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Frequency, persistence and relation of disease symptoms, psychosomatic comorbidity and daily life impairment after COVID-19: a cohort study in general practice.
- Source :
-
BMC Primary Care . 8/10/2024, Vol. 25 Issue 1, p1-9. 9p. - Publication Year :
- 2024
-
Abstract
- Background: Long-lasting symptoms with a possible relation to psychosomatic comorbidity have been described following COVID-19. However, data is sparse in general practice. The trial's objective was to investigate the time-dependent frequency of disease symptoms and relation to psychosomatic comorbidity and daily life impairment (DLI). Methods: Comparative cohort study of patients reporting a previous SARS-CoV-2 infection and uninfected controls in general practice. Participants were recruited in 14 general practices in the greater Munich area. Data collection was questionnaire based with a 12 months follow-up. Descriptive statistics, multivariable regression and bivariate correlations were used for analysis. Results: A total of n = 204 cases infected up to 42 months ago (n = 141 Omicron, n = 63 earlier variants), and n = 119 controls were included. Disease symptoms were substantially more prevalent in cases (55–79% vs. 43% within one year of infection). This difference also appeared in the multivariable analysis adjusting for socio-demographics and psychosomatic comorbidity with odds ratios (OR) of 4.15 (p < 0.001) and 3.51 (p = 0.054) for the cohorts with Omicron or earlier variants infection (vs. controls), respectively. It was persistent with earlier variants (OR 1.00 per month, p = 0.903), while a decreasing trend was observed for Omicron (OR 0.89 per month, p < 0.001). DLI was especially correlated with fatigue (r = 0.628). Conclusion: DLI, psychosomatic comorbidity and independently increased disease symptoms require holistic treatment of the patient in general practice according to the bio-psycho-social model. A key role in restoring the daily life capability may be attributed to the symptom fatigue. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SOMATOFORM disorders
*RISK assessment
*FAMILY medicine
*T-test (Statistics)
*STATISTICAL significance
*MULTIPLE regression analysis
*PRIMARY health care
*MEDICALLY unexplained symptoms
*MULTIVARIATE analysis
*CHI-squared test
*DESCRIPTIVE statistics
*LONGITUDINAL method
*ODDS ratio
*PSYCHOSOMATIC disorders
*QUALITY of life
*STATISTICS
*ANALYSIS of variance
*COMPARATIVE studies
*SOCIODEMOGRAPHIC factors
*DATA analysis software
*COVID-19
*COMORBIDITY
*ACTIVITIES of daily living
*DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 27314553
- Volume :
- 25
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- BMC Primary Care
- Publication Type :
- Academic Journal
- Accession number :
- 178969848
- Full Text :
- https://doi.org/10.1186/s12875-024-02551-w