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The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation
- Source :
- Diabetologia, 53(2), 321-330, Diabetologia; Vol 53
- Publication Year :
- 2010
-
Abstract
- AIMS/HYPOTHESIS: Defects in pancreatic beta cell turnover are implicated in the pathogenesis of type 2 diabetes by genetic markers for diabetes. Decreased beta cell neogenesis could contribute to diabetes. The longevity and turnover of human beta cells is unknown; in rodents or=90% (or=97% (>20 years) and remained constant thereafter. CONCLUSIONS/INTERPRETATION: Human beta cells, unlike those of young rodents, are long-lived. LB proportions in type 2 diabetes and obesity suggest that little adaptive change occurs in the adult human beta cell population, which is largely established by age 20 years.
- Subjects :
- Adult
Senescence
Aging
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Population
Longevity
030209 endocrinology & metabolism
Type 2 diabetes
Biology
Neogenesis
Lipofuscin
Mice
03 medical and health sciences
Age Distribution
0302 clinical medicine
Cause of Death
Insulin-Secreting Cells
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Animals
Humans
Ageing Human Islet Longevity Mathematical modelling Monkey Mouse Neogenesis Pancreatic beta cell Type 2 diabetes low-density-lipoprotein oxidative stress partial-pancreatectomy insulin-secretion mass age proliferation regeneration apoptosis birth
Beta (finance)
education
Pancreas
030304 developmental biology
0303 health sciences
geography
education.field_of_study
geography.geographical_feature_category
islet
Mathematical modelling
Models, Theoretical
Islet
medicine.disease
biology.organism_classification
Macaca mulatta
Tissue Donors
Mice, Inbred C57BL
Ageing
Endocrinology
Diabetes Mellitus, Type 2
Beta cell
Biomarkers
Cell Division
Human
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Diabetologia, 53(2), 321-330, Diabetologia; Vol 53
- Accession number :
- edsair.doi.dedup.....62e70c6e5c6c6154aa43945f208747ba