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52. P2‐101: Aβ/PHOSPHO TAU LOAD IN CSF IS RELATED TO CORTICAL EXCITABILITY AS REVEALED BY CORTICAL EEG BIOMARKERS IN PATIENTS WITH PRODROMAL ALZHEIMER'S DISEASE: THE PHARMACOG PROJECT

Author

Babiloni, Claudio, primary, Del Percio, Claudio, additional, Marzano, Nicola, additional, Cordone, Susanna, additional, Lopez, Susanna, additional, Noce, Giuseppe, additional, Bagnoli, Cristina, additional, Rossini, Paolo, additional, Soricelli, Andrea, additional, Nobili, Flavio Mariano, additional, Bartrés-Faz, David, additional, Blin, Olivier, additional, Payoux, Pierre, additional, Bordet, Régis, additional, Mueller, Bernhard, additional, Tsolaki, Magda, additional, Parnetti, Lucilla, additional, Hegerl, Ulrich, additional, Hensch, Tilman, additional, Dukart, Juergen, additional, Bartolino, Alessandro, additional, Forloni, Gianluigi, additional, Frasca, Angelisa, additional, Richardson, Jill, additional, Bastlund, Jesper F., additional, Clausen, Bettina, additional, Bentivoglio, Marina, additional, Fabene, Paolo Francesco, additional, Bertini, Giuseppe, additional, Kelley, Jonathan, additional, Drinkenburg, Wilhelmus (Pim), additional, and Frisoni, Giovanni B., additional

Published
2018
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53. IC‐P‐126: VOLUMETRIC ACCURACY OF A FULLY AUTOMATIC TOOL FOR WHITE MATTER HYPERINTENSITIES (WMHS) SEGMENTATION

Author

Ribaldi, Federica, primary, Jovicich, Jorge, additional, Ferrari, Clarissa, additional, Bosch, Beatriz, additional, Bartrés-Faz, David, additional, Müller, Bernhard W., additional, Wiltfang, Jens, additional, Fiedler, Ute, additional, Montalti, Martina, additional, Roccatagliata, Luca, additional, Picco, Agnese, additional, Nobili, Flavio, additional, Blin, Olivier, additional, Bombois, Stephanie, additional, Lopes, Renaud, additional, Bordet, Régis, additional, Sein, Julien, additional, Ranjeva, Jean-Philippe, additional, Didic, Mira, additional, Gros-Dagnac, Helene, additional, Payoux, Pierre, additional, Alessandrini, Franco, additional, Beltramello, Alberto, additional, Bargallo, Núria, additional, Ferretti, Antonio, additional, Caulo, Massimo, additional, Aiello, Marco, additional, Cavaliere, Carlo, additional, Soricelli, Andrea, additional, Parnetti, Lucilla, additional, Tarducci, Robertto, additional, Floridi, Piero, additional, Tsolaki, Magda, additional, Constantinides, Manos, additional, Drevelegas, Antonios, additional, Rossini, Paolo, additional, Marra, Camillo, additional, Schonknecht, Peter, additional, Hensch, Tilman, additional, Hoffmann, Karl-Titus, additional, Kuijer, Joost, additional, Visser, Pieter Jelle, additional, Barkhof, Frederik, additional, Frisoni, Giovanni B., additional, and Marizzoni, Moira, additional

Published
2018
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55. CSF Beta-Amyloid and APOE E4 Related Decline in Episodic Memory over 12 months measured using the CANTAB in individuals with amnestic MCI: Results from the European-ADNI study

Author

Nathan, Pradeep J., Abbott, Rosemary, Lim, Yen Ying, Galluzzi, Samantha, Marizzoni, Moira, Bagnoli, Cristina, Babiloni, Claudio, Bartres-Faz, David, Bordet, Regis, Didic, Mira, Farotti, Lucia, Forloni, Gianluigi, Jovicich, Jorge, Marra, Camillo, Molinuevo, Jose Luis, Nobili, Flavio, Pariente, Jeremie, Parnetti, Lucilla, Payoux, Pierre, Ranjeva, Jean-Philippe, Rossini, Paolo Maria, Schonknecht, Peter, Hensch, Tilman, Soricelli, Andrea, Tsolaki, Magda, Pieter Jelle Visser, Wiltfang, Jens, Blin, Olivier, Frisoni, Giovanni B., Neurology, and Amsterdam Neuroscience - Neurodegeneration

Published
2016

57. [IC-P-167]: ACROSS-SESSION REPRODUCIBILITY OF AUTOMATIC WHITE MATTER HYPERINTENSITIES SEGMENTATION: A EUROPEAN MULTI-SITE 3T STUDY

Author

Ribaldi, Federica, primary, Marizzoni, Moira, additional, Jovicich, Jorge, additional, Ferrari, Clarissa, additional, Bosch, Beatriz, additional, Bartrés-Faz, David, additional, Müller, Bernhard W., additional, Wiltfang, Jens, additional, Fiedler, Ute, additional, Roccatagliata, Luca, additional, Picco, Agnese, additional, Nobili, Flavio, additional, Blin, Olivier, additional, Bombois, Stephanie, additional, Lopes, Renaud, additional, Bordet, Regis, additional, Sein, Julien, additional, Ranjeva, Jean-Philippe, additional, Didic, Mira, additional, Gros-Dagnac, Helene, additional, Payoux, Pierre, additional, Zoccatelli, Giada, additional, Alessandrini, Franco, additional, Beltramello, Alberto, additional, Bargalló, Nuria, additional, Ferretti, Antonio, additional, Caulo, Massimo, additional, Aiello, Marco, additional, Cavaliere, Carlo, additional, Soricelli, Andrea, additional, Parnetti, Lucilla, additional, Tarducci, Robertto, additional, Floridi, Piero, additional, Tsolaki, Magda, additional, Constantinides, Manos, additional, Drevelegas, Antonios, additional, Rossini, Paolo Maria, additional, Marra, Camillo, additional, Schonknecht, Peter, additional, Hensch, Tilman, additional, Hoffmann, Karl-Titus, additional, Kuijer, Joost, additional, Visser, Pieter Jelle, additional, Barkhof, Frederik, additional, and Frisoni, Giovanni B., additional

Published
2017
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58. [P4–160]: BACK‐TRANSLATION OF EEG/ERP MARKERS FROM AMNESTIC MCI PATIENTS TO HEALTHY YOUNG VOLUNTEERS IN THE PHARMACOG PROJECT

Author

Cordone, Susanna, primary, Babiloni, Claudio, additional, Del Percio, Claudio, additional, Noce, Giuseppe, additional, Marizzoni, Moira, additional, Rossini, Paolo Maria, additional, Soricelli, Andrea, additional, Nobili, Flavio, additional, Bartrés‐Faz, David, additional, Blin, Olivier, additional, Payoux, Pierre, additional, Bordet, Regis, additional, Mueller, Bernhard, additional, Tsolaki, Magda, additional, Parnetti, Lucilla, additional, Hegerl, Ulrich, additional, Hensch, Tilman, additional, Dukart, Juergen, additional, Forloni, Gianluigi, additional, Lanteaume, Laura, additional, Richardson, Jill, additional, and Frisoni, Giovanni B., additional

Published
2017
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59. ACROSS-SESSION REPRODUCIBILITY OF AUTOMATIC WHITE MATTER HYPERINTENSITIES SEGMENTATION: A EUROPEAN MULTI-SITE 3T STUDY

Author

Ribaldi, Federica, primary, Marizzoni, Moira, additional, Jovicich, Jorge, additional, Ferrari, Clarissa, additional, Bosch, Beatriz, additional, Bartrés-Faz, David, additional, Müller, Bernhard W., additional, Wiltfang, Jens, additional, Fiedler, Ute, additional, Roccatagliata, Luca, additional, Picco, Agnese, additional, Nobili, Flavio, additional, Blin, Olivier, additional, Bombois, Stephanie, additional, Lopes, Renaud, additional, Bordet, Regis, additional, Sein, Julien, additional, Ranjeva, Jean-Philippe, additional, Didic, Mira, additional, Gros-Dagnac, Helene, additional, Payoux, Pierre, additional, Zoccatelli, Giada, additional, Alessandrini, Franco, additional, Beltramello, Alberto, additional, Bargallo, Núria, additional, Ferretti, Antonio, additional, Caulo, Massimo, additional, Aiello, Marco, additional, Cavaliere, Carlo, additional, Soricelli, Andrea, additional, Parnetti, Lucilla, additional, Tarducci, Robertto, additional, Floridi, Piero, additional, Tsolaki, Magda, additional, Constantinides, Manos, additional, Drevelegas, Antonios, additional, Rossini, Paolo Maria, additional, Marra, Camillo, additional, Schonknecht, Peter, additional, Hensch, Tilman, additional, Hoffmann, Karl-Titus, additional, Kuijer, Joost, additional, Visser, Pieter Jelle, additional, Barkhof, Frederik, additional, and Frisoni, Giovanni B., additional

Published
2017
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62. The LIFE-Adult-Study: Objectives and design of a population-based cohort study with 10,000 deeply phenotyped adults in Germany

Author

Loeffler, Markus, Engel, Christoph, Ahnert, Peter, Alfermann, Dorothee, Arelin, Katrin, Baber, Ronny, Beutner, Frank, Binder, Hans, Brähler, Elmar, Burkhardt, Ralph, Ceglarek, Uta, Enzenbach, Cornelia, Fuchs, Michael, Glaesmer, Heide, Girlich, Friederike, Hagendorff, Andreas, Häntzsch, Madlen, Hegerl, Ulrich, Henger, Sylvia, Hensch, Tilman, Hinz, Andreas, Holzendorf, Volker, Husser, Daniela, Kersting, Anette, Kiel, Alexander, Kirsten, Toralf, Kratzsch, Jürgen, Krohn, Knut, Luck, Tobias, Melzer, Susanne, Netto, Jeffrey, Nüchter, Matthias, Raschpichler, Matthias, Rauscher, Franziska G., Riedel-Heller, Steffi G., Sander, Christian, Scholz, Markus, Schönknecht, Peter, Schroeter, Matthias L., Simon, Jan-Christoph, Speer, Ronald, Stäker, Julia, Stein, Robert, Stöbel-Richter, Yve, Stumvoll, Michael, Tarnok, Attila, Teren, Andrej, Teupser, Daniel, Then, Francisca S., Tönjes, Anke, Treudler, Regina, Villringer, Arno, Weissgerber, Alexander, Wiedemann, Peter, Zachariae, Silke, Wirkner, Kerstin, and Thiery, Joachim

Subjects
Adult, Male, Population based, Urban Population, Epidemiology, Diseases of civilization, Health Status, Public Health, Environmental and Occupational Health, Middle Aged, Health Surveys, Cohort Studies, Study Protocol, Research Design, Germany, Population Surveillance, Health Status Indicators, Humans, Female, Cohort study, Physical Examination, Aged
Abstract

BACKGROUND: The LIFE-Adult-Study is a population-based cohort study, which has recently completed the baseline examination of 10,000 randomly selected participants from Leipzig, a major city with 550,000 inhabitants in the east of Germany. It is the first study of this kind and size in an urban population in the eastern part of Germany. The study is conducted by the Leipzig Research Centre for Civilization Diseases (LIFE). Our objective is to investigate prevalences, early onset markers, genetic predispositions, and the role of lifestyle factors of major civilization diseases, with primary focus on metabolic and vascular diseases, heart function, cognitive impairment, brain function, depression, sleep disorders and vigilance dysregulation, retinal and optic nerve degeneration, and allergies. METHODS/DESIGN: The study covers a main age range from 40-79 years with particular deep phenotyping in elderly participants above the age of 60. The baseline examination was conducted from August 2011 to November 2014. All participants underwent an extensive core assessment programme (5-6 h) including structured interviews, questionnaires, physical examinations, and biospecimen collection. Participants over 60 underwent two additional assessment programmes (3-4 h each) on two separate visits including deeper cognitive testing, brain magnetic resonance imaging, diagnostic interviews for depression, and electroencephalography. DISCUSSION: The participation rate was 33 %. The assessment programme was accepted well and completely passed by almost all participants. Biomarker analyses have already been performed in all participants. Genotype, transcriptome and metabolome analyses have been conducted in subgroups. The first follow-up examination will commence in 2016.

Published
2015

63. Two-Year Longitudinal Monitoring of Amnestic Mild Cognitive Impairment Patients with Prodromal Alzheimer's Disease Using Topographical Biomarkers Derived from Functional Magnetic Resonance Imaging and Electroencephalographic Activity.

Author

Jovicich, Jorge, Babiloni, Claudio, Ferrari, Clarissa, Marizzoni, Moira, Moretti, Davide V., Del Percio, Claudio, Lizio, Roberta, Lopez, Susanna, Galluzzi, Samantha, Albani, Diego, Cavaliere, Libera, Minati, Ludovico, Didic, Mira, Fiedler, Ute, Forloni, Gianluigi, Hensch, Tilman, Molinuevo, José Luis, Bartrés Faz, David, Nobili, Flavio, and Orlandi, Daniele

Subjects
FUNCTIONAL magnetic resonance imaging, AMNESTIC mild cognitive impairment, ALZHEIMER'S patients, MILD cognitive impairment, BIOMARKERS
Abstract

Auditory "oddball" event-related potentials (aoERPs), resting state functional magnetic resonance imaging (rsfMRI) connectivity, and electroencephalographic (rsEEG) rhythms were tested as longitudinal functional biomarkers of prodromal Alzheimer's disease (AD). Data were collected at baseline and four follow-ups at 6, 12, 18, and 24 months in amnesic mild cognitive impairment (aMCI) patients classified in two groups: "positive" (i.e., "prodromal AD"; n = 81) or "negative" (n = 63) based on a diagnostic marker of AD derived from cerebrospinal samples (Aβ42/P-tau ratio). A linear mixed model design was used to test functional biomarkers for Group, Time, and Group×Time effects adjusted by nuisance covariates (only data until conversion to dementia was used). Functional biomarkers that showed significant Group effects ("positive" versus "negative", p < 0.05) regardless of Time were 1) reduced rsfMRI connectivity in both the default mode network (DMN) and the posterior cingulate cortex (PCC), both also giving significant Time effects (connectivity decay regardless of Group); 2) increased rsEEG source activity at delta (<4 Hz) and theta (4-8 Hz) rhythms and decreased source activity at low-frequency alpha (8-10.5 Hz) rhythms; and 3) reduced parietal and posterior cingulate source activities of aoERPs. Time×Group effects showed differential functional biomarker progression between groups: 1) increased rsfMRI connectivity in the left parietal cortex of the DMN nodes, consistent with compensatory effects and 2) increased limbic source activity at theta rhythms. These findings represent the first longitudinal characterization of functional biomarkers of prodromal AD relative to "negative" aMCI patients based on 5 serial recording sessions over 2 years. [ABSTRACT FROM AUTHOR]

Published
2019
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64. Predicting and Tracking Short Term Disease Progression in Amnestic Mild Cognitive Impairment Patients with Prodromal Alzheimer's Disease: Structural Brain Biomarkers.

Author

Marizzoni, Moira, Ferrari, Clarissa, Jovicich, Jorge, Albani, Diego, Babiloni, Claudio, Cavaliere, Libera, Didic, Mira, Forloni, Gianluigi, Galluzzi, Samantha, Hoffmann, Karl-Titus, Molinuevo, José Luis, Nobili, Flavio, Parnetti, Lucilla, Payoux, Pierre, Ribaldi, Federica, Rossini, Paolo Maria, Schönknecht, Peter, Salvatore, Marco, Soricelli, Andrea, and Hensch, Tilman

Subjects
AMNESTIC mild cognitive impairment, ALZHEIMER'S patients, BRAIN diseases, DISEASE progression, GRANULE cells
Abstract

Background: Early Alzheimer's disease (AD) detection using cerebrospinal fluid (CSF) biomarkers has been recommended as enrichment strategy for trials involving mild cognitive impairment (MCI) patients.Objective: To model a prodromal AD trial for identifying MRI structural biomarkers to improve subject selection and to be used as surrogate outcomes of disease progression.Methods: APOE ɛ4 specific CSF Aβ42/P-tau cut-offs were used to identify MCI with prodromal AD (Aβ42/P-tau positive) in the WP5-PharmaCog (E-ADNI) cohort. Linear mixed models were performed 1) with baseline structural biomarker, time, and biomarker×time interaction as factors to predict longitudinal changes in ADAS-cog13, 2) with Aβ42/P-tau status, time, and Aβ42/P-tau status×time interaction as factors to explain the longitudinal changes in MRI measures, and 3) to compute sample size estimation for a trial implemented with the selected biomarkers.Results: Only baseline lateral ventricle volume was able to identify a subgroup of prodromal AD patients who declined faster (interaction, p = 0.003). Lateral ventricle volume and medial temporal lobe measures were the biomarkers most sensitive to disease progression (interaction, p≤0.042). Enrichment through ventricular volume reduced the sample size that a clinical trial would require from 13 to 76%, depending on structural outcome variable. The biomarker needing the lowest sample size was the hippocampal subfield GC-ML-DG (granule cells of molecular layer of the dentate gyrus) (n = 82 per arm to demonstrate a 20% atrophy reduction).Conclusion: MRI structural biomarkers can enrich prodromal AD with fast progressors and significantly decrease group size in clinical trials of disease modifying drugs. [ABSTRACT FROM AUTHOR]

Published
2019
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65. PT593. CSF Beta-Amyloid and APOE E4 Related Decline in Episodic Memory over 12 months measured using the CANTAB in individuals with amnestic MCI: Results from the European-ADNI study

Author

Nathan, Pradeep J., Abbott, Rosemary, Lim, Yen Ying, Galluzzi, Samantha, Marizzoni, Moira, Bagnoli, Cristina, Babiloni, Claudio, David, Bartres-Faz, Bordet, Regis, Didic, Mira, Farotti, Lucia, Forloni, Gianluigi, Jovicich, Jorge, Marra, Camillo, José, Luis Molinuevo, Nobili, Flavio, Pariente, Jeremie, Parnetti, Lucilla, Payoux, Pierre, Ranjeva, Jean-Philippe, Rossini, Paolo Maria, Schonknecht, Peter, Hensch, Tilman, Soricelli, Andrea, Tsolaki, Magda, Visser, Pieter Jelle, Wiltfang, Jens, Blin, Olivier, and Frisoni, Giovanni B.

Subjects
Pharmacology, Abstracts, Tuesday Abstracts, Psychiatry and Mental health, Pharmacology (medical)
Published
2016
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66. Genetic Association of Objective Sleep Phenotypes with a Functional Polymorphism in the Neuropeptide S Receptor Gene

Author

Spada, Janek, Sander, Christian, Burkhardt, Ralph, Häntzsch, Madlen, Mergl, Roland, Scholz, Markus, Hegerl, Ulrich, Hensch, Tilman, and Universität Leipzig

Subjects
Male, Genotype, Physiology, Science, Pathology and Laboratory Medicine, Biochemistry, Polymorphism, Single Nucleotide, Receptors, G-Protein-Coupled, Diagnostic Medicine, Mental Health and Psychiatry, Genetics, Medicine and Health Sciences, Psychology, Humans, ddc:610, Genetic Association Studies, Alleles, Aged, Evolutionary Biology, Schlafstörungen, ältere Personen, Neuropeptide, Nucleus arcuatus, Polymorphism, Genetic, Neuromodulation, Age Factors, Biology and Life Sciences, Neurochemistry, Human Genetics, Middle Aged, Phenotype, Neurology, Genetic Polymorphism, Medicine, Sleep disorders, Elderly, Neuropeptides, Arcuate nucleus, Female, Physiological Processes, Sleep, Sleep Disorders, Biomarkers, Population Genetics, Research Article, Neuroscience
Abstract

Background: The neuropeptide S receptor (NPSR1) and its ligand neuropeptide S (NPS) have received increased attention in the last few years, as both establish a previously unknown system of neuromodulation. Animal research studies have suggested that NPS may be involved in arousal/wakefulness and may also have a crucial role in sleep regulation. The single nucleotide polymorphism (SNP) rs324981 in NPSR1 has begun to shed light on a function of the NPS-system in human sleep regulation. Due to an amino acid exchange, the T-allele leads to an increased sensitivity of the NPSR1. In the only genomewide association study to date on circadian sleep parameters in humans, an association was found between rs324981 and regular bedtime. However, the sleep parameters in this study were only measured by self-rating. Therefore, our study aimed to replicate these findings using an objective measure of sleep. Methods: The study included n = 393 white subjects (62–79 years) who participated in an actigraphic assessment for determining sleep duration, rest duration, sleep onset, rest onset and sleep onset latency. Genotyping of the SNP rs324981 was performed using the TaqMan OpenArray System. Results: The genotype at rs324981 was not significantly associated with rest onset (bedtime) or sleep onset (p = .146 and p = .199, respectively). However, the SNP showed a significant effect on sleep- and rest duration (p = .007 and p = .003, respectively). Subjects that were homozygous for the minor T-allele had a significantly decreased sleep- and rest duration compared to A-allele carriers. Conclusion: The results of this study indicate that the sleep pattern in humans is influenced by the NPS-system. However, the previously reported association between bedtime and rs324981 could not be confirmed. The current finding of decreased sleep duration in T/T allele carriers is in accordance with studies in rodents reporting similar results after NPS application.:Background; Methods; Results; Conclusions

Published
2014
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68. Sleep disturbances and upregulation of brain arousal during daytime in depressed versus non-depressed elderly subjects

Author

Ulke, Christine, primary, Sander, Christian, additional, Jawinski, Philippe, additional, Mauche, Nicole, additional, Huang, Jue, additional, Spada, Janek, additional, Wittekind, Dirk, additional, Mergl, Roland, additional, Luck, Tobias, additional, Riedel-Heller, Steffi, additional, Hensch, Tilman, additional, and Hegerl, Ulrich, additional

Published
2016
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70. P3-057: Association Between EEG/ERP and CSF Markers in Prodromal Alzheimer’s Disease in the Pharmacog Project

Author

Babiloni, Claudio, primary, Del Percio, Claudio, additional, Marzano, Nicola, additional, Cordone, Susanna, additional, Noce, Giuseppe, additional, Cavaliere, Libera, additional, Marizzoni, Moira, additional, Rossini, Paolo Maria, additional, Soricelli, Andrea, additional, Nobili, Flavio Mariano, additional, Bartres, David, additional, Blin, Olivier, additional, Payoux, Pierre, additional, Bordet, Regis, additional, Mueller, Bernhard, additional, Tsolaki, Magda, additional, Parnetti, Lucilla, additional, Hegerl, Ulrich, additional, Hensch, Tilman, additional, Dukart, Juergen, additional, Forloni, Gianluigi, additional, Richardson, Jill, additional, and Frisoni, Giovanni B., additional

Published
2016
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71. P3-056: Back-Translation of EEG/ERP Markers from Amnestic MCI Patients to Healthy Young Volunteers in the Pharmacog Project

Author

Babiloni, Claudio, primary, Del Percio, Claudio, additional, Marzano, Nicola, additional, Cordone, Susanna, additional, Noce, Giuseppe, additional, Marizzoni, Moira, additional, Rossini, Paolo Maria, additional, Soricelli, Andrea, additional, Nobili, Flavio Mariano, additional, Bartres, David, additional, Blin, Olivier, additional, Payoux, Pierre, additional, Bordet, Regis, additional, Mueller, Bernhard, additional, Tsolaki, Magda, additional, Parnetti, Lucilla, additional, Hegerl, Ulrich, additional, Hensch, Tilman, additional, Dukart, Juergen, additional, Bartolino, Alessandro, additional, Farotti, Lucia, additional, Salvadori, Nicola, additional, Forloni, Gianluigi, additional, Lanteaume, Laura, additional, Richardson, Jill, additional, and Frisoni, Giovanni B., additional

Published
2016
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72. P3-315: Differential Effects of Apoe and CSF Amyloid on Memory Impairment in Individuals with Amnestic MCI Using the Cantab Cognitive Battery: Results from the European-Adni Study

Author

Abbott, Rosemary A., primary, Nathan, Pradeep J., additional, Lim, Yen Ying, additional, Galluzzi, Samantha, additional, Marizzoni, Moira, additional, Bagnoli, Cristina, additional, Bartes-Faz, David, additional, Bordet, Regis, additional, Farotti, Lucia, additional, Forlini, Gianluigi, additional, Jovicich, Jorge, additional, Marra, Camillo, additional, Molinuevo, José Luis, additional, Nobili, Flavio, additional, Pariente, Jeremie, additional, Parnetti, Lucilla, additional, Payoux, Pierre, additional, Ranjeva, Jean-Philippe, additional, Rossini, Paolo Maria, additional, Schonknecht, Peter, additional, Hensch, Tilman, additional, Soricelli, Andrea, additional, Tsolaki, Magda, additional, Visser, Pieter Jelle, additional, Wiltgang, Jens, additional, Blin, Olivier, additional, and Frisoni, Giovanni B., additional

Published
2016
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73. P2-302: CSF Beta-Amyloid- and APOE Ɛ4-Related Decline in Episodic Memory Over 12 Months Measured using the Cantab in Individuals with Amnestic MCI: Results from the European ADNI Study

Author

Nathan, Pradeep J., primary, Abbott, Rosemary A., additional, Lim, Yen Ying, additional, Galluzzi, Samantha, additional, Marizzoni, Moira, additional, Bagnoli, Cristina, additional, Babiloni, Claudio, additional, Bartres-Faz, David, additional, Bordet, Regis, additional, Didic, Mira, additional, Farotti, Lucia, additional, Forloni, Gianluigi, additional, Jovicich, Jorge, additional, Marra, Camillo, additional, Molinuevo, Jose Luis, additional, Nobili, Flavio, additional, Pariente, Jeremie, additional, Parnetti, Lucilla, additional, Payoux, Pierre, additional, Ranjeva, Jean-Philippe, additional, Rossini, Paolo, additional, Schonknecht, Peter, additional, Hensch, Tilman, additional, Soricelli, Andrea, additional, Tsolaki, Magda, additional, Visser, Pieter Jelle, additional, Wiltfang, Jens, additional, Blin, Olivier, additional, and Frisoni, Giovanni B., additional

Published
2016
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74. Time to wake up: No impact of COMT Val158Met gene variation on circadian preferences, arousal regulation and sleep

Author

Jawinski, Philippe, primary, Tegelkamp, Sophie, additional, Sander, Christian, additional, Häntzsch, Madlen, additional, Huang, Jue, additional, Mauche, Nicole, additional, Scholz, Markus, additional, Spada, Janek, additional, Ulke, Christine, additional, Burkhardt, Ralph, additional, Reif, Andreas, additional, Hegerl, Ulrich, additional, and Hensch, Tilman, additional

Published
2016
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76. VOLUMETRIC ACCURACY OF A FULLY AUTOMATIC TOOL FOR WHITE MATTER HYPERINTENSITIES (WMHS) SEGMENTATION

Author

Ribaldi, Federica, Jovicich, Jorge, Ferrari, Clarissa, Bosch, Beatriz, Bartrés-Faz, David, Müller, Bernhard W., Wiltfang, Jens, Fiedler, Ute, Montalti, Martina, Roccatagliata, Luca, Picco, Agnese, Nobili, Flavio, Blin, Olivier, Bombois, Stephanie, Lopes, Renaud, Bordet, Régis, Sein, Julien, Ranjeva, Jean-Philippe, Didic, Mira, Gros-Dagnac, Helene, Payoux, Pierre, Alessandrini, Franco, Beltramello, Alberto, Bargallo, Núria, Ferretti, Antonio, Caulo, Massimo, Aiello, Marco, Cavaliere, Carlo, Soricelli, Andrea, Parnetti, Lucilla, Tarducci, Robertto, Floridi, Piero, Tsolaki, Magda, Constantinides, Manos, Drevelegas, Antonios, Rossini, Paolo, Marra, Camillo, Schonknecht, Peter, Hensch, Tilman, Hoffmann, Karl-Titus, Kuijer, Joost, Visser, Pieter Jelle, Barkhof, Frederik, Frisoni, Giovanni B., and Marizzoni, Moira

Published
2018
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77. Aβ/PHOSPHO TAU LOAD IN CSF IS RELATED TO CORTICAL EXCITABILITY AS REVEALED BY CORTICAL EEG BIOMARKERS IN PATIENTS WITH PRODROMAL ALZHEIMER'S DISEASE: THE PHARMACOG PROJECT

Author

Babiloni, Claudio, Del Percio, Claudio, Marzano, Nicola, Cordone, Susanna, Lopez, Susanna, Noce, Giuseppe, Bagnoli, Cristina, Rossini, Paolo, Soricelli, Andrea, Nobili, Flavio Mariano, Bartrés-Faz, David, Blin, Olivier, Payoux, Pierre, Bordet, Régis, Mueller, Bernhard, Tsolaki, Magda, Parnetti, Lucilla, Hegerl, Ulrich, Hensch, Tilman, Dukart, Juergen, Bartolino, Alessandro, Forloni, Gianluigi, Frasca, Angelisa, Richardson, Jill, Bastlund, Jesper F., Clausen, Bettina, Bentivoglio, Marina, Fabene, Paolo Francesco, Bertini, Giuseppe, Kelley, Jonathan, Drinkenburg, Wilhelmus (Pim), and Frisoni, Giovanni B.

Published
2018
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78. Disease tracking markers for Alzheimer's disease at the prodromal (MCI) stage

Author

Drago, Valeria, Babiloni, Claudio, Bartrés-Faz, David, Caroli, Anna, Bosch, Beatriz, Hensch, Tilman, Didic, Mira, Klafki, Hans-Wolfgang, Pievani, Michela, Jovicich, Jorge, Venturi, Luca, Spitzer, Philipp, Vecchio, Fabrizio, Schoenknecht, Peter, Wiltfang, Jans, Redolfi, Alberto, Forloni, Gianluigi, Blin, Olivier, Irving, Elaine, Davis, Ceri, Hrdemark, Hans-Goran, Frisoni, Giovanni B., and Hårdemark, Hans-goran

Subjects
Oncology, medicine.medical_specialty, Medizin, Neuroimaging, Disease, Electroencephalography, Neuropsychological Tests, Atrophy, Alzheimer Disease, Internal medicine, medicine, Dementia, Humans, Cognitive Dysfunction, Episodic memory, medicine.diagnostic_test, General Neuroscience, Prodromal Stage, Neuropsychology, Brain, Reproducibility of Results, cerebrospinal fluid/diagnosis/physiopathology, Atrophy, Biological Markers, cerebrospinal fluid, Brain, pathology, Cross-Sectional Studies, Disease Progression, Humans, Mild Cognitive Impairment, cerebrospinal fluid/physiopathology, Neuroimaging, methods, Neuropsychological Tests, Reproducibility of Results, General Medicine, medicine.disease, Psychiatry and Mental health, Clinical Psychology, Cross-Sectional Studies, Disease Progression, Geriatrics and Gerontology, Psychology, Neuroscience, Biomarkers
Abstract

Older persons with Mild Cognitive Impairment (MCI) feature neurobiological Alzheimer's Disease (AD) in 50% to 70% of the cases and develop dementia within the next 5 to 7 years. Current evidence suggests that biochemical, neuroimaging, electrophysiological, and neuropsychological markers can track the disease over time since the MCI stage (also called prodromal AD). The amount of evidence supporting their validity is of variable strength. We have reviewed the current literature and categorized evidence of validity into three classes: Class A, availability of multiple serial studies; Class B a single serial study or multiple cross sectional studies of patients with increasing disease severity from MCI to probable AD; and class C, multiple cross sectional studies of patients in the dementia stage, not including the MCI stage. Several Class A studies suggest that episodic memory and semantic fluency are the most reliable neuropsychological markers of progression. Hippocampal atrophy, ventricular volume and whole brain atrophy are structural MRI markers with class A evidence. Resting-state fMRI and connectivity, and diffusion MR markers in the medial temporal white matter (parahippocampus and posterior cingulum) and hippocampus are promising but require further validation. Change in amyloid load in MCI patients warrant further investigations, e.g. over longer period of time, to assess its value as marker of disease progression. Several spectral markers of resting state EEG rhythms that might reflect neurodegenerative processes in the prodromal stage of AD (EEG power density, functional coupling, spectral coherence, and synchronization) suffer from lack of appropriately designed studies. Although serial studies on late event-related potentials (ERPs) in healthy elders or MCI patients are inconclusive, others tracking disease progression and effects of cholinesterase inhibiting drugs in AD, and cross-sectional including MCI or predicting development of AD offer preliminary evidence of validity as a marker of disease progression from the MCI stage. CSF Markers, such as Aβ 1-42, t-tau and p-tau are valuable markers which support the clinical diagnosis of Alzheimer's disease. However, these markers are not sensitive to disease progression and cannot be used to monitor the severity of Alzheimer's disease. For Isoprostane F2 some evidence exists that its increase correlates with the progression and the severity of AD.

Published
2011

79. cover Disease Tracking Markers for Alzheimer's Disease at the Prodromal (MCI) Stage

Author

Drago, Valeria, Babiloni, Claudio, Bartrés-Faz, David, Caroli, Anna, Bosch, Beatriz, Hensch, Tilman, Didic, Mira, Klafki, Hans-Wolfgang, Pievani, Michela, Jovicich, Jorge, Venturi, Luca, Spitzer, Philipp, Vecchio, Fabrizio, Schoenknecht, Peter, Wiltfang, Jans, Redolfi, Alberto, Forloni, Gianluigi, Blin, Olivier, Irving, Elaine, Davis, Ceri, Hrdemark, Hans-Goran, and Frisoni, Giovanni B.

Subjects
Medizin
Published
2011

81. The LIFE-Adult-Study: objectives and design of a population-based cohort study with 10,000 deeply phenotyped adults in Germany

Author

Loeffler, Markus, primary, Engel, Christoph, additional, Ahnert, Peter, additional, Alfermann, Dorothee, additional, Arelin, Katrin, additional, Baber, Ronny, additional, Beutner, Frank, additional, Binder, Hans, additional, Brähler, Elmar, additional, Burkhardt, Ralph, additional, Ceglarek, Uta, additional, Enzenbach, Cornelia, additional, Fuchs, Michael, additional, Glaesmer, Heide, additional, Girlich, Friederike, additional, Hagendorff, Andreas, additional, Häntzsch, Madlen, additional, Hegerl, Ulrich, additional, Henger, Sylvia, additional, Hensch, Tilman, additional, Hinz, Andreas, additional, Holzendorf, Volker, additional, Husser, Daniela, additional, Kersting, Anette, additional, Kiel, Alexander, additional, Kirsten, Toralf, additional, Kratzsch, Jürgen, additional, Krohn, Knut, additional, Luck, Tobias, additional, Melzer, Susanne, additional, Netto, Jeffrey, additional, Nüchter, Matthias, additional, Raschpichler, Matthias, additional, Rauscher, Franziska G., additional, Riedel-Heller, Steffi G., additional, Sander, Christian, additional, Scholz, Markus, additional, Schönknecht, Peter, additional, Schroeter, Matthias L., additional, Simon, Jan-Christoph, additional, Speer, Ronald, additional, Stäker, Julia, additional, Stein, Robert, additional, Stöbel-Richter, Yve, additional, Stumvoll, Michael, additional, Tarnok, Attila, additional, Teren, Andrej, additional, Teupser, Daniel, additional, Then, Francisca S., additional, Tönjes, Anke, additional, Treudler, Regina, additional, Villringer, Arno, additional, Weissgerber, Alexander, additional, Wiedemann, Peter, additional, Zachariae, Silke, additional, Wirkner, Kerstin, additional, and Thiery, Joachim, additional

Published
2015
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82. P2‐176: Are cortical sources of auditory oddball event‐related potentials an early diagnostic marker of Alzheimer's disease?

Author

Babiloni, Claudio, primary, Del Percio, Claudio, additional, Marzano, Nicola, additional, Cordone, Susanna, additional, Noce, Giuseppe, additional, Bagnoli, Christina, additional, Rossini, Paolo Maria, additional, Soricelli, Andrea, additional, Nobili, Flavio, additional, Bartres, David, additional, Blin, Olivier, additional, Payoux, Pierre, additional, Bordet, Regis, additional, Muller, Bernhard W., additional, Tsolaki, Magda, additional, Parnetti, Lucilla, additional, Hegerl, Ulrich, additional, Hensch, Tilman, additional, Dukart, Juergen, additional, Bartolino, Alessandro, additional, Forloni, Gianluigi, additional, Richardson, Jill, additional, and Frisoni, Giovanni Battista, additional

Published
2015
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83. P2-188: Characterization of cognitive function with the cantab in individuals with amnestic mild cognitive impairment in relation to hippocampal volume, amyloid, and tau status: Preliminary baseline results from the PharmaCog/european-ADNI study

Author

Nathan, Pradeep J., primary, Galluzzi, Samantha, additional, Marizzoni, Moira, additional, Cotelli, Maria, additional, Babiloni, Claudio, additional, Bartres-Faz, David, additional, Bordet, Regis, additional, Bosch, Beatriz, additional, de Anna, Francesca, additional, Didic, Mira, additional, Farotti, Lucia, additional, Forloni, Gianluigi, additional, Jovicich, Jorge, additional, Marra, Camillo, additional, Marzano, Nicola, additional, Molinuevo, Jose Luis, additional, Nobili, Flavio, additional, Pariente, Jeremie, additional, Parnetti, Lucilla, additional, Payoux, Pierre, additional, Picco, Agnese, additional, Ranjeva, Jean-Philippe, additional, Roccatagliata, Luca, additional, Rossini, Paolo, additional, Salvadori, Nicola, additional, Schonknecht, Peter, additional, Berwig, Martin, additional, Hensch, Tilman, additional, Soricelli, Andrea, additional, Tsolaki, Magda, additional, Vecchio, Fabrizio, additional, Visser, Pieter Jelle, additional, Wiltfang, Jens, additional, Orlandi, Daniele, additional, Blackwell, Andrew, additional, Abbott, Rosemary A., additional, Blin, Olivier, additional, and Frisoni, Giovanni Battista, additional

Published
2015
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84. P2-175: Are cortical sources of resting state eyes-closed electroencephalographic rhythms an early diagnostic marker of Alzheimer's disease?

Author

Babiloni, Claudio, primary, Del Percio, Claudio, additional, Marzano, Nicola, additional, Cordone, Susanna, additional, Noce, Giuseppe, additional, Bagnoli, Christina, additional, Rossini, Paolo Maria, additional, Soricelli, Andrea, additional, Nobili, Flavio, additional, Bartres, David, additional, Blin, Olivier, additional, Payoux, Pierre, additional, Bordet, Regis, additional, Muller, Bernhard W., additional, Tsolaki, Magda, additional, Parnetti, Lucilla, additional, Hegerl, Ulrich, additional, Dukart, Juergen, additional, Bartolino, Alessandro, additional, Forloni, Gianluigi, additional, Richardson, Jill, additional, Frisoni, Giovanni Battista, additional, and Hensch, Tilman, additional

Published
2015
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86. Brain Arousal Regulation in Carriers of Bipolar Disorder Risk Alleles

Author

Jawinski, Philippe, primary, Sander, Christian, additional, Mauche, Nicole, additional, Spada, Janek, additional, Huang, Jue, additional, Schmidt, Anna, additional, Häntzsch, Madlen, additional, Burkhardt, Ralph, additional, Scholz, Markus, additional, Hegerl, Ulrich, additional, and Hensch, Tilman, additional

Published
2015
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87. Genetic association of objective sleep phenotypes with a functional polymorphism in the neuropeptide S receptor gene

Author

Universität Leipzig, Spada, Janek, Sander, Christian, Burkhardt, Ralph, Häntzsch, Madlen, Mergl, Roland, Scholz, Markus, Hegerl, Ulrich, Hensch, Tilman, Universität Leipzig, Spada, Janek, Sander, Christian, Burkhardt, Ralph, Häntzsch, Madlen, Mergl, Roland, Scholz, Markus, Hegerl, Ulrich, and Hensch, Tilman

Abstract

Background: The neuropeptide S receptor (NPSR1) and its ligand neuropeptide S (NPS) have received increased attention in the last few years, as both establish a previously unknown system of neuromodulation. Animal research studies have suggested that NPS may be involved in arousal/wakefulness and may also have a crucial role in sleep regulation. The single nucleotide polymorphism (SNP) rs324981 in NPSR1 has begun to shed light on a function of the NPS-system in human sleep regulation. Due to an amino acid exchange, the T-allele leads to an increased sensitivity of the NPSR1. In the only genomewide association study to date on circadian sleep parameters in humans, an association was found between rs324981 and regular bedtime. However, the sleep parameters in this study were only measured by self-rating. Therefore, our study aimed to replicate these findings using an objective measure of sleep. Methods: The study included n = 393 white subjects (62–79 years) who participated in an actigraphic assessment for determining sleep duration, rest duration, sleep onset, rest onset and sleep onset latency. Genotyping of the SNP rs324981 was performed using the TaqMan OpenArray System. Results: The genotype at rs324981 was not significantly associated with rest onset (bedtime) or sleep onset (p = .146 and p = .199, respectively). However, the SNP showed a significant effect on sleep- and rest duration (p = .007 and p = .003, respectively). Subjects that were homozygous for the minor T-allele had a significantly decreased sleep- and rest duration compared to A-allele carriers. Conclusion: The results of this study indicate that the sleep pattern in humans is influenced by the NPS-system. However, the previously reported association between bedtime and rs324981 could not be confirmed. The current finding of decreased sleep duration in T/T allele carriers is in accordance with studies in rodents reporting similar results after NPS application.:Background; Methods; Results; Conclus

Published
2014

88. Sleep disturbances and upregulation of brain arousal during daytime in depressed versus non-depressed elderly subjects.

Author

Ulke, Christine, Sander, Christian, Jawinski, Philippe, Mauche, Nicole, Huang, Jue, Spada, Janek, Wittekind, Dirk, Mergl, Roland, Luck, Tobias, Riedel-Heller, Steffi, Hensch, Tilman, and Hegerl, Ulrich

Subjects
SLEEP disorders, DEPRESSED persons, MENTAL depression risk factors, ELECTROENCEPHALOGRAPHY, DISEASES in older people, DISEASES, DISEASE risk factors
Abstract

Objectives:Although patients with depression often suffer from sleep disturbances, most of them are not sleepy. Upregulation of brain arousal has been proposed as pathophysiological mechanism explaining sleep disturbances, inner tension, autonomic hyperarousal and anhedonia in depression. The aim of the current study was to examine the association between night-time sleep disturbances and brain arousal regulation the next day in depressed versus non-depressed subjects. Methods:Twenty-eight elderly subjects (21 female; age = 70.5 ± 4.4 years) with depressive syndromes without psychotropic medication, and 28 controls (22 female; age = 70.9 ± 4.5 years), underwent a 15-min resting electroencephalogram; the Vigilance Algorithm Leipzig (VIGALL 2.1) provided an objective measure of brain arousal regulation. Sleep disturbances were assessed by a validated and self-rated sleep questionnaire. Results:In the depressive group, but not in controls, more sleep disturbances were associated with a higher brain arousal stability score (high score corresponds to upregulation) the next day (sleep onset latency:rs= 0.69,P < .0001; sleep quality:rs= −0.59,P < .001). Conclusions:The data confirm the hypothesis that in persons with depressive syndromes sleep disturbances are related to upregulation of brain arousal the next day. This finding is in line with the concept that dysregulation of brain arousal is a central pathophysiological aspect in depression. [ABSTRACT FROM AUTHOR]

Published
2017
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89. P1-216: FRONTAL CORTICAL SOURCES OF AUDITORY ODDBALL EVENT-RELATED POTENTIALS ARE RELATED TO CEREBROSPINAL FLUID β AMYLOID IN AMNESTIC MCI SUBJECTS

Author

Babiloni, Claudio, primary, Del Percio, Claudio, additional, Marzano, Nicola, additional, Noce, Giuseppe, additional, Cordone, Susanna, additional, Bagnoli, Cristina, additional, Rossini, Paolo Maria, additional, Soricelli, Andrea, additional, Nobili, Flavio, additional, Bartrés-Faz, David, additional, Blin, Oliver, additional, Payoux, Pierre, additional, Bordet, Regis, additional, Mueller, Bernhard, additional, Tsolaki, Magda, additional, Parnetti, Lucilla, additional, Hegerl, Ulrich, additional, Hensch, Tilman, additional, Dukar, Juergen, additional, Bertolino, Alessandro, additional, Forloni, Gianluigi, additional, Richardson, Jill, additional, and Frisoni, Giovanni, additional

Published
2014
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90. P1-215: CORTICAL SOURCES OF RESTING STATE EYES CLOSED EEG RHYTHMS ARE CORRELATED TO CEREBROSPINAL FLUID β AMYLOID IN AMNESTIC MCI SUBJECTS

Author

Babiloni, Claudio, primary, Del Percio, Claudio, additional, Marzano, Nicola, additional, Noce, Giuseppe, additional, Cordone, Susanna, additional, Bagnoli, Cristina, additional, Rossini, Paolo Maria, additional, Soricelli, Andrea, additional, Nobili, Flavio Mariano, additional, Bartrés-Faz, David, additional, Blin, Olivier, additional, Payoux, Pierre, additional, Bordet, Regis, additional, Mueller, Bernhard, additional, Tsolaki, Magda, additional, Parnetti, Lucilla, additional, Hegerl, Ulrich, additional, Hensch, Tilman, additional, Dukart, Juergen, additional, Bertolino, Alessandro, additional, Forloni, Gianluigi, additional, Richardson, Jill, additional, and Frisoni, Giovanni, additional

Published
2014
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91. DIFFERENTIAL EFFECTS OF APOE AND CSF AMYLOID ON MEMORY IMPAIRMENT IN INDIVIDUALS WITH AMNESTIC MCI USING THE CANTAB COGNITIVE BATTERY: RESULTS FROM THE EUROPEAN-ADNI STUDY

Author

Abbott, Rosemary A., Nathan, Pradeep J., Lim, Yen Ying, Galluzzi, Samantha, Marizzoni, Moira, Bagnoli, Cristina, Bartes-Faz, David, Bordet, Regis, Farotti, Lucia, Forlini, Gianluigi, Jovicich, Jorge, Marra, Camillo, Molinuevo, José Luis, Nobili, Flavio, Pariente, Jeremie, Parnetti, Lucilla, Payoux, Pierre, Ranjeva, Jean-Philippe, Rossini, Paolo Maria, Schonknecht, Peter, Hensch, Tilman, Soricelli, Andrea, Tsolaki, Magda, Visser, Pieter Jelle, Wiltgang, Jens, Blin, Olivier, and Frisoni, Giovanni B.

Published
2016
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92. ASSOCIATION BETWEEN EEG/ERP AND CSF MARKERS IN PRODROMAL ALZHEIMER’S DISEASE IN THE PHARMACOG PROJECT

Author

Babiloni, Claudio, Del Percio, Claudio, Marzano, Nicola, Cordone, Susanna, Noce, Giuseppe, Cavaliere, Libera, Marizzoni, Moira, Rossini, Paolo Maria, Soricelli, Andrea, Nobili, Flavio Mariano, Bartres, David, Blin, Olivier, Payoux, Pierre, Bordet, Regis, Mueller, Bernhard, Tsolaki, Magda, Parnetti, Lucilla, Hegerl, Ulrich, Hensch, Tilman, Dukart, Juergen, Forloni, Gianluigi, Richardson, Jill, and Frisoni, Giovanni B.

Published
2016
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93. BACK-TRANSLATION OF EEG/ERP MARKERS FROM AMNESTIC MCI PATIENTS TO HEALTHY YOUNG VOLUNTEERS IN THE PHARMACOG PROJECT

Author

Babiloni, Claudio, Del Percio, Claudio, Marzano, Nicola, Cordone, Susanna, Noce, Giuseppe, Marizzoni, Moira, Rossini, Paolo Maria, Soricelli, Andrea, Nobili, Flavio Mariano, Bartres, David, Blin, Olivier, Payoux, Pierre, Bordet, Regis, Mueller, Bernhard, Tsolaki, Magda, Parnetti, Lucilla, Hegerl, Ulrich, Hensch, Tilman, Dukart, Juergen, Bartolino, Alessandro, Farotti, Lucia, Salvadori, Nicola, Forloni, Gianluigi, Lanteaume, Laura, Richardson, Jill, and Frisoni, Giovanni B.

Published
2016
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94. CSF BETA-AMYLOID- AND APOE Ɛ4-RELATED DECLINE IN EPISODIC MEMORY OVER 12 MONTHS MEASURED USING THE CANTAB IN INDIVIDUALS WITH AMNESTIC MCI: RESULTS FROM THE EUROPEAN ADNI STUDY

Author

Nathan, Pradeep J., Abbott, Rosemary A., Lim, Yen Ying, Galluzzi, Samantha, Marizzoni, Moira, Bagnoli, Cristina, Babiloni, Claudio, Bartres-Faz, David, Bordet, Regis, Didic, Mira, Farotti, Lucia, Forloni, Gianluigi, Jovicich, Jorge, Marra, Camillo, Molinuevo, Jose Luis, Nobili, Flavio, Pariente, Jeremie, Parnetti, Lucilla, Payoux, Pierre, Ranjeva, Jean-Philippe, Rossini, Paolo, Schonknecht, Peter, Hensch, Tilman, Soricelli, Andrea, Tsolaki, Magda, Visser, Pieter Jelle, Wiltfang, Jens, Blin, Olivier, and Frisoni, Giovanni B.

Published
2016
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95. Electrophysiological and behavioral correlates of polymorphisms in the transcription factor AP-2beta coding gene

Author

Hensch, Tilman, Wargelius, Hanna-Linn, Herold, Ulf, Strobel, Alexander, Oreland, Lars, Brocke, Burkhard, Hensch, Tilman, Wargelius, Hanna-Linn, Herold, Ulf, Strobel, Alexander, Oreland, Lars, and Brocke, Burkhard

Abstract

Transcription factor AP-2beta may influence brain monoaminergic systems by regulating target genes. Several monoaminergic genes, including the serotonin transporter gene, have AP-2beta binding sites. Late auditory-evoked potentials (P1, N1/P2) and impulsiveness-related personality traits are correlated, and both are modulated by monoaminergic neurotransmission. The present study assesses the impact of two AP-2beta polymorphisms (VNTRs within intron 1 and 2) together with the serotonin transporter polymorphism 5-HTTLPR on late auditory-evoked potentials and personality for the first time. EEG was recorded from 91 male subjects at central electrode positions while tones of six intensity levels were presented. Additionally, subjects completed personality questionnaires. Both AP-2beta polymorphisms revealed significant main effects on P1, and haplotype analysis confirmed the contribution of both AP-2beta-polymorphisms. Additionally, AP-2beta and 5-HTTLPR showed interactions with respect to P1. 5-HTTLPR revealed a main effect on N1/P2 but not P1. Impulsiveness showed an association with intron 1 VNTR. The results are discussed with respect to differential impact of AP-2beta polymorphisms and 5-HTTLPR on the monoaminergic systems. The findings promote replication in a larger sample and suggest a potential usefulness of AP-2beta polymorphisms in explaining or predicting central nervous diseases, drug effects and side effects.

Published
2008
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96. Brain morphometry reproducibility in multi-center 3T MRI studies: A comparison of cross-sectional and longitudinal segmentations

Author

Jovicich, Jorge, primary, Marizzoni, Moira, additional, Sala-Llonch, Roser, additional, Bosch, Beatriz, additional, Bartrés-Faz, David, additional, Arnold, Jennifer, additional, Benninghoff, Jens, additional, Wiltfang, Jens, additional, Roccatagliata, Luca, additional, Nobili, Flavio, additional, Hensch, Tilman, additional, Tränkner, Anja, additional, Schönknecht, Peter, additional, Leroy, Melanie, additional, Lopes, Renaud, additional, Bordet, Régis, additional, Chanoine, Valérie, additional, Ranjeva, Jean-Philippe, additional, Didic, Mira, additional, Gros-Dagnac, Hélène, additional, Payoux, Pierre, additional, Zoccatelli, Giada, additional, Alessandrini, Franco, additional, Beltramello, Alberto, additional, Bargalló, Núria, additional, Blin, Olivier, additional, and Frisoni, Giovanni B., additional

Published
2013
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97. P3-121: Test-retest reproducibility of brain morphometry, diffusion and resting-state fMRI: A 3T consortium study

Author

Jovicich, Jorge, primary, Marizzoni, Moira, additional, Sala-Llonch, Roser, additional, Bosch, Beatriz, additional, Bartrés-Faz, David, additional, Arnold, Jennifer, additional, Benninghoff, Jens, additional, Wiltfang, Jens, additional, Roccatagliata, Luca, additional, Nobili, Flavio, additional, Hensch, Tilman, additional, Tränkner, Anja, additional, Schönknecht, Peter, additional, Leroy, Melanie, additional, Bordet, Regis, additional, Chanoine, Valérie, additional, Ranjeva, Jean-Philippe, additional, Didic, Mira, additional, Gros-Dagnac, Helene, additional, Payoux, Pierre, additional, Zoccatelli, Giada, additional, Alessandrini, Franco, additional, Beltramello, Alberto, additional, Bargallo, Nùria, additional, Blin, Oliver, additional, and Frisoni, Giovanni, additional

Published
2013
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98. IC-P-044: Test-retest reproducibility of brain morphometry, diffusion and resting-state fMRI: A 3T consortium study

Author

Jovicich, Jorge, primary, Marizzoni, Moira, additional, Sala-Llonch, Roser, additional, Bosch, Beatriz, additional, Bartrés-Faz, David, additional, Arnold, Jennifer, additional, Benninghoff, Jens, additional, Wiltfang, Jens, additional, Roccatagliata, Luca, additional, Nobili, Flavio, additional, Hensch, Tilman, additional, Tränkner, Anja, additional, Schönknecht, Peter, additional, Leroy, Melanie, additional, Bordet, Regis, additional, Chanoine, Valérie, additional, Ranjeva, Jean-Philippe, additional, Didic, Mira, additional, Gros-Dagnac, Helene, additional, Payoux, Pierre, additional, Zoccatelli, Giada, additional, Alessandrini, Franco, additional, Beltramello, Alberto, additional, Bargallò, Nùria, additional, Blin, Olivier, additional, and Frisoni, Giovanni, additional

Published
2013
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100. Assessment of Wakefulness and Brain Arousal Regulation in Psychiatric Research.

Author

Sander, Christian, Hensch, Tilman, Wittekind, Dirk Alexander, Böttger, Daniel, and Hegerl, Ulrich

Subjects
*WAKEFULNESS, *SLEEP stages, *ELECTROENCEPHALOGRAPHY, *NEUROPHARMACOLOGY, PSYCHIATRIC research
Abstract

During the last few decades, much knowledge has been gained about sleep being a heterogeneous condition with several distinct sleep stages that represent fundamentally different physiological states. The same applies for the wake state which also comprises distinct global functional states (called vigilance stages). However, various terms and concepts have been introduced describing different aspects of wakefulness, and accordingly several methods of assessment exist, e.g. sleep laboratory assessments (Multiple Sleep Latency Test, Maintenance of Wakefulness Test), questionnaires (Epworth Sleepiness Scale, Karolinska Sleepiness Scale), behavioural tasks (Psychomotor Vigilance Test) or electroencephalography (EEG)-based assessments (Alpha Attenuation Test, Karolinska Drowsiness Test). Furthermore, several theoretical concepts about the regulation of sleep and wakefulness have been put forward, and physiological correlates have been identified. Most relevant for healthy functioning is the regulation of brain arousal and the adaption of wakefulness to the environmental and situational needs so that the optimal balance between energy conservation and responsiveness can be obtained. Since one approach to the assessment of brain arousal regulation is the classification of EEG vigilance stages, a computer-based algorithm (Vigilance Algorithm Leipzig) has been introduced, allowing classification of EEG vigilance stages in EEG recordings under resting conditions. The time course of EEG vigilance stages in EEGs of 15-20 min duration allows estimation of the individual arousal regulation (hyperstable, adaptive, or unstable vigilance pattern). The vigilance model of affective disorders and attention-deficit/hyperactivity disorder links a disturbed arousal regulation to the pathogenesis of psychiatric disorders and accordingly helps to explain and possibly also predict treatment effects of pharmacological and non-pharmacological interventions for these conditions. © 2016 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2016
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