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Phosphate sol-gel-derived glasses in a P2O5-CaO-Na2O-TiO2 system with a high TiO2 content of up to 50 mol% were synthesized. A sol-gel method was chosen because incorporating a high percentage of titanium into the phosphate network via traditional melt-quench methods is not trivial. The structural and the thermal properties of the obtained stabilized sol-gel glasses were characterized using X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, and differential scanning calorimetry. The XRD results confirmed the amorphous and glassy nature of the prepared samples. The FTIR results revealed that, with the addition of TiO2, titanium oxide (TiO6) (which likely acts as a modifier oxide) entered the network. Consequently, the number of terminal oxygen atoms increased, leading to an increase in the number of P-OH bonds. The proton conductivity of the sol-gel glass samples was as high as 0.0102 S·cm−1 at a relative humidity of 100% and a temperature of 100 ◦ C. The FTIR analysis confirmed the presence of (HPO4)2− - and (H2PO4)−-coordinated phosphorous. These functional groups acted as a bridge in the Grotthuss proton-conduction mechanism.

Atopic dermatitis, a chronic relapsing and pruritic inflammation of the skin also thought to be involved in, or caused by immune system destruction is an upsetting health problem due to its continuously increasing incidence especially in developed countries. Mast cell infiltration in atopic dermatitis skin lesions and its IgE-mediated activation releases various cytokines and chemokines that have been implicated in the pathogenesis of atopic dermatitis. This study was aimed at investigating synergistic anti-inflammatory, anti-pruritic and anti-atopic dermatitis effects of Diospyros lotus leaf extract (DLE) and Muscat bailey A grapefruit stem extract (GFSE) in atopic dermatitis-like induced skin lesions in mice. Combinations of DLE and GFSE inhibited TNF-α and IL-6 production more than DLE or GFSE in PMA plus calcium ionophore A23187-activated HMC-1 cells. DLE and GFSE synergistically inhibited compound 48/80-induced dermal infiltration of mast cells and reduced scratching behavior than DLE or GFSE. Furthermore, DLE and GFSE synergistically showed a stronger ameliorative effect in skin lesions by reducing clinical scores; dermal infiltration of mast cells; ear and dorsal skin thickness; serum IgE and IL-4 production in atopic dermatitis-like mice. Collectively, these results suggest that DLE and GFSE synergistically exhibit anti-atopic dermatitis effects in atopic dermatitis-like skin lesions in mice.

With the ever-increasing demand for both highperformance and low-power memory modules, it is becoming more and more difficult to meet the SI/PI-related target specifications. This problem can be further aggravated as the supply voltage of Double Data Rate (DDR) memory module decreases from 1.2 V down to 1.1 V for DDR5, possibly resulting in more logic malfunctions of the system. In order to mitigate these problems, Power Management Integrated Circuit (PMIC) is adopted on the DDR5 module to enhance the PI performance. Accordingly, an accurate evaluation of its characteristics has become of utmost importance for prediction of module-level voltage ripple (AC) and IR drop (DC) characteristics. In this paper, a novel methodology for accurate analysis of module-level PI performance, which includes non-linear PMIC characteristics along with other power models of passive components and CPM, is proposed. Through a series of simulations in both time and frequency domains, we successfully verified the accuracy of the proposed methodology and proved its high practicality.

Houttuynia cordata (HC) is a traditional oriental herbal medicinal plant widely used as a component of complex prescriptions in Asia for alopecia treatment. The effect of HC on hair growth and its underlying mechanism, however, have not been demonstrated or clarified. In this study, we investigated the hair growth promoting effect of HC in cultured human dermal papilla cells (hDPCs). HC extract was found to stimulate the proliferation of hDPCs and this stimulation might be in part a consequence of activated cellular energy metabolism, because treatment of HC extract increased the generation of nicotinamide adenine dinucleotide (NADH) and ATP through increasing the mitochondrial membrane potential (ΔΨ). In the context of cell cycle, HC extract increased the expression of CDK4 and decreased the expression of CCNA2 and CCNB1, implying that HC extract might induce G1 phase progression of DPCs which resulted in enhanced proliferation. HC extract increased the expression of Bcl2 essential for maintaining hair follicle anagen stage and cell survival. On the contrary, the expression of p16 and p21 was down-regulated by HC extract. In addition, HC extract enhanced the secretion of platelet-derived growth factor (PDGF)-aa and vascular endothelial growth factor (VEGF) and induced phosphorylation of extracellular signal-regulated kinase (ERK) and AKT. Furthermore, HC extract prolonged anagen stage in organ cultured human hair follicles. Our data strongly suggest that HC extract could support hair growth by stimulating proliferation of DPCs and elongating anagen stage, resulted from enhanced cellular energy metabolism and modulation of gene expression related to cell cycle, apoptosis, and growth factors.

This study investigated the ameliorative effects of acid hydrolyzed celery extract (HCE) and celery extract (CE) in an atopic dermatitis (AD) mice model. The results of the study showed that HCE, more than CE improved AD-like skin lesions caused by fluoro-2,4-dinitrobenzene and house dust mite antigen administration. Further analysis also showed the dominance of HCE than CE in preventing mast cell infiltration in the dermis; inhibiting the IL-31 expression in mice skin and reducing the immunoglobulin-E, IL-4, IL-5, TNF-α, IFN-γ, IL-31, and TSLP in serum of mice. Using in vitro studies in a murine macrophage cell line, we showed that apigetrin, luteolin, and apigenin present in both extracts could be accountable for the observed effects as these three compounds and not apiin prevented the nitric oxide production in the murine macrophage. Based on this study, we suggest that hydrolyzing celery extracts can improve the therapeutic efficacy of celery extracts for management of AD. PRACTICAL APPLICATIONS: Apigenin, apigetrin, and luteolin are known biologically active compounds present in celery. Acid hydrolysis could increase the biologically active compounds in natural products. The research investigated the effects of acid HCE in a mice model of atopic dermatitis. The data obtained from this study sheds light on the use of hydrolysis methods to improve the biological activities of plant extracts used in nutraceutical industries.

Commiphora myrrha (Myrrh) is widely recognized for its anti-inflammatory and antimicrobial properties, which are utilized for the treatment of oral ulcers, gingivitis, sinusitis, glomerulonephritis, brucellosis and a variety of skin disorders. The current study aimed to assess whether myrrh modulates itch-associated interleukin (IL)-31 cytokine production and histamine release in stimulated human mast cells (HMC-1). To realize this, molecular biology techniques including real-time quantitiative PCR, western blotting and ELISA were employed. The results indicated that Myrrh successfully suppressed phorbol myristate acetate and calcium ionophore-stimulated mRNA expression, and reduced the production of IL-31 in HMC-1 cells. In addition, myrrh served as a suppressor of extracellular signal-regulated kinase and NF-κB activation, indicating its mechanism in the prevention of HMC-1 cell IL-31 production. Myrrh also prevented the release of histamine in HMC-1 cells. Whilst the present study awaits in vivo support, the pharmacological actions of myrrh provide new indications as to its potential applicability for itch treatment, which cannot be treated with histamine receptor blockers alone.

The present study demonstrated the anti-obesity effects of enzyme-treated celery extract (ECE) in mice on high-fat diet (HFD). In vitro studies showed that ECE has anti-adipogenic properties by inhibiting lipid accumulations in adipose cells. In vivo studies indicated that the administration of ECE markedly prevented HFD-induced body weight gain, food efficiency ratio, and epididymal fat and liver weights. ECE reduced lipid parameters, cardiac risk factor, and atherogenic index in obese mice. ECE prevented a diabetes state by improving adipokines levels, reducing glucose levels, and preventing insulin resistance. Moreover, ECE prevented HFD-induced liver damage by preventing hepatic steatosis and upregulation of liver antioxidant enzymes. The mechanism of ECE was partially investigated to involve the activation of 5' adenosine monophosphate-activated protein kinase and hence the downregulation of CCAAT/enhancer binding protein α and peroxisome proliferator-activated receptor γ by ECE. Our results suggest that ECE could be used as functional food materials for the prevention of obesity. PRACTICAL APPLICATIONS: Apium graveolens is a popular plant with nutritive and medicinal benefits. It contains bioactive compounds such as apiin, apigenin, and luteolin. However, these compounds are rendered insoluble due to their interaction with polysaccharides in the cell wall thus making them less bioavailable. Hydrolyzing them could increase the yield of bioactive compounds in celery. This pilot study demonstrates that pectinase-treated celery extract has anti-obesity effects. The results of this research demonstrate the use of enzymes in improving the biological activities of plant extracts and suggest the use of enzyme-assisted extraction techniques in the industrial production of health functional food from celery.

The anti-obesity effect of a combination of extracts made of Platycodon grandiflorum (PGE), Apium graveolens (AGE) and green tea (GTE) extracts was investigated in a high-fat diet-induced obese C57BL/6N mouse model. Body weight, epididymal adipose tissue weight, liver weight, adipocytes size and serum lipid profile, insulin, leptin and glucose levels were investigated. Additionally, hepatic steatosis, injury and oxidative burden were evaluated in the present study. The current study demonstrated that the PGE, AGE, and GTE (PAG) mixture were most effective in preventing obesity and its associated complications compared with the single extracts used alone. This was evidenced by the PAG's prevention of weight gain, reduction of adipocyte size, beneficial effects in serum lipid profile, levels of insulin, leptin and glucose, and the prevention of liver injury by reducing fat accumulation in the liver, decreased GOT and GPT enzymes and the upregulation of liver antioxidant enzymes. These results suggested that PAG may provide insights into functional food ingredients for use in the prevention of obesity.

OBJECTIVE: To find relationship between sleep breathing sounds and various polysomnographic features. METHOD: Patients who underwent PSG with audio recording using a microphone were included. After noise reduction preprocessing, the data were segmented into 5-second windows and sound features were extracted. A simple linear regression of various sound features were performed with various PSG features including apnea hypopnea index (AHI), apnea index (AI), hypopnea index (HI), Oxygen desaturation index (ODI), and respiratory arousal (RA). Also prediction of PSG features from sleep breathing sounds had been established using machine learning. RESULT: A total of 116 subjects were included. A total of 508 sound features were extracted. Among them, Derivative of Area Method of Moments Overall Standard Deviation was the most distinguishing feature that explained AHI (R2= 0.628), AI (R2=0.620), ODI (R2= 0.641), SpO2 CONCLUSION: Similar prediction values were acquired with simple linear regression and machine learning. Especially machine learning resulted in a better performance regarding to AI and Time of SpO2

IL-31 is a recently discovered cytokine that is produced not only in T-cells but also in mast cells. It is strongly implicated to play a key role in inflammatory diseases and in the pathogenesis of itch in atopic dermatitis. Apigenin, a flavonoid of plant origin has numerous biological applications. In this study, we showed that apigenin modulates IL-31 mRNA, protein expression, and release in stimulated human mast (HMC-1) by inhibiting the phosphorylation activation of MAPK and NF-&kappa, B. To determine whether apigenin has similar effects in vivo, using Compound 48/80, we developed an atopic dermatitis itch model in mice and found an increase in IL-31 expression in the skin. We also revealed that apigenin prevents the infiltration and degranulation of mast cells and suppressed mRNA and protein expression of IL-31 in the skin of mice. These results provide a new suggestion of the potential applicability of apigenin for treatment of various inflammatory diseases and itch mediated by IL-31.

A 2-year runoff plot study was conducted under simulated rainfall to explore the effects of no-till (NT) practice on the runoff ratio and NPS pollution in an intensive farming region of Korea. Eight 5 × 30 m runoff plots, four each on 3 and 8% slopes, were prepared in existing loamy sand fields. Cultivation in two plots on each slope followed conventional practice (CT). Six rainfall simulations were conducted during the study, each of a nominal 1 h duration and 30 mm h-1 intensity. The runoff ratio of the NT plots decreased 64.9% compared with that of the CT plots. The reduction of NPS pollution load by the NT treatment was 88.3% (SS), 79.0% (CODCr), 86.4% (CODMn), 66.4% (BOD), 67.6% (TN) and 73.6% (TP) compared to losses from the CT plots, with no reduction in average crop yield. Runoff reduction was a key factor in the reduction of pollution loads. The study demonstrated that agricultural NPS pollution loads can be significantly reduced by the application of no-till practice without harming crop productivity. Furthermore, NPS pollution loads can be controlled better if management practices are targeted for runoff reduction rather than concentration reduction. Copyright © 2016 John Wiley & Sons, Ltd.

The present study investigated the anti-atopic effects of mixed extracts from date plum, persimmon, and mulberry leaves (DPME) on atopic dermatitis (AD)-like skin lesions in hairless mice. The in vivo results demonstrated that DPME treatment significantly reduced the dermatitis clinical score and epidermal thickness in AD-like skin lesions. Histological analyses showed that DPME treatment strongly inhibited dermal infiltration of inflammatory cells and activity of mast cells in AD-like skin lesions. DPME treatment inhibited production of serum IgE and interluekin (IL)-4 in hairless mice with AD. Moreover, DPME treatment significantly suppressed production of tumor necrosis factor (TNF)-α and IL-6 cytokines in phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated HMC-1 human mast cells. In addition, DPME treatment reduced production of pro-inflammatory mediators (nitric oxide, prostaglandin E2, TNF-α, and IL-6) in lipopolysaccharide-stimulated RAW 264.7 macrophages. Therefore, the results of this study indicate that the anti-atopic and anti-inflammatory effects of DPME may be involved in the regulation of inflammatory responses, suggesting that DPME may be used as an anti-atopic dermatitis material and natural anti-inflammatory ingredient.

The calculation of lashing forces on containerships is one of the most important aspects in terms of cargo safety, as well as slot utilization, especially for large containerships such as more than 10,000 TEU (Twenty-foot Equivalent Unit). It is a challenge for stowage planners when large containerships are in the last port of region because mostly the ship is full and the stacks on deck are very high. However, the lashing force calculation is highly dependent on the Classification society (Class) where the ship is certified, its formula is not published and it is different per each Class (e.g., Lloyd, DNVGL, ABS, BV, and so on). Therefore, the lashing result calculation can only be verified by the Class certified by the Onboard Stability Program (OSP). To ensure that the lashing result is compiled in the stowage plan submitted, stowage planners in office must rely on the same copy of OSP. This study introduces the model to extract the features and to predict the lashing forces with machine learning without explicit calculation of lashing force. The multimodal deep learning with the ANN, CNN and RNN, and AutoML approach is proposed for the machine learning model. The trained model is able to predict the lashing force result and its result is close to the result from its Class.

IL-31 and IL-33 are cytokines, which are expressed in many inflammatory and pathological disorders, thus suggesting an IL-31/IL-33 axis interaction in pathological diseases. Luteolin from natural products is known for its anti-inflammatory activities associated with the regulation of inflammatory signaling pathways. Here, we investigated the effects of luteolin in the regulation of IL-33-stimulated production and secretion of IL-31 in HMC-1.2 mast cells. Human mast cells (HMC-1.2) were treated with luteolin and stimulated with IL-33. Real-time PCR was used to measure IL-31 mRNA expression. Western blot and immunofluorescence assays were used to measure IL-31 expression. ELISA techniques were used to measure IL-31 secretion and NF-κB-DNA-binding activities. The results revealed that luteolin inhibited the expression of IL-31 in IL-33-stimulated HMC-1.2 cells at the mRNA and protein levels. Also, Luteolin inhibited the secretion of IL-31 into the cell culture media of the IL-33-stimulated HMC-1.2 cells. Further findings demonstrated that luteolin inhibited the activation of ERK, JNK, p38, and NF-κB p65 in the IL-33-stimulated HMC-1.2 cells. In addition, luteolin also prevented the nuclear translocation and binding of p65 to its DNA-binding site. Based on the results, luteolin may be considered as a potential therapeutic or functional food agent for the prevention and/or treatment of IL-31 and IL-33-related diseases.

Nonalcoholic fatty liver disease (NAFLD) corresponds to hepatic manifestations of inflammation and accumulations of fatty acids in the liver. Recently, IL-17 signaling pathways have been shown to contribute to the pathogenesis of NAFLD. Cirsium japonicum var. ussuriense is often used in treatment of human diseases such as hemorrhage, blood congestion and inflammation. Despite the known biological activities of C. japonicum var. ussuriense, its effect on NAFLD is still unknown. Here, we investigated the effects of C. japonicum var. ussuriense extract (CJE) and cirsimaritin, its main constituents, on high-fat diet (HFD) or oleic acid (OA)-induced IL-17 expressions associated with steatohepatitis. We found that the levels of IL-17 was reduced in OA-treated HepG2 cells and in mice fed with HFD and administered with CJE and cirsimaritin at the mRNA, protein, and serum expression levels. Further investigation showed that CJE and cirsimaritin suppressed MAPK and NF-κB, the key signaling pathway responsible for IL-17 expression in HFD-fed mice and OA-treated hepatocytes, thus suggesting that the action of CJE and cirsimaritin on signaling molecules might have been responsible for the suppression of IL-17. Here, we also demonstrated that administration of CJE and cirsimaritin reduced triglyceride, aspartate aminotransferase, alanine aminotransferase, and malondialdehyde levels in OA-treated HepG2 cells; and protected mice against HFD-induced triglyceride, aspartate aminotransferase, alanine aminotransferase, and malondialdehyde levels. The results collectively demonstrate that CJE and cirsimaritin may protect against IL-17 exacerbated HFD-induced steatohepatitis.

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Seung Jin Hwang, Yun Sun Kim, Yoo Mi Kim, So Yeon Gil, Mu Hyun Jin, and Sang Hwa LeeSkin Research Center, Research Park, LG Household & Healthcare Ltd., 84 Jang-dong, Youseong-gu, Daejeon 305-343, Korea(Received November 16, 2015; Revised December 9, 2015; Accepted December 11, 2015)요 약: 피부는 외부 유해물질로부터 내부기관을 보호하는 장벽기능을 하는 대표적인 기관으로 자외선(ultraviolet radiation, UV), 중금속, 각종 산화 물질들과 같은 외부의 위협에 항상 노출되어 있어 손상을 받기 쉽다. 특히 자외선 B (UVB)는 진피의 상부까지 도달하여 화상이나 홍반과 같은 염증반응을 일으키며 멜라닌 생성을 촉진시켜 색소 침착을 유발한다. 지나친 자외선 B의 피부세포로의 유입은 각질세포 및 진피 섬유아세포의 DNA손상을 야기하고, 세포외기질의 합성을 방해하여 피부탄력감소, 주름생성, 진피 결합조직의 손상과 함께 피부장벽을 붕괴시켜 노화를 일으키며, 장기간 노출 시 심각한 피부 병변으로 이어져 피부세포 사멸 및 종양의 발생으로까지 이어진다. Haloarcula vallismortis는 사해로부터 분리 동정한 미생물로 호염성 고생물의 생장적 특징은 아직 자세히 연구된 바는 없다. 대게 10% 이상의 염도에서 자라는데 실제 생장염도는 평균 20 ∼ 25% 염도에서 자란다. 염도가 높은 호수나 염전에서 주로 발견되기 때문에 강한 햇빛에 대한 방어기작이 존재한다. 그중 하나로 다른 ATP를 생성하기 위한 bacteriorhodopsin외에 halorhodopsin이라는 색소를 이용, 광자(photon)를 흡수하고 염화이온 채널을 개방시켜 생기는 전위차를 이용해 추가로 에너지를 생산한다. 또 carotenoid 색소로 인해 농도가 높을시 분홍색 또는 빨간색을 띄는 특징이 있는데 이것이 강한 자외선에 대한 방어기작을 할 것이라고 여겨진다. 본 연구는 호염성 고세균이 자외선을 에너지 소스로 이용하는 특성을 이용하여 자외선으로부터 피부를 방어하는 방법을 개발하고자 이들의 피부각질세포에서 자외선에 의한 항염 효과 및 DNA 손상 방어 효과를 확인하였다. 그리고 이들을 천연 자외선 차단제의 소재로서 사용 할 수 있음을 확인하였다.Abstract: Skin carrys out protective role against harmful outer environment assaults including ultraviolet radiation, heavy metals and oxides. Especially, ultraviolet-B (UVB) light causes inflammatory reactions in skin such as sun burn and erythma and stimulates melanin pigmentation. Furthermore, the influx of UVB into skin cells causes DNA damage in keratinocytes and dermal fibroblasts, inhibition of extracellular matrix (ECM) synthesis which leads to a decrease in elasticity of skin and wrinkle formation. It also damages dermal connective tissue and disrupts the skin barrier function. Prolonged exposure of human skin to UVB light is well known to trigger severe skin lesions such as cell death and carcinogenesis. Haloarcula vallismortis is a halophilic microorganism isolated from the Dead Sea, Its growth character-istics have not been studied in detail yet. It generally grows at salinity more than 10%, but the actual growth salinity usually ranges between 20 to 25%. Because H. vallismortis is found mainly in saltern or salt lakes, there could exist defense mechanisms against strong sunlight. One of them is generation of additional ATP using halorhodopsin which

Purpose. This trial was performed to investigate the efficacy of laser acupuncture for the alleviation of lower back pain.Methods. This was a randomized, placebo-controlled, double-blind trial. Fifty-six participants were randomly assigned to either the laser acupuncture group (n=28) or the sham laser acupuncture group (n=28). Participants in both groups received three treatment sessions over the course of one week. Thirteen acupuncture points were selected. The visual analogue scale for pain, pressure pain threshold, Patient Global Impression of Change, and Euro-Quality-of-Life Five Dimensions questionnaire (Korean version) were used to evaluate the effect of laser acupuncture treatment on lower back pain.Results. There were no significant differences in any outcome between the two groups, although the participants in both groups showed a significant improvement in each assessed parameter relative to the baseline values.Conclusion. Although there was no significant difference in outcomes between the two groups, the results suggest that laser acupuncture can provide effective pain alleviation and can be considered an option for relief from lower back pain. Further studies using long-term intervention, a larger sample size, and rigorous methodology are required to clarify the effect of laser acupuncture on lower back pain.

Ten compounds (1-10) isolated from the seeds of Cassia tora were evaluated for tyrosinase inhibition. Compounds 3, 4, and 7 inhibited tyrosinase enzymatic activity in a dose-dependent manner, with IC50 values of 3.0 ± 0.8, 7.0 ± 0.4, and 9.2 ± 3.4 μM, respectively. Kinetic analyses revealed a mechanism consistent with competitive inhibition. In silico molecular docking showed that compounds 3 and 4 docked in the active site of tyrosinase, whereas 7 interacted with Ala246 and Val248 at outside of the active site, and His244 and Glu256 at inside. Additionally, compounds 3, 4, and 7 suppressed melanogenesis in α-MSH-treated B16F10 melanoma cells at a concentration of 10 μM.

Nanoscale Sn-Bi-Ag compound powders were successfully synthesized using the pulsed wire discharge (PWD) method. In PWD, when a high current is passed through high-density metal wires, the wires explode because of resistance heating, forming fine particles or metal vapor. In this study, we used Sn-Bi and Ag wires in order to obtain three-component nanopowders. A high current was applied to the wires between the electrodes in a N2 atmosphere. We discussed the results based on the K factor, which is the ratio of the charging energy of the capacitor to the vaporization energy of the wire. The three-component (Sn-Bi-Ag) nanoparticles were synthesized under a N2 atmosphere at 4 and 6 kV. From the particle-size distribution curves, it was found that the mean particle diameter (D1) values of the Sn-Bi and Ag nanopowders were within the range of 16.32-42.37 nm under each condition. The melting point of the Sn-Bi-Ag nanoparticles was found to be within the range of 188.68-214.97 ℃, which is about 40 ℃ lower than that obtained from the phase diagram and computational thermodynamics of the Sn-Bi-Ag system. In this study, the nanopowders were obtained by subjecting the wires at extreme energies, to improve their solid solubility. (Received February 8, 2017; Accepted July 26, 2017)

This study analyzed fruit stem extract (MGFE) from Muscat Bailey A grape (Vitis labrusca × Vitis vinifera) for their ameliorative effects on Ultraviolet B (UVB)-induced skin damage in Balb/c mice. Well established in vivo assays were used to determine the biological effects of MGFE upon UVB irradiation of BALB/c mice. The results showed that treatment with MGFE recovered glutathione depletion, prevented lipid peroxidation of tissues and decreased the expression of DNA repair enzyme oxo guanine glycosylase-1. MGFE recovered the skin conditions in UVB-irradiated Balb/c mice. Moreover, MGFE inhibited dermal infiltration of inflammatory cells and reduced serum tumor necrosis factor alpha and interleukin-6 levels. Finally, MGFE treatment inhibited UVB-induced melanin formation and collagen fiber destruction through the inhibition of matrix metalloproteinase-1 expression. Through high-performance liquid chromatography analysis, catechin, epicatechin, and trans-resveratrol were found to be among the main active compounds present in MGFE. Taken together, these results indicated that MGFE has potentials as topical therapeutic materials against skin damage by inhibiting oxidative stress and inflammatory.

지속적인 유가 상승과 탄소배출 규제 강화는 기업들로 하여금 높은 경쟁력을 가지도록 요구한다. 따라서 고객 서비스 증대와 비용절감을 위해 효율적인 물류시스템을 구축하고 운영하는 것에 많은 노력을 기울이고 있으며 비용 경쟁력을 가지는 친환경 산업단지의 필요성이 증대되고 있는 실정이다. 부산시에서는 친환경정책을 통해 경쟁우위를 점하고 부족한 산업단지를 충족시키기 위해 서부산권에 '부산신항배후 국제산업물류도시'를 선정하고 개발을 진행하고 있다. 이러한 산업단지를 구축하기 위해서는 적절한 정책과 화물수송 공동화를 통한 물류시스템이 필요하다. 특히, 산업 단지내 물류시스템의 체계구축을 통한 효율적인 운영은 저비용 친환경적인 측면에서 매우 중요하다. 따라서 본 연구에서는 물류체계를 분석하고 분석내용을 바탕으로 물류네트워크 운영모델을 제시함으로서 산업단지의 기반을 마련하는데 목적이 있다. 【Companies are facing challenges to have high competitiveness because of continuous oil price rising and CO2 emissions regulations. Thus, companies are trying hard to construct effective logistics and operation system to achieve high customer service quality and saving cost. Also the ec-friendly idustrial complex is needed. Busan is in process to construct GILC(Global Industry Logistics City) in west Busan province to achieve high competitiveness and support lack of industrial complex. To construct this kind of logistics industrial complex, it needs logistics system through proper policy and freight transportation co-operation. Especially, efficient management through logistics hierarchy construction in industrial complex is very important for low cost and eco-friendly point of view. Therefore, this paper aims to analyze logistics system and suggest operation model to present logistics complex construction base data.】

Background: Degenerative lumbar spinal stenosis is one of the most common causes of chronic lower back pain and radiculopathy. Spinal stenosis is anatomically classified as central and lateral spinal canal stenosis. Many treatment modalities and techniques, including surgery and epidural injection, have been used to manage the pain. However, the effect of hypertonic saline injection via the transforaminal approach has not yet been studied. Objectives: The aim of this study is to determine the effect of adding hypertonic saline to conventional transforaminal epidural steroid injections (TFEI) to provide pain relief for chronic radiculopathy patients secondary to lateral canal spinal stenosis. Study Design: A double-blind, randomized, active-control trial. Setting: An interventional pain management practice in a hospital, Republic of Korea. Methods: Two groups: the hypertonic group received hypertonic saline combined with triamcinolone and the control group received normal saline combined with triamcinolone. A total of 68 patients were randomly allocated into either 2 groups by a computergenerated randomization program. Twenty-seven patients in the hypertonic group and 26 patients in the control group were assessed. A total of 53 patients were included in this analysis. Outcome measures were taken at baseline, one, 2, 3, 4, and 6 months postprocedure. The primary outcome measures included the numerical rating scale (NRS) and the proportion of substantial responders. The secondary outcome measures included the Oswestry disability index (ODI), the proportion of substantial and moderate responders, and patient satisfaction. Results: Transforaminal epidural injection of steroids, with or without the addition of 10% hypertonic saline, was effective and provided significant pain relief with the improvement of functional outcome within 4 months. The addition of hypertonic saline was superior in efficacy compared with conventional TFEI at 3 months follow-up. The differences in the absolute pain scores did not demonstrate statistical significance between the 2 groups. The reduction in pain intensity from the baseline was greater in the hypertonic group and demonstrated higher rates of satisfaction. The use of hypertonic saline also extended the duration of significant pain relief to 6 months compared with baseline. Limitations: The lack of placebo group and small sample size. Conclusion: Superior short-term pain relieving efficacy, but limited long-term effects of hypertonic saline, when added to TFEIs. Key words: Chronic pain, lumbar radiculopathy, lateral canal, spinal stenosis, transforaminal, epidural steroid injections, hypertonic saline, local anesthetic

The objective of the research was to describe the effect of straw mat cover and soil amendments on the reduction of runoff and non-point source load from steep sloped highland agricultural fields. Four m plots on sandy loam soil with 28 % slope were prepared. Experimental treatments were bare (control), rice straw mat cover (3,000 kg/ha) (S), PAM (5 kg/ha)+Gypsum (1 ton/ha) (PG) and rice straw mat cover+PAM+Gypsum (SPG). A variety of lettuce was cultivated and runoff was monitored during a growing season in 2011. Natural monitoring was conducted to three times. Runoff rate of S, PG and SPG plots were significantly lower than those of control plot. Especially, the runoff rate is zero in SPG plot at a first rainfall events. The reduction rate of runoff from the S, PG and SPG plots was 30.8 %, 29.0 % and 81.8 % compared to control plots, respectively. The reduction rate of NPS pollution load of S, PG and SPG was ranged of 50~90 %, 30~70 % and 90~100 %, respectively. Yield of lettuce from S, PG and SPG plots was respectively 400 (567 kg/ha), 320 (453 kg/ha) and 760 (1,067 kg/ha) that of compared to control plots greater than that from control plots (140 kg/ha). We speculated that the experimental treated plots could hold more nutrients and moisture than the control and helped the crop grow healthier. When analyzing the above results, in terms of reduction of runoff and NPS pollution load and crop yields, SPG experimental treatment had the best effect. It was concluded that the use of rice straw mats cover and soil amendments on soil surface could not only reduce the NPS pollution loads in receiving waters but also help increase the crop yield.

The purpose of this survey was to document the experience of Korean Medicine doctors (KMD) who provided postoperative care to patients through integrative medicine and to understand their opinions about integrative medicine utilization. Three researchers (two with a KMD license) of the Korea Institute of Oriental Medicine conducted the survey. The questionnaire was distributed via e-mail to the 17,041 members of the Association of Korean Medicine in 2015. In total, 487 KMD answered the questionnaires. The majority of respondents worked in a Korean Medicine (KM) clinic, KM hospital, or long-term care hospitals (94.7%). The respondents mostly treated patients after musculoskeletal (26.7%), spinal (23.7%), or neuropathic surgery (22.2%). Patients predominantly experienced pain (23.0%), fatigue and tiredness (17.4%), delayed scar recovery (13.7%), and paralysis (13.0%). We analyzed subgroups in accordance with institution of employment, specialization, and clinical experience. Most KMD wanted to utilize integrative medicine for postoperative care of patients (92.6%). Moreover, a relatively active collaboration was noted in long-term care hospitals (mean rate: 60.73% [95% CI: 42.25 to 79.20]). Further studies and clinical trials are needed to determine whether integrative medicine is essential for providing postoperative care to Korean patients.

Background Radial pressure pulse wave (RPPW) examination has been a key diagnostic component of traditional Chinese medicine. The objective of this study was to investigate the changes in RPPW along with various hemodynamic variables after acupuncture stimulation and to examine the validity of pulse diagnosis as a modern diagnostic tool. Methods We conducted acupuncture stimulation at both ST36 acupuncture points in 25 healthy volunteers. We simultaneously assessed the RPPW by pulse tonometry; heart rate variability (HRV) by electrocardiogram; photoplethysmogram (PPG) signals, respiration rate, peripheral blood flow velocity and arterial depth by ultrasonography; and cardiac output by impedance cardiography, before, during and after a session of acupuncture stimulation. Results We observed consistent patterns of increased spectral energy at low frequency (

An upland monitoring was conducted for about 4 years with respect to the water and quality of rainfall-runoff. The objective was to characterize of runoff and nonpoint source (NPS) pollution from a sandy field with 4.5 % in slope under balloonflower (2008-2010) and potato (2011) cultivation. Balloonflower was cultivated without any surface cover but potato was grown under plastic mulching. Runoff rate, EMCs and NPS pollution loads were estimated. The first flush effect was evaluated, and the correlation coefficient among the selected water quality indices were analyzed. Average rainfall size was higher by 2.3 mm when balloonflower was cultivated but average runoff rate was higher by 0.02 when potato was cultivated due to the plastic mulching. EMCs monitored from balloonflower field were higher than potato field except SS and TN, but all NPS pollution loads of potato field were 2.1~22.9 times greater than balloonflower field because of larger runoff volume. As a result of first flush effects, balloonflower and potato field were more influenced by increasing of accumulated rainfall and rainfall intensity rather than first flush. In the result of correlation analysis, there were no evident correlations between runoff and water quality indices. However, there were obvious correlations between SS and the other indices except TN. As a result of this study, it was thought that perennial balloonflower crop could help reduce runoff and NPS pollution loads but annual crop with plastic mulching increase them.

We measure the hemodynamic responses during the 4 kinds of tasks on the motor cortex in the right and left human brain by using near-infrared spectroscopy. The experimental results show that the change of concentration of oxy-hemoglobin is larger than that of deoxy-hemoglobin and the change of concentration of chromophores induced by finger and arm related task show more activations than that of leg.

This paper presents a comparison of potential and viscous computational codes for the water entry problem. A po-tential code was developed which adopted the boundary element method to solve the problem. A nonlinear free surface boundary condition was integrated to find new locations of free surface. The dynamic boundary condition was simplified by taking constant potential values for every time steps. The simplified dynamic boundary condition was applied in the new position of the free surface not at the mean level, which is the usual practice for linearized theory. The commercial code FLUENT was used to solve the water entry problem from the viscosity point of view. The movement of the air-liquid interface is traced by distribution of the volume fraction of water in a computational cell. The pressure coefficients were compared with each other, while experimental results published by other researchers were also examined. The characteristics of each method were discussed to clarify merits and limitations when they were applied to the water entry problems.

To measure effects of surface cover on runoff and sediment discharge reduction using rainfall simulator, four(5 m30 m scale) plot experiments were conducted in this study. Surface covers made with straw mat, Polyacrylamide (PAM), chaff, and sawdust were simulated 4 times under 31.1~44.4 mm/hr rainfall intensities. Compared with results from control plot, the time of runoff generation is delayed and outflow volume decreased with surface cover. Effects on runoff reduction of straw mat, PAM, sawdust and chaff ranged 4.7~81.5 % and runoff rate reduced by 6.5~76.1 % respectively, when compared with those from control plot. The percentage of decrease in sediment discharge were 99.7~99.8 % from straw mat+sawdust+PAM plots, 85.9~95.6 % from straw mat+PAM plots, and 98.5~99.4 % from straw mat+chaff+PAM plots. The runoff, sediment discharge, and SS concentration reduction efficiencies of the cover materials were outstanding when compared to control plot. It was analyzed that reduction of runoff and sediment discharge were mainly contributed by decrease in rainfall energy impact and flow velocity and increase of infiltration due to the surface cover materials. The results could be used as a base for the development of best management practices (BMPs) to reduce runoff, sediment discharge from sloping field.

An attempt was made to compute the free surface deformation due to the impact of a water droplet. The Cauchy Poisson, i.e. the initial value problem, was solved with the kinematic and dynamic free surface boundary conditions linearized. The zero order Hankel transformation and Laplace transform were applied to the related equations. The initial condition for the free surface profile was derived from a captured video image. The effect of the surface tension was not significant with the water mass used in this investigation. The computed and observed free surface deformations were compared.

Recently, container terminal managers make an experiment on the double cycle and dual cycle operation, which ship loading and unloading were carried out simultaneously, for increasing the productivity of quay side. If, however, we make an experiment on dual cycle operation in a real job site, the efficiency is poor up to terminal operation method as YTs(Yard Tractors)` allocation method, QCs(Quay Cranes)` working speed, and position of export containers. Especially, using the existing yard operation method, it is difficult to support to dual and double cycle operation. Therefore, this paper examine more efficient terminal operation method, when terminal uses dual cycle operation. We developed a simulation model using simulation analysis software, Arena.

We analyze the channel capacity with considering the effect of the loading conditions of indoor PLC networks on channel state information. We consider various numbers of load for two kinds of the networks with regular length branches and a deployed network of indoor PLC. For calculating the channel capacity degradation, two noise scenarios and impedances are considered. From the simulation results, we suggest the robust regression lines for modeling the channel capacity degradation. In the cases of 0 and loads, natural log and linear function curve show the best goodness of fit, respectively. For the deployed indoor PLC network with 0 loads, compared with the networks with regular length branches, the goodness of fit decreases by the amount of 0.12 and 0.15 for low noise and high noise scenarios, respectively. Using the regression lines, we can estimate the channel capacity degradation without measurement.

Introduction:About 55% to 75% of stroke survivors have motor disorders and problems that affect their quality of life. The prevention of secondary neurological damages through relapse prevention and the rehabilitation of stroke patients suffering from morbidities are crucial to improve the p

*Hutchison Korea Terminals, Busan 601-050, Korea**,†Department of Logistics Engineering, Korea Maritime University, Busan 606-791, Korea***Graduate school of Korea Maritime University, Busan 606-791, Korea요 약 :오늘날의 전반적인 산업분야에서는 정보기술을 바탕으로 운영되고, 이에 대한 투자가 증가되고 있다. 물류산업에서도 물류정보망의 중요성이 커지고, 효율적으로 운영하기 위한 정보화 투자가 증가되고 있다. 효율성에 관한 기존연구에서는 설비와 같은 고정자산만을 고려한 효율성 분석으로 이루어져, 정보화 수준이 효율성에 미치는 영향에 관한 연구는 미흡하다. 본 연구는 컨테이너 터미널 효율적 운영을 위하여 정보화 수준을 고려한 효율성 분석의 중요성을 제시하고, DEA과 Bootstrap를 이용하여 정보화 수준과 관련된 상대적 효율성을 측정하였다. 핵심용어 : 컨테이너터미널, DEA, 정보화 수준, 효율성분석, 부트스트랩Abstract :Today, overall industry has been operated on the basis of information technology and has increased the investment on it. In the logistics industry, the integrated material handling information network has become important more and more and the investment on the informatization has been increased to operate efficiently. In the previous literature, most of the measures for the efficiency of container terminals were the variables such as fixed assets of equipments. There has not been any research effort toward examining the effect of informatization level on the efficiency. This work describes the importance on the efficiency evaluation considering the informatization level to in a container terminal and the relative efficiency level is measured using data envelopment analysis and bootstrap. Key words :Container Terminal, Informatization Level, Efficiency analysis, DEA, Bootstrap * 대표저자(정회원) : 최봉환, itcbh@hktl.com 051)630-8251 ** 정회원, shinjy@hhu.ac.kr 051)410-4335*** 정회원, twu04@nate.com 051)410-4930 †교신저자 : 신창훈(정회원), chshin@hhu.ac.kr 051)410-4930

*Graduate school of National Korea Maritime University, Busan 606-791, Korea†Dept. of Logistics Engineering, National Korea Maritime University, Busan 606-791, Korea요 약 :컨테이너 터미널의 주요 생산성 지표는 안벽에서의 작업 효율성이라 할 수 있다. 안벽에서는 Q/C(Quay Crane)이라는 장비가 접안 선박의 컨테이너를 하역한다. Q/C의 작업 생산성을 높이기 위해서는 좀 더 효율적인 Y/T(Yard Tractor)운영 방식이 필요하다. 기존 작업 방식(싱글 사이클)에서는 양하작업 이후 적하 작업이 이루어진다. 듀얼 사이클이란 양하작업과 적하 작업을 동시에 함으로써 안벽 생산성과 야드 트랙터의 이용률을 높이는 방법이다. 터미널에서 듀얼 사이클의 도입은 추가적인 장비의 도입 없이 운영에서의 변화만을 요구한다. 즉, 기존의 dedicate 시스템에서 pooling 시스템으로의 변화가 필요하다. 본 논문에서는 듀얼 사이클을 이용하는 항만에서의 작업 효율성을 증대시키기 위한 선적 계획 방법을 제시하고자 한다. 이 문제를 풀기위해 유전 알고리즘과 타부서치를 제시하였다.핵심용어 : 컨테이너 터미널, 더블 사이클, 듀얼 사이클, 크레인 일정계획, 유전 알고리즘, 타부 서치Abstract :At container terminals, a major measurement of productivity can be work-efficiency in quay-side. At the apron, containers are loaded onto the ship and unloaded to apron by Q/C(Quay Crane). For improving the productivity of quay crane, the more efficient Y/T(Yard Tractor) operation method is necessary in container terminals. Between quay-side and yard area, current transferring methods is single-cycling which doesn't start loading unless it finishes unloading. Dual-cycling is a technique that can be used to improve the productivity of quay-side and utility of yard tractor by ship loading and unloading simultaneously. Using the dual-cycling at terminals only necessitates an operational change without purchasing extra equipment. Exactly, Y/T operation method has to be changed the dedicate system to pooling system. This paper presents an efficient ship loading and unloading plan in container terminals, which use the dual-cycling. We propose genetic and tabu search algorithm for this problem.Key words :container terminal, double cycle, dual cycle, crane scheduling, genetic algorithm, tabu search* 대표저자 : 정창윤(정회원), ccy1443@hhu.ac.kr 010-6400-7974†교신저자 : 신재영 shinjy@hhu.ac.kr 051)410-4335

Generally, the container road transportation can be divided into three types; short distance, long distance and shuttle transportation. Specially, the shuttle service occurs several amounts of container which is same as O/D pairs. Also container vehicle can be divided into three types according to the chassis types of vehicle; only 20-feet container, only 40-feet container and combined chassis trailer. Combined chassis trailers can load two 20-feet containers or one 40-feet container. This paper deals with Vehicle Routing Problem (VRP) for delivering containers considering shuttle service. This problem is similar to the previously studied Shin and Oh (2008), but the characteristics of shuttle service must be considered additionally. We formulate the container shuttle transportation planning problem using combined chassis trailers based on VRP with pick-up and delivery which can visit each node more than one time, and propose an efficient solution procedure.

The improvement in the terminal productivity plays a key role for container terminals to be more competitive. The productivity of yard tractors(YT) is one of the most important factor accelerating the terminal productivity. Thus, YT pooling system is newly introduced in container terminals for increasing the YT productivity. Recently, the terminals in Korea tend to adopt YT pooling system. This paper proposes the important decision factors for YT pooling work space and several types of formulations according to states of container terminals.

This study was conducted to estimate heritabilities and genetic correlations among carcass weight and body type measurements (Wither height, Rump height, Body length, Chest depth, Chest width, Rump length, Rump width, Thurl width, Hipbone width, Chest girth) obtained from 1,587 records of Hanwoo steers in National Hanwoo Contest. Based on EM-REML algorithm, this study estimated genetic parameters of the carcass weight and body type measurements that greatly affect Hanwoo's carcass grade and body type. The means and standard deviations of each trait were 377.30±45.59 kg , 136.14±4.51 cm , 137.79±4.62 cm , 157.77±6.97 cm , 77.55±3.62 cm, 51.72±4.30 cm , 55.04±3.19 cm , 50.21±2.96 cm , 48.29±2.94 cm , 29.12±2.04 cm , and 217.31±11.36 cm for Carcass weight, Wither height, Rump height, Body length, Chest depth, Chest width, Rump length, Rump width, Thurl width, Hipbone width and Chest girth, respectively. As a result of analysis on the effects by the birth year, the Carcass weight, Wither height, Rump height, Body length, Chest depth, Chest width, Rump length, Rump width, Thurl width, and Chest girth came out highest as 413.4±37.5 kg , 138.4±4.1 cm , 139.9±4.3 cm , 162.1±5.7 cm , 80.8±2.5 cm , 55.3±3.7 cm , 58.0±3.3 cm , 52.9±2.4 cm , 50.9±2.8 cm and 225.9±8.3 cm , respectively in 2005. As a result of analysis on the effects by the birth season, the carcass weight and body type measurements came out highest, respectively in spring. As a result of the analysis on the effects by the birth location, all of the traits came out highest, respectively in Gangwon. In the majority of carcass weights and body type measurements, statistically significant differences were observed depending on the location of birth. The heritabilities of the carcass weight, chest width and chest girth were estimated as 0.242, 0.221 and 0.264 respectively. These heritabilities of such traits were higher than those of other traits (withers height, rump height, body length etc.). Genetic correlation coefficients were estimated to be 0.944 between wither height and rump height, 0.822 between carcass weight and chest width, 0.769 between carcass weight and chest girth. From the results above, if the carcass weight should be improved by body type measurements of Hanwoo steer, it seemed that such factors as, chest width, chest girth, body length and withers height, which have relatively higher genetic correlations with carcass weight, should be considered.

A transient three-dimensional, single-phase and non-isothermal numerical model of polymer electrolyte membrane (PEM) fuel cell with high operating temperature has been developed and implemented in computational fluid dynamic (CFD) code. The model accounts for transient convective and diffusive transport, and allows prediction of species concentration. Electrochemical charge double-layer effect is considered. Heat generation according to electrochemical reaction and ohmic loss are involved. Water transportation across membrane is ignored due to low water electro-osmosis drag force of polymer polybenzimidazole (PBI) membrane. The prediction shows transient in current density which overshoots (undershoots) the stabilized state value when cell voltage is abruptly decreased (increased). The result shows that the peak of overshoot (undershoot) is related with cathode air stoichiometric mass flow rate instead of anode hydrogen stoichiometric mass flow rate. Current is moved smoothly and there are no overshoot or undershoot with the influence of charge double-layer effect. The maximum temperature is located in cathode catalyst layer and both fuel cell average temperature and temperature deviation are increased with increasing of current load.

Introduction: This study aims to investigate the effects of acupuncture stimulation on the radial artery’s pressure pulse wave, along with various hemodynamic parameters, and to explore the possible underlying mechanism of pulse diagnosis in healthy participants in their twenties. Methods and analysis: This study is a prospective, single-arm, exploratory clinical study. A total of 25 healthy participants, without regard to gender, in their twenties will be recruited by physicians. Written informed consent will be obtained from all participants. The participants will receive acupuncture once at ST36 on both sides. The radial arterial pulse waves will be measured on the left arm of the subjects by using an applicable pulse tonometric device (KIOM-PAS). On the right arm (appearing twice), electrocardiogram (ECG), photoplethysmogram (PPG), respiration and cardiac output (CO) signals, will be measured using a physiological data acquisition system (Biopac module), while the velocity of blood flow, and the diameter and the depth of the blood vessel will be measured using an ultrasonogram machine on the right arm (appearing twice). All measurements will be conducted before, during, and after acupuncture. The primary outcome will be the spectral energy at high frequencies above 10 Hz (SE10-30Hz) calculated from the KIOM-PAS device signal. Secondary outcomes will be various variables obtained from the KIOM-PAS device, ECG, PPG, impedance cardiography modules, and an ultrasonogram machine. Discussion: The results of this trial will provide information regarding the physiological and the hemodynamic mechanisms underlying acupuncture stimulation and clinical evidence for the influence of acupuncture on the pressure pulse wave in the radial artery. Ethics and dissemination: This study was approved by the Institutional Review Board (IRB) of Kyung Hee University’s Oriental Medical Center, Seoul, Korea (KOMCIRB-150818-HR-030). The study findings will be published in peer-reviewed journals and presented at national and international conferences. Trial registration number: This trial was registered with the Clinical Research Information Service (CRIS) at the Korea National Institute of Health (NIH), Republic of Korea (KCT0001663), which is a registry in the World Health Organization’s (WHO’s) Registry Network.

When the freight is loaded into a container loading rate must be considered. There are many studies on loading more freights into limited space. But the problem, which is needed to consider the routing sequence is different. A large size of freights, such as shipbuilding materials, am be rehandled or cannot be possible to unload. In this paper I tried to find the solution for the problem consider routing sequence, whereupon I present the container loading model which consider the routing sequence and loading rate and its solution.

This study deals with some practical problems of the container road transportation in Korean trucking industries. We examine the workflow in container transportation and then develop mathematical models integrating the various operating and design characteristics of the containers. Several types of formulations are developed utilizing the standard formulations of well known TSP (Traveling Salesman Problem) and VRP (Vehicle Routing Problem). Heuristic algorithms are also presented to solve the models. An example problem is illustrated to explain how to apply the models to the real world through the data set collected from a container trucking company in Korea.