Author: "Hiroshi Takeda" - Searchworks@Jio Institute Digital Library Search Results

1,602 results on '"Hiroshi Takeda"'

51. Capillary responses to functional and pathological activations rely on the capillary states at rest

Author: Hiroki Suzuki, Hiroshi Takeda, Hiroyuki Takuwa, Bin Ji, Makoto Higuchi, Iwao Kanno, and Kazuto Masamoto
Subjects: Neurology, Neurology (clinical), Cardiology and Cardiovascular Medicine
Abstract: Brain capillaries play a crucial role in maintaining cellular viability and thus preventing neurodegeneration. The aim of this study was to characterize the brain capillary morphology at rest and during neural activation based on a big data analysis from three-dimensional microangiography. Neurovascular responses were measured using a genetic calcium sensor expressed in neurons and microangiography with two-photon microscopy, while neural acivity was modulated by stimulation of contralateral whiskers or by a seizure evoked by kainic acid. For whisker stimulation, 84% of the capillary sites showed no detectable diameter change. The remaining 10% and 6% were dilated and constricted, respectively. Significant differences were observed for capillaries in the diameter at rest between the locations of dilation and constriction. Even the seizures resulted in 44% of the capillaries having no detectable change in diameter, while 56% of the capillaries dilated. The extent of dilation was dependent on the diameter at rest. In conclusion, big data analysis on brain capillary morphology has identified at least two types of capillary states: capillaries with diameters that are relatively large at rest and stable over time regardless of neural activity and capillaries whose diameters are relatively small at rest and vary according to neural activity.
Published: 2023

52. Correlation between the reduction in hippocampal SirT2 expression and depressive-like behaviors and neurological abnormalities in olfactory bulbectomized mice

Author: Kohei, Takahashi, Kazuhiro, Kurokawa, Lihua, Hong, Kazuya, Miyagawa, Atsumi, Mochida-Saito, Hiroshi, Takeda, and Minoru, Tsuji
Subjects: Disease Models, Animal, Mice, Neuronal Plasticity, Sirtuin 2, Depression, General Neuroscience, Animals, General Medicine, Hippocampus, Olfactory Bulb
Abstract: Reduced activity of hippocampal silent information regulator protein 2 (SirT2) has been associated with the development of depression caused by disturbances in neuronal and synaptic plasticity. However, changes in the hippocampal SirTs in olfactory bulbectomized (OBX) mice, an animal model of depression, remain unknown. Therefore, this study examined depressive-like behaviors, hippocampal SirTs, synaptic plasticity-associated proteins, and cell proliferation in OBX mice. The OBX mice showed depressive-like behaviors; reduced SirT2, synaptophysin, and PSD95 levels; and reduced cell proliferation in the hippocampus. These data indicate that decreased hippocampal SirT2 may contribute to pathophysiological depression and strongly affect the psychological state.
Published: 2022

53. Tag-based Video Retrieval with Social Tag Relevance Learning.

Author: Hiroshi Takeda, Soh Yoshida, and Mitsuji Muneyasu
Published: 2019
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54. Large time behavior of solutions to elastic wave with structural damping

Author: Hiroshi Takeda
Subjects: Applied Mathematics, Analysis
Published: 2022

55. Role of Mitochondrial Dysfunction in the Pathogenesis of Cisplatin-Induced Myotube Atrophy

Author: Chinami, Matsumoto, Hitomi, Sekine, Miwa, Nahata, Sachiko, Mogami, Katsuya, Ohbuchi, Naoki, Fujitsuka, and Hiroshi, Takeda
Subjects: Pharmacology, Myosin Heavy Chains, Ubiquitin, Muscle Fibers, Skeletal, Pharmaceutical Science, General Medicine, Mitochondria, Muscular Atrophy, Adenosine Triphosphate, Quality of Life, Humans, Cisplatin, Muscle, Skeletal, Reactive Oxygen Species
Abstract: Muscle atrophy is commonly observed during cisplatin chemotherapy, leading to a reduced QOL in cancer patients. Reduced skeletal muscle mass caused by cisplatin treatment results from the activation of ubiquitin ligases-Atrogin-1 and MuRF1, but the precise mechanisms are poorly understood. In this study, we investigated the possible involvement of mitochondrial dysfunction, including reactive oxygen species (ROS) generation and ATP production, in cisplatin-induced muscle atrophy. Skeletal C2C12 myotubes were treated with cisplatin, and gene and protein expression were evaluated. Mitochondrial mass, membrane potential, and ROS levels were measured using fluorescent dyes. Mitochondrial respiratory function, ATP production rates, and glycolytic capacity were also analyzed using an extracellular flux analyzer. Metabolomic analyses were performed using gas chromatography-tandem mass spectrometry. Cisplatin treatment reduced myosin heavy chain expression by activating the ubiquitin-proteasome system. Increased ROS production was observed after cisplatin treatment, followed by significant changes in apoptosis-related gene expression and decrease in mitochondrial mass, membrane potential, respiration, and ATP production. Glycolytic capacity and tricarboxylic acid (TCA) cycle metabolite levels were reduced with cisplatin treatment. Mitochondria-targeted antioxidant mitoquinone mesylate prevented up-regulation of Atrogin-1 gene expression and restored myosin heavy chain levels, accompanied by a decrease in ROS generation, but not mitochondrial ATP production. We concluded that cisplatin-induced myotube atrophy was associated with mitochondrial dysfunction. Reducing ROS generation, rather than promoting ATP production, could be a useful therapeutic strategy for preventing cisplatin-induced muscle atrophy.
Published: 2022

56. GARFIELD-AF: risk profiles, treatment patterns and 2-year outcomes in patients with atrial fibrillation in Germany, Austria and Switzerland (DACH) compared to 32 countries in other regions worldwide

Author: Sylvia, H, John A, C, Darius, H, Jan, S, Saverio, V, Karen, P, Marianne, B, Sebastian, S, Frank, M, Gloria, K, Kakkar, A, Bassand, J, John Camm, A, Fitzmaurice, D, Fox, K, Gersh, B, Goldhaber, S, Goto, S, Haas, S, Hacke, W, Mantovani, L, Misselwitz, F, Pieper, K, Turpie, A, van Eickels, M, Verheugt, F, Gersh, K, Lucas Luciardi Harry Gibbs, H, Brodmann, M, Cools, F, Carlos Pereira Barretto, A, Connolly, S, Eikelboom, J, Corbalan, R, Jing, Z, Jansky, P, Dalsgaard Nielsen, J, Ragy, H, Raatikainen, P, Le Heuzey, J, Keltai, M, Pal Singh Sawhney, J, Agnelli, G, Ambrosio, G, Koretsune, Y, Jerjes Sánchez Díaz, C, Ten Cate, H, Atar, D, Stepinska, J, Panchenko, E, Wei Lim, T, Jacobson, B, Oh, S, Viñolas, X, Rosenqvist, M, Steffel, J, Angchaisuksiri, P, Oto, A, Parkhomenko, A, Al Mahmeed, W, Hu Kangning Chen, D, Zhao, Y, Zhang, H, Chen, J, Cao, S, Wang, D, Yang, Y, Li, W, Li, H, Yin, Y, Tao, G, Yang, P, Chen, Y, He, S, Wang, Y, Fu, G, Li, X, Wu, T, Cheng, X, Yan, X, Zhao, R, Chen, M, Xiong, L, Chen, P, Jiao, Y, Guo, Y, Xue, L, Yang, Z, Jadhavm Raghava Sarma, P, Kulkarni, G, Chandwani, P, Atulbhai Pothiwala, R, Padinhare Purayil, M, Chawla, K, Annasaheb Kothiwale, V, Raghuraman, B, Madan Vijan, V, Sawhney, J, Bantwal, G, Khan, A, Meena, R, Chopada, M, Abraham, S, Bisne, V, Vijayaraghavan, G, Roy, D, Durgaprasad, R, Ravi Shankar, A, Kumar, S, Jain, D, Bhargava, K, Kumar, V, Madappa Nagamalesh, U, Kumar Rajput, R, Koretsune Seishu Kanamori, Y, Yamamoto, K, Kumagai, K, Katsuda, Y, Yoshida, K, Toyota, F, Mizuno, Y, Misumi, I, Noguchi, H, Ando, S, Suetsugu, T, Minamoto, M, Oda, H, Adachi, S, Chiba, K, Norita, H, Tsuruta, M, Koyanagi, T, Ando, H, Higashi, T, Okada, M, Azakami, S, Komaki, S, Kumeda, K, Murayama, T, Matsumura, J, Oba, Y, Sonoda, R, Goto, K, Minoda, K, Haraguchi, Y, Suefuji, H, Miyagi, H, Kato, H, Nakamura, T, Nandate, H, Zaitsu, R, Fujiura, Y, Yoshimura, A, Numata, H, Ogawa, J, Kamogawa, Y, Murakami, K, Wakasa, Y, Yamasawa, M, Maekawa, H, Abe, S, Kihara, H, Tsunoda, S, Saito, K, Tachibana, H, Oba, I, Kuwahata, T, Higa, S, Gushiken, M, Eto, T, Chibana, H, Fujisawa, K, Shiga, Y, Sumi, H, Nagatomo, T, Atsuchi, Y, Nagoshi, T, Sanno, K, Hoshino, F, Yokota, N, Kameko, M, Tabuchi, T, Ishizawa, M, Ikeda, D, Seto, T, Iwao, T, Ishioka, N, Oshiro, K, Tsuchida, K, Hatori, Y, Takeuchi, M, Takezawa, H, Nagano, S, Iwaki, M, Nakamura, Y, Miyamoto, N, Taguchi, T, Ashida, K, Yoshizawa, N, Agata, J, Matsukawa, S, Arasaki, O, Fukuoka, S, Murakami, H, Mishima, K, Hata, Y, Sakuma, I, Obunai, K, Takamura, I, Akutsu, M, Unoki, T, Go, Y, Ikemura, M, Morii, S, Marusaki, S, Doi, H, Tanaka, M, Kusumoto, T, Kakinoki, S, Ogurusu, C, Murata, K, Shimoyama, M, Nakatsuka, M, Kitami, Y, Oyama, R, Ageta, M, Mita, T, Nagao, K, Mito, T, Minami, J, Abe, M, Fujii, M, Okawa, M, Fujito, T, Taniguchi, T, Ko, T, Kubo, H, Imamaki, M, Akiyama, M, Ueda, T, Odakura, H, Inagaki, M, Katsube, Y, Nakata, A, Tomimoto, S, Shibuya, M, Nakano, M, Ito, K, Matsuta, M, Ishiguro, M, Minagawa, T, Wada, M, Mukawa, H, Mizuguchi, M, Okuda, F, Kimura, T, Taga, K, Techigawara, M, Igarashi, M, Watanabe, H, Seo, T, Hiramitsu, S, Hosokawa, H, Hoshiai, M, Hibino, M, Miyagawa, K, Horie, H, Sugishita, N, Soma, A, Neya, K, Yoshida, T, Akahane, K, Takanaka, C, Matsui, S, Kanda, H, Kaneko, M, Nagasaka, S, Taguchi, A, Toru, S, Miyashita, A, Sasaguri, H, Nariyama, J, Hatsuno, T, Iwase, T, Sato, K, Kawai, K, Kotani, T, Tsuji, T, Sakai, H, Nishino, K, Ikeda, K, Maeda, K, Shinozuka, T, Inoue, T, Kawakami, K, Kitazumi, H, Takagi, T, Hamaoka, M, Kojima, J, Sasaki, A, Tsuchiya, Y, Betsuyaku, T, Higuchi, K, Honda, M, Hasegawa, K, Baba, T, Mineoi, K, Koeda, T, Hirasawa, K, Kumazaki, T, Nakagomi, A, Otaki, E, Shindo, T, Hirayama, H, Sugimoto, C, Yamagishi, T, Mizuguchi, I, Sezaki, K, Niwa, I, Takenaka, K, Iiji, O, Taya, K, Kitazawa, H, Ueda, S, Kakuda, H, Ono, T, Oriso, S, Kamata, J, Nanke, T, Maeda, I, Matsuura, Y, Teragawa, H, Maruyama, Y, Takei, K, Kito, T, Asano, H, Matsushita, K, Nakamura, M, Washizuka, T, Sawano, M, Arima, S, Arai, H, Shinohara, H, Takai, H, Furukawa, N, Ota, A, Aoki, K, Yamamoto, T, Kasai, T, Suzuki, S, Shibata, N, Watanabe, M, Nishihata, Y, Arino, T, Okuyama, M, Wakiyama, T, Kato, T, Sasagawa, Y, Tana, T, Hayashi, Y, Hirota, S, Abe, Y, Saito, Y, Uchiyama, H, Takeda, H, Ono, H, Tohyo, S, Hanazono, N, Miyajima, S, Shimono, H, Aoyama, T, Shozawa, Y, Niijima, Y, Murai, O, Inaba, H, Nomura, K, Nozoe, M, Suzuki, K, Furukawa, T, Shiraiwa, T, Ito, N, Nagai, S, Nakahara, S, Shimoyama, Y, Ohara, N, Kozuka, T, Okita, H, Endo, M, Goto, T, Hirose, M, Nagata, E, Nakanishi, N, Mori, T, Seki, S, Okamoto, K, Moriai, O, Emura, Y, Fukuda, T, Date, H, Kawakami, S, Ueyama, Y, Fudo, T, Imaizumi, M, Ogawa, T, Take, S, Ikeda, H, Nishioka, H, Sakamoto, N, Ikeoka, K, Wakaki, N, Doiuchi, J, Kira, T, Tada, M, Tsuzaki, K, Miura, N, Fujisawa, Y, Furumoto, W, Fujisawa, A, Nakamura, R, Komatsu, H, Fujiki, R, Kawano, S, Nishizawa, K, Kato, Y, Azuma, J, Yasui, K, Amano, T, Sekine, Y, Honzawa, T, Koshibu, Y, Sakamoto, Y, Seta, Y, Miyaguchi, S, Morishita, K, Samejima, Y, Sasaki, T, Iseki, F, Kobayashi, T, Kano, H, Kim, J, Yamaguchi, H, Takagi, Y, Onuki Pearce, Y, Suzuki, Y, Fukui, T, Nakayama, T, Kanai, H, Kawano, Y, Ino, T, Miyoshi, H, Miyamoto, Y, Shigekiyo, M, Ono, S, Okamoto, Y, Ubukata, S, Kodera, K, Oriuchi, T, Matsumoto, N, Inagaki, K, Iseki, A, Goda, T, Katsuki, T, Sato, A, Mori, E, Tsubokura, T, Shudo, H, Fujimoto, S, Katsuya, T, Furukawa, Y, Narumi, J, Owari, M, Inakura, T, Anno, T, Shirakawa, K, Keong Ching Toon Wei Lim, C, Foo, D, Wong, K, Yuyang, T, Oh Hui Nam Park, S, Kim, W, Lee, H, Jang, S, Hyeok Kim, D, Ryu, D, Shim, J, Kim, D, Ju Choi, D, Seog Oh, Y, Cho, M, Kim, H, Jeon, H, Shin, D, Weon Park, S, Ki Park, H, Han, S, Hoon Sung, J, Park, H, Nam, G, Keun On, Y, Euy Lim, H, Kwak, J, Cha, T, Jong Hong, T, Hoon Park, S, Han Yoon, J, Kim, N, Kim, K, Chun Jung, B, Hwang, G, Kim, C, Rungaramsin Peerapat Katekangplu, S, Khunrong, P, Bunyapipat, T, Wongcharoen, W, Kaewsuwanna, P, Siriwattana, K, Tiyanon, W, Pattanaprichakul, S, Likittanasombat, K, Cholsaringkarl, D, Boonyapisit, W, Cheewatanakornkul, S, Silaruks, S, Hutayanon, P, Chawanadelert, S, Chattranukulchai, P, Chatlaong, B, Santanakorn, Y, Kanokphatcharakun, K, Mongkolwongroj, P, Jai-Aue, S, Komson, O, Altun Ali Aydinlar, A, Topsakal, R, Ongen, Z, Acikel, S, Yildiray Sahin, D, Yilmaz, O, Birhan Yilmaz, M, Pekdemir, H, Demir, M, Sucu, M, Sahiner, L, Ersanli, M, Okuyan, E, Aras, D, Rolandi Adrian Cesar Ingaramo, F, Alberto Sambadaro, G, Fernandez Caputi, V, Luciardi, H, Graciela Berman, S, Dragotto, P, Javier Kleiban, A, Centurion, N, Andres Ahuad Guerrero, R, Adalberto Di Paola, L, Dario Dran, R, Egido, J, Jose Fosco, M, Alfredo Sinisi, V, Rodolfo Cartasegna, L, Gomez Vilamajo, O, Luis Ramos, J, Sassone, S, Zapata, G, Conde, D, Giacomi, G, Alfredo Fernandez, A, Alberto Berli, M, Ferroni, F, Celestino Sobral Filho Jefferson Jaber, D, Vidal Armaganijan, L, Roberto Frack Costantini, C, Steffens, A, Kunz Sebba Barroso de Souzaem, W, David de Souza Neto, J, Márcio Ribeiro, J, Silveira Teixeira, M, Rossi, P, Pires, L, Moreira, D, Carlos Moura Jorge, J, Menezes Lorga Filho, A, Bodanese, L, Westerlund Montera, M, Henrique Del Carlo, C, Abdalla Saad, J, Augusto Alves da Costa, F, Lopes, R, Roberto de Araújo, G, Roberto Manenti, E, Francisco Kerr Saraiva, J, Carlos Ferreira Braga, J, Negri, A, Moncada, C, Precoma, D, Roquette, F, Reis, G, Álvaro Ramos Filho, R, Lanna Figueiredo, E, Vieira Botelho, R, Munhoz da Fontoura Tavares, C, Carlos Finimundi, H, Kochi, A, Cássio Broilo França, C, Alban, F, Bernardo Aranha Rosito, G, Batista de Moura Xavier Moraes Junior, J, Tadeu Tumelero, R, Maia, L, Simões de Almeida, R, Carter do Carmo Borges, N, Gustavo Gomes Ferreira, L, Corbalán Benjamin Aleck Joseh Stockins Fernandez, R, Montecinos, H, Lanas, F, Larico Gómez, M, Astudillo, C, Conejeros, C, Marin Cuevas, P, Forero, A, Bugueño Gutiérrez, C, Aguilar, J, Potthoff Cardenas, S, Eggers, G, Houzvic, C, Rey, C, Arriagada, G, Charme Vilches, G, Jerjes Sanchez Diaz Jesus Jaime Illescas Diaz, C, Leal Cantu, R, Guadalupe Ramos Zavala, M, Cabrera Jardines, R, Espinola Zavaleta, N, Lopez Rosas, E, Antonio Llamas Esperón, G, Pozas, G, Cardona Muñoz, E, Matadamas Hernandez, N, Leyva Rendon, A, Garcia Hernandez, N, de los Rios Ibarra, M, Ramon Virgen Carrillo, L, Lopez Villezca, D, Hernandez Herrera, C, Jose Lopez Prieto, J, Gaona Rodriguez, R, Villeda Espinosa, E, Flores Martinez, D, Velasco Barcena, J, Fierro Fierro, O, Rodriguez Briones, I, Luis Leiva Pons, J, Alvarez Lopez, H, Olvera Ruiz, R, Gerardo Cantu Brito, C, Julian Jose Roberto Chuquiure Valenzuela, E, Reyes Sanchez, R, Esteban Bazzoni Ruiz, A, Martin Lopez Ruiz, O, Arriaga Nava, R, David Morales Cerda, J, Fajardo Campos, P, Benavides Gonzalez, M, Brodmann Kurt Lenz, M, Hagn, C, Foechterle, J, Drexel, H, Huber, K, Podczeck-Schweighofer, A, Winkler, M, Schneeweiss, B, Gegenhuber, A, Lang, W, Eichinger-Hasenauer, S, Kaserer, P, Sykora, J, Rasch, H, Strohmer, B, Capiau Geert Vervoort, L, Wollaert, B, Hollanders, G, Vercammen, J, Faes, D, Balthazar, Y, Delforge, M, Xhaet, O, Striekwold, H, Thoeng, J, Hermans, K, Mairesse, G, Anné, W, Blankoff, I, Beutels, M, Verstraete, S, Vandergoten, P, Purnode, P, Godart, P, Boussy, T, Desfontaines, P, Heyse, A, Voet, J, De Wolf, A, Zidkova Petr Jansky, E, Spacek, R, Machova, V, Ludka, O, Olsr, J, Kotik, L, Racz, B, Ferkl, R, Hubac, J, Kotik, I, Monhart, Z, Burianova, H, Jerabek, O, Pisova, J, Petrova, I, Dedek, V, Honkova, M, Podrazil, P, Reichert, P, Spinar, J, Novak, M, Durdil, V, Plocova, K, Lastuvka, J, Nielsen Steen Husted, J, Dominguez, H, Hintze, U, Rasmussen, S, Sygehus, N, Bremmelgaard, A, Markenvard, J, Børger, J, Solgaard, J, Eriksen, E, Løkkegaard, T, Bruun, M, Mertz, J, Schou, M, Olsen, M, Raatikainen Carmela Viitanen, P, Paganelli Joël Ohayon, F, Casassus, F, Galinier, M, Gottwalles, Y, Loiselet, P, Muller, J, Bassel Koujan, M, Marquand, A, Destrac, S, Piot, O, Delarche, N, Cebron, J, Guenoun, M, Guedj-Meynier, D, Lokesh, A, Zuber, M, Amarenco, P, Ellie, E, Kadouch, J, Fournier, P, Huberman, J, Lemaire, N, Rodier, G, Vandamme, X, Sibon, I, Neau, J, Hélène Mahagne, M, Mielot, A, Bonnefoy, M, Churet, J, Navarre, V, Sellem, F, Monniot, G, Boyes, J, Doucet, B, Martelet, M, Obadia, D, Crousillat, B, Mouallem, J, Bearez, E, Philippe Brugnaux, J, Fedorowsky, A, Nazeyrollas, P, Berneau, J, Chemin, F, Schellong Harald Darius, S, Koeniger, G, Kopf, A, Gerbaulet, U, Kellner, B, Schaefer, T, Purr, J, Eißfeller, E, Zauzig, H, Riegel, P, Axthelm, C, Heinz, G, Menke, H, Pustelnik, A, Zutz, S, Eder, W, Rehling, G, Glatzel, D, Ludwig, N, Sandow, P, Wiswedel, H, Wildenauer, C, Schoen, S, Schwarz, T, Babyesiza, A, Kropp, M, Zimny, H, Kahl, F, Caspar, A, Omankowsky, S, Laessig, T, Hartmann, H, Lehmann, G, Bindig, H, Hergdt, G, Reimer, D, Hauk, J, Michel, H, Werner Erdle, P, Dorsch, W, Dshabrailov, J, Rapp, K, Vormann, R, Mueller, T, Mayer, P, Horstmeier, U, Eissing, V, Hey, H, Leuchtgens, H, Lilienweiss, V, Mueller, H, Schubert, C, Lauer, H, Buchner, T, Brauer, G, Kamin, S, Mueller, K, Baumbach, S, Abdel-Qader, M, Ebert, H, Schwencke, C, Bernhardt, P, Karolyi, L, Sievers, B, Haverkamp, W, Roehnisch, J, Vertes Gabor Szantai, A, Matoltsy, A, Kanakaridisz, N, Boda, Z, Kis, E, Gaszner, B, Juhasz, F, Juhasz, G, Kancz, S, Laszlo, Z, May, Z, Merkely, B, Noori, E, Habon, T, Polgar, P, Szalai, G, Vangel, S, Nagy, A, Engelthaler, G, Ferenczi, J, Egyutt, M, Martini Leone Maria Cristina, G, Tiraferri, E, Santoro, R, Testa, S, Di Minno, G, Moia, M, Maria Caimi, T, Tessitori, M, Cappelli, R, Poli, D, Quintavalla, R, Cosmi, F, Fanelli, R, Oriana, V, Reggio, R, Santi, R, Pancaldi, L, De Cristofaro, R, Guazzaloca, G, De Blasio, A, Salerno Uriate, J, Lillo, F, Maria Pogliani, E, Bilo, G, Accogli, M, Mariani, A, Feola, M, Raisaro, A, Fattore, L, Mauric, A, Germini, F, Tedeschi, L, Settimi, M, Nicoli, S, Ricciarini, P, Argena, A, Ronchini, P, Bulla, C, Tradati, F, Volpe, M, D’Avino, M, Grazia Bongiorni, M, Severi, S, Capucci, A, Lodigiani, C, Salomone, E, Serviddio, G, Tondo, C, Golino, P, Mazzone, C, Iacopino, S, Ruiter, H, Lucassen, A, Adriaansen, H, Bongaerts, M, Pieterse, M, van Guldener, C, Herrman, J, Nierop, S, Hoogslag, P, Hermans, W, Groenemeijer, B, Terpstra, W, Buiks, C, Boersma, L, Berge Per Anton Sirnes, E, Gjertsen, E, Hole, T, Erga, K, Hallaråker, A, Skjelvan, G, Østrem, A, Ghezai, B, Svilaas, A, Christersson, P, Øien, T, Høegh Henrichsen, S, Erik Otterstad, J, Berg-Johansen, J, Stepinska Andrzej Gieroba, J, Biedrzycka, M, Ogorek, M, Wozakowska-Kaplon, B, Loboz-Grudzien, K, Jaroslaw, Supinski, W, Kuzniar, J, Zaluska, R, Hiczkiewicz, J, Swiatkowska-Byczynska, L, Kucharski, L, Gruchala, M, Minc, P, Olszewski, M, Kania, G, Krzciuk, M, Lajkowski, Z, Ostrowska-Pomian, B, Lewczuk, J, Zinka, E, Karczmarczyk, A, Chmielnicka-Pruszczynska, M, Wozniak-Skowerska, I, Opolski, G, 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Rikimaru Oyama, Masato Ageta, Teruaki Mita, Kazuhiko Nagao, Takafumi Mito, Junichi Minami, Mitsunori Abe, Masako Fujii, Makoto Okawa, Tsuneo Fujito, Toshiya Taniguchi, Tenei Ko, Hiroshi Kubo, Mizuho Imamaki, Masahiro Akiyama, Takashi Ueda, Hironori Odakura, Masahiko Inagaki, Yoshiki Katsube, Atsuyuki Nakata, Shinobu Tomimoto, Mitsuhiro Shibuya, Masayuki Nakano, Kenichiro Ito, Masahiro Matsuta, Motoyuki Ishiguro, Taro Minagawa, Masamichi Wada, Hiroaki Mukawa, Masato Mizuguchi, Fumio Okuda, Teruaki Kimura, Kuniaki Taga, Masaaki Techigawara, Morio Igarashi, Hiroshi Watanabe, Toshihiko Seo, Shinya Hiramitsu, Hiroaki Hosokawa, Mitsumoto Hoshiai, Michitaka Hibino, Koichi Miyagawa, Hideki Horie, Nobuyoshi Sugishita, Yukio Shiga, Akira Soma, Kazuo Neya, Tetsuro Yoshida, Kunio Akahane, Sen Adachi, Chiei Takanaka, Saori Matsui, Hirofumi Kanda, Masanori Kaneko, Shiro Nagasaka, Atsushi Taguchi, Shuta Toru, Kazuyuki Saito, Akiko Miyashita, Hiroki Sasaguri, Jin Nariyama, Taketo Hatsuno, Takash Iwase, Kazuki Sato, Kazuya Kawai, Tomobumi Kotani, Tsuyoshi Tsuji, Hirosumi Sakai, Kiyoshi Nishino, Kenichi Ikeda, Kazuo Maeda, Tomohiro Shinozuka, Takeshi Inoue, Koichi Kawakami, Hiromichi Kitazumi, Tsutomu Takagi, Mamoru Hamaoka, Jisho Kojima, Akitoshi Sasaki, Yoshihiro Tsuchiya, Tetsuo Betsuyaku, Koji Higuchi, Masaaki Honda, Koichi Hasegawa, Takao Baba, Kazuaki Mineoi, Toshihiko Koeda, Kunihiko Hirasawa, Toshihide Kumazaki, Akira Nakagomi, Eiji Otaki, Takashi Shindo, Hiroyoshi Hirayama, Chikako Sugimoto, Takashi Yamagishi, Ichiro Mizuguchi, Kazunori Sezaki, Isamu Niwa, Ken Takenaka, Osamu Iiji, Koichi Taya, Hitoshi Kitazawa, samu Ueda, Hirokazu Kakuda, Takuya Ono, Seizo Oriso, Junya Kamata, Toshihiko Nanke, Itaru Maeda, Yoshifusa Matsuura, Hiroki Teragawa, Yasuyuki Maruyama, Kazuo Takei, Hajime Horie, Tetsutaro Kito, Hiroshi Asano, Koji Matsushita, Masaichi Nakamura, Takashi Washizuka, Tomoki Yoshida, Masato Sawano, Shinichi Arima, Hidekazu Arai, Hisanori Shinohara, Hiroyuki Takai, Nobufusa Furukawa, Akira Ota, Kentaro Yamamoto, Kenji Aoki, Taku Yamamoto, Takeaki Kasai, Shunji Suzuki, Shu Suzuki, Nitaro Shibata, Masayuki Watanabe, Yosuke Nishihata, Toru Arino, Masaki Okuyama, Tetsushi Wakiyama, Tomoko Kato, Yasuo Sasagawa, Takeshi Tana, Yoshihito Hayashi, Shinichi Hirota, Yukihiko Abe, Yoshihiro Saito, Hirohide Uchiyama, Hiroshi Takeda, Hiroshi Ono, Shuichi Tohyo, Naoto Hanazono, Seiichi Miyajima, Hisashi Shimono, Takuma Aoyama, Yasunobu Shozawa, Yawara Niijima, Osamu Murai, Hideko Inaba, Katsumasa Nomura, Masatsugu Nozoe, Kazuo Suzuki, Toshiyuki Furukawa, Toshihiko Shiraiwa, Nobuhisa Ito, Shunichi Nagai, Kiyoharu Sato, Shiro Nakahara, Yujin Shimoyama, Naoko Ohara, Teruhiko Kozuka, Hideaki Okita, Masato Endo, Tsutomu Goto, Makoto Hirose, Emiko Nagata, Noriyuki Nakanishi, Toshizumi Mori, Shuichi Seki, Katsuhiro Okamoto, Osamu Moriai, Yoko Emura, Tsuyoshi Fukuda, Haruhiko Date, Shuichi Kawakami, Sho Nagai, Yuya Ueyama, Tetsuro Fudo, Mitsuru Imaizumi, Takuo Ogawa, Shunsuke Take, Hideo Ikeda, Hiroaki Nishioka, Norihiko Sakamoto, Kiyomitsu Ikeoka, Nobuo Wakaki, Masatake Abe, Junji Doiuchi, Tetsuya Kira, Masato Tada, Ken Tsuzaki, Naoya Miura, Yasuaki Fujisawa, Wataru Furumoto, Susumu Suzuki, Akinori Fujisawa, Ryosai Nakamura, Hiroyasu Komatsu, Rei Fujiki, Shuichi Kawano, Keijiro Nishizawa, Yoji Kato, Junya Azuma, Kiyoshi Yasui, Toshio Amano, Yasuhiro Sekine, Tatsuo Honzawa, Yuichiro Koshibu, Yasuhide Sakamoto, Yukihiro Seta, Shingo Miyaguchi, Kojuro Morishita, Yasuko Samejima, Toyoshi Sasaki, Fumiko Iseki, Toshiyuki Kobayashi, Hiroshi Kano, Jaeyoung Kim, Hiroshi Yamaguchi, Yoichi Takagi, Yoko Onuki Pearce, Yasuyuki Suzuki, Takayuki Fukui, Toru Nakayama, Hideaki Kanai, Yoshiyuki Kawano, Tetsuji Ino, Hironori Miyoshi, Yasufumi Miyamoto, Masahito Shigekiyo, Shimato Ono, Yutaka Okamoto, Satoshi Ubukata, Kojiro Kodera, Tatsuo Oriuchi, Naoki Matsumoto, Koichi Inagaki, Atsushi Iseki, Tomohiro Yoshida, Toshihiro Goda, Tsukasa Katsuki, Atsushi Sato, Etsuo Mori, Toshio Tsubokura, Hiroshi Shudo, Shunichi Fujimoto, Tomohiro Katsuya, Yoshiyuki Furukawa, Hiroshi Hosokawa, Jun Narumi, Kiichiro Yamamoto, Masaki Owari, Takuya Inakura, Takafumi Anno, Kazuyuki Shirakawa, Chi Keong Ching Toon Wei Lim, David Foo, Kelvin Wong, Tan Yuyang, Seil Oh Hui Nam Park, Woo-Shik Kim, HyeYoung Lee, Sung-Won Jang, Dae Hyeok Kim, Jun Kim, DongRyeol Ryu, Jaemin Shim, Dae-Kyeong Kim, Dong Ju Choi, Yong Seog Oh, Myeong-Chan Cho, Hack-Lyoung Kim, Hui-Kyung Jeon, Dong-Gu Shin, Sang Weon Park, Hoon Ki Park, Sang-Jin Han, Jung Hoon Sung, Hyung-Wook Park, Gi-Byoung Nam, Young Keun On, Hong Euy Lim, JaeJin Kwak, Tae-Joon Cha, Taek Jong Hong, Seong Hoon Park, Jung Han Yoon, Nam-Ho Kim, Kee-Sik Kim, Byung Chun Jung, Gyo-Seung Hwang, Chong-Jin Kim, Sakda Rungaramsin Peerapat Katekangplu, Porames Khunrong, Thanita Bunyapipat, Wanwarang Wongcharoen, Pinij Kaewsuwanna, Khanchai Siriwattana, Waraporn Tiyanon, Supalerk Pattanaprichakul, Khanchit Likittanasombat, Doungrat Cholsaringkarl, Warangkana Boonyapisit, Sirichai Cheewatanakornkul, Songkwan Silaruks, Pisit Hutayanon, Seksan Chawanadelert, Pairoj Chattranukulchai, Boonsert Chatlaong, Yingsak Santanakorn, Khompiya Kanokphatcharakun, Piya Mongkolwongroj, Sasivimon Jai-Aue, Ongkarn Komson, Armagan Altun Ali Aydinlar, Ramazan Topsakal, Zeki Ongen, Sadik Acikel, Durmus Yildiray Sahin, Ozcan Yilmaz, Mehmet Birhan Yilmaz, Hasan Pekdemir, Mesut Demir, Murat Sucu, Levent Sahiner, Murat Ersanli, Ertugrul Okuyan, Dursun Aras, Florencia Rolandi Adrian Cesar Ingaramo, Gustavo Alberto Sambadaro, Vanina Fernandez Caputi, Hector Luciardi, Sofia Graciela Berman, Pablo Dragotto, Andres Javier Kleiban, Nestor Centurion, Rodolfo Andres Ahuad Guerrero, Leonel Adalberto Di Paola, Ricardo Dario Dran, Javier Egido, Matias Jose Fosco, Victor Alfredo Sinisi, Luis Rodolfo Cartasegna, Oscar Gomez Vilamajo, Jose Luis Ramos, Sonia Sassone, Gerardo Zapata, Diego Conde, Guillermo Giacomi, Alberto Alfredo Fernandez, Mario Alberto Berli, Fabian Ferroni, Dário Celestino Sobral Filho Jefferson Jaber, Luciana Vidal Armaganijan, Costantino Roberto Frack Costantini, André Steffens, Weimar Kunz Sebba Barroso de Souzaem, João David de Souza Neto, José Márcio Ribeiro, Marcelo Silveira Teixeira, Paulo Rossi, Leonardo Pires, Daniel Moreira, José Carlos Moura Jorge, Adalberto Menezes Lorga Filho, Luiz Bodanese, Marcelo Westerlund Montera, Carlos Henrique Del Carlo, Jamil Abdalla Saad, Fernando Augusto Alves da Costa, Renato Lopes, Gilson Roberto de Araújo, Euler Roberto Manenti, Jose Francisco Kerr Saraiva, João Carlos Ferreira Braga, Alexandre Negri, Carlos Moncada, Dalton Precoma, Fernando Roquette, Gilmar Reis, Roberto Álvaro Ramos Filho, Estêvão Lanna Figueiredo, Roberto Vieira Botelho, Cláudio Munhoz da Fontoura Tavares, Helius Carlos Finimundi, Adriano Kochi, César Cássio Broilo França, Fábio Alban, Guido Bernardo Aranha Rosito, João Batista de Moura Xavier Moraes Junior, Rogério Tadeu Tumelero, Lilia Maia, Roberto Simões de Almeida, Ney Carter do Carmo Borges, Luís Gustavo Gomes Ferreira, Ramón Corbalán Benjamin Aleck Joseh Stockins Fernandez, Humberto Montecinos, Fernando Lanas, Martín Larico Gómez, Carlos Astudillo, Carlos Conejeros, Patricio Marin Cuevas, Alejandro Forero, Claudio Bugueño Gutiérrez, Juan Aguilar, Sergio Potthoff Cardenas, German Eggers, Cesar Houzvic, Carlos Rey, Germán Arriagada, Gustavo Charme Vilches, Carlos Jerjes Sanchez Diaz Jesus Jaime Illescas Diaz, Raul Leal Cantu, Maria Guadalupe Ramos Zavala, Ricardo Cabrera Jardines, Nilda Espinola Zavaleta, Enrique Lopez Rosas, Guillermo Antonio Llamas Esperón, Gerardo Pozas, Ernesto Cardona Muñoz, Norberto Matadamas Hernandez, Adolfo Leyva Rendon, Norberto Garcia Hernandez, Manuel de los Rios Ibarra, Luis Ramon Virgen Carrillo, David Lopez Villezca, Carlos Hernandez Herrera, Juan Jose Lopez Prieto, Rodolfo Gaona Rodriguez, Efrain Villeda Espinosa, David Flores Martinez, Jose Velasco Barcena, Omar Fierro Fierro, Ignacio Rodriguez Briones, Jose Luis Leiva Pons, Humberto Alvarez Lopez, Rafael Olvera Ruiz, Carlos Gerardo Cantu Brito, Eduardo Julian Jose Roberto Chuquiure Valenzuela, Roxana Reyes Sanchez, Alberto Esteban Bazzoni Ruiz, Oscar Martin Lopez Ruiz, Roberto Arriaga Nava, Jesus David Morales Cerda, Pedro Fajardo Campos, Mario Benavides Gonzalez, Marianne Brodmann Kurt Lenz, Claus Hagn, Johannes Foechterle, Heinz Drexel, Kurt Huber, Andrea Podczeck-Schweighofer, Michael Winkler, Bruno Schneeweiss, Alfons Gegenhuber, Wilfried Lang, Sabine Eichinger-Hasenauer, Peter Kaserer, Josef Sykora, Heribert Rasch, Bernhard Strohmer, Luc Capiau Geert Vervoort, Bart Wollaert, Geert Hollanders, Jan Vercammen, Dirk Faes, Yohan Balthazar, Marc Delforge, Olivier Xhaet, Harry Striekwold, John Thoeng, Kurt Hermans, Georges Mairesse, Wim Anné, Ivan Blankoff, Michel Beutels, Stefan Verstraete, Peter Vandergoten, Philippe Purnode, Pascal Godart, Tim Boussy, Philippe Desfontaines, Alex Heyse, Joeri Voet, Axel De Wolf, Eva Zidkova Petr Jansky, Rudolf Spacek, Vilma Machova, Ondrej Ludka, Josef Olsr, Lubos Kotik, Blazej Racz, Richard Ferkl, Jan Hubac, Ilja Kotik, Zdenek Monhart, Hana Burianova, Ondrej Jerabek, Jana Pisova, Iveta Petrova, Vratislav Dedek, Michaela Honkova, Petr Podrazil, Petr Reichert, Jindrich Spinar, Miroslav Novak, Vaclav Durdil, Katarina Plocova, Jiri Lastuvka, Jørn Nielsen Steen Husted, Helena Dominguez, Ulrik Hintze, Søren Rasmussen, Næstved Sygehus, Arne Bremmelgaard, John Markenvard, Jan Børger, Jorgen Solgaard, Ebbe Eriksen, Thomas Løkkegaard, Michael Bruun, Jacob Mertz, Morten Schou, Michael Olsen, Pekka Raatikainen Carmela Viitanen, Franck Paganelli Joël Ohayon, Frédéric Casassus, Michel Galinier, Yannick Gottwalles, Philippe Loiselet, Jean-Joseph Muller, Mohamed Bassel Koujan, André Marquand, Sylvain Destrac, Olivier Piot, Nicolas Delarche, Jean-Pierre Cebron, Maxime Guenoun, Dominique Guedj-Meynier, A. 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Rikimaru Oyama, Masato Ageta, Teruaki Mita, Kazuhiko Nagao, Takafumi Mito, Junichi Minami, Mitsunori Abe, Masako Fujii, Makoto Okawa, Tsuneo Fujito, Toshiya Taniguchi, Tenei Ko, Hiroshi Kubo, Mizuho Imamaki, Masahiro Akiyama, Takashi Ueda, Hironori Odakura, Masahiko Inagaki, Yoshiki Katsube, Atsuyuki Nakata, Shinobu Tomimoto, Mitsuhiro Shibuya, Masayuki Nakano, Kenichiro Ito, Masahiro Matsuta, Motoyuki Ishiguro, Taro Minagawa, Masamichi Wada, Hiroaki Mukawa, Masato Mizuguchi, Fumio Okuda, Teruaki Kimura, Kuniaki Taga, Masaaki Techigawara, Morio Igarashi, Hiroshi Watanabe, Toshihiko Seo, Shinya Hiramitsu, Hiroaki Hosokawa, Mitsumoto Hoshiai, Michitaka Hibino, Koichi Miyagawa, Hideki Horie, Nobuyoshi Sugishita, Yukio Shiga, Akira Soma, Kazuo Neya, Tetsuro Yoshida, Kunio Akahane, Sen Adachi, Chiei Takanaka, Saori Matsui, Hirofumi Kanda, Masanori Kaneko, Shiro Nagasaka, Atsushi Taguchi, Shuta Toru, Kazuyuki Saito, Akiko Miyashita, Hiroki Sasaguri, Jin Nariyama, Taketo Hatsuno, Takash Iwase, Kazuki Sato, Kazuya Kawai, Tomobumi Kotani, Tsuyoshi Tsuji, Hirosumi Sakai, Kiyoshi Nishino, Kenichi Ikeda, Kazuo Maeda, Tomohiro Shinozuka, Takeshi Inoue, Koichi Kawakami, Hiromichi Kitazumi, Tsutomu Takagi, Mamoru Hamaoka, Jisho Kojima, Akitoshi Sasaki, Yoshihiro Tsuchiya, Tetsuo Betsuyaku, Koji Higuchi, Masaaki Honda, Koichi Hasegawa, Takao Baba, Kazuaki Mineoi, Toshihiko Koeda, Kunihiko Hirasawa, Toshihide Kumazaki, Akira Nakagomi, Eiji Otaki, Takashi Shindo, Hiroyoshi Hirayama, Chikako Sugimoto, Takashi Yamagishi, Ichiro Mizuguchi, Kazunori Sezaki, Isamu Niwa, Ken Takenaka, Osamu Iiji, Koichi Taya, Hitoshi Kitazawa, samu Ueda, Hirokazu Kakuda, Takuya Ono, Seizo Oriso, Junya Kamata, Toshihiko Nanke, Itaru Maeda, Yoshifusa Matsuura, Hiroki Teragawa, Yasuyuki Maruyama, Kazuo Takei, Hajime Horie, Tetsutaro Kito, Hiroshi Asano, Koji Matsushita, Masaichi Nakamura, Takashi Washizuka, Tomoki Yoshida, Masato Sawano, Shinichi Arima, Hidekazu Arai, Hisanori Shinohara, Hiroyuki Takai, Nobufusa Furukawa, Akira Ota, Kentaro Yamamoto, Kenji Aoki, Taku Yamamoto, Takeaki Kasai, Shunji Suzuki, Shu Suzuki, Nitaro Shibata, Masayuki Watanabe, Yosuke Nishihata, Toru Arino, Masaki Okuyama, Tetsushi Wakiyama, Tomoko Kato, Yasuo Sasagawa, Takeshi Tana, Yoshihito Hayashi, Shinichi Hirota, Yukihiko Abe, Yoshihiro Saito, Hirohide Uchiyama, Hiroshi Takeda, Hiroshi Ono, Shuichi Tohyo, Naoto Hanazono, Seiichi Miyajima, Hisashi Shimono, Takuma Aoyama, Yasunobu Shozawa, Yawara Niijima, Osamu Murai, Hideko Inaba, Katsumasa Nomura, Masatsugu Nozoe, Kazuo Suzuki, Toshiyuki Furukawa, Toshihiko Shiraiwa, Nobuhisa Ito, Shunichi Nagai, Kiyoharu Sato, Shiro Nakahara, Yujin Shimoyama, Naoko Ohara, Teruhiko Kozuka, Hideaki Okita, Masato Endo, Tsutomu Goto, Makoto Hirose, Emiko Nagata, Noriyuki Nakanishi, Toshizumi Mori, Shuichi Seki, Katsuhiro Okamoto, Osamu Moriai, Yoko Emura, Tsuyoshi Fukuda, Haruhiko Date, Shuichi Kawakami, Sho Nagai, Yuya Ueyama, Tetsuro Fudo, Mitsuru Imaizumi, Takuo Ogawa, 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Mori, Toshio Tsubokura, Hiroshi Shudo, Shunichi Fujimoto, Tomohiro Katsuya, Yoshiyuki Furukawa, Hiroshi Hosokawa, Jun Narumi, Kiichiro Yamamoto, Masaki Owari, Takuya Inakura, Takafumi Anno, Kazuyuki Shirakawa, Chi Keong Ching Toon Wei Lim, David Foo, Kelvin Wong, Tan Yuyang, Seil Oh Hui Nam Park, Woo-Shik Kim, HyeYoung Lee, Sung-Won Jang, Dae Hyeok Kim, Jun Kim, DongRyeol Ryu, Jaemin Shim, Dae-Kyeong Kim, Dong Ju Choi, Yong Seog Oh, Myeong-Chan Cho, Hack-Lyoung Kim, Hui-Kyung Jeon, Dong-Gu Shin, Sang Weon Park, Hoon Ki Park, Sang-Jin Han, Jung Hoon Sung, Hyung-Wook Park, Gi-Byoung Nam, Young Keun On, Hong Euy Lim, JaeJin Kwak, Tae-Joon Cha, Taek Jong Hong, Seong Hoon Park, Jung Han Yoon, Nam-Ho Kim, Kee-Sik Kim, Byung Chun Jung, Gyo-Seung Hwang, Chong-Jin Kim, Sakda Rungaramsin Peerapat Katekangplu, Porames Khunrong, Thanita Bunyapipat, Wanwarang Wongcharoen, Pinij Kaewsuwanna, Khanchai Siriwattana, Waraporn Tiyanon, Supalerk Pattanaprichakul, Khanchit Likittanasombat, Doungrat 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G. Lokesh, Mathieu Zuber, Pierre Amarenco, Emmanuel Ellie, James Kadouch, Pierre-Yves Fournier, Jean-Pierre Huberman, Nestor Lemaire, Gilles Rodier, Xavier Vandamme, Igor Sibon, Jean-Philippe Neau, Marie Hélène Mahagne, Antoine Mielot, Marc Bonnefoy, Jean-Baptiste Churet, Vincent Navarre, Frederic Sellem, Gilles Monniot, Jean-Paul Boyes, Bernard Doucet, Michel Martelet, Désiré Obadia, Bernard Crousillat, Joseph Mouallem, Etienne Bearez, Jean Philippe Brugnaux, Alain Fedorowsky, Pierre Nazeyrollas, Jean-Baptiste Berneau, Frédéric Chemin, Sebastien Schellong Harald Darius, Georg Koeniger, Andreas Kopf, Uwe Gerbaulet, Bernd-Thomas Kellner, Thomas Schaefer, Jan Purr, Enno Eißfeller, Heinz-Dieter Zauzig, Peter Riegel, Christoph Axthelm, Gerd-Ulrich Heinz, Holger Menke, Andreas Pustelnik, Stefan Zutz, Wolfgang Eder, Guenter Rehling, Dirk Glatzel, Norbert Ludwig, Petra Sandow, Henning Wiswedel, Cosmas Wildenauer, Steffen Schoen, Toralf Schwarz, Adyeri Babyesiza, Maximilian Kropp, Hans-Hermann Zimny, Friedhelm Kahl, Andreas Caspar, Sabine Omankowsky, Torsten Laessig, Hermann-Josef Hartmann, Gunter Lehmann, Hans-Walter Bindig, Gunter Hergdt, Dietrich Reimer, Joachim Hauk, Holger Michel, Praxis Dres. 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H. Ruiter, Andreas Lucassen, Henk Adriaansen, Maarten Bongaerts, Mathijs Pieterse, Coen van Guldener, Johannes Herrman, S. H. K. P. R. Nierop, Pieter Hoogslag, Walter Hermans, B. E. Groenemeijer, W. Terpstra, Cees Buiks, L. V. A. 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Fisher, Tim Fooks, Richard Kelsall, Neil Paul, Elizabeth Alborough, Michael Aziz, C. Ramesh, Pete Wilson, Simon Franklin, Sue Fairhead, Julian Thompson, Hasan Chowan, Gary Taylor, Dawn Tragen, Matt Parfitt, Claire Seamark, Carolyn Paul, Mark Richardson, Angus Jefferies, Helen Sharp, Hywel Jones, Claire Giles, Matthew Bramley, Philip Williams, Jehad Aldegather, Simon Wetherell, William Lumb, Phil Evans, Frances Scouller, Neil Macey, Stephen Rogers, Yvette Stipp, Richard West, Philip Pinney, Paul Wadeson, John Matthews, Preeti Pandya, Andrew Gallagher, T. Railton, Emyr Davies, Jonathan McClure, Marc Jacobs, Claire Hutton, R. Thompson, Bijoy Sinha, Keith Butter, Susan Barrow, Helen Little, David Russell, Ulka Choudhary, Ikram Haq, Paul Ainsworth, Claire Jones, Phil Weeks, Jane Eden, Lisa Gibbons, Janet Glencross, Alison MacLeod, K. Poland, Conor Mulolland, A. Warke, Paul Conn, D. Burns, R. Smith, R. Kamath, Jonathan Webster, Ian Hodgins, Stephen Vercoe, Paul Roome, Hilary Pinnock, Jayesh Patel, Amar Ali, Nigel Hart, Richard Davies, Nigel De-Sousa, Catherine Neden, Mark Danielsen, Purnima Sharma, Sophia Galloway, Charlotte Hawkins, Raife Oliver, Martin Aylward, Mira Pattni, Gordon Irvine, Shahid Ahmad, Catherine Rothwell, Fiaz Choudhary, Sabrina Khalaque, Stephanie Short, Sharon Peters, Warwick Coulson, Neil Roberts, Amy Butler Steven Coates, Ben Ward, Daniel Jackson, Steve Walton, Diane Shepherd, Toh Wong, Mark Boon, Melanie Deacon, David Cornelius, Sarah Davies, Ben Frankel, Nick Hargreaves, Henry Choi, Jon Sumner, Tim Myhill, Salah Estifanos, Diane Geatch, Justin Wilkinson, Richard Veale, Karen Forshaw, Rob Hirst, Kashif Zaman, Catherine Liley, Rebecca Wastling, Paul McEleny, Andre Beattie, Philip Cooke, Mike Wong, Mark Pugsley, Chaminda Dooldeniya, Greg Rogers, James Bennett, Polly Jacobs, Rajesh Muvva, Matthew Adam, Robin Fox, Nicolas Thomas, Simon Cartwright, Rory Reed, Simon Randfield, Christine A’Court, Ann Flynn, Andrew Halpin, Simon Dobson, Louise Lomax, Minnal Nadaph, Iain Munro, Jane Goram, Helen Stoddart, Phil Simmons, John Shewring, Emma Bowen-Simpkins, Mark Rickenbach, Adam Blenkhorn Bhuwanendu Singh, Penny Astridge, William van Gaal, Walter Abhayaratna, Philip Thomson, Ron Lehman, Jens Kilian, David Coulshed, Andrei Catanchin, David Colquhoun, Hosen Kiat, David Eccleston, John French, Bronte Ayres, Peter Blombery, Thanh Phan, James Rogers, David O’Donnell, Sang Cheol Bae, Harry Gibbs, Patrick Carroll, Greg Starmer, Margaret Arstall, Maurits Binnekamp, Astin Lee, John Eikelboom Robert Luton, Milan Gupta, Amritanshu Shekhar Pandey, Stephen Cheung, Rolland Leader, Philippe Beaudry, Félix Ayala-Paredes, Joseph Berlingieri, John Heath, Germain Poirier, Miranda du Preez, Bradley Schweitzer, Reginald Nadeau, Ripple Dhillon, Tomasz Hruczkowski, Andrea Lavoie, Ratika Parkash, James Cha, Benoit Coutu, Paul MacDonald, Brian Ramjattan, Jorge Bonet, Saul Vizel, Paul Angaran, Sameh Fikry, Ahmed Mowafy Azza Katta, Mazen Tawfik, Moustafa Nawar, Mohamed Sobhy, Seif Kamal Abou Seif, Tarek Khairy, Ahmed Abd El-Aziz, Nasser Taha, Ashraf Reda, Atef Elbahry, Mohamed Setiha, Mohamed Gamal El Din, Magdi Elkhadem, Adel El-Etreby, David Kettles Junaid Bayat, Heidi Siebert, Adrian Horak, Ynez Kelfkens, Riaz Garda, Thayabran Pillay, Michele Guerra, Louis van Zyl, Hendrik Theron, Andrew Murray, Rikus Louw, Deon Greyling, Pindile Mntla, Siddique Ismail, Fayzal Ahmed, Johannes Engelbrecht, Shambu Maharajh, Wessel Oosthuysen, Rehana Loghdey, Veronica Ueckermann, Wael AlAl Mahmeed AbdullahNaeemi, Ghazi Yousef, Nooshin Bazargani, Munther AlOmairi, Rajan Maruthanayagam, Rupesh Singh, Ahmed Naguib, Mohamed Ibrahim, Amrish Agrawal, Mukesh Nathani, Ehab M. Esheiba, Adel Wassef, Rajeev Gupta, Michael Cox Scott Beach, Peter Duffy, Stephen Falkowski, Kevin Ferrick, Miguel Franco, W. Michael Kutayli, Annette Quick, Niraj Sharma, Vance Wilson, Stephen Miller, Mark Alberts, Edwin Blumberg, Roddy Canosa, Ted Gutowski, Rodney Ison, Jorge Garcia, Paul Mullen, Howard Noveck, Pamela Rama, Rajneesh Reddy, Marcus Williams, Daniel Nishijima, Keith Ferdinand, Ihsan Haque, Robert Mendelson, Sridevi Pitta, Daniel Theodoro, Charles Treasure, Moustafa Moustafa, Cas Cader, Walter Pharr, Alisha Oropallo, George Platt, Jaspal Gujral, James Welker, and Firas Koura
Abstract: Background: The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) is a worldwide non-interventional study of stroke prevention in patients with non-valvular AF. Methods and results: 52,080 patients with newly diagnosed AF were prospectively enrolled from 2010 to 2016. 4121 (7.9%) of these patients were recruited in DACH [Germany (n = 3567), Austria (n = 465) and Switzerland (n = 89) combined], and 47,959 patients were from 32 countries in other regions worldwide (ORW). Hypertension was most prevalent in DACH and ORW (85.3% and 75.6%, respectively). Diabetes, hypercholesterolaemia, carotid occlusive disease and vascular disease were more prevalent in DACH patients vs ORW (27.6%, 49.4%, 5.8% and 29.0% vs 21.7%, 40.9%, 2.8% and 24.5%). The use of non-vitamin K antagonist oral anticoagulants (NOACs) increased more in DACH over time. Management of vitamin K antagonists was suboptimal in DACH and ORW (time in therapeutic range of INR ≥ 65% in 44.6% and 44.4% of patients or ≥ 70% in 36.9% and 36.0% of patients, respectively). Adjusted rates of cardiovascular mortality and MI/ACS were higher in DACH while non-haemorrhagic stroke/systemic embolism was lower after 2-year follow-up. Conclusions: Similarities and dissimilarities in AF management and clinical outcomes are seen in DACH and ORW. The increased use of NOAC was associated with a mismatch of risk-adapted anticoagulation (over-and-undertreatment) in DACH. Suboptimal control of INR requires educational activities in both regional groups. Higher rates of cardiovascular death in DACH may reflect the higher risk profile of these patients and lower rates of non-haemorrhagic stroke could be associated with increased NOAC use. Graphical abstract: [Figure not available: see fulltext.].
Published: 2023

57. Reducing Technology-Induced Errors: Organizational and Health Systems Approaches.

Author: Elizabeth M. Borycki, Yalini Senathirajah, Andre W. Kushniruk, Sari Palojoki, Kaija Saranto, and Hiroshi Takeda
Published: 2016
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58. Large-Time Asymptotic Behaviors for Linear Blackstock’s Model of Thermoviscous Flow

Author: Wenhui Chen and Hiroshi Takeda
Subjects: Mathematics - Analysis of PDEs, Control and Optimization, Applied Mathematics, FOS: Mathematics, Analysis of PDEs (math.AP)
Abstract: In the classical theory of acoustic waves, Blackstock's model was proposed in 1963 to characterize the propagation of sound in thermoviscous fluids. In this paper, we investigate large-time asymptotic behaviors of the linear Cauchy problem for general Blackstock's model (that is, without Becker's assumption on monatomic perfect gases). We derive first- and second-order asymptotic profiles of solution as $t\gg1$ by applying refined WKB analysis and Fourier analysis. Our results not only improve optimal estimates in [Chen-Ikehata-Palmieri, \emph{Indiana Univ. Math. J.} (2023)] for lower dimensional cases, but also illustrate the optimal leading term and novel second-order profiles of solution with additional weighted $L^1$ data.
Published: 2023

59. Antidepressant effects of Enterococcus faecalis 2001 through the regulation of prefrontal cortical myelination via the enhancement of CREB/BDNF and NF-κB p65/LIF/STAT3 pathways in olfactory bulbectomized mice

Author: Kohei Takahashi, Kazuhiro Kurokawa, Lihua Hong, Kazuya Miyagawa, Atsumi Mochida-Saito, Masahiro Iwasa, Hiroyuki Iwasa, Osamu Nakagawasai, Takeshi Tadano, Hiroshi Takeda, and Minoru Tsuji
Subjects: STAT3 Transcription Factor, Depressive Disorder, Major, Depression, Brain-Derived Neurotrophic Factor, NF-kappa B, Prefrontal Cortex, Hippocampus, Leukemia Inhibitory Factor, Olfactory Bulb, Antidepressive Agents, Disease Models, Animal, Mice, Psychiatry and Mental health, Enterococcus faecalis, Animals, Humans, Cyclic AMP Response Element-Binding Protein, Biological Psychiatry
Abstract: A therapeutic strategy through the gut-brain axis has been proven to be effective in treatment for depression. In our previous study, we demonstrated that Enterococcus faecalis 2001 (EF-2001) prevents colitis-induced depressive-like behavior through the gut-brain axis in mice. More recently, we found that demyelination in the prefrontal cortex (PFC) was associated with depressive-like behavior in an animal model of major depressive disorder, olfactory bulbectomized (OBX) mice. The present study investigated the effects of EF-2001 on depressive-like behaviors in OBX mice and the underlying molecular mechanisms from the perspective of myelination in the PFC. OBX mice exhibited depressive-like behaviors in the tail-suspension, splash, and sucrose preference tests, and decreased myelin and paranodal proteins along with mature oligodendrocytes in the PFC. These behavioral and biochemical changes were all prevented by treatment with EF-2001. Further, EF-2001 treatment increased brain-derived neurotrophic factor (BDNF) and leukemia inhibitory factor (LIF) in the PFC. Interestingly, an immunohistochemical analysis revealed enhanced phospho (p) -cAMP-responsive element binding protein (CREB) expression in neurons, p-nuclear factor-kappa B (NFκB) p65 (Ser536) expression in astrocytes, and p-signal transducer and activator of transcription 3 (STAT3) (Ty705) expression in mature oligodendrocytes in the PFC of OBX mice. From these results, we suggest that EF-2001 administration prevents depressive-like behaviors by regulating prefrontal cortical myelination via the enhancement of CREB/BDNF and NFκB p65/LIF/STAT3 pathways. Our findings strongly support the idea that a therapeutic strategy involving the gut microbiota may be a promising alternative treatment for alleviating symptoms of depression.
Published: 2022

60. Asymptotic behaviors for the Jordan–Moore–Gibson–Thompson equation in the viscous case

Author: Wenhui Chen and Hiroshi Takeda
Subjects: Mathematics - Analysis of PDEs, Applied Mathematics, FOS: Mathematics, Analysis, Analysis of PDEs (math.AP)
Abstract: In this paper, we study large-time behaviors for a fundamental model in nonlinear acoustics, precisely, the viscous Jordan-Moore-Gibson-Thompson (JMGT) equation in the whole space $\mathbb{R}^n$. This model describes nonlinear acoustics in perfect gases under irrotational flow and equipping Cattaneo's law of heat conduction. By employing refined WKB analysis and Fourier analysis, we derive first- and second-order asymptotic profiles of solution to the Moore-Gibson-Thompson (MGT) equation as $t\gg 1$, which illustrates novel optimal estimates for the solutions even subtracting its profiles. Concerning the nonlinear JMGT equation, via suggesting a new decomposition of nonlinear portion, we investigate the existence and large-time profiles of global (in time) small data Sobolev solutions with suitable regularity. These results help bridge a new connection between the JMGT equation and diffusion-waves as $t\gg1$.
Published: 2023

61. Multinational Observational Study to Understand Insulin Treatment Intensification: Japanese Subgroup Analysis of the MOSAIc Study

Author: Ikuro, Matsuba, Takehiro, Kawata, Miho, Ajima, Shinichi, Umezawa, Mizuki, Kaneshiro, Taro, Asakura, Hideo, Machimura, Tasuku, Sawa, Keiji, Tanaka, Hiroshi, Takeda, Takeshi, Imaoka, and Akira, Kanamori
Subjects: Endocrinology, Diabetes and Metabolism, Internal Medicine
Abstract: MOSAIc was a multinational, non-interventional, prospective, observational cohort study designed to provide an understanding of the specific challenges associated with intensification of initial insulin therapy in patients with type 2 diabetes mellitus (T2DM). We present a sub-analysis of Japanese patients from MOSAIc, with data analyzed longitudinally over 2 years, to provide insight on how T2DM treatment is intensified.Japanese patients with T2DM receiving any insulin therapy for at least 3 months were eligible for study inclusion. Baseline and clinical data were collected during an initial baseline visit and during four subsequent prospective visit windows (within ± 3 months) at 6, 12, 18, and 24 months. Treatment intensification was defined as addition of new insulin, increase in insulin dosage (1-unit change or 10% compared with the previous visit), increase in insulin injection frequency, and/or addition of non-insulin antihyperglycemic agents.Of 116 Japanese patients who completed the study, 50.0% (n = 58) received treatment intensification. Baseline characteristics of patients with treatment intensification included a longer duration of diabetes, higher incidence of baseline microvascular complications, and higher HbA1c compared to those without intensification. There was no significant difference in HbA1c change from baseline between the two groups at any post-baseline visit. Insulin intensification accounted for 61.2% of treatment changes, with non-insulin-related intensification accounting for 36.2% of treatment changes. An increase in insulin dose was the most frequent treatment change (51.7%), followed by the addition of new insulin (22.4%), and an increase in insulin injection frequency (6.9%).Real-world data from Japanese patients with T2DM who received treatment intensification showed that an increase in insulin dose and the addition of new insulin were the most frequent treatment intensification methods. HbA1c was maintained through 2 years of treatment.NCT01400971, ClinicalTrials.gov.
Published: 2022

62. Analyzing the Antinociceptive Effect of Analgesics Using a Modified Hot-Plate Test in Mice

Author: Iwao Arai, Minoru Tsuji, Hiroshi Takeda, and Saburo Saito
Published: 2023

63. Evaluating the benefit of introducing medical clerks as transcriptionists to assist physicians in outpatient clinics: A quantitative analysis of medical records by counting characters.

Author: Satoko Kasahara, Kayoko Yoshizaki, Teppei Yamashita, and Hiroshi Takeda
Published: 2013
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64. Effects of Gadolinium Deposition in the Brain on Motor or Behavioral Function: A Mouse Model

Author: Yusuke Inoue, Minoru Tsuji, Akira Kunimatsu, Kazuya Miyagawa, Kuni Ohtomo, Haruto Sugawara, Hiroshi Takeda, Kohei Takahashi, Shigeru Kiryu, Osamu Abe, Hiroyuki Akai, Koichiro Yasaka, Atsumi Mochida-Saito, and Kazuhiro Kurokawa
Subjects: business.industry, Gadolinium, media_common.quotation_subject, chemistry.chemical_element, chemistry, Biophysics, Medicine, Contrast (vision), Radiology, Nuclear Medicine and imaging, sense organs, skin and connective tissue diseases, business, Deposition (chemistry), media_common
Abstract: Repeated injection of gadolinium-based contrast agents did not cause any motor or behavioral changes, whether the agents were linear or macrocyclic.
Published: 2021

65. Asymptotic behaviors of global solutions for a semilinear diffusion equation in the de Sitter spacetime

Author: Makoto Nakamura and Hiroshi Takeda
Subjects: Physics, General Relativity and Quantum Cosmology, Diffusion equation, Spacetime, De Sitter universe, General Mathematics, 010102 general mathematics, 0103 physical sciences, 010307 mathematical physics, 0101 mathematics, 01 natural sciences, Mathematical physics
Abstract: A semilinear diffusion equation is considered in the de Sitter spacetime with the spatially flat curvature. Global solutions for small initial data and their asymptotic behaviors in high order are obtained. Some effects of the spatial expansion and contraction are studied through the problem.
Published: 2021

66. Global existence results for semi-linear structurally damped wave equations with nonlinear convection

Author: Tuan Anh Dao and Hiroshi Takeda
Subjects: Physics, Nonlinear system, Small data, General Mathematics, Mathematical analysis, Principal part, Initial value problem, Damped wave, Diffusion (business), Wave equation, Constant (mathematics), Analysis
Abstract: In this paper, we consider the Cauchy problem for semi-linear wave equations with structural damping term [Formula: see text], where [Formula: see text] is a constant. As is now well known, the linear principal part brings both the diffusion phenomenon and the regularity loss of solutions. This implies that, for the nonlinear problems, the choice of solution spaces plays an important role to obtain the global solutions with the sharp decay properties in time. Our main purpose in this paper is to prove the global (in time) existence of solutions for the small data and their decay properties for the supercritical nonlinearities.
Published: 2021

67. A Tabletop-Based Real-World-Oriented Interface.

Author: Hiroshi Takeda, Hidetoshi Miyao, Minoru Maruyama, and David K. Asano
Published: 2011
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68. Updated Topics in Healthcare Informatics.

Author: Hiroshi Takeda
Published: 2010
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69. A Scheme for Assuring Lifelong Readability in Computer Based Medical Records.

Author: Yasushi Matsumura, Noriyuki Kurabayashi, Tetsuya Iwasaki, Shuichi Sugaya, Kanayo Ueda, Takahiro Mineno, and Hiroshi Takeda
Published: 2010
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70. FGFR2 maintains cancer cell differentiation via AKT signaling in esophageal squamous cell carcinoma

Author: Masaya Sugiyama, Hideaki Kinugasa, Naoya Sakamoto, Kenichi Morikawa, Takuya Sho, Koji Ogawa, Hiroshi Takeda, Masashi Mizokami, Shunsuke Ohnishi, Seiji Naganuma, Shinya Ohashi, Mitsuteru Natsuizaka, Osamu Maehara, Megumi Kimura, Naoto Okubo, Goki Suda, Gouki Kanbe, Taku Shigesawa, Shingo Kagawa, and Masato Nakai
Subjects: musculoskeletal diseases, Gene isoform, Cancer Research, Epithelial-Mesenchymal Transition, Esophageal Neoplasms, Biology, Fibroblast growth factor, Cell Line, Tumor, medicine, Humans, Receptor, Fibroblast Growth Factor, Type 2, Receptor, neoplasms, Protein kinase B, Cell Proliferation, Pharmacology, Gene knockdown, Cancer, Cell Differentiation, medicine.disease, digestive system diseases, Gene Expression Regulation, Neoplastic, Oncology, Fibroblast growth factor receptor, embryonic structures, Cancer cell, Carcinoma, Squamous Cell, Cancer research, Molecular Medicine, Esophageal Squamous Cell Carcinoma, Proto-Oncogene Proteins c-akt, Research Paper
Abstract: Fibroblast growth factors (FGFs) and their receptors (FGFRs) are important for signaling to maintain cancer stem-like cells (CSCs) in esophageal squamous cell carcinoma (ESCC). However, which FGF receptor, 1, 2, 3, 4, and L1, is essential or whether FGFRs have distinct different roles in ESCC-CSCs is still in question. This study shows that FGFR2, particularly the IIIb isoform, is highly expressed in non-CSCs. Non-CSCs have an epithelial phenotype, and such cells are more differentiated in ESCC. Further, FGFR2 induces keratinocyte differentiation through AKT but not MAPK signaling and diminishes CSC populations. Conversely, knockdown of FGFR2 induces epithelial-mesenchymal transition (EMT) and enriches CSC populations in ESCC. Finally, data analysis using The Cancer Genome Atlas (TCGA) dataset shows that expression of FGFR2 significantly correlated with cancer cell differentiation in clinical ESCC samples. The present study shows that each FGFR has a distinct role and FGFR2-AKT signaling is a key driver of keratinocyte differentiation in ESCC. Activation of FGFR2-AKT signaling could be a future therapeutic option targeting CSC in ESCC.
Published: 2021

71. Template-based Data Entry for General Description in Medical Records and Data Transfer to Data Warehouse for Analysis.

Author: Yasushi Matsumura, Shigeki Kuwata, Yuichiro Yamamoto, Kazunori Izumi, Yasushi Okada, Michihiro Hazumi, Sachiko Yoshimoto, Takahiro Mineno, Munetoshi Nagahama, Ayumi Fujii, and Hiroshi Takeda
Published: 2007
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72. Kampo treatment for functional dyspepsia: focusing on rikkunshito '1st International Symposium on Kampo Medicine'

Author: Makoto Arai, Hiroshi Takeda, Hidekazu Suzuki, Jae‐Woo Park, and Tetsuro Oikawa
Subjects: General Medicine
Published: 2022

73. Donepezil prevents olfactory dysfunction and α-synuclein aggregation in the olfactory bulb by enhancing autophagy in zinc sulfate-treated mice

Author: Kohei Takahashi, Minoru Tsuji, Osamu Nakagawasai, Soh Katsuyama, Lihua Hong, Kazuya Miyagawa, Kazuhiro Kurokawa, Atsumi Mochida-Saito, Hiroshi Takeda, and Takeshi Tadano
Subjects: Behavioral Neuroscience, Mice, Olfaction Disorders, Tyrosine 3-Monooxygenase, alpha-Synuclein, Acetylcholinesterase, Autophagy, Animals, Ribosomal Protein S6 Kinases, 70-kDa, Donepezil, AMP-Activated Protein Kinases, Olfactory Bulb, Zinc Sulfate
Abstract: Alzheimer's disease is associated with marked olfactory dysfunction observed in the early stages. Clinical studies reported that acetylcholinesterase inhibitor donepezil (DNP) attenuated this deficit; however, the underlying mechanism remains unclear. Herein, we aimed to examine the effects and underlying mechanisms of DNP on olfactory deficits in zinc sulfate (ZnSO
Published: 2022

74. Smoothing effect and large time behavior of solutions to nonlinear elastic wave equations with viscoelastic term

Author: Yoshiyuki Kagei and Hiroshi Takeda
Subjects: Mathematics - Analysis of PDEs, Applied Mathematics, FOS: Mathematics, Analysis, Analysis of PDEs (math.AP)
Abstract: The Cauchy problem for a nonlinear elastic wave equations with viscoelastic damping terms is considered on the 3 dimensional whole space. Decay and smoothing properties of the solutions are investigated when the initial data are sufficiently small; and asymptotic profiles as $t \to \infty$ are also derived.
Published: 2022

75. Protective effect of ISO-1 with inhibition of RIPK3 up-regulation and neutrophilic accumulation on acetaminophen-induced liver injury in mice

Author: Osamu Maehara, Naoto Okubo, Jun Nishihira, Hiroshi Takeda, and Tatsuya Ohkawara
Subjects: Male, 0301 basic medicine, Neutrophils, Acetates, Liver injury, Pharmacology, Protective Agents, RIPK3, Toxicology, Mice, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, medicine, Animals, Humans, Macrophage, Oxazoles, Acetaminophen, Macrophage migration inhibitory factor, ISO 1, Chemistry, Kinase, digestive, oral, and skin physiology, General Medicine, medicine.disease, Up-Regulation, Mice, Inbred C57BL, 030104 developmental biology, Chemical and Drug Induced Liver Injury, Chronic, Receptor-Interacting Protein Serine-Threonine Kinases, Shock (circulatory), Models, Animal, ISO-1, medicine.symptom, 030217 neurology & neurosurgery, medicine.drug
Abstract: Overdose use of acetaminophen (APAP) often occurs a severe liver injury, and its liver injury is lethal in some cases. Macrophage migration inhibitory factor (MIF) is expressed in a variety of cells and has multifunctional roles. However, the role of MIF in APAP-induced liver injury has not been fully investigated. In this study, we investigated whether treatment with (S,R)-3-(4-hydroxyphenil)-4,5dihydro-5-isoxazole acetic acid methyl ester (ISO-1), a MIF inhibitor, protected mice from acute APAP-induced liver injury. Acute liver injury was induced by injection of APAP (300 mg/kg body weight). Mice were treated with a single injection of ISO-1(15 mg/kg body weight) 1 h (h) before APAP administration. Histological, biochemical and molecular analyses were performed in liver of mice 12 h after APAP administration. ISO-1 remarkably improved the histological findings of APAP-induced liver injury in mice. The increases in serum levels of alanine aminotransferase (ALT), and macrophage inflammatory protein-2 (MIP-2) by APAP were inhibited by ISO-1. In addition, ISO-1 reduced the increased number of the myeloperoxidase-staining cells and that of TUNEL-positive staining cells in the liver of mice with APAP-induced liver injury. Up-regulation of hepatic receptor interacting protein kinase (RIPK)3 and heat shock protein70 by APAP was suppressed in the liver of mice given ISO-1. These results provide the additional evidence that inhibition of MIF activity may be clinically effective for treatment of acute APAP-induced liver injury. (C) 2020 Elsevier B.V. All rights reserved.
Published: 2021

76. Development of predicting evaluation platform of advanced driver safety assist systems using integrated virtual traffic environments.

Author: Yoshimi Furukawa, Hiroshi Takeda, Naohiro Yuhara, Sunao Chikamori, Masato Abe, and Toichi Sawada
Published: 2004
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77. Healthcare Public Key Infrastructure (HPKI) and Non-profit Organization (NPO): Essentials for Healthcare Data Exchange.

Author: Hiroshi Takeda, Yasushi Matsumura, Katsuhiko Nakagawa, Tadamasa Teratani, Qiyan Zhang, Hideo Kusuoka, and Masami Matsuoka
Published: 2004
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78. Decay estimates of solutions to nonlinear elastic wave equations with viscoelastic terms in the framework of L-Sobolev spaces

Author: Yoshiyuki Kagei and Hiroshi Takeda
Subjects: Applied Mathematics, Analysis
Published: 2023

79. Brexpiprazole prevents colitis-induced depressive-like behavior through myelination in the prefrontal cortex

Author: Kohei, Takahashi, Lihua, Hong, Kazuhiro, Kurokawa, Kazuya, Miyagawa, Atsumi, Mochida-Saito, Hiroshi, Takeda, and Minoru, Tsuji
Subjects: Pharmacology, Mice, Serotonin, Disease Models, Animal, Depression, Brain-Derived Neurotrophic Factor, Animals, Prefrontal Cortex, Colitis, Inflammatory Bowel Diseases, Biological Psychiatry
Abstract: Patients with inflammatory bowel disease (IBD) have higher rates of psychiatric pathology including depression. The dextran sulfate sodium (DSS)-treated mice exhibit IBD- and depressive-like phenotypes. A disturbed intestinal environment causes a decrease in serotonin and abnormal myelination in the brain, along with depressive-like behavior in rodents. However, the involvement of these factors in DSS-induced depressive-like behavior in mice remains unclear. In this study, we examined whether myelin proteins in the prefrontal cortex (PFC) and hippocampi were altered in DSS-treated mice, along with the changes in the serotonergic system in the PFC by western blotting and HPLC. The effects of brexpiprazole (Brx), a serotonin modulator, on DSS-induced depressive-like behavior using the tail-suspension test were evaluated. Subsequently, we investigated Brx's effects on the levels of myelin, nodal proteins, and neurotrophic molecules in the PFC with western blotting, and examined the altered node of Ranvier formation by immunohistochemistry. DSS-treated mice showed a reduction in myelin and nodal proteins, dysfunction of the serotonergic system, and impaired formation of the nodes of Ranvier in the PFC. Brx administration prevented the DSS-induced depressive-like behavior and demyelination in the PFC. However, the Brx-mediated effects were inhibited by the selective 5-HT
Published: 2023

80. Retrospective Analysis of the Renoprotective Effects of Long-Term Use of Six Types of Sodium–Glucose Cotransporter 2 Inhibitors in Japanese Patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease

Author: Kouta Aoyama, Shun Ito, Masaaki Miyakawa, Kouichi Tamura, Nobumichi Saito, Tomoya Umezono, Shinichi Umezawa, Toshimasa Hishiki, Fuyuki Minagawa, Hareaki Yamamoto, Masao Toyoda, Daisuke Suzuki, Kazuo Kobayashi, Keiichi Chin, Masahiro Takihata, Togo Aoyama, Kazuyoshi Sato, Hiroshi Takeda, Hideo Machimura, Yutaka Hatori, Hisakazu Degawa, Takayuki Furuki, Kohsuke Minamisawa, Masahiro Hayashi, Yoshiro Hamada, Hiroyuki Sakai, Yoshiro Suzuki, Tomohiko Kanaoka, Akira Kanamori, and Nobuo Hatori
Subjects: medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, urologic and male genital diseases, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Japan, Internal medicine, Diabetes mellitus, medicine, Retrospective analysis, Humans, In patient, 030212 general & internal medicine, Renal Insufficiency, Chronic, Sodium-Glucose Transporter 2 Inhibitors, Retrospective Studies, business.industry, nutritional and metabolic diseases, Type 2 Diabetes Mellitus, medicine.disease, Medical Laboratory Technology, Diabetes Mellitus, Type 2, Sodium/Glucose Cotransporter 2, Renal protection, Cotransporter, business, Glomerular Filtration Rate, Kidney disease
Abstract: Aim: Sodium–glucose cotransporter 2 inhibitors (SGLT2is) provide renal protection in patients with type 2 diabetes mellitus (T2DM). The aim of this study was to elucidate the renal effects of long-...
Published: 2021

81. The Combined Usage of the Global Leadership Initiative on Malnutrition Criteria and Controlling Nutrition Status Score in Acute Care Hospitals

Author: Hiroshi Takeda, Satomi Kumagai, Takahito Iwai, Mutsumi Nishida, Takanori Teshima, Junichi Sugita, Asako Mitani, and Toshiaki Shichinohe
Subjects: medicine.medical_specialty, Concordance, Combined use, Nutritional Status, Medicine (miscellaneous), GLIM, Disease, Nutritional Interventions, Internal medicine, Acute care, Global Leadership Initiative on Malnutrition criteria, Humans, Controlling Nutrition Status score, Medicine, Retrospective Studies, Inflammation, Original Paper, Nutrition and Dietetics, Clinical outcome, business.industry, Malnutrition, medicine.disease, Hospitals, Leadership, Nutrition Assessment, Subjective Global Assessment, Etiology, business
Abstract: Introduction: The Global Leadership Initiative on Malnutrition (GLIM) lacks reliable blood tests for evaluating the nutrition status. We retrospectively compared the GLIM criteria, Controlling Nutrition Status (CONUT) score, and Subjective Global Assessment (SGA) to establish effective malnutrition screening and provide appropriate nutritional interventions according to severity. Methods: We classified 177 patients into 3 malnutrition categories (normal/mild, moderate, and severe) according to the GLIM criteria, CONUT score, and SGA. We investigated the malnutrition prevalence, concordance of malnutrition severity, predictability of clinical outcome, concordance by etiology, and clinical outcome by inflammation. Results: The highest prevalence of malnutrition was found using the GLIM criteria (87.6%). Concordance of malnutrition severity was low between the GLIM criteria and CONUT score. Concordance by etiology was low in all groups but was the highest in the “acute disease” group. The area under the curve of clinical outcome and that of the “with inflammation group” were significantly higher when using the CONUT score versus using the other tools (0.679 and 0.683, respectively). Conclusion: The GLIM criteria have high sensitivity, while the CONUT score can effectively predict the clinical outcome of malnutrition. Their combined use can efficiently screen for malnutrition and patient severity in acute care hospitals.
Published: 2021

82. Clinical utility of thoracoscopy in elderly tuberculous pleurisy patients under local anesthesia

Author: Kazuyoshi Kuwano, Keisuke Saito, Takuya Inagaki, Yoshitaka Seki, Shota Fujimoto, Hiroshi Takeda, Aya Seki, Syuji Sato, Ikumi Fujisaki, Yumie Yamanaka, Kyuto Odashima, Masami Yamada, Taisuke Kazuyori, Takeo Ishikawa, Akihito Sato, and Sachi Matsubayashi
Subjects: 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, Tuberculosis, Pleural effusion, 030106 microbiology, Caseous necrosis, Mycobacterium tuberculosis, 03 medical and health sciences, 0302 clinical medicine, Japan, Thoracoscopy, Humans, Medicine, Pharmacology (medical), Local anesthesia, 030212 general & internal medicine, Pathological, Aged, Retrospective Studies, Aged, 80 and over, medicine.diagnostic_test, biology, business.industry, Tuberculosis, Pleural, Pleural cavity, medicine.disease, biology.organism_classification, Surgery, Pleural Effusion, Infectious Diseases, medicine.anatomical_structure, Pleura, business, Anesthesia, Local
Abstract: Introduction Diagnosing tuberculous pleurisy is important in Japan because it currently has a moderate tuberculosis prevalence. However, physicians often have difficulty making a diagnosis. It was reported that thoracoscopy under local anesthesia is useful for the diagnosis of tuberculous pleurisy, but there are no reports focusing on elderly patients. Methods In this study, the usefulness of thoracoscopy under local anesthesia was evaluated in elderly patients. Among 170 patients who underwent thoracoscopy under local anesthesia at our hospital during 11 years from January 2008 to December 2018, those aged 75 years or older (n = 75) were investigated retrospectively. Results A total of 55 patients underwent thoracoscopy under local anesthesia for detailed examination of pleural effusion of unknown cause. Of these, 18 were diagnosed as tuberculous pleurisy. The median age was 82 years (range: 75–92 years). The diagnosis of tuberculous pleurisy was made in 11 patients in whom Mycobacterium tuberculosis was detected and in four patients whose pathological findings indicated epithelioid granuloma accompanied by caseous necrosis. Clinical diagnosis was made in the remaining three patients based on thoracoscopic findings of the pleural cavity and a high level of adenosine deaminase in pleural fluid. No serious complications attributable to the examination were observed in any patient. Conclusions Thoracoscopy under local anesthesia was useful for the diagnosis of tuberculous pleurisy in elderly patients, with useful information being also obtained for the treatment of tuberculosis.
Published: 2021

83. Core Curriculum Comparisons in Master Degree Programs for Patient Safety.

Author: Qiyan Zhang and Hiroshi Takeda
Published: 2017
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84. Dynamic Viewer of Medical Events in Electronic Medical Record.

Author: Yasushi Matsumura, Shigeki Kuwata, Hideo Kusuoka, Yasushi Takahashi, Hisashi Onishi, Toshio Kawamoto, and Hiroshi Takeda
Published: 2001
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85. PACS Linked to EPR.

Author: Hiroshi Kondoh, Hiroshi Takeda, Yasushi Matsumura, Shigeki Kuwata, Hideaki Yoshimura, Yoshifumi Narumi, Hironobu Nakamura, Yasuhiko Okura, Kiyonari Inamura, Takeshi Washiashi, and Shinichi Okada
Published: 2001
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86. Effects of feeding condition on the myocardial and hepatic accumulation of radioiodine-labeled BMIPP in mice

Author: Songji Zhao, Hiroshi Takeda, Mie Nishimura, Yoichi Shimizu, Nagara Tamaki, Kazuaki Yamasaki, and Yuji Kuge
Subjects: chemistry.chemical_classification, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Nuclear imaging, Fatty acid, General Medicine, Scintigraphy, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, chemistry, Fatty acid analog, 030220 oncology & carcinogenesis, Internal medicine, Medicine, Radiology, Nuclear Medicine and imaging, business
Abstract: 123I-15-(p-iodophenyl)-3(R,S)-methylpentadecanoic acid ([123I]BMIPP), a fatty acid analog, is widely used for the diagnosis of cardiac diseases. Feeding condition is one of the important factors in the myocardial fatty acid uptake, which may also affect myocardial accumulation of [123I]BMIPP and image quality of [123I]BMIPP scintigraphy. However, the relationship between the myocardial accumulation of [123I]BMIPP and the feeding condition is not entirely clear. Therefore, we determined the myocardial accumulation of [125I]BMIPP in mice at various metabolic statuses induced by fasting in comparison with the hepatic accumulation. Fed or fasted (6-, 12-, and 24-h fasted) mice were intravenously injected with [125I]BMIPP (35.2–75.0 kBq, 4 nmol). Radioactivities in the heart and liver were measured at 1, 5, 10, 30, 60, and 120 min after the injection (n = 5–15/time point for each group), and then, the heart-to-liver (H/L) ratios were calculated. The myocardial accumulation level of [125I]BMIPP in the fed group was almost the same as that in the 6-h-fasted group at each time point, although it was decreased by 12- and 24-h fasting. The H/L ratios of [125I]BMIPP accumulation level were significantly decreased by fasting (1.92 ± 0.22, 1.45 ± 0.13, 1.12 ± 0.13, and 0.91 ± 0.15 at 10 min, and 3.30 ± 0.62, 2.09 ± 0.35, 1.79 ± 0.34, and 1.27 ± 0.06 at 30 min after the injection, respectively, for the fed group and the 6-, 12-, and 24-h-fasted groups; p
Published: 2020

87. Vulnerability to psychological stress-induced anorexia in female mice depends on blockade of ghrelin signal in nucleus tractus solitarius

Author: Tomohisa Hattori, Hiroshi Takeda, Chihiro Yamada, Miwa Nahata, and Seiichi Iizuka
Subjects: Male, 0301 basic medicine, sex differences, medicine.medical_specialty, mice, medicine.drug_class, Estrogen receptor, Anorexia, rikkunshito, Eating, 03 medical and health sciences, stress, 0302 clinical medicine, Internal medicine, Solitary Nucleus, medicine, Animals, Pharmacology, business.industry, digestive, oral, and skin physiology, medicine.disease, Research Papers, Growth hormone secretion, Blockade, Mice, Inbred C57BL, Eating disorders, 030104 developmental biology, Endocrinology, Estrogen, anorexia, ghrelin, Female, Ghrelin, medicine.symptom, business, Stress, Psychological, hormones, hormone substitutes, and hormone antagonists, 030217 neurology & neurosurgery, Research Paper, Hormone
Abstract: Background and Purpose Women have a higher incidence of eating disorders than men. We investigated whether the effects of ghrelin on feeding are affected by sex and stress, and to elucidate the mechanisms that may cause sex differences in stress‐mediated anorexia, focusing on ghrelin. Experimental Approach Acylated ghrelin was administered to naïve and psychologically stressed male and female C57BL/6J mice, followed by measurements of food intake and plasma hormone levels. Ovariectomy was performed to determine the effects of ovary‐derived oestrogen on stress‐induced eating disorders in female mice. The numbers of Agrp or c‐Fos mRNA‐positive cells and estrogen receptor α/c‐Fos protein‐double‐positive cells were assessed. Key Results Ghrelin administration to naïve female mice caused a higher increase in food intake, growth hormone secretion, Agrp mRNA expression in the arcuate nucleus and c‐Fos expression in the nucleus tractus solitarius (NTS) than in male mice. In contrast, psychological stress caused a more sustained reduction in food intake in females than males. The high sensitivity of naïve females to exogenous ghrelin was attenuated by stress exposure. The stress‐induced decline in food intake was not abolished by ovariectomy. Estrogen receptor‐α but not ‐β antagonism prevented the decrease in food intake under stress. Estrogen receptor‐α/c‐Fos‐double‐positive cells in the NTS were significantly increased by stress only in females. Conclusion and Implications Stress‐mediated eating disorders in females may be due to blockade of ghrelin signalling via estrogen receptor‐α activation in the NTS. Targeting the ghrelin signal in the brain could be a new treatment strategy to prevent these disorders., Schematic mechanism of feeding control via ghrelin reactivity in naive and stressed mice
Published: 2020

88. Blood pressure after treatment with sodium–glucose cotransporter 2 inhibitors influences renal composite outcome: Analysis using propensity score‐matched models

Author: Hareaki Yamamoto, Akira Kanamori, Daisuke Suzuki, Masao Toyoda, Nobuo Hatori, Hisakazu Degawa, Kazuyoshi Sato, Takayuki Furuki, Hiroyuki Sakai, Kouta Aoyama, Kouichi Tamura, Keiichi Chin, Masahiro Takihata, Shun Ito, Fuyuki Minagawa, Masahiro Hayashi, Toshimasa Hishiki, Kohsuke Minamisawa, Yoshiro Suzuki, Hiroshi Takeda, Togo Aoyama, Hideo Machimura, Yutaka Hatori, Shinichi Umezawa, Masaaki Miyakawa, Yoshiro Hamada, Tomoya Umezono, and Kazuo Kobayashi
Subjects: Blood Glucose, Male, medicine.medical_specialty, Mean arterial pressure, Diabetic Cardiomyopathies, Endocrinology, Diabetes and Metabolism, Urology, Renal function, Blood Pressure, Diabetic nephropathy, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Diabetic Nephropathies, 030212 general & internal medicine, Renal Insufficiency, Chronic, Propensity Score, Sodium-Glucose Transporter 2 Inhibitors, Retrospective Studies, Glycated Hemoglobin, business.industry, Articles, General Medicine, Middle Aged, Prognosis, medicine.disease, Clinical Science and Care, Blood pressure, Diabetes Mellitus, Type 2, Sodium–glucose cotransporter 2 Inhibitors, Propensity score matching, Albuminuria, Original Article, Female, medicine.symptom, business, Biomarkers, Follow-Up Studies, Glomerular Filtration Rate, Kidney disease
Abstract: Aims/Introduction Sodium–glucose cotransporter 2 inhibitors (SGLT2i) improve renal outcome in patients with type 2 diabetes mellitus, but the mechanism is not fully understood. The aim of this retrospective study was to assess the association of achieved blood pressure with renal outcomes in Japanese type 2 diabetes mellitus patients with chronic kidney disease. Materials and Methods We assessed 624 Japanese type 2 diabetes mellitus patients with chronic kidney disease taking SGLT2i for >1 year. The patients were classified as those with post‐treatment mean arterial pressure (MAP) of ≥92 mmHg (n = 344) and those with MAP of, Incidence of renal composite outcome and changes in logarithmic value of the albumin‐to‐creatinine ratio and estimated glomerular filtration rate.
Published: 2020

89. Lenvatinib suppresses cancer stem-like cells in HCC by inhibiting FGFR1–3 signaling, but not FGFR4 signaling

Author: Takashi Kitagataya, Ren Yamada, Koji Yamamoto, Goki Suda, Masatsugu Ohara, Akihisa Nakamura, Machiko Umemura, Masaya Sugiyama, Kenichi Morikawa, Kazuharu Suzuki, Masato Nakai, Koji Ogawa, Naoki Kawagishi, Osamu Maehara, Naoya Sakamoto, Mitsuteru Natsuizaka, Masashi Mizokami, Takuya Sho, Hiroshi Takeda, Shunsuke Ohnishi, Megumi Kimura, Tomoe Shimazaki, and Taku Shigesawa
Subjects: 0301 basic medicine, Cancer Research, Cell, Mice, chemistry.chemical_compound, 0302 clinical medicine, Molecular Targeted Therapy, biology, Liver Neoplasms, General Medicine, Sorafenib, medicine.anatomical_structure, Fibroblast growth factor receptor, 030220 oncology & carcinogenesis, Neoplastic Stem Cells, Quinolines, Female, Fibroblast Growth Factor 2, Fluorouracil, Lenvatinib, Signal Transduction, medicine.drug, Carcinoma, Hepatocellular, 03 medical and health sciences, Cell Line, Tumor, medicine, Animals, Humans, Receptor, Fibroblast Growth Factor, Type 3, Receptor, Fibroblast Growth Factor, Type 4, Receptor, Fibroblast Growth Factor, Type 1, Receptor, Fibroblast Growth Factor, Type 2, Protein Kinase Inhibitors, neoplasms, business.industry, Phenylurea Compounds, Fibroblast growth factor receptor 1, CD44, Cancer, Fibroblast growth factor receptor 4, medicine.disease, Xenograft Model Antitumor Assays, digestive system diseases, Fibroblast Growth Factors, 030104 developmental biology, chemistry, Cancer research, biology.protein, business
Abstract: In hepatocellular carcinoma (HCC), a subset of cells defined by high CD44 and CD133 expression has been reported to possess cancer stem-like cell (CSC) characteristics and to be associated with a poor prognosis. Since the approval of the multikinase inhibitor, lenvatinib, for patients with unresectable HCC, two such inhibitors (sorafenib and lenvatinib) have been employed as first-line systemic chemotherapeutics for these patients. Based on differences in the kinase-affinity profiles between these two drugs, evidence has suggested that both exert different effects on HCC, although these differences are not fully characterized. In this study, using in vitro and a preclinical in vivo xenograft mouse model, we showed that lenvatinib alone (not sorafenib or the cytotoxic agent, 5-fluorouracil) diminished CD44High/CD133High CSCs in HCC. Furthermore, western blotting and reverse transcriptase-polymerase chain reaction analysis revealed that the expression of fibroblast growth factor receptor (FGFR)-1–4 differed between CD44High/CD133High CSCs and control cells. Analysis of the effects of selective FGFR inhibitors and FGFR small interfering RNAs on CSCs in HCC revealed that lenvatinib diminished CSCs in HCC by inhibiting FGFR1–3 signaling, however, FGFR4 signaling was not impacted. Finally, we showed that FGF2 and FGF19 were involved in maintaining CD44High/CD133High CSCs in HCC, potentially, via FGFR1–3. The findings provide novel mechanistic insights into the effects of lenvatinib on CSCs in HCC and provide clues for developing effective targeted therapies against CSCs in HCC.
Published: 2020

90. Effects of ipragliflozin on the development and progression of kidney disease in patients with type 2 diabetes: An analysis from a multicenter prospective intervention study

Author: Akira Kanamori, Masahiro Takihata, Kotaro Iemitsu, Hikaru Amemiya, Mizuki Kaneshiro, Yoko Matsuzawa, Masashi Ishikawa, Keiji Tanaka, Hiroshi Takeda, Kazuaki Shinoda, Akira Kubota, Takehiro Kawata, Tetsuo Takuma, Nobuaki Minami, Yasushi Tanaka, Hideo Machimura, Ikuro Matsuba, Atsuko Mokubo, Masaaki Miyakawa, Masahiko Takai, Yasuo Terauchi, Syogo Ito, Taro Asakura, and Fuyuki Minagawa
Subjects: Blood Glucose, Male, Sodium–glucose cotransporter 2 inhibitor, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Urology, Renal function, 030209 endocrinology & metabolism, Thiophenes, Diabetic nephropathy, Type 2 diabetes, 030204 cardiovascular system & hematology, Diseases of the endocrine glands. Clinical endocrinology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Glucosides, Diabetes mellitus, Internal Medicine, medicine, Humans, Diabetic Nephropathies, Prospective Studies, Renal Insufficiency, Chronic, Adverse effect, Sodium-Glucose Transporter 2 Inhibitors, Aged, Glycemic, Glycated Hemoglobin, business.industry, Articles, General Medicine, Middle Aged, Prognosis, RC648-665, medicine.disease, Clinical Science and Care, Ipragliflozin, Diabetes Mellitus, Type 2, chemistry, Original Article, Female, business, Biomarkers, Follow-Up Studies, Glomerular Filtration Rate, Kidney disease
Abstract: Aims/Introduction Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long‐term treatments are available. Methods This was an investigator‐initiated multicenter prospective intervention study in which ipragliflozin (50 mg) was administered once daily, and glycemic control, estimated glomerular filtration rate (eGFR) and adverse events were evaluated until 104 weeks after starting research. Results There were 407 patients analyzed. In the eGFR ≥90 group and eGFR ≥60 to 300 group and the eGFR, In the estimated glomerular filtration rate (eGFR) ≥90 group and eGFR ≥60 to
Published: 2020

91. Canagliflozin Increases Calorie Intake in Type 2 Diabetes Without Changing the Energy Ratio of the Three Macronutrients: CANA-K Study

Author: Atsuko Mokubo, Masahiko Takai, Mizuki Kaneshiro, Takehiro Kawata, Akira Kanamori, Yasushi Tanaka, Tetsuo Takuma, Ikuro Matsuba, Akira Kubota, Mitsuo Obana, Shinichi Umezawa, Taisuke Kikuchi, Hideo Machimura, Hiroshi Takeda, Yoko Matsuzawa, Tetsuya Motomiya, Masahiro Takihata, Kotaro Iemitsu, Hajime Maeda, Masaaki Miyakawa, Shogo Ito, Yasuo Terauchi, and Taro Asakura
Subjects: Male, Glycosuria, Food intake, Endocrinology, Diabetes and Metabolism, Sodium, chemistry.chemical_element, 030209 endocrinology & metabolism, Type 2 diabetes, Diet Surveys, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Animal science, Diabetes mellitus, Weight Loss, Dietary Carbohydrates, medicine, Humans, Hypoglycemic Agents, Insulin, Prospective Studies, 030212 general & internal medicine, Canagliflozin, Sodium-Glucose Transporter 2 Inhibitors, Aged, Glycemic, Glycated Hemoglobin, business.industry, Nutrients, Middle Aged, medicine.disease, Dietary Fats, Calorie intake, Medical Laboratory Technology, Diabetes Mellitus, Type 2, chemistry, Female, Dietary Proteins, medicine.symptom, Energy Intake, Energy Metabolism, business, medicine.drug
Abstract: Background: Sodium/glucose cotransporter-2 (SGLT2) inhibitors improve glycemic control and reduce body weight by increasing glycosuria. Although a compensatory increase of food intake has been repo...
Published: 2020

92. Preclinical investigation of potential use of thymidine phosphorylase-targeting tracer for diagnosis of nonalcoholic steatohepatitis

Author: Hiroshi Takeda, Sawako Horiguchi, Yuji Kuge, Kazue Ohkura, Makoto Tarisawa, Yuki Shibata, Kei Higashikawa, and Hironobu Yasui
Subjects: Male, Nonalcoholic steatohepatitis, Cancer Research, Single Photon Emission Computed Tomography Computed Tomography, TYMP, digestive system, Imaging, 030218 nuclear medicine & medical imaging, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Western blot, Non-alcoholic Fatty Liver Disease, medicine, Animals, Tissue Distribution, Radiology, Nuclear Medicine and imaging, Radioactive Tracers, Thymidine phosphorylase, Uracil, Thymidine Phosphorylase, Messenger RNA, Methionine, medicine.diagnostic_test, business.industry, IIMU, NASH, nutritional and metabolic diseases, digestive system diseases, Mice, Inbred C57BL, Liver, chemistry, 030220 oncology & carcinogenesis, Liver biopsy, Cancer research, Autoradiography, Molecular Medicine, Immunohistochemistry, business
Abstract: Introduction: Although liver biopsy is the gold standard for the diagnosis of nonalcoholic steatohepatitis (NASH), it has several problems including high invasiveness and sampling errors. Therefore, the development of alternative methods to overcome these disadvantages is strongly required. In this study, we evaluated the potential use of our tracer targeting thymidine phosphorylase (TYMP),5-[I-123]iodo-6-[(2-iminoimidazolidinyl)methylluracil ([I-123]IIMU) for the diagnosis of NASH. Methods: The mice used as the NASH model (hereafter, NASH mice) were prepared by feeding a methionine- and choline-deficient diet for 4 weeks. A control group was similarly given a control diet. The expression levels of the TYMP gene and protein in the liver were examined by real-time reverse-transcription polymerase chain reaction and western blot analyses. The localizations of [I-125]IIMU and the TYMP protein in the liver were examined by autoradiography and immunohistochemical staining, respectively. Finally, the mice were injected with [I-123] IIMU and single-photon emission tomography (SPECT) imaging was conducted. Results: The hepatic expression levels of TYMP were significantly lower in the NASH mice than in the control mice at both mRNA and protein levels, suggesting that a decrease in TYMP level could be an indicator of NASH. [I-125] IIMU was uniformly distributed in the liver of the control mice, whereas it showed a patchy distribution in that of the NASH mice. The localization of [ I-125]IIMU was visually consistent with that of the TYMP protein in the liver of the control and NASH mice. SPECT analysis indicated that the hepatic accumulation of [I-123]IIMU in the NASH mice was significantly lower than that in the control mice ISUV (g/ml): 4.14 +/- 0.87 (Control) vs 2.31 = 029 (NASH)]. Conclusions: [I-12(3)]IIMU may provide a noninvasive means for imaging TYMP expression in the liver and may be applicable to the diagnosis of NASH. (C) 2019 Published by Elsevier Inc.
Published: 2020

93. A case of invasive pulmonary aspergillosis diagnosed by transbronchial lung biopsy during treatment for diabetic ketoacidosis in a type 1 diabetic patient

Author: Yumie Yamanaka, Ayu Kiritani, Chiaki Hosoda, Yoshitaka Seki, Kazuyoshi Kuwano, Naoaki Watanabe, Shota Fujimoto, Keisuke Saito, Ikumi Fujisaki, Hiroshi Takeda, Yasuhiko Endo, Akira Kinoshita, and Hanae Miyagawa
Subjects: 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, Diabetic ketoacidosis, Combination therapy, 030106 microbiology, Malignancy, 03 medical and health sciences, 0302 clinical medicine, Bronchoscopy, Internal medicine, medicine, Pharmacology (medical), 030212 general & internal medicine, skin and connective tissue diseases, Voriconazole, Type 1 diabetes, medicine.diagnostic_test, business.industry, Micafungin, Cancer, bacterial infections and mycoses, medicine.disease, respiratory tract diseases, Infectious Diseases, business, medicine.drug
Abstract: Invasive pulmonary aspergillosis (IPA) patients with non-hematological malignancy are far less than with hematological malignancy patients. We encountered a very rare case of IPA in which type 1 diabetes was the only conceivable risk factor. Further, according to the diagnostic categories of the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) criteria for IPA, the frequency of proven diagnosis is very low. Here we report a proven IPA, which rapidly developed when the patient with type 1 diabetes was being treated for diabetic ketoacidosis, which was successfully treated with the combination therapy of voriconazole (VRCZ) and micafungin (MCFG), based on early diagnosis using bronchoscopy.
Published: 2020

94. A Study of Seasonal Variation in the Effect of Add-On Sitagliptin on Blood Glucose Control in Insulin-Treated Patients With Type 2 Diabetes

Author: Akira Kanamori, Tetsuya Motomiya, Masahiko Takai, Hiroshi Takeda, Kotaro Iemitsu, Atsuko Mokubo, Hajime Maeda, Fuyuki Minagawa, Akira Kubota, Masashi Ishikawa, Takehiro Kawata, Tetsuo Takuma, Shinichi Umezawa, Keiji Tanaka, Hideo Machimura, and Ikuro Matsuba
Subjects: Seasonal effect, medicine.medical_specialty, HbA1c, endocrine system diseases, Glucose control, medicine.medical_treatment, 030209 endocrinology & metabolism, Type 2 diabetes, Dipeptidyl peptidase-4 inhibitor, 030204 cardiovascular system & hematology, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Sitagliptin, Medicine, In patient, business.industry, Insulin, General Medicine, Seasonality, medicine.disease, Original Article, Hemoglobin, business, medicine.drug
Abstract: Background: There are several reports of seasonal variation in hemoglobin A1c (HbA1c) in patients with type 2 diabetes (T2DM), but no reports of seasonal variation in the effect of add-on drugs on blood glucose control in insulin-treated patients. Methods: Using data collected from 630 patients in a multicenter study, we compared the amount of change in HbA1c after 1, 3, 6, 9, and 12 months of add-on administration of sitagliptin in insulin-treated patients divided into four groups based on the month when sitagliptin was started. Results: A significantly larger decrease in HbA1c at 6 months from baseline was observed in the group that started add-on sitagliptin in February to April than in the other three groups. However, the amount of change in HbA1c at 12 months did not differ among the groups. Conclusions: The consideration of seasonal variation enables more accurate evaluation of a drug’s short-term effect on blood glucose control. J Clin Med Res. 2020;12(3):200-208 doi: https://doi.org/10.14740/jocmr4103
Published: 2020

95. Uniform Energy Decay for Wave Equations with Unbounded Damping Coefficients

Author: Hiroshi Takeda and Ryo Ikehata
Subjects: Cauchy problem, Algebra and Number Theory, Weak solution, Mathematical analysis, Wave equation, Space (mathematics), symbols.namesake, Mathematics - Analysis of PDEs, Compact space, Fourier analysis, FOS: Mathematics, symbols, Initial value problem, 35L05, 35B35, 35B40, Geometry and Topology, Analysis, Energy (signal processing), Analysis of PDEs (math.AP), Mathematics
Abstract: We consider the Cauchy problem for wave equations with unbounded damping coefficients in the whole space. For a general class of unbounded damping coefficients, we derive uniform total energy decay estimates together with a unique existence result of a weak solution. In this case we never impose strong assumptions such as compactness of the support of the initial data. This means that we never rely on the finite propagation speed property of the solution, and we try to deal with an essential unbounded coefficient case., 15 pages
Published: 2020

96. The potential of soluble CD14 in discriminating nonalcoholic steatohepatitis from nonalcoholic fatty liver disease

Author: Akihisa Nakamura, Koji Yamamoto, Rei Takeda, Ren Yamada, Akinori Kubo, Kenichi Morikawa, Sayaka Ando, Tomoe Shimazaki, Takaaki Izumi, Machiko Umemura, Takashi Kitagataya, Taku Shigesawa, Kazuharu Suzuki, Megumi Kimura, Masato Nakai, Takuya Sho, Goki Suda, Mitsuteru Natsuizaka, Koji Ogawa, Shunsuke Ohnishi, Toshiro Sugiyama, Hiroshi Takeda, and Naoya Sakamoto
Subjects: Infectious Diseases, Hepatology
Abstract: Although various noninvasive markers and prediction formulas for nonalcoholic steatohepatitis (NASH) have been reported, they are of value only in the diagnosis of the advanced fibrosis stage of NASH. In this study, we evaluated soluble CD14 (sCD14) as a diagnostic marker for discriminating NASH from nonalcoholic fatty liver disease (NAFLD) using an animal model and clinical specimens.Serum sCD14 levels were measured in samples derived from mice with diet-induced NASH and patients using an enzyme-linked immunosorbent assay. Our cohort enrolled 126 patients with liver needle biopsy-proven NAFLD.The intestinal defense mechanism in NASH model mice was altered as a consequence of the unique gut environment. Elevated serum levels of sCD14 were observed in mice with diet-induced NASH, and the condition of the liver was exacerbated as a result of exposure to gut-derived endotoxin. We confirmed that the serum sCD14 levels in NAFL patients significantly differed from those in NASH patients. The area under the curve for distinguishing between NAFL and NASH was 0.891. Moreover, we found that serum sCD14 levels were weakly correlated with the inflammation grade based on the NAFLD activity score (NAS), the grade of fibrosis according to the Brunt fibrosis classification, and a positive correlation with the grade of ballooning based on NAS in patients with NAFLD.sCD14 could be a useful pathophysiological marker and diagnostic adjunct distinguishing NASH from NAFLD. The use of sCD14 may allow the screening and identification of high-risk groups for NASH development and support early therapeutic interventions.
Published: 2022

97. Functional Evaluation of Telemedicine with Super High Definition Images and B-ISDN.

Author: Hiroshi Takeda, Yasushi Matsumura, Takeo Okada, Shigeki Kuwata, Masaru Komori, Takashi Takahashi, Kotaro Minato, Tsutomu Hashimoto, Minoru Wada, and Yoshio Fujio
Published: 1998
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98. Devices for Structured Data Entry in Electronic Patient Record.

Author: Yasushi Matsumura, Hiroshi Takeda, Takeo Okada, Shigeki Kuwata, Hiroaki Nakazawa, Norihiro Hazumi, and Michitoshi Inoue
Published: 1998
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99. Information Systems and Patient Safety: Reaping the Benefits.

Author: Hiroshi Takeda, Satoko Tsuru, Elizabeth M. Borycki, and Peter J. Murray
Published: 2012

100. A PA-RISC Mikroprocessor PA/50L For Low-Cost Systems.

Author: Tetsuhiko Okada, Susumu Narita, Osamu Nishii, Noriharu Hiratsuka, Nobuyuki Hayashi, Mitsuo Asai, Shinji Fujiwara, Mikiko Satoh, Junichi Nishimoto, Hirokazu Aoki, Kunio Uchiyama, Shigeru Matsuo, Hidehito Takewa, Kouji Yamada, Masahiro Kainaga, Norio Nakagawa, Masanobu Yamagami, Hiroshi Takeda, and Tsuneo Funabashi
Published: 1994
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