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Virological and epidemiological features of hepatitis delta infection among blood donors in Nouakchott, Mauritania.
- Source :
-
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [J Clin Virol] 2012 Sep; Vol. 55 (1), pp. 12-6. Date of Electronic Publication: 2012 Jun 14. - Publication Year :
- 2012
-
Abstract
- Background: In Mauritania, some authors have described a possible high prevalence of hepatitis delta virus (HDV) infection in the 1990s in studies of small-size samples.<br />Objectives: The aims of our study were to assess the prevalence of HDV in HBsAg positive blood donors in Mauritania, to identify the main risk factors for HDV transmission and to analyze genetic diversity of HDV strains.<br />Study Design: From October 2008 to December 2009, 11,100 consecutive blood donors were considered in this study. Among them, 1700 (15.3%) were HBsAg positive and 455 accepted to participate in this study. Demographic, epidemiological, ethnical, clinical and biological data were recorded. HDV screening, i.e., antibodies (HDVAb) and RNA (HDV-RNA) detection, was performed for all of them as well as HDV and HBV genotyping.<br />Results: Ninety/455 (19.78%) donors were HDVAb positive and HDV-RNA was detectable in 56 (62.2%) of them. HDV infection was significantly associated with older age, number of marriages, military profession, residence in the desert and a history of hospitalization. The HDV genotypes of the circulating strains were HDV-1 (89.3%) and HDV-5 (10.7%).<br />Conclusion: HDV is highly endemic in Mauritanian blood donors indicating that a high number of them will develop chronic hepatitis, cirrhosis or hepatocellular carcinoma. Associated risk factors support nosocomial transmission of HDV. These data underline the need to reinforce HBV vaccination in newborns and in blood donors without HBV markers, together with screening for HDV in HBV-infected individuals.<br /> (Copyright © 2012 Elsevier B.V. All rights reserved.)
- Subjects :
- Adolescent
Adult
Carrier State epidemiology
Carrier State virology
Female
Hepatitis Antibodies blood
Hepatitis B epidemiology
Hepatitis B virology
Hepatitis B Surface Antigens blood
Hepatitis D blood
Hepatitis Delta Virus genetics
Humans
Male
Mauritania epidemiology
Multivariate Analysis
Phylogeny
Risk Factors
Blood Donors statistics & numerical data
Hepatitis D epidemiology
Hepatitis D virology
Hepatitis Delta Virus isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1873-5967
- Volume :
- 55
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
- Publication Type :
- Academic Journal
- Accession number :
- 22704272
- Full Text :
- https://doi.org/10.1016/j.jcv.2012.05.011