51. The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation
- Author
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I. Cnop, E. J. P. de Koning, John F. Morris, Michael B. Hoppa, Jennifer H. Gunter, Miriam Cnop, S. J. Hughes, Miriam Pipeleers-Marichal, Gerard V Walls, Anna Clark, Mariana Igoillo-Esteve, Barbara C. Hansen, F. Sayyed, D. W. G. Gray, L. van de Laar, Paul Johnson, Analysis, Mathematics in Education, and Pathological Anatomy
- Subjects
Adult ,Senescence ,Aging ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Population ,Longevity ,030209 endocrinology & metabolism ,Type 2 diabetes ,Biology ,Neogenesis ,Lipofuscin ,Mice ,03 medical and health sciences ,Age Distribution ,0302 clinical medicine ,Cause of Death ,Insulin-Secreting Cells ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,Animals ,Humans ,Ageing Human Islet Longevity Mathematical modelling Monkey Mouse Neogenesis Pancreatic beta cell Type 2 diabetes low-density-lipoprotein oxidative stress partial-pancreatectomy insulin-secretion mass age proliferation regeneration apoptosis birth ,Beta (finance) ,education ,Pancreas ,030304 developmental biology ,0303 health sciences ,geography ,education.field_of_study ,geography.geographical_feature_category ,islet ,Mathematical modelling ,Models, Theoretical ,Islet ,medicine.disease ,biology.organism_classification ,Macaca mulatta ,Tissue Donors ,Mice, Inbred C57BL ,Ageing ,Endocrinology ,Diabetes Mellitus, Type 2 ,Beta cell ,Biomarkers ,Cell Division ,Human - Abstract
AIMS/HYPOTHESIS: Defects in pancreatic beta cell turnover are implicated in the pathogenesis of type 2 diabetes by genetic markers for diabetes. Decreased beta cell neogenesis could contribute to diabetes. The longevity and turnover of human beta cells is unknown; in rodents or=90% (or=97% (>20 years) and remained constant thereafter. CONCLUSIONS/INTERPRETATION: Human beta cells, unlike those of young rodents, are long-lived. LB proportions in type 2 diabetes and obesity suggest that little adaptive change occurs in the adult human beta cell population, which is largely established by age 20 years.
- Published
- 2010