186 results on '"Humburg, P."'
Search Results
52. Aquatic macroinvertebrate association with willow wetlands in northeastern Missouri
- Author
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Magee, Patrick A., Fredrickson, Leigh H., and Humburg, Dale D.
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- 1993
- Full Text
- View/download PDF
53. NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease
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Schwerd, T., Bryant, R. V., Pandey, S., Capitani, M., Meran, L., Cazier, J. -B., Jung, J., Mondal, K., Parkes, M., Mathew, C. G., Fiedler, K., McCarthy, D. J., Sullivan, P. B., Rodrigues, A., Travis, S. P. L., Moore, C., Sambrook, J., Ouwehand, W. H., Roberts, D. J., Danesh, J., Russell, R. K., Wilson, D. C., Kelsen, J. R., Cornall, R., Denson, L. A., Kugathasan, S., Knaus, U. G., Serra, E. G., Anderson, C. A., Duerr, R. H., McGovern, D. P. B., Cho, J., Powrie, Fiona, Li, V. S. W., Muise, A. M., Uhlig, H. H., Donnelly, P., Bell, J., Bentley, D., McVean, G., Ratcliffe, P., Taylor, J., Wilkie, A. O. M., Broxholme, J., Buck, D., Gregory, L., Gregory, J., Lunter, G., Tomlinson, I., Allan, C., Attar, M., Green, A., Humphray, S., Kingsbury, Z., Lamble, S., Lonie, L., Pagnamenta, A., Piazza, P., Polanco, G., Trebes, A., Copley, R., Fiddy, S., Grocock, R., Hatton, E., Holmes, C., Hughes, L., Humburg, P., Kanapin, A., Lise, S., Martin, H., Murray, L., McCarthy, D., Rimmer, A., Sahgal, N., Wright, B., Yau, C., Arancibia, Carolina, Bailey, Adam, Barnes, Ellie, Bird-Lieberman, Beth, Brain, Oliver, Braden, Barbara, Collier, Jane, East, James, Geremia, Alessandra, Howarth, Lucy, Keshav, Satish, Klenerman, Paul, Leedham, Simon, Palmer, Rebecca, Rodrigues, Astor, Simmons, Alison, Sullivan, Peter B, Travis, Simon P L, Uhlig, Holm H, Heuschkel, Rob, Zilbauer, Matthias, Auth, Marcus K. H., Shah, Neil, Kammermeier, Jochen, Croft, Nick, Barakat, Farah, Russell, Richard K., Wilson, David C., Henderson, Paul, Braegger, Christian P., Posovszky, Carsten, Fyderek, Krzysztof, Wedrychowicz, Andrzej, Zurek, Marlen, Strisciuglio, Caterina, Elawad, Mamoun, Lo, Bernice, Parkes, Miles, Satsangi, Jack, Anderson, Carl A., Jostins, L., Kennedy, N. A., Lamb, C. A., Ahmad, T., Edwards, C., Hart, A., Hawkey, C., Mansfield, J. C., Mowat, C., Newman, W. G., Satsangi, J., Simmons, A., Tremelling, M., Lee, J. C., Prescott, N. J., Lees, C. W., Barrett, J. C., UK IBD Genetics Consortium, COLORS in IBD, Oxford IBD cohort study investigators, WGS500 Consortium, INTERVAL Study, Schwerd, T., Bryant, R. V., Pandey, S., Capitani, M., Meran, L., Cazier, J. -B., Jung, J., Mondal, K., Parkes, M., Mathew, C. G., Fiedler, K., Mccarthy, D. J., Sullivan, P. B., Rodrigues, A., Travis, S. P. L., Moore, C., Sambrook, J., Ouwehand, W. H., Roberts, D. J., Danesh, J., Russell, R. K., Wilson, D. C., Kelsen, J. R., Cornall, R., Denson, L. A., Kugathasan, S., Knaus, U. G., Serra, E. G., Anderson, C. A., Duerr, R. H., Mcgovern, D. P. B., Cho, J., Powrie, Fiona, Li, V. S. W., Muise, A. M., Uhlig, H. H., Donnelly, P., Bell, J., Bentley, D., Mcvean, G., Ratcliffe, P., Taylor, J., Wilkie, A. O. M., Broxholme, J., Buck, D., Gregory, L., Gregory, J., Lunter, G., Tomlinson, I., Allan, C., Attar, M., Green, A., Humphray, S., Kingsbury, Z., Lamble, S., Lonie, L., Pagnamenta, A., Piazza, P., Polanco, G., Trebes, A., Copley, R., Fiddy, S., Grocock, R., Hatton, E., Holmes, C., Hughes, L., Humburg, P., Kanapin, A., Lise, S., Martin, H., Murray, L., Mccarthy, D., Rimmer, A., Sahgal, N., Wright, B., Yau, C., Arancibia, Carolina, Bailey, Adam, Barnes, Ellie, Bird-Lieberman, Beth, Brain, Oliver, Braden, Barbara, Collier, Jane, East, Jame, Geremia, Alessandra, Howarth, Lucy, Keshav, Satish, Klenerman, Paul, Leedham, Simon, Palmer, Rebecca, Rodrigues, Astor, Simmons, Alison, Sullivan, Peter B, Travis, Simon P L, Uhlig, Holm H, Heuschkel, Rob, Zilbauer, Matthia, Auth, Marcus K. H., Shah, Neil, Kammermeier, Jochen, Croft, Nick, Barakat, Farah, Russell, Richard K., Wilson, David C., Henderson, Paul, Braegger, Christian P., Posovszky, Carsten, Fyderek, Krzysztof, Wedrychowicz, Andrzej, Zurek, Marlen, Strisciuglio, Caterina, Elawad, Mamoun, Lo, Bernice, Parkes, Mile, Satsangi, Jack, Anderson, Carl A., Jostins, L., Kennedy, N. A., Lamb, C. A., Ahmad, T., Edwards, C., Hart, A., Hawkey, C., Mansfield, J. C., Mowat, C., Newman, W. G., Satsangi, J., Simmons, A., Tremelling, M., Lee, J. C., Prescott, N. J., Lees, C. W., Barrett, J. C., UK IBD Genetics, Consortium, COLORS in, Ibd, Oxford IBD cohort study, Investigator, Wgs500, Consortium, and Interval, Study
- Subjects
Male ,Genotype ,Colon ,Immunology ,Mutation, Missense ,Genetic Association Studie ,Polymorphism, Single Nucleotide ,Article ,Mice ,Animals ,Humans ,Immunology and Allergy ,Genetic Predisposition to Disease ,Child ,Genetic Association Studies ,Genes, Modifier ,Genome ,Animal ,Inflammatory Bowel Disease ,High-Throughput Nucleotide Sequencing ,Inflammatory Bowel Diseases ,digestive system diseases ,Host-Pathogen Interaction ,Mice, Inbred C57BL ,Child, Preschool ,Host-Pathogen Interactions ,NADPH Oxidase 1 ,Reactive Oxygen Species ,Reactive Oxygen Specie ,Human - Abstract
Genetic defects that affect intestinal epithelial barrier function can present with very early-onset inflammatory bowel disease (VEOIBD). Using whole-genome sequencing, a novel hemizygous defect in NOX1 encoding NAPDH oxidase 1 was identified in a patient with ulcerative colitis-like VEOIBD. Exome screening of 1,878 pediatric patients identified further seven male inflammatory bowel disease (IBD) patients with rare NOX1 mutations. Loss-of-function was validated in p.N122H and p.T497A, and to a lesser degree in p.Y470H, p.R287Q, p.I67M, p.Q293R as well as the previously described p.P330S, and the common NOX1 SNP p.D360N (rs34688635) variant. The missense mutation p.N122H abrogated reactive oxygen species (ROS) production in cell lines, ex vivo colonic explants, and patient-derived colonic organoid cultures. Within colonic crypts, NOX1 constitutively generates a high level of ROS in the crypt lumen. Analysis of 9,513 controls and 11,140 IBD patients of non-Jewish European ancestry did not reveal an association between p.D360N and IBD. Our data suggest that loss-of-function variants in NOX1 do not cause a Mendelian disorder of high penetrance but are a context-specific modifier. Our results implicate that variants in NOX1 change brush border ROS within colonic crypts at the interface between the epithelium and luminal microbes.
- Published
- 2018
54. Multicriteria decisions and portfolio analysis: land acquisition for biological and social objectives.
- Author
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Krainyk, Anastasia, Lyons, James E., Rice, Mindy B., Fowler, Kenneth A., Soulliere, Gregory J., Brasher, Michael G., Humburg, Dale D., and Coluccy, John M.
- Subjects
REAL property acquisition ,DECISION making ,BIRD conservation ,WILDLIFE refuges ,CONSTRAINED optimization ,MIGRATORY birds - Abstract
Resource allocation for land acquisition is a common multiobjective problem that involves complex trade‐offs. The National Wildlife Refuge System (NWRS) of the U.S. Fish and Wildlife Service currently uses the Targeted Resource Acquisition Comparison Tool (TRACT) to allocate funds from the Migratory Bird Conservation Fund (MBCF; established through the Migratory Bird Hunting and Conservation Act of 1934) for land acquisition based on cost–benefit analysis, regional priority rankings of candidate land parcels available for acquisition, and the overall biological contribution to duck population objectives. However, current policy encourages decision makers to consider societal and economic benefits of lands acquired, in addition to their biological benefits to waterfowl. These decisions about portfolio elements (i.e., individual land parcels) require an analysis of the difficult trade‐offs among multiple objectives. In the last decade the application of multicriteria decision analysis (MCDA) methods has been instrumental in aiding decision makers with complex multiobjective decisions. In this study, we present an alternative approach to developing land‐acquisition portfolios using MCDA and modern portfolio theory (MPT). We describe the development of a portfolio decision analysis tool using constrained optimization for land‐acquisition decisions by the NWRS. We outline the decision framework, describe development of the prototype tool in Microsoft Excel, and test the results of the tool using land parcels submitted as candidates for MBCF funding in 2019. Our results indicate that the constrained optimization outperformed the traditional TRACT method and ad hoc portfolios developed using current NWRS criteria. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
55. AltHapAlignR: improved accuracy of RNA-seq analyses through the use of alternative haplotypes
- Author
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Lee, W, Plant, K, Humburg, P, and Knight, J
- Subjects
Haplotypes ,Sequence Analysis, RNA ,Gene Expression Profiling ,Gene Expression ,Humans ,Leukocyte Common Antigens ,RNA ,Original Papers ,Alleles ,Software - Abstract
Motivation Reliance on mapping to a single reference haplotype currently limits accurate estimation of allele or haplotype-specific expression using RNA-sequencing, notably in highly polymorphic regions such as the major histocompatibility complex. Results We present AltHapAlignR, a method incorporating alternate reference haplotypes to generate gene- and haplotype-level estimates of transcript abundance for any genomic region where such information is available. We validate using simulated and experimental data to quantify input allelic ratios for major histocompatibility complex haplotypes, demonstrating significantly improved correlation with ground truth estimates of gene counts compared to standard single reference mapping. We apply AltHapAlignR to RNA-seq data from 462 individuals, showing how significant underestimation of expression of the majority of classical human leukocyte antigen genes using conventional mapping can be corrected using AltHapAlignR to allow more accurate quantification of gene expression for individual alleles and haplotypes. Availability and implementation Source code freely available at https://github.com/jknightlab/AltHapAlignR. Supplementary information Supplementary data are available at Bioinformatics online.
- Published
- 2018
56. Intracerebral hemorrhage in ICU: is it worth treating?
- Author
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Sivakumar, S, Taccone, F, Desai, K, Lazaridis, C, Skarzynski, M, Sekhon, M, Henderson, W, Griesdale, D, Chapple, L, Deane, A, Williams, L, Strickland, R, Lange, K, Heyland, D, Chapman, M, Rowland, M, Garry, P, Westbrook, J, Corkill, R, Antoniades, C, Pattinson, K, Fatania, G, Strong, A, Myers, R, Jermaine, C, Robertson, C, Rusin, C, Hofmeijer, J, Sondag, L, Tjepkema Cloostermans, M, Beishuizen, A, Bosch, F, van Putten, M, Carteron, L, Patet, C, Solari, D, Oddo, M, Ali, M, Dias, C, Almeida, R, Vaz Ferreira, A, Silva, J, Monteiro, E, Cerejo, A, Rocha, A, Elsayed, A, Abougabal, A, Beshey, B, Alzahaby, K, Pozzebon, S, Ortiz, A, Cristallini, S, Lheureux, O, Brasseur, A, Vincent, J, Creteur, J, Hravnak, M, Yousef, K, Chang, Y, Crago, E, Friedlander, R, Abdelmonem, S, Tahon, S, Helmy, T, Meligy, H, Puig, F, Dunn Siegrist, I, Pugin, J, Gupta, S, Govil, D, Srinivasan, S, Patel, S, N, J, Gupta, A, Tomar, D, Shafi, M, Harne, R, Arora, D, Talwar, N, Mazumdar, S, Papakrivou, E, Makris, D, Manoulakas, E, Tsolaki, B, Karadodas, B, Zakynthinos, E, Garcia, I, Martin, A, Encinares, V, Ibañez, M, Montero, J, Labrador, G, Cangueiro, T, Poulose, V, Koh, J, Kam, J, Yeter, H, Kara, A, Aktepe, O, Topeli, A, Tsolakoglou, I, Intas, G, Stergiannis, P, Kolaros, A, Chalari, E, Athanasiadou, E, Martika, A, Fildisis, G, Faivre, V, Mengelle, C, Favier, B, Payen, D, Poppe, A, Winkler, M, Mudersbach, E, Schreiber, J, Wruck, M, Schwedhelm, E, Kluge, S, Zöllner, C, Tavladaki, T, Spanaki, A, Dimitriou, H, Kondili, E, Choulaki, C, Meleti, E, Kafetzopoulos, D, Georgopoulos, D, Briassoulis, G, la Torre, A, de la Torre Prados, M, Tsvetanova Spasova, T, Nuevo Ortega, P, Rueda Molina, C, Fernández Porcel, A, Camara Sola, E, Salido Díaz, L, García Alcántara, A, Meleti, D, Suberviola, B, Riera, J, Rellan, L, Sanchez, M, Robles, J, Lopez, E, Vicente, R, Miñambres, E, Santibañez, M, Le Guen, M, Moore, J, Mason, N, Windpassinger, M, Plattner, O, Mascha, E, Sessler, D, Research, O, Melia, U, Fontanet, J, van den Berg, J, Struys, M, Vereecke, H, Jensen, E, Rood, P, van de Schoor, F, van Tertholen, K, Pickkers, P, van den Boogaard, M, Beardow, Z, Redhead, H, Paramasivam, K, Numan, T, Kamper, A, Peelen, L, Zeman, P, Slooter, A, van Ewijk, C, Jacobs, G, Girbes, A, Myatra, S, Harish, M, Prabu, N, Siddiqui, S, Kulkarni, A, Divatia, J, Murbach, L, Leite, M, Osaku, E, Costa, C, Pelenz, M, Neitzke, N, Moraes, M, Jaskowiak, J, Silva, M, Zaponi, R, Abentroth, L, Ogasawara, S, Jorge, A, Duarte, P, Hernández Sánchez, N, Sánchez Hurtado, L, García Guillen, F, Ñamendys Silva, S, Maghsoudi, B, Emami, M, Khosravi, M, Zand, F, Tabatabaie, H, Masjedi, M, Sabetiyan, G, Mokri, A, Troubleyn, J, Diltoer, M, Jacobs, R, Nguyen, D, De Waele, E, De Regt, J, Honoré, P, Van Gorp, V, Spapen, H, Contreras, R, Toapanta, N, Moreno, G, Sabater, J, Torrado, H, Gonzalez, M, Marin, M, Farigola, E, Gonzalez, A, Fernandez, J, Vera, A, Gisbert, X, Juliá, C, Uya, J, Corral, L, Elias Jones, I, Gemmell, L, Mackay, A, Randall, D, Adwaney, A, Blunden, M, Prowle, J, Kirwan, C, Thomas, N, Owen, H, Darwin, L, Conway, D, Atkinson, D, Sharman, M, Barbanti, C, Amour, J, Gaudard, P, Rozec, B, Mauriat, P, M'Rini, M, Leger, P, Cambonie, G, Liet, J, Girard, C, Laroche, S, Damas, P, Assaf, Z, Loron, G, Lecourt, L, Pouard, P, Kim, S, Na, S, Kim, J, Oh, S, Jung, C, Yoo, S, Min, S, Chung, E, Lee, H, Lee, N, Lee, K, Suh, K, Ryu, H, Marshall, D, Goodson, R, Salciccioli, J, Shalhoub, J, Potter, E, Kirk Bayley, J, Karanjia, N, Forni, L, Creagh Brown, B, Bossy, M, Nyman, M, Tailor, A, D'Antini, D, Spadaro, S, Valentino, F, Sollitto, F, Cinnella, G, Mirabella, L, Calvo, F, Bejarano, N, Padilla, D, Baladron, V, Villajero, P, Villazala, R, Redondo, J, Yuste, A, Liu, J, Shen, F, Teboul, J, Anguel, N, Beurton, A, Bezaz, N, Richard, C, Monnet, X, Fossali, T, Colombo, R, Ottolina, D, Rossetti, M, Mazzucco, C, Marchi, A, Porta, A, Catena, E, Tollisen, K, Andersen, G, Heyerdahl, F, Jacobsen, D, de Waard, M, van IJzendoorn, M, Buter, H, Kingma, W, Navis, G, Boerma, E, Rulisek, J, Balik, M, Zacharov, S, Kim, H, Jeon, S, Namgung, H, Lee, E, Cho, Y, Lee, Y, Huang, A, Cioccari, L, Luethi, N, Mårtensson, J, Bellomo, R, Forsberg, M, Edman, G, Höjer, J, Forsberg, S, Freile, M, Hidalgo, F, Molina, J, Lecumberri, R, Rosselló, A, Travieso, P, Leon, G, Sanchez, J, Frias, L, Rosello, D, Verdejo, J, Serrano, J, Winterwerp, D, van Galen, T, Vazin, A, Karimzade, I, Zand, A, Ozen, E, Ekemen, S, Akcan, A, Sen, E, Yelken, B, Kureshi, N, Fenerty, L, Thibault Halman, G, Erdogan, M, Walling, S, Green, R, Clarke, D, Briassoulis, P, Kalimeris, K, Ntzouvani, A, Nomikos, T, Papaparaskeva, K, Politi, E, Kostopanagiotou, G, Crewdson, K, Rehn, M, Weaver, A, Brohi, K, Lockey, D, Wright, S, Thomas, K, Baker, C, Mansfield, L, Stafford, V, Wade, C, Watson, G, Bryant, A, Chadwick, T, Shen, J, Wilkinson, J, Furneval, J, Henderson, A, Hugill, K, Howard, P, Roy, A, Bonner, S, Baudouin, S, Ramírez, C, Escalada, S, Viera, M, Santana, M, Balcázar, L, Monroy, N, Campelo, F, Vázquez, C, Santana, P, Santana, S, Quintard, H, Bouzat, P, Wollersheim, T, Malleike, J, Haas, K, Carbon, N, Schneider, J, Birchmeier, C, Fielitz, J, Spuler, S, Weber Carstens, S, Enseñat, L, Pérez Madrigal, A, Saludes, P, Proença, L, Gruartmoner, G, Espinal, C, Mesquida, J, Huber, W, Eckmann, M, Elkmann, F, Gruber, A, Lahmer, T, Mayr, U, Herner, A, Schellnegger, R, Schmid, R, Ayoub, W, Samy, W, Esmat, A, Battah, A, Mukhtar, S, Mongkolpun, W, Cortés, D, Cordeiro, C, Funcke, S, Groesdonk, H, Saugel, B, Wagenpfeil, G, Wagenpfeil, S, Reuter, D, Fernandez, M, Fernandez, R, Magret, M, González Castro, A, Bouza, M, García, C, Balerdi, B, Mas, A, Arauzo, V, Añón, J, Ruiz, F, Ferreres, J, Tomás, R, Alabert, M, Tizón, A, Altaba, S, Llamas, N, Goligher, E, Fan, E, Herridge, M, Vorona, S, Sklar, M, Dres, M, Rittayamai, N, Lanys, A, Urrea, C, Tomlinson, G, Reid, W, Rubenfeld, G, Kavanagh, B, Brochard, L, Ferguson, N, Neto, A, de Abreu, M, Pelosi, P, Schultz, M, Guérin, C, Papazian, L, Reignier, J, Ayzac, L, Loundou, A, Forel, J, Rolland Debord, C, Bureau, C, Poitou, T, Clavel, M, Perbet, S, Terzi, N, Kouatchet, A, Similowski, T, Demoule, A, Hunfeld, N, Trogrlic, Z, Ladage, S, Osse, R, Koch, B, Rietdijk, W, Devlin, J, van der Jagt, M, Picetti, E, Ceccarelli, P, Mensi, F, Malchiodi, L, Risolo, S, Rossi, I, Antonini, M, Servadei, F, Caspani, M, Roquilly, A, Lasocki, S, Seguin, P, Geeraerts, T, Perrigault, P, Dahyot Fizelier, C, Paugam Burtz, C, Cook, F, Cinotti, R, Dit Latte, D, Mahe, P, Fortuit, C, Feuillet, F, Asehnoune, K, Marzorati, C, Spina, S, Scaravilli, V, Vargiolu, A, Riva, M, Barbadillo, S, de Molina, F, Álvarez Lerma, F, Rodríguez, A, Zakharkina, T, Martin Loeches, I, Matamoros, S, Povoa, P, Torres, A, Kastelijn, J, Hofstra, J, de Jong, M, Sterk, P, Artigas, A, Bos, L, Moreau, A, Salluh, J, Rodriguez, A, Nseir, S, de Jong, E, van Oers, J, Nijsten, M, de Lange, D, Bonvicini, D, Labate, D, Benacchio, L, Olivieri, A, Pizzirani, E, Lopez Delgado, J, Gonzalez Romero, M, Fuentes Mila, V, Berbel Franco, D, Romera Peregrina, I, Martinez Pascual, A, Perez Sanchez, J, Abellan Lencina, R, Ávila Espinoza, R, Moreno Gonzalez, G, Sbraga, F, Griffiths, S, Grocott, M, Doyle, J, Wilkerson, P, Soon, Y, Huddart, S, Dickinson, M, Riga, A, Zuleika, A, Miyamoto, K, Kawazoe, Y, Morimoto, T, Yamamoto, T, Fuke, A, Hashimoto, A, Koami, H, Beppu, S, Katayama, Y, Ito, M, Ohta, Y, Yamamura, H, Rygård, S, Holst, L, Wetterslev, J, Johansson, P, Perner, A, Soliman, I, van Dijk, D, van Delden, J, Cremer, O, Mcwilliams, D, Snelson, C, Neves, A, Loudet, C, Busico, M, Vazquez, D, Villalba, D, Veronesi, M, Lischinsky, A, López, F, Mori, L, Plotnikow, G, Díaz, A, Giannasi, S, Hernandez, R, Krzisnik, L, Cecotti, C, Viola, L, Lopez, R, Sottile, J, Benavent, G, Estenssoro, E, Chen, C, Lai, C, Cheng, K, Chou, W, Chan, K, Roeker, L, Horkan, C, Gibbons, F, Christopher, K, Weijs, P, Mogensen, K, Rawn, J, Robinson, M, Tang, Z, Qiu, C, Ouyang, B, Cai, C, Guan, X, Regueira, T, Cea, L, Carlos, S, Elisa, B, Puebla, C, Vargas, A, Poulsen, M, Thomsen, L, Kjærgaard, S, Rees, S, Karbing, D, Frank, S, Müller, M, Skrypnikov, V, Pickerodt, P, Falk, R, Mahlau, A, Lee, A, Inglis, R, Morgan, R, Barker, G, Kamata, K, Abe, T, Saitoh, D, Tokuda, Y, Butler, M, Hwa, H, Gil, L, Vaquero, R, Rodriguez Ruiz, E, Lago, A, Allut, J, Gestal, A, Thomas Rüddel, D, Schwarzkopf, D, Fleischmann, C, Reinhart, K, Suwanpasu, S, Sattayasomboon, Y, Filho, N, Oliveira, J, Ballalai, C, De Lucia, C, Araponga, G, Veiga, L, Silva, C, Garrido, M, Ramos, B, Ricaldi, E, Gomes, S, Wright, C, Docking, R, Doherty, P, Black, E, Stenhouse, P, Plummer, M, Finnis, M, Phillips, L, Kar, P, Bihari, S, Biradar, V, Moodie, S, Horowitz, M, Shaw, J, Yatabe, T, Inoue, S, Sakaguchi, M, Egi, M, Abdelhamid, Y, Hokka, M, Mizobuchi, S, Giersch, E, Summers, M, Hatzinikolas, S, Heller, S, Jones, K, Schweizer, R, Jacquet Lagreze, M, Portran, P, Junot, S, Allaouchiche, B, Fellahi, J, Guerci, P, Ergin, B, Kapucu, A, Ince, 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Laisne, L, Rabbat, A, Lebert, C, Perez, P, Chaize, M, Renault, A, Meert, A, Hamidfar, R, Jourdain, M, Darmon, M, Schlemmer, B, Chevret, S, Lemiale, V, Azoulay, E, Benoit, D, Martins Branco, D, Sousa, M, Marum, S, Bouw, M, Galstyan, G, Makarova, P, Parovichnikova, E, Kuzmina, L, Troitskaya, V, Drize, N, Gemdzhian, E, Savchenko, V, Chao, H, Kılıc, E, Demiriz, B, Uygur, M, Sürücü, M, Cınar, K, Yıldırım, A, Kiss, K, Köves, B, Csernus, V, Molnár, Z, Ntantana, A, Matamis, D, Savvidou, S, Giannakou, M, Gouva, M, Nakos, G, Koulouras, V, Gaffney, S, Judge, C, Drew, T, Misran, H, Munshi, R, Mcgovern, L, Coyle, M, Dunne, L, Deasy, E, Lavin, P, Fahy, A, Darcy, D, Donnelly, M, Ismail, N, Hall, T, Wykes, K, Jack, J, Ngu, W, Morgan, P, Ruiz Ramos, J, Ramirez, P, Gordon, M, Villarreal, E, Frasquet, J, Poveda Andrés, J, Castellanos, A, Ijssennagger, C, Ten Hoorn, S, van Wijk, A, van den Broek, J, Tuinman, P, Elmenshawy, A, Hammond, B, Gibbon, G, Belcham, T, Burton, K, Taniguchi, L, Ramos, F, Momma, A, Martins Filho, A, Bartocci, J, Lopes, M, Sad, M, Rodrigues, C, Pires, E, Barreto, J, Duarte, S, Taba, S, Miglioranza, D, Gund, D, Lordani, C, Capuzzo, M, Corte, F, Terranova, S, Scaramuzzo, G, Fogagnolo, A, Bertacchini, S, Bellonzi, A, Ragazzi, R, Cruz, C, Nunes, A, Pereira, F, Aragão, I, Cardoso, A, Santos, C, Malheiro, M, Castro, H, Cardoso, T, Paratz, J, Kenardy, J, Comans, T, Coyer, F, Thomas, P, Boots, R, Pereira, N, Vilas Boas, A, Gomes, E, Torres, J, Carvalho, D, Molinos, E, Vales, C, Araújo, R, Karnatovskaia, L, Philbrick, K, Ognjen, G, Clark, M, Montero, R, Varas, J, Sánchez Elvira, L, Delgado, C, Díaz, P, Ruiz, B, Guerrero, A, Galache, J, Jiménez, R, Rebollo, S, Alejandro, O, Fernández, A, Moreno, S, Herrera, L, Ojados, A, Galindo, M, Murcia, J, Contreras, M, Sánchez Argente, S, Bonilla, Y, Rodríguez, M, Allegue, J, Cakin, Ö, Parlak, H, Kirca, H, Mutlu, F, Aydınlı, B, Cengiz, M, Ramazanoglu, A, Jung, E, Domenech, J, Montalvo, A, Chornet, T, Martinez, P, Ribas, M, Costa, R, Ortega, A, Forbes, C, Prescott, H, Lal, A, Khan, F, Dela Pena, E, Dizon, J, Wong, C, Garach, M, Romero, O, Puerta, R, Diaz, F, Bailon, A, Pinel, A, Maldonado, L, Kalaiselvan, M, Kumar, R, Renuka, M, De Rosa, S, Ferrari, F, Checcacci, S, Rigobello, A, Joannidis, M, Politi, F, Pellizzari, A, Bonato, R, Fernandez Carmona, A, Macias Guarasa, I, Gutierrez Rodriguez, R, Martinez Lopez, P, Diaz Castellanos, M, Arias Diaz, M, Aguilar Alonso, E, Nikandish, R, Artemenko, V, Budnyuk, A, Bassi, G, Senussi, T, Idone, F, Xiol, E, Travierso, C, Chiurazzi, C, Motos, A, Amaro, R, Hua, Y, Fernández Barat, L, Ranzani, O, Bobi, Q, Rigol, M, Youn, A, Hwang, J, Ossorio, M, Figueira, H, Oliveira, R, Mota, A, Kamp, O, Cruciger, O, Aach, M, Kaczmarek, C, Waydhas, C, Schildhauer, T, Hamsen, U, Camprubí Rimblas, M, Chimenti, L, Guillamat Prats, R, Lebouvier, T, Bringué, J, Tijero, J, Gómez, M, Blanch, L, Tagliabue, G, Ji, M, Jagers, J, Easton, P, Hong, J, Shin, M, Park, M, Pomprapa, A, Hofferberth, M, Russ, M, Braun, W, Walter, M, Francis, R, Lachmann, B, Leonhardt, S, Landaverde López, A, Canedo Castillo, N, Esquivel Chávez, A, Arvizu Tachiquín, P, Baltazar Torres, J, Cardoso, V, Krystopchuk, A, Castro, S, Melão, L, Firmino, S, Marreiros, A, Almaziad, S, Kubbara, A, Barnett, W, Nakity, R, Alamoudi, W, Altook, R, Tarazi, T, Fida, M, Safi, F, Assaly, R, Santini, A, Milesi, M, Maraffi, T, Pugni, P, Cavenago, M, Gattinoni, L, Protti, A, Perchiazzi, G, Borges, J, Bayat, S, Porra, L, Broche, L, Hedenstierna, G, Larsson, A, Roneus, A, Segelsjö, M, Vestito, M, Gremo, E, Nyberg, A, Castegren, M, Pikwer, A, Yoshida, T, Engelberts, D, Otulakowski, G, Katira, B, Post, M, Amato, M, Koch, N, Hoellthaler, J, Mair, S, Phillip, V, Beitz, A, Baladrón, V, Villarejo, P, Steenstra, R, Banierink, H, Hof, J, Hoekstra, M, Sterz, F, Horvatits, K, Herkner, H, Kott, M, Zitta, K, Brandt, B, Schildhauer, C, Elke, G, Hummitzsch, L, Albrecht, M, González, L, Alonso, D, Sánchez, R, Lucas, J, Ferlitsch, A, Fauler, G, Trauner, M, Pischke, S, Fischer, L, Thaiss, F, Koch, M, Bangert, K, Lohse, A, Nashan, B, Sterneck, M, Faenza, S, Siniscalchi, A, Pierucci, E, Mancini, E, Ricci, D, Gemelli, C, Cuoghi, A, Magnani, S, Atti, M, Sotos, F, Cánovas, J, López, A, Burruezo, A, Torres, D, Herrera Gutierrez, M, Barrueco Francioni, J, Arias Verdú, D, Lozano Saez, R, Quesada Garcia, G, Seller Pérez, G, Figueiredo, A, Anzola, Y, Pereira, R, Bento, L, Lai, M, Deiana, M, Seller Perez, G, Vardas, K, Ilia, S, Sertedaki, A, Charmadari, E, Stratakis, C, Briassouli, E, Goukos, D, Psarra, K, Botoula, E, Tsagarakis, S, Mageira, E, Routsi, C, Nanas, S, Campello, E, Radu, C, Su, H, Lam, Y, Willis, K, Pullar, V, Hubner, R, Tsang, J, de Guadiana Romualdo, L, Rebollo Acebes, S, Esteban Torrella, P, Jiménez Sánchez, R, Jiménez Santos, E, Ortín Freire, A, Hernando Holgado, A, Albaladejo Otón, M, Coelho, L, Rabello, L, Póvoa, P, Varis, E, Poukkanen, M, Jacob, S, Takala, J, Wilkman, E, Lundberg, O, Bergenzaun, L, Rydén, J, Rosenqvist, M, Melander, O, Chew, M, Kishihara, Y, Yasuda, H, Jimenez, R, Torrella, P, Fernandez, A, Sanchez, S, Ortin, A, Prats, R, Aguilera, E, Marti, D, Fernandez, L, Ferrer, M, Lanziotti, V, Pulcheri, L, Ribeiro, M, Barbosa, A, E. Silva, J, Soares, M, Marqués, M, Moreno, A, Pizarraya, A, Smani, Y, Connell, M, Zhang, L, Parker, R, Banerjee, I, Clermont, G, Norberg, E, Oras, J, Cuisinier, A, Maufrais, C, Payen, J, Nottin, S, Walther, G, Arib, S, Bilotta, F, Badenes, R, Rubulotta, F, Mirek, S, Monfort, B, Stazi, E, Roig, A, Magnoni, S, Marando, M, Pifferi, S, Conte, V, Ortolano, F, Carbonara, M, Bertani, G, Scola, E, Cadioli, M, Triulzi, F, Colombo, A, Stocchetti, N, Rotzel, H, Lázaro, A, Prada, D, Guimillo, M, Piqueras, C, Guia, J, Simon, M, Arizmendi, A, Carratalá, A, El Maraghi, S, Yehia, A, Bakry, M, Shoman, A, Backes, F, Bianchin, M, Vieira, S, de Souza, A, Backes, A, Klein, C, Arunkumar, A, Lozano, A, Gallaher, C, Cattlin, S, Gordon, S, Picard, J, Fontana, V, Bond, O, Nobile, L, Mrozek, S, Delamarre, L, Capilla, F, Al Saati, T, Fourcade, O, Dominguez Berrot, A, Gonzalez Vaquero, M, Vallejo Pascual, M, Gupta, D, Ivory, B, Chopra, M, Mccarthy, J, Felderhof, C, Macneil, C, Maggiorini, M, Duska, F, Fumis, R, Junior, J, Amarante, G, Skorko, A, Sanders, S, Aron, J, Kroll, R, Redfearn, C, Krishnan, P, Khalil, J, Kongpolprom, N, Gulia, V, Lourenço, E, Duro, C, Baptista, G, Alves, A, Arminda, B, Rodrigues, M, Hayward, J, Baldwin, F, Gray, R, Katinakis, P, Stijf, M, Ten Kleij, M, Jansen Frederiks, M, Broek, R, de Bruijne, M, Spronk, P, Sinha, K, Luney, M, Palmer, K, Keating, L, Abu Habsa, M, Bahl, R, Baskaralingam, N, Ahmad, A, Kanapeckaite, L, Bhatti, P, Glace, S, Jeyabraba, S, Lewis, H, Kostopoulos, A, Raja, M, West, A, Ely, A, Turkoglu, L, Zolfaghari, P, Baptista, J, Marques, M, Martins, P, Pimentel, J, Su, Y, Villacres, S, Stone, M, Parsikia, A, Medar, S, O'Dea, K, Porter, J, Tirlapur, N, Jonathan, J, Singh, S, Takata, M, Mcwhirter, E, Lyon, R, Hariz, M, Azmi, E, Alkhan, J, Movsisyan, V, Petrikov, S, Marutyan, Z, Aliev, I, Evdokimov, A, Antonucci, E, Merz, T, Hartmann, C, Calzia, E, Radermacher, P, Nußbaum, B, Huber Lang, M, Gröger, M, Svoren Jabalera, E, Davenport, E, Humburg, P, Knight, J, Hinds, C, Jun, I, Kim, W, Besch, G, Perrotti, A, Puyraveau, M, Baltres, M, Samain, E, Chocron, S, Pili Floury, S, Plata Menchaca, E, Sabater Riera, J, Estruch, M, Boza, E, Toscana Fernández, J, Bruguera Pellicer, E, Ordoñez Llanos, J, Pérez Fernández, X, Cavaleiro, P, Tralhão, A, Arrigo, M, Lopes, J, Lebrun, M, Cholley, B, Perezvela, J, Marinmateos, H, Rivera, J, Llorente, M, De Marcos, B, Fernandez, F, Laborda, C, Zamora, D, Delgado, J, Imperiali, C, Dastis, M, Górka, J, Górka, K, Iwaniec, T, Frołow, M, Polok, K, Fronczek, J, Kózka, M, Musiał, J, Szczeklik, W, Sileli, M, Moursia, C, Maleoglou, H, Leleki, K, Uz, Z, Ince, Y, Papatella, R, Bulent, E, De Mol, B, Vicka, V, Gineityte, D, Ringaitiene, D, Norkiene, I, Sipylaite, J, Möller, C, Thomas Rueddel, D, Vlasakov, V, Rochwerg, B, Theurer, P, Al Sibai, J, Camblor, P, Fernandez, P, Gala, J, Guisasola, J, Tamura, T, Miyajima, I, Yamashita, K, Yokoyama, M, Dalampini, E, Nastou, M, Baddour, A, Ignatiadis, A, Asteri, T, Hathorn, K, Purtle, S, Viana, M, Tonietto, T, Gross, L, Costa, V, Tavares, A, Lisboa, B, Moraes, R, Viana, L, Azevedo, M, Ceniccola, G, Pequeno, R, Holanda, T, Mendonça, V, Araújo, W, Carvalho, L, Segaran, E, Vickers, L, Brinchmann, K, Wignall, I, De Brito Ashurst, I, Del Olmo, R, Vaquerizo, C, Carreño, R, Gálvez, V, Kaminsky, G, Nieto, B, Fuentes, M, De la Torre, M, Torres, E, Alonso, A, Velayos, C, Saldaña, T, Escribá, A, Grip, J, Kölegård, R, Sundblad, P, Rooyackers, O, Naser, B, Jaziri, F, Jazia, A, Barghouth, M, Hentati, O, Skouri, W, El Euch, M, Mahfoudhi, M, Turki, S, Abdelghni, K, Abdallah, B, Maha, B, Lorente, M, Włudarczyk, A, Hałek, A, Bargouth, M, Bennasr, M, Abdelghani, K, Abdallah, T, Geenen, I, Parienti, J, Shum, H, King, H, Yan, W, Londoño, J, Cardenas, C, Pedrosa, M, Gubianas, C, Bertolin, C, Batllori, N, Sirvent, J, Mukhopadhyay, A, Chan, H, Kowitlawakul, Y, Remani, D, Leong, C, Henry, C, Puthucheary, Z, Mendsaikhan, N, Begzjav, T, Lundeg, G, Dünser, M, Welsh, S, Guerra, E, Zerpa, M, Zechner, F, Berdaguer, F, Risso Vazquez, A, Masevicius, F, Greaney, D, Magee, A, Fitzpatrick, G, Lugo Cob, R, Tejeda Huezo, B, Cano Oviedo, A, Aydogan, M, Togal, T, Taha, A, Chai, H, Kam, C, Razali, S, Sivasamy, V, Kuan, L, Morales, M, Pires, T, and Azevedo, L
- Subjects
intracerebral haemorrhage in intensive care - Published
- 2016
57. A Humbug Approach to Economics. Division of Labor-Specialization. Teacher's Guide [and] Student Package, Capsules No. 1, 2, and 3.
- Author
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Project Consumer Operations Survival Training (COST), Easton, KS. and Humburg, Judy
- Abstract
Intended for above average students in grades 4-6, this unit contains student materials and teacher's guide for three sequential lessons on the economic concepts of specialization and division of labor. The units are presented in story form accompanied by cartoon illustrations. In section one students distinguish between goods and services and examine the concept of bartering. Students fill out worksheets on goods and services they used during the week, interview parents and grandparents about their perceptions of luxuries, and make a glossary of relevant terms. Section two examines advertising and the theory of supply and demand. Students fill out charts on sources of advertising, do a class survey of toothpaste brands used, and chart resource needs, probable consumers, and possible jobs created by certain products or services. In section three students analyze the advantages of specialization and identify levels of jobs according to education and training needed. Activities include designing an assembly line. Each section contains a self-check capsule and a pre- and posttest. The teacher's guide lists objectives and materials needed and provides reproducible worksheets and tests with keys. (KC)
- Published
- 1979
58. Occupational Sex-Role Stereotyping. Effects of a Ninth-Grade Experience-Based Career Education Program on Occupational Sex-Role Stereotyping.
- Author
-
Humburg, Renae Bygel
- Abstract
A study was conducted to determine the effects of a ninth-grade experience-based career education (EBCE) program upon occupational sex role stereotyping. Twenty-four volunteers were assigned to the EBCE group and twenty-four assigned to the control group. The career education group met four class periods per week and one full day per week for community resource site exploration. Students explored both traditional and nontraditional occupations for men and women in the community. Positive effect was defined in terms of lower absolute values assigned to occupational sex-role stereotyping scores on an occupational role identification inventory. Findings indicated a significant difference between the EBCE group and the control group on occupational sex role stereotyping measures of the occupational role identification inventory. The EBCE group was significantly less sex stereotyped in their view of the occupational world than was the control group. (LRA)
- Published
- 1980
59. Teaching Adult Vocational Education Learners. Annotated and Selected Bibliography. Final Report.
- Author
-
University of Northern Colorado, Greeley. Coll. of Education., Warner, Larry S., and Humburg, Renae
- Abstract
This selected annotated bibliography contains eighty-three entries (includes books, reports, guides, papers, and articles) relevant to teaching adult vocational education learners. The citations are organized alphabetically by author and each one includes some or all of the following: source, title, sponsoring agency, publisher, city, state, date, pages reviewed, and an annotation. Some representative titles include the following:"Meeting the Needs of Working Class Women in Post Secondary Education"; "Voluntarism: The Real and Emerging Power"; "Continuing Education in Canadian Universities"; "Community Education and Its Major Components"; "Teaching Adults"; "Career Education: Community Resource Center"; "Lifelong Learning"; "Finding Community: A Guide to Community Research and Action"; "The Physiology of Aging: How It Affects Learning"; "Goal Analysis"; "Recurrent Education"; "Tested Techniques for Teachers of Adults"; "Teacher's Role in Life-Centering the Curriculum"; "Guide to Adult Education Counseling"; and "Passages: Predictable Crises of Adult Life." (EM)
- Published
- 1977
60. Microcomputers in Business Minicourses--Maximum Results.
- Author
-
Humburg, Renae Bygel and Cockley, Durla M.
- Abstract
Describes the business minicourse program and its use of microcomputers at Burns High School in Wyoming. Includes a planning chart as well as information on program implementation, results, and teacher responsibility. (JOW)
- Published
- 1983
61. ESICM LIVES 2016: part two
- Author
-
Sivakumar, S., Taccone, F. S., Desai, K. A., Lazaridis, C., Skarzynski, M., Sekhon, M., Henderson, W., Griesdale, D., Chapple, L., Deane, A., Williams, L., Strickland, R., Lange, K., Heyland, D., Chapman, M., Rowland, M. J., Garry, P., Westbrook, J., Corkill, R., Antoniades, C. A., Pattinson, K. T., Fatania, G., Strong, A. J., Myers, R. B., Jermaine, C. M., Robertson, C. S., Rusin, C. G., Hofmeijer, J., Sondag, L., Tjepkema-Cloostermans, M. C., Beishuizen, A., Bosch, F. H., van Putten, M. J. A. M., Carteron, L., Patet, C., Solari, D., Oddo, M., Ali, M. A., Dias, C., Almeida, R., Vaz-Ferreira, A., Silva, J., Monteiro, E., Cerejo, A., Rocha, A. P., Elsayed, A. A., Abougabal, A. M., Beshey, B. N., Alzahaby, K. M., Pozzebon, S., Ortiz, A. Blandino, Cristallini, S., Lheureux, O., Brasseur, A., Vincent, J. L., Creteur, J., Hravnak, M., Yousef, K., Chang, Y., Crago, E., Friedlander, R. M., Abdelmonem, S. A., Tahon, S. A., Helmy, T. A., Meligy, H. S., Puig, F., Dunn-Siegrist, I., Pugin, J., Gupta, S., Govil, D., Srinivasan, S., Patel, S. J., N, J. K., Gupta, A., Tomar, D. S., Shafi, M., Harne, R., Arora, D. P., Talwar, N., Mazumdar, S., Papakrivou, E. E., Makris, D., Manoulakas, E., Tsolaki, B., Karadodas, B., Zakynthinos, E., Garcia, I. Palacios, Martin, A. Diaz, Encinares, V. Sanchez, Ibañez, M. Pachón, Montero, J. Garnacho, Labrador, G., Cangueiro, T. Cebrero, Poulose, V., Koh, J., Kam, J. W., Yeter, H., Kara, A., Aktepe, O., Topeli, A., Tsolakoglou, I., Intas, G., Stergiannis, P., Kolaros, A. A., Chalari, E., Athanasiadou, E., Martika, A., Fildisis, G., Faivre, V., Mengelle, C., Favier, B., Payen, D., Poppe, A., Winkler, M. S., Mudersbach, E., Schreiber, J., Wruck, M. L., Schwedhelm, E., Kluge, S., Zöllner, C., Tavladaki, T., Spanaki, A. M., Dimitriou, H., Kondili, E., Choulaki, C., Meleti, E., Kafetzopoulos, D., Georgopoulos, D., Briassoulis, G., la Torre, A. García-de, de la Torre-Prados, M. V., Tsvetanova-Spasova, T., Nuevo-Ortega, P., Rueda-Molina, C., Fernández-Porcel, A., Camara-Sola, E., Salido-Díaz, L., García-Alcántara, A., Meleti, D. E., Suberviola, B., Riera, J., Rellan, L., Sanchez, M., Robles, J. C., Lopez, E., Vicente, R., Miñambres, E., Santibañez, M., Le Guen, M., Moore, J., Mason, N., Windpassinger, M., Plattner, O., Mascha, E., Sessler, D. I., Research, Outcomes, Melia, U., Fontanet, J., van den Berg, J. P., Struys, M. M. R. F., Vereecke, H. E. M., Jensen, E. W., Rood, P. J. T., van de Schoor, F., van Tertholen, K., Pickkers, P., van den Boogaard, M., Beardow, Z. J., Redhead, H., Paramasivam, K., Numan, T., Kamper, A. M., Rood, P., Peelen, L. M., Zeman, P. M., Slooter, A. J., van Ewijk, C. E., Jacobs, G. E., Girbes, A. R. J., Myatra, S. N., Harish, M. M., Prabu, N. R., Siddiqui, S., Kulkarni, A. P., Divatia, J. V., Murbach, L. D., Leite, M. A., Osaku, E. F., Costa, C. R. L. M., Pelenz, M., Neitzke, N. M., Moraes, M. M., Jaskowiak, J. L., Silva, M. M. M., Zaponi, R. S., Abentroth, L. R. L., Ogasawara, S. M., Jorge, A. C., Duarte, P. A. D., Hernández-Sánchez, N., Sánchez-Hurtado, L. A., García-Guillen, F. J., Ñamendys-Silva, S. A., Maghsoudi, B., Emami, M., Khosravi, M. B., Zand, F., Tabatabaie, H. R., Masjedi, M., Sabetiyan, G., Mokri, A., Troubleyn, J., Diltoer, M., Jacobs, R., Nguyen, D. N., De Waele, E., De Regt, J., Honoré, P. M., Van Gorp, V., Spapen, H. D., Contreras, R. S., Toapanta, N. D., Moreno, G., Sabater, J., Torrado, H., Gonzalez, M., Marin, M., Farigola, E., Gonzalez, A., Fernandez, J., Vera, A., Gisbert, X., Juliá, C., Uya, J., Corral, L., Elias-Jones, I., Gemmell, L., MacKay, A., Randall, D., Adwaney, A., Blunden, M., Prowle, J. R., Kirwan, C. J., Thomas, N., Martin, A., Owen, H., Darwin, L., Conway, D., Atkinson, D., Sharman, M., Barbanti, C., Amour, J., Gaudard, P., Rozec, B., Mauriat, P., M’rini, M., Leger, P. L., Cambonie, G., Liet, J. 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P., Hamidfar, R., Jourdain, M., Darmon, M., Schlemmer, B., Chevret, S., Lemiale, V., Azoulay, E., Benoit, D., Martins-Branco, D., Sousa, M., Marum, S., Bouw, M. J., Galstyan, G., Makarova, P., Parovichnikova, E., Kuzmina, L., Troitskaya, V., Drize, N., Gemdzhian, E., Savchenko, V., Chao, H. C., Kılıc, E., Demiriz, B., Uygur, M. L., Sürücü, M., Cınar, K., Yıldırım, A. E., Kiss, K., Köves, B., Csernus, V., Molnár, Z., Ntantana, A., Matamis, D., Savvidou, S., Giannakou, M., Gouva, M., Nakos, G., Koulouras, V., Gaffney, S., Docking, R., Judge, C., Drew, T., Misran, H., Munshi, R., McGovern, L., Coyle, M., Dunne, L., Deasy, E., Lavin, P., Fahy, A., Darcy, D. M., Donnelly, M., Ismail, N. H., Hall, T., Wykes, K., Jack, J., Ngu, W. C., Morgan, P., Ruiz-Ramos, J., Ramirez, P., Gordon, M., Villarreal, E., Frasquet, J., Poveda-Andrés, J. L., Castellanos, A., Ijssennagger, C. E., ten Hoorn, S., van Wijk, A., van den Broek, J. M., Tuinman, P. R., Elmenshawy, A. M., Hammond, B. D., Gibbon, G., Belcham, T., Burton, K., Taniguchi, L. U., Ramos, F. J. S., Momma, A. K., Martins-Filho, A. P. R., Bartocci, J. J., Lopes, M. F. D., Sad, M. H., Rodrigues, C. M., Pires, E. M. C., Vieira, J. M., Barreto, J., Duarte, S. T., Taba, S., Miglioranza, D., Gund, D. P., Lordani, C. F., Capuzzo, M., Corte, F. Dalla, Terranova, S., Scaramuzzo, G., Fogagnolo, A., Bertacchini, S., Bellonzi, A., Ragazzi, R., Cruz, C., Nunes, A., Pereira, F. Seabra, Aragão, I., Cardoso, A. F., Santos, C., Malheiro, M. J., Castro, H., Cardoso, T., Paratz, J., Kenardy, J., Comans, T., Coyer, F., Thomas, P., Boots, R., Pereira, N., Vilas-Boas, A., Gomes, E., Torres, J., Carvalho, D., Molinos, E., Vales, C., Araújo, R., Karnatovskaia, L., Philbrick, K., Ognjen, G., Clark, M., Montero, R. Molina, Varas, J. Luján, Sánchez-Elvira, L. Alcázar, Delgado, C. Pintado, Díaz, P. Villa, Ruiz, B. Llorente, Guerrero, A. Pardo, Galache, J. A. Cambronero, Jiménez, R., Rebollo, S., Alejandro, O., Fernández, A., Moreno, S., Herrera, L., Ojados, A., Galindo, M., Murcia, J., Contreras, M., Sánchez-Argente, S., Bonilla, Y., Rodríguez, M. D., Allegue, J. M., Cakin, Ö., Parlak, H., Kirca, H., Mutlu, F., Aydınlı, B., Cengiz, M., Ramazanoglu, A., Jung, E.-J., Oh, S.-Y., Domenech, J. Cebrián, Montalvo, A. Pinos, Chornet, T. Ciges, Martinez, P. Concha, Ribas, M. Piñol, Costa, R. Gimeno, Ortega, A. Castellanos, Forbes, C., Prescott, H., Lal, A., Khan, F. A., Dela Pena, E. G., Dizon, J. S., Perez, P. P. P., Wong, C. M. J., Garach, M. Muñoz, Romero, O. Moreno, Puerta, R. Ramirez, Diaz, F. Acosta, Bailon, A. M. Perez, Pinel, A. Carranza, Maldonado, L. Peñas, Kalaiselvan, M. S., kumar, R. L. Siva, Renuka, M. K., Kumar, A. S. Arun, De Rosa, S., Ferrari, F., Checcacci, S. Carboni, Rigobello, A., Joannidis, M., Politi, F., Pellizzari, A., Bonato, R., Fernandez-Carmona, A., Macias-Guarasa, I., Gutierrez-Rodriguez, R., Martinez-Lopez, P., Diaz-Castellanos, M. A., Arias-Diaz, M., Aguilar-Alonso, E., Nikandish, R. N., Artemenko, V., Budnyuk, A., Bassi, G. Li, Senussi, T., Idone, F., Xiol, E. Aguilera, Travierso, C., Chiurazzi, C., Motos, A., Amaro, R., Hua, Y., Fernández-Barat, L., Ranzani, O. T., Bobi, Q., Rigol, M., Youn, A., Hwang, J. Gyung, Ossorio, M. E. Yuste, Figueira, H., Oliveira, R., Mota, A., Kamp, O., Cruciger, O., Aach, M., Kaczmarek, C., Waydhas, C., Schildhauer, T. A., Hamsen, U., Camprubí-Rimblas, M., Chimenti, L., Guillamat-Prats, R., Lebouvier, T., Bringué, J., Tijero, J., Gómez, M. N., Blanch, L., Tagliabue, G., Ji, M., Jagers, J. V. Suneby, Easton, P. A., Martins, A. M. C. R. P. F., Hong, J. Y., Shin, M. H., Park, M. S., Pomprapa, A., Hofferberth, M. B. T., Russ, M., Braun, W., Walter, M., Francis, R., Lachmann, B., Leonhardt, S., Landaverde-López, A., Canedo-Castillo, N. A., Esquivel-Chávez, A., Arvizu-Tachiquín, P. C., Baltazar-Torres, J. A., Cardoso, V., Krystopchuk, A., Castro, S., Melão, L., Firmino, S., Marreiros, A., Almaziad, S., Kubbara, A., Barnett, W., Nakity, R., Alamoudi, W., Altook, R., Tarazi, T., Fida, M., Safi, F., Assaly, R., Santini, A., Milesi, M., Maraffi, T., Pugni, P., Cavenago, M., Gattinoni, L., Protti, A., Perchiazzi, G., Borges, J. B., Bayat, S., Porra, L., Broche, L., Hedenstierna, G., Larsson, A., Roneus, A., Segelsjö, M., Vestito, M. C., Gremo, E., Nyberg, A., Castegren, M., Pikwer, A., Yoshida, T., Engelberts, D., Otulakowski, G., Katira, B., Post, M., Brochard, L., Amato, M. B. P., Koch, N., Hoellthaler, J., Mair, S., Phillip, V., Beitz, A., Baladrón, V., Villarejo, P., Steenstra, R. J., Banierink, H., Hof, J., van der Horst, I. C., Nijsten, M. W., Hoekstra, M., Sterz, F., Horvatits, K., Herkner, H., Kott, M., Zitta, K., Brandt, B., Schildhauer, C., Elke, G., Hummitzsch, L., Albrecht, M., González, L. Rey, Alonso, D. Cabestrero, Sánchez, R. de Pablo, Lucas, J. Higuera, Ferlitsch, A., Fauler, G., Trauner, M., Pischke, S., Fischer, L., Thaiss, F., Koch, M., Bangert, K., Lohse, A. W., Nashan, B., Sterneck, M., Faenza, S., Siniscalchi, A., Pierucci, E., Mancini, E., Ricci, D., Gemelli, C., Cuoghi, A., Magnani, S., Atti, M., Sotos, F., Cánovas, J., López, A., Burruezo, A., Torres, D., Herrera-Gutierrez, M. E., Barrueco-Francioni, J., Arias-Verdú, D., Lozano-Saez, R., Quesada-Garcia, G., Seller-Pérez, G., Figueiredo, A., Anzola, Y., Pereira, R., Bento, L., Lai, M., Deiana, M., Seller-Perez, G., Vardas, K., Ilia, S., Sertedaki, A., Charmadari, E., Stratakis, C. A., Briassouli, E., Goukos, D., Psarra, K., Botoula, E., Tsagarakis, S., Mageira, E., Routsi, C., Nanas, S., Campello, E., Radu, C. M., Su, H., Lam, Y. M., Willis, K., Pullar, V., Hubner, R. P., Tsang, J. L., de Guadiana-Romualdo, L. García, Rebollo-Acebes, S., Esteban-Torrella, P., Jiménez-Sánchez, R., Jiménez-Santos, E., Ortín-Freire, A., Hernando-Holgado, A., Albaladejo-Otón, M. D., Coelho, L., Rabello, L., Póvoa, P., Varis, E., Poukkanen, M., Jacob, S., Takala, J., Wilkman, E., Lundberg, O. H. M., Bergenzaun, L., Rydén, J., Rosenqvist, M., Melander, O., Chew, M. S., Kishihara, Y., Yasuda, H., Jimenez, R., Torrella, P. Esteban, Fernandez, A., Sanchez, S., Ortin, A., Prats, R. Guillamat, Aguilera, E., Marti, D., Fernandez, L., Ferrer, M., Lanziotti, V. S., Pulcheri, L., Ribeiro, M. O., Barbosa, A. P., e Silva, J. R. Lapa, Soares, M., Salluh, J. I. F., Marqués, M. Gil, Moreno, A. Puppo, Pizarraya, A. Gutierrez, Diaz, J. Pachón, Smani, Y., Connell, M. Mc, Zhang, L. A., Parker, R. S., Banerjee, I., Clermont, G., Norberg, E., Oras, J., Cuisinier, A., Maufrais, C., Payen, J. F., Nottin, S., Walther, G., Arib, S., Bilotta, F., Badenes, R., Rubulotta, F., Mirek, S., Monfort, B., Stazi, E., Roig, A. Lozano, Magnoni, S., Marando, M., Pifferi, S., Conte, V., Ortolano, F., Carbonara, M., Bertani, G., Scola, E., Cadioli, M., Triulzi, F., Colombo, A., Stocchetti, N., Rotzel, H. B., Lázaro, A. Serrano, Prada, D. Aguillón, Guimillo, M. Rodriguez, Piqueras, C. Sanchís, Guia, J. Romero, Simon, M. García, Arizmendi, A. Mesejo, Carratalá, A., El Maraghi, S., Yehia, A., Bakry, M., Shoman, A., Backes, F. N., Bianchin, M. M., Vieira, S. R. R., de Souza, A., Backes, A. N., Klein, C., Arunkumar, A. S., Lozano, A., Gallaher, C., Cattlin, S., Gordon, S., Picard, J., Fontana, V., Bond, O., Nobile, L., Mrozek, S., Delamarre, L., Capilla, F., Al-Saati, T., Fourcade, O., Dominguez-Berrot, A. M., Gonzalez-Vaquero, M., Vallejo-Pascual, M. E., Gupta, D., Ivory, B. D., Chopra, M., McCarthy, J., Felderhof, C. L., MacNeil, C., Maggiorini, M., Duska, F., Fumis, R. R. L., Junior, J. M. Vieira, Amarante, G., Skorko, A., Sanders, S., Aron, J., Kroll, R. J., Redfearn, C., Krishnan, P., Khalil, J. E., Kongpolprom, N., Gulia, V., Lourenço, E., Duro, C., Baptista, G., Alves, A., Arminda, B., Rodrigues, M., Hayward, J., Baldwin, F., Gray, R., Katinakis, P. A., Stijf, M., Ten Kleij, M., Jansen-Frederiks, M., Broek, R., de Bruijne, M., Spronk, P. E., Sinha, K., Luney, M., Palmer, K., Keating, L., Abu-Habsa, M., Bahl, R., Baskaralingam, N., Ahmad, A., Kanapeckaite, L., Bhatti, P., Glace, S., Jeyabraba, S., Lewis, H. F., Kostopoulos, A., Raja, M., West, A., Ely, A., Turkoglu, L. M., Zolfaghari, P., Baptista, J. P., Marques, M. P., Martins, P., Pimentel, J., Su, Y. C., Villacres, S., Stone, M. E., Parsikia, A., Medar, S., O’Dea, K. P., Porter, J., Tirlapur, N., Jonathan, J. M., Singh, S., Takata, M., McWhirter, E., Lyon, R., Hariz, M. L., Azmi, E., Alkhan, J., Movsisyan, V., Petrikov, S., Marutyan, Z., Aliev, I., Evdokimov, A., Antonucci, E., Merz, T., Hartmann, C., Calzia, E., Radermacher, P., Nußbaum, B., Huber-Lang, M., Gröger, M., Svoren-Jabalera, E., Davenport, E. E., Humburg, P., Knight, J., Hinds, C. J., Jun, I. J., Kim, W. J., Lee, E. H., Besch, G., Perrotti, A., Puyraveau, M., Baltres, M., Samain, E., Chocron, S., Pili-Floury, S., Plata-Menchaca, E. P., Sabater-Riera, J., Estruch, M., Boza, E., Toscana-Fernández, J., Bruguera-Pellicer, E., Ordoñez-Llanos, J., Pérez-Fernández, X. L., Cavaleiro, P., Tralhão, A., Arrigo, M., Lopes, J.-P., Lebrun, M., Cholley, B., PerezVela, J. L., MarinMateos, H., Rivera, J. J. Jimenez, Llorente, M. A. Alcala, De Marcos, B. Gonzalez, Fernandez, F. J. Gonzalez, Laborda, C. Garcia, Zamora, D. Fernandez, Delgado, J. C. Lopez, Imperiali, C., Dastis, M., Górka, J., Górka, K., Iwaniec, T., Frołow, M., Polok, K., Fronczek, J., Kózka, M., Musiał, J., Szczeklik, W., Sileli, M., Moursia, C., Maleoglou, H., Leleki, K., Uz, Z., Ince, Y., Papatella, R., Bulent, E., De Mol, B., Vicka, V., Gineityte, D., Ringaitiene, D., Norkiene, I., Sipylaite, J., Möller, C., Thomas-Rueddel, D. O., Vlasakov, V., Rochwerg, B., Theurer, P., Al Sibai, J. Zanabili, Camblor, P. Martinez, Fernandez, P. Alvarez, Gala, J. M. García, Guisasola, J. Silba, Tamura, T., Miyajima, I., Yamashita, K., Yokoyama, M., Dalampini, E., Nastou, M., Baddour, A., Ignatiadis, A., Asteri, T., Hathorn, K. E., Purtle, S. W., Viana, M. V., Tonietto, T. A., Gross, L. A., Costa, V. L., Tavares, A. L. J., Lisboa, B. O., Moraes, R. B., Vieira, S. R., Viana, L. V., Azevedo, M. J., Ceniccola, G. D., Pequeno, R. S. F., Holanda, T. P., Mendonça, V. S., Araújo, W. M. C., Carvalho, L. S. F., Segaran, E., Vickers, L., Brinchmann, K., Wignall, I., De Brito-Ashurst, I., del Olmo, R., Esteban, M. J., Vaquerizo, C., Carreño, R., Gálvez, V., Kaminsky, G., Nieto, B., Fuentes, M., De la Torre, M. A., Torres, E., Alonso, A., Velayos, C., Saldaña, T., Escribá, A., GRIP, J., Kölegård, R., Sundblad, P., Rooyackers, O., Naser, Ben, Jaziri, F., Jazia, A. Ben, Barghouth, M., Hentati, O., Skouri, W., El Euch, M., Mahfoudhi, M., Turki, S., Abdelghni, K. Ben, Abdallah, Ben, Maha, B. N. M., Lorente, M., Włudarczyk, A., Hałek, A., Bargouth, M., Bennasr, M., Abdelghani, K. Ben, Abdallah, T. Ben, Geenen, I. L., Parienti, J. J., Straaten, H. M. Oudemans-van, Shum, H. P., King, H. S., Chan, K. C., Yan, W. W., Londoño, J. Gonzalez, Cardenas, C. Lorencio, Pedrosa, M. Morales, Gubianas, C. Murcia, Bertolin, C. Fuster, Batllori, N. Vila, Sirvent, J. M., Mukhopadhyay, A., Chan, H. Y., Kowitlawakul, Y., Remani, D., Leong, C. S. F., Henry, C. J., Puthucheary, Z. A., Mendsaikhan, N., Begzjav, T., Lundeg, G., Dünser, M., Welsh, S. P., Guerra, E., Zerpa, M. C. l., Zechner, F., Berdaguer, F., Risso-Vazquez, A., Masevicius, F. D., Greaney, D., Magee, A., Fitzpatrick, G., Lugo-Cob, R. G., Tejeda-Huezo, B. C., Cano-Oviedo, A. A., Aydogan, M. S., Togal, T., Taha, A., Chai, H. Z., Kam, C., Razali, S. S. Yang, Sivasamy, V., Kuan, L. Y., Morales, M. A. Lopez, Pires, T., and Azevedo, L. C. P.
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Meeting Abstracts - Abstract
Introduction In addition to systemic hemodynamics, the management\ud of neurocritically ill patients is often informed by neuromonitoring. In\ud the absence of high-level evidence clinicians are often guided by personal\ud and local expertise. Little is known about practices as they pertain\ud to the use of such monitoring in patients with acute brain injury (ABI).\ud Objectives To investigate practices in bedside monitoring for ABI patients.\ud Particularly interested in differences among “neurointensivists”\ud (NIs; defined here as intensivists whose clinical practice is comprised\ud > 1/3 by neurocritical care) and other intensivists (OIs). Also, to\ud explore patterns specific to traumatic brain injury (TBI) and subarachnoid\ud hemorrhage (SAH), as well as preferences and availability of\ud particular technologies/devices.\ud Methods Electronic survey of 22 items including two case-based scenarios;\ud endorsed by SCCM (9,000 recipients) and ESICM (on-line\ud newsletter) in 2013. A sample size of 370 was calculated based on a\ud population of 10,000 physician members, a 5 % margin error, and\ud 95 % confidence interval. We summarized results using descriptive\ud statistics (proportions with 95 % confidence intervals). A chi-square\ud test was used to compare proportions of responses between NIs and\ud OIs with a significance p < 0.05.\ud Results There were 655 responders (66 % completion rate); 422(65 %)\ud were classified as OIs and 226(35 %) as NIs. More NIs follow\ud hemodynamic protocols for neurocritically-ill patients (56 % vs. 43 %, p\ud 0.001), in TBI (44.5 % vs. 33.3 %, p 0.007), and in SAH (38.1 % vs. 21.3 %,\ud p < 000.1). For delayed cerebral ischemia (DCI), more NIs target cardiac\ud index (CI) (35 % vs. 21 %, p 0.0001), and fluid responsiveness (62 % vs.\ud 53 %, p 0.03), use more bedside ultrasound (BUS) (42 % vs. 29 %, p\ud 0.005) and arterial waveform analysis (40 % vs. 29 %, p 0.02). For DCI\ud neuromonitoring, NIs use more angiography (57 % vs. 43 %, p 0.004),\ud TCD (46 % vs. 38 %, p 0.0001), and CTP (32 % vs.16 %, p 0.0001). For\ud CPP optimization in TBI, NIs use more arterial waveform analysis (45 %\ud vs. 35 %, p 0.019), and BUS (37 % vs. 27.7 %, p 0.023), while more OIs\ud monitor mixed venous oxygen saturation (54.1 % vs. 45 %, p 0.045). For\ud TBI neuromonitoring, NIs use more PbtO2 (28 % vs. 10 %, p 0.0001). In\ud the case scenario of raised ICP/low PbtO2, most employ analgosedation\ud (47 %) and osmotherapy (38 %). Fewer make use of preserved pressure\ud reactivity, particularly OIs (vasopressor use 23 % vs. 34 %, p 0.014).\ud Conclusions There is large heterogeneity in the use of monitoring protocols,\ud variables, and technologies/devices. “Neurointensivists” not only\ud employ more neuromonitoring but also more hemodynamic monitoring\ud in patients with acute brain injury. ICP/CPP remain the most commonly\ud followed neuro-variables in TBI patients, with low use of other\ud brain-physiology parameters, sugg
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- 2016
62. Genomic mapping of the MHC transactivator CIITA using an integrated ChIP-seq and genetical genomics
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Wong, D, Lee, W, Humburg, P, Makino, S, Lau, E, Naranbhai, V, Fairfax, BP, Chan, K, Plant, K, and Knight, JC
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- 2016
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63. Synergistic cooperation and crosstalk between MYD88L265P and mutations that dysregulate CD79B and surface IgM
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Wang, JQ, Jeelall, YS, Humburg, P, Batchelor, EL, Kaya, SM, Yoo, HM, Goodnow, CC, Horikawa, K, Wang, JQ, Jeelall, YS, Humburg, P, Batchelor, EL, Kaya, SM, Yoo, HM, Goodnow, CC, and Horikawa, K
- Abstract
CD79B and MYD88 mutations are frequently and simultaneously detected in B cell malignancies. It is not known if these mutations cooperate or how crosstalk occurs. Here we analyze the consequences of CD79B and MYD88L265P mutations individually and combined in normal activated mouse B lymphocytes. CD79B mutations alone increased surface IgM but did not enhance B cell survival, proliferation, or altered NF-κB responsive markers. Conversely, B cells expressing MYD88L265P decreased surface IgM coupled with accumulation of endoglycosidase H-sensitive IgM intracellularly, resembling the trafficking block in anergic B cells repeatedly stimulated by self-antigen. Mutation or overexpression of CD79B counteracted the effect of MYD88L265P. In B cells chronically stimulated by self-antigen, CD79B and MYD88L265P mutations in combination, but not individually, blocked peripheral deletion and triggered differentiation into autoantibody secreting plasmablasts. These results reveal that CD79B and surface IgM constitute a rate-limiting checkpoint against B cell dysregulation by MYD88L265P and provide an explanation for the co-occurrence of MYD88 and CD79B mutations in lymphomas.
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- 2017
64. Exploring the population dynamics of waterfowl hunters using a mark‐recapture approach
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Graham, Katherine A., Vrtiska, Mark P., Humburg, Dale D., Powell, Larkin A., Raedeke, Andrew H., Devers, Patrick K., and Chizinski, Christopher J.
- Abstract
The number of waterfowl hunters in the United States has declined since the 1980s despite relatively abundant waterfowl populations and liberal hunting regulations. Programs focused on recruiting, retaining, and reactivating (R3) waterfowl hunters have become important to avoid further losses in traditional revenue for habitat management and protection and political support for waterfowl conservation and management. We focus on 4 waterfowl hunter population vital rates (i.e., recruitment rate, retention probability, license purchase probability, realized population growth rate), which can be used to improve the effectiveness of waterfowl hunter R3 activities and initiatives by providing a deeper understanding of waterfowl hunter population dynamics to determine who programs should target, where programs should be targeted, and finally the evaluation of programs. To do so, we analyzed Nebraska state electronic license data from 2012–2019 using Pradel survival and recruitment models in a mark‐recapture framework. Female waterfowl hunter recruitment was higher than males; however, retention and license purchase probabilities were lower. Recruitment was highest in younger generations and retention highest in older generations. License purchase probabilities were highest among those in the oldest and youngest generations. The availability of hunting opportunity increased license purchase probabilities but had a minimal influence on retention and no association with recruitment. There were weak relationships between rurality and recruitment, and retention and license purchase probabilities. Finally, belonging to Ducks Unlimited was positively associated with higher license purchase and retention probabilities. Targeting an increase in license purchase probability by promoting social support for hunters through conservation organization membership should be a focus of waterfowl hunter R3 efforts to have the greatest influence on increasing waterfowl hunter participation. Programs focused on recruiting, retaining, and reactivating (R3) waterfowl hunters have become critical to avoid further losses in traditional revenue for habitat management and protection and political support for waterfowl management. We analyzed Nebraska state electronic license data from 2012—2019 using Pradel survival and recruitment models in a mark‐recapture framework to estimate waterfowl hunter population dynamics. We found that R3 efforts focused on promoting social support for hunters through conservation organization membership and targeting an increase in license purchase probability will likely be most influential on waterfowl hunter population dynamics.
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- 2024
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65. A Community Concerns Analysis: A Basis for Justifying Business Education Programs in the 1980s.
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Humburg, Renae Bygel
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A concerns analysis is a method of data collection for program improvement budget requests. It is also a public relations tool, opening lines of communication between the school and the community. Data sources for this analysis include employer, parent, and student surveys and the community forum. (SK)
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- 1983
66. The Bayes rule is not sufficient to justify or describe inductive reasoning
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Humburg, Jürgen
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- 1987
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67. The solution of Hempel's raven paradox in rudolf Carnap's system of inductive logic
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Humburg, Jürgen
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- 1986
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68. Foundations of a new system of probability theory
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Humburg, Jürgen
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- 1986
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69. Clinical heterogeneity in infantile galactosialidosis
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Sewell, A. C., Pontz, B. F., Weitzel, D., and Humburg, C.
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- 1987
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70. Emissionsminderung von kraftstoffbetriebenen Fahrzeugheizungen.
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Blaschke, Walter, Humburg, Michael, Jensen, Hans, and Pfister, Wolfgang
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- 2018
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71. Propelled Abrasive Grit for Weed Control in Organic Silage Corn.
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Erazo-Barradas, Mauricio, Clay, Sharon A., Forcella, Frank, and Humburg, Daniel
- Abstract
Weed management in organic farming requires many strategies to accomplish acceptable control and maintain crop yields. This 2-yr field study used air propelled abrasive grit for in-row weed control in organically certified silage corn (Zea mays L.). Corncob grit was applied as a single application at corn vegetative growth stages V1 (one true leaf; numbers correspond to number of true leaves at the corn vegetative stage), V3, or V5 (in 2013) and V3, V5, and V7 (in 2014) and in double and triple combinations at these stages. Between-row weed control was accomplished by flaming or cultivation after the last grit application. Grit effects on weed efficacy and silage yield were quantified and compared with hand-weeded and season-long weedy treatments. Grit applications decreased in-row weed biomass by >80% and increased yield up to 250% when compared with the weedy check. Single early applications (V1 and V3) increased yield, with additional treatments decreasing end-of-season weed density and biomass. Single late grit applications (V5 and V7) also decreased weed biomass, but silage yields were reduced compared with hand-weeded and early treatments. Early grit applications may have value for growers to control in-row annual weeds in organic silage corn without soil disturbance. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
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72. Newly Developed Dopamine D3Receptor Antagonists, R-VK4-40 and R-VK4-116, Do Not Potentiate Cardiovascular Effects of Cocaine or Oxycodone in Rats▪
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Jordan, Chloe J., Humburg, Bree A., Thorndike, Eric B., Shaik, Anver Basha, Xi, Zheng-Xiong, Baumann, Michael H., Newman, Amy Hauck, and Schindler, Charles W.
- Abstract
Opioid and cocaine abuse are major public health burdens. Existing medications for opioid use disorder are limited by abuse liability and side effects, whereas no treatments are currently approved in the United States for cocaine use disorder. Dopamine D3receptor (D3R) antagonists have shown promise in attenuating opioid and cocaine reward and mitigating relapse in preclinical models. However, translation of D3R antagonists to the clinic has been hampered by reports that the D3R antagonists GSK598,809 (5-(5-((3-((1S,5R)-1-(2-fluoro-4-(trifluoromethyl)phenyl)-3-azabicyclo[3.1.0]hexan-3-yl)propyl)thio)-4-methyl-4H-1,2,4-triazol-3-yl)-4-methyloxazole) and SB-277,011A (2-(2-((1r,4r)-4-(2-oxo-2-(quinolin-4-yl)ethyl)cyclohexyl)ethyl)-1,2,3,4-tetrahydroisoquinoline-6-carbonitrile) have adverse cardiovascular effects in the presence of cocaine. Recently, we developed two structurally novel D3R antagonists, R-VK4-40 and R-VK4-116, which are highly selective for D3R and display translational potential for treatment of opioid use disorder. Here, we tested whether R-VK4-40 ((R)-N-(4-(4-(2-Chloro-3-ethylphenyl)piperazin-1-yl)-3-hydroxybutyl)-1H-indole-2-carboxamide) and R-VK4-116 ((R)-N-(4-(4-(3-Chloro-5-ethyl-2-methoxyphenyl)piperazin-1-yl)-3-hydroxybutyl)-1H-indole-2-carboxamide) have unwanted cardiovascular effects in the presence of oxycodone, a prescription opioid, or cocaine in freely moving rats fitted with surgically implanted telemetry transmitters. We also examined cardiovascular effects of the D3R antagonist, SB-277,011A, and L-741,626 (1-((1H-indol-3-yl)methyl)-4-(4-chlorophenyl)piperidin-4-ol), a dopamine D2receptor–selective antagonist, for comparison. Consistent with prior reports, SB-277,011A increased blood pressure, heart rate, and locomotor activity alone and in the presence of cocaine. L-741,626 increased blood pressure and heart rate. In contrast, R-VK4-40 alone dose-dependently reduced blood pressure and heart rate and attenuated oxycodone-induced increases in blood pressure and oxycodone or cocaine-induced increases in heart rate. Similarly, R-VK4-116 alone dose-dependently reduced cocaine-induced increases in blood pressure and heart rate. These results highlight the safety of new D3R antagonists and support the continued development of R-VK4-40 and R-VK4-116 for the treatment of opioid and cocaine use disorders.
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- 2019
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73. Die Problematik apriorischer Wahrscheinlichkeiten im System der induktiven Logik von Rudolf Carnap
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Humburg, Jürgen
- Published
- 1971
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74. Die Berechnung der Spaltstreuung in synchronen und asynchronen Maschinen
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Humburg, Karl
- Published
- 1940
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75. Die Berechnung von Kondensatordurchführungen
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Humburg, K.
- Published
- 1923
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76. Wahrscheinlichkeits- und Wettbegriff
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Humburg, J.
- Published
- 1972
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77. Begriff und Aufteilung der Streuung bei synchronen und asynchronen Maschinen
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Humburg, Karl
- Published
- 1940
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78. Das Stromdiagramm der Asynchronmaschine
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Humburg, K. and Voigt, H.
- Published
- 1935
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79. Effects of blood pressure lowering for the prevention of dementia: meta‐analysis of individual patient data from five seminal randomised controlled trials involving 28008 participants.
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Peters, Ruth, Xu, Ying, Fitzgerald, Oisin, Aung, Htein Linn, Beckett, Nigel S., Bulpitt, Christopher J., Chalmers, John, Forette, Françoise, Gong, Jessica, Harris, Katie, Humburg, Peter, Matthews, Fiona E, Staessen, Jan, Thijs, Lutgarde, Tzourio, Christophe, Warwick, Jane, Woodward, Mark, and Anderson, Craig S.
- Abstract
Background: Observational studies indicate U‐shaped associations of blood pressure (BP) and incident dementia in older age, but randomised controlled trials of BP lowering treatment show mixed results on this outcome in hypertensive patients. We undertook a pooled individual participant data analysis of five seminal double‐blind placebo‐controlled randomised trials to better define the effects of BP lowering treatment for the prevention of dementia and cognitive decline. Methods: Multilevel logistic regression was used to evaluate the treatment effect on incident dementia. Effect modification was assessed for key population characteristics including age, baseline systolic BP, sex, and presence of prior stroke. Mediation analysis was used to quantify the contribution of trial medication and changes in systolic and diastolic BP on risk of dementia. Results: The total sample included 28,008 individuals recruited from 20 countries. After a median follow‐up of 4.3 years, there were 861 cases of incident dementia. Multilevel logistic regression reported an adjusted odds ratio 0.87 (95% confidence interval 0.75, 0.99) in favour of antihypertensive treatment reducing risk of incident dementia with a mean BP lowering of 10/4mmHg. Further multinomial regression taking account of death as a competing risk found similar results. There was no effect modification by age or sex. Mediation analysis confirmed the greater fall in BP in the actively treated group was associated with a greater reduction in dementia risk. Conclusion: Using data from double‐blind placebo‐controlled clinical trials, we provide evidence in the first single‐stage individual participant meta‐analysis to support benefits of antihypertensive treatment in late‐mid and later life to lower the risk of dementia. Questions remain as to the potential for additional BP lowering in those with already well‐controlled hypertension and of antihypertensive treatment commenced earlier in the life‐course to reduce the long‐term risk of dementia. [ABSTRACT FROM AUTHOR]
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- 2022
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80. The Influence of Pain Hypersensitivity and Psychological Factors on Pain and Disability in the Transition From Acute to Chronic Low Back Pain: A Longitudinal Exploratory Investigation and Cluster Analysis
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Chang, Wei-Ju, Jenkins, Luke C., Humburg, Peter, and Schabrun, Siobhan M.
- Abstract
Pain hypersensitivity is present in some people with acute low back pain (LBP) and thought to be involved in the development of chronic LBP. Early evidence suggests that pain hypersensitivity in acute LBP precedes poor long-term outcome. We aimed to examine whether the presence of pain hypersensitivity in acute LBP influenced recovery status at 6 months and differentiated how pain and disability changed over time. Participants with acute nonspecific LBP (<6 weeks after pain onset, N = 118) were included in this longitudinal study. Quantitative sensory testing, including pressure and heat pain thresholds, and conditioned pain modulation and questionnaires were compared at baseline and longitudinally (at 3 and 6 months) between recovered and unrecovered participants. Using k-means clustering, we identified subgroups based on baseline sensory measures alone, and in combination with psychological factors, and compared pain and disability outcomes between subgroups. Sensory measures did not differ at baseline or longitudinally between recovered (N = 50) and unrecovered (N = 68) participants. Subgrouping based on baseline sensory measures alone did not differentiate pain or disability outcomes at any timepoint. Participants with high psychological distress at baseline (N = 19) had greater disability, but not pain, at all timepoints than those with low psychological distress, regardless of the degrees of pain sensitivity. Our findings suggest that pain hypersensitivity in acute LBP does not precede poor recovery at 6 months or differentiate how pain and disability change over time. High psychological distress during acute LBP is associated with unremitting and pronounced disability, while pain severity is unaffected.
- Published
- 2024
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81. Choice of transcripts and software has a large effect on variant annotation
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McCarthy, DJ, Humburg, P, Kanapin, A, Rivas, MA, Gaulton, K, Cazier, J-B, Donnelly, P, McCarthy, DJ, Humburg, P, Kanapin, A, Rivas, MA, Gaulton, K, Cazier, J-B, and Donnelly, P
- Abstract
BACKGROUND: Variant annotation is a crucial step in the analysis of genome sequencing data. Functional annotation results can have a strong influence on the ultimate conclusions of disease studies. Incorrect or incomplete annotations can cause researchers both to overlook potentially disease-relevant DNA variants and to dilute interesting variants in a pool of false positives. Researchers are aware of these issues in general, but the extent of the dependency of final results on the choice of transcripts and software used for annotation has not been quantified in detail. METHODS: This paper quantifies the extent of differences in annotation of 80 million variants from a whole-genome sequencing study. We compare results using the RefSeq and Ensembl transcript sets as the basis for variant annotation with the software Annovar, and also compare the results from two annotation software packages, Annovar and VEP (Ensembl's Variant Effect Predictor), when using Ensembl transcripts. RESULTS: We found only 44% agreement in annotations for putative loss-of-function variants when using the RefSeq and Ensembl transcript sets as the basis for annotation with Annovar. The rate of matching annotations for loss-of-function and nonsynonymous variants combined was 79% and for all exonic variants it was 83%. When comparing results from Annovar and VEP using Ensembl transcripts, matching annotations were seen for only 65% of loss-of-function variants and 87% of all exonic variants, with splicing variants revealed as the category with the greatest discrepancy. Using these comparisons, we characterised the types of apparent errors made by Annovar and VEP and discuss their impact on the analysis of DNA variants in genome sequencing studies. CONCLUSIONS: Variant annotation is not yet a solved problem. Choice of transcript set can have a large effect on the ultimate variant annotations obtained in a whole-genome sequencing study. Choice of annotation software can also have a substantial eff
- Published
- 2014
82. Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study.
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Davenport, Emma E, Burnham, Katie L, Radhakrishnan, Jayachandran, Humburg, Peter, Hutton, Paula, Mills, Tara C, Rautanen, Anna, Gordon, Anthony C, Garrard, Christopher, Hill, Adrian V S, Hinds, Charles J, and Knight, Julian C
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SEPSIS ,COHORT analysis ,GENE expression - Abstract
Summary Background Effective targeted therapy for sepsis requires an understanding of the heterogeneity in the individual host response to infection. We investigated this heterogeneity by defining interindividual variation in the transcriptome of patients with sepsis and related this to outcome and genetic diversity. Methods We assayed peripheral blood leucocyte global gene expression for a prospective discovery cohort of 265 adult patients admitted to UK intensive care units with sepsis due to community-acquired pneumonia and evidence of organ dysfunction. We then validated our findings in a replication cohort consisting of a further 106 patients. We mapped genomic determinants of variation in gene transcription between patients as expression quantitative trait loci (eQTL). Findings We discovered that following admission to intensive care, transcriptomic analysis of peripheral blood leucocytes defines two distinct sepsis response signatures (SRS1 and SRS2). The presence of SRS1 (detected in 108 [41%] patients in discovery cohort) identifies individuals with an immunosuppressed phenotype that included features of endotoxin tolerance, T-cell exhaustion, and downregulation of human leucocyte antigen (HLA) class II. SRS1 was associated with higher 14 day mortality than was SRS2 (discovery cohort hazard ratio (HR) 2·4, 95% CI 1·3–4·5, p=0·005; validation cohort HR 2·8, 95% CI 1·5–5·1, p=0·0007). We found that a predictive set of seven genes enabled the classification of patients as SRS1 or SRS2. We identified cis-acting and trans-acting eQTL for key immune and metabolic response genes and sepsis response networks. Sepsis eQTL were enriched in endotoxin-induced epigenetic marks and modulated the individual host response to sepsis, including effects specific to SRS group. We identified regulatory genetic variants involving key mediators of gene networks implicated in the hypoxic response and the switch to glycolysis that occurs in sepsis, including HIF1α and mTOR, and mediators of endotoxin tolerance, T-cell activation, and viral defence. Interpretation Our integrated genomics approach advances understanding of heterogeneity in sepsis by defining subgroups of patients with different immune response states and prognoses, as well as revealing the role of underlying genetic variation. Our findings provide new insights into the pathogenesis of sepsis and create opportunities for a precision medicine approach to enable targeted therapeutic intervention to improve sepsis outcomes. Funding European Commission, Medical Research Council (UK), and the Wellcome Trust. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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83. Implementing the 2012 North American Waterfowl Management Plan revision: Populations, habitat, and people
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Humburg, Dale D., Anderson, Michael G., Brasher, Michael G., Carter, Michael F., Eadie, John M., Fulton, David C., Johnson, Fred A., Runge, Michael C., and Vrtiska, Mark P.
- Abstract
The North American Waterfowl Management Plan (NAWMP) has established a model for wildlife conservation planning over the last 3 decades. Management at a continental scale, leveraged funding, regional partnerships, and a strong science basis have been notable features. Periodic updates to the NAWMP occurred since implementation in 1986; however, a fundamental revision was accomplished in 2012 after extensive stakeholder engagement. An explicit fundamental goal for waterfowl conservation supporters was added in 2012, complementing existing goals for sustainable populations and sufficient habitat found in previous updates. We present a synopsis of progress toward implementation of the 2012 NAWMP and challenge the waterfowl management community to continue with meaningful steps toward achieving NAWMP goals. Adding goals and objectives for supporters increases potential relevance of NAWMP; however, it also presents a level of complexity that was not entirely anticipated. Additionally, the 2012 NAWMP recognized that traditional support from waterfowl hunters alone will not be sufficient to support waterfowl conservation in the future. Simultaneous consideration of multiple objectives, although implicit before, now is a specific focus for habitat and harvest management affecting hunters and other users of the waterfowl resource. The waterfowl management community is faced with revisiting objectives and management actions related to harvest regulations, landscape priorities, habitat conservation, and public engagement to garner broader support. These persistent management challenges are tangible and relevant candidates for greater integration. Ultimately, the structures and processes supporting waterfowl management also will need to be reconsidered. © 2017 The Wildlife Society. The North American Waterfowl Management Plan (NAWMP), revised in 2012, acknowledged the fundamental importance of conservation supporters (i.e., hunters, bird‐watchers, others who actively support conservation). Explicitly including social goals and objectives in the NAWMP assures greater relevance; however, integrating these goals with those for waterfowl populations and habitat increases complexity considerably.
- Published
- 2018
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84. Synergistic cooperation and crosstalk between MYD88L265P and mutations that dysregulate CD79B and surface IgM
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Wang, James Q., Jeelall, Yogesh S., Humburg, Peter, Batchelor, Emma L., Kaya, Sarp M., Yoo, Hee Min, Goodnow, Christopher C., and Horikawa, Keisuke
- Abstract
CD79B and MYD88 mutations are frequently and simultaneously detected in B cell malignancies. It is not known if these mutations cooperate or how crosstalk occurs. Here we analyze the consequences of CD79B and MYD88L265P mutations individually and combined in normal activated mouse B lymphocytes. CD79B mutations alone increased surface IgM but did not enhance B cell survival, proliferation, or altered NF-κB responsive markers. Conversely, B cells expressing MYD88L265P decreased surface IgM coupled with accumulation of endoglycosidase H–sensitive IgM intracellularly, resembling the trafficking block in anergic B cells repeatedly stimulated by self-antigen. Mutation or overexpression of CD79B counteracted the effect of MYD88L265P. In B cells chronically stimulated by self-antigen, CD79B and MYD88L265P mutations in combination, but not individually, blocked peripheral deletion and triggered differentiation into autoantibody secreting plasmablasts. These results reveal that CD79B and surface IgM constitute a rate-limiting checkpoint against B cell dysregulation by MYD88L265P and provide an explanation for the co-occurrence of MYD88 and CD79B mutations in lymphomas.
- Published
- 2017
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85. Two artefacts with cupules from Early Pleistocene terraces of the Rhine, Germany.
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HUMBURG, CHRISTIAN
- Abstract
The article discusses the discovery of the two artefacts with cupules from Early Pleistocene terraces of the Rhine, Germany. The gravels are found to have been frequently cut into by construction activities and as building materials. It refers to the stone artefacts found at different levels and rock formations, such as siliceous limestone, mottled sandstone, quarzite, quartz, basalt and granite.
- Published
- 2018
86. Dealing With Deaths in Clinical Trials and Meta-Analyses.
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JMcCaughey, Euan, Humburg, Peter, JMcLachlan, Angus, and Gutiérrez-Arias, Ruvistay E.
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RESPIRATORY muscle physiology ,CRITICALLY ill ,PATIENTS ,TREATMENT duration ,ARTIFICIAL respiration ,ELECTRIC stimulation - Published
- 2021
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87. Brucellosis and thrombosis of the inferior vena cava
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Rüegger, Kristina, Tarr, Philip, Karatolios, Konstantinos, Humburg, Jörg, Hügli, Rolf, and Jeanneret, Christina
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Abstract.We describe the case of a 23-year old woman with a newly diagnosed thrombosis of the inferior vena cava associated with a Brucella melitensis infection. We suggest possible mechanisms leading to brucellosis-associated venous thrombosis and review 14 previously reported cases.
- Published
- 2017
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88. Learning and adaptation in waterfowl conservation: By chance or by design?
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Johnson, Fred A., Case, David J., and Humburg, Dale D.
- Abstract
The most recent revision of the North American Waterfowl Management Plan seeks to increase the adaptive capacity of the management enterprise to cope with accelerating changes in climate, land‐use patterns, agency priorities, and the waterfowl and wetlands constituency. Institutional and cultural changes of the magnitude envisioned are necessarily slow, messy processes, involving many actors who at a minimum must agree on the need for change. Waterfowl conservation now finds itself in the transition zone between business as usual and some new mode of operation. There are at least 2 different perspectives of this transition: one focuses on process, accountability, and planning for change; another focuses on solutions generated from an organic process of creativity, information sharing, and risk‐taking. Both of these views have something to contribute, but some in the wildlife management enterprise may tend to focus more on the first view. We suggest that ideas from panarchy theory, especially those related to the behaviors of complex adaptive systems, can help waterfowl managers better understand and foster the institutional changes they seek. © 2016 The Wildlife Society. The most recent revision of the North American Waterfowl Management Plan seeks to increase the adaptive capacity of the management enterprise to cope with accelerating changes in climate, land‐use patterns, agency priorities, and the waterfowl and wetlands constituency. Ideas from panarchy theory, especially those related to the behaviors of complex adaptive systems, may help waterfowl managers better understand and foster the institutional changes they seek.
- Published
- 2016
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89. Sex differences in the serum proteomic profile during acute low back pain – A preliminary study of the relationship to future low back pain
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Jenkins, Luke C, Chang, Wei-Ju, Humburg, Peter, Wasinger, Valerie C, Stone, Laura S, Dorsey, Susan G, Renn, Cynthia, Starkweather, Angela, and Schabrun, Siobhan M
- Abstract
The molecular processes driving the transition from acute to chronic low back pain (LBP) remain poorly understood and are likely to be sexually dimorphic. This study aimed to explore sex-differences in the serum proteomic profile of people experiencing an acute LBP episode and determine if serum protein concentrations were associated with three-month outcome. Serum samples were collected through venepuncture from 30 female and 29 male participants experiencing an acute LBP episode. Serum samples underwent trypsin digestion and fractionation using hydrophobic interaction chromatography and were then analysed using mass-spectrometry (MS). MS spectra were searched in the Swissprot database for protein identification. Sex differences in protein abundance changes were evident upon inspection of fold changes. Multivariable data analysis identified 21 serum proteins during the acute episode that correctly classified 93% of males and 23 serum proteins that correctly classified 90% of females with ongoing LBP at three months. Pathway analysis suggested the differentially expressed proteins during acute LBP were frequently involved in immune, inflammatory, complement or coagulation responses. This data provides preliminary evidence that biological processes during an acute LBP episode may contribute to resolution, or persistence, of LBP symptoms at three months, however, these processes differ between males and females.
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- 2023
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90. An empirical evaluation of landscape energetic models: Mallard and American black duck space use during the non-breeding period
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Beatty, William S., Webb, Elisabeth B., Kesler, Dylan C., Naylor, Luke W., Raedeke, Andrew H., Humburg, Dale D., Coluccy, John M., and Soulliere, Gregory J.
- Abstract
Bird conservation Joint Ventures are collaborative partnerships between public agencies and private organizations that facilitate habitat management to support waterfowl and other bird populations. A subset of Joint Ventures has developed energetic carrying capacity models (ECCs) to translate regional waterfowl population goals into habitat objectives during the non-breeding period. Energetic carrying capacity models consider food biomass, metabolism, and available habitat to estimate waterfowl carrying capacity within an area. To evaluate Joint Venture ECCs in the context of waterfowl space use, we monitored 33 female mallards (Anas platyrhynchos) and 55 female American black ducks (A. rubripes) using global positioning system satellite telemetry in the central and eastern United States. To quantify space use, we measured first-passage time (FPT: time required for an individual to transit across a circle of a given radius) at biologically relevant spatial scales for mallards (3.46?km) and American black ducks (2.30?km) during the non-breeding period, which included autumn migration, winter, and spring migration. We developed a series of models to predict FPT using Joint Venture ECCs and compared them to a biological null model that quantified habitat composition and a statistical null model, which included intercept and random terms. Energetic carrying capacity models predicted mallard space use more efficiently during autumn and spring migrations, but the statistical null was the top model for winter. For American black ducks, ECCs did not improve predictions of space use; the biological null was top ranked for winter and the statistical null was top ranked for spring migration. Thus, ECCs provided limited insight into predicting waterfowl space use during the non-breeding season. Refined estimates of spatial and temporal variation in food abundance, habitat conditions, and anthropogenic disturbance will likely improve ECCs and benefit conservation planners in linking non-breeding waterfowl habitat objectives with distribution and population parameters. Published 2015. This article is a U.S. Government work and is in the public domain in the USA.
- Published
- 2015
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91. Species Associations and Habitat Influence the Range-Wide Distribution of Breeding Canada Geese (Branta canadensis interior) on Western Hudson Bay.
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REITER, MATTHEW E., ANDERSEN, DAVID E., RAEDEKE, ANDREW H., and HUMBURG, DALE D.
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GEESE ,NEST building ,BIRD populations ,BIRD declines ,BIRD habitats ,SNOW goose - Abstract
The article discusses the findings of a study to determine how inter- and intra-species interactions affect the nesting distribution of Eastern Prairie Population (EPP) Canada Geese. It notes several predictive factors that changed the spatial distribution of EPP Canada Geese on the western Hudson Bay including nesting habitat type, distance of the habitat from Hudson Bay, and Lesser Snow Goose nest density. The study shows a decline in Canada Geese population when Lesser Snow Geese increased.
- Published
- 2013
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92. Nutzfahrzeug-Standheizung mit Biodiesel.
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Humburg, Michael, Krähling, Thomas, Pfister, Wolfgang, and Wetzel, Andreas
- Published
- 2008
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93. Genomic mapping of the MHC transactivator CIITA using an integrated ChIP-seq and genetical genomics approach
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Wong, Daniel, Lee, Wanseon, Humburg, Peter, Makino, Seiko, Lau, Evelyn, Naranbhai, Vivek, Fairfax, Benjamin, Chan, Kenneth, Plant, Katharine, and Knight, Julian
- Abstract
The master transactivator CIITA is essential to the regulation of Major Histocompatibility Complex (MHC) class II genes and an effective immune response. CIITA is known to modulate a small number of non-MHC genes involved in antigen presentation such as CD74and B2Mbut its broader genome-wide function and relationship with underlying genetic diversity has not been resolved. We report the first genome-wide ChIP-seq map for CIITA and complement this by mapping inter-individual variation in CIITA expression as a quantitative trait. We analyse CIITA recruitment for pathophysiologically relevant primary human B cells and monocytes, resting and treated with interferon-gamma, in the context of the epigenomic regulatory landscape and DNA-binding proteins associated with the CIITA enhanceosome including RFX, CREB1/ATF1 and NFY. We confirm recruitment to proximal promoter sequences in MHC class II genes and more distally involving the canonical CIITA enhanceosome. Overall, we map 843 CIITA binding intervals involving 442 genes and find 95% of intervals are located outside the MHC and 60% not associated with RFX5 binding. Binding intervals are enriched for genes involved in immune function and infectious disease with novel loci including major histone gene clusters. We resolve differentially expressed genes associated in transwith a CIITAintronic sequence variant, integrate with CIITA recruitment and show how this is mediated by allele-specific recruitment of NF-kB. Our results indicate a broader role for CIITA beyond the MHC involving immune-related genes. We provide new insights into allele-specific regulation of CIITA informative for understanding gene function and disease.
- Published
- 2014
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94. Effects of satellite transmitters on captive and wild mallards
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Kesler, Dylan C., Raedeke, Andrew H., Foggia, Jennifer R., Beatty, William S., Webb, Elisabeth B., Humburg, Dale D., and Naylor, Luke W.
- Published
- 2014
- Full Text
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95. The relationship between mandibular advancement, tongue movement, and treatment outcome in obstructive sleep apnea
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Jugé, Lauriane, Knapman, Fiona L, Humburg, Peter, Burke, Peter G R, Lowth, Aimee B, Brown, Elizabeth, Butler, Jane E, Eckert, Danny J, Ngiam, Joachim, Sutherland, Kate, Cistulli, Peter A, and Bilston, Lynne E
- Published
- 2022
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96. Sexuelle Dysfunktion
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Humburg, Jörg
- Abstract
Sexuelle Dysfunktion betrifft zwischen 20 bis 50 % aller Frauen. Ihre Ursachen sind das Resultat gestörter komplexer neurovaskulärer Abläufe, neben vaskulären und muskulären können auch neurogene, psychogene und endokrine Ursachen vorliegen. Sexuelle Dysfunktion bei Beckenbodeninsuffizienz kann einerseits durch anatomische und funktionelle Veränderungen hervorgerufen werden, andererseits in Folge ihrer Therapie auftreten. Bei einer Urininkontinenz tritt sie häufig auf, ist dabei abhängig vom Schweregrad der Inkontinenz, aber unabhängig von der Form der Urininkontinenz. Ein gleichzeitig vorliegender Deszenus hat einen negativ kumulativen Effekt auf Libido, sexuelle Erregung und Orgasmus. Aufgrund der vielfältigen Ursachen ist die Behandlung schwierig und ein interdisziplinärer Ansatz ist sinnvoll. Eine postoperativ auftretende sexuelle Dysfunktion ist ein häufiges Problem und ihr Auftreten ist unabhängig von der Art der gewählten chirurgischen Technik. Ein subjektiver patientinnenorientierter Ansatz ist in der präoperativen Beratung Erfolg versprechend.
- Published
- 2010
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97. Die postpartale Harnretention – klinisch bedeutungslos?
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Humburg, Jörg
- Abstract
Die postpartale Harnretention ist eine geburtshilfliche Komplikation, die nach Spontangeburt, vaginaloperativer Entbindung, aber auch Kaiserschnitt auftreten kann. Die Inzidenz variiert bei fehlender einheitlicher Definition stark. Der Spontanverlauf ist im Allgemeinen günstig. Da jedoch schon eine einmalige Überdehnung der Blase zu einer Blasenschädigung mit persistierender Miktionsstörung führen kann, ist die frühzeitige Erkennung und Einleitung entsprechender Maßnahmen notwendig. Die Prognose ist im Allgemeinen gut, Fälle mit prolongiertem Verlauf sind jedoch hinsichtlich Therapie und Betreuung anspruchsvoll, da allgemeingültige, evidenzbasierte Guidelines fehlen. Die Ätiologie ist unklar, scheint jedoch zumindest teilweise durch den Druck des vorangehenden Teils subpartu bedingt zu sein, der zur Harnretention infolge Ödembildung am Blasenhals oder zu einer Neurapraxie führt. Neben konservativen, die miktionsfördernden Maßnahmen, ist die Entlastung der Blase durch Katheterisierung zentraler Pfeiler der Therapie.
- Published
- 2008
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98. Effectiveness of Spinning-Wing Decoys Varies Among Dabbling Duck Species and Locations
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ACKERMAN, JOSHUA T., EADIE, JOHN M., SZYMANSKI, MICHAEL L., CASWELL, JASON H., VRTISKA, MARK P., RAEDEKE, ANDREW H., CHECKETT, J. MICHAEL, AFTON, ALAN D., MOORE, THOMAS G., CASWELL, F. DALE, WALTERS, RICH A., HUMBURG, DALE D., and YEE, JULIE L.
- Abstract
Abstract:Spinning-wing decoys are strong attractants to ducks and increase kill rates over traditional decoying methods. However, it is unknown whether all duck species are attracted similarly to spinning-wing decoys and whether the effectiveness of these decoys changes with latitude. We examined the effectiveness of spinning-wing decoys for 9 species of dabbling ducks during 545 experimental hunts in California (1999–2000), Minnesota (2002), Manitoba (2001–2002), Nebraska (2000–2002), Missouri (2000–2001), and Arkansas (2001–2003). During each experimental hunt, we systematically alternated between 2 paired decoy treatments every 15–30 min (depending on study site): traditional decoys only and traditional decoys with a spinning-wing decoy. Overall, 70.2% (n = 1,925) of dabbling ducks were harvested (shot and retrieved) when spinning-wing decoys were turned on, ranging from 63.6% (n = 187) in Missouri to 76.4% (n = 356) in Minnesota. Effectiveness of spinning-wing decoys increased with latitude of study sites. Proportions of ducks shot when spinning-wing decoys were turned on differed among species, from a low of 50.0% (n = 8) for cinnamon teal (Anas cyanoptera)to a high of 79.0% (n = 119) for American wigeon (A. americana). The probability of being shot when spinning-wing decoys were turned on increased with annual survival rates among species; for example, spinning-wing decoys were more effective for American wigeon and mallard (A. platyrhynchos) than they were for cinnamon teal and American green-winged teal (A. crecca). Effectiveness of spinning-wing decoys did not differ consistently by age or sex of harvested ducks. Our results indicate that the effectiveness of spinning-wing decoys differs among duck species and changes with latitude; thus, consideration of these effects may be warranted when setting harvest regulations and methods of take.
- Published
- 2006
- Full Text
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99. SURVIVAL, MOVEMENTS, AND HARVEST OF EASTERN PRAIRIE POPULATION CANADA GEESE
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SHEAFFER, SUSAN E., RUSCH, DONALD H., HUMBURG, DALE D., LAWRENCE, JEFFERY S., ZENNER, GUY G., GILLESPIE, MURRAY M., CASWELL, F. DALE, WILDS, STEVE, and YAICH, SCOTT C.
- Abstract
Abstract: The Eastern Prairie Population (EPP) of Canada geese (Branta canadensis interior) nests in the Hudson Bay lowlands of Manitoba and migrates through south‐central Manitoba, western Minnesota, and Iowa, with a wintering terminus primarily in Missouri, Arkansas, and southern Illinois. The southern range of the EPP historically extended through Arkansas and along coastal southwestern Louisiana and Texas. However, during the 1950s and 1960s a progressive northern shift in wintering distribution occurred as numbers of geese wintering in Louisiana and Arkansas declined while numbers wintering in Missouri increased. Continued temporal and geographic shifts in fall and winter distributions were suspected during the 1980s when numbers of wintering Canada geese increased in Minnesota and declined in Missouri. However, concurrent increases in numbers of Mississippi Valley Population (MVP; B. c. interior) and Mississippi Flyway Giant Population (MFGP; B. c. maxima) Canada geese in portions of the winter range shared with EPP geese confounded interpretations of winter population and harvest surveys. During 1984‐93, researchers conducted a cooperative banding and observation effort to improve information on survival rates, harvest rates, and winter distributions of EPP Canada geese. Consistent harvest regulations within 3‐year periods during 1984‐93, combined with extensive observations of marked geese, allowed for an integrative analysis of survival and movements of this population relative to changes in harvest pressure. We used observations, recaptures, and hunter recoveries of marked geese to provide information on survival, harvest, and movements of the EPP that is needed for long‐term management of this population. Annual survival rates of neck‐banded adult geese averaged (x ± SE) 0.707 ± 0.019 during 1984‐86, 0.651 ± 0.022 during 1987‐89 when harvest seasons were restricted, and 0.595 ± 0.028 during 1990‐93 when harvest seasons were liberalized. Annual survival rates for neck‐banded adults were lower versus leg‐banded adults during 1987‐89 and 1990‐93 (P≤ 0.05). Mean survival of neck‐banded adults during the harvest seasons in 1987‐89 was lower than the mean rate in the harvest seasons of 1984‐86, primarily due to a low survival estimate in 1989. Survival averaged 0.918 ± 0.0129 during the 1987 and 1988 harvest seasons but declined to 0.665 ± 0.051 during 1989. Restrictions in harvest correlated with a decrease in direct recovery rates and an increase in survival rates of neck‐banded adults during the 1987 and 1988 harvest seasons, but not in 1989. Higher recovery rates in 1989‐92 suggested that increased harvest mortality contributed to lower survival of adult geese. However, mortality rates during the 1989‐92 harvest seasons increased at a greater proportion than increases in direct recovery rates, suggesting that factors other than harvest could have significantly impacted fall mortality rates of adult geese. Estimated within‐year probabilities of movement, along with population size estimates, suggested there was a northern shift in fall distributions of EPP Canada geese and delayed migrations during the late 1980s. Probabilities of southward movement for geese in the northern regions of the Flyway declined significantly during October and November when season lengths and quotas were reduced during 1987‐89. While restrictions in harvest in 1987‐89 corresponded with delays in fall movements, subsequent increases in harvest pressure in 1990‐92 did not promote southward movement of geese in early fall. Geese that survived the harvest season in 1990‐92 had lower rates of movement during October and early November than did geese that survived the harvest seasons in 1985‐86. The gradual shift in the estimated timing of north‐south movement, for birds known to have survived the harvest season, suggests mortality rates were higher for geese that moved south early in the fall in 1990‐92. However, the lack of information on reporting rates and crippling loss for Canada geese prevented direct estimation of the proportion of fall mortality attributable to harvest. Our study demonstrated that a variety of factors can interact to affect the distribution of Canada geese and complicate approaches to population management. Information from marked geese is a critical tool for monitoring changes in survival and harvest rates of Canada goose populations, especially in light of recent changes in winter distributions and resultant mixing of populations. Data for EPP Canada geese indicated that neck‐banded geese had lower survival and higher recovery rates than did leg‐banded geese. If harvest was the major source of mortality for EPP geese, our results suggested that actual reporting rates for Canada geese were lower than rates estimated for mallards (Anas platyrhynchos). In contrast, if harvest was not the major source of mortality for geese, then managers need to consider nonharvest mortality rates when determining optimal harvest rates for sustainable populations of Canada geese. In light of recent changes in band inscriptions designed to increase reporting rates, we recommend that managers limit the use of neck bands and that monitoring programs for Canada geese be designed to minimize potential biases due to colored auxiliary markers and differential reporting rates. We also recommend that band reporting rates be evaluated for goose populations across North America. Information on temporal and spatial differences in reporting rates would improve management efforts for EPP Canada geese by allowing a better understanding of the relative impacts of harvest and nonharvest mortality rates.
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- 2004
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100. A One-year, Randomised, Multicentre Trial Comparing Insulin Glargine with NPH Insulin in Combination with Oral Agents in Patients with Type 2 Diabetes
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Massi Benedetti, M., Humburg, E., Dressler, A., and Ziemen, M.
- Published
- 2003
- Full Text
- View/download PDF
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