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51. Prediction of risk for bleeding, myocardial infarction and mortality after percutaneous coronary intervention in patients with acute coronary syndromes

Author

Ndrepepa, Gjin, Neumann, Franz-Josef, Menichelli, Maurizio, Richardt, Gert, Cassese, Salvatore, Xhepa, Erion, Kufner, Sebastian, Lahu, Shqipdona, Aytekin, Alp, Sager, Hendrik B., Joner, Michael, Ibrahim, Tareq, Müller, Arne, Fusaro, Massimiliano, Hapfelmeier, Alexander, Laugwitz, Karl-Ludwig, Schunkert, Heribert, Kastrati, Adnan, and Kasel, Markus

Published
2022
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52. Protocol for a randomized, placebo-controlled, double-blind phase IIa study of the safety, tolerability, and symptomatic efficacy of the ROCK-inhibitor Fasudil in patients with Parkinson’s disease (ROCK-PD)

Author

Wolff, Andreas W., primary, Bidner, Helen, additional, Remane, Yvonne, additional, Zimmer, Janine, additional, Aarsland, Dag, additional, Rascol, Olivier, additional, Wyse, Richard K., additional, Hapfelmeier, Alexander, additional, and Lingor, Paul, additional

Published
2024
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55. Frequency, persistence and relation of disease symptoms, psychosomatic comorbidity and daily life impairment after COVID-19: a cohort study in general practice.

Author

Hapfelmeier, Alexander, Donhauser, Jan, Teusen, Clara, Eck, Stefanie, and Schneider, Antonius

Subjects
*SOMATOFORM disorders, *RISK assessment, *FAMILY medicine, *T-test (Statistics), *STATISTICAL significance, *MULTIPLE regression analysis, *PRIMARY health care, *MEDICALLY unexplained symptoms, *MULTIVARIATE analysis, *CHI-squared test, *DESCRIPTIVE statistics, *LONGITUDINAL method, *ODDS ratio, *PSYCHOSOMATIC disorders, *QUALITY of life, *STATISTICS, *ANALYSIS of variance, *COMPARATIVE studies, *SOCIODEMOGRAPHIC factors, *DATA analysis software, *COVID-19, *COMORBIDITY, *ACTIVITIES of daily living, *DISEASE risk factors
Abstract

Background: Long-lasting symptoms with a possible relation to psychosomatic comorbidity have been described following COVID-19. However, data is sparse in general practice. The trial's objective was to investigate the time-dependent frequency of disease symptoms and relation to psychosomatic comorbidity and daily life impairment (DLI). Methods: Comparative cohort study of patients reporting a previous SARS-CoV-2 infection and uninfected controls in general practice. Participants were recruited in 14 general practices in the greater Munich area. Data collection was questionnaire based with a 12 months follow-up. Descriptive statistics, multivariable regression and bivariate correlations were used for analysis. Results: A total of n = 204 cases infected up to 42 months ago (n = 141 Omicron, n = 63 earlier variants), and n = 119 controls were included. Disease symptoms were substantially more prevalent in cases (55–79% vs. 43% within one year of infection). This difference also appeared in the multivariable analysis adjusting for socio-demographics and psychosomatic comorbidity with odds ratios (OR) of 4.15 (p < 0.001) and 3.51 (p = 0.054) for the cohorts with Omicron or earlier variants infection (vs. controls), respectively. It was persistent with earlier variants (OR 1.00 per month, p = 0.903), while a decreasing trend was observed for Omicron (OR 0.89 per month, p < 0.001). DLI was especially correlated with fatigue (r = 0.628). Conclusion: DLI, psychosomatic comorbidity and independently increased disease symptoms require holistic treatment of the patient in general practice according to the bio-psycho-social model. A key role in restoring the daily life capability may be attributed to the symptom fatigue. [ABSTRACT FROM AUTHOR]

Published
2024
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56. Structure and quality of bedside teaching: A videographic analysis.

Author

Blaschke, Anna-Lena, Hapfelmeier, Alexander, Rubisch, Hannah P. K., Berberat, Pascal O., and Gartmeier, Martin

Subjects
*STATISTICAL correlation, *PEARSON correlation (Statistics), *MEDICAL education, *RESEARCH funding, *CRONBACH'S alpha, *EDUCATIONAL outcomes, *QUESTIONNAIRES, *UNDERGRADUATES, *TEACHING methods, *HOSPITAL patients, *DESCRIPTIVE statistics, *TEACHERS, *MOTIVATION (Psychology), *ROOMS, *CLINICAL competence, *CLINICAL education, *QUALITY assurance, *LEARNING strategies, *DATA analysis software, *TIME, *VIDEO recording
Abstract

Bedside teaching (BST) is a core element of medical education. In light of a reported decrease in BST, evidence on how to use BST time most efficiently should be developed. Given that little research into the tangible quality characteristics of good BST has been reported, we investigated the influence of various teacher and structural characteristics on the perceived quality of BST. We filmed and coded 36 BSTs involving 24 lecturers and 259 students. Structural characteristics of interest were: number of students and patients, overall duration, and the proportion of clinical examination. Lecturer questionnaires provided insight into teaching experience and intrinsic motivation, and student evaluations assessed the quality of BSTs in three dimensions. Correlations are reported using the Pearson r and a linear mixed model (LMM). The intrinsic motivation of lecturers was significantly positively correlated with perceived quality, but their experience was only weakly so correlated. In the LMM, a significant association was observed for the quality dimension of clinical teaching with the number of patients and the proportion of time spent on clinical examination. Based on our findings, we recommend including multiple patients in BSTs, and providing substantial opportunities for clinical examination. Regarding lecturers, motivation matters more than experience. [ABSTRACT FROM AUTHOR]

Published
2024
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67. 1032. Are enterococcal blood stream infections an independent risk factor for a poorer 5-year survival or just a marker for severity of illness? - The Munich Multi-Centric Enterococci cohort

Author

Bachfischer, Tobias, primary, Wurst, Milena, additional, Karapetyan, Siranush, additional, Hapfelmeier, Alexander, additional, Schneider, Jochen, additional, Gleich, Sabine, additional, Dichtl, Karl, additional, Schmid, Roland, additional, Wagner, Laura, additional, Triebelhorn, Julian, additional, Erber, Johanna, additional, Seybold, Ulrich, additional, burgkart, rainer, additional, obermeier, Andreas, additional, Voit, Floran, additional, Busch, Dirk, additional, Rämer, patrick, additional, Spinner, Christoph, additional, and Rothe, kathrin, additional

Published
2023
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71. Are enterococcal bloodstream infections an independent risk factor for a poorer 5-year survival or just a marker for severity of illness?—The Munich multicentric enterococci cohort

Author

Rothe, Kathrin, primary, Bachfischer, Tobias, additional, Karapetyan, Siranush, additional, Hapfelmeier, Alexander, additional, Wurst, Milena, additional, Gleich, Sabine, additional, Dichtl, Karl, additional, Schmid, Roland M., additional, Triebelhorn, Julian, additional, Wagner, Laura, additional, Erber, Johanna, additional, Voit, Florian, additional, Burgkart, Rainer, additional, Obermeier, Andreas, additional, Seibold, Ulrich, additional, Busch, Dirk H., additional, Rämer, Patrick C., additional, Spinner, Christoph D., additional, and Schneider, Jochen, additional

Published
2023
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74. Ticagrelor or Prasugrel in Patients With ST-Segment–Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Author

Aytekin, Alp, Ndrepepa, Gjin, Neumann, Franz-Josef, Menichelli, Maurizio, Mayer, Katharina, Wöhrle, Jochen, Bernlochner, Isabell, Lahu, Shqipdona, Richardt, Gert, Witzenbichler, Bernhard, Sibbing, Dirk, Cassese, Salvatore, Angiolillo, Dominick J., Valina, Christian, Kufner, Sebastian, Liebetrau, Christoph, Hamm, Christian W., Xhepa, Erion, Hapfelmeier, Alexander, Sager, Hendrik B., Wustrow, Isabel, Joner, Michael, Trenk, Dietmar, Fusaro, Massimiliano, Laugwitz, Karl-Ludwig, Schunkert, Heribert, Schüpke, Stefanie, and Kastrati, Adnan

Published
2020
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80. Effects of Early Clozapine Treatment on Remission Rates in Acute Schizophrenia (The EARLY Trial): Protocol of a Randomized-Controlled Multicentric Trial

Author

Wagner, Elias, additional, Strube, Wolfgang, additional, Görlitz, Thomas, additional, Aksar, Aslihan, additional, Bauer, Ingrid, additional, Campana, Mattia, additional, Moussiopoulou, Joanna, additional, Hapfelmeier, Alexander, additional, Wagner, Petra, additional, Egert-Schwender, Silvia, additional, Bittner, Robert, additional, Eckstein, Kathrin, additional, Nenadić, Igor, additional, Kircher, Tilo, additional, Langguth, Berthold, additional, Meisenzahl, Eva, additional, Lambert, Martin, additional, Neff, Sigrid, additional, Malchow, Berend, additional, Falkai, Peter, additional, Hirjak, Dusan, additional, Böttcher, Kent-Tjorben, additional, Meyer-Lindenberg, Andreas, additional, Blankenstein, Christiane, additional, Leucht, Stefan, additional, and Hasan, Alkomiet, additional

Published
2023
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88. Greedy knot selection algorithm for restricted cubic spline regression.

Author

Arnes, Jo Inge, Hapfelmeier, Alexander, Horsch, Alexander, and Braaten, Tonje

Subjects
*GREEDY algorithms, *REGRESSION analysis, *PROPORTIONAL hazards models, *NONLINEAR analysis, *POLYNOMIALS
Abstract

Non-linear regression modeling is common in epidemiology for prediction purposes or estimating relationships between predictor and response variables. Restricted cubic spline (RCS) regression is one such method, for example, highly relevant to Cox proportional hazard regression model analysis. RCS regression uses third-order polynomials joined at knot points to model non-linear relationships. The standard approach is to place knots by a regular sequence of quantiles between the outer boundaries. A regression curve can easily be fitted to the sample using a relatively high number of knots. The problem is then overfitting, where a regression model has a good fit to the given sample but does not generalize well to other samples. A low knot count is thus preferred. However, the standard knot selection process can lead to underperformance in the sparser regions of the predictor variable, especially when using a low number of knots. It can also lead to overfitting in the denser regions. We present a simple greedy search algorithm using a backward method for knot selection that shows reduced prediction error and Bayesian information criterion scores compared to the standard knot selection process in simulation experiments. We have implemented the algorithm as part of an open-source R-package, knutar. [ABSTRACT FROM AUTHOR]

Published
2024
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91. Figure S5 from The Chemokine CX3CL1 Improves Trastuzumab Efficacy in HER2 Low–Expressing Cancer In Vitro and In Vivo

Author

Dreyer, Tobias F., primary, Kuhn, Sabine, primary, Stange, Christoph, primary, Heithorst, Nadine, primary, Schilling, Daniela, primary, Jelsma, Jil, primary, Sievert, Wolfgang, primary, Seitz, Stefanie, primary, Stangl, Stefan, primary, Hapfelmeier, Alexander, primary, Noske, Aurelia, primary, Wege, Anja K., primary, Weichert, Wilko, primary, Ruland, Jürgen, primary, Schmitt, Manfred, primary, Dorn, Julia, primary, Kiechle, Marion, primary, Reuning, Ute, primary, Magdolen, Viktor, primary, Multhoff, Gabriele, primary, and Bronger, Holger, primary

Published
2023
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92. Data from The Chemokine CX3CL1 Improves Trastuzumab Efficacy in HER2 Low–Expressing Cancer In Vitro and In Vivo

Author

Dreyer, Tobias F., primary, Kuhn, Sabine, primary, Stange, Christoph, primary, Heithorst, Nadine, primary, Schilling, Daniela, primary, Jelsma, Jil, primary, Sievert, Wolfgang, primary, Seitz, Stefanie, primary, Stangl, Stefan, primary, Hapfelmeier, Alexander, primary, Noske, Aurelia, primary, Wege, Anja K., primary, Weichert, Wilko, primary, Ruland, Jürgen, primary, Schmitt, Manfred, primary, Dorn, Julia, primary, Kiechle, Marion, primary, Reuning, Ute, primary, Magdolen, Viktor, primary, Multhoff, Gabriele, primary, and Bronger, Holger, primary

Published
2023
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93. Table S1 from The Chemokine CX3CL1 Improves Trastuzumab Efficacy in HER2 Low–Expressing Cancer In Vitro and In Vivo

Author

Dreyer, Tobias F., primary, Kuhn, Sabine, primary, Stange, Christoph, primary, Heithorst, Nadine, primary, Schilling, Daniela, primary, Jelsma, Jil, primary, Sievert, Wolfgang, primary, Seitz, Stefanie, primary, Stangl, Stefan, primary, Hapfelmeier, Alexander, primary, Noske, Aurelia, primary, Wege, Anja K., primary, Weichert, Wilko, primary, Ruland, Jürgen, primary, Schmitt, Manfred, primary, Dorn, Julia, primary, Kiechle, Marion, primary, Reuning, Ute, primary, Magdolen, Viktor, primary, Multhoff, Gabriele, primary, and Bronger, Holger, primary

Published
2023
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94. Differentiation of Spontaneous Bacterial Peritonitis from Secondary Peritonitis in Patients with Liver Cirrhosis: Retrospective Multicentre Study

Author

Würstle, Silvia, primary, Hapfelmeier, Alexander, additional, Karapetyan, Siranush, additional, Studen, Fabian, additional, Isaakidou, Andriana, additional, Schneider, Tillman, additional, Schmid, Roland M., additional, von Delius, Stefan, additional, Gundling, Felix, additional, Burgkart, Rainer, additional, Obermeier, Andreas, additional, Mayr, Ulrich, additional, Ringelhan, Marc, additional, Rasch, Sebastian, additional, Lahmer, Tobias, additional, Geisler, Fabian, additional, Turner, Paul E., additional, Chan, Benjamin K., additional, Spinner, Christoph D., additional, and Schneider, Jochen, additional

Published
2023
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95. Abstract P6-01-24: Long-term outcome data using Endopredict® as risk stratification and chemotherapy decision biomarker in hormone receptor positive, HER2-negative early breast cancer

Author

Klein, Evelyn, primary, Josipovic, Adriana, additional, Noske, Aurelia, additional, Anders, Sophie, additional, Mogler, Carolin, additional, Weichert, Wilko, additional, Hapfelmeier, Alexander, additional, Kiechle, Marion, additional, and Ettl, Johannes, additional

Published
2023
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96. HelicoPTER – lokale Prävalenz, Therapieerfolg und Antibiotikaresistenz der Helicobacter pylori-Infektion in Deutschland

Author

Schulz, Christian, additional, Macke, Lukas, additional, Vasapolli, Riccardo, additional, Bronny, KathrinMaria, additional, Hysenaj, Olsi, additional, Dichtl, Karl, additional, Crowell, Claudia, additional, Lang, Ulrich, additional, Spießberger, Beate, additional, Burrell, Teresa, additional, Conzelmann, Nadine, additional, Werner, Christoph, additional, Heidrich, Benjamin, additional, Kirschner, Janina, additional, Ulm, Kurt, additional, Hapfelmeier, Alexander, additional, Vieth, Michael, additional, Suerbaum, Sebastian, additional, and Gerhard, Markus, additional

Published
2023
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98. Significant Tumor Regression after Neoadjuvant Chemotherapy in Gastric Cancer, but Poor Survival of the Patient? Role of MHC Class I Alterations

Author

Hiltner, Theresa, primary, Szörenyi, Noémi, additional, Kohlruss, Meike, additional, Hapfelmeier, Alexander, additional, Herz, Anna-Lina, additional, Slotta-Huspenina, Julia, additional, Jesinghaus, Moritz, additional, Novotny, Alexander, additional, Lange, Sebastian, additional, Ott, Katja, additional, Weichert, Wilko, additional, and Keller, Gisela, additional

Published
2023
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99. Retrospective cohort study to devise a treatment decision score predicting adverse 24-month radiological activity in early multiple sclerosis

Author

Hapfelmeier, Alexander, primary, On, Begum Irmak, additional, Mühlau, Mark, additional, Kirschke, Jan S., additional, Berthele, Achim, additional, Gasperi, Christiane, additional, Mansmann, Ulrich, additional, Wuschek, Alexander, additional, Bussas, Matthias, additional, Boeker, Martin, additional, Bayas, Antonios, additional, Senel, Makbule, additional, Havla, Joachim, additional, Kowarik, Markus C., additional, Kuhn, Klaus, additional, Gatz, Ingrid, additional, Spengler, Helmut, additional, Wiestler, Benedikt, additional, Grundl, Lioba, additional, Sepp, Dominik, additional, and Hemmer, Bernhard, additional

Published
2023
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100. Prior Myocardial Infarction and Treatment Effect of Ticagrelor Versus Prasugrel in Patients With Acute Coronary Syndromes ‐ A Post‐hoc Analysis of the ISAR‐REACT 5 Trial

Author

Lahu, Shqipdona, primary, Scalamogna, Maria, additional, Ndrepepa, Gjin, additional, Menichelli, Maurizio, additional, Valina, Christian, additional, Hemetsberger, Rayyan, additional, Witzenbichler, Bernhard, additional, Bernlochner, Isabell, additional, Joner, Michael, additional, Xhepa, Erion, additional, Hapfelmeier, Alexander, additional, Kufner, Sebastian, additional, Sager, Hendrik B., additional, Mayer, Katharina, additional, Kessler, Thorsten, additional, Laugwitz, Karl‐Ludwig, additional, Richardt, Gert, additional, Schunkert, Heribert, additional, Neumann, Franz‐Josef, additional, Kastrati, Adnan, additional, and Cassese, Salvatore, additional

Published
2022
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