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51. First-line Palliative Chemotherapy for Colorectal Cancer: a Population-based Analysis of Delivery and Outcomes in a Single-payer Health System

Author: Wilson, B.E., primary, Booth, C.M., additional, Patel, S., additional, Berry, S., additional, Kong, W., additional, and Merchant, S.J., additional
Published: 2023
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52. Tumor-Associated CD163+ M2 Macrophage Infiltration is Highly Associated with PD-L1 Expression in Cervical Cancer

Author: Guo F, Feng Y, Zhao G, Zhang R, Cheng Z, Kong W, Wu H, Xu B, Lv X, and Ma X
Subjects: cervical cancer, programmed death ligand 1, macrophages, tumor microenvironment, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Fan Guo,1,2,* Yang-chun Feng,1,2,* Gang Zhao,3 Ran Zhang,4 Zhen-zhen Cheng,1 Wei-na Kong,1,2 Hui-li Wu,1 Bin Xu,1 Xiang Lv,1 Xiu-min Ma1,2 1State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Laboratory Center, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi 830011, People’s Republic of China; 2The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, People’s Republic of China; 3Department of Blood Transfusion, Affiliated Traditional Chinese Medicine Hospital of Xinjiang Medical University, Urumqi 830000, People’s Republic of China; 4Clinical Pathology Center, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi 830000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiu-min MaState Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia Clinical Laboratory Center, Tumor Hospital Affiliated to Xinjiang Medical University, No. 789 Suzhou Road, Urumqi 830011, People’s Republic of ChinaEmail maxiumin1210@sohu.comBackground: Programmed death-ligand 1 (PD-L1) is a negative costimulatory molecule, and its main function is widely considered to be in the regulation of T cells. Tumor-associated macrophages (TAMs) are an important part of the tumor microenvironment, and they also play an important role in immunosuppression. However, the relationship between the expression of PD-L1 and TAMs in cervical carcinoma (CC) remains unclear. We detected the expression of PD-L1 and TAMs in tumor tissue to study the correlation between them.Methods: Immunohistochemical staining of PD-L1, CD68 (pan-macrophage), and CD163 (M2-like macrophage) was performed in 120 cases of cervical squamous cell carcinoma. Logistic regression analysis was used to evaluate the predictors related to positive PD-L1 expression. We also apply the Kaplan–Meier method to study the recurrence-free and overall survival rate of CC patients.Results: The increase in PD-L1 expression in tumor cells (TC) was significantly correlated with the increase in CD163 density (r=0.8550, p< 0.0001), while PD-L1 in the stroma was also significantly associated with the intratumoral density of CD68- or CD163-positive cells (CD68 p< 0.0001; CD163 p=0.0009). The mean infiltration rates of CD68- and CD163-positive cells in PD-L1-positive TC were significantly higher than in PD-L1-negative TC (CD68 p=0.0095; CD163 p< 0.0001). In multivariate logistic regression analyses, only the density of CD163-positive cells was correlated with the expression of PD-L1 in TC cells (OR 1.52; p=0.032). In prognostic analysis, PD-L1 more than 10% was significantly correlated with short RFS (HR=2.66; p=0.028). For CD163+ macrophage evaluation, the density above the median was also significantly correlated with RFS (HR=2.48; p=0.021).Conclusion: CD163+ M2-like macrophage infiltration is highly associated with PD-L1 expression in CC, suggesting that macrophage infiltration can serve as a potential therapeutic target.Keywords: cervical cancer, programmed death-ligand 1, macrophages, tumor microenvironment
Published: 2020

53. Socioeconomic variations determine the clinical presentation, aetiology, and outcome of infective endocarditis: a prospective cohort study from the ESC-EORP EURO-ENDO (European Infective Endocarditis) registry

Author: Sengupta, S, Prendergast, B, Laroche, C, Furnaz, S, Ronderos, R, Almaghraby, A, Asch, F, Blechova, K, Zaky, H, Strahilevitz, J, Dworakowski, R, Miyasaka, Y, Sebag, I, Izumi, C, Axler, O, Jamiel, A, Philip, M, Vieira, M, Lancellotti, P, Habib, G, Gale, C, Beleslin, B, Budaj, A, Chioncel, O, Dagres, N, Danchin, N, Emberson, J, Erlinge, D, Glikson, M, Gray, A, Kayikcioglu, M, Maggioni, A, Nagy, V, Nedoshivin, A, Petronio, A, Roos-Hesselink, J, Wallentin, L, Zeymer, U, Cosyns, B, Donal, E, Erba, P, Iung, B, Popescu, B, Tornos, P, Andarala, M, Berle, C, Brunel-Lebecq, A, Fiorucci, E, Missiamenou, V, Taylor, C, Ali Tatar-Chentir, N, Al-Mallah, M, Astrom Aneq, M, Athanassopoulos, G, Badano, L, Benyoussef, S, Calderon Aranda, E, Cardim, N, Chan, K, Cruz, I, Edvardsen, T, Goliasch, G, Hagendorff, A, Hristova, K, Kamp, O, Kang, D, Kong, W, Matskeplishvili, S, Meshaal, M, Mirocevic, M, Neskovic, A, Pazdernik, M, Plonska-Gosciniak, E, Raissouni, M, Sade, L, Sadeghpour, A, Sambola, A, Separovic-Hanzevacki, J, Takeuchi, M, Tucay, E, Tude Rodrigues, A, Varga, A, Vaskelyte, J, Yamagata, K, Yiangou, K, Granada, I, Mahia, M, Ressi, S, Na-Cinovich, F, Iribarren, A, Fernandez Oses, P, Avegliano, G, Filipini, E, Obregon, R, Bangher, M, Dho, J, Cartasegna, L, Plastino, M, Novas, V, Shigel, C, Reyes, G, De Santos, M, Gastaldello, N, Granillo Fernandez, M, Potito, M, Streit-Enberger, G, Velazco, P, Casabe, J, Cortes, C, Guevara, E, Salmo, F, Seijo, M, Weidinger, F, Heger, M, Brooks, R, Stollberger, C, Ho, C, Perschy, L, Puskas, L, Binder, C, Rosenhek, R, Schneider, M, Winter, M, Hoffer, E, Melis-Sopoulou, M, Lecoq, E, Legrand, D, Jacquet, S, Massoz, M, Pierard, L, Marchetta, S, Dulgheru, R, D'Emal, C, Oury, C, Droog-Mans, S, Kerkhove, D, Plein, D, Soens, L, Weytjens, C, Motoc, A, Roosens, B, Lemoine, I, Rodrigus, I, Paelinck, B, Am-Sel, B, Unger, P, Konopnicki, D, Beauloye, C, Pasquet, A, Vanoverschelde, J, Pierard, S, Vancraeynest, D, Sinnaeve, F, Andrade, J, Staszko, K, Dos Santos Monteiro, R, Miglioranza, M, Shuha, D, Alcantara, M, Cravo, V, Fazzio, L, Felix, A, Iso, M, Musa, C, Siciliano, A, Villaca Filho, F, Rodrigues, A, Vilela, F, Braga, J, Silva, R, Rodrigues, D, Silva, L, Morhy, S, Fischer, C, Afonso, T, Abreu, J, Falcao, S, Moises, V, Gou-Vea, A, Mancuso, F, Souza, A, Silva, C, Joao, G, Abboud, C, Bellio de Mattos Barretto, R, Ramos, A, Arnoni, R, Assef, J, Della Togna, D, Le Bihan, D, Miglioli, L, Romero Oliveira, A, Tadeu Magro Kroll, R, Cortez, D, Gelape, C, Peirira Nunes, M, De Abreu Ferrari, T, Hay, K, Le, V, Page, M, Poulin, F, Sauve, C, Serri, K, Mercure, C, Beaudoin, J, Pibarot, P, Rudski, L, Ricafort, G, Barsic, B, Krajinovic, V, Vargovic, M, Lovric, D, Reskovic-Luksic, V, Vincelj, J, Jaksic Jurinjak, S, Yiannikourides, V, Ioannides, M, Pofaides, C, Masoura, V, Pudich, J, Linhart, A, Siranec, M, Marek, J, Kamenik, M, Pelouch, R, Coufal, Z, Mikulica, M, Griva, M, Jancova, E, Mikulcova, M, Taborsky, M, Precek, J, Jecmenova, M, Latal, J, Widimsky, J, Butta, T, Machacek, S, Vancata, R, Spinar, J, Holicka, M, Pow Chon Long, F, Anzules, N, Bajana Carpio, A, Largacha, G, Penaherrera, E, Moreira, D, Mahfouz, E, Elsafty, E, Soliman, A, Zayed, Y, Aboulenein, J, Abdel-Hay, M, Abdelnaby, M, Ahmed, M, Hammad, B, Saleh, Y, Zahran, H, El-Gebaly, O, Saad, A, Ali, M, Zeid, A, El Sharkawy, R, Al Kholy, A, Doss, R, Osama, D, Rizk, H, Elmogy, A, Mishriky, M, Assayag, P, El Hatimi, S, Hubert, S, Casalta, J, Gouriet, F, Arregle, F, Cammilleri, S, Tessonnier, L, Riberi, A, Botelho-Nevers, E, Gagneux-Brunon, A, Pierrard, R, Tulane, C, Campisi, S, Fuzellier, J, Detoc, M, Mehalla, T, Boutoille, D, Lecompte, A, Lefebvre, M, Pattier, S, Al Habash, O, Asseray-Madani, N, Biron, C, Brochard, J, Caillon, J, Cueff, C, Le Tourneau, T, Lecomte, R, Magali Michel, M, Orain, J, Delarue, S, Le Bras, M, Faucher, J, Aboyans, V, Bee-Harry, A, Durox, H, Lacoste, M, Magne, J, Mohty, D, David, A, Pradel, V, Sierra, V, Neykova, A, Bettayeb, B, Elkentaoui, S, Tzvetkov, B, Landry, G, Strady, C, Ainine, K, Baumard, S, Brasselet, C, Tassigny, C, Valente-Pires, V, Lefranc, M, Hoen, B, Lefevre, B, Curlier, E, Callier, C, Fourcade, N, Jobic, Y, Ansard, S, Le Berre, R, Le Ven, F, Pouliquen, M, Prat, G, Le Roux, P, Bouchart, F, Savoure, A, Alarcon, C, Chapuzet, C, Gueit, I, Tribouilloy, C, Bohbot, Y, Peugnet, F, Gun, M, Duval, X, Lescure, X, Ilic-Habensus, E, Sadoul, N, Selton-Suty, C, Alla, F, Goehringer, F, Huttin, O, Chevalier, E, Garcia, R, Le Marcis, V, Tattevin, P, Flecher, E, Revest, M, Chirouze, C, Bouiller, K, Hustache-Mathieu, L, Klopfenstein, T, Moreau, J, Fournier, D, Brunel, A, Lim, P, Oliver, L, Ternacle, J, Moussafeur, A, Chavanet, P, Piroth, L, Salmon-Rousseau, A, Buisson, M, Mahy, S, Martins, C, Go-Hier, S, Baumann, F, Lebras, S, Piper, C, Guckel, D, Borgermann, J, Horstkotte, D, Winkelmann, E, Brockmeier, B, Grey, D, Nick-Enig, G, Schueler, R, Ozturk, C, Stohr, E, Hamm, C, Walther, T, Brandt, R, Fruhauf, A, Hartung, C, Hellner, C, Wild, C, Becker, M, Hamada, S, Kaestner, W, Stangl, K, Knebel, F, Baldenhofer, G, Brecht, A, Dreger, H, Isner, C, Pfafflin, F, Stegemann, M, Zahn, R, Fraiture, B, Kilkowski, C, Karcher, A, Klinger, S, Tolksdorf, H, Tousoulis, D, Aggeli, C, Sideris, S, Venieri, E, Sarri, G, Tsiapras, D, Armenis, I, Koutsiari, A, Floros, G, Grassos, C, Dragasis, S, Rallidis, L, Varlamos, C, Michalis, L, Naka, K, Bechlioulis, A, Kotsia, A, Lakkas, L, Pappas, K, Papadopoulos, C, Kiokas, S, Lioni, A, Misailidou, S, Bar-Betseas, J, Bonou, M, Kapelios, C, Tomprou, I, Zerva, K, Manolis, A, Hamodraka, E, Athanasiou, D, Haralambidis, G, Samaras, H, Poulimenos, L, Nagy, A, Bartykowszki, A, Gara, E, Mungulmare, K, Kasliwal, R, Bansal, M, Ranjan, S, Bhan, A, Kyavar, M, Maleki, M, Noohi Bezanjani, F, Alizadehasl, A, Boudagh, S, Ghavidel, A, Morad-Nejad, P, Pasha, H, Ghadrdoost, B, Gilon, D, Wanounou, M, Israel, S, D'Agostino, C, Colonna, P, De Michele, L, Fumarola, F, Stante, M, Mar-Chionni, N, Scheggi, V, Alterini, B, Del Pace, S, Stefano, P, Sparano, C, Ruozi, N, Tenaglia, R, Muraru, D, Limbruno, U, Cresti, A, Baratta, P, Solari, M, Giannattasio, C, Moreo, A, De Chiara, B, Lopez Montero, B, Musca, F, Orcese, C, Panzeri, F, Spano, F, Russo, C, Alferi, O, De Bonis, M, Chiappetta, S, Del Forno, B, Ripa, M, Scarpellini, P, Tassan Din, C, Castiglioni, B, Pasci-Uta, R, Carletti, S, Ferrara, D, Guffanti, M, Iaci, G, Lapenna, E, Nisi, T, Oltolini, C, Busnardo, E, Pajoro, U, Agricola, E, Meneghin, R, Schiavi, D, Piscione, F, Citro, R, Benvenga, R, Greco, L, Soriente, L, Radano, I, Prota, C, Bellino, M, Di Vece, D, Santini, F, Salsano, A, Olivieri, G, Turrini, F, Messora, R, Tondi, S, Olaru, A, Agnoletto, V, Grassi, L, Leonardi, C, Sansoni, S, Del Ponte, S, Actis Dato, G, De Martino, A, Ohte, N, Kikuchi, S, Wakami, K, Aonuma, K, Seo, Y, Ishizu, T, Machino-Ohtsuka, T, Yamamoto, M, Iida, N, Nakajima, H, Nakagawa, Y, Amano, M, Miyake, M, Takahashi, K, Shiojima, I, Maeba, H, Suwa, Y, Taniguchi, N, Tsujimoto, S, Kitai, T, Ota, M, Yuda, S, Sasaki, S, Hagiwara, N, Yamazaki, K, Ashihara, K, Arai, K, Saitou, C, Saitou, S, Suzuki, G, Shibata, Y, Watanabe, N, Nishino, S, Ashikaga, K, Kuriyama, N, Mahara, K, Okubo, T, Fujimaki, H, Shi-Tan, H, Yamamoto, H, Abe, K, Terada, M, Takanashi, S, Sata, M, Yamada, H, Kusunose, K, Saijo, Y, Seno, H, Yuichiro, O, Onishi, T, Sera, F, Nakatani, S, Mizuno, H, Sengoku, K, Park, S, Eun Kyoung, K, Ga Yeon, L, Hwang, J, Jin-Oh, C, Sang-Chol, L, Sung-A, C, Jang, S, Heo, R, Lee, S, Song, J, Jung, E, Plisiene, J, Dambrauskaite, A, Gruodyte, G, Jonkaitiene, R, Mizariene, V, Atkocaityte, J, Zvirblyte, R, Sow, R, Codreanu, A, Staub, T, Michaux, C, De la Vega, E, Jacobs-Orazi, L, Mallia Azzopardi, C, Xuereb, R, Pis-Copo, T, Farrugia, J, Fenech, M, Pllaha, E, Vella, C, Borg, D, Casha, R, Grib, L, Raevschi, E, Gre-Jdieru, A, Kravcenco, D, Prisacari, E, Samohvalov, E, Samohvalov, S, Sceglova, N, Panfle, E, Cardaniuc, L, Corcea, V, Feodorovici, A, Gaina, V, Girbu, L, Jimbei, P, Balan, G, Cardaniuc, I, Benesco, I, Marian, V, Sumarga, N, Bozovic, B, Bulatovic, N, Lakovic, P, Music, L, Budde, R, Waha-Dat, A, Gamela, T, Meijers, T, Van Melle, J, Deursen, V, Crijns, H, Bekkers, S, Cheriex, E, Gilbers, M, Kietselaer, B, Knackstedt, C, Lorusso, R, Schalla, S, Streukens, S, Chamuleau, S, Cramer, M, Teske, A, Van der Spoel, T, Wind, A, Lokhorst, J, Liesbek, O, Van Heusden, H, Tanis, W, Van der Bilt, I, Vriend, J, De Lange-Van Bruggen, H, Karijodikoro, E, Riezebos, R, van Dongen, E, Schoep, J, Stolk, V, Offstad, J, Beitnes, J, Helle-Valle, T, Skulstad, H, Skardal, R, Qamar, N, Ahmed, B, Butt, M, Khanzada, M, Saghir, T, Wahid, A, Hryniewiecki, T, Szymanski, P, Marzec, K, Misztal-Ogonowska, M, Kosmala, W, Przewlocka-Kosmala, M, Rojek, A, Woznicka, K, Zachwyc, J, Lisowska, A, Kamin-Ska, M, Kasprzak, J, Kowalczyk, E, Strzecka, D, Wejner-Mik, P, Trabulo, M, Freitas, P, Ranchordas, S, Rodrigues, G, Pinto, P, Queiros, C, Azevedo, J, Marques, L, Seabra, D, Branco, L, Cruz, M, Galrinho, A, Moreira, R, Rio, P, Timoteo, A, Selas, M, Carmelo, V, Duque Neves, B, Pereira, H, Guerra, A, Marques, A, Pintassilgo, I, Tomescu, M, Trofenciuc, N, Andor, M, Bordejevic, A, Branea, H, Caruntu, F, Velcean, L, Mavrea, A, Onel, M, Parvanescu, T, Pop, D, Pop-Moldovan, A, Puticiu, M, Cirin, L, Citu, I, Cotoraci, C, Darabantiu, D, Farcas, R, Marincu, I, Ionac, A, Cozma, D, Mornos, C, Goanta, F, Popescu, I, Beyer, R, Mada, R, Rancea, R, Tomoaia, R, Rosianu, H, Stanescu, C, Kobalava, Z, Karaulova, J, Ko-Tova, E, Milto, A, Pisaryuk, A, Povalyaev, N, Sorokina, M, Alrahimi, J, Elshiekh, A, Ahmed, A, Attia, N, Putnikovic, B, Dimic, A, Ivanovic, B, Matic, S, Trifunovic, D, Petrovic, J, Kosevic, D, Stojanovic, I, Petrovic, I, Dabic, P, Milojevic, P, Srdanovic, I, Susak, S, Velicki, L, Vulin, A, Kovacevic, M, Redzek, A, Stefanovic, M, Yeo, T, Poh, K, Vi-Lacosta, I, Ferrera, C, Olmos, C, Abd El-Nasser, M, Calvo Iglesias, F, Bianco-Gonzalez, E, Bravo Amaro, M, Lopez-Rodriguez, E, Lugo Adan, J, Germinas, A, Pazos-Lopez, P, Pereira Loureiro, M, Perez, M, Raposeiras-Roubin, S, Rasheed Yas, S, Suarez-Varela, M, Vasallo Vidal, F, Garcia-Dorado, D, Fernandez-Hidalgo, N, Gonzalez-Alujas, T, Lozano, J, Maisterra, O, Pizzi, N, Rios, R, Bayes-Genis, A, Pedro Botet, L, Vallejo, N, Llibre, C, Mateu, L, Nunez, R, Quesada, D, Berastegui, E, Bosch Portell, D, Aboal Vinas, J, Albert Bertran, X, Brugada Tar-Radellas, R, Loma-Osorio Ricon, P, Tiron de Llano, C, Arnau, M, Bel, A, Blanes, M, Osa, A, Anguita, M, Carrasco, F, Castillo, J, Zamorano, J, Moya Mur, J, Alvaro, M, Fernandez-Golfin, C, Monteagudo, J, Navas Elorza, E, Farinas Alvarez, M, Aguero Balbin, J, Zarauza, J, Gutierrez-Diez, J, Arminanzas, C, Arnaiz de las Revillas, F, Arnaiz Garcia, A, Cobo Belaustegui, M, Fernandez Sampedro, M, Gutierrez Cuadra, M, Garcia Cuello, L, Gonzalez Rico, C, Rodriguez-Alvarez, R, Goikoetxea, J, Montejo, M, Miro, J, Almela, M, Ambrosioni, J, Moreno, A, Quintana, E, Sandoval, E, Tellez, A, Tolosana, J, Vidal, B, Falces, C, Fuster, D, Garcia-De-la-Maria, C, Hernandez-Meneses, M, Llopis, J, Marco, F, Ruiz-Zamora, I, Bardaji Ruiz, A, Sanz Girgas, E, Garcia-Pardo, G, Guillen Marzo, M, Rodriguez Oviedo, A, Villares Jimenez, A, Abid, L, Ham-Mami, R, Kammoun, S, Mourali, M, Mghaieth Zghal, F, Ben Hlima, M, Boudiche, S, Ouali, S, Zakhama, L, Antit, S, Slama, I, Gulel, O, Sahin, M, Karacaglar, E, Kucukoglu, S, Cetinarslan, O, Sinan, U, Canpolat, U, Mutlu, B, Atas, H, Dervishova, R, Ileri, C, Alhashmi, J, Tahir, J, Zarger, P, Baslib, F, Woldman, S, Menezes, L, Primus, C, Uppal, R, Bvekerwa, I, Chandrasekaran, B, Kopanska, A, Chambers, J, Hancock, J, Klein, J, Rajani, R, Ursi, M, Cannata, S, Fife, A, Breeze, J, Browne-Morgan, M, Gunning, M, Streather, S, Zemedkun, M, Alyavi, B, Uzokov, J, Sengupta S. P., Prendergast B., Laroche C., Furnaz S., Ronderos R., Almaghraby A., Asch F. M., Blechova K., Zaky H., Strahilevitz J., Dworakowski R., Miyasaka Y., Sebag I., Izumi C., Axler O., Jamiel A., Philip M., Vieira M. L. C., Lancellotti P., Habib G., Gale C. P., Beleslin B., Budaj A., Chioncel O., Dagres N., Danchin N., Emberson J., Erlinge D., Glikson M., Gray A., Kayikcioglu M., Maggioni A. P., Nagy V. K., Nedoshivin A., Petronio A. -S., Roos-Hesselink J., Wallentin L., Zeymer U., Cosyns B., Donal E., Erba P., Iung B., Popescu B. A., Tornos P., Andarala M., Berle C., Brunel-Lebecq A., Fiorucci E., Missiamenou V., Taylor C., Ali Tatar-Chentir N. N., Al-Mallah M., Astrom Aneq M., Athanassopoulos G., Badano L. P., Benyoussef S., Calderon Aranda E., Cardim N. M., Chan K. -L., Cruz I., Edvardsen T., Goliasch G., Hagendorff A., Hristova K., Kamp O., Kang D. -H., Kong W., Matskeplishvili S., Meshaal M., Mirocevic M., Neskovic A. N., Pazdernik M., Plonska-Gosciniak E., Raissouni M., Sade L. E., Sadeghpour A., Sambola A., Separovic-Hanzevacki J., Takeuchi M., Tucay E., Tude Rodrigues A. C., Varga A., Vaskelyte J., Yamagata K., Yiangou K., Granada I., Mahia M., Ressi S., Na-Cinovich F., Iribarren A., Fernandez Oses P., Avegliano G., Filipini E., Obregon R., Bangher M., Dho J., Cartasegna L., Plastino M. L., Novas V., Shigel C., Reyes G., De Santos M., Gastaldello N., Granillo Fernandez M., Potito M., Streit-Enberger G., Velazco P., Casabe J. H., Cortes C., Guevara E., Salmo F., Seijo M., Weidinger F., Heger M., Brooks R., Stollberger C., Ho C. -Y., Perschy L., Puskas L., Binder C., Rosenhek R., Schneider M., Winter M. -P., Hoffer E., Melis-Sopoulou M., Lecoq E., Legrand D., Jacquet S., Massoz M., Pierard L., Marchetta S., Dulgheru R., D'Emal C., Oury C., Droog-Mans S., Kerkhove D., Plein D., Soens L., Weytjens C., Motoc A., Roosens B., Lemoine I., Rodrigus I., Paelinck B., Am-Sel B., Unger P., Konopnicki D., Beauloye C., Pasquet A., Vanoverschelde J. L., Pierard S., Vancraeynest D., Sinnaeve F., Andrade J. L., Staszko K., Dos Santos Monteiro R., Miglioranza M. H., Shuha D. L., Alcantara M., Cravo V., Fazzio L., Felix A., Iso M., Musa C., Siciliano A. P., Villaca Filho F., Rodrigues A., Vilela F., Braga J., Silva R., Rodrigues D., Silva L., Morhy S., Fischer C., Afonso T., Abreu J., Falcao S. N., Moises V. A., Gou-Vea A., Mancuso F. J., Souza A. C., Silva C. Y., Joao G., Abboud C. S., Bellio de Mattos Barretto R., Ramos A., Arnoni R., Assef J. E., Della Togna D. J., Le Bihan D., Miglioli L., Romero Oliveira A. P., Tadeu Magro Kroll R., Cortez D., Gelape C. L., Peirira Nunes M. D. C., De Abreu Ferrari T. C., Hay K., Le V., Page M., Poulin F., Sauve C., Serri K., Mercure C., Beaudoin J., Pibarot P., Rudski L. G., Ricafort G., Barsic B., Krajinovic V., Vargovic M., Lovric D., Reskovic-Luksic V., Vincelj J., Jaksic Jurinjak S., Yiannikourides V., Ioannides M., Pofaides C., Masoura V., Pudich J., Linhart A., Siranec M., Marek J., Kamenik M., Pelouch R., Coufal Z., Mikulica M., Griva M., Jancova E., Mikulcova M., Taborsky M., Precek J., Jecmenova M., Latal J., Widimsky J., Butta T., Machacek S., Vancata R., Spinar J., Holicka M., Pow Chon Long F., Anzules N., Bajana Carpio A., Largacha G., Penaherrera E., Moreira D., Mahfouz E., Elsafty E., Soliman A., Zayed Y., Aboulenein J., Abdel-Hay M., Abdelnaby M., Ahmed M., Hammad B., Saleh Y., Zahran H., El-Gebaly O., Saad A., Ali M., Zeid A., El Sharkawy R., Al Kholy A., Doss R., Osama D., Rizk H., Elmogy A., Mishriky M., Assayag P., El Hatimi S., Hubert S., Casalta J. -P., Gouriet F., Arregle F., Cammilleri S., Tessonnier L., Riberi A., Botelho-Nevers E., Gagneux-Brunon A., Pierrard R., Tulane C., Campisi S., Fuzellier J. -F., Detoc M., Mehalla T., Boutoille D., Lecompte A. S., Lefebvre M., Pattier S., Al Habash O., Asseray-Madani N., Biron C., Brochard J., Caillon J., Cueff C., Le Tourneau T., Lecomte R., Magali Michel M. M., Orain J., Delarue S., Le Bras M., Faucher J. -F., Aboyans V., Bee-Harry A., Durox H., Lacoste M., Magne J., Mohty D., David A., Pradel V., Sierra V., Neykova A., Bettayeb B., Elkentaoui S., Tzvetkov B., Landry G., Strady C., Ainine K., Baumard S., Brasselet C., Tassigny C., Valente-Pires V., Lefranc M., Hoen B., Lefevre B., Curlier E., Callier C., Fourcade N., Jobic Y., Ansard S., Le Berre R., Le Ven F., Pouliquen M. -C., Prat G., Le Roux P., Bouchart F., Savoure A., Alarcon C., Chapuzet C., Gueit I., Tribouilloy C., Bohbot Y., Peugnet F., Gun M., Duval X., Lescure X., Ilic-Habensus E., Sadoul N., Selton-Suty C., Alla F., Goehringer F., Huttin O., Chevalier E., Garcia R., Le Marcis V., Tattevin P., Flecher E., Revest M., Chirouze C., Bouiller K., Hustache-Mathieu L., Klopfenstein T., Moreau J., Fournier D., Brunel A. -S., Lim P., Oliver L., Ternacle J., Moussafeur A., Chavanet P., Piroth L., Salmon-Rousseau A., Buisson M., Mahy S., Martins C., Go-Hier S., Baumann F., Lebras S., Piper C., Guckel D., Borgermann J., Horstkotte D., Winkelmann E., Brockmeier B., Grey D., Nick-Enig G., Schueler R., Ozturk C., Stohr E., Hamm C., Walther T., Brandt R., Fruhauf A. -C., Hartung C. T., Hellner C., Wild C., Becker M., Hamada S., Kaestner W., Stangl K., Knebel F., Baldenhofer G., Brecht A., Dreger H., Isner C., Pfafflin F., Stegemann M., Zahn R., Fraiture B., Kilkowski C., Karcher A. -K., Klinger S., Tolksdorf H., Tousoulis D., Aggeli C., Sideris S., Venieri E., Sarri G., Tsiapras D., Armenis I., Koutsiari A., Floros G., Grassos C., Dragasis S., Rallidis L., Varlamos C., Michalis L., Naka K., Bechlioulis A., Kotsia A., Lakkas L., Pappas K., Papadopoulos C., Kiokas S., Lioni A., Misailidou S., Bar-Betseas J., Bonou M., Kapelios C., Tomprou I., Zerva K., Manolis A., Hamodraka E., Athanasiou D., Haralambidis G., Samaras H., Poulimenos L., Nagy A., Bartykowszki A., Gara E., Mungulmare K., Kasliwal R., Bansal M., Ranjan S., Bhan A., Kyavar M., Maleki M., Noohi Bezanjani F., Alizadehasl A., Boudagh S., Ghavidel A., Morad-Nejad P., Pasha H. R., Ghadrdoost B., Gilon D., Wanounou M., Israel S., d'Agostino C., Colonna P., De Michele L., Fumarola F., Stante M., Mar-Chionni N., Scheggi V., Alterini B., Del Pace S., Stefano P., Sparano C., Ruozi N., Tenaglia R., Muraru D., Limbruno U., Cresti A., Baratta P., Solari M., Giannattasio C., Moreo A., De Chiara B., Lopez Montero B., Musca F., Orcese C. A., Panzeri F., Spano F., Russo C. F., Alferi O., De Bonis M., Chiappetta S., Del Forno B., Ripa M., Scarpellini P., Tassan Din C., Castiglioni B., Pasci-Uta R., Carletti S., Ferrara D., Guffanti M., Iaci G., Lapenna E., Nisi T., Oltolini C., Busnardo E., Pajoro U., Agricola E., Meneghin R., Schiavi D., Piscione F., Citro R., Benvenga R. M., Greco L., Soriente L., Radano I., Prota C., Bellino M., Di Vece D., Santini F., Salsano A., Olivieri G. M., Turrini F., Messora R., Tondi S., Olaru A., Agnoletto V., Grassi L., Leonardi C., Sansoni S., Del Ponte S., Actis Dato G. M., De Martino A., Ohte N., Kikuchi S., Wakami K., Aonuma K., Seo Y., Ishizu T., Machino-Ohtsuka T., Yamamoto M., Iida N., Nakajima H., Nakagawa Y., Amano M., Miyake M., Takahashi K., Shiojima I., Maeba H., Suwa Y., Taniguchi N., Tsujimoto S., Kitai T., Ota M., Yuda S., Sasaki S., Hagiwara N., Yamazaki K., Ashihara K., Arai K., Saitou C., Saitou S., Suzuki G., Shibata Y., Watanabe N., Nishino S., Ashikaga K., Kuriyama N., Mahara K., Okubo T., Fujimaki H., Shi-Tan H., Yamamoto H., Abe K., Terada M., Takanashi S., Sata M., Yamada H., Kusunose K., Saijo Y., Seno H., Yuichiro O., Onishi T., Sera F., Nakatani S., Mizuno H., Sengoku K., Park S. W., Eun Kyoung K., Ga Yeon L., Hwang J. -W., Jin-Oh C., Park S. -J., Sang-Chol L., Sung-A C., Jang S. Y., Heo R., Lee S., Song J. -M., Jung E., Plisiene J., Dambrauskaite A., Gruodyte G., Jonkaitiene R., Mizariene V., Atkocaityte J., Zvirblyte R., Sow R., Codreanu A., Staub T., Michaux C., De la Vega E. C. L., Jacobs-Orazi L., Mallia Azzopardi C., Xuereb R. G., Pis-Copo T., Farrugia J., Fenech M., Pllaha E., Vella C., Borg D., Casha R., Grib L., Raevschi E., Gre-Jdieru A., Kravcenco D., Prisacari E., Samohvalov E., Samohvalov S., Sceglova N., Panfle E., Cardaniuc L., Corcea V., Feodorovici A., Gaina V., Girbu L., Jimbei P., Balan G., Cardaniuc I., Benesco I., Marian V., Sumarga N., Bozovic B., Bulatovic N., Lakovic P., Music L., Budde R., Waha-Dat A., Gamela T., Meijers T., Van Melle J. P., Deursen V. M., Crijns H. J., Bekkers S. C., Cheriex E. C., Gilbers M., Kietselaer B. L., Knackstedt C., Lorusso R., Schalla S., Streukens S. A., Chamuleau S., Cramer M. -J., Teske A., Van der Spoel T., Wind A., Lokhorst J., Liesbek O., Van Heusden H., Tanis W., Van der Bilt I., Vriend J., De Lange-Van Bruggen H., Karijodikoro E., Riezebos R., van Dongen E., Schoep J., Stolk V., Offstad J. T., Beitnes J. O., Helle-Valle T., Skulstad H., Skardal R., Qamar N., Ahmed B., Butt M. H., Khanzada M. F., Saghir T., Wahid A., Hryniewiecki T., Szymanski P., Marzec K., Misztal-Ogonowska M., Kosmala W., Przewlocka-Kosmala M., Rojek A., Woznicka K., Zachwyc J., Lisowska A., Kamin-Ska M., Kasprzak J. D., Kowalczyk E., Strzecka D. F., Wejner-Mik P., Trabulo M., Freitas P., Ranchordas S., Rodrigues G., Pinto P., Queiros C., Azevedo J., Marques L., Seabra D., Branco L., Cruz M., Galrinho A., Moreira R., Rio P., Timoteo A. T., Selas M., Carmelo V., Duque Neves B., Pereira H., Guerra A., Marques A., Pintassilgo I., Tomescu M. C., Trofenciuc N. -M., Andor M., Bordejevic A., Branea H. S., Caruntu F., Velcean L. A., Mavrea A., Onel M. F., Parvanescu T., Pop D., Pop-Moldovan A. L., Puticiu M. I., Cirin L., Citu I. M., Cotoraci C. 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T., Raposeiras-Roubin S., Rasheed Yas S., Suarez-Varela M. -M., Vasallo Vidal F., Garcia-Dorado D., Fernandez-Hidalgo N., Gonzalez-Alujas T., Lozano J., Maisterra O., Pizzi N., Rios R., Bayes-Genis A., Pedro Botet L., Vallejo N., Llibre C., Mateu L., Nunez R., Quesada D., Berastegui E., Bosch Portell D., Aboal Vinas J., Albert Bertran X., Brugada Tar-Radellas R., Loma-Osorio Ricon P., Tiron de Llano C., Arnau M. A., Bel A., Blanes M., Osa A., Anguita M., Carrasco F., Castillo J. C., Zamorano J. L., Moya Mur J. L., Alvaro M., Fernandez-Golfin C., Monteagudo J. M., Navas Elorza E., Farinas Alvarez M. C., Aguero Balbin J., Zarauza J., Gutierrez-Diez J. F., Arminanzas C., Arnaiz de las Revillas F., Arnaiz Garcia A., Cobo Belaustegui M., Fernandez Sampedro M., Gutierrez Cuadra M., Garcia Cuello L., Gonzalez Rico C., Rodriguez-Alvarez R., Goikoetxea J., Montejo M., Miro J. M., Almela M., Ambrosioni J., Moreno A., Quintana E., Sandoval E., Tellez A., Tolosana J. M., Vidal B., Falces C., Fuster D., Garcia-De-la-Maria C., Hernandez-Meneses M., Llopis J., Marco F., Ruiz-Zamora I., Bardaji Ruiz A., Sanz Girgas E., Garcia-Pardo G., Guillen Marzo M., Rodriguez Oviedo A., Villares Jimenez A., Abid L., Ham-Mami R., Kammoun S., Mourali M. S., Mghaieth Zghal F., Ben Hlima M., Boudiche S., Ouali S., Zakhama L., Antit S., Slama I., Gulel O., Sahin M., Karacaglar E., Kucukoglu S., Cetinarslan O., Sinan U. Y., Canpolat U., Mutlu B., Atas H., Dervishova R., Ileri C., Alhashmi J., Tahir J., Zarger P., Baslib F., Woldman S., Menezes L., Primus C., Uppal R., Bvekerwa I., Chandrasekaran B., Kopanska A., Chambers J., Hancock J., Klein J., Rajani R., Ursi M. 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A., Darabantiu D., Farcas R., Marincu I., Ionac A., Cozma D., Mornos C., Goanta F., Popescu I., Beyer R., Mada R., Rancea R., Tomoaia R., Rosianu H., Stanescu C., Kobalava Z., Karaulova J., Ko-Tova E., Milto A., Pisaryuk A., Povalyaev N., Sorokina M., Alrahimi J., Elshiekh A., Ahmed A., Attia N., Putnikovic B., Dimic A., Ivanovic B., Matic S., Trifunovic D., Petrovic J., Kosevic D., Stojanovic I., Petrovic I., Dabic P., Milojevic P., Srdanovic I., Susak S., Velicki L., Vulin A., Kovacevic M., Redzek A., Stefanovic M., Yeo T. C., Kong W. K. F., Poh K. K., Vi-Lacosta I., Ferrera C., Olmos C., Abd El-Nasser M., Calvo Iglesias F., Bianco-Gonzalez E., Bravo Amaro M., Lopez-Rodriguez E., Lugo Adan J., Germinas A. N., Pazos-Lopez P., Pereira Loureiro M., Perez M. T., Raposeiras-Roubin S., Rasheed Yas S., Suarez-Varela M. -M., Vasallo Vidal F., Garcia-Dorado D., Fernandez-Hidalgo N., Gonzalez-Alujas T., Lozano J., Maisterra O., Pizzi N., Rios R., Bayes-Genis A., Pedro Botet L., Vallejo N., Llibre C., Mateu L., Nunez R., Quesada D., Berastegui E., Bosch Portell D., Aboal Vinas J., Albert Bertran X., Brugada Tar-Radellas R., Loma-Osorio Ricon P., Tiron de Llano C., Arnau M. A., Bel A., Blanes M., Osa A., Anguita M., Carrasco F., Castillo J. C., Zamorano J. L., Moya Mur J. L., Alvaro M., Fernandez-Golfin C., Monteagudo J. M., Navas Elorza E., Farinas Alvarez M. C., Aguero Balbin J., Zarauza J., Gutierrez-Diez J. F., Arminanzas C., Arnaiz de las Revillas F., Arnaiz Garcia A., Cobo Belaustegui M., Fernandez Sampedro M., Gutierrez Cuadra M., Garcia Cuello L., Gonzalez Rico C., Rodriguez-Alvarez R., Goikoetxea J., Montejo M., Miro J. M., Almela M., Ambrosioni J., Moreno A., Quintana E., Sandoval E., Tellez A., Tolosana J. M., Vidal B., Falces C., Fuster D., Garcia-De-la-Maria C., Hernandez-Meneses M., Llopis J., Marco F., Ruiz-Zamora I., Bardaji Ruiz A., Sanz Girgas E., Garcia-Pardo G., Guillen Marzo M., Rodriguez Oviedo A., Villares Jimenez A., Abid L., Ham-Mami R., Kammoun S., Mourali M. S., Mghaieth Zghal F., Ben Hlima M., Boudiche S., Ouali S., Zakhama L., Antit S., Slama I., Gulel O., Sahin M., Karacaglar E., Kucukoglu S., Cetinarslan O., Sinan U. Y., Canpolat U., Mutlu B., Atas H., Dervishova R., Ileri C., Alhashmi J., Tahir J., Zarger P., Baslib F., Woldman S., Menezes L., Primus C., Uppal R., Bvekerwa I., Chandrasekaran B., Kopanska A., Chambers J., Hancock J., Klein J., Rajani R., Ursi M. P., Cannata S., Fife A., Breeze J., Browne-Morgan M., Gunning M., Streather S., Zemedkun M., Alyavi B., and Uzokov J.
Abstract: Aims Infective endocarditis (IE) is a life-threatening disease associated with high mortality and morbidity worldwide. We sought to determine how socioeconomic factors might influence its epidemiology, clinical presentation, investigation and management, and outcome, in a large international multicentre registry. Methods and results The EurObservational Programme (EORP) of the European Society of Cardiology EURO-ENDO (European Infective Endocarditis) registry comprises a prospective cohort of 3113 adult patients admitted for IE in 156 hospitals in 40 countries between January 2016 and March 2018. Patients were separated in three groups, according to World Bank economic stratification [group 1: high income (75.6%); group 2: upper-middle income (15.4%); group 3: lower-middle income (9.1%)]. Group 3 patients were younger [median age (interquartile range, IQR): group 1, 66 (53-75) years; group 2, 57 (41-68) years; group 3, 33 (26-43) years; P < 0.001] with a higher frequency of smokers, intravenous drug use, and human immunodeficiency virus infection (all P < 0.001) and presented later [median (IQR) days since symptom onset: group 1, 12 (3-35); group 2, 19 (6-54); group 3, 31 (12-62); P < 0.001] with a higher likelihood of developing congestive heart failure (13.6%, 11.1%, and 22.6%, respectively; P < 0.001) and persistent fever (9.8%, 14.2%, and 27.9%, respectively; P < 0.001). Among 2157 (69.3%) patients with theoretical indication for cardiac surgery, surgery was performed less frequently in group 3 patients (75.5%, 76.8%, and 51.3%, respectively; P < 0.001), who also demonstrated the highest mortality (15.0%, 23.0%, and 23.7%, respectively; P < 0.001). Conclusion Socioeconomic factors influence the clinical profile of patients presenting with IE across the world. Despite younger age, patients from the poorest countries presented with more frequent complications and higher mortality associated with delayed diagnosis and lower use of surgery.
Published: 2023

54. In-plane optical spectroscopy study on FeSe epitaxial thin film grown on SrTiO$_3$ substrate

Author: Yuan, R. H., Kong, W. D., Yan, L., Ding, H., and Wang, N. L.
Subjects: Condensed Matter - Superconductivity
Abstract: We perform in-plane optical spectroscopy measurement on (00l) FeSe thin-film grown on SrTiO$_3$ substrate by pulsed laser deposition method. The study indicates that the low frequency conductivity consists of two Drude components, a broad one which takes up most of the spectral weight and a very narrow one roughly below 100-150 \cm. The narrow Drude component locates at so low frequencies that no such behavior was observed in iron pnictides. The overall plasma frequency is found to be smaller than the FeAs based compounds, suggesting a stronger correlation effect. Similar to iron pnictides, a temperature-induced spectral weight transfer is observed for FeSe. However, the relevant energy scale is lower. Additionally, different from a recent ARPES measurement which revealed a spin density wave (SDW) order at low temperature for FeSe thin films grown on SrTiO$_3$ substrate, no signature of the band structure reconstruction arising from the formation of the SDW order is seen by optical measurement in the thick FeSe films., Comment: 5 pages, 4 figures
Published: 2013
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55. Preparation and investigation of structure, magnetic, and dielectric properties of (1 − x)Bi2Fe4O9–xMgFe2O4 bicomponent ceramics

Author: Wang, L. G., Yu, G. B., Zhu, C. M., Lv, F. Z., Liu, F. C., and Kong, W. J.
Published: 2019
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56. Comparison of Methods for Measuring Radiotherapy Utilisation

Author: Mackillop, W.J. and Kong, W.
Published: 2019
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57. Far-Infrared Spectroscopy of Cationic Polycyclic Aromatic Hydrocarbons: Zero Kinetic Energy Photoelectron Spectroscopy of Pentacene Vaporized from Laser Desorption

Author: Zhang, J., Han, F., Pei, L., Kong, W., and Li, Aigen
Subjects: Astrophysics - Astrophysics of Galaxies, Physics - Chemical Physics
Abstract: The distinctive set of infrared (IR) emission bands at 3.3, 6.2, 7.7, 8.6, and 11.3{\mu}m are ubiquitously seen in a wide variety of astrophysical environments. They are generally attributed to polycyclic aromatic hydrocarbon (PAH) molecules. However, not a single PAH species has yet been identified in space, as the mid-IR vibrational bands are mostly representative of functional groups and thus do not allow one to fingerprint individual PAH molecules. In contrast, the far-IR (FIR) bands are sensitive to the skeletal characteristics of a molecule, hence they are important for chemical identification of unknown species. With an aim to offer laboratory astrophysical data for the Herschel Space Observatory, Stratospheric Observatory for Infrared Astronomy, and similar future space missions, in this work we report neutral and cation FIR spectroscopy of pentacene (C_22H_14), a five-ring PAH molecule. We report three IR active modes of cationic pentacene at 53.3, 84.8, and 266{\mu}m that may be detectable by space missions such as the SAFARI instrument on board SPICA. In the experiment, pentacene is vaporized from a laser desorption source and cooled by a supersonic argon beam. We have obtained results from two-color resonantly enhanced multiphoton ionization and two-color zero kinetic energy photoelectron (ZEKE) spectroscopy. Several skeletal vibrational modes of the first electronically excited state of the neutral species and those of the cation are assigned, with the aid of ab initio and density functional calculations., Comment: 27 pages, 5 figures, 4 tables; published in ApJ
Published: 2012
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58. On Blowup in Nonlinear Heat Equations

Author: Egli, D., Gang, Z., Kong, W., and Sigal, I. M.
Subjects: Mathematics - Analysis of PDEs, 35K55, 35B44
Abstract: We establish the asymptotics of blowup for nonlinear heat equations with superlinear power nonlinearities in arbitrary dimensions and we estimate the remainders., Comment: 45 pages. arXiv admin note: substantial text overlap with arXiv:math/0609161
Published: 2011

59. Application and prognostic relevance of CD34 detection in immunophenotyping of pediatric acute B lymphoblastic leukemia.

Author: ZHA, W., YUAN, Y., YANG, T., ZHU, L.-J., KONG, W.-Y., and ZHUO, J.-J.
Abstract: OBJECTIVE: We aimed to investigate the application of CD34 detection in immunophenotypic discrimination and its prognostic relevance in children with acute B-lymphoblastic leukemia (B-ALL). PATIENTS AND METHODS: A retrospective analysis was conducted on clinical follow-up data of 105 children with newly diagnosed B-ALL treated at our hospital from January 2022 to December 2023. Based on the expression of CD34 in the bone marrow, patients were divided into a CD34 positive group (positive cells >10%) and a CD34 negative group (positive cells <10%). The study compared the positive rates of common leukemia cell antigens, clinical characteristics, initial treatment responses, and long-term follow-up outcomes between the two groups. RESULTS: Among all 105 B-ALL cases, 87 children (82.9%) had bone marrow CD34 positive cells >10%, classified into the CD34 positive group, while the remaining 18 children (17.1%) had bone marrow CD34 positive cells <10%, classified into the CD34 negative group. The CD34 positive group exhibited significantly higher positive rates of CD13 expression, standard-risk B-ALL, and risk stratification than the CD34 negative group. In contrast, the proportions of early pre-BALL, E2A-PBX1 fusion gene, and MLL-AF4 fusion gene were significantly lower in the CD34 negative group, with statistically significant differences (p<0.05). No significant differences were found in the positive rates of leukemia cell antigens such as CD10, CD19, CD20, CD22, CD79a, CD13, CD33, and CD38 between the two groups (p>0.05). The occurrence rates of minimal residual disease (MRD) and relapse after induction chemotherapy in the CD34 positive group were significantly lower than those in the CD34 negative group (p<0.05). However, the sensitivity to the first prednisone treatment and bone marrow treatment efficacy on the 19th and 33rd days after chemotherapy showed no significant differences between the groups (p>0.05). CONCLUSIONS: A higher positive rate of bone marrow CD34 expression in children with B-ALL is associated with a favorable prognosis. Children with negative CD34 expression are relatively more prone to MRD and tumor relapse after chemotherapy. [ABSTRACT FROM AUTHOR]
Published: 2024

60. Clinical characteristics and outcomes of left ventricular thrombus patients with mildly reduced and preserved left ventricular ejection fraction

Author: Goh, F, primary, Teo, Y N, additional, Teo, Y H, additional, Leow, A S T, additional, Chan, M Y Y, additional, Yeo, L L L, additional, Kong, W K F, additional, Poh, K K, additional, Ho, J S Y, additional, Yeo, T C, additional, Tan, B Y Q, additional, and Sia, C H, additional
Published: 2023
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61. Differences in clinical characteristics and outcomes between patients with left ventricular thrombus following non-anterior and anterior ST-elevation myocardial infarction

Author: Goh, F, primary, Teo, Y N, additional, Teo, Y H, additional, Leow, A S T, additional, Chan, M Y Y, additional, Yeo, L L L, additional, Kong, W K F, additional, Poh, K K, additional, Ho, J S Y, additional, Yeo, T C, additional, Tan, B Y Q, additional, and Sia, C H, additional
Published: 2023
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62. Factors influencing the detection rate of fumarate peak in 1H MR spectroscopy of fumarate hydratase-deficient renal cell carcinoma at 3 T MRI

Author: Pan, S., primary, Wang, J., additional, Liu, G., additional, Zhang, J., additional, Song, Y., additional, Kong, W., additional, Zhou, Y., additional, and Wu, G., additional
Published: 2023
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63. Impact of addition of ca on clogging of SEN and magnetic properties of non-oriented silicon steel

Author: Kong W. and Cang D.G.
Subjects: addition of ca, sen clogging, magnetic property, non-oriented silicon steel., Mining engineering. Metallurgy, TN1-997
Abstract: The submerged entry nozzle (SEN) clogging has been happening during continuous casting (or CC for short) for nonoriented silicon steel. To solve the problem, the paper studied a flow rate through SEN, a node attached to one of them, and the impact on the clogging. The results showed that when SEN is clogged seriously, the casting speed has to decrease below the target casting speed and that SEN clogging can be predicted by comparing the actual value and the theoretical one of a casting speed. Al2O3 and its composite inclusions caused the SEN clogging and the addition of Ca can solve SEN clogging during CC of the silicon steel both theoretically and practically. Furthermore, the impact of the addition of Ca on the magnetic properties of the steel were analyzed. The results showed that the core loss and the magnetic induction of the silicon steel decreased by using the addition of Ca, which generated more dissolved Aluminum, and the addition of Ca generated more harmful textures, which reduced the magnetic induction.
Published: 2019
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64. Development of a structural model for quality cultural heritage tourism

Author: Kong, W. H.
Subjects: 658
Abstract: The aim of this research is to develop and test a theoretical model of quality cultural heritage tourism. It offers an integrated approach to understanding cultural heritage development and management of tourist destinations, and attempts to extend the theoretical and empirical evidence regarding causal relationships including quality of experience, perceived quality, satisfaction and behavioural intentions. The previous literature has already presented the relationship among perceived quality, quality of experience, satisfaction and behavioural intentions in cultural heritage tourism. However, there is a relative lack of academic interest, particularly in Macao. Thus, this research tries to investigate the quality and related constructs in cultural heritage tourism. It seeks to understand the major constructs considered by local stakeholders and visitors in evaluating the quality in cultural heritage tourism, the importance of the availability of quality in the overall experience, visitors‘ behaviour toward quality cultural heritage tourism and also the constructs related to quality. The methodological approach of this research includes qualitative and quantitative methods in the field research in Macao, China. Semi-structured interviews with Macao stakeholders and a questionnaire survey with Macao visitors were used for data collection. A structural model of the relationships between perceived quality, quality of experience, satisfaction and behavioural intentions was tested SEM used in quantitative study tested the validity, reliability and potential of the quality models developed from literature reviews and grounded theory. The findings provide further evidence for the importance of perceived quality and quality of experience as the major constructs in the development of cultural heritage tourism and as a strategic objective which emphasises it as the core construct in cultural heritage tourism. The study also examines whether there is a relationship between quality of experience, perceived quality, satisfaction and behavioural intentions in cultural heritage tourism. The findings show that perceived quality leads to quality of experience and satisfaction. In addition, it suggests that perceived quality and satisfaction are the important determinants of behavioural intentions. An unexpected finding concerned the antecedents of perceived quality and the empirical results from the structural modelling presented in the study shows that authenticity, interpretations and behavioural intentions in cultural heritage tourism can affect the perceived quality which affects the quality of experience and their satisfaction indirectly. These results have generated a new concept in the literature. From the managerial standpoint, the findings offer suggestions for the future direction of cultural heritage tourism. It can enable researchers into cultural heritage tourism to gain a better understanding between these constructs and has shown an emerging consensus in their interrelationships. The tourism providers can improve quality of experience and perceived quality in cultural heritage tourism in order to develop effective strategies. Since cultural heritage tourism has been shown to be increasing and substantial, it should be beneficial for the destinations to examine the quality attributes and constructs that influence travelling and returning to cultural heritage destinations. By understanding the relationships between quality constructs, the tourism providers would better know how to develop cultural heritage tourism and improve the strategies to maximise its benefits. These findings are particularly useful to tourism providers because they provide directions for the implementation of sustainable cultural heritage tourism.
Published: 2010

65. Enhanced room-temperature magnetoelectric effect in xBi0.5Na0.5TiO3-(1-x)NiFe2O4 ceramics by magnetic field annealing

Author: Wang, L. G., Zhu, C. M., Yuan, S. L., Liu, F. C., He, Y., Yang, H., and Kong, W. J.
Published: 2019
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66. Observation of a Logarithmic Temperature Dependence of Thermoelectric Power on Multiwall Carbon Nanotubes

Author: Kang, N., Lu, L., Kong, W. J., Hu, J. S., Yi, W., Wang, Y. P., Zhang, D. L., Pan, Z. W., and Xie, S. S.
Subjects: Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Disordered Systems and Neural Networks
Abstract: We have investigated the thermoelectric power (TEP) of millimeter-long aligned multiwall carbon nanotubes down to a temperature of $T$=1.5 K, and observed for the first time an accurate $T {\rm ln} T$ dependence at low temperatures. This behavior is possibly originated from the repulsive interaction between the electrons in a disordered local environment., Comment: 3 pages, 3 figures
Published: 2002

67. A qualitative study on the attitudes of patients with gastrointestinal cancer toward being informed of the truth

Author: Yang F, Zhang Q, Kong W, Shen H, Lu J, Ge X, and Zhuang Y
Subjects: Gastrointestinal cancer patients, Disclosure of diagnosis, Qualitative study, Medicine (General), R5-920
Abstract: Feimin Yang,1 Qian Zhang,1 Wei Kong,1 Hongdan Shen,1 Jing Lu,1 Xiaolong Ge,1 Yiyu Zhuang2 1Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, China; 2Nursing Department, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, China Objective: The aim of this study is to investigate the attitudes of hospitalized patients with gastrointestinal cancer toward being informed of the truth and to provide references for informing patients of their gastrointestinal cancer diagnosis.Methods: Nine patients with gastrointestinal cancer were selected for this study by using a purposive sampling technique from a general surgery ward in a tertiary-level general hospital in Zhejiang Province from June 2016 to October 2016. Semi-structured, in-depth interviews were conducted, and the descriptive phenomenological method (developed by Amedeo Giorgi) was used to analyze the interview data.Results: Five themes were developed through reading, analysis, reflection, and classification of the data: Theme 1, guessing the diagnosis of gastrointestinal cancer before being informed of the truth; Theme 2, eagerness to know the diagnosis results; Theme 3, expectations related to beginning treatment for cancer; Theme 4, stress and anxiety during treatment; and Theme 5, providing patients with hope and optimism at the early diagnosis stage.Conclusion: Patients have a strong desire to survive and can confidently confront their gastrointestinal cancer diagnosis. Medical staff should carefully select the appropriate time to inform patients of their diagnosis by evaluating their attitudes toward being informed, thereby actively meeting patients’ needs for information and treatment. Keywords: patient with gastrointestinal cancer, disclosure of diagnosis, qualitative study
Published: 2018

68. Surgery and outcome of infective endocarditis in octogenarians: prospective data from the ESC EORP EURO-ENDO registry

Author: Pazdernik, Michal, Iung, Bernard, Mutlu, Bulent, Alla, François, Riezebos, Robert, Kong, William, Nunes, Maria Carmo Pereira, Pierard, Luc, Srdanovic, Ilija, Yamada, Hirotsugu, de Martino, Andrea, Miglioranza, Marcelo Haertel, Magne, Julien, Piper, Cornelia, Laroche, C. cile, Maggioni, Aldo P., Lancellotti, Patrizio, Habib, Gilbert, Selton-Suty, Christine, Ronderos, R., Avegliano, G., Oses, P. Fernandez, Filipini, E., Granada, I., Iribarren, A., Mahia, M., Nacinovich, F., Ressi, S., Obregon, R., Bangher, M., Dho, J., Cartasegna, L., Plastino, M. L., Novas, V., Shigel, C., Reyes, G., de Santos, M., Gastaldello, N., Fernandez, M. Granillo, Potito, M., Streitenberger, G., Velazco, P., Casabé, J. H., Cortes, C., Guevara, E., Salmo, F., Seijo, M., Weidinger, F., Heger, M., Brooks, R., Stöllberger, C., Ho, C. Y., Perschy, L., Puskas, L., Goliasch, G., Binder, C., Rosenhek, R., Schneider, M., Winter, M. P., Hoffer, E., Melissopoulou, M., Lecoq, E., Legrand, D., Jacquet, S., Massoz, M., Lancellotti, P., Pierard, L., Dulgheru, R., Marchetta, S., D´Emal, C., Oury, C., Cosyns, B., Droogmans, S., Kerkhove, D., Motoc, A., Plein, D., Roosens, B., Soens, L., Weytjens, C., Lemoine, I., Rodrigus, I., Paelinck, B., Amsel, B., Unger, P., Konopnicki, D., Beauloye, C., Pasquet, A., Pierard, S., Vancraeynest, D., Vanoverschelde, J. L., Sinnaeve, F., Andrade, J. L., Rodrigues, A. C. Tude, Staszko, K., Dos Santos Monteiro, R., Miglioranza, M. H., Shuha, D. L., Alcantara, M., Cravo, V., Fazzio, L., Felix, A., Iso, M., Musa, C., Siciliano, A. P., Filho, F. Villaca, Braga, J., Rodrigues, A., Silva, R., Vilela, F., Rodrigues, D., Silva, L., Morhy, S., Fischer, C., Vieira, M., Afonso, T., Abreu, J., Falcao, S. N., Moises, V., Gouvea, A., João, G., Mancuso, F., Silva, C., Souza, A. C., Abboud, C. S., de Mattos Barretto, R. Bellio, Ramos, A., Arnoni, R., Assef, J. E., Togna, D. J. Della, le Bihan, D., Miglioli, L., Oliveira, A. P. Romero, Kroll, R. Tadeu Magro, Cortez, D., Gelape, C. L., Nunes, M. d. C. Peirira, de Abreu Ferrari, T. C., Chan, K. L., Hay, K., le, V., Page, M., Poulin, F., Sauve, C., Serri, K., Mercure, C., Beaudoin, J., Pibarot, P., Sebag, I., Rudski, L., Ricafort, G., Barsic, B., Krajinovic, V., Vargovic, M., Separovic-Hanzevacki, J., Lovric, D., Reskovic-Luksic, V., Vincelj, J., Jurinjak, S. Jaksic, Yiannikourides, V., Ioannides, M., Kyriakou, C., Pofaides, C., Masoura, V., Yiangou, K., Pudich, J., Linhart, A., Siranec, M., Marek, J., Blechova, K., Kamenik, M., Pazdernik, M., Pelouch, R., Coufal, Z., Mikulica, M., Griva, M., Jancova, E., Mikulcova, M., Taborsky, M., Precek, J., Jecmenova, M., Latal, J., Widimsky, J., Butta, T., Machacek, S., Vancata, R., Spinar, J., Holicka, M., Long, F. Pow Chon, Anzules, N., Carpio, A. Bajana, Largacha, G., Penaherrera, E., Moreira, D., Mahfouz, E., Elsafty, E., Soliman, A., Zayed, Y., Aboulenein, J., Abdel-Hay, M., Almaghraby, A., Abdelnaby, M., Ahmed, M., Hammad, B., Saleh, Y., Zahran, H., Elgebaly, O., Saad, A., Ali, M., Zeid, A., Sharkawy, R. El, Meshaal, M., Al Kholy, A., Doss, R., Osama, D., Rizk, H., Elmogy, A., Mishriky, M., Assayag, P., Hatimi, S. El, Botelho-Nevers, Saint- E., Campisi, S., Fuzellier, J. F., Gagneux-Brunon, A., Pierrard, R., Tulane, C., Detoc, M., Mehalla, T., Boutoille, D., Al Habash, O., Asseray-Madani, N., Biron, C., Brochard, J., Caillon, J., Cueff, C., le Tourneau, T., Lecompte, A. S., Lecomte, R., Lefebvre, M., Michel, M. M. Magali, Pattier, S., Delarue, S., le Bras, M., Orain, J., Faucher, J. F., Aboyans, V., Beeharry, A., Durox, H., Lacoste, M., Magne, J., Mohty, D., David, A., Pradel, V., Sierra, V., Neykova, A., Bettayeb, B., Elkentaoui, S., Tzvetkov, B., Landry, G., Strady, C., Ainine, K., Baumard, S., Brasselet, C., Tassigny, C., Valente-Pires, V., Lefranc, M., Hoen, B., Lefevre, B., Curlier, E., Callier, C., Fourcade, N., Jobic, Y., Ansard, S., le Berre, R., le Roux, P., le Ven, F., Pouliquen, M. C., Prat, G., Bouchart, F., Savoure, A., Alarcon, C., Chapuzet, C., Gueit, I., Tribouilloy, C., Bohbot, Y., Peugnet, F., Gun, M., Iung, B., Duval, X., Lescure, X., Ilic-Habensus, E., Sadoul, N., Selton-Suty, C., Alla, F., Chevalier, E., Goehringer, F., Huttin, O., Garcia, R., le Marcis, V., Tattevin, P., Donal, E., Flecher, E., Revest, M., Habib, G., Hubert, S., Casalta, J. P., Gouriet, F., Arregle, F., Cammilleri, S., Tessonnier, L., Riberi, A., Chirouze, C., Bouiller, K., Brunel, A. S., Fournier, D., Hustache-Mathieu, L., Klopfenstein, T., Moreau, J., Lim, P., Oliver, L., Ternacle, J., Moussafeur, A., Chavanet, P., Piroth, L., Buisson, M., Mahy, S., Martins, C., Salmon-Rousseau, A., Gohier, S., Piper, C., Börgermann, J., Guckel, D., Horstkotte, D., Brockmeier, B., Winkelmann, E., Hagendorff, A., Grey, D., Nickenig, G., Schueler, R., Öztürk, C., Stöhr, E., Hamm, C., Walther, T., Brandt, R., Frühauf, A. C., Hartung, C. T., Hellner, C., Wild, C., Becker, M., Hamada, S., Kaestner, W., Stangl, K., Knebel, F., Baldenhofer, G., Brecht, A., Dreger, H., Isner, C., Pfafflin, F., Stegemann, M., Zahn, R., Fraiture, B., Kilkowski, C., Karcher, A. K., Klinger, S., Tolksdorf, H., Tousoulis, D., Aggeli, C., Sarri, G., Sideris, S., Venieri, E., Athanassopoulos, G., Tsiapras, D., Armenis, I., Koutsiari, A., Floros, G., Grassos, C., Dragasis, S., Rallidis, L., Varlamos, C., Michalis, L., Naka, K., Bechlioulis, A., Kotsia, A., Lakkas, L., Pappas, K., Papadopoulos, C., Kiokas, S., Lioni, A., Misailidou, S., Barbetseas, J., Bonou, M., Kapelios, C., Tomprou, I., Zerva, K., Manolis, A., Hamodraka, E., Athanasiou, D., Haralambidis, G., Poulimenos, L., Samaras, H., Nagy, A., Bartykowszki, A., Gara, E., Sengupta, S., Mungulmare, K., Kasliwal, R., Bansal, M., Bhan, A., Ranjan, S., Kyavar, M., Maleki, M., Bezanjani, F. Noohi, Sadeghpour, A., Alizadehasl, A., Boudagh, S., Ghavidel, A., Moradnejad, P., Pasha, H. R., Ghadrdoost, B., Gilon, D., Strahilevitz, J., Israel, S., Wanounou, M., d’Agostino, C., Colonna, P., de Michele, L., Fumarola, F., Stante, M., Marchionni, N., Scheggi, V., Alterini, B., del Pace, S., Stefano, P., Sparano, C., Badano, L. P., Muraru, D., Ruozi, N., Tenaglia, R., Limbruno, U., Cresti, A., Baratta, P., Solari, M., Giannattasio, C., Moreo, A., de Chiara, B., Montero, B. Lopez, Musca, F., Orcese, C. A., Panzeri, F., Russo, C. F., Spano, F., Alfieri, O., de Bonis, M., Agricola, E., Busnardo, E., Carletti, S., Castiglioni, B., Chiappetta, S., del Forno, B., Ferrara, D., Guffanti, M., Iaci, G., Lapenna, E., Nisi, T., Oltolini, C., Pajoro, U., Pasciuta, R., Ripa, M., Scarpellini, P., Din, C. Tassan, Meneghin, R., Schiavi, D., Piscione, F., Citro, R., Benvenga, R. M., Greco, L., Prota, C., Radano, I., Soriente, L., Bellino, M., di Vece, D., Santini, F., Salsano, A., Olivieri, G. 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Monteagudo, J, Elorza, E, Alvarez, M, Balbin, J, Arminanzas, C, de las Revillas, F, Garcia, A, Belaustegui, M, Sampedro, M, Cuadra, M, Gutierrez-Diez, J, Zarauza, J, Cuello, L, Rico, C, Rodriguez-Alvarez, R, Goikoetxea, J, Montejo, M, Miro, J, Almela, M, Ambrosioni, J, Falces, C, Fuster, D, Garcia-de-la-Maria, C, Hernandez-Meneses, M, Llopis, J, Marco, F, Moreno, A, Quintana, E, Sandoval, E, Tellez, A, Tolosana, J, Vidal, B, Ruiz-Zamora, I, Ruiz, A, Girgas, E, Garcia-Pardo, G, Marzo, M, Oviedo, A, Jimenez, A, Abid, L, Hammami, R, Kammoun, S, Mourali, M, Zghal, F, Hlima, M, Boudiche, S, Ouali, S, Zakhama, L, Antit, S, Slama, I, Gulel, O, Sahin, M, Sade, L, Karacaglar, E, Kucukoglu, S, Cetinarslan, O, Yasar, U, Canpolat, U, Atas, H, Dervishova, R, Ileri, C, Zaky, H, Alhashmi, J, Baslib, F, Tahir, J, Zarger, P, Woldman, S, Menezes, L, Primus, C, Uppal, R, Bvekerwa, I, Chandrasekaran, B, Kopanska, A, Prendergast, B, Cannata, S, Chambers, J, Hancock, J, Klein, J, Rajani, R, Ursi, M, Dworakowski, R, Fife, A, Breeze, J, Browne-Morgan, M, Gunning, M, Streather, S, Asch, F, Zemedkun, M, Alyavi, B, Uzokov, J, Clinical sciences, Cardio-vascular diseases, Medical Imaging, Pazdernik M., Iung B., MUTLU B., Alla F., Riezebos R., Kong W., Pereira Nunes M. C., Pierard L., Srdanovic I., Yamada H., et al., Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Cardiology Dept, CHU Limoges, INSERM 1094, University Hospital Dupuytren, 87042, Limoges, Epidémiologie des Maladies Chroniques en zone tropicale (EpiMaCT), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-OmégaHealth (ΩHealth), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Département de Cardiologie [Hôpital de la Timone - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, European Infective Endocarditis Registry (Euro-Endo), Abbott Vascular, AstraZeneca, ResMed, Sanofi, Servier, Vifor Pharma, Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Pfizer, Daiichi Sankyo Europe, Eli Lilly and Company, Gedeon Richter, and Novartis Pharma
Subjects: Microbiology (medical), Prognosi, Immunology, Infective endocarditi, Life Sciences (LIFE), INTERNATIONAL COLLABORATION, PROFILE, AGE, Elderly, Propensity analysis, Yaşam Bilimleri, Health Sciences, RISK, İmmünoloji, General Immunology and Microbiology, Infective endocarditis, Prognosis, Surgery, Temel Bilimler, Life Sciences, General Medicine, INFECTIOUS DISEASES, MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, BULAŞICI HASTALIKLAR, Yaşam Bilimleri (LIFE), [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Propensity analysi, Natural Sciences
Abstract: Purpose: High mortality and a limited performance of valvular surgery are typical features of infective endocarditis (IE) in octogenarians, even though surgical treatment is a major determinant of a successful outcome in IE. Methods: Data from the prospective multicentre ESC EORP EURO-ENDO registry were used to assess the prognostic role of valvular surgery depending on age. Results: As compared to < 80yo patients, ≥ 80yo had lower rates of theoretical indication for valvular surgery (49.1% vs. 60.3%, p < 0.001), of surgery performed (37.0% vs. 75.5%, p < 0.001), and a higher in-hospital (25.9% vs. 15.8%, p < 0.001) and 1-year mortality (41.3% vs. 22.2%, p < 0.001). By multivariable analysis, age per se was not predictive of 1-year mortality, but lack of surgical procedures when indicated was strongly predictive (HR 2.98 [2.43–3.66]). By propensity analysis, 304 ≥ 80yo were matched to 608 < 80yo patients. Propensity analysis confirmed the lower rate of indication for valvular surgery (51.3% vs. 57.2%, p = 0.031) and of surgery performed (35.3% vs. 68.4%, p < 0.0001) in ≥ 80yo. Overall mortality remained higher in ≥ 80yo (in-hospital: HR 1.50[1.06–2.13], p = 0.0210; 1-yr: HR 1.58[1.21–2.05], p = 0.0006), but was not different from that of < 80yo among those who had surgery (in-hospital: 19.7% vs. 20.0%, p = 0.4236; 1-year: 27.3% vs. 25.5%, p = 0.7176). Conclusion: Although mortality rates are consistently higher in ≥ 80yo patients than in < 80yo patients in the general population, mortality of surgery in ≥ 80yo is similar to < 80yo after matching patients. These results confirm the importance of a better recognition of surgical indication and of an increased performance of surgery in ≥ 80yo patients.
Published: 2022

69. The structural dynamic of transmembrane protein FtsQ, FtsB and FtsL in the FtsQBL complex formation

Author: Kong, W. P., primary, Gong, F., additional, So, P. K., additional, Chen, Y. W., additional, Chan, P. H., additional, Leung, Y. C., additional, and Wong, K. Y., additional
Published: 2023
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70. Spin–orbit torque switching in a T-type magnetic configuration with current orthogonal to easy axes

Author: Kong, W. J., Wan, C. H., Wang, X., Tao, B. S., Huang, L., Fang, C., Guo, C. Y., Guang, Y., Irfan, M., and Han, X. F.
Published: 2019
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71. Characteristics, management, and outcomes of patients with left-sided infective endocarditis complicated by heart failure: a substudy of the ESC-EORP EURO-ENDO (European infective endocarditis) registry

Author: Bohbot, Y, Habib, G, Laroche, C, Stohr, E, Chirouze, C, Hernandez-Meneses, M, Melissopoulou, M, Mutlu, B, Scheggi, V, Branco, L, Olmos, C, Reyes, G, Pazdernik, M, Iung, B, Sow, R, Mirocevic, M, Lancellotti, P, Tribouilloy, C, Gale, C, Beleslin, B, Budaj, A, Chioncel, O, Dagres, N, Danchin, N, Emberson, J, Erlinge, D, Glikson, M, Gray, A, Kayikcioglu, M, Maggioni, A, Nagy, V, Nedoshivin, A, Petronio, A, Roos-Hesselink, J, Wallentin, L, Zeymer, U, Cosyns, B, Donal, E, Erba, P, Popescu, B, Prendergast, B, Tornos, P, Andarala, M, Berle, C, Brunel-Lebecq, A, Fiorucci, E, Missiamenou, V, Taylor, C, Ali Tatar-Chentir, N, Al-Mallah, M, Astrom Aneq, M, Athanassopoulos, G, Badano, L, Benyoussef, S, Calderon Aranda, E, Cardim, N, Chan, K, Cruz, I, Edvardsen, T, Goliasch, G, Hagendorff, A, Hristova, K, Kamp, O, Kang, D, Kong, W, Matskeplishvili, S, Meshaal, M, Neskovic, A, Plonska-Gosciniak, E, Raissouni, M, Ronderos, R, Sade, L, Sadeghpour, A, Sambola, A, Sengupta, S, Separovic-Hanzevacki, J, Takeuchi, M, Tucay, E, Tude Rodrigues, A, Varga, A, Vaskelyte, J, Yamagata, K, Yiangou, K, Zaky, H, Granada, I, Mahia, M, Ressi, S, Nacinovich, F, Iribarren, A, Fernandez Oses, P, Avegliano, G, Filipini, E, Obregon, R, Bangher, M, Dho, J, Cartasegna, L, Plastino, M, Novas, V, Shigel, C, De Santos, M, Gastaldello, N, Granillo Fernandez, M, Potito, M, Streitenberger, G, Velazco, P, Casabe, J, Cortes, C, Guevara, E, Salmo, F, Seijo, M, Weidinger, F, Heger, M, Brooks, R, Stollberger, C, Ho, C, Perschy, L, Puskas, L, Binder, C, Rosenhek, R, Schneider, M, Winter, M, Hoffer, E, Lecoq, E, Legrand, D, Jacquet, S, Massoz, M, Pierard, L, Marchetta, S, Dulgheru, R, D'Emal, C, Oury, C, Droogmans, S, Kerkhove, D, Plein, D, Soens, L, Weytjens, C, Motoc, A, Roosens, B, Lemoine, I, Rodrigus, I, Paelinck, B, Amsel, B, Unger, P, Konopnicki, D, Beauloye, C, Pasquet, A, Vanoverschelde, J, Pierard, S, Vancraeynest, D, Sinnaeve, F, Andrade, J, Staszko, K, Dos Santos Monteiro, R, 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R., Ghadrdoost B., Gilon D., Strahilevitz J., Wanounou M., Israel S., d'Agostino C., Colonna P., De Michele L., Fumarola F., Stante M., Marchionni N., Alterini B., Del Pace S., Stefano P., Sparano C., Ruozi N., Tenaglia R., Muraru D., Limbruno U., Cresti A., Baratta P., Solari M., Giannattasio C., Moreo A., De Chiara B., Lopez Montero B., Musca F., Orcese C. A., Panzeri F., Spano F., Russo C. F., Alfieri O., De Bonis M., Chiappetta S., Del Forno B., Ripa M., Scarpellini P., Tassan Din C., Castiglioni B., Pasciuta R., Carletti S., Ferrara D., Guffanti M., Iaci G., Lapenna E., Nisi T., Oltolini C., Busnardo E., Pajoro U., Agricola E., Meneghin R., Schiavi D., Piscione F., Citro R., Benvenga R. M., Greco L., Soriente L., Radano I., Prota C., Bellino M., Di Vece D., Santini F., Salsano A., Olivieri G. M., Turrini F., Messora R., Tondi S., Olaru A., Agnoletto V., Grassi L., Leonardi C., Sansoni S., Del Ponte S., Actis Dato G. 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L., Jacobs-Orazi L., Mallia Azzopardi C., Xuereb R. G., Piscopo T., Farrugia J., Fenech M., Pllaha E., Vella C., Borg D., Casha R., Grib L., Raevschi E., Grejdieru A., Kravcenco D., Prisacari E., Samohvalov E., Samohvalov S., Sceglova N., Panfile E., Cardaniuc L., Corcea V., Feodorovici A., Gaina V., Girbu L., Jimbei P., Balan G., Cardaniuc I., Benesco I., Marian V., Sumarga N., Bozovic B., Bulatovic N., Lakovic P., Music L., Budde R., Wahadat A., Gamela T., Meijers T., Van Melle J. P., Deursen V. M., Crijns H. J., Bekkers S. C., Cheriex E. C., Gilbers M., Kietselaer B. L., Knackstedt C., Lorusso R., Schalla S., Streukens S. A., Chamuleau S., Cramer M. -J., Teske A., Van der Spoel T., Wind A., Lokhorst J., Liesbek O., Van Heusden H., Tanis W., Van der Bilt I., Vriend J., De Lange-van Bruggen H., Karijodikoro E., Riezebos R., van Dongen E., Schoep J., Stolk V., Offstad J. T., Beitnes J. O., Helle-Valle T., Skulstad H., Skardal R., Qamar N., Furnaz S., Ahmed B., Butt M. H., Khanzada M. F., Saghir T., Wahid A., Hryniewiecki T., Szymanski P., Marzec K., Misztal-Ogonowska M., Kosmala W., Przewlocka-Kosmala M., Rojek A., Woznicka K., Zachwyc J., Lisowska A., Kaminska M., Kasprzak J. D., Kowalczyk E., Strzecka D. F., Wejner-Mik P., Trabulo M., Freitas P., Ranchordas S., Rodrigues G., Pinto P., Queiros C., Azevedo J., Marques L., Seabra D., Cruz M., Galrinho A., Moreira R., Rio P., Timoteo A. T., Selas M., Carmelo V., Duque Neves B., Pereira H., Guerra A., Marques A., Pintassilgo I., Tomescu M. C., Trofenciuc N. -M., Andor M., Bordejevic A., Branea H. S., Caruntu F., Velcean L. A., Mavrea A., Onel M. F., Parvanescu T., Pop D., Pop-Moldovan A. L., Puticiu M. I., Cirin L., Citu I. M., Cotoraci C. 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M., Vidal B., Falces C., Fuster D., Garcia-de-la-Maria C., Llopis J., Marco F., Ruiz-Zamora I., Bardaji Ruiz A., Sanz Girgas E., Garcia-Pardo G., Guillen Marzo M., Rodriguez Oviedo A., Villares Jimenez A., Abid L., Hammami R., Kammoun S., Mourali M. S., Mghaieth Zghal F., Ben Hlima M., Boudiche S., Ouali S., Zakhama L., Antit S., Slama I., Gulel O., Sahin M., Karacaglar E., Kucukoglu S., Cetinarslan O., Sinan U. Y., Canpolat U., Atas H., Dervishova R., Ileri C., Alhashmi J., Tahir J., Zarger P., Baslib F., Woldman S., Menezes L., Primus C., Uppal R., Bvekerwa I., Chandrasekaran B., Kopanska A., Chambers J., Hancock J., Klein J., Rajani R., Ursi M. P., Cannata S., Dworakowski R., Fife A., Breeze J., Browne-Morgan M., Gunning M., Streather S., Asch F. M., Zemedkun M., Alyavi B., and Uzokov J.
Abstract: Aims: To evaluate the current management and survival of patients with left-sided infective endocarditis (IE) complicated by congestive heart failure (CHF) in the ESC-EORP European Endocarditis (EURO-ENDO) registry. Methods and results: Among the 3116 patients enrolled in this prospective registry, 2449 (mean age: 60 years, 69% male) with left-sided (native or prosthetic) IE were included in this study. Patients with CHF (n = 698, 28.5%) were older, with more comorbidity and more severe valvular damage (mitro-aortic involvement, vegetations >10 mm and severe regurgitation/new prosthesis dehiscence) than those without CHF (all p ≤ 0.019). Patients with CHF experienced higher 30-day and 1-year mortality than those without (20.5% vs. 9.0% and 36.1% vs. 19.3%, respectively) and CHF remained strongly associated with 30-day (odds ratio[OR] 2.37, 95% confidence interval [CI] [1.73–3.24; p < 0.001) and 1-year mortality (hazard ratio [HR] 1.69, 95% CI 1.39–2.05; p < 0.001) after adjustment for established outcome predictors, including early surgery, or after propensity matching for age, sex, and comorbidity (n = 618 [88.5%] for each group, both p < 0.001). Early surgery, performed on 49% of these patients with IE complicated by CHF, remained associated with a substantial reduction in 30-day mortality following multivariable analysis, after adjustment for age, sex, Charlson comorbidity index, cerebrovascular accident, Staphylococcus aureus IE, streptococcal IE, uncontrolled infection, vegetation size >10 mm, severe valvular regurgitation and/or new prosthetic dehiscence, perivalvular complication, and prosthetic IE (OR 0.22, 95% CI 0.12–0.38; p < 0.001) and in 1-year mortality (HR 0.29, 95% CI 0.20–0.41; p < 0.001). Conclusion: Congestive heart failure is common in left-sided IE and is associated with older age, greater comorbidity, more advanced lesions, and markedly higher 30-day and 1-year mortality. Early surgery is strongly associated with lower mort
Published: 2022

72. Correction to: Surgery and outcome of infective endocarditis in octogenarians: prospective data from the ESC EORP EURO-ENDO registry (Infection, (2022), 50, 5, (1191-1202), 10.1007/s15010-022-01792-0)

Author: Pazdernik M., Pazdernik, M, Iung, B, Mutlu, B, Alla, F, Riezebos, R, Kong, W, Nunes, M, Pierard, L, Srdanovic, I, Yamada, H, De Martino, A, Miglioranza, M, Magne, J, Piper, C, Laroche, C, Maggioni, A, Lancellotti, P, Habib, G, Selton-Suty, C, Ronderos, R, Avegliano, G, Oses, P, Filipini, E, Granada, I, Iribarren, A, Mahia, M, Nacinovich, F, Ressi, S, Obregon, R, Bangher, M, Dho, J, Cartasegna, L, Plastino, M, Novas, V, Shigel, C, Reyes, G, De Santos, M, Gastaldello, N, Fernandez, M, Potito, M, Streitenberger, G, Velazco, P, Casabe, J, Cortes, C, Guevara, E, Salmo, F, Seijo, M, Weidinger, F, Heger, M, Brooks, R, Stollberger, C, Ho, C, Perschy, L, Puskas, L, Goliasch, G, Binder, C, Rosenhek, R, Schneider, M, Winter, M, Hoffer, E, Melissopoulou, M, Lecoq, E, Legrand, D, Jacquet, S, Massoz, M, Dulgheru, R, Marchetta, S, D'Emal, C, Oury, C, Cosyns, B, Droogmans, S, Kerkhove, D, Motoc, A, Plein, D, Roosens, B, Soens, L, Weytjens, C, Lemoine, I, Rodrigus, I, Paelinck, B, Amsel, B, Unger, P, Konopnicki, D, Beauloye, C, Pasquet, A, Pierard, S, Vancraeynest, D, Vanoverschelde, J, Sinnaeve, F, Andrade, J, Rodrigues, A, Staszko, K, Dos Santos Monteiro, R, Shuha, D, Alcantara, M, Cravo, V, Fazzio, L, Felix, A, Iso, M, Musa, C, Siciliano, A, Filho, F, Braga, J, Silva, R, Vilela, F, Rodrigues, D, Silva, L, Morhy, S, Fischer, C, Vieira, M, Afonso, T, Abreu, J, Falcao, S, Moises, V, Gouvea, A, Joao, G, Mancuso, F, Silva, C, Souza, A, Abboud, C, de Mattos Barretto, R, Ramos, A, Arnoni, R, Assef, J, Togna, D, Le Bihan, D, Miglioli, L, Oliveira, A, Kroll, R, Cortez, D, Gelape, C, De Abreu Ferrari, T, Chan, K, Hay, K, Le, V, Page, M, Poulin, F, Sauve, C, Serri, K, Mercure, C, Beaudoin, J, Pibarot, P, Sebag, I, Rudski, L, Ricafort, G, Barsic, B, Krajinovic, V, Vargovic, M, Separovic-Hanzevacki, J, Lovric, D, Reskovic-Luksic, V, Vincelj, J, Jurinjak, S, Yiannikourides, V, Ioannides, M, Kyriakou, C, Pofaides, C, Masoura, V, Yiangou, K, Pudich, J, Linhart, A, Siranec, M, Marek, 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L., Michaux C., Staub T., Jacobs-Orazi L., Azzopardi C. M., Xuereb R. G., Piscopo T., Borg D., Casha R., Farrugia J., Fenech M., Pllaha E., Vella C., Yamagata K., Grib L., Raevschi E., Grejdieru A., Balan G., Cardaniuc I., Cardaniuc L., Corcea V., Feodorovici A., Gaina V., Girbu L., Jimbei P., Kravcenco D., Panfile E., Prisacari E., Samohvalov E., Samohvalov S., Sceglova N., Benesco I., Marian V., Sumarga N., Mirocevic M., Bozovic B., Bulatovic N., Lakovic P., Music L., Roos-Hesselink J., Budde R., Gamela T., Wahadat A., Kamp O., Meijers T., Van Melle J. P., Deursen V. M., Crijns H., Bekkers S., Cheriex E., Gilbers M., Kietselaer B., Knackstedt C., Lorusso R., Schalla S., Streukens S., Chamuleau S., Cramer M. -J., Teske A., Van der Spoel T., Wind A., Liesbek O., Lokhorst J., Van Heusden H., Tanis W., Van der Bilt I., Vriend J., De Lange-van Bruggen H., Karijodikoro E., van Dongen E., Schoep J., Stolk V., Axler O., Baumann F., Lebras S., Edvardsen T., Offstad J. T., Beitnes J. O., Helle-Valle T., Skulstad H., Skardal R., Qamar N., Furnaz S., Ahmed B., Butt M. H., Khanzada M. F., Saghir T., Wahid A., Hryniewiecki T., Szymanski P., Marzec K., Misztal-Ogonowska M., Kosmala W., Przewlocka-Kosmala M., Rojek A., Woznicka K., Zachwyc J., Lisowska A., Kaminska M., Kasprzak J., Kowalczyk E., Strzecka D. F., Wejner-Mik P., Trabulo M., Freitas P., Ranchordas S., Rodrigues G., Pinto P., Queiros C., Azevedo J., Marques L., Seabra D., Branco L., Cruz M., Galrinho A., Moreira R., Rio P., Timoteo A. T., Selas M., Cardim N. M., Carmelo V., Neves B. D., Pereira H., Cruz I., Guerra A., Marques A., Pintassilgo I., Tomescu M. C., Trofenciuc N. -M., Andor M., Bordejevic A., Branea H. S., Caruntu F., Cirin L., Citu I. M., Cotoraci C. A., Darabantiu D., Farcas R., Marincu I., Mavrea A., Onel M. F., Parvanescu T., Pop D., Pop-Moldovan A. L., Puticiu M. I., Velcean L. A., Ionac A., Cozma D., Mornos C., Goanta F., Popescu I., Beyer R., Mada R., Rancea R., Rosianu H., Tomoaia R., Stanescu C., Kobalava Z., Karaulova J., Kotova E., Milto A., Pisaryuk A., Povalyaev N., Sorokina M., Alrahimi J., Elshiekh A., Jamiel A., Ahmed A., Al-Mallah M., Attia N., Putnikovic B., Neskovic A., Dimic A., Ivanovic B., Matic S., Trifunovic D., Petrovic J., Kosevic D., Dabic P., Milojevic P., Petrovic I., Stojanovic I., Kovacevic M., Redzek A., Stefanovic M., Susak S., Velicki L., Vulin A., Yeo T. C., Kong W. K. F., Poh K. K., Vilacosta I., El-Nasser M. A., Ferrera C., Olmos C., Iglesias F. C., Blanco-Gonzalez E., Amaro M. B., Germinas A. N., Lopez-Rodriguez E., Adan J. L., Pazos-Lopez P., Loureiro M. P., Perez M. T., Raposeiras-Roubin S., Yas S. R., Suarez-Varela M. -M., Vidal F. V., Garcia-Dorado D., Sambola A., Fernandez-Hidalgo N., Gonzalez-Alujas T., Lozano J., Maisterra O., Pizzi N., Rios R., Tornos P., Bayes-Genis A., Botet L. P., Vallejo N., Berastegui E., Llibre C., Mateu L., Nunez R., Quesada D., Portell D. B., Vinas J. A., Bertran X. A., Tarradellas R. B., Ricon P. L. -O., de Llano C. T., Arnau M. A., Bel A., Blanes M., Osa A., Anguita M., Carrasco F., Castillo J., Zamorano J. L., Mur J. L. M., Alvaro M., Fernandez-Golfin C., Monteagudo J. M., Elorza E. N., Alvarez M. C. F., Balbin J. A., Arminanzas C., de las Revillas F. A., Garcia A. A., Belaustegui M. C., Sampedro M. F., Cuadra M. G., Gutierrez-Diez J. F., Zarauza J., Cuello L. G., Rico C. G., Rodriguez-Alvarez R., Goikoetxea J., Montejo M., Miro J., Almela M., Ambrosioni J., Falces C., Fuster D., Garcia-de-la-Maria C., Hernandez-Meneses M., Llopis J., Marco F., Moreno A., Quintana E., Sandoval E., Tellez A., Tolosana J. M., Vidal B., Ruiz-Zamora I., Ruiz A. B., Girgas E. S., Garcia-Pardo G., Marzo M. G., Oviedo A. R., Jimenez A. V., Abid L., Hammami R., Kammoun S., Mourali M. S., Zghal F. M., Hlima M. B., Boudiche S., Ouali S., Zakhama L., Antit S., Slama I., Gulel O., Sahin M., Sade L. E., Karacaglar E., Kucukoglu S., Cetinarslan O., Sinan U. Y., Canpolat U., Atas H., Dervishova R., Ileri C., Zaky H., Alhashmi J., Baslib F., Tahir J., Zarger P., Woldman S., Menezes L., Primus C., Uppal R., Bvekerwa I., Chandrasekaran B., Kopanska A., Prendergast B., Cannata S., Chambers J., Hancock J., Klein J., Rajani R., Ursi M. P., Dworakowski R., Fife A., Breeze J., Browne-Morgan M., Gunning M., Streather S., Asch F., Zemedkun M., Alyavi B., and Uzokov J.
Published: 2022

73. Surgery and outcome of infective endocarditis in octogenarians: prospective data from the ESC EORP EURO-ENDO registry

Author: Pazdernik, M, Iung, B, Mutlu, B, Alla, F, Riezebos, R, Kong, W, Nunes, M, Pierard, L, Srdanovic, I, Yamada, H, De Martino, A, Miglioranza, M, Magne, J, Piper, C, Laroche, C, Maggioni, A, Lancellotti, P, Habib, G, Selton-Suty, C, Ronderos, R, Avegliano, G, Oses, P, Filipini, E, Granada, I, Iribarren, A, Mahia, M, Nacinovich, F, Ressi, S, Obregon, R, Bangher, M, Dho, J, Cartasegna, L, Plastino, M, Novas, V, Shigel, C, Reyes, G, De Santos, M, Gastaldello, N, Fernandez, M, Potito, M, Streitenberger, G, Velazco, P, Casabe, J, Cortes, C, Guevara, E, Salmo, F, Seijo, M, Weidinger, F, Heger, M, Brooks, R, Stollberger, C, Ho, C, Perschy, L, Puskas, L, Goliasch, G, Binder, C, Rosenhek, R, Schneider, M, Winter, M, Hoffer, E, Melissopoulou, M, Lecoq, E, Legrand, D, Jacquet, S, Massoz, M, Dulgheru, R, Marchetta, S, Demal, C, Oury, C, Cosyns, B, Droogmans, S, Kerkhove, D, Motoc, A, Plein, D, Roosens, B, Soens, L, Weytjens, C, Lemoine, I, Rodrigus, I, Paelinck, B, Amsel, B, Unger, P, Konopnicki, D, Beauloye, C, Pasquet, A, Pierard, S, Vancraeynest, D, Vanoverschelde, J, Sinnaeve, F, Andrade, J, Rodrigues, A, Staszko, K, Dos Santos Monteiro, R, Shuha, D, Alcantara, M, Cravo, V, Fazzio, L, Felix, A, Iso, M, Musa, C, Siciliano, A, Filho, F, Braga, J, Silva, R, Vilela, F, Rodrigues, D, Silva, L, Morhy, S, Fischer, C, Vieira, M, Afonso, T, Abreu, J, Falcao, S, Moises, V, Gouvea, A, Joao, G, Mancuso, F, Silva, C, Souza, A, Abboud, C, de Mattos Barretto, R, Ramos, A, Arnoni, R, Assef, J, Togna, D, Le Bihan, D, Miglioli, L, Oliveira, A, Kroll, R, Cortez, D, Gelape, C, De Abreu Ferrari, T, Chan, K, Hay, K, Le, V, Page, M, Poulin, F, Sauve, C, Serri, K, Mercure, C, Beaudoin, J, Pibarot, P, Sebag, I, Rudski, L, Ricafort, G, Barsic, B, Krajinovic, V, Vargovic, M, Separovic-Hanzevacki, J, Lovric, D, Reskovic-Luksic, V, Vincelj, J, Jurinjak, S, Yiannikourides, V, Ioannides, M, Kyriakou, C, Pofaides, C, Masoura, V, Yiangou, K, Pudich, J, Linhart, A, Siranec, M, Marek, J, Blechova, K, Kamenik, M, Pelouch, R, Coufal, Z, Mikulica, M, Griva, M, Jancova, E, Mikulcova, M, Taborsky, M, Precek, J, Jecmenova, M, Latal, J, Widimsky, J, Butta, T, Machacek, S, Vancata, R, Spinar, J, Holicka, M, Long, F, Anzules, N, Carpio, A, Largacha, G, Penaherrera, E, Moreira, D, Mahfouz, E, Elsafty, E, Soliman, A, Zayed, Y, Aboulenein, J, Abdel-Hay, M, Almaghraby, A, Abdelnaby, M, Ahmed, M, Hammad, B, Saleh, Y, Zahran, H, Elgebaly, O, Saad, A, Ali, M, Zeid, A, Sharkawy, R, Meshaal, M, Al Kholy, A, Doss, R, Osama, D, Rizk, H, Elmogy, A, Mishriky, M, Assayag, P, Hatimi, S, Botelho-Nevers, S, Campisi, S, Fuzellier, J, Gagneux-Brunon, A, Pierrard, R, Tulane, C, Detoc, M, Mehalla, T, Boutoille, D, Al Habash, O, Asseray-Madani, N, Biron, C, Brochard, J, Caillon, J, Cueff, C, Le Tourneau, T, Lecompte, A, Lecomte, R, Lefebvre, M, Michel, M, Pattier, S, Delarue, S, Le Bras, M, Orain, J, Faucher, J, Aboyans, V, Beeharry, A, Durox, H, Lacoste, M, Mohty, D, David, A, Pradel, V, Sierra, V, Neykova, A, Bettayeb, B, Elkentaoui, S, Tzvetkov, B, Landry, G, Strady, C, Ainine, K, Baumard, S, Brasselet, C, Tassigny, C, Valente-Pires, V, Lefranc, M, Hoen, B, Lefevre, B, Curlier, E, Callier, C, Fourcade, N, Jobic, Y, Ansard, S, Le Berre, R, Le Roux, P, Le Ven, F, Pouliquen, M, Prat, G, Bouchart, F, Savoure, A, Alarcon, C, Chapuzet, C, Gueit, I, Tribouilloy, C, Bohbot, Y, Peugnet, F, Gun, M, Duval, X, Lescure, X, Ilic-Habensus, E, Sadoul, N, Chevalier, E, Goehringer, F, Huttin, O, Garcia, R, Le Marcis, V, Tattevin, P, Donal, E, Flecher, E, Revest, M, Hubert, S, Casalta, J, Gouriet, F, Arregle, F, Cammilleri, S, Tessonnier, L, Riberi, A, Chirouze, C, Bouiller, K, Brunel, A, Fournier, D, Hustache-Mathieu, L, Klopfenstein, T, Moreau, J, Lim, P, Oliver, L, Ternacle, J, Moussafeur, A, Chavanet, P, Piroth, L, Buisson, M, Mahy, S, Martins, C, Salmon-Rousseau, A, Gohier, S, Borgermann, J, Guckel, D, Horstkotte, D, Brockmeier, B, Winkelmann, E, Hagendorff, A, Grey, D, Nickenig, G, Schueler, R, Ozturk, C, Stohr, E, Hamm, C, Walther, T, Brandt, R, Fruhauf, A, Hartung, C, Hellner, C, Wild, C, Becker, M, Hamada, S, Kaestner, W, Stangl, K, Knebel, F, Baldenhofer, G, Brecht, A, Dreger, H, Isner, C, Pfafflin, F, Stegemann, M, Zahn, R, Fraiture, B, Kilkowski, C, Karcher, A, Klinger, S, Tolksdorf, H, Tousoulis, D, Aggeli, C, Sarri, G, Sideris, S, Venieri, E, Athanassopoulos, G, Tsiapras, D, Armenis, I, Koutsiari, A, Floros, G, Grassos, C, Dragasis, S, Rallidis, L, Varlamos, C, Michalis, L, Naka, K, Bechlioulis, A, Kotsia, A, Lakkas, L, Pappas, K, Papadopoulos, C, Kiokas, S, Lioni, A, Misailidou, S, Barbetseas, J, Bonou, M, Kapelios, C, Tomprou, I, Zerva, K, Manolis, A, Hamodraka, E, Athanasiou, D, Haralambidis, G, Poulimenos, L, Samaras, H, Nagy, A, Bartykowszki, A, Gara, E, Sengupta, S, Mungulmare, K, Kasliwal, R, Bansal, M, Bhan, A, Ranjan, S, Kyavar, M, Maleki, M, Bezanjani, F, Sadeghpour, A, Alizadehasl, A, Boudagh, S, Ghavidel, A, Moradnejad, P, Pasha, H, Ghadrdoost, B, Gilon, D, Strahilevitz, J, Israel, S, Wanounou, M, D'Agostino, C, Colonna, P, De Michele, L, Fumarola, F, Stante, M, Marchionni, N, Scheggi, V, Alterini, B, Del Pace, S, Stefano, P, Sparano, C, Badano, L, Muraru, D, Ruozi, N, Tenaglia, R, Limbruno, U, Cresti, A, Baratta, P, Solari, M, Giannattasio, C, Moreo, A, De Chiara, B, Montero, B, Musca, F, Orcese, C, Panzeri, F, Russo, C, Spano, F, Alfieri, O, De Bonis, M, Agricola, E, Busnardo, E, Carletti, S, Castiglioni, B, Chiappetta, S, Del Forno, B, Ferrara, D, Guffanti, M, Iaci, G, Lapenna, E, Nisi, T, Oltolini, C, Pajoro, U, Pasciuta, R, Ripa, M, Scarpellini, P, Din, C, Meneghin, R, Schiavi, D, Piscione, F, Citro, R, Benvenga, R, Greco, L, Prota, C, Radano, I, Soriente, L, Bellino, M, Di Vece, D, Santini, F, Salsano, A, Olivieri, G, Turrini, F, Messora, R, Tondi, S, Olaru, A, Agnoletto, V, Grassi, L, Leonardi, C, Sansoni, S, Del Ponte, S, Dato, G, Ohte, N, Kikuchi, S, Wakami, K, Aonuma, K, Seo, Y, Ishizu, T, Machino-Ohtsuka, T, Yamamoto, M, Iida, N, Nakajima, H, Nakagawa, Y, Izumi, C, Amano, M, Miyake, M, Takahashi, K, Shiojima, I, Miyasaka, Y, Maeba, H, Suwa, Y, Taniguchi, N, Tsujimoto, S, Kitai, T, Ota, M, Yuda, S, Sasaki, S, Hagiwara, N, Yamazaki, K, Ashihara, K, Arai, K, Saitou, C, Saitou, S, Suzuki, G, Shibata, Y, Watanabe, N, Nishino, S, Ashikaga, K, Kuriyama, N, Mahara, K, Abe, K, Fujimaki, H, Okubo, T, Shitan, H, Takanashi, S, Terada, M, Yamamoto, H, Sata, M, Kusunose, K, Saijo, Y, Seno, H, Yuichiro, O, Sakata, Y, Mizuno, H, Nakatani, S, Onishi, T, Sengoku, K, Sera, F, Park, S, Kyoung, K, Yeon, L, Hwang, J, Jin-Oh, C, Sang-Chol, L, Sung-A, C, Jang, S, Kang, D, Heo, R, Lee, S, Song, J, Jung, E, Plisiene, J, Dambrauskaite, A, Gruodyte, G, Jonkaitiene, R, Vaskelyte, J, Mizariene, V, Atkocaityte, J, Zvirblyte, R, Sow, R, Codreanu, A, De la Vega, E, Michaux, C, Staub, T, Jacobs-Orazi, L, Azzopardi, C, Xuereb, R, Piscopo, T, Borg, D, Casha, R, Farrugia, J, Fenech, M, Pllaha, E, Vella, C, Yamagata, K, Grib, L, Raevschi, E, Grejdieru, A, Balan, G, Cardaniuc, I, Cardaniuc, L, Corcea, V, Feodorovici, A, Gaina, V, Girbu, L, Jimbei, P, Kravcenco, D, Panfile, E, Prisacari, E, Samohvalov, E, Samohvalov, S, Sceglova, N, Benesco, I, Marian, V, Sumarga, N, Mirocevic, M, Bozovic, B, Bulatovic, N, Lakovic, P, Music, L, Roos-Hesselink, J, Budde, R, Gamela, T, Wahadat, A, Kamp, O, Meijers, T, Van Melle, J, Deursen, V, Crijns, H, Bekkers, S, Cheriex, E, Gilbers, M, Kietselaer, B, Knackstedt, C, Lorusso, R, Schalla, S, Streukens, S, Chamuleau, S, Cramer, M, Teske, A, Van der Spoel, T, Wind, A, Liesbek, O, Lokhorst, J, Van Heusden, H, Tanis, W, Van der Bilt, I, Vriend, J, De Lange-van Bruggen, H, Karijodikoro, E, van Dongen, E, Schoep, J, Stolk, V, Axler, O, Baumann, F, Lebras, S, Edvardsen, T, Offstad, J, Beitnes, J, Helle-Valle, T, Skulstad, H, Skardal, R, Qamar, N, Furnaz, S, Ahmed, B, Butt, M, Khanzada, M, Saghir, T, Wahid, A, Hryniewiecki, T, Szymanski, P, Marzec, K, Misztal-Ogonowska, M, Kosmala, W, Przewlocka-Kosmala, M, Rojek, A, Woznicka, K, Zachwyc, J, Lisowska, A, Kaminska, M, Kasprzak, J, Kowalczyk, E, Strzecka, D, Wejner-Mik, P, Trabulo, M, Freitas, P, Ranchordas, S, Rodrigues, G, Pinto, P, Queiros, C, Azevedo, J, Marques, L, Seabra, D, Branco, L, Cruz, M, Galrinho, A, Moreira, R, Rio, P, Timoteo, A, Selas, M, Cardim, N, Carmelo, V, Neves, B, Pereira, H, Cruz, I, Guerra, A, Marques, A, Pintassilgo, I, Tomescu, M, Trofenciuc, N, Andor, M, Bordejevic, A, Branea, H, Caruntu, F, Cirin, L, Citu, I, Cotoraci, C, Darabantiu, D, Farcas, R, Marincu, I, Mavrea, A, Onel, M, Parvanescu, T, Pop, D, Pop-Moldovan, A, Puticiu, M, Velcean, L, Ionac, A, Cozma, D, Mornos, C, Goanta, F, Popescu, I, Beyer, R, Mada, R, Rancea, R, Rosianu, H, Tomoaia, R, Stanescu, C, Kobalava, Z, Karaulova, J, Kotova, E, Milto, A, Pisaryuk, A, Povalyaev, N, Sorokina, M, Alrahimi, J, Elshiekh, A, Jamiel, A, Ahmed, A, Al-Mallah, M, Attia, N, Putnikovic, B, Neskovic, A, Dimic, A, Ivanovic, B, Matic, S, Trifunovic, D, Petrovic, J, Kosevic, D, Dabic, P, Milojevic, P, Petrovic, I, Stojanovic, I, Kovacevic, M, Redzek, A, Stefanovic, M, Susak, S, Velicki, L, Vulin, A, Yeo, T, Poh, K, Vilacosta, I, Nasser, M, Ferrera, C, Olmos, C, Iglesias, F, Blanco-Gonzalez, E, Amaro, M, Germinas, A, Lopez-Rodriguez, E, Adan, J, Pazos-Lopez, P, Loureiro, M, Perez, M, Raposeiras-Roubin, S, Yas, S, Suarez-Varela, M, Vidal, F, Garcia-Dorado, D, Sambola, A, Fernandez-Hidalgo, N, Gonzalez-Alujas, T, Lozano, J, Maisterra, O, Pizzi, N, Rios, R, Tornos, P, Bayes-Genis, A, Botet, L, Vallejo, N, Berastegui, E, Llibre, C, Mateu, L, Nunez, R, Quesada, D, Portell, D, Vinas, J, Bertran, X, Tarradellas, R, Ricon, P, de Llano, C, Arnau, M, Bel, A, Blanes, M, Osa, A, Anguita, M, Carrasco, F, Castillo, J, Zamorano, J, Mur, J, Alvaro, M, Fernandez-Golfin, C, Monteagudo, J, Elorza, E, Alvarez, M, Balbin, J, Arminanzas, C, de las Revillas, F, Garcia, A, Belaustegui, M, Sampedro, M, Cuadra, M, Gutierrez-Diez, J, Zarauza, J, Cuello, L, Rico, C, Rodriguez-Alvarez, R, Goikoetxea, J, Montejo, M, Miro, J, Almela, M, Ambrosioni, J, Falces, C, Fuster, D, Garcia-de-la-Maria, C, Hernandez-Meneses, M, Llopis, J, Marco, F, Moreno, A, Quintana, E, Sandoval, E, Tellez, A, Tolosana, J, Vidal, B, Ruiz-Zamora, I, Ruiz, A, Girgas, E, Garcia-Pardo, G, Marzo, M, Oviedo, A, Jimenez, A, Abid, L, Hammami, R, Kammoun, S, Mourali, M, Zghal, F, Hlima, M, Boudiche, S, Ouali, S, Zakhama, L, Antit, S, Slama, I, Gulel, O, Sahin, M, Sade, L, Karacaglar, E, Kucukoglu, S, Cetinarslan, O, Yasar, U, Canpolat, U, Atas, H, Dervishova, R, Ileri, C, Zaky, H, Alhashmi, J, Baslib, F, Tahir, J, Zarger, P, Woldman, S, Menezes, L, Primus, C, Uppal, R, Bvekerwa, I, Chandrasekaran, B, Kopanska, A, Prendergast, B, Cannata, S, Chambers, J, Hancock, J, Klein, J, Rajani, R, Ursi, M, Dworakowski, R, Fife, A, Breeze, J, Browne-Morgan, M, Gunning, M, Streather, S, Asch, F, Zemedkun, M, Alyavi, B, Uzokov, J, Pazdernik M., Iung B., Mutlu B., Alla F., Riezebos R., Kong W., Nunes M. C. P., Pierard L., Srdanovic I., Yamada H., De Martino A., Miglioranza M. H., Magne J., Piper C., Laroche C., Maggioni A. P., Lancellotti P., Habib G., Selton-Suty C., Ronderos R., Avegliano G., Oses P. F., Filipini E., Granada I., Iribarren A., Mahia M., Nacinovich F., Ressi S., Obregon R., Bangher M., Dho J., Cartasegna L., Plastino M. L., Novas V., Shigel C., Reyes G., De Santos M., Gastaldello N., Fernandez M. G., Potito M., Streitenberger G., Velazco P., Casabe J. H., Cortes C., Guevara E., Salmo F., Seijo M., Weidinger F., Heger M., Brooks R., Stollberger C., Ho C. -Y., Perschy L., Puskas L., Goliasch G., Binder C., Rosenhek R., Schneider M., Winter M. -P., Hoffer E., Melissopoulou M., Lecoq E., Legrand D., Jacquet S., Massoz M., Dulgheru R., Marchetta S., DEmal C., Oury C., Cosyns B., Droogmans S., Kerkhove D., Motoc A., Plein D., Roosens B., Soens L., Weytjens C., Lemoine I., Rodrigus I., Paelinck B., Amsel B., Unger P., Konopnicki D., Beauloye C., Pasquet A., Pierard S., Vancraeynest D., Vanoverschelde J. L., Sinnaeve F., Andrade J. L., Rodrigues A. C. T., Staszko K., Dos Santos Monteiro R., Shuha D. L., Alcantara M., Cravo V., Fazzio L., Felix A., Iso M., Musa C., Siciliano A. P., Filho F. V., Braga J., Rodrigues A., Silva R., Vilela F., Rodrigues D., Silva L., Morhy S., Fischer C., Vieira M., Afonso T., Abreu J., Falcao S. N., Moises V., Gouvea A., Joao G., Mancuso F., Silva C., Souza A. C., Abboud C. S., de Mattos Barretto R. B., Ramos A., Arnoni R., Assef J. E., Togna D. J. D., Le Bihan D., Miglioli L., Oliveira A. P. R., Kroll R. T. M., Cortez D., Gelape C. L., De Abreu Ferrari T. C., Chan K. -L., Hay K., Le V., Page M., Poulin F., Sauve C., Serri K., Mercure C., Beaudoin J., Pibarot P., Sebag I., Rudski L., Ricafort G., Barsic B., Krajinovic V., Vargovic M., Separovic-Hanzevacki J., Lovric D., Reskovic-Luksic V., Vincelj J., Jurinjak S. J., Yiannikourides V., Ioannides M., Kyriakou C., Pofaides C., Masoura V., Yiangou K., Pudich J., Linhart A., Siranec M., Marek J., Blechova K., Kamenik M., Pelouch R., Coufal Z., Mikulica M., Griva M., Jancova E., Mikulcova M., Taborsky M., Precek J., Jecmenova M., Latal J., Widimsky J., Butta T., Machacek S., Vancata R., Spinar J., Holicka M., Long F. P. C., Anzules N., Carpio A. B., Largacha G., Penaherrera E., Moreira D., Mahfouz E., Elsafty E., Soliman A., Zayed Y., Aboulenein J., Abdel-Hay M., Almaghraby A., Abdelnaby M., Ahmed M., Hammad B., Saleh Y., Zahran H., Elgebaly O., Saad A., Ali M., Zeid A., Sharkawy R. E., Meshaal M., Al Kholy A., Doss R., Osama D., Rizk H., Elmogy A., Mishriky M., Assayag P., Hatimi S. E., Botelho-Nevers S. -E., Campisi S., Fuzellier J. -F., Gagneux-Brunon A., Pierrard R., Tulane C., Detoc M., Mehalla T., Boutoille D., Al Habash O., Asseray-Madani N., Biron C., Brochard J., Caillon J., Cueff C., Le Tourneau T., Lecompte A. S., Lecomte R., Lefebvre M., Michel M. M. M., Pattier S., Delarue S., Le Bras M., Orain J., Faucher J. -F., Aboyans V., Beeharry A., Durox H., Lacoste M., Mohty D., David A., Pradel V., Sierra V., Neykova A., Bettayeb B., Elkentaoui S., Tzvetkov B., Landry G., Strady C., Ainine K., Baumard S., Brasselet C., Tassigny C., Valente-Pires V., Lefranc M., Hoen B., Lefevre B., Curlier E., Callier C., Fourcade N., Jobic Y., Ansard S., Le Berre R., Le Roux P., Le Ven F., Pouliquen M. -C., Prat G., Bouchart F., Savoure A., Alarcon C., Chapuzet C., Gueit I., Tribouilloy C., Bohbot Y., Peugnet F., Gun M., Duval X., Lescure X., Ilic-Habensus E., Sadoul N., Chevalier E., Goehringer F., Huttin O., Garcia R., Le Marcis V., Tattevin P., Donal E., Flecher E., Revest M., Hubert S., Casalta J. -P., Gouriet F., Arregle F., Cammilleri S., Tessonnier L., Riberi A., Chirouze C., Bouiller K., Brunel A. -S., Fournier D., Hustache-Mathieu L., Klopfenstein T., Moreau J., Lim P., Oliver L., Ternacle J., Moussafeur A., Chavanet P., Piroth L., Buisson M., Mahy S., Martins C., Salmon-Rousseau A., Gohier S., Borgermann J., Guckel D., Horstkotte D., Brockmeier B., Winkelmann E., Hagendorff A., Grey D., Nickenig G., Schueler R., Ozturk C., Stohr E., Hamm C., Walther T., Brandt R., Fruhauf A. -C., Hartung C. T., Hellner C., Wild C., Becker M., Hamada S., Kaestner W., Stangl K., Knebel F., Baldenhofer G., Brecht A., Dreger H., Isner C., Pfafflin F., Stegemann M., Zahn R., Fraiture B., Kilkowski C., Karcher A. -K., Klinger S., Tolksdorf H., Tousoulis D., Aggeli C., Sarri G., Sideris S., Venieri E., Athanassopoulos G., Tsiapras D., Armenis I., Koutsiari A., Floros G., Grassos C., Dragasis S., Rallidis L., Varlamos C., Michalis L., Naka K., Bechlioulis A., Kotsia A., Lakkas L., Pappas K., Papadopoulos C., Kiokas S., Lioni A., Misailidou S., Barbetseas J., Bonou M., Kapelios C., Tomprou I., Zerva K., Manolis A., Hamodraka E., Athanasiou D., Haralambidis G., Poulimenos L., Samaras H., Nagy A., Bartykowszki A., Gara E., Sengupta S., Mungulmare K., Kasliwal R., Bansal M., Bhan A., Ranjan S., Kyavar M., Maleki M., Bezanjani F. N., Sadeghpour A., Alizadehasl A., Boudagh S., Ghavidel A., Moradnejad P., Pasha H. R., Ghadrdoost B., Gilon D., Strahilevitz J., Israel S., Wanounou M., d'Agostino C., Colonna P., De Michele L., Fumarola F., Stante M., Marchionni N., Scheggi V., Alterini B., Del Pace S., Stefano P., Sparano C., Badano L., Muraru D., Ruozi N., Tenaglia R., Limbruno U., Cresti A., Baratta P., Solari M., Giannattasio C., Moreo A., De Chiara B., Montero B. L., Musca F., Orcese C. A., Panzeri F., Russo C. F., Spano F., Alfieri O., De Bonis M., Agricola E., Busnardo E., Carletti S., Castiglioni B., Chiappetta S., Del Forno B., Ferrara D., Guffanti M., Iaci G., Lapenna E., Nisi T., Oltolini C., Pajoro U., Pasciuta R., Ripa M., Scarpellini P., Din C. T., Meneghin R., Schiavi D., Piscione F., Citro R., Benvenga R. M., Greco L., Prota C., Radano I., Soriente L., Bellino M., Di Vece D., Santini F., Salsano A., Olivieri G. M., Turrini F., Messora R., Tondi S., Olaru A., Agnoletto V., Grassi L., Leonardi C., Sansoni S., Del Ponte S., Dato G. M. 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B., Ramos A., Arnoni R., Assef J. E., Togna D. J. D., Le Bihan D., Miglioli L., Oliveira A. P. R., Kroll R. T. M., Cortez D., Gelape C. L., De Abreu Ferrari T. C., Chan K. -L., Hay K., Le V., Page M., Poulin F., Sauve C., Serri K., Mercure C., Beaudoin J., Pibarot P., Sebag I., Rudski L., Ricafort G., Barsic B., Krajinovic V., Vargovic M., Separovic-Hanzevacki J., Lovric D., Reskovic-Luksic V., Vincelj J., Jurinjak S. J., Yiannikourides V., Ioannides M., Kyriakou C., Pofaides C., Masoura V., Yiangou K., Pudich J., Linhart A., Siranec M., Marek J., Blechova K., Kamenik M., Pelouch R., Coufal Z., Mikulica M., Griva M., Jancova E., Mikulcova M., Taborsky M., Precek J., Jecmenova M., Latal J., Widimsky J., Butta T., Machacek S., Vancata R., Spinar J., Holicka M., Long F. P. C., Anzules N., Carpio A. B., Largacha G., Penaherrera E., Moreira D., Mahfouz E., Elsafty E., Soliman A., Zayed Y., Aboulenein J., Abdel-Hay M., Almaghraby A., Abdelnaby M., Ahmed M., Hammad B., Saleh Y., Zahran H., Elgebaly O., Saad A., Ali M., Zeid A., Sharkawy R. E., Meshaal M., Al Kholy A., Doss R., Osama D., Rizk H., Elmogy A., Mishriky M., Assayag P., Hatimi S. E., Botelho-Nevers S. -E., Campisi S., Fuzellier J. -F., Gagneux-Brunon A., Pierrard R., Tulane C., Detoc M., Mehalla T., Boutoille D., Al Habash O., Asseray-Madani N., Biron C., Brochard J., Caillon J., Cueff C., Le Tourneau T., Lecompte A. S., Lecomte R., Lefebvre M., Michel M. M. M., Pattier S., Delarue S., Le Bras M., Orain J., Faucher J. -F., Aboyans V., Beeharry A., Durox H., Lacoste M., Mohty D., David A., Pradel V., Sierra V., Neykova A., Bettayeb B., Elkentaoui S., Tzvetkov B., Landry G., Strady C., Ainine K., Baumard S., Brasselet C., Tassigny C., Valente-Pires V., Lefranc M., Hoen B., Lefevre B., Curlier E., Callier C., Fourcade N., Jobic Y., Ansard S., Le Berre R., Le Roux P., Le Ven F., Pouliquen M. -C., Prat G., Bouchart F., Savoure A., Alarcon C., Chapuzet C., Gueit I., Tribouilloy C., Bohbot Y., Peugnet F., Gun M., Duval X., Lescure X., Ilic-Habensus E., Sadoul N., Chevalier E., Goehringer F., Huttin O., Garcia R., Le Marcis V., Tattevin P., Donal E., Flecher E., Revest M., Hubert S., Casalta J. -P., Gouriet F., Arregle F., Cammilleri S., Tessonnier L., Riberi A., Chirouze C., Bouiller K., Brunel A. -S., Fournier D., Hustache-Mathieu L., Klopfenstein T., Moreau J., Lim P., Oliver L., Ternacle J., Moussafeur A., Chavanet P., Piroth L., Buisson M., Mahy S., Martins C., Salmon-Rousseau A., Gohier S., Borgermann J., Guckel D., Horstkotte D., Brockmeier B., Winkelmann E., Hagendorff A., Grey D., Nickenig G., Schueler R., Ozturk C., Stohr E., Hamm C., Walther T., Brandt R., Fruhauf A. -C., Hartung C. T., Hellner C., Wild C., Becker M., Hamada S., Kaestner W., Stangl K., Knebel F., Baldenhofer G., Brecht A., Dreger H., Isner C., Pfafflin F., Stegemann M., Zahn R., Fraiture B., Kilkowski C., Karcher A. -K., Klinger S., Tolksdorf H., Tousoulis D., Aggeli C., Sarri G., Sideris S., Venieri E., Athanassopoulos G., Tsiapras D., Armenis I., Koutsiari A., Floros G., Grassos C., Dragasis S., Rallidis L., Varlamos C., Michalis L., Naka K., Bechlioulis A., Kotsia A., Lakkas L., Pappas K., Papadopoulos C., Kiokas S., Lioni A., Misailidou S., Barbetseas J., Bonou M., Kapelios C., Tomprou I., Zerva K., Manolis A., Hamodraka E., Athanasiou D., Haralambidis G., Poulimenos L., Samaras H., Nagy A., Bartykowszki A., Gara E., Sengupta S., Mungulmare K., Kasliwal R., Bansal M., Bhan A., Ranjan S., Kyavar M., Maleki M., Bezanjani F. N., Sadeghpour A., Alizadehasl A., Boudagh S., Ghavidel A., Moradnejad P., Pasha H. R., Ghadrdoost B., Gilon D., Strahilevitz J., Israel S., Wanounou M., d'Agostino C., Colonna P., De Michele L., Fumarola F., Stante M., Marchionni N., Scheggi V., Alterini B., Del Pace S., Stefano P., Sparano C., Badano L., Muraru D., Ruozi N., Tenaglia R., Limbruno U., Cresti A., Baratta P., Solari M., Giannattasio C., Moreo A., De Chiara B., Montero B. L., Musca F., Orcese C. A., Panzeri F., Russo C. F., Spano F., Alfieri O., De Bonis M., Agricola E., Busnardo E., Carletti S., Castiglioni B., Chiappetta S., Del Forno B., Ferrara D., Guffanti M., Iaci G., Lapenna E., Nisi T., Oltolini C., Pajoro U., Pasciuta R., Ripa M., Scarpellini P., Din C. T., Meneghin R., Schiavi D., Piscione F., Citro R., Benvenga R. M., Greco L., Prota C., Radano I., Soriente L., Bellino M., Di Vece D., Santini F., Salsano A., Olivieri G. M., Turrini F., Messora R., Tondi S., Olaru A., Agnoletto V., Grassi L., Leonardi C., Sansoni S., Del Ponte S., Dato G. M. A., Ohte N., Kikuchi S., Wakami K., Aonuma K., Seo Y., Ishizu T., Machino-Ohtsuka T., Yamamoto M., Iida N., Nakajima H., Nakagawa Y., Izumi C., Amano M., Miyake M., Takahashi K., Shiojima I., Miyasaka Y., Maeba H., Suwa Y., Taniguchi N., Tsujimoto S., Kitai T., Ota M., Yuda S., Sasaki S., Hagiwara N., Yamazaki K., Ashihara K., Arai K., Saitou C., Saitou S., Suzuki G., Shibata Y., Watanabe N., Nishino S., Ashikaga K., Kuriyama N., Mahara K., Abe K., Fujimaki H., Okubo T., Shitan H., Takanashi S., Terada M., Yamamoto H., Sata M., Kusunose K., Saijo Y., Seno H., Yuichiro O., Sakata Y., Mizuno H., Nakatani S., Onishi T., Sengoku K., Sera F., Park S. W., Kyoung K. E., Yeon L. G., Hwang J. -W., Jin-Oh C., Park S. -J., Sang-Chol L., Sung-A C., Jang S. Y., Kang D. -H., Heo R., Lee S., Song J. -M., Jung E., Plisiene J., Dambrauskaite A., Gruodyte G., Jonkaitiene R., Vaskelyte J., Mizariene V., Atkocaityte J., Zvirblyte R., Sow R., Codreanu A., De la Vega E. C. L., Michaux C., Staub T., Jacobs-Orazi L., Azzopardi C. M., Xuereb R. G., Piscopo T., Borg D., Casha R., Farrugia J., Fenech M., Pllaha E., Vella C., Yamagata K., Grib L., Raevschi E., Grejdieru A., Balan G., Cardaniuc I., Cardaniuc L., Corcea V., Feodorovici A., Gaina V., Girbu L., Jimbei P., Kravcenco D., Panfile E., Prisacari E., Samohvalov E., Samohvalov S., Sceglova N., Benesco I., Marian V., Sumarga N., Mirocevic M., Bozovic B., Bulatovic N., Lakovic P., Music L., Roos-Hesselink J., Budde R., Gamela T., Wahadat A., Kamp O., Meijers T., Van Melle J. P., Deursen V. M., Crijns H., Bekkers S., Cheriex E., Gilbers M., Kietselaer B., Knackstedt C., Lorusso R., Schalla S., Streukens S., Chamuleau S., Cramer M. -J., Teske A., Van der Spoel T., Wind A., Liesbek O., Lokhorst J., Van Heusden H., Tanis W., Van der Bilt I., Vriend J., De Lange-van Bruggen H., Karijodikoro E., van Dongen E., Schoep J., Stolk V., Axler O., Baumann F., Lebras S., Edvardsen T., Offstad J. T., Beitnes J. O., Helle-Valle T., Skulstad H., Skardal R., Qamar N., Furnaz S., Ahmed B., Butt M. H., Khanzada M. F., Saghir T., Wahid A., Hryniewiecki T., Szymanski P., Marzec K., Misztal-Ogonowska M., Kosmala W., Przewlocka-Kosmala M., Rojek A., Woznicka K., Zachwyc J., Lisowska A., Kaminska M., Kasprzak J., Kowalczyk E., Strzecka D. F., Wejner-Mik P., Trabulo M., Freitas P., Ranchordas S., Rodrigues G., Pinto P., Queiros C., Azevedo J., Marques L., Seabra D., Branco L., Cruz M., Galrinho A., Moreira R., Rio P., Timoteo A. T., Selas M., Cardim N. M., Carmelo V., Neves B. D., Pereira H., Cruz I., Guerra A., Marques A., Pintassilgo I., Tomescu M. C., Trofenciuc N. -M., Andor M., Bordejevic A., Branea H. S., Caruntu F., Cirin L., Citu I. M., Cotoraci C. A., Darabantiu D., Farcas R., Marincu I., Mavrea A., Onel M. F., Parvanescu T., Pop D., Pop-Moldovan A. L., Puticiu M. I., Velcean L. A., Ionac A., Cozma D., Mornos C., Goanta F., Popescu I., Beyer R., Mada R., Rancea R., Rosianu H., Tomoaia R., Stanescu C., Kobalava Z., Karaulova J., Kotova E., Milto A., Pisaryuk A., Povalyaev N., Sorokina M., Alrahimi J., Elshiekh A., Jamiel A., Ahmed A., Al-Mallah M., Attia N., Putnikovic B., Neskovic A., Dimic A., Ivanovic B., Matic S., Trifunovic D., Petrovic J., Kosevic D., Dabic P., Milojevic P., Petrovic I., Stojanovic I., Kovacevic M., Redzek A., Stefanovic M., Susak S., Velicki L., Vulin A., Yeo T. C., Kong W. K. F., Poh K. K., Vilacosta I., Nasser M. A. E., Ferrera C., Olmos C., Iglesias F. C., Blanco-Gonzalez E., Amaro M. B., Germinas A. N., Lopez-Rodriguez E., Adan J. L., Pazos-Lopez P., Loureiro M. P., Perez M. T., Raposeiras-Roubin S., Yas S. R., Suarez-Varela M. -M., Vidal F. V., Garcia-Dorado D., Sambola A., Fernandez-Hidalgo N., Gonzalez-Alujas T., Lozano J., Maisterra O., Pizzi N., Rios R., Tornos P., Bayes-Genis A., Botet L. P., Vallejo N., Berastegui E., Llibre C., Mateu L., Nunez R., Quesada D., Portell D. B., Vinas J. A., Bertran X. A., Tarradellas R. B., Ricon P. L. -O., de Llano C. T., Arnau M. A., Bel A., Blanes M., Osa A., Anguita M., Carrasco F., Castillo J., Zamorano J. L., Mur J. L. M., Alvaro M., Fernandez-Golfin C., Monteagudo J. M., Elorza E. N., Alvarez M. C. F., Balbin J. A., Arminanzas C., de las Revillas F. A., Garcia A. A., Belaustegui M. C., Sampedro M. F., Cuadra M. G., Gutierrez-Diez J. F., Zarauza J., Cuello L. G., Rico C. G., Rodriguez-Alvarez R., Goikoetxea J., Montejo M., Miro J., Almela M., Ambrosioni J., Falces C., Fuster D., Garcia-de-la-Maria C., Hernandez-Meneses M., Llopis J., Marco F., Moreno A., Quintana E., Sandoval E., Tellez A., Tolosana J. M., Vidal B., Ruiz-Zamora I., Ruiz A. B., Girgas E. S., Garcia-Pardo G., Marzo M. G., Oviedo A. R., Jimenez A. V., Abid L., Hammami R., Kammoun S., Mourali M. S., Zghal F. M., Hlima M. B., Boudiche S., Ouali S., Zakhama L., Antit S., Slama I., Gulel O., Sahin M., Sade L. E., Karacaglar E., Kucukoglu S., Cetinarslan O., Yasar U. S., Canpolat U., Atas H., Dervishova R., Ileri C., Zaky H., Alhashmi J., Baslib F., Tahir J., Zarger P., Woldman S., Menezes L., Primus C., Uppal R., Bvekerwa I., Chandrasekaran B., Kopanska A., Prendergast B., Cannata S., Chambers J., Hancock J., Klein J., Rajani R., Ursi M. P., Dworakowski R., Fife A., Breeze J., Browne-Morgan M., Gunning M., Streather S., Asch F., Zemedkun M., Alyavi B., and Uzokov J.
Abstract: Purpose: High mortality and a limited performance of valvular surgery are typical features of infective endocarditis (IE) in octogenarians, even though surgical treatment is a major determinant of a successful outcome in IE. Methods: Data from the prospective multicentre ESC EORP EURO-ENDO registry were used to assess the prognostic role of valvular surgery depending on age. Results: As compared to < 80 yo patients, ≥ 80 yo had lower rates of theoretical indication for valvular surgery (49.1% vs. 60.3%, p < 0.001), of surgery performed (37.0% vs. 75.5%, p < 0.001), and a higher in-hospital (25.9% vs. 15.8%, p < 0.001) and 1-year mortality (41.3% vs. 22.2%, p < 0.001). By multivariable analysis, age per se was not predictive of 1-year mortality, but lack of surgical procedures when indicated was strongly predictive (HR 2.98 [2.43–3.66]). By propensity analysis, 304 ≥ 80 yo were matched to 608 < 80 yo patients. Propensity analysis confirmed the lower rate of indication for valvular surgery (51.3% vs. 57.2%, p = 0.031) and of surgery performed (35.3% vs. 68.4%, p < 0.0001) in ≥ 80 yo. Overall mortality remained higher in ≥ 80 yo (in-hospital: HR 1.50[1.06–2.13], p = 0.0210; 1-yr: HR 1.58[1.21–2.05], p = 0.0006), but was not different from that of < 80 yo among those who had surgery (in-hospital: 19.7% vs. 20.0%, p = 0.4236; 1-year: 27.3% vs. 25.5%, p = 0.7176). Conclusion: Although mortality rates are consistently higher in ≥ 80 yo patients than in < 80 yo patients in the general population, mortality of surgery in ≥ 80 yo is similar to < 80 yo after matching patients. These results confirm the importance of a better recognition of surgical indication and of an increased performance of surgery in ≥ 80 yo patients.
Published: 2022

74. Identification and expression pattern analysis of the glucosinolate biosynthetic gene BoCYP83B1 from broccoli

Author: Xu, R., Kong, W. W., Peng, Y. F., Zhang, K. X., Li, R., and Li, J.
Published: 2018
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75. Performance of windshear/microburst detection algorithms using numerical weather prediction model data for selected tropical cyclone cases

Author: Chan, P. W., primary, Lai, K. K., additional, Kong, W., additional, and Tse, S. M., additional
Published: 2023
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76. OC-0287 Fast and fully-automated robust multi-criterial IMPT planning via sparsity induced spot selection

Author: Kong, W., primary, Oud, M., additional, Habraken, S., additional, Huiskes, M., additional, Astreinidou, E., additional, Rasch, C., additional, Heijmen, B., additional, and Breedveld, S., additional
Published: 2023
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77. Immunotherapy: AUTOLOGOUS ELIXIR MULTICELLULAR IMMUNE THERAPY (EMIT) IS FEASIBLE, SAFE AND POTENTIALLY BENEFICIAL FOR ADVANCED GASTROINTESTINAL CANCERS IN CLINICAL CASE SERIES

Author: Chin, S., primary, Tai, L., additional, Kong, W., additional, and Cheong, S., additional
Published: 2023
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78. OC-0285 Fully automated robust multi-criterial treatment planning for HNC IMPT

Author: Huiskes, M., primary, Kong, W., additional, Astreinidou, E., additional, Crama, K., additional, Breedveld, S., additional, Heijmen, B., additional, and Rasch, C., additional
Published: 2023
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79. Simulation of parametric decay instability excited by oscillating pump near lower hybrid frequency

Author: Kong, W., primary, Wang, X. Y., additional, Lin, Y., additional, and Chen, L., additional
Published: 2023
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80. Airway Epithelial Circular RNA Expression Is Altered in Asthma

Author: Huang, C., primary, Chen, D., additional, Gao, J., additional, Zhao, L., additional, Chen, G., additional, Kong, W., additional, Wu, W., additional, Feng, Y., additional, Yi, L., additional, and Zhen, G., additional
Published: 2023
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81. DWI-Based Radiomics Predicts the Functional Outcome of Endovascular Treatment in Acute Basilar Artery Occlusion

Author: Zhang, X., primary, Miao, J., additional, Yang, J., additional, Liu, C., additional, Huang, J., additional, Song, J., additional, Xie, D., additional, Yue, C., additional, Kong, W., additional, Hu, J., additional, Luo, W., additional, Liu, S., additional, Li, F., additional, and Zi, W., additional
Published: 2023
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82. Data from Autophagy Governs Protumorigenic Effects of Mitotic Slippage–induced Senescence

Author: Jakhar, Rekha, primary, Luijten, Monique N.H., primary, Wong, Alex X.F., primary, Cheng, Bing, primary, Guo, Ke, primary, Neo, Suat P., primary, Au, Bijin, primary, Kulkarni, Madhura, primary, Lim, Kah J., primary, Maimaiti, Jiamila, primary, Chong, Han C., primary, Lim, Elaine H., primary, Tan, Tee B.K., primary, Ong, Kong W., primary, Sim, Yirong, primary, Wong, Jill S.L., primary, Khoo, James B.K., primary, Ho, Juliana T.S., primary, Chua, Boon T., primary, Sinha, Indrajit, primary, Wang, Xiaomeng, primary, Connolly, John E., primary, Gunaratne, Jayantha, primary, and Crasta, Karen C., primary
Published: 2023
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83. Supplementary Data containing Supplementary Methods, 10 Supplementary Figures and 5 Supplementary Tables from Autophagy Governs Protumorigenic Effects of Mitotic Slippage–induced Senescence

Author: Jakhar, Rekha, primary, Luijten, Monique N.H., primary, Wong, Alex X.F., primary, Cheng, Bing, primary, Guo, Ke, primary, Neo, Suat P., primary, Au, Bijin, primary, Kulkarni, Madhura, primary, Lim, Kah J., primary, Maimaiti, Jiamila, primary, Chong, Han C., primary, Lim, Elaine H., primary, Tan, Tee B.K., primary, Ong, Kong W., primary, Sim, Yirong, primary, Wong, Jill S.L., primary, Khoo, James B.K., primary, Ho, Juliana T.S., primary, Chua, Boon T., primary, Sinha, Indrajit, primary, Wang, Xiaomeng, primary, Connolly, John E., primary, Gunaratne, Jayantha, primary, and Crasta, Karen C., primary
Published: 2023
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84. Effects of fulvic acids on gut barrier, microbial composition, fecal ammonia emission, and growth performance in broiler chickens

Author: Tang, C., primary, Kong, W., additional, Wang, H., additional, Liu, H., additional, Shi, L., additional, Uyanga, V.A., additional, Zhao, J., additional, Wang, X., additional, Lin, H., additional, and Jiao, H., additional
Published: 2023
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85. Effects of fulvic acids on gut barrier, microbial composition, fecal ammonia emission, and growth performance in broiler chickens

Author: Tang, C., Kong, W., Wang, H., Liu, H., Shi, L., Uyanga, V.A., Zhao, J., Wang, X., Lin, H., Jiao, H., Tang, C., Kong, W., Wang, H., Liu, H., Shi, L., Uyanga, V.A., Zhao, J., Wang, X., Lin, H., and Jiao, H.
Abstract: This study investigated the effects of fulvic acid (FA) on the growth performance, intestinal function, and fecal ammonia excretion of broilers. A total of 480 1-day-old male broilers were randomly divided into 4 treatments: control (CON) treatment, and the treatment on a basal diet supplemented with 0.15, 0.3, or 0.5% FA. The addition of 0.5% FA increased the feed-to-gain ratio and average daily feed intake during the first 7 d of the experiment, whereas, 0.3% FA addition increased the feed-to-gain ratio at 15 to 21 d, but FA addition had no effect on growth performance at other times. Compared to the CON treatment, 0.5% FA addition increased the serum IgA content, amylase, and lipase activities in the jejunum, as well as the lipase activity and mucin 2 content in the ileum. Feeding broilers with 0.15% FA increased the occludin and zonula occluden-1 content in the ileum, elevated intestinal permeability markers such as diamine oxidase, lipopolysaccharide, and D-lactate dehydrogenase, and further enriched functional pathways including nitrogen metabolism and riboflavin metabolism. Also, FA addition (0.15, 0.3, or 0.5%) increased the jejunum mucin 2 content and maintained the relative stability of the cecal microbiota without detrimental changes to the microbiota composition. Importantly, FA addition decreased the fecal ammonia yield on 2, 4, and 5 d of the fecal ammonia determination in a dose-dependent manner and also lowered the urease activity on 1 and 3 d. Therefore, the addition of 0.15% FA was considered the most effective in maintaining the intestinal health and microbial composition of broilers.
Published: 2023

86. Contribution of Somatic Ras/Raf/Mitogen-Activated Protein Kinase Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy

Author: Khoshkhoo, S, Wang, Y, Chahine, Y, Erson-Omay, EZ, Robert, SM, Kiziltug, E, Damisah, EC, Nelson-Williams, C, Zhu, G, Kong, W, Huang, AY, Stronge, E, Phillips, HW, Chhouk, BH, Bizzotto, S, Chen, MH, Adikari, TN, Ye, Z, Witkowski, T, Lai, D, Lee, N, Lokan, J, Scheffer, IE, Berkovic, SF, Haider, S, Hildebrand, MS, Yang, E, Gunel, M, Lifton, RP, Richardson, RM, Bluemcke, I, Alexandrescu, S, Huttner, A, Heinzen, EL, Zhu, J, Poduri, A, DeLanerolle, N, Spencer, DD, Lee, EA, Walsh, CA, Kahle, KT, Khoshkhoo, S, Wang, Y, Chahine, Y, Erson-Omay, EZ, Robert, SM, Kiziltug, E, Damisah, EC, Nelson-Williams, C, Zhu, G, Kong, W, Huang, AY, Stronge, E, Phillips, HW, Chhouk, BH, Bizzotto, S, Chen, MH, Adikari, TN, Ye, Z, Witkowski, T, Lai, D, Lee, N, Lokan, J, Scheffer, IE, Berkovic, SF, Haider, S, Hildebrand, MS, Yang, E, Gunel, M, Lifton, RP, Richardson, RM, Bluemcke, I, Alexandrescu, S, Huttner, A, Heinzen, EL, Zhu, J, Poduri, A, DeLanerolle, N, Spencer, DD, Lee, EA, Walsh, CA, and Kahle, KT
Abstract: IMPORTANCE: Mesial temporal lobe epilepsy (MTLE) is the most common focal epilepsy subtype and is often refractory to antiseizure medications. While most patients with MTLE do not have pathogenic germline genetic variants, the contribution of postzygotic (ie, somatic) variants in the brain is unknown. OBJECTIVE: To test the association between pathogenic somatic variants in the hippocampus and MTLE. DESIGN, SETTING, AND PARTICIPANTS: This case-control genetic association study analyzed the DNA derived from hippocampal tissue of neurosurgically treated patients with MTLE and age-matched and sex-matched neurotypical controls. Participants treated at level 4 epilepsy centers were enrolled from 1988 through 2019, and clinical data were collected retrospectively. Whole-exome and gene-panel sequencing (each genomic region sequenced more than 500 times on average) were used to identify candidate pathogenic somatic variants. A subset of novel variants was functionally evaluated using cellular and molecular assays. Patients with nonlesional and lesional (mesial temporal sclerosis, focal cortical dysplasia, and low-grade epilepsy-associated tumors) drug-resistant MTLE who underwent anterior medial temporal lobectomy were eligible. All patients with available frozen tissue and appropriate consents were included. Control brain tissue was obtained from neurotypical donors at brain banks. Data were analyzed from June 2020 to August 2022. EXPOSURES: Drug-resistant MTLE. MAIN OUTCOMES AND MEASURES: Presence and abundance of pathogenic somatic variants in the hippocampus vs the unaffected temporal neocortex. RESULTS: Of 105 included patients with MTLE, 53 (50.5%) were female, and the median (IQR) age was 32 (26-44) years; of 30 neurotypical controls, 11 (36.7%) were female, and the median (IQR) age was 37 (18-53) years. Eleven pathogenic somatic variants enriched in the hippocampus relative to the unaffected temporal neocortex (median [IQR] variant allele frequency, 1.92 [1.5-2.7] v
Published: 2023

87. ProJect: a powerful mixed-model missing value imputation method.

Author: Kong, W, Wong, BJH, Hui, HWH, Lim, KP, Wang, Y, Wong, L, Goh, WWB, Kong, W, Wong, BJH, Hui, HWH, Lim, KP, Wang, Y, Wong, L, and Goh, WWB
Abstract: Missing values (MVs) can adversely impact data analysis and machine-learning model development. We propose a novel mixed-model method for missing value imputation (MVI). This method, ProJect (short for Protein inJection), is a powerful and meaningful improvement over existing MVI methods such as Bayesian principal component analysis (PCA), probabilistic PCA, local least squares and quantile regression imputation of left-censored data. We rigorously tested ProJect on various high-throughput data types, including genomics and mass spectrometry (MS)-based proteomics. Specifically, we utilized renal cancer (RC) data acquired using DIA-SWATH, ovarian cancer (OC) data acquired using DIA-MS, bladder (BladderBatch) and glioblastoma (GBM) microarray gene expression dataset. Our results demonstrate that ProJect consistently performs better than other referenced MVI methods. It achieves the lowest normalized root mean square error (on average, scoring 45.92% less error in RC_C, 27.37% in RC_full, 29.22% in OC, 23.65% in BladderBatch and 20.20% in GBM relative to the closest competing method) and the Procrustes sum of squared error (Procrustes SS) (exhibits 79.71% less error in RC_C, 38.36% in RC full, 18.13% in OC, 74.74% in BladderBatch and 30.79% in GBM compared to the next best method). ProJect also leads with the highest correlation coefficient among all types of MV combinations (0.64% higher in RC_C, 0.24% in RC full, 0.55% in OC, 0.39% in BladderBatch and 0.27% in GBM versus the second-best performing method). ProJect's key strength is its ability to handle different types of MVs commonly found in real-world data. Unlike most MVI methods that are designed to handle only one type of MV, ProJect employs a decision-making algorithm that first determines if an MV is missing at random or missing not at random. It then employs targeted imputation strategies for each MV type, resulting in more accurate and reliable imputation outcomes. An R implementation of ProJect is availabl
Published: 2023

88. Erratum: Outcomes of culture-negative vs. culture-positive infective endocarditis: the ESC-EORP EURO-ENDO registry ( European Heart Journal (2022) 43: 29 (2770–2780) DOI: 10.1093/eurheartj/ehac307)

Author: Kong, WKF, Kong, W, Salsano, A, Giacobbe, D, Popescu, B, Laroche, C, Duval, X, Schueler, R, Moreo, A, Colonna, P, Piper, C, Calvo-Iglesias, F, Badano, L, Srdanovic, I, Boutoile, D, Huttin, O, Stöhr, E, Timóteo, A, Vaskelyte, J, Sadeghpour, A, Tornos, P, Abid, L, Poh, K, Habib, G, Lacellotti, P, Kong, WKF, Giacobbe, DR, Popescu, BA, Timóteo, AT, Vaskelyte, JJ, Poh, KK, Kong, WKF, Kong, W, Salsano, A, Giacobbe, D, Popescu, B, Laroche, C, Duval, X, Schueler, R, Moreo, A, Colonna, P, Piper, C, Calvo-Iglesias, F, Badano, L, Srdanovic, I, Boutoile, D, Huttin, O, Stöhr, E, Timóteo, A, Vaskelyte, J, Sadeghpour, A, Tornos, P, Abid, L, Poh, K, Habib, G, Lacellotti, P, Kong, WKF, Giacobbe, DR, Popescu, BA, Timóteo, AT, Vaskelyte, JJ, and Poh, KK
Abstract: This is a corrigendum to: William K F Kong, Antonio Salsano, Daniele Roberto Giacobbe, Bogdan A Popescu, Cécile Laroche, Xavier Duval, Robert Schueler, Antonella Moreo, Paolo Colonna, Cornelia Piper, Francisco Calvo-Iglesias, Luigi P Badano, Ilija Srdanovic, David Boutoille, Olivier Huttin, Elisabeth Stöhr, Ana Teresa Timóteo, Jolanta Justina Vaskelyte, Anita Sadeghpour, Pilar Tornos, Leila Abid, Kian Keong Poh, Gilbert Habib, Patrizio Lancellotti, on behalf of the EURO-ENDO Investigators, Outcomes of culture-negative vs. culture-positive infective endocarditis: the ESC-EORP EURO-ENDO registry, European Heart Journal, Volume 43, Issue 29, 1 August 2022, Pages 2770–2780, https://doi.org/10.1093/eurheartj/ehac307 In the originally published version, named members of the EURO-ENDO Investigators were mistakenly included in the supplementary data section, rather than the main body of the manuscript. This has now been corrected online.
Published: 2023

89. A variable damping vibration energy harvester based on Half-Wave flywheeling effect for freight railways

Author: Zhang, Tingshen, Cao, H., Zhang, Z., Kong, W., Kong, L., Liu, J., Yan, Jinyue, Zhang, Tingshen, Cao, H., Zhang, Z., Kong, W., Kong, L., Liu, J., and Yan, Jinyue
Abstract: The vibrational energy, often considered a negative factor, is abundant in everyday life. Especially in railway systems, the negatively impacted track vibrations resulting from moving trains can be captured to provide a practical power supply solution for wireless sensor networks. This paper proposed a variable damping vibration energy harvester with a half-wave flywheel for a freight train-based railway. A double-sided rack as the input member converts the track vibration into the opposite rotation of the two pinions, which are then transmitted to the two parallel shafts respectively. According to the work characteristics of the one-way bearing, the upper and lower vibrations can be collected separately and output a one-way rotation to the generator module. The proposed harvester with a half-wave flywheel features a larger damping force for vibration reduction during the downward track vibration and a smaller damping force conducive to returning the track's original state during the upward track vibration. The experimental results achieve a maximum output power of 10.247 W and a maximum mechanical efficiency of 74.49%. Both simulations and experiments have verified that the proposed system with a half-wave flywheel can increase the damping force in the vibration reduction process and reduce the damping force in the reset process, which is characteristic of improving its power generation performance with a good vibration reduction effect. The VEH with the half-wave flywheel achieved an average power of 5.321 W at the train speed of 90 km/h under random vibration testing, which verifies the feasibility of self-powered wireless sensor networks in railway environments.
Published: 2023
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90. Evaluating network-based missing protein prediction using p-values, Bayes Factors, and probabilities.

Author: Goh, WWB, Kong, W, Wong, L, Goh, WWB, Kong, W, and Wong, L
Abstract: Some prediction methods use probability to rank their predictions, while some other prediction methods do not rank their predictions and instead use [Formula: see text]-values to support their predictions. This disparity renders direct cross-comparison of these two kinds of methods difficult. In particular, approaches such as the Bayes Factor upper Bound (BFB) for [Formula: see text]-value conversion may not make correct assumptions for this kind of cross-comparisons. Here, using a well-established case study on renal cancer proteomics and in the context of missing protein prediction, we demonstrate how to compare these two kinds of prediction methods using two different strategies. The first strategy is based on false discovery rate (FDR) estimation, which does not make the same naïve assumptions as BFB conversions. The second strategy is a powerful approach which we colloquially call "home ground testing". Both strategies perform better than BFB conversions. Thus, we recommend comparing prediction methods by standardization to a common performance benchmark such as a global FDR. And where this is not possible, we recommend reciprocal "home ground testing".
Published: 2023

91. Data from Autophagy Governs Protumorigenic Effects of Mitotic Slippage–induced Senescence

Author: Karen C. Crasta, Jayantha Gunaratne, John E. Connolly, Xiaomeng Wang, Indrajit Sinha, Boon T. Chua, Juliana T.S. Ho, James B.K. Khoo, Jill S.L. Wong, Yirong Sim, Kong W. Ong, Tee B.K. Tan, Elaine H. Lim, Han C. Chong, Jiamila Maimaiti, Kah J. Lim, Madhura Kulkarni, Bijin Au, Suat P. Neo, Ke Guo, Bing Cheng, Alex X.F. Wong, Monique N.H. Luijten, and Rekha Jakhar
Abstract: The most commonly utilized class of chemotherapeutic agents administered as a first-line therapy are antimitotic drugs; however, their clinical success is often impeded by chemoresistance and disease relapse. Hence, a better understanding of the cellular pathways underlying escape from cell death is critical. Mitotic slippage describes the cellular process where cells exit antimitotic drug-enforced mitotic arrest and “slip” into interphase without proper chromosome segregation and cytokinesis. The current report explores the cell fate consequence following mitotic slippage and assesses a major outcome following treatment with many chemotherapies, therapy-induced senescence. It was found that cells postslippage entered senescence and could impart the senescence-associated secretory phenotype (SASP). SASP factor production elicited paracrine protumorigenic effects, such as migration, invasion, and vascularization. Both senescence and SASP factor development were found to be dependent on autophagy. Autophagy induction during mitotic slippage involved the autophagy activator AMPK and endoplasmic reticulum stress response protein PERK. Pharmacologic inhibition of autophagy or silencing of autophagy-related ATG5 led to a bypass of G1 arrest senescence, reduced SASP-associated paracrine tumorigenic effects, and increased DNA damage after S-phase entry with a concomitant increase in apoptosis. Consistent with this, the autophagy inhibitor chloroquine and microtubule-stabilizing drug paclitaxel synergistically inhibited tumor growth in mice. Sensitivity to this combinatorial treatment was dependent on p53 status, an important factor to consider before treatment.Implications: Clinical regimens targeting senescence and SASP could provide a potential effective combinatorial strategy with antimitotic drugs. Mol Cancer Res; 16(11); 1625–40. ©2018 AACR.
Published: 2023

92. Supplementary Data containing Supplementary Methods, 10 Supplementary Figures and 5 Supplementary Tables from Autophagy Governs Protumorigenic Effects of Mitotic Slippage–induced Senescence

Author: Karen C. Crasta, Jayantha Gunaratne, John E. Connolly, Xiaomeng Wang, Indrajit Sinha, Boon T. Chua, Juliana T.S. Ho, James B.K. Khoo, Jill S.L. Wong, Yirong Sim, Kong W. Ong, Tee B.K. Tan, Elaine H. Lim, Han C. Chong, Jiamila Maimaiti, Kah J. Lim, Madhura Kulkarni, Bijin Au, Suat P. Neo, Ke Guo, Bing Cheng, Alex X.F. Wong, Monique N.H. Luijten, and Rekha Jakhar
Abstract: S1. Post-slippage cells arrest at G1 as tetraploid multinucleated cells. S2. Correlation of multinucleation and senescence post-slippage in response to various anti-mitotic drugs. S3. In vivo association of senescence and anti-mitotic drug treatment. S4. Post-slippage cells increase expression of factors associated with senescence and SASP. S5. SASP factors from post-slippage cells do not affect proliferation of neighbouring cells. S6. Autophagy mediates senescence. S7. Autophagy does not modulate cell fate during prolonged mitotic arrest. S8. Autophagy-dependent IL-1β and IL-8 expression mediate cell invasiveness in a paracrine manner. S9. Silencing of p53 increases post-slippage cell death. S10. p53 status determines synergistic effect of microtubule poisons and autophagy inhibition. Table S1. List of differentially regulated proteins after 48 h Noc treatment detected by SILAC mass spectrometry. Table S2. List of antibodies. Table S3. List of chemicals. Table S4. List of primers. Table S5. Quantitative H scoring method
Published: 2023

93. Photoadaptation to the polar night by phytoplankton in a permanently ice-covered Antarctic lake

Author: Morgan-Kiss, R. M., Lizotte, M. P., Kong, W., and Priscu, J. C.
Published: 2016

94. Association of Resting Heart Rate with Infrarenal Aortic Diameter: A Cross Sectional Study in Chinese Hypertensive Adults

Author: Wei, R., Liu, L.S., Wang, L.W., Li, Y.B., Zhang, T., Liu, J., Zuo, S.W., Jia, S.H., Song, Y.X., Wu, Z.Y., Duan, C., Ge, Y.Y., Li, H.B., Xiong, J., Jia, X., Wang, X., Kong, W., Xu, X.P., Guo, W., and Huo, Y.
Published: 2015
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95. The ESC-EORP EURO-ENDO (European Infective Endocarditis) registry

Author: Habib G., Lancellotti P., Erba P. -A., Sadeghpour A., Meshaal M., Sambola A., Furnaz S., Citro R., Ternacle J., Donal E., Cosyns B., Popescu B., Iung B., Prendergast B., Laroche C., Tornos P., Pazdernik M., Maggioni A., Gale C. P., Ali Tatar-Chentir N. N., Al-Mallah M., Astrom Aneq M., Athanassopoulos G., Badano L, Benyoussef S., Calderon Aranda E., Cardim N. M., Chan K. -L., Cruz I., Edvardsen T., Goliasch G., Hagendorff A., Hristova K., Kamp O., Kang D. -H., Kong W., Matskeplishvili S., Mirocevic M., Neskovic A. N., Plonska-Gosciniak E., Popescu B. A., Raissouni M., Ronderos R., Sade L. E., Sengupta S., Separovic-Hanzevacki J., Takeuchi M., Tucay E., Tude Rodrigues A. C., Varga A., Vaskelyte J., Yamagata K., Yiangou K., Zaky H., Granada I., Mahia M., Ressi S., Nacinovich F., Iribarren A., Fernandez Oses P., Avegliano G., Filipini E., Obregon R., Bangher M., Dho J., Cartasegna L., Plastino M. L., Novas V., Shigel C., Reyes G., De Santos M., Gastaldello N., Granillo Fernandez M., Potito M., Streitenberger G., Velazco P., Casabe J. H., Cortes C., Guevara E., Salmo F., Seijo M., Weidinger F., Heger M., Brooks R., Stollberger C., Ho C. -Y., Perschy L., Puskas L., Binder C., Rosenhek R., Schneider M., Winter M. -P., Hoffer E., Melissopoulou M., Lecoq E., Legrand D., Jacquet S., Massoz M., Pierard L., Marchetta S., Dulgheru R., Emal C. D., Oury C., Droogmans S., Kerkhove D., Plein D., Soens L., Weytjens C., Motoc A., Roosens B., Lemoine I., Rodrigus I., Paelinck B., Amsel B., Unger P., Konopnicki D., Beauloye C., Pasquet A., Vanoverschelde J. L., Pierard S., Vancraeynest D., Sinnaeve F., Andrade J. L., Staszko K., Dos Santos Monteiro R., Miglioranza M. H., Shuha D. L., Alcantara M., Cravo V., Fazzio L., Felix A., Iso M., Musa C., Siciliano A. P., Villaca Filho F., Rodrigues A., Vilela F., Braga J., Silva R., Rodrigues D., Silva L., Morhy S., Fischer C., Vieira M., Afonso T., Abreu J., Falcao S. N., Moises V. A., Gouvea A., Mancuso F. J., Souza A. C., Silva C. Y., Joao G., Abboud C. S., Bellio De Mattos Barretto R., Ramos A., Arnoni R., Assef J. E., Della Togna D. J., Bihan D. L., Miglioli L., Romero Oliveira A. P., Tadeu Magro Kroll R., Cortez D., Gelape C. L., Peirira Nunes M. D. C., De Abreu Ferrari T. C., Hay K., Le V., Page M., Poulin F., Sauve C., Serri K., Mercure C., Beaudoin J., Pibarot P., Sebag I. A., Rudski L. G., Ricafort G., Barsic B., Krajinovic V., Vargovic M., Lovric D., Reskovic-Luksic V., Vincelj J., Jaksic Jurinjak S., Yiannikourides V., Ioannides M., Pofaides C., Masoura V., Pudich J., Linhart A., Siranec M., Marek J., Blechova K., Kamenik M., Pelouch R., Coufal Z., Mikulica M., Griva M., Jancova E., Mikulcova M., Taborsky M., Precek J., Jecmenova M., Latal J., Widimsky J., Butta T., MacHacek S., Vancata R., Spinar J., Holicka M., Pow Chon Long F., Anzules N., Bajana Carpio A., Largacha G., Penaherrera E., Moreira D., Mahfouz E., Elsafty E., Soliman A., Zayed Y., Aboulenein J., Abdel-Hay M., Almaghraby A., Abdelnaby M., Ahmed M., Hammad B., Saleh Y., Zahran H., Elgebaly O., Saad A., Ali M., Zeid A., El Sharkawy R., Al Kholy A., Doss R., Osama D., Rizk H., Elmogy A., Mishriky M., Assayag P., El Hatimi S., Hubert S., Casalta J. -P., Gouriet F., Arregle F., Cammilleri S., Tessonnier L., Riberi A., Botelho-Nevers E., Gagneux-Brunon A., Pierrard R., Tulane C., Campisi S., Fuzellier J. -F., Detoc M., Mehalla T., Boutoille D., Lecompte A. S., Lefebvre M., Pattier S., Al Habash O., Asseray-Madani N., Biron C., Brochard J., Caillon J., Cueff C., Tourneau T. L., Lecomte R., Magali Michel M. M., Orain J., Delarue S., Bras M. L., Faucher J. -F., Aboyans V., Beeharry A., Durox H., Lacoste M., Magne J., Mohty D., David A., Pradel V., Sierra V., Neykova A., Bettayeb B., Elkentaoui S., Tzvetkov B., Landry G., Strady C., Ainine K., Baumard S., Brasselet C., Tassigny C., Valente-Pires V., Lefranc M., Hoen B., Lefevre B., Curlier E., Callier C., Fourcade N., Jobic Y., Ansard S., Berre R. L., Ven F. L., Pouliquen M. -C., Prat G., Roux P. L., Bouchart F., Savoure A., Alarcon C., Chapuzet C., Gueit I., Tribouilloy C., Bohbot Y., Peugnet F., Gun M., Duval X., Lescure X., Ilic-Habensus E., Sadoul N., Selton-Suty C., Alla F., Goehringer F., Huttin O., Chevalier E., Garcia R., Marcis V. L., Tattevin P., Flecher E., Revest M., Chirouze C., Bouiller K., Hustache-Mathieu L., Klopfenstein T., Moreau J., Fournier D., Brunel A. -S., Lim P., Oliver L., Moussafeur A., Chavanet P., Piroth L., Salmon-Rousseau A., Buisson M., Mahy S., Martins C., Gohier S., Axler O., Baumann F., Lebras S., Piper C., Guckel D., Borgermann J., Horstkotte D., Winkelmann E., Brockmeier B., Grey D., Nickenig G., Schueler R., Ozturk C., Stohr E., Hamm C., Walther T., Brandt R., Fruhauf A. -C., Hartung C. T., Hellner C., Wild C., Becker M., Hamada S., Kaestner W., Stangl K., Knebel F., Baldenhofer G., Brecht A., Dreger H., Isner C., Pfafflin F., Stegemann M., Zahn R., Fraiture B., Kilkowski C., Karcher A. -K., Klinger S., Tolksdorf H., Tousoulis D., Aggeli C., Sideris S., Venieri E., Sarri G., Tsiapras D., Armenis I., Koutsiari A., Floros G., Grassos C., Dragasis S., Rallidis L., Varlamos C., Michalis L., Naka K., Bechlioulis A., Kotsia A., Lakkas L., Pappas K., Papadopoulos C., Kiokas S., Lioni A., Misailidou S., Barbetseas J., Bonou M., Kapelios C., Tomprou I., Zerva K., Manolis A., Hamodraka E., Athanasiou D., Haralambidis G., Samaras H., Poulimenos L., Nagy A., Bartykowszki A., Gara E., Mungulmare K., Kasliwal R., Bansal M., Ranjan S., Bhan A., Kyavar M., Maleki M., Noohi Bezanjani F., Alizadehasl A., Boudagh S., Ghavidel A., Moradnejad P., Pasha H. R., Ghadrdoost B., Gilon D., Strahilevitz J., Wanounou M., Israel S., D'Agostino C., Colonna P., Michele L. D., Fumarola F., Stante M., Marchionni N., Scheggi V., Alterini B., Del Pace S., Stefano P., Sparano C., Ruozi N., Tenaglia R., Muraru D., Limbruno U., Cresti A., Baratta P., Solari M., Giannattasio C., Moreo A., Chiara B. D., Lopez Montero B., Musca F., Orcese C. A., Panzeri F., Spano F., Russo C. F., Alfieri O., Bonis M. D., Chiappetta S., Del Forno B., Ripa M., Scarpellini P., Tassan Din C., Castiglioni B., Pasciuta R., Carletti S., Ferrara D., Guffanti M., Iaci G., Lapenna E., Nisi T., Oltolini C., Busnardo E., Pajoro U., Agricola E., Meneghin R., Schiavi D., Piscione F., Benvenga R. M., Greco L., Soriente L., Radano I., Prota C., Bellino M., Vece D. D., Santini F., Salsano A., Olivieri G. M., Turrini F., Messora R., Tondi S., Olaru A., Agnoletto V., Grassi L., Leonardi C., Sansoni S., Del Ponte S., Actis Dato G. M., Martino A. D., Ohte N., Kikuchi S., Wakami K., Aonuma K., Seo Y., Ishizu T., MacHino-Ohtsuka T., Yamamoto M., Iida N., Nakajima H., Nakagawa Y., Izumi C., Amano M., Miyake M., Takahashi K., Shiojima I., Miyasaka Y., Maeba H., Suwa Y., Taniguchi N., Tsujimoto S., Kitai T., Ota M., Yuda S., Sasaki S., Hagiwara N., Yamazaki K., Ashihara K., Arai K., Saitou C., Saitou S., Suzuki G., Shibata Y., Watanabe N., Nishino S., Ashikaga K., Kuriyama N., Mahara K., Okubo T., Fujimaki H., Shitan H., Yamamoto H., Abe K., Terada M., Takanashi S., Sata M., Yamada H., Kusunose K., Saijo Y., Seno H., Yuichiro O., Onishi T., Sera F., Nakatani S., Mizuno H., Sengoku K., Park S. W., Eun Kyoung K., Ga Yeon L., Hwang J. -W., Jin-Oh C., Park S. -J., Sang-Chol L., Sung-A C., Jang S. Y., Heo R., Lee S., Song J. -M., Jung E., Plisiene J., Dambrauskaite A., Gruodyte G., Jonkaitiene R., Mizariene V., Atkocaityte J., Zvirblyte R., Sow R., Codreanu A., Staub T., Michaux C., De La Vega E. C. L., Jacobs-Orazi L., Mallia Azzopardi C., Xuereb R. G., Piscopo T., Farrugia J., Fenech M., Pllaha E., Vella C., Borg D., Casha R., Grib L., Raevschi E., Grejdieru A., Kravcenco D., Prisacari E., Samohvalov E., Samohvalov S., Sceglova N., Panfile E., Cardaniuc L., Corcea V., Feodorovici A., Gaina V., Girbu L., Jimbei P., Balan G., Cardaniuc I., Benesco I., Marian V., Sumarga N., Bozovic B., Bulatovic N., Lakovic P., Music L., Budde R., Wahadat A., Gamela T., Meijers T., Van Melle J. P., Deursen V. M., Crijns H. J., Bekkers S. C., Cheriex E. C., Gilbers M., Kietselaer B. L., Knackstedt C., Lorusso R., Schalla S., Streukens S. A., Chamuleau S., Cramer M. -J., Teske A., Van Der Spoel T., Wind A., Lokhorst J., Liesbek O., Van Heusden H., Tanis W., Van Der Bilt I., Vriend J., Lange-Van Bruggen H. D., Karijodikoro E., Riezebos R., Van Dongen E., Schoep J., Stolk V., Offstad J. T., Beitnes J. O., Helle-Valle T., Skulstad H., Skardal R., Qamar N., Ahmed B., Butt M. H., Khanzada M. F., Saghir T., Wahid A., Hryniewiecki T., Szymanski P., Marzec K., Misztal-Ogonowska M., Kosmala W., Przewlocka-Kosmala M., Rojek A., Woznicka K., Zachwyc J., Lisowska A., Kaminska M., Kasprzak J. D., Kowalczyk E., Strzecka D. F., Wejner-Mik P., Trabulo M., Freitas P., Ranchordas S., Rodrigues G., Pinto P., Queiros C., Azevedo J., Marques L., Seabra D., Branco L., Cruz M., Galrinho A., Moreira R., Rio P., Timoteo A. T., Selas M., Carmelo V., Duque Neves B., Pereira H., Guerra A., Marques A., Pintassilgo I., Tomescu M. C., Trofenciuc N. -M., Andor M., Bordejevic A., Branea H. S., Caruntu F., Velcean L. A., Mavrea A., Onel M. F., Parvanescu T., Pop D., Pop-Moldovan A. L., Puticiu M. I., Cirin L., Citu I. M., Cotoraci C. A., Darabantiu D., Farcas R., Marincu I., Ionac A., Cozma D., Mornos C., Goanta F., Popescu I., Beyer R., Mada R., Rancea R., Tomoaia R., Rosianu H., Stanescu C., Kobalava Z., Karaulova J., Kotova E., Milto A., Pisaryuk A., Povalyaev N., Sorokina M., Alrahimi J., Elshiekh A., Jamiel A., Ahmed A., Attia N., Putnikovic B., Dimic A., Ivanovic B., Matic S., Trifunovic D., Petrovic J., Kosevic D., Stojanovic I., Petrovic I., Dabic P., Milojevic P., Srdanovic I., Susak S., Velicki L., Vulin A., Kovacevic M., Redzek A., Stefanovic M., Yeo T. C., Kong W. K. F., Poh K. K., Vilacosta I., Ferrera C., Olmos C., Abd El-Nasser M., Calvo Iglesias F., Blanco-Gonzalez E., Bravo Amaro M., Lopez-Rodriguez E., Lugo Adan J., Germinas A. N., Pazos-Lopez P., Pereira Loureiro M., Perez M. T., Raposeiras-Roubin S., Rasheed Yas S., Suarez-Varela M. -M., Vasallo Vidal F., Garcia-Dorado D., Fernandez-Hidalgo N., Gonzalez-Alujas T., Lozano J., Maisterra O., Pizzi N., Rios R., Bayes-Genis A., Pedro Botet L., Vallejo N., Llibre C., Mateu L., Nunez R., Quesada D., Berastegui E., Bosch Portell D., Aboal Vinas J., Albert Bertran X., Brugada Tarradellas R., Loma-Osorio Ricon P., Tiron De Llano C., Arnau M. A., Bel A., Blanes M., Osa A., Anguita M., Carrasco F., Castillo J. C., Zamorano J. L., Moya Mur J. L., Alvaro M., Fernandez-Golfin C., Monteagudo J. M., Navas Elorza E., Farinas Alvarez M. C., Aguero Balbin J., Zarauza J., Gutierrez-Diez J. F., Arminanzas C., Arnaiz De Las Revillas F., Arnaiz Garcia A., Cobo Belaustegui M., Fernandez Sampedro M., Gutierrez Cuadra M., Garcia Cuello L., Gonzalez Rico C., Rodriguez-Alvarez R., Goikoetxea J., Montejo M., Miro J. M., Almela M., Ambrosioni J., Moreno A., Quintana E., Sandoval E., Tellez A., Tolosana J. M., Vidal B., Falces C., Fuster D., Garcia-De-La-Maria C., Hernandez-Meneses M., Llopis J., Marco F., Ruiz-Zamora I., Bardaji Ruiz A., Sanz Girgas E., Garcia-Pardo G., Guillen Marzo M., Rodriguez Oviedo A., Villares Jimenez A., Abid L., Hammami R., Kammoun S., Mourali M. S., Ben Hlima M., Boudiche S., Ouali S., Zakhama L., Antit S., Slama I., Gulel O., Sahin M., Karacaglar E., Kucukoglu S., Cetinarslan O., Yasar U. S., Canpolat U., Mutlu B., Atas H., Dervishova R., Ileri C., Alhashmi J., Tahir J., Zarger P., Baslib F., Woldman S., Menezes L., Primus C., Uppal R., Bvekerwa I., Chandrasekaran B., Kopanska A., Chambers J., Hancock J., Klein J., Rajani R., Ursi M. P., Cannata S., Dworakowski R., Fife A., Breeze J., Browne-Morgan M., Gunning M., Streather S., Asch F. M., Zemedkun M., Alyavi B., Uzokov J., Cardiovascular Centre (CVC), Universidad de Cantabria, Habib, G, Lancellotti, P, Erba, P, Sadeghpour, A, Meshaal, M, Sambola, A, Furnaz, S, Citro, R, Ternacle, J, Donal, E, Cosyns, B, Popescu, B, Iung, B, Prendergast, B, Laroche, C, Tornos, P, Pazdernik, M, Maggioni, A, Gale, C, Ali Tatar-Chentir, N, Al-Mallah, M, Astrom Aneq, M, Athanassopoulos, G, Badano, L, Benyoussef, S, Calderon Aranda, E, Cardim, N, Chan, K, Cruz, I, Edvardsen, T, Goliasch, G, Hagendorff, A, Hristova, K, Kamp, O, Kang, D, Kong, W, Matskeplishvili, S, Mirocevic, M, Neskovic, A, Plonska-Gosciniak, E, Raissouni, M, Ronderos, R, Sade, L, Sengupta, S, Separovic-Hanzevacki, J, Takeuchi, M, Tucay, E, Tude Rodrigues, A, Varga, A, Vaskelyte, J, Yamagata, K, Yiangou, K, Zaky, H, Granada, I, Mahia, M, Ressi, S, Nacinovich, F, Iribarren, A, Fernandez Oses, P, Avegliano, G, Filipini, E, Obregon, R, Bangher, M, Dho, J, Cartasegna, L, Plastino, M, Novas, V, Shigel, C, Reyes, G, De Santos, M, Gastaldello, N, Granillo Fernandez, M, Potito, M, Streitenberger, G, Velazco, P, Casabe, J, Cortes, C, Guevara, E, Salmo, F, Seijo, M, Weidinger, F, Heger, M, Brooks, R, Stollberger, C, Ho, C, Perschy, L, Puskas, L, Binder, C, Rosenhek, R, Schneider, M, Winter, M, Hoffer, E, Melissopoulou, M, Lecoq, E, Legrand, D, Jacquet, S, Massoz, M, Pierard, L, Marchetta, S, Dulgheru, R, Emal, C, Oury, C, Droogmans, S, Kerkhove, D, Plein, D, Soens, L, Weytjens, C, Motoc, A, Roosens, B, Lemoine, I, Rodrigus, I, Paelinck, B, Amsel, B, Unger, P, Konopnicki, D, Beauloye, C, Pasquet, A, Vanoverschelde, J, Pierard, S, Vancraeynest, D, Sinnaeve, F, Andrade, J, Staszko, K, Dos Santos Monteiro, R, Miglioranza, M, Shuha, D, Alcantara, M, Cravo, V, Fazzio, L, Felix, A, Iso, M, Musa, C, Siciliano, A, Villaca Filho, F, Rodrigues, A, Vilela, F, Braga, J, Silva, R, Rodrigues, D, Silva, L, Morhy, S, Fischer, C, Vieira, M, Afonso, T, Abreu, J, Falcao, S, Moises, V, Gouvea, A, Mancuso, F, Souza, A, Silva, C, Joao, G, Abboud, C, Bellio De Mattos Barretto, R, Ramos, A, Arnoni, R, Assef, J, Della Togna, D, Bihan, D, Miglioli, L, Romero Oliveira, A, Tadeu Magro Kroll, R, Cortez, D, Gelape, C, Peirira Nunes, M, De Abreu Ferrari, T, Hay, K, Le, V, Page, M, Poulin, F, Sauve, C, Serri, K, Mercure, C, Beaudoin, J, Pibarot, P, Sebag, I, Rudski, L, Ricafort, G, Barsic, B, Krajinovic, V, Vargovic, M, Lovric, D, Reskovic-Luksic, V, Vincelj, J, Jaksic Jurinjak, S, Yiannikourides, V, Ioannides, M, Pofaides, C, Masoura, V, Pudich, J, Linhart, A, Siranec, M, Marek, J, Blechova, K, Kamenik, M, Pelouch, R, Coufal, Z, Mikulica, M, Griva, M, Jancova, E, Mikulcova, M, Taborsky, M, Precek, J, Jecmenova, M, Latal, J, Widimsky, J, Butta, T, Machacek, S, Vancata, R, Spinar, J, Holicka, M, Pow Chon Long, F, Anzules, N, Bajana Carpio, A, Largacha, G, Penaherrera, E, Moreira, D, Mahfouz, E, Elsafty, E, Soliman, A, Zayed, Y, Aboulenein, J, Abdel-Hay, M, Almaghraby, A, Abdelnaby, M, Ahmed, M, Hammad, B, Saleh, Y, 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C, Gueit, I, Tribouilloy, C, Bohbot, Y, Peugnet, F, Gun, M, Duval, X, Lescure, X, Ilic-Habensus, E, Sadoul, N, Selton-Suty, C, Alla, F, Goehringer, F, Huttin, O, Chevalier, E, Garcia, R, Marcis, V, Tattevin, P, Flecher, E, Revest, M, Chirouze, C, Bouiller, K, Hustache-Mathieu, L, Klopfenstein, T, Moreau, J, Fournier, D, Brunel, A, Lim, P, Oliver, L, Moussafeur, A, Chavanet, P, Piroth, L, Salmon-Rousseau, A, Buisson, M, Mahy, S, Martins, C, Gohier, S, Axler, O, Baumann, F, Lebras, S, Piper, C, Guckel, D, Borgermann, J, Horstkotte, D, Winkelmann, E, Brockmeier, B, Grey, D, Nickenig, G, Schueler, R, Ozturk, C, Stohr, E, Hamm, C, Walther, T, Brandt, R, Fruhauf, A, Hartung, C, Hellner, C, Wild, C, Becker, M, Hamada, S, Kaestner, W, Stangl, K, Knebel, F, Baldenhofer, G, Brecht, A, Dreger, H, Isner, C, Pfafflin, F, Stegemann, M, Zahn, R, Fraiture, B, Kilkowski, C, Karcher, A, Klinger, S, Tolksdorf, H, Tousoulis, D, Aggeli, C, Sideris, S, Venieri, E, Sarri, G, Tsiapras, D, Armenis, I, 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Streukens, S, Chamuleau, S, Cramer, M, Teske, A, Van Der Spoel, T, Wind, A, Lokhorst, J, Liesbek, O, Van Heusden, H, Tanis, W, Van Der Bilt, I, Vriend, J, Lange-Van Bruggen, H, Karijodikoro, E, Riezebos, R, Van Dongen, E, Schoep, J, Stolk, V, Offstad, J, Beitnes, J, Helle-Valle, T, Skulstad, H, Skardal, R, Qamar, N, Ahmed, B, Butt, M, Khanzada, M, Saghir, T, Wahid, A, Hryniewiecki, T, Szymanski, P, Marzec, K, Misztal-Ogonowska, M, Kosmala, W, Przewlocka-Kosmala, M, Rojek, A, Woznicka, K, Zachwyc, J, Lisowska, A, Kaminska, M, Kasprzak, J, Kowalczyk, E, Strzecka, D, Wejner-Mik, P, Trabulo, M, Freitas, P, Ranchordas, S, Rodrigues, G, Pinto, P, Queiros, C, Azevedo, J, Marques, L, Seabra, D, Branco, L, Cruz, M, Galrinho, A, Moreira, R, Rio, P, Timoteo, A, Selas, M, Carmelo, V, Duque Neves, B, Pereira, H, Guerra, A, Marques, A, Pintassilgo, I, Tomescu, M, Trofenciuc, N, Andor, M, Bordejevic, A, Branea, H, Caruntu, F, Velcean, L, Mavrea, A, Onel, M, Parvanescu, T, Pop, D, Pop-Moldovan, A, Puticiu, M, Cirin, L, Citu, I, Cotoraci, C, Darabantiu, D, Farcas, R, Marincu, I, Ionac, A, Cozma, D, Mornos, C, Goanta, F, Popescu, I, Beyer, R, Mada, R, Rancea, R, Tomoaia, R, Rosianu, H, Stanescu, C, Kobalava, Z, Karaulova, J, Kotova, E, Milto, A, Pisaryuk, A, Povalyaev, N, Sorokina, M, Alrahimi, J, Elshiekh, A, Jamiel, A, Ahmed, A, Attia, N, Putnikovic, B, Dimic, A, Ivanovic, B, Matic, S, Trifunovic, D, Petrovic, J, Kosevic, D, Stojanovic, I, Petrovic, I, Dabic, P, Milojevic, P, Srdanovic, I, Susak, S, Velicki, L, Vulin, A, Kovacevic, M, Redzek, A, Stefanovic, M, Yeo, T, Poh, K, Vilacosta, I, Ferrera, C, Olmos, C, Abd El-Nasser, M, Calvo Iglesias, F, Blanco-Gonzalez, E, Bravo Amaro, M, Lopez-Rodriguez, E, Lugo Adan, J, Germinas, A, Pazos-Lopez, P, Pereira Loureiro, M, Perez, M, Raposeiras-Roubin, S, Rasheed Yas, S, Suarez-Varela, M, Vasallo Vidal, F, Garcia-Dorado, D, Fernandez-Hidalgo, N, Gonzalez-Alujas, T, Lozano, J, Maisterra, O, Pizzi, N, Rios, R, Bayes-Genis, A, Pedro Botet, 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de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Chirurgie Cardiovasculaire, University Hospital of Cruces, Geneva University Hospital (HUG), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB), Preventive Medicine Unit, University Hospital Joan XXIII, IISPV, Rovira and Virgili University, Habib, G., Lancellotti, P., Erba, P. -A., Sadeghpour, A., Meshaal, M., Sambola, A., Furnaz, S., Citro, R., Ternacle, J., Donal, E., Cosyns, B., Popescu, B., Iung, B., Prendergast, B., Laroche, C., Tornos, P., Pazdernik, M., Maggioni, A., Gale, C. 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Y., Heo, R., Lee, S., Song, J. -M., Jung, E., Plisiene, J., Dambrauskaite, A., Gruodyte, G., Jonkaitiene, R., Mizariene, V., Atkocaityte, J., Zvirblyte, R., Sow, R., Codreanu, A., Staub, T., Michaux, C., De La Vega, E. C. L., Jacobs-Orazi, L., Mallia Azzopardi, C., Xuereb, R. G., Piscopo, T., Farrugia, J., Fenech, M., Pllaha, E., Vella, C., Borg, D., Casha, R., Grib, L., Raevschi, E., Grejdieru, A., Kravcenco, D., Prisacari, E., Samohvalov, E., Samohvalov, S., Sceglova, N., Panfile, E., Cardaniuc, L., Corcea, V., Feodorovici, A., Gaina, V., Girbu, L., Jimbei, P., Balan, G., Cardaniuc, I., Benesco, I., Marian, V., Sumarga, N., Bozovic, B., Bulatovic, N., Lakovic, P., Music, L., Budde, R., Wahadat, A., Gamela, T., Meijers, T., Van Melle, J. P., Deursen, V. M., Crijns, H. J., Bekkers, S. C., Cheriex, E. C., Gilbers, M., Kietselaer, B. L., Knackstedt, C., Lorusso, R., Schalla, S., Streukens, S. A., Chamuleau, S., Cramer, M. -J., Teske, A., Van Der Spoel, T., Wind, A., Lokhorst, J., Liesbek, O., Van Heusden, H., Tanis, W., Van Der Bilt, I., Vriend, J., Lange-Van Bruggen, H. D., Karijodikoro, E., Riezebos, R., Van Dongen, E., Schoep, J., Stolk, V., Offstad, J. T., Beitnes, J. O., Helle-Valle, T., Skulstad, H., Skardal, R., Qamar, N., Ahmed, B., Butt, M. H., Khanzada, M. F., Saghir, T., Wahid, A., Hryniewiecki, T., Szymanski, P., Marzec, K., Misztal-Ogonowska, M., Kosmala, W., Przewlocka-Kosmala, M., Rojek, A., Woznicka, K., Zachwyc, J., Lisowska, A., Kaminska, M., Kasprzak, J. D., Kowalczyk, E., Strzecka, D. F., Wejner-Mik, P., Trabulo, M., Freitas, P., Ranchordas, S., Rodrigues, G., Pinto, P., Queiros, C., Azevedo, J., Marques, L., Seabra, D., Branco, L., Cruz, M., Galrinho, A., Moreira, R., Rio, P., Timoteo, A. T., Selas, M., Carmelo, V., Duque Neves, B., Pereira, H., Guerra, A., Marques, A., Pintassilgo, I., Tomescu, M. C., Trofenciuc, N. -M., Andor, M., Bordejevic, A., Branea, H. S., Caruntu, F., Velcean, L. A., Mavrea, A., Onel, M. F., Parvanescu, T., Pop, D., Pop-Moldovan, A. L., Puticiu, M. I., Cirin, L., Citu, I. M., Cotoraci, C. A., Darabantiu, D., Farcas, R., Marincu, I., Ionac, A., Cozma, D., Mornos, C., Goanta, F., Popescu, I., Beyer, R., Mada, R., Rancea, R., Tomoaia, R., Rosianu, H., Stanescu, C., Kobalava, Z., Karaulova, J., Kotova, E., Milto, A., Pisaryuk, A., Povalyaev, N., Sorokina, M., Alrahimi, J., Elshiekh, A., Jamiel, A., Ahmed, A., Attia, N., Putnikovic, B., Dimic, A., Ivanovic, B., Matic, S., Trifunovic, D., Petrovic, J., Kosevic, D., Stojanovic, I., Petrovic, I., Dabic, P., Milojevic, P., Srdanovic, I., Susak, S., Velicki, L., Vulin, A., Kovacevic, M., Redzek, A., Stefanovic, M., Yeo, T. C., Kong, W. K. F., Poh, K. K., Vilacosta, I., Ferrera, C., Olmos, C., Abd El-Nasser, M., Calvo Iglesias, F., Blanco-Gonzalez, E., Bravo Amaro, M., Lopez-Rodriguez, E., Lugo Adan, J., Germinas, A. N., Pazos-Lopez, P., Pereira Loureiro, M., Perez, M. T., Raposeiras-Roubin, S., Rasheed Yas, S., Suarez-Varela, M. -M., Vasallo Vidal, F., Garcia-Dorado, D., Fernandez-Hidalgo, N., Gonzalez-Alujas, T., Lozano, J., Maisterra, O., Pizzi, N., Rios, R., Bayes-Genis, A., Pedro Botet, L., Vallejo, N., Llibre, C., Mateu, L., Nunez, R., Quesada, D., Berastegui, E., Bosch Portell, D., Aboal Vinas, J., Albert Bertran, X., Brugada Tarradellas, R., Loma-Osorio Ricon, P., Tiron De Llano, C., Arnau, M. A., Bel, A., Blanes, M., Osa, A., Anguita, M., Carrasco, F., Castillo, J. C., Zamorano, J. L., Moya Mur, J. L., Alvaro, M., Fernandez-Golfin, C., Monteagudo, J. M., Navas Elorza, E., Farinas Alvarez, M. C., Aguero Balbin, J., Zarauza, J., Gutierrez-Diez, J. F., Arminanzas, C., Arnaiz De Las Revillas, F., Arnaiz Garcia, A., Cobo Belaustegui, M., Fernandez Sampedro, M., Gutierrez Cuadra, M., Garcia Cuello, L., Gonzalez Rico, C., Rodriguez-Alvarez, R., Goikoetxea, J., Montejo, M., Miro, J. M., Almela, M., Ambrosioni, J., Moreno, A., Quintana, E., Sandoval, E., Tellez, A., Tolosana, J. M., Vidal, B., Falces, C., Fuster, D., Garcia-De-La-Maria, C., Hernandez-Meneses, M., Llopis, J., Marco, F., Ruiz-Zamora, I., Bardaji Ruiz, A., Sanz Girgas, E., Garcia-Pardo, G., Guillen Marzo, M., Rodriguez Oviedo, A., Villares Jimenez, A., Abid, L., Hammami, R., Kammoun, S., Mourali, M. S., Ben Hlima, M., Boudiche, S., Ouali, S., Zakhama, L., Antit, S., Slama, I., Gulel, O., Sahin, M., Karacaglar, E., Kucukoglu, S., Cetinarslan, O., Yasar, U. S., Canpolat, U., Mutlu, B., Atas, H., Dervishova, R., Ileri, C., Alhashmi, J., Tahir, J., Zarger, P., Baslib, F., Woldman, S., Menezes, L., Primus, C., Uppal, R., Bvekerwa, I., Chandrasekaran, B., Kopanska, A., Chambers, J., Hancock, J., Klein, J., Rajani, R., Ursi, M. P., Cannata, S., Dworakowski, R., Fife, A., Breeze, J., Browne-Morgan, M., Gunning, M., Streather, S., Asch, F. M., Zemedkun, M., Alyavi, B., Uzokov, J., RS: Carim - H01 Clinical atrial fibrillation, MUMC+: MA Cardiologie (9), Cardiologie, RS: CARIM - R3.11 - Imaging, RS: CARIM - R2.01 - Clinical atrial fibrillation, MUMC+: MA Med Staf Artsass CTC (9), Promovendi CD, Fysiologie, RS: CARIM - R1.06 - Genetic Epidemiology and Genomics of cardiovascular diseases, MUMC+: MA Med Staf Spec Cardiologie (9), RS: Carim - V04 Surgical intervention, CTC, MUMC+: MA Med Staf Spec CTC (9), RS: CARIM - R2.12 - Surgical intervention, RS: Carim - H02 Cardiomyopathy, and RS: CARIM - R2.02 - Cardiomyopathy
Subjects: medicine.medical_specialty, Registry, MEDLINE, Infective endocarditi, infective endocarditis, registry, valve disease, Disease, Infective endocarditis, Valve disease, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Epidemiology, medicine, Journal Article, MANAGEMENT, Endocarditis, Humans, 030212 general & internal medicine, Registries, Intensive care medicine, health care economics and organizations, Surrogate endpoint, business.industry, Health Policy, Patient data, MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, medicine.disease, 3. Good health, Cardiac surgery, Europe, Practice Guidelines as Topic, business, Cardiology and Cardiovascular Medicine, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Aims The European Society of Cardiology (ESC) EURObservational Research Programme (EORP) European Endocarditis (EURO-ENDO) registry aims to study the care and outcomes of patients diagnosed with infective endocarditis (IE) and compare findings with recommendations from the 2015 ESC Clinical Practice Guidelines for the management of IE and data from the 2001 Euro Heart Survey. Methods and results Patients (n = 3116) aged over 18 years with a diagnosis of IE based on the ESC 2015 IE diagnostic criteria were prospectively identified between 1 January 2016 and 31 March 2018. Individual patient data were collected across 156 centres and 40 countries. The primary endpoint is all-cause mortality in hospital and at 1 year. Secondary endpoints are 1-year morbidity (all-cause hospitalization, any cardiac surgery, and IE relapse), the clinical, epidemiological, microbiological, and therapeutic characteristics of patients, the number and timing of non-invasive imaging techniques, and adherence to recommendations as stated in the 2015 ESC Clinical Practice Guidelines for the management of IE. Conclusion EURO-ENDO is an international registry of care and outcomes of patients hospitalized with IE which will provide insights into the contemporary profile and management of patients with this challenging disease.
Published: 2019

96. Characteristics, management, and outcomes of patients with left-sided infective endocarditis complicated by heart failure:a substudy of the ESC-EORP EURO-ENDO (European infective endocarditis) registry

Author: Bohbot, Yohann, Habib, Gilbert, Laroche, Cécile, Stöhr, Elisabeth, Chirouze, Catherine, Hernandez-Meneses, Marta, Melissopoulou, Maria, Mutlu, Bülent, Scheggi, Valentina, Branco, Luísa, Olmos, Carmen, Reyes, Graciela, Pazdernik, Michal, Iung, Bernard, Sow, Rouguiatou, Mirocevic, Maja, Lancellotti, Patrizio, Tribouilloy, Christophe, P Gale, C, Beleslin, B, Budaj, A, Chioncel, O, Dagres, N, Danchin, N, Emberson, J, Erlinge, D, Glikson, M, Gray, A, Kayikcioglu, M, P Maggioni, A, K Nagy, V, Nedoshivin, A, A-S, Petronio, Roos-Hesselink, J, Wallentin, L, Zeymer, U, Habib, G, Lancellotti, P, Cosyns, B, Donal, E, Erba, P, Iung, B, A Popescu, B, Prendergast, B, Tornos, P, Andarala, M, Berle, C, Brunel-Lebecq, A, Fiorucci, E, Laroche, C, Missiamenou, V, Taylor, C, N Ali Tatar-Chentir, N, Al-Mallah, M, M Astrom Aneq, Athanassopoulos, G, P Badano, L, Benyoussef, S, E Calderon Aranda, M Cardim, N, K-L, Chan, Cruz, I, Edvardsen, T, Goliasch, G, Hagendorff, A, Hristova, K, Kamp, O, D-H, Kang, Kong, W, Matskeplishvili, S, Meshaal, M, Mirocevic, M, N Neskovic, A, Pazdernik, M, Plonska-Gosciniak, E, Raissouni, M, Ronderos, R, E Sade, L, Sadeghpour, A, Sambola, A, Sengupta, S, Separovic-Hanzevacki, J, Takeuchi, M, Tucay, E, C Tude Rodrigues, A, Varga, A, Vaskelyte, J, Yamagata, K, Yiangou, K, Zaky, H, Granada, I, Mahia, M, Ressi, S, Nacinovich, F, Iribarren, A, P Fernandez Oses, Avegliano, G, Filipini, E, Obregon, R, Bangher, M, Dho, J, Cartasegna, L, L Plastino, M, Novas, V, Shigel, C, Reyes, G, M De Santos, Gastaldello, N, M Granillo Fernandez, Potito, M, Streitenberger, G, Velazco, P, H Casabé, J, Cortes, C, Guevara, E, Salmo, F, Seijo, M, Weidinger, F, Heger, M, Brooks, R, Stöllberger, C, C-Y, Ho, Perschy, L, Puskas, L, Binder, C, Rosenhek, R, Schneider, M, M-P, Winter, Hoffer, E, Melissopoulou, M, Lecoq, E, Legrand, D, Jacquet, S, Massoz, M, Pierard, L, Marchetta, S, Dulgheru, R, D'Emal, C, Oury, C, Droogmans, S, Kerkhove, D, Plein, D, Soens, L, Weytjens, C, Motoc, A, 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L Moya Mur, J, Alvaro, M, Fernandez-Golfin, C, M Monteagudo, J, E Navas Elorza, C Farinas Alvarez, M, J Aguero Balbin, Zarauza, J, F Gutierrez-Diez, J, Arminanzas, C, F Arnaiz de Las Revillas, A Arnaiz Garcia, M Cobo Belaustegui, M Fernandez Sampedro, M Gutierrez Cuadra, L Garcia Cuello, C Gonzalez Rico, Rodriguez-Alvarez, R, Goikoetxea, J, Montejo, M, M Miro, J, Almela, M, Ambrosioni, J, Moreno, A, Quintana, E, Sandoval, E, Tellez, A, M Tolosana, J, Vidal, B, Falces, C, Fuster, D, Garcia-de-la-Maria, C, Hernandez-Meneses, M, Llopis, J, Marco, F, Ruiz-Zamora, I, A Bardaji Ruiz, E Sanz Girgas, Garcia-Pardo, G, M Guillen Marzo, A Rodriguez Oviedo, A Villares Jimenez, Abid, L, Hammami, R, Kammoun, S, S Mourali, M, F Mghaieth Zghal, M Ben Hlima, Boudiche, S, Ouali, S, Zakhama, L, Antit, S, Slama, I, Gulel, O, Sahin, M, Karacaglar, E, Kucukoglu, S, Cetinarslan, O, Y Sinan, U, Canpolat, U, Mutlu, B, Atas, H, Dervishova, R, Ileri, C, Alhashmi, J, Tahir, J, Zarger, P, Baslib, F, Woldman, S, Menezes, L, Primus, C, Uppal, R, Bvekerwa, I, Chandrasekaran, B, Kopanska, A, Chambers, J, Hancock, J, Klein, J, Rajani, R, P Ursi, M, Cannata, S, Dworakowski, R, Fife, A, Breeze, J, Browne-Morgan, M, Gunning, M, Streather, S, M Asch, F, Zemedkun, M, Alyavi, B, Uzokov, J, European Infective Endocarditis Registry (Euro-Endo), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Hôpital de la Timone [CHU - APHM] (TIMONE), Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, CHU Amiens-Picardie, CHU Pontchaillou [Rennes], ARN régulateurs bactériens et médecine (BRM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de Cardiologie [Hôpital de la Timone - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), EURObservational Research Programme, European Society of Cardiology, Careggi University Hospital [Florence, Italie], Hospital de Alta Complejidad El Cruce 'Nestor Kirchner', Florencio Varela, Buenos Aires, Centre Hospitalier Universitaire de Liège (CHU-Liège), Maria Cecilia Hospital [Cotignola], Anthea Hospital [Bari, Italy], Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Bohbot, Yohann, Habib, Gilbert, Laroche, Cécile, Stöhr, Elisabeth, Chirouze, Catherine, Hernandez-Meneses, Marta, Melissopoulou, Maria, Mutlu, Bülent, Scheggi, Valentina, Branco, Luísa, Olmos, Carmen, Reyes, Graciela, Pazdernik, Michal, Iung, Bernard, Sow, Rouguiatou, Mirocevic, Maja, Lancellotti, Patrizio, Tribouilloy, Christophe, Agricola, Eustachio, Cardiology, ACS - Heart failure & arrhythmias, Neurosurgery, Graduate School, Radiotherapy, ACS - Atherosclerosis & ischemic syndromes, Clinical sciences, Cardio-vascular diseases, Medical Imaging, Bohbot Y., Habib G., Laroche C., Stohr E., Chirouze C., Hernandez-Meneses M., Melissopoulou M., Mutlu B., Scheggi V., Branco L., et al., Bohbot, Y, Habib, G, Laroche, C, Stohr, E, Chirouze, C, Hernandez-Meneses, M, Melissopoulou, M, Mutlu, B, Scheggi, V, Branco, L, Olmos, C, Reyes, G, Pazdernik, M, Iung, B, Sow, R, Mirocevic, M, Lancellotti, P, Tribouilloy, C, Gale, C, Beleslin, B, Budaj, A, Chioncel, O, Dagres, N, Danchin, N, Emberson, J, Erlinge, D, Glikson, M, Gray, A, Kayikcioglu, M, Maggioni, A, Nagy, V, Nedoshivin, A, Petronio, A, Roos-Hesselink, J, Wallentin, L, Zeymer, U, Cosyns, B, Donal, E, Erba, P, Popescu, B, Prendergast, B, Tornos, P, Andarala, M, Berle, C, Brunel-Lebecq, A, Fiorucci, E, Missiamenou, V, Taylor, C, Ali Tatar-Chentir, N, Al-Mallah, M, Astrom Aneq, M, Athanassopoulos, G, Badano, L, Benyoussef, S, Calderon Aranda, E, Cardim, N, Chan, K, Cruz, I, Edvardsen, T, Goliasch, G, Hagendorff, A, Hristova, K, Kamp, O, Kang, D, Kong, W, Matskeplishvili, S, Meshaal, M, Neskovic, A, Plonska-Gosciniak, E, Raissouni, M, Ronderos, R, Sade, L, Sadeghpour, A, Sambola, A, Sengupta, S, Separovic-Hanzevacki, J, Takeuchi, M, Tucay, E, Tude Rodrigues, A, Varga, A, Vaskelyte, J, Yamagata, K, Yiangou, K, Zaky, H, Granada, I, Mahia, M, Ressi, S, Nacinovich, F, Iribarren, A, Fernandez Oses, P, Avegliano, G, Filipini, E, Obregon, R, Bangher, M, Dho, J, Cartasegna, L, Plastino, M, Novas, V, Shigel, C, De Santos, M, Gastaldello, N, Granillo Fernandez, M, Potito, M, Streitenberger, G, Velazco, P, Casabe, J, Cortes, C, Guevara, E, Salmo, F, Seijo, M, Weidinger, F, Heger, M, Brooks, R, Stollberger, C, Ho, C, Perschy, L, Puskas, L, Binder, C, Rosenhek, R, Schneider, M, Winter, M, Hoffer, E, Lecoq, E, Legrand, D, Jacquet, S, Massoz, M, Pierard, L, Marchetta, S, Dulgheru, R, D'Emal, C, Oury, C, Droogmans, S, Kerkhove, D, Plein, D, Soens, L, Weytjens, C, Motoc, A, Roosens, B, Lemoine, I, Rodrigus, I, Paelinck, B, Amsel, B, Unger, P, Konopnicki, D, Beauloye, C, Pasquet, A, Vanoverschelde, J, Pierard, S, Vancraeynest, D, Sinnaeve, F, Andrade, J, Staszko, K, Dos Santos Monteiro, R, Miglioranza, M, Shuha, D, Alcantara, M, Cravo, V, Fazzio, L, Felix, A, Iso, M, Musa, C, Siciliano, A, Villaca Filho, F, Rodrigues, A, Vilela, F, Braga, J, Silva, R, Rodrigues, D, Silva, L, Morhy, S, Fischer, C, Vieira, M, Afonso, T, Abreu, J, Falcao, S, Moises, V, Gouvea, A, Mancuso, F, Souza, A, Silva, C, Joao, G, Abboud, C, Bellio de Mattos Barretto, R, Ramos, A, Arnoni, R, Assef, J, Della Togna, D, Le Bihan, D, Miglioli, L, Romero Oliveira, A, Tadeu Magro Kroll, R, Cortez, D, Gelape, C, Peirira Nunes, M, De Abreu Ferrari, T, Hay, K, Le, V, Page, M, Poulin, F, Sauve, C, Serri, K, Mercure, C, Beaudoin, J, Pibarot, P, Sebag, I, Rudski, L, Ricafort, G, Barsic, B, Krajinovic, V, Vargovic, M, Lovric, D, Reskovic-Luksic, V, Vincelj, J, Jaksic Jurinjak, S, Yiannikourides, V, Ioannides, M, Pofaides, C, Masoura, V, Pudich, J, Linhart, A, Siranec, M, Marek, J, Blechova, K, Kamenik, M, Pelouch, R, Coufal, Z, Mikulica, M, Griva, M, Jancova, E, Mikulcova, M, Taborsky, M, Precek, J, Jecmenova, M, Latal, J, Widimsky, J, Butta, T, Machacek, S, Vancata, R, Spinar, J, Holicka, M, Pow Chon Long, F, Anzules, N, Bajana Carpio, A, Largacha, G, Penaherrera, E, Moreira, D, Mahfouz, E, Elsafty, E, Soliman, A, Zayed, Y, 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Aggeli, C, Sideris, S, Venieri, E, Sarri, G, Tsiapras, D, Armenis, I, Koutsiari, A, Floros, G, Grassos, C, Dragasis, S, Rallidis, L, Varlamos, C, Michalis, L, Naka, K, Bechlioulis, A, Kotsia, A, Lakkas, L, Pappas, K, Papadopoulos, C, Kiokas, S, Lioni, A, Misailidou, S, Barbetseas, J, Bonou, M, Kapelios, C, Tomprou, I, Zerva, K, Manolis, A, Hamodraka, E, Athanasiou, D, Haralambidis, G, Samaras, H, Poulimenos, L, Nagy, A, Bartykowszki, A, Gara, E, Mungulmare, K, Kasliwal, R, Bansal, M, Ranjan, S, Bhan, A, Kyavar, M, Maleki, M, Bezanjani, F, Alizadehasl, A, Boudagh, S, Ghavidel, A, Moradnejad, P, Pasha, H, Ghadrdoost, B, Gilon, D, Strahilevitz, J, Wanounou, M, Israel, S, D'Agostino, C, Colonna, P, De Michele, L, Fumarola, F, Stante, M, Marchionni, N, Alterini, B, Del Pace, S, Stefano, P, Sparano, C, Ruozi, N, Tenaglia, R, Muraru, D, Limbruno, U, Cresti, A, Baratta, P, Solari, M, Giannattasio, C, Moreo, A, De Chiara, B, Lopez Montero, B, Musca, F, Orcese, C, Panzeri, F, Spano, F, Russo, C, 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Fujimaki, H, Shitan, H, Yamamoto, H, Abe, K, Terada, M, Takanashi, S, Sata, M, Yamada, H, Kusunose, K, Saijo, Y, Seno, H, Yuichiro, O, Onishi, T, Sera, F, Nakatani, S, Mizuno, H, Sengoku, K, Park, S, Kyoung, K, Yeon, L, Hwang, J, Jin-Oh, C, Sang-Chol, L, Sung-A, C, Jang, S, Heo, R, Lee, S, Song, J, Jung, E, Plisiene, J, Dambrauskaite, A, Gruodyte, G, Jonkaitiene, R, Mizariene, V, Atkocaityte, J, Zvirblyte, R, Codreanu, A, Staub, T, Michaux, C, De la Vega, E, Jacobs-Orazi, L, Mallia Azzopardi, C, Xuereb, R, Piscopo, T, Farrugia, J, Fenech, M, Pllaha, E, Vella, C, Borg, D, Casha, R, Grib, L, Raevschi, E, Grejdieru, A, Kravcenco, D, Prisacari, E, Samohvalov, E, Samohvalov, S, Sceglova, N, Panfile, E, Cardaniuc, L, Corcea, V, Feodorovici, A, Gaina, V, Girbu, L, Jimbei, P, Balan, G, Cardaniuc, I, Benesco, I, Marian, V, Sumarga, N, Bozovic, B, Bulatovic, N, Lakovic, P, Music, L, Budde, R, Wahadat, A, Gamela, T, Meijers, T, Van Melle, J, Deursen, V, Crijns, H, Bekkers, S, Cheriex, E, Gilbers, M, Kietselaer, B, Knackstedt, C, Lorusso, R, Schalla, S, Streukens, S, Chamuleau, S, Cramer, M, Teske, A, Van der Spoel, T, Wind, A, Lokhorst, J, Liesbek, O, Van Heusden, H, Tanis, W, Van der Bilt, I, Vriend, J, De Lange-van Bruggen, H, Karijodikoro, E, Riezebos, R, van Dongen, E, Schoep, J, Stolk, V, Offstad, J, Beitnes, J, Helle-Valle, T, Skulstad, H, Skardal, R, Qamar, N, Furnaz, S, Ahmed, B, Butt, M, Khanzada, M, Saghir, T, Wahid, A, Hryniewiecki, T, Szymanski, P, Marzec, K, Misztal-Ogonowska, M, Kosmala, W, Przewlocka-Kosmala, M, Rojek, A, Woznicka, K, Zachwyc, J, Lisowska, A, Kaminska, M, Kasprzak, J, Kowalczyk, E, Strzecka, D, Wejner-Mik, P, Trabulo, M, Freitas, P, Ranchordas, S, Rodrigues, G, Pinto, P, Queiros, C, Azevedo, J, Marques, L, Seabra, D, Cruz, M, Galrinho, A, Moreira, R, Rio, P, Timoteo, A, Selas, M, Carmelo, V, Duque Neves, B, Pereira, H, Guerra, A, Marques, A, Pintassilgo, I, Tomescu, M, Trofenciuc, N, Andor, M, Bordejevic, A, Branea, H, Caruntu, F, Velcean, L, 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O, Pizzi, N, Rios, R, Bayes-Genis, A, Pedro Botet, L, Vallejo, N, Llibre, C, Mateu, L, Nunez, R, Quesada, D, Berastegui, E, Bosch Portell, D, Aboal Vinas, J, Albert Bertran, X, Brugada Tarradellas, R, Loma-Osorio Ricon, P, Tiron de Llano, C, Arnau, M, Bel, A, Blanes, M, Osa, A, Anguita, M, Carrasco, F, Castillo, J, Zamorano, J, Moya Mur, J, Alvaro, M, Fernandez-Golfin, C, Monteagudo, J, Navas Elorza, E, Farinas Alvarez, M, Aguero Balbin, J, Zarauza, J, Gutierrez-Diez, J, Arminanzas, C, Arnaiz de las Revillas, F, Arnaiz Garcia, A, Cobo Belaustegui, M, Fernandez Sampedro, M, Gutierrez Cuadra, M, Garcia Cuello, L, Gonzalez Rico, C, Rodriguez-Alvarez, R, Goikoetxea, J, Montejo, M, Miro, J, Almela, M, Ambrosioni, J, Moreno, A, Quintana, E, Sandoval, E, Tellez, A, Tolosana, J, Vidal, B, Falces, C, Fuster, D, Garcia-de-la-Maria, C, Llopis, J, Marco, F, Ruiz-Zamora, I, Bardaji Ruiz, A, Sanz Girgas, E, Garcia-Pardo, G, Guillen Marzo, M, Rodriguez Oviedo, A, Villares Jimenez, A, Abid, L, Hammami, R, Kammoun, S, Mourali, M, Mghaieth Zghal, F, Ben Hlima, M, Boudiche, S, Ouali, S, Zakhama, L, Antit, S, Slama, I, Gulel, O, Sahin, M, Karacaglar, E, Kucukoglu, S, Cetinarslan, O, Sinan, U, Canpolat, U, Atas, H, Dervishova, R, Ileri, C, Alhashmi, J, Tahir, J, Zarger, P, Baslib, F, Woldman, S, Menezes, L, Primus, C, Uppal, R, Bvekerwa, I, Chandrasekaran, B, Kopanska, A, Chambers, J, Hancock, J, Klein, J, Rajani, R, Ursi, M, Cannata, S, Dworakowski, R, Fife, A, Breeze, J, Browne-Morgan, M, Gunning, M, Streather, S, Asch, F, Zemedkun, M, Alyavi, B, and Uzokov, J
Subjects: Male, Congestive heart failure, Survival, SURGERY, IMPACT, Hospital mortality, Infective endocarditi, Sağlık Bilimleri, Cardiovascular, Clinical Medicine (MED), Endocarditis, Bacterial/complications, PROGNOSTIC-FACTORS, KALP VE KALP DAMAR SİSTEMLERİ, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Early surgery, Klinik Tıp (MED), Prospective Studies, Registries, PREDICTORS, ComputingMilieux_MISCELLANEOUS, Outcome, RISK, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Klinik Tıp, DEATH, Middle Aged, Tıp, Heart Failure/complications, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Medicine, Female, EURO-ENDO, Cardiology and Cardiovascular Medicine, Kardiyoloji, Kardiyoloji ve Kardiyovasküler Tıp, NATIVE VALVE ENDOCARDITIS, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Endocarditis/complications, Health Sciences, Humans, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Retrospective Studies, Internal Medicine Sciences, MORTALITY, MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Dahili Tıp Bilimleri, ADULTS, Infective endocarditis, CLINICAL MEDICINE, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, CARDIAC & CARDIOVASCULAR SYSTEMS
Abstract: International audience; AIMS: To evaluate the current management and survival of patients with left-sided infective endocarditis (IE) complicated by congestive heart failure (CHF) in the ESC-EORP European Endocarditis (EURO-ENDO) registry. METHODS AND RESULTS: Among the 3116 patients enrolled in this prospective registry, 2449 (mean age: 60 years, 69% male) with left-sided (native or prosthetic) IE were included in this study. Patients with CHF (n~=~698, 28.5%) were older, with more comorbidity and more severe valvular damage (mitro-aortic involvement, vegetations >10\,mm and severe regurgitation/new prosthesis dehiscence) than those without CHF (all p\,≤q\,0.019). Patients with CHF experienced higher 30-day and 1-year mortality than those without (20.5% vs. 9.0% and 36.1% vs. 19.3%, respectively) and CHF remained strongly associated with 30-day (odds ratio[OR] 2.37, 95% confidence interval [CI] [1.73-3.24; p\,10\,mm, severe valvular regurgitation and/or new prosthetic dehiscence, perivalvular complication, and prosthetic IE (OR 0.22, 95% CI 0.12-0.38; p\
Published: 2022

97. Abnormal left atrial strain is associated with eventual diagnosis of atrial fibrillation in patients with embolic stroke of undetermined source

Author: Zheng, Y, primary, Li, T Y W, additional, Goh, F Q, additional, Ong, J S P, additional, Low, C H X, additional, Ho, J S Y, additional, Chan, M Y, additional, Seow, S C, additional, Kong, W K F, additional, Poh, K K, additional, Wong, R C C, additional, Yeo, T C, additional, Yeo, L L L, additional, Tan, B Y Q, additional, and Sia, C H, additional
Published: 2023
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98. Effects of epicardial adipose tissue volume and thickness assessed by computed tomography and echocardiography on cardiovascular and cerebrovascular outcomes: a systematic review and meta-analysis

Author: Chong, B, primary, Jayabaskaran, J, additional, Ruban, J, additional, Goh, R, additional, Chin, Y H, additional, Kong, G, additional, Ng, C H, additional, Foo, R, additional, Chai, P, additional, Kong, W, additional, Poh, K K, additional, Chan, M Y, additional, Mehta, A, additional, Dimitriadis, G K, additional, and Chew, N W S, additional
Published: 2023
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99. Natural history of functional mitral regurgitation: a systematic review and individual patient data meta-analysis

Author: Teo, Y N, primary, Basker, G, additional, Teoh, S E, additional, Tan, E W X, additional, Teo, Y H, additional, Chai, P, additional, Wong, R C C, additional, Yip, J W L, additional, Kuntjoro, I, additional, Lim, Y, additional, Poh, K K, additional, Yeo, T C, additional, Kong, W K F, additional, and Sia, C H, additional
Published: 2023
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100. Sex differences in the evaluation and outcomes of multi-ethnic asian patients undergoing stress echocardiography

Author: Seah, C H X, primary, Lau, J K X, additional, Li, T Y W, additional, Tiong, C Y, additional, Poh, K K, additional, Sia, C H, additional, Wong, R C C, additional, and Kong, W K F, additional
Published: 2023
Full Text: View/download PDF

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