51. Biocompatibility and Osseointegration of Titanium Implants with a Silver-Doped Polysiloxane Coating: An In Vivo Pig Model.
- Author
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Smeets, Ralf, Precht, Clarissa, Hahn, Michael, Ole Jung, Hartjen, Philip, Heiland, Max, Gröbe, Alexander, Holthaus, Marzellus große, and Hanken, Henning
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BIOCOMPATIBILITY ,OSSEOINTEGRATION ,DENTAL implants ,SILOXANES ,TITANIUM ,ANIMAL experimentation ,BIOMEDICAL materials ,SWINE ,IN vivo studies - Abstract
Purpose: To test the antimicrobial properties, surface topography, reaction of surrounding tissue (biocompatibility) and osseointegration of ultrathin implant surfaces containing polysiloxane and nanoscaled silver particles. Materials and Methods: Implants with polysiloxane coating and nanoscaled silver particles (Ag/SiO
x Cy ; HyProtect, Bio-Gate) were compared with implants with polysiloxane coating alone and with noncoated (grit-blasted and acid-etched) implants. A total of 72 implants were inserted into the calvaria of eight domestic pigs (nine implants each, three of each type). After 3 months, histologic sections were evaluated for inflammatory cell infiltration and bone implant contact. Results: Roughness parameters did not differ between all three implant types. The Ag/SiOx Cy coating exhibited a good antimicrobial effect in vitro and no sign of inflammatory cell infiltration in vivo. The noncoated implants demonstrated 10.85% and 14.48% more bone contact than the polysiloxane-coated implants (P = .003) and the Ag/SiOx Cy -coated implants (P ⩽ .001), respectively. Osseointegration was not significantly different between the Ag/SiOx Cy -coated and polysiloxane-coated implants (P = .72). Conclusion: The osseointegration capability of the Ag/SiOx Cy -coated implants was equal to that of the polysiloxane-coated implants but less than that of the grit-blasted and acid-etched implants. Because of the biocompatibility of the polysiloxane coating, further studies should be conducted in load-bearing models and in the oral cavity to investigate the antimicrobial effect of the embedded silver clusters. [ABSTRACT FROM AUTHOR]- Published
- 2017
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