RETRACTED: L-Arginine Uptake by Cationic Amino Acid Transporter Promotes Intra-Macrophage Survival of Leishmania donovani by Enhancing Arginase-Mediated Polyamine Synthesis.

This article explores the role of l-arginine transport in the survival of Leishmania donovani, a parasite that causes Indian visceral leishmaniasis (VL), within macrophages. The study found that the availability of extracellular l-arginine is crucial for the survival of the parasite inside macrophages. The researchers also discovered that the CAT-2 isoform of the cationic amino acid transporter is associated with l-arginine transport in infected macrophages. The study suggests that targeting l-arginine metabolism and l-arginine-metabolizing enzymes could be a potential therapeutic strategy for treating VL. [Extracted from the article]