centre Tecnològic de Vilanova i la Geltrú, and Universitat Politècnica de Catalunya. LAB - Laboratori d'Aplicacions Bioacústiques
Subjects: Astrofísica, Physics and Astronomy (miscellaneous), FOS: Physical sciences, Astrophysics, statistical analysis, muon, optical, detector: calibration, Neutrins, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Neutrinos, lunar, numerical calculations, Engineering (miscellaneous), KM3NeT, Monte Carlo, Instrumentation and Methods for Astrophysics (astro-ph.IM), Detectors òptics, High Energy Astrophysical Phenomena (astro-ph.HE), ANTARES, photomultiplier, background, Cherenkov radiation, Neutrino astrophysics, solar, flux, Cherenkov counter, angular resolution, cosmic radiation, shadowing, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], statistical, performance
Abstract: This article reports the first observation of the Moon and the Sun shadows in the sky distribution of cosmic-ray induced muons measured by the KM3NeT/ORCA detector. The analysed data-taking period spans from February 2020 to November 2021, when the detector had 6 Detection Units deployed at the bottom of the Mediterranean Sea, each composed of 18 Digital Optical Modules. The shadows induced by the Moon and the Sun were detected with a statistical significance of 4.2{\sigma} and 6.2{\sigma}, respectively, at their nominal position. This early result confirms the effectiveness of the detector calibration, in time, position and orientation and the accuracy of the event direction reconstruction. This also demonstrates the performance and the competitiveness of the detector in terms of pointing accuracy and angular resolution., Comment: 15 pages, 7 figures
Published: 2022
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98. Atmospheric neutrinos with the first KM3NeT/ORCA data and prospects for measuring the atmospheric neutrino flux

Author: Stavropoulos, D., Pestel, V., Aly, Z., Tzamariudaki, E., Markou, C., Ageron, M., Aiello, S., Albert, A., Alshamsi, M., Alves Garre, S., Ambrosone, A., Ameli, F., Andre, M., Androulakis, G., Anghinolfi, M., Anguita, M., Anton, G., Ardid, M., Ardid, S., Assal, W., Aublin, J., Bagatelas, C., Baret, B., Basegmez Du Pree, S., Bendahman, M., Benfenati, F., Berbee, E., Den Berg, A. M., Bertin, V., Beurthey, S., Beveren, V., Biagi, S., Billault, M., Bissinger, M., Boettcher, M., Bou Cabo, M., Boumaaza, J., Bouta, M., Boutonnet, C., Bouvet, G., Bouwhuis, M., Bozza, C., Brânzaş, H., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Caiffi, B., Caillat, L., Calvo, D., Campion, S., Capone, A., Carduner, H., Carretero, V., Castaldi, P., Celli, S., Cereseto, R., Chabab, M., Champion, C., Chau, N., Chen, A., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Colomer Molla, M., Colonges, S., Coniglione, R., Cosquer, A., Coyle, P., Cresta, M., Creusot, A., Cruz, A., Cuttone, G., D’amico, A., Dallier, R., Martino, B., Palma, M., Di Palma, I., Díaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Dörr, M., Drouhin, D., Eberl, T., Eddyamoui, A., Eeden, T., Eijk, D., El Bojaddaini, I., Eljarrari, H., Elsaesser, D., Enzenhöfer, A., Espinosa, V., Fermani, P., Ferrara, G., Filipović, M. D., Filippini, F., Fransen, J., Fusco, L. A., Gajanana, D., Gal, T., García Méndez, J., Garcia Soto, A., Garçon, E., Garufi, F., Gatius, C., Geißelbrecht, N., Gialanella, L., Giorgio, E., Gozzini, S. R., Gracia, R., Graf, K., Grella, G., Guderian, D., Guidi, C., Guillon, B., Gutiérrez, M., Haefner, J., Hallmann, S., Hamdaoui, H., Haren, H., Heijboer, A., Hekalo, A., Hennig, L., Henry, S., Hernández-Rey, J. J., Hofestädt, J., Huang, F., Idrissi Ibnsalih, W., Ilioni, A., Illuminati, G., James, C. W., Janezashvili, D., Jansweijer, P., Jong, M., Jong, P., Jung, B. J., Kadler, M., Kalaczyński, P., Kalekin, O., Katz, U. F., Kayzel, F., Keller, P., Khan Chowdhury, N. R., Kistauri, G., Knaap, F., Kooijman, P., Kouchner, A., Kreter, M., Kulikovskiy, V., Labalme, M., Lagier, P., Lahmann, R., Lamare, P., Lamoureux, M., Larosa, G., Lastoria, C., Laurence, J., Lazo, A., Le Breton, R., Le Guirriec, E., Le Stum, S., Lehaut, G., Leonardi, O., Leone, F., Leonora, E., Lerouvillois, C., Lesrel, J., Lessing, N., Levi, G., Lincetto, M., Lindsey Clark, M., Lipreau, T., Llorens Alvarez, C., Lonardo, A., Longhitano, F., Lopez-Coto, D., Lumb, N., Maderer, L., Majumdar, J., Mańczak, J., Margiotta, A., Marinelli, A., Marini, A., Martin, L., Martínez-Mora, J. A., Martini, A., Marzaioli, F., Mastroianni, S., Melis, K. W., Miele, G., Pasquale Migliozzi, Migneco, E., Mijakowski, P., Miranda, L. S., Mollo, C. M., Mongelli, M., Moussa, A., Muller, R., Musico, P., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Nkosi, B., Fearraigh, B. Ó, O’sullivan, M., Orlando, A., Ottonello, G., Ottonello, S., Palacios González, J., Papalashvili, G., Papaleo, R., Pastore, C., Păun, A. M., Păvălaş, G. E., Pellegrini, G., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Pieterse, C., Pisanti, O., Poirè, C., Popa, V., Pradier, T., Pratolongo, F., Probst, I., Pühlhofer, G., Pulvirenti, S., Quéméner, G., Randazzo, N., Rapicavoli, A., Razzaque, S., Real, D., Reck, S., Riccobene, G., Rigalleau, L., Romanov, A., Rovelli, A., Royon, J., Salesa Greus, F., Samtleben, D. F. E., Sánchez Losa, A., Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schmelling, J., Schnabel, J., Schneider, M. F., Schumann, J., Schutte, H. M., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Sinopoulou, A., Spisso, B., Spurio, M., Steijger, J., Stellacci, S. M., Taiuti, M., Tatone, F., Tayalati, Y., Tenllado, E., Tézier, D., Thakore, T., Theraube, S., Thiersen, H., Timmer, P., Tingay, S., Tsagkli, S., Tsourapis, V., Tzanetatos, D., Valieri, C., Elewyck, V., Vasileiadis, G., Versari, F., Viola, S., Vivolo, D., Wasseige, G., Wilms, J., Wojaczyński, R., Wolf, E., Yousfi, T., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zúñiga, J., Zywucka, N., Bianca Keilhauer, Alexander Kappes, Stavropoulos, D., Pestel, V., Aly, Z., Tzamariudaki, E., Markou, C., Ageron, M., Aiello, S., Albert, A., Alshamsi, M., Alves Garre, S., Ambrosone, A., Ameli, F., Andre, M., Androulakis, G., Anghinolfi, M., Anguita, M., Anton, G., Ardid, M., Ardid, S., Assal, W., Aublin, J., Bagatelas, C., Baret, B., Basegmez du Pree, S., Bendahman, M., Benfenati, F., Berbee, E., van den Berg, A. M., Bertin, V., Beurthey, S., van Beveren, V., Biagi, S., Billault, M., Bissinger, M., Boettcher, M., Bou Cabo, M., Boumaaza, J., Bouta, M., Boutonnet, C., Bouvet, G., Bouwhuis, M., Bozza, C., Branzas, H., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Caiffi, B., Caillat, L., Calvo, D., Campion, S., Capone, A., Carduner, H., Carretero, V., Castaldi, P., Celli, S., Cereseto, R., Chabab, M., Champion, C., Chau, N., Chen, A., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Colomer Molla, M., Colonges, S., Coniglione, R., Cosquer, A., Coyle, P., Cresta, M., Creusot, A., Cruz, A., Cuttone, G., D'Amico, A., Dallier, R., De Martino, B., De Palma, M., Di Palma, I., Diaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Dorr, M., Drouhin, D., Eberl, T., Eddyamoui, A., van Eeden, T., van Eijk, D., El Bojaddaini, I., Eljarrari, H., Elsaesser, D., Enzenhofer, A., Espinosa, V., Fermani, P., Ferrara, G., Filipovic, M. D., Filippini, F., Fransen, J., Fusco, L. A., Gajanana, D., Gal, T., Garcia Mendez, J., Garcia Soto, A., Garcon, E., Garufi, F., Gatius, C., Geisselbrecht, N., Gialanella, L., Giorgio, E., Gozzini, S. R., Gracia, R., Graf, K., Grella, G., Guderian, D., Guidi, C., Guillon, B., Gutierrez, M., Haefner, J., Hallmann, S., Hamdaoui, H., van Haren, H., Heijboer, A., Hekalo, A., Hennig, L., Henry, S., Hernandez-Rey, J. J., Hofestadt, J., Huang, F., Idrissi Ibnsalih, W., Ilioni, A., Illuminati, G., James, C. W., Janezashvili, D., Jansweijer, P., de Jong, M., de Jong, P., Jung, B. J., Kadler, M., Kalaczynski, P., Kalekin, O., Katz, U. F., Kayzel, F., Keller, P., Khan Chowdhury, N. R., Kistauri, G., van der Knaap, F., Kooijman, P., Kouchner, A., Kreter, M., Kulikovskiy, V., Labalme, M., Lagier, P., Lahmann, R., Lamare, P., Lamoureux, M., Larosa, G., Lastoria, C., Laurence, J., Lazo, A., Le Breton, R., Le Guirriec, E., Le Stum, S., Lehaut, G., Leonardi, O., Leone, F., Leonora, E., Lerouvillois, C., Lesrel, J., Lessing, N., Levi, G., Lincetto, M., Lindsey Clark, M., Lipreau, T., LLorens Alvarez, C., Lonardo, A., Longhitano, F., Lopez-Coto, D., Lumb, N., Maderer, L., Majumdar, J., Manczak, J., Margiotta, A., Marinelli, A., Marini, A., Martin, L., Martinez-Mora, J. A., Martini, A., Marzaioli, F., Mastroianni, S., Melis, K. W., Miele, G., Migliozzi, P., Migneco, E., Mijakowski, P., Miranda, L. S., Mollo, C. M., Mongelli, M., Moussa, A., Muller, R., Musico, P., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Nkosi, B., Fearraigh, B. O., O'Sullivan, M., Orlando, A., Ottonello, G., Ottonello, S., Palacios Gonzalez, J., Papalashvili, G., Papaleo, R., Pastore, C., Paun, A. M., Pavalas, G. E., Pellegrini, G., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Pieterse, C., Pisanti, O., Poire, C., Popa, V., Pradier, T., Pratolongo, F., Probst, I., Puhlhofer, G., Pulvirenti, S., Quemener, G., Randazzo, N., Rapicavoli, A., Razzaque, S., Real, D., Reck, S., Riccobene, G., Rigalleau, L., Romanov, A., Rovelli, A., Royon, J., Salesa Greus, F., Samtleben, D. F. E., Sanchez Losa, A., Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schmelling, J., Schnabel, J., Schneider, M. F., Schumann, J., Schutte, H. M., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Sinopoulou, A., Spisso, B., Spurio, M., Steijger, J., Stellacci, S. M., Taiuti, M., Tatone, F., Tayalati, Y., Tenllado, E., Tezier, D., Thakore, T., Theraube, S., Thiersen, H., Timmer, P., Tingay, S., Tsagkli, S., Tsourapis, V., Tzanetatos, D., Valieri, C., Van Elewyck, V., Vasileiadis, G., Versari, F., Viola, S., Vivolo, D., de Wasseige, G., Wilms, J., Wojaczynski, R., de Wolf, E., Yousfi, T., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zuniga, J., and Zywucka, N.
Abstract: KM3NeT is a research infrastructure aiming to study astrophysical sources as well as to perform particle physics studies, through the detection of neutrinos in the abyssal depths of the Mediterranean Sea. The KM3NeT/ORCA detector (Oscillation Research with Cosmics in the Abyss), currently under construction, is deployed at 2450 m depth near Toulon, France. It consists of vertical structures (Detection Units) equipped with spherical Digital Optical Modules, each hosting a set of photomultiplier tubes capable of detecting neutrino events from the Cherenkov radiation induced by the daughter particles. In this contribution, an analysis of data collected with the first 6 Detection Units (ORCA6) leading to a sample of atmospheric neutrino events is described. The angular resolution and the energy reconstruction performance for this event selection, which is a key factor for measuring the atmospheric neutrino flux are presented.
Published: 2022

99. Muon bundle reconstruction with KM3NeT/ORCA using graph convolutional networks

Author: Reck, S., Eberl, T., Katz, U., Ageron, M., Aiello, S., Albert, A., Alshamsi, M., Alves Garre, S., Aly, Z., Ambrosone, A., Ameli, F., Andre, M., Androulakis, G., Anghinolfi, M., Anguita, M., Anton, G., Ardid, M., Ardid, S., Assal, W., Aublin, J., Bagatelas, C., Baret, B., Basegmez Du Pree, S., Bendahman, M., Benfenati, F., Berbee, E., Den Berg, A. M., Bertin, V., Beurthey, S., Beveren, V., Biagi, S., Billault, M., Bissinger, M., Boettcher, M., Bou Cabo, M., Jihad BOUMAAZA, Bouta, M., Boutonnet, C., Bouvet, G., Bouwhuis, M., Bozza, C., Brânzaş, H., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Caiffi, B., Caillat, L., Calvo, D., Campion, S., Capone, A., Carduner, H., Carretero, V., Castaldi, P., Celli, S., Cereseto, R., Chabab, M., Champion, C., Chau, N., Chen, A., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Colomer Molla, M., Colonges, S., Coniglione, R., Cosquer, A., Coyle, P., Cresta, M., Creusot, A., Cruz, A., Cuttone, G., D’amico, A., Dallier, R., Martino, B., Palma, M., Di Palma, I., Díaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Dörr, M., Drouhin, D., Eddyamoui, A., Eeden, T., Eijk, D., El Bojaddaini, I., Eljarrari, H., Elsaesser, D., Enzenhöfer, A., Espinosa, V., Fermani, P., Ferrara, G., Filipović, M. D., Filippini, F., Fransen, J., Fusco, L. A., Gajanana, D., Gal, T., García Méndez, J., Garcia Soto, A., Garçon, E., Garufi, F., Gatius, C., Geißelbrecht, N., Gialanella, L., Giorgio, E., Gozzini, S. R., Gracia, R., Graf, K., Grella, G., Guderian, D., Guidi, C., Guillon, B., Gutiérrez, M., Haefner, J., Hallmann, S., Hamdaoui, H., Haren, H., Heijboer, A., Hekalo, A., Hennig, L., Henry, S., Hernández-Rey, J. J., Hofestädt, J., Huang, F., Idrissi Ibnsalih, W., Ilioni, A., Illuminati, G., James, C. W., Janezashvili, D., Jansweijer, P., Jong, M., Jong, P., Jung, B. J., Kadler, M., Kalaczyński, P., Kalekin, O., Katz, U. F., Kayzel, F., Keller, P., Khan Chowdhury, N. R., Kistauri, G., Knaap, F., Kooijman, P., Kouchner, A., Kreter, M., Kulikovskiy, V., Labalme, M., Lagier, P., Lahmann, R., Lamare, P., Lamoureux, M., Larosa, G., Lastoria, C., Laurence, J., Lazo, A., Le Breton, R., Le Guirriec, E., Le Stum, S., Lehaut, G., Leonardi, O., Leone, F., Leonora, E., Lerouvillois, C., Lesrel, J., Lessing, N., Levi, G., Lincetto, M., Lindsey Clark, M., Lipreau, T., Llorens Alvarez, C., Lonardo, A., Longhitano, F., Lopez-Coto, D., Lumb, N., Maderer, L., Majumdar, J., Mańczak, J., Margiotta, A., Marinelli, A., Marini, A., Markou, C., Martin, L., Martínez-Mora, J. A., Martini, A., Marzaioli, F., Mastroianni, S., Melis, K. W., Miele, G., Migliozzi, P., Migneco, E., Mijakowski, P., Miranda, L. S., Mollo, C. M., Mongelli, M., Moussa, A., Muller, R., Musico, P., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Nkosi, B., Fearraigh, B. Ó, O’sullivan, M., Orlando, A., Ottonello, G., Ottonello, S., Palacios González, J., Papalashvili, G., Papaleo, R., Pastore, C., Păun, A. M., Păvălaş, G. E., Pellegrini, G., Pellegrino, C., Perrin-Terrin, M., Pestel, V., Piattelli, P., Pieterse, C., Pisanti, O., Poirè, C., Popa, V., Pradier, T., Pratolongo, F., Probst, I., Pühlhofer, G., Pulvirenti, S., Quéméner, G., Randazzo, N., Rapicavoli, A., Razzaque, S., Real, D., Riccobene, G., Rigalleau, L., Romanov, A., Rovelli, A., Royon, J., Salesa Greus, F., Samtleben, D. F. E., Sánchez Losa, A., Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schmelling, J., Schnabel, J., Schneider, M. F., Schumann, J., Schutte, H. M., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Steijger, J., Stellacci, S. M., Taiuti, M., Tatone, F., Tayalati, Y., Tenllado, E., Tézier, D., Thakore, T., Theraube, S., Thiersen, H., Timmer, P., Tingay, S., Tsagkli, S., Tsourapis, V., Tzamariudaki, E., Tzanetatos, D., Valieri, C., Elewyck, V., Vasileiadis, G., Versari, F., Viola, S., Vivolo, D., Wasseige, G., Wilms, J., Wojaczyński, R., Wolf, E., Yousfi, T., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zúñiga, J., Zywucka, N., Bianca Keilhauer, Alexander Kappes, Reck, S., Eberl, T., Katz, U., Ageron, M., Aiello, S., Albert, A., Alshamsi, M., Alves Garre, S., Aly, Z., Ambrosone, A., Ameli, F., Andre, M., Androulakis, G., Anghinolfi, M., Anguita, M., Anton, G., Ardid, M., Ardid, S., Assal, W., Aublin, J., Bagatelas, C., Baret, B., Basegmez du Pree, S., Bendahman, M., Benfenati, F., Berbee, E., van den Berg, A. M., Bertin, V., Beurthey, S., van Beveren, V., Biagi, S., Billault, M., Bissinger, M., Boettcher, M., Bou Cabo, M., Boumaaza, J., Bouta, M., Boutonnet, C., Bouvet, G., Bouwhuis, M., Bozza, C., Branzas, H., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Caiffi, B., Caillat, L., Calvo, D., Campion, S., Capone, A., Carduner, H., Carretero, V., Castaldi, P., Celli, S., Cereseto, R., Chabab, M., Champion, C., Chau, N., Chen, A., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Colomer Molla, M., Colonges, S., Coniglione, R., Cosquer, A., Coyle, P., Cresta, M., Creusot, A., Cruz, A., Cuttone, G., D'Amico, A., Dallier, R., De Martino, B., De Palma, M., Di Palma, I., Diaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Dorr, M., Drouhin, D., Eddyamoui, A., van Eeden, T., van Eijk, D., El Bojaddaini, I., Eljarrari, H., Elsaesser, D., Enzenhofer, A., Espinosa, V., Fermani, P., Ferrara, G., Filipovic, M. D., Filippini, F., Fransen, J., Fusco, L. A., Gajanana, D., Gal, T., Garcia Mendez, J., Garcia Soto, A., Garcon, E., Garufi, F., Gatius, C., Geisselbrecht, N., Gialanella, L., Giorgio, E., Gozzini, S. R., Gracia, R., Graf, K., Grella, G., Guderian, D., Guidi, C., Guillon, B., Gutierrez, M., Haefner, J., Hallmann, S., Hamdaoui, H., van Haren, H., Heijboer, A., Hekalo, A., Hennig, L., Henry, S., Hernandez-Rey, J. J., Hofestadt, J., Huang, F., Idrissi Ibnsalih, W., Ilioni, A., Illuminati, G., James, C. W., Janezashvili, D., Jansweijer, P., de Jong, M., de Jong, P., Jung, B. J., Kadler, M., Kalaczynski, P., Kalekin, O., Katz, U. F., Kayzel, F., Keller, P., Khan Chowdhury, N. R., Kistauri, G., van der Knaap, F., Kooijman, P., Kouchner, A., Kreter, M., Kulikovskiy, V., Labalme, M., Lagier, P., Lahmann, R., Lamare, P., Lamoureux, M., Larosa, G., Lastoria, C., Laurence, J., Lazo, A., Le Breton, R., Le Guirriec, E., Le Stum, S., Lehaut, G., Leonardi, O., Leone, F., Leonora, E., Lerouvillois, C., Lesrel, J., Lessing, N., Levi, G., Lincetto, M., Lindsey Clark, M., Lipreau, T., LLorens Alvarez, C., Lonardo, A., Longhitano, F., Lopez-Coto, D., Lumb, N., Maderer, L., Majumdar, J., Manczak, J., Margiotta, A., Marinelli, A., Marini, A., Markou, C., Martin, L., Martinez-Mora, J. A., Martini, A., Marzaioli, F., Mastroianni, S., Melis, K. W., Miele, G., Migliozzi, P., Migneco, E., Mijakowski, P., Miranda, L. S., Mollo, C. M., Mongelli, M., Moussa, A., Muller, R., Musico, P., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Nkosi, B., Fearraigh, B. O., O'Sullivan, M., Orlando, A., Ottonello, G., Ottonello, S., Palacios Gonzalez, J., Papalashvili, G., Papaleo, R., Pastore, C., Paun, A. M., Pavalas, G. E., Pellegrini, G., Pellegrino, C., Perrin-Terrin, M., Pestel, V., Piattelli, P., Pieterse, C., Pisanti, O., Poire, C., Popa, V., Pradier, T., Pratolongo, F., Probst, I., Puhlhofer, G., Pulvirenti, S., Quemener, G., Randazzo, N., Rapicavoli, A., Razzaque, S., Real, D., Riccobene, G., Rigalleau, L., Romanov, A., Rovelli, A., Royon, J., Salesa Greus, F., Samtleben, D. F. E., Sanchez Losa, A., Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schmelling, J., Schnabel, J., Schneider, M. F., Schumann, J., Schutte, H. M., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Steijger, J., Stellacci, S. M., Taiuti, M., Tatone, F., Tayalati, Y., Tenllado, E., Tezier, D., Thakore, T., Theraube, S., Thiersen, H., Timmer, P., Tingay, S., Tsagkli, S., Tsourapis, V., Tzamariudaki, E., Tzanetatos, D., Valieri, C., Van Elewyck, V., Vasileiadis, G., Versari, F., Viola, S., Vivolo, D., de Wasseige, G., Wilms, J., Wojaczynski, R., de Wolf, E., Yousfi, T., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zuniga, J., and Zywucka, N.
Abstract: KM3NeT/ORCA is a water-Cherenkov neutrino detector, currently under construction in the Mediterranean Sea at a depth of 2450 meters. The project’s main goal is the determination of the neutrino mass hierarchy by measuring the energy- and zenith-angle-resolved oscillation probabilities of atmospheric neutrinos traversing the Earth. Additionally, the detector observes a large amount of atmospheric muons, which can be used to study extensive air showers generated by cosmic ray particles. This work describes a deep-learning based reconstruction of atmospheric muons using graph convolutional networks. They are used to reconstruct the zenith angle, the muon multiplicity and the diameter of atmospheric muon bundles. Simulations and measured data from an early four line stage of the detector are used to evaluate the performance. Furthermore, the reconstructions are compared to the ones of classical approaches, and use cases for the indirect study of cosmic ray particles are shown.
Published: 2022

100. Expectations for the high-energy neutrino detection from starburst galaxies with KM3NeT/ARCA

Author: Ibnsalih, W. I., Ambrosone, A., Marinelli, A., Miele, G., Migliozzi, P., Pisanti, O., Sharma, A., Ageron, M., Aiello, S., Albert, A., Alshamsi, M., Alves Garre, S., Aly, Z., Ameli, F., Andre, M., Androulakis, G., Anghinolfi, M., Anguita, M., Anton, G., Ardid, M., Ardid, S., Assal, W., Aublin, J., Bagatelas, C., Baret, B., Basegmez Du Pree, S., Bendahman, M., Benfenati, F., Berbee, E., Den Berg, A. M., Bertin, V., Beurthey, S., Beveren, V., Biagi, S., Billault, M., Bissinger, M., Boettcher, M., Bou Cabo, M., Boumaaza, J., Bouta, M., Boutonnet, C., Bouvet, G., Bouwhuis, M., Bozza, C., Brânzaş, H., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Caiffi, B., Caillat, L., Calvo, D., Campion, S., Capone, A., Carduner, H., Carretero, V., Castaldi, P., Celli, S., Cereseto, R., Chabab, M., Champion, C., Chau, N., Chen, A., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Colomer Molla, M., Colonges, S., Coniglione, R., Cosquer, A., Coyle, P., Cresta, M., Creusot, A., Cruz, A., Cuttone, G., D’amico, A., Dallier, R., Martino, B., Palma, M., Di Palma, I., Díaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Dörr, M., Drouhin, D., Eberl, T., Eddyamoui, A., Eeden, T., Eijk, D., El Bojaddaini, I., Eljarrari, H., Elsaesser, D., Enzenhöfer, A., Espinosa, V., Fermani, P., Ferrara, G., Filipović, M. D., Filippini, F., Fransen, J., Fusco, L. A., Gajanana, D., Gal, T., García Méndez, J., Garcia Soto, A., Garçon, E., Garufi, F., Gatius, C., Geißelbrecht, N., Gialanella, L., Giorgio, E., Gozzini, S. R., Gracia, R., Graf, K., Grella, G., Guderian, D., Guidi, C., Guillon, B., Gutiérrez, M., Haefner, J., Steffen Hallmann, Hamdaoui, H., Haren, H., Heijboer, A., Hekalo, A., Hennig, L., Henry, S., Hernández-Rey, J. J., Hofestädt, J., Huang, F., Idrissi Ibnsalih, W., Ilioni, A., Illuminati, G., James, C. W., Janezashvili, D., Jansweijer, P., Jong, M., Jong, P., Jung, B. J., Kadler, M., Kalaczyński, P., Kalekin, O., Katz, U. F., Kayzel, F., Keller, P., Khan Chowdhury, N. R., Kistauri, G., Knaap, F., Kooijman, P., Kouchner, A., Kreter, M., Kulikovskiy, V., Labalme, M., Lagier, P., Lahmann, R., Lamare, P., Lamoureux, M., Larosa, G., Lastoria, C., Laurence, J., Lazo, A., Le Breton, R., Le Guirriec, E., Le Stum, S., Lehaut, G., Leonardi, O., Leone, F., Leonora, E., Lerouvillois, C., Lesrel, J., Lessing, N., Levi, G., Lincetto, M., Lindsey Clark, M., Lipreau, T., Llorens Alvarez, C., Lonardo, A., Longhitano, F., Lopez-Coto, D., Lumb, N., Maderer, L., Majumdar, J., Mańczak, J., Margiotta, A., Marini, A., Markou, C., Martin, L., Martínez-Mora, J. A., Martini, A., Marzaioli, F., Mastroianni, S., Melis, K. W., Migneco, E., Mijakowski, P., Miranda, L. S., Mollo, C. M., Mongelli, M., Moussa, A., Muller, R., Musico, P., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Nkosi, B., Fearraigh, B. Ó, O’sullivan, M., Orlando, A., Ottonello, G., Ottonello, S., Palacios González, J., Papalashvili, G., Papaleo, R., Pastore, C., Păun, A. M., Păvălaş, G. E., Pellegrini, G., Pellegrino, C., Perrin-Terrin, M., Pestel, V., Piattelli, P., Pieterse, C., Poirè, C., Popa, V., Pradier, T., Pratolongo, F., Probst, I., Pühlhofer, G., Pulvirenti, S., Quéméner, G., Randazzo, N., Rapicavoli, A., Razzaque, S., Real, D., Reck, S., Riccobene, G., Rigalleau, L., Romanov, A., Rovelli, A., Royon, J., Salesa Greus, F., Samtleben, D. F. E., Sánchez Losa, A., Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schmelling, J., Schnabel, J., Schneider, M. F., Schumann, J., Schutte, H. M., Seneca, J., Sgura, I., Shanidze, R., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Steijger, J., Stellacci, S. M., Taiuti, M., Tatone, F., Tayalati, Y., Tenllado, E., Tézier, D., Thakore, T., Theraube, S., Thiersen, H., Timmer, P., Tingay, S., Tsagkli, S., Tsourapis, V., Tzamariudaki, E., Tzanetatos, D., Valieri, C., Elewyck, V., Vasileiadis, G., Versari, F., Viola, S., Vivolo, D., Wasseige, G., Wilms, J., Wojaczyński, R., Wolf, E., Yousfi, T., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zúñiga, J., Zywucka, N., Bianca Keilhauer, Alexander Kappes, Ibnsalih, W. I., Ambrosone, A., Marinelli, A., Miele, G., Migliozzi, P., Pisanti, O., Sharma, A., Ageron, M., Aiello, S., Albert, A., Alshamsi, M., Alves Garre, S., Aly, Z., Ameli, F., Andre, M., Androulakis, G., Anghinolfi, M., Anguita, M., Anton, G., Ardid, M., Ardid, S., Assal, W., Aublin, J., Bagatelas, C., Baret, B., Basegmez du Pree, S., Bendahman, M., Benfenati, F., Berbee, E., van den Berg, A. M., Bertin, V., Beurthey, S., van Beveren, V., Biagi, S., Billault, M., Bissinger, M., Boettcher, M., Bou Cabo, M., Boumaaza, J., Bouta, M., Boutonnet, C., Bouvet, G., Bouwhuis, M., Bozza, C., Branzas, H., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Caiffi, B., Caillat, L., Calvo, D., Campion, S., Capone, A., Carduner, H., Carretero, V., Castaldi, P., Celli, S., Cereseto, R., Chabab, M., Champion, C., Chau, N., Chen, A., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Colomer Molla, M., Colonges, S., Coniglione, R., Cosquer, A., Coyle, P., Cresta, M., Creusot, A., Cruz, A., Cuttone, G., D'Amico, A., Dallier, R., De Martino, B., De Palma, M., Di Palma, I., Diaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Dorr, M., Drouhin, D., Eberl, T., Eddyamoui, A., van Eeden, T., van Eijk, D., El Bojaddaini, I., Eljarrari, H., Elsaesser, D., Enzenhofer, A., Espinosa, V., Fermani, P., Ferrara, G., Filipovic, M. D., Filippini, F., Fransen, J., Fusco, L. A., Gajanana, D., Gal, T., Garcia Mendez, J., Garcia Soto, A., Garcon, E., Garufi, F., Gatius, C., Geisselbrecht, N., Gialanella, L., Giorgio, E., Gozzini, S. R., Gracia, R., Graf, K., Grella, G., Guderian, D., Guidi, C., Guillon, B., Gutierrez, M., Haefner, J., Hallmann, S., Hamdaoui, H., van Haren, H., Heijboer, A., Hekalo, A., Hennig, L., Henry, S., Hernandez-Rey, J. J., Hofestadt, J., Huang, F., Idrissi Ibnsalih, W., Ilioni, A., Illuminati, G., James, C. W., Janezashvili, D., Jansweijer, P., de Jong, M., de Jong, P., Jung, B. J., Kadler, M., Kalaczynski, P., Kalekin, O., Katz, U. F., Kayzel, F., Keller, P., Khan Chowdhury, N. R., Kistauri, G., van der Knaap, F., Kooijman, P., Kouchner, A., Kreter, M., Kulikovskiy, V., Labalme, M., Lagier, P., Lahmann, R., Lamare, P., Lamoureux, M., Larosa, G., Lastoria, C., Laurence, J., Lazo, A., Le Breton, R., Le Guirriec, E., Le Stum, S., Lehaut, G., Leonardi, O., Leone, F., Leonora, E., Lerouvillois, C., Lesrel, J., Lessing, N., Levi, G., Lincetto, M., Lindsey Clark, M., Lipreau, T., LLorens Alvarez, C., Lonardo, A., Longhitano, F., Lopez-Coto, D., Lumb, N., Maderer, L., Majumdar, J., Manczak, J., Margiotta, A., Marini, A., Markou, C., Martin, L., Martinez-Mora, J. A., Martini, A., Marzaioli, F., Mastroianni, S., Melis, K. W., Migneco, E., Mijakowski, P., Miranda, L. S., Mollo, C. M., Mongelli, M., Moussa, A., Muller, R., Musico, P., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Nkosi, B., Fearraigh, B. O., O'Sullivan, M., Orlando, A., Ottonello, G., Ottonello, S., Palacios Gonzalez, J., Papalashvili, G., Papaleo, R., Pastore, C., Paun, A. M., Pavalas, G. E., Pellegrini, G., Pellegrino, C., Perrin-Terrin, M., Pestel, V., Piattelli, P., Pieterse, C., Poire, C., Popa, V., Pradier, T., Pratolongo, F., Probst, I., Puhlhofer, G., Pulvirenti, S., Quemener, G., Randazzo, N., Rapicavoli, A., Razzaque, S., Real, D., Reck, S., Riccobene, G., Rigalleau, L., Romanov, A., Rovelli, A., Royon, J., Salesa Greus, F., Samtleben, D. F. E., Sanchez Losa, A., Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schmelling, J., Schnabel, J., Schneider, M. F., Schumann, J., Schutte, H. M., Seneca, J., Sgura, I., Shanidze, R., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Steijger, J., Stellacci, S. M., Taiuti, M., Tatone, F., Tayalati, Y., Tenllado, E., Tezier, D., Thakore, T., Theraube, S., Thiersen, H., Timmer, P., Tingay, S., Tsagkli, S., Tsourapis, V., Tzamariudaki, E., Tzanetatos, D., Valieri, C., Van Elewyck, V., Vasileiadis, G., Versari, F., Viola, S., Vivolo, D., de Wasseige, G., Wilms, J., Wojaczynski, R., de Wolf, E., Yousfi, T., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zuniga, J., and Zywucka, N.
Abstract: Star-forming galaxies (SFGs) and starburst galaxies (SBGs) are extragalactic sources which could produce high-energy neutrinos. In principle, they could play a rather important role for explaining at least a sizeable part of IceCube’s observations of astophysical neutrino. Using a recent theoretical model which implemented a blending of spectral indeces, we present the KM3NeT/ARCA sensitivities for such a diffuse flux from the startburst galaxies. In particular, we provide the 5-year differential sensitivity for the two building blocks of ARCA. We make use only of the track-like events in the range of 100 GeV - 10 PeV differentiate in 11 bins of energy. We show how the upcoming neutrino telescope could observe the diffuse SFG and SBG within 5 years of data taking. We found the minimum of the sensitivity at around 100 TeV, which is also the energy where the SBG contribution is expected to peak. This would not only constrain the multi-component fit of the observed astrophysical neutrino flux at that energy (100 TeV), but would also provide us a direct link between the star-forming activity in the reservoir environments and the hadronic emissions.
Published: 2022

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