51. Comprehensive analysis of 19 cannabinoids in commercial CBD oils: concentrations, profiles, and safety implications.
- Author
-
Lindekamp, Niklas, Weigel, Stefan, Sachse, Benjamin, Schäfer, Bernd, Rohn, Sascha, and Triesch, Nadja
- Subjects
LIQUID chromatography-mass spectrometry ,HIGH performance liquid chromatography ,DIETARY supplements ,CANNABINOIDS ,CANNABIDIOL - Abstract
Nineteen cannabinoids, including Δ
9 -THC (tetrahydrocannabinol) and CBD (cannabidiol), were quantified in 22 CBD oils, 2 CBG (cannabigerol) oils, and 2 CBN (cannabinol) oils, marketed as food supplements, aroma oils, or cosmetic preparations. Analyses were conducted using high-performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS). The declared concentrations of CBD (or CBG, CBN) in the oils ranged from 2.5 to 20%. Actual concentrations compared to declared concentrations ranged from 81 to 226%. CBD concentrations of up to 9 mg per drop were found. Δ9 -THC was detected in 20 of 26 samples, with concentrations ranging from 5 to 1576 mg/kg (mean = 536 mg/kg). Considering the highest daily intake suggested by one manufacturer (20 drops) and a body weight of 70 kg, the measured Δ9 -THC concentration in 50% (n = 13) of the products would exceed the acute reference dose (ARfD) of 1 µg/kg body weight (bw) derived for Δ9 -THC by the European Food Safety Authority (EFSA). For 7 samples, only 2 drops of oil would be sufficient to exceed the ARfD of Δ9 -THC. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF