Search

The present work aims to investigate the integration into renewable energy communities (REC) schemes of micro and mini- Combined Heat and Power (CHP) plants. In detail, it has been evaluated the minimum self-consumption (SC) share needed to even out the revenues coming from the energy efficiency certificates (EECs). In order to establish a SC based tariff for CHP plants a correlation between SC share and the tariff value has been assessed for different commercial plants. A 70% of SC share has been set as a minimum target, which is related to incentive rates of 53 and 39.5 €/MWh, for mini and micro-CHPs, respectively. These values are about 65% lower than the current tariffs set by ARERA (Italian Regulatory Authority for Energy, Networks and Environment) to reward the renewable energy SC. A real building and two CHP plants have been considered as reference case studies. A dynamic simulation has been carried out in order to analyse the proposed incentive scheme in a real application. Starting from a 3-D BIM model, the energy flows have been calculated over one year period. Finally, it has been demonstrated how a SC based tariff can significantly reduce the share of injected electricity into the grid, also promoting the thermal carrier sharing. In so doing, the renewable energy sources intermittency can be easily mitigated and balanced, avoiding additional burdens on public expenditure.

Climate change is a worldwide recognized problem, and its mitigation identified as one of the most significant challenges. The way to achieve this purpose is to reduce greenhouse gases (GHG) emissions through the energy system using renewables. The change from an energy system based on fossil fuels to renewable sources-based one is necessary on which the world community agrees. A photovoltaic thermal (PV/T) panel is a system that can produce both electricity and thermal energy simultaneously in one integrated system. This paper deals with hybrid energy systems, specifically a hybrid system to produce power and thermal energy from solar sources consisting of photovoltaic thermal modules. The hybrid system consists of 7 hybrid photovoltaic panels installed on the roof of the laboratory. This paper presents a study for experimental data obtained from a measurement campaign of the thermal and electrical behavior of a PV/T system in single and series models.

Cet article a pour objectif d’apporter une réflexion méthodologique sur l’exploitation des numérisations d’un site archéologique de grande échelle. Basées sur un grand volume de données issues de relevés photogrammétriques et GPR aériens, ces numérisations sont bien souvent utilisées pour l’enregistrement de l’état du bâti au moment de l’acquisition ou la prospection archéologique. Notre approche propose d’étendre l’exploitation de ces types de données massives afin d’enrichir la connaissance des logiques de conception urbaine d’une « cité » dont il ne reste que certaines parties monumentales encore visible aujourd’hui. En outre, les méthodes d’analyse urbaine s’appuient largement sur une compréhension occidentale de la ville qui est parfois très éloignée de celle que l’on rencontre en Amérique du sud avant l’arrivée des conquistadors. Au-delà des enjeux de connaissances spécifiques au terrain d’étude, l’ambition première de cet article est de comprendre comment l’apport et l’exploitation des technologies présentes et futures en matière de numérisation patrimoniale pourraient nous aider à accroître notre connaissance du passé. En somme se projeter dans le futur pour opérer un retour vers le passé.

To date, Sliding Vane Pump (SVP) technology is one of the most attractive solution in different technical applications thanks to its reliability and compactness and capability to keep a high efficiency even when it is working far from rated condition. In particular, this feature makes the SVP suitable to be employed for the oil circulation (SVOP) in Internal Combustion Engine (ICE) which is characterized by a wide oil flow rates variation, delivered pressure and temperature variation which causes operating conditions of the pump far from the design point. Flow delivered changes in these machines are produced by varying the eccentricity for a mechanical connection with the engine - or by varying the speed of revolution. The mild hybridization of the powertrains calls for a strong development of electrically assisted engine auxiliaries which undoubtedly makes the flow variations easier to be done, but the presence of an electric motor requires some technological choices not fully assessed, a cost increase and a reliability decrease. The paper presents a mathematical model of a SVOP for oil circulation in ICE, suitably validated by a wide experimental activity. The model integrates a mono and zero-dimensional fluid-dynamic analysis and allows to represent the intimate behaviour of the machine. Moreover, it was employed as virtual platform to discuss pros and cons of different flow rate variation strategies and their effect on the efficiency of the SVOP.

This study deals with the implementation of an analytical model to simulate the energy performance associated to a commercial Gas adsorption Heat Pump, when H2NG (Hydrogen Enriched Natural Gas) blends are used as fuel. In detail, a water source heat pump manufactured by Robur (GAHP-WS) has been used as a reference device for building the simulation model within the MATLAB-Simulink environment. Thereafter, the simulation results have been validated by the experimental campaign, testing on field and in actual operating conditions the heat pump. Specifically, the model has been developed by implementing the WaterAmmonia mass and energy balances for each component. It is able to evaluate fuel consumption, efficiency in terms of GUE, required thermal power from the cold heat sink as well as the water outlet temperature at the evaporator, once the heating load is used as the main input. The experimental campaign for the model calibration and validation has been carried out over the winter season. Additionally, the heat pump performance has been detected when it operates to supply hot water at 60 °C and 55 °C, and it is fuelled with growing hydrogen fractions, starting from 0% vol., 5% vol. up to 10% vol. In the end, the standard errors as well as the relative ones affecting the main output parameters have computed for the validation process. From the outcomes it emerges that the average relative standard error related to all load conditions is lower than 2.5% for natural gas operation. On the contrary, it ranges between 2.5% and 4% when H2NG at 5% and 10% by volume have been burnt.

The growing penetration of non-programmable energy sources will largely contribute to intensify the renewable capacity firming issues. Providing a higher systems flexibility, i.e. the ability to match the supply and the demand sides as much as possible, is the main challenge to cope with, by adopting new energy planning paradigms. In this framework, different combined strategies, aiming at efficiently integrating that large amount of variable RES (VRES), have to be implemented. In the recent years, the Smart Energy Systems (SES) concept has been introduced to overcome the single-sector approach, promoting a holistic and integrated vision. By that approach, it is possible to exploit synergies between different energy sectors so as to identify the best technical options to globally reduce the primary fossil energy consumption. Starting from a quantitative and qualitative analysis of the most recent international studies dealing with the SES approach, the aim of this paper is to critically review and analyse the role of the main potential flexibility measures applied in the energy planning sector. In detail, Power-to-X and Demand Side Management (DSM) application have been considered, highlighting strengths and weaknesses of such strategies to accomplish the ambitious target of 100% renewable. From this literature review, it emerges how a single strategy adoption is not enough to guarantee the required flexibility level for the whole energy system. Indeed, the best configuration can be attained by integrating different options matching all the external constraints.

Kai-Feng Xu,1 Bee Hong Lo2 1Department of Respiratory Medicine, Peking Union Medical College Hospital, Beijing, People's Republic of China; 2Developmental Pediatrician, PECAT, Children's Hospital Westmead, Sydney, NSW, Australia Abstract: Lymphangioleiomyomatosis (LAM) is an uncommon disease presented as diffuse thin-walled cystic changes in the lung. The main differential diagnoses include pulmonary Langerhans' histiocytosis (PLCH), Birt-Hogg-Dubé syndrome (BHD), lymphoid interstitial pneumonia (LIP), and amyloidosis. A combination of clinical, radiological, and pathological approaches as well as genetic testing will clarify the diagnosis in most cases. LAM is a disease almost exclusively in women. Dyspnea, pneumothorax, and hemoptysis are common presentations in LAM patients. LAM is also a lymphatic disorder affecting lymphatic vessels and lymph nodes. Chylothorax, chylous ascites, and lymphangiomyomas are frequently seen. LAM can present sporadically as a single entity or as part of tuberous sclerosis complex (TSC). Angiomyolipoma (AML) is a characteristic extra-pulmonary lesion, either found in association with sporadic or TSC-related LAM. High-risk populations should be screened for LAM, including adult women with TSC and female patients with spontaneous pneumothorax, AMLs in the kidney, and diffuse cystic lung diseases. Definitive diagnosis of LAM is based on a high level of clinical suspicion on presentation supported by pathological findings or by a distinct feature, such as a history of TSC, AMLs in the kidney, chylothorax, or chylous ascites. Vascular endothelial growth factor-D (VEGF-D) in serum is a noninvasive and reliable diagnostic biomarker. In experienced centers, trans-bronchial lung biopsy (TBLB) provides a convenient and safe way to obtain lung specimens for diagnostic purposes. An effective treatment for LAM is now available, namely using a mechanistic target of rapamycin (mTOR) inhibitor such as sirolimus. Efficacy of sirolimus has been confirmed in clinical trials. Research in other molecular-targeted therapies is under investigation. A previously little-known rare disease with no cure is now better understood with regards to its pathogenesis, diagnosis, and management. In this review, current knowledge in diagnosis and differential diagnosis of LAM will be discussed, followed by the discussion of therapy with mTOR inhibitors. Keywords: lymphangioleiomyomatosis, diffuse cystic lung diseases, tuberous sclerosis complex, vascular endothelial growth factor-D, sirolimus

The EU gyrotron for the ITER Electron Cyclotron (EC) heating system has been developed in coordinated efforts of the EGYC Consortium, Thales ED (TED) and Fusion for Energy (F4E) and under the supervision of ITER Organization Central Team. After the successful verification of the design of the 1MW, 170 GHz hollow cylindrical cavity gyrotron operating at the nominal TE32,9 mode with a short pulse gyrotron prototype at KIT, an industrial CW gyrotron prototype was manufactured by TED and tested at ~0.8 MW output power and 180 s pulse duration, which is the limit of the HV power supply currently available at KIT. The experiments are being continued at SPC in 2018 to extend further the pulse duration, taking advantage of the existing CW full-power capabilities of the gyrotron test facility recently upgraded for the FALCON project. The gyrotron cavity interaction is very sensitive to the alignment of the internal mechanical parts of the gyrotron tube with the magnetic field generated by the superconducting magnet within a typical range of 0.2 – 0.5 mm. The control of the tolerances and deformations becomes therefore critical to achieving the target performances. With the EU gyrotron prototype it was possible to adjust the alignment of the gyrotron tube with respect to the magnetic field axis during the installation and commissioning phase. The actual shift and tilt movements were verified using advanced metrology methods such as photogrammetry. In this paper, the alignment control techniques and procedures will be discussed also in view of enhancing the reproducibility of gyrotron performance during series production.

Abstract Background The detection of insulin autoantibodies (IAA) aids in the prediction of autoimmune diabetes development. However, the long-standing, gold standard 125I-insulin radiobinding assay (RBA) has low reproducibility between laboratories, long sample processing times and requires the use of newly synthesized radiolabeled insulin for each set of assays. Therefore, a rapid, non-radioactive, and reproducible assay is highly desirable. Methods We have developed electrochemiluminescence (ECL)-based assays that fulfill these criteria in the measurement of IAA and anti-insulin antibodies (IA) in non-obese diabetic (NOD) mice and in type 1 diabetic individuals, respectively. Using the murine IAA ECL assay, we examined the correlation between IAA, histopathological insulitis, and blood glucose in a cohort of female NOD mice from 4 up to 36 weeks of age. We developed a human IA ECL assay that we compared to conventional RBA and validated using samples from 34 diabetic and 59 non-diabetic individuals in three independent laboratories. Results Our ECL assays were rapid and sensitive with a broad dynamic range and low background. In the NOD mouse model, IAA levels measured by ECL were positively correlated with insulitis severity, and the values measured at 8-10 weeks of age were predictive of diabetes onset. Using human serum and plasma samples, our IA ECL assay yielded reproducible and accurate results with an average sensitivity of 84% at 95% specificity with no statistically significant difference between laboratories. Conclusions These novel, non-radioactive ECL-based assays should facilitate reliable and fast detection of antibodies to insulin and its precursors sera and plasma in a standardized manner between laboratories in both research and clinical settings. Our next step is to evaluate the human IA assay in the detection of IAA in prediabetic subjects or those at risk of type 1 diabetes and to develop similar assays for other autoantibodies that together are predictive for the diagnosis of this common disorder, in order to improve prediction and facilitate future therapeutic trials.

Abstract Background Genome-wide mapping of protein-DNA interactions has been widely used to investigate biological functions of the genome. An important question is to what extent such interactions are regulated at the DNA sequence level. However, current investigation is hampered by the lack of computational methods for systematic evaluating sequence specificity. Results We present a simple, unbiased quantitative measure for DNA sequence specificity called the Motif Independent Measure (MIM). By analyzing both simulated and real experimental data, we found that the MIM measure can be used to detect sequence specificity independent of presence of transcription factor (TF) binding motifs. We also found that the level of specificity associated with H3K4me1 target sequences is highly cell-type specific and highest in embryonic stem (ES) cells. We predicted H3K4me1 target sequences by using the N- score model and found that the prediction accuracy is indeed high in ES cells.The software to compute the MIM is freely available at: https://github.com/lucapinello/mim. Conclusions Our method provides a unified framework for quantifying DNA sequence specificity and serves as a guide for development of sequence-based prediction models.

Abstract This study reports for the first time on the distribution, host preference and infection rates of malaria vectors in Mauritania. It was conducted during an outbreak of Rift valley fever. Three anopheline species were reported. An. arabiensis was the predominant species observed in all regions whereas An. pharoensis and An. funestus were observed along the south border in the Senegal River valley where extensive irrigation schemes are present. The distribution limits of anopheline species were observed from the Senegal River basin in the Trarza region up to the south limit of the Saharan desert in Tidjikja city. Overall, all An. funestus and An. pharoensis were fed respectively on human and ovine hosts whereas the mean anthropophilic rate of An. gambiae s.l. was 53%. A low Plasmodium falciparum infection rate was observed for species of the An. gambiae complex (0.17%) represented mainly by An. arabiensis. Because of the specific nature of this investigation, longitudinal studies are essential to better characterize the malaria vectors and their respective role in malaria transmission.

Abstract Background Human monoclonal antibodies (mAbs) generated as a result of the immune response are likely to be the most effective therapeutic antibodies, particularly in the case of infectious diseases against which the immune response is protective. Human cytomegalovirus (HCMV) is an ubiquitous opportunistic virus that is the most serious pathogenic agent in transplant patients. The available therapeutic armamentarium (e.g. HCMV hyperimmune globulins or antivirals) is associated with severe side effects and the emergence of drug-resistant strains; therefore, neutralizing human mAb may be a decisive alternative in the prevention of primary and re-activated HCMV infections in these patients. Results The purpose of this study was to generate neutralizing mAb against HCMV from the immunological repertoire of immune donors. To this aim, we designed an efficient technology relying on two discrete and sequential steps: first, human B-lymphocytes are stimulated with TLR9-agonists and IL-2; second, after both additives are removed, the cells are infected with EBV. Using this strategy we obtained 29 clones secreting IgG neutralizing the HCMV infectivity; four among these were further characterized. All of the mAbs neutralize the infection in different combinations of HCMV strains and target cells, with a potency ~20 fold higher than that of the HCMV hyperimmune globulins, currently used in transplant recipients. Recombinant human monoclonal IgG1 suitable as a prophylactic or therapeutic tool in clinical applications has been generated. Conclusion The technology described has proven to be more reproducible, efficient and rapid than previously reported techniques, and can be adopted at low overall costs by any cell biology laboratory for the development of fully human mAbs for immunotherapeutic uses.

Abstract Background Little attention has been paid to the consequences of the last landbridge between Africa and Sicily on Mediterranean biogeography. Previous paleontological and scarce molecular data suggest possible faunal exchange later than the well-documented landbridge in the Messinian (5.3 My); however, a possible African origin of recent terrestrial Sicilian fauna has not been thoroughly tested with molecular methods. To gain insight into the phylogeography of the region, we examine two mitochondrial and two nuclear markers (one is a newly adapted intron marker) in green toads (Bufo viridis subgroup) across that sea barrier, the Strait of Sicily. Results Extensive sampling throughout the western Mediterranean and North Africa revealed a deep sister relationship between Sicilian (Bufo siculus n.sp.) and African green toads (B. boulengeri) on the mitochondrial and nuclear level. Divergence times estimated under a Bayesian-coalescence framework (mtDNA control region and 16S rRNA) range from the Middle Pliocene (3.6 My) to Pleistocene (0.16 My) with an average (1.83 to 2.0 My) around the Pliocene/Pleistocene boundary, suggesting possible land connections younger than the Messinian (5.3 My). We describe green toads from Sicily and some surrounding islands as a new endemic species (Bufo siculus). Bufo balearicus occurs on some western Mediterranean islands (Corsica, Sardinia, Mallorca, and Menorca) and the Apennine Peninsula, and is well differentiated on the mitochondrial and nuclear level from B. siculus as well as from B. viridis (Laurenti), whose haplotype group reaches northeastern Italy, north of the Po River. Detection of Calabrian B. balearicus haplotypes in northeastern Sicily suggests recent invasion. Our data agree with paleogeographic and fossil data, which suggest long Plio-Pleistocene isolation of Sicily and episodic Pleistocene faunal exchange across the Strait of Messina. It remains unknown whether both species (B. balearicus, B. siculus) occur in sympatry in northern Sicily. Conclusion Our findings on green toads give the first combined mitochondrial and nuclear sequence evidence for a phylogeographic connection across the Strait of Sicily in terrestrial vertebrates. These relationships may have implications for comparative phylogeographic research on other terrestrial animals co-occurring in North Africa and Sicily.

Abstract Background Shared decision-making has been advocated; however there are relatively few studies on physician preferences for, and experiences of, different styles of clinical decision-making as most research has focused on patient preferences and experiences. The objectives of this study were to determine 1) physician preferences for different styles of clinical decision-making; 2) styles of clinical decision-making physicians perceive themselves as practicing; and 3) the congruence between preferred and perceived style. In addition we sought to determine physician perceptions of the availability of time in visits, and their role in encouraging patients to look for health information. Methods Cross-sectional survey of a nationally representative sample of U.S. physicians. Results 1,050 (53% response rate) physicians responded to the survey. Of these, 780 (75%) preferred to share decision-making with their patients, 142 (14%) preferred paternalism, and 118 (11%) preferred consumerism. 87% of physicians perceived themselves as practicing their preferred style. Physicians who preferred their patients to play an active role in decision-making were more likely to report encouraging patients to look for information, and to report having enough time in visits. Conclusion Physicians tend to perceive themselves as practicing their preferred role in clinical decision-making. The direction of the association cannot be inferred from these data; however, we suggest that interventions aimed at promoting shared decision-making need to target physicians as well as patients.

Abstract Background Clustering is a key step in the analysis of gene expression data, and in fact, many classical clustering algorithms are used, or more innovative ones have been designed and validated for the task. Despite the widespread use of artificial intelligence techniques in bioinformatics and, more generally, data analysis, there are very few clustering algorithms based on the genetic paradigm, yet that paradigm has great potential in finding good heuristic solutions to a difficult optimization problem such as clustering. Results GenClust is a new genetic algorithm for clustering gene expression data. It has two key features: (a) a novel coding of the search space that is simple, compact and easy to update; (b) it can be used naturally in conjunction with data driven internal validation methods. We have experimented with the FOM methodology, specifically conceived for validating clusters of gene expression data. The validity of GenClust has been assessed experimentally on real data sets, both with the use of validation measures and in comparison with other algorithms, i.e., Average Link, Cast, Click and K-means. Conclusion Experiments show that none of the algorithms we have used is markedly superior to the others across data sets and validation measures; i.e., in many cases the observed differences between the worst and best performing algorithm may be statistically insignificant and they could be considered equivalent. However, there are cases in which an algorithm may be better than others and therefore worthwhile. In particular, experiments for GenClust show that, although simple in its data representation, it converges very rapidly to a local optimum and that its ability to identify meaningful clusters is comparable, and sometimes superior, to that of more sophisticated algorithms. In addition, it is well suited for use in conjunction with data driven internal validation measures and, in particular, the FOM methodology.

Examinando a base conceitual da obra freudiana sobre a interpretação-sonho (Traumdeutung), o trabalho procura caracterizar alguns elementos para uma metapsicologia da interpretação psicanalítica. Conclui que da mesma maneira que o sonho, a interpretação aponta para as vicissitudes do manejo da angústia, no sentido de facilitar as vias de expressão e mobilidade do desejo.

Background: Influenza is responsible for more than 5 million severe cases and 290,000 to 650,000 deaths every year worldwide. Developing countries account for 99% of influenza deaths in children under 5 years of age. This paper aimed to determine the dynamics of influenza viruses in African transmission areas to identify regional seasonality for appropriate decision-making and the development of regional preparedness and response strategies., Methods: We used data from the WHO FluMart website collected by National Influenza Centers for seven transmission periods (2013-2019). We calculated weekly proportions of positive influenza cases and determined transmission trends in African countries to determine the seasonality., Results: From 2013 to 2019, influenza A(H1N1)pdm2009, A(H3N2), and A(H5N1) viruses, as well as influenza B Victoria and Yamagata lineages, circulated in African regions. Influenza A(H1N1)pdm2009 and A(H3N2) highly circulated in northern and southern Africa regions. Influenza activity followed annual and regional variations. In the tropical zone, from eastern to western via the middle regions, influenza activities were marked by the predominance of influenza A subtypes despite the circulation of B lineages. One season was identified for both the southern and northern regions of Africa. In the eastern zone, four influenza seasons were differentiated, and three were differentiated in the western zone., Conclusion: Circulation dynamics determined five intense influenza activity zones in Africa. In the tropics, influenza virus circulation waves move from the east to the west, while alternative seasons have been identified in northern and southern temperate zones. Health authorities from countries with the same transmission zone, even in the absence of local data based on an established surveillance system, should implement concerted preparedness and control activities, such as vaccination., (© 2022. The Author(s).)

Introduction: Drinking water and sanitation are two factors of inter-linked inextricably public health especially in the city of Nouakchott where the low availability of these services leads to a multitude of use and hygiene practices involving a complex socio-ecological system with an increased risk of waterborne diseases transmission (diarrhea, cholera, etc.)., Methods: Thus, this contribution analyzes the impact of socio-ecological system on the development of diarrheal diseases by using socio-environmental and epidemiological data from various sources (national surveys and registries consultation)., Results: Overall, the results show that only 25.6% of households have access to drinking water sources while 69.8% of the populations dispose improved latrines. Hence, the weakness in environmental sanitation conditions explains the level of diarrheal morbidity averring 12.8% at the urban level, with an unequal spatial distribution showing less affected communes such as Tevragh Zeina (9.1%) and municipalities more affected like Sebkha (19.1%). The distribution according to the age categories shows that children under 5 years are the most affected with 51.7% followed by people aged over 14 with 34.2%. The correlation analysis between socio-economic, environmental and epidemiological variables reveals a number of significant associations: untreated water consumption and diarrhea (R = 0.429); collection of wastewater and occurrence of diarrhea ; existence of improved latrine and reduction of diarrheal risk (R = 0.402)., Discussion: Therefore, exposure to diarrheal diseases through the prism of water and sanitation is a real public health problem that requires a systemic and integrated approach to improving environmental health.

Access to sufficient quantities of safe drinking water is a human right. Moreover, access to clean water is of public health relevance, particularly in semi-arid and Sahelian cities due to the risks of water contamination and transmission of water-borne diseases. We conducted a study in Nouakchott, the capital of Mauritania, to deepen the understanding of diarrhoeal incidence in space and time. We used an integrated geographical approach, combining socio-environmental, microbiological and epidemiological data from various sources, including spatially explicit surveys, laboratory analysis of water samples and reported diarrhoeal episodes. A geospatial technique was applied to determine the environmental and microbiological risk factors that govern diarrhoeal transmission. Statistical and cartographic analyses revealed concentration of unimproved sources of drinking water in the most densely populated areas of the city, coupled with a daily water allocation below the recommended standard of 20 l per person. Bacteriological analysis indicated that 93% of the non-piped water sources supplied at water points were contaminated with 10-80 coliform bacteria per 100 ml. Diarrhoea was the second most important disease reported at health centres, accounting for 12.8% of health care service consultations on average. Diarrhoeal episodes were concentrated in municipalities with the largest number of contaminated water sources. Environmental factors (e.g. lack of improved water sources) and bacteriological aspects (e.g. water contamination with coliform bacteria) are the main drivers explaining the spatio-temporal distribution of diarrhoea. We conclude that integrating environmental, microbiological and epidemiological variables with statistical regression models facilitates risk profiling of diarrhoeal diseases. Modes of water supply and water contamination were the main drivers of diarrhoea in this semi-arid urban context of Nouakchott, and hence require a strategy to improve water quality at the various levels of the supply chain.

Background: In Mauritania, some authors have described a possible high prevalence of hepatitis delta virus (HDV) infection in the 1990s in studies of small-size samples., Objectives: The aims of our study were to assess the prevalence of HDV in HBsAg positive blood donors in Mauritania, to identify the main risk factors for HDV transmission and to analyze genetic diversity of HDV strains., Study Design: From October 2008 to December 2009, 11,100 consecutive blood donors were considered in this study. Among them, 1700 (15.3%) were HBsAg positive and 455 accepted to participate in this study. Demographic, epidemiological, ethnical, clinical and biological data were recorded. HDV screening, i.e., antibodies (HDVAb) and RNA (HDV-RNA) detection, was performed for all of them as well as HDV and HBV genotyping., Results: Ninety/455 (19.78%) donors were HDVAb positive and HDV-RNA was detectable in 56 (62.2%) of them. HDV infection was significantly associated with older age, number of marriages, military profession, residence in the desert and a history of hospitalization. The HDV genotypes of the circulating strains were HDV-1 (89.3%) and HDV-5 (10.7%)., Conclusion: HDV is highly endemic in Mauritanian blood donors indicating that a high number of them will develop chronic hepatitis, cirrhosis or hepatocellular carcinoma. Associated risk factors support nosocomial transmission of HDV. These data underline the need to reinforce HBV vaccination in newborns and in blood donors without HBV markers, together with screening for HDV in HBV-infected individuals., (Copyright © 2012 Elsevier B.V. All rights reserved.)

This work presents the results of the behavioural and serologic survey on HIV/AIDS conducted from December 2007 to December 2008 among the group of STD (sexually transmitted disease) patients, supposed to be at HIV infection risk. In Mauritania, the last survey of HIV seroprevalence among the STD patients goes up to the year 1995 (the prevalence was estimated then to be 0.9%). The goal was to determine the seroprevalence of HIV and syphilis and to gather information on the knowledge, the sexual behaviours on a risk concerning the HIV/AIDS, and the sexually transmitted disease among these patients. The census has been made on over 224 STD patients during the period of the study, without predominance of sex and with a majority of young adults. The prevalence for HIV is 9% and for the syphilis it is 10%. Actually, the condom is widely underused by this group, even in occasional intercourse. The STD patients are a group of risk towards HIV, because of their risk behaviours and low level of knowledge.

In October 2003, 9 human cases of hemorrhagic fever were reported in 3 provinces of Mauritania, West Africa. Test results showed acute Rift Valley fever virus (RVFV) infection, and a field investigation found recent circulation of RVFV with a prevalence rate of 25.5% (25/98) and 4 deaths among the 25 laboratory-confirmed case-patients. Immunoglobulin M against RVFV was found in 46% (25/54) of domestic animals. RVFV was also isolated from the mosquito species Culex poicilipes. Genetic comparison of virion segments indicated little variation among the strains isolated. However, phylogenetic studies clearly demonstrated that these strains belonged to the East-Central African lineage for all segments. To our knowledge, this is the first time viruses of this lineage have been observed in an outbreak in West Africa. Whether these strains were introduced or are endemic in West Africa remains to be determined.