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52. Interstitial Lung Abnormalities Detected by CT in Asbestos-Exposed Subjects Are More Likely Associated to Age

Author

Laurent, François, primary, Benlala, Ilyes, additional, Dournes, Gael, additional, Gramond, Celine, additional, Thaon, Isabelle, additional, Clin, Bénédicte, additional, Brochard, Patrick, additional, Gislard, Antoine, additional, Andujar, Pascal, additional, Chammings, Soizick, additional, Gallet, Justine, additional, Lacourt, Aude, additional, Delva, Fleur, additional, Paris, Christophe, additional, Ferretti, Gilbert, additional, and Pairon, Jean-Claude, additional more...

Published
2021
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53. Orientación para la selección de compras de innovación

Author

Madramany-Sanchis P, Badia JD, Serrano-Cantó I, Ribes-Greus A, Bougrain F, Gislard AC, Balasko M, Flori P, Horvatic I, Kuharic B, Maio B, Martins S, Navarro-Jover JM, Nunes E, Pacheco P, Premec D, Simic I, Teruel-Juanes, R, and Mattioli D more...

Subjects
Eficiencia energética, Crecimiento verde, Compra pública de innovación
Abstract

El objetivo de estas directrices es disminuir estas barreras tradicionales a las que se enfrentan las autoridades locales y ayudarles a adoptar prácticas de compra inovadora. Se indicarán los pasos clave para diseñar e implementar un proceso de compra innovadora. Cuatro municipios involucrados en PROMINENT-MED lanzaron PPI para la renovación de un edificio público: • El municipio de Alzira en España: el proyecto piloto se centra en la remodelación de un viejo (1891) edificio de almacenamiento de naranjas ("Magatzem de Cucó"). • El municipio de Koprivnica en Croacia: el proyecto piloto implica la renovación eficiente de la energía de un jardín de infancia prefabricado. • El municipio de Mértola: el proyecto piloto se refiere a la renovación del Ayuntamiento que también alberga la parte romana del museo de Mértola. • El municipio de Narni en Italia: el caso piloto se aplica para la remodelación de un jardín de infancia que acoge a niños de 6 a 36 meses. Los objetivos de esta guía, que se dirige a las autoridades públicas y los pequeños municipios, es proporcionar una visión general completa de los pasos clave a seguir para implementar un proceso de compra de innovación. Las directrices no solo serán un enfoque paso a paso para la compra de innovación, sino que también establecerán las especificidades de las pequeñas autoridades públicas y las peculiaridades de los proyectos de renovación., Madramany-Sanchis P.,Badia JD.,Serrano-Cantó I., Ribes-Greus A., Bougrain F., Gislard AC., Balaško Kiš M., Flori P., Horvatic I., Kuharic B., Maio B., Martins S., Navarro-Jover J.M., Nunes E., Pacheco P., Premec D., Šimić I., Teruel-Juanes R., and D. Mattioli, 2018, Orientación para la selección de compras de innovación, Prominent MED project (Public Procurement of Innovation Boosting Green Growth in the MED area, 1MED15-1.1-M12-070) Interreg Mediterranean, Proyecto cofinanciado por los Fondos de Desarrollo Regional Europeo. DOI: 10.5281/zenodo.4250819 more...

Published
2020
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54. Recycled products are not always skin-friendly: Occupational dermatitis due to recycled plastic

Author

N. Lesueur, Florence Tetart, J.F. Gehanno, O. Bauvin, Pascal Joly, A. Kuntz, J. Bouteiller, and A. Gislard

Subjects
Occupational Dermatitis, Waste management, business.industry, Dermatology, Recycled products, medicine.disease, Dermatitis, Occupational, Dermatitis, Allergic Contact, Medicine, Dermatitis, Irritant, Humans, Recycling, business, Contact dermatitis, Plastics, Skin
Published
2020

56. Occupational asthma and occupational rhinitis: the united airways disease model revisited

Author

Ameille, Jacques, Hamelin, Karine, Andujar, Pascal, Bensefa-Colas, Lynda, Bonneterre, Vincent, Dupas, Dominique, Garnier, Robert, Loddé, Brice Alain, Rinaldo, Mickael, Descatha, Alexis, Lasfargues, Gérard, Pairon, Jean-Claude, Doutrellot-Philippon, C, Thaon, I, Brochard, P, Verdun-Esquer, C, Dewitte, JD, Lodde, B, Letourneux, M, Clin, B, Marquignon, MF, Chamoux, A, Gabrillargues, D, Pairon, JC, Andujar, P, Ameille, J, Descatha, A, de Gaudemaris, R, Bonneterre, V, Gislard, A, Lepage, N, Nisse, C, Bergeret, A, Normand, JC, Le Hucher-Michel, MP, Roulet, A, Paris, C, Penven, E, Dupas, D, Choudat, D, Bensefa-Colas, L, Garnier, R, Villa, A, Ben-Brik, E, Berson, C, Deschamps, F, Lesage, FX, Gehanno, JF, Fontana, L, Orset, C, Cantineau, A, Kleinogel, S, Soulat, JM, and Hérin, F more...

Published
2013
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58. Pleural Plaques and the Risk of Pleural Mesothelioma

Author

Pairon, Jean-Claude, Laurent, François, Rinaldo, Mickaël, Clin, Bénédicte, Andujar, Pascal, Ameille, Jacques, Brochard, Patrick, Chammings, Soizick, Ferretti, Gilbert, Galateau-Sallé, Françoise, Gislard, Antoine, Letourneux, Marc, Luc, Amandine, Schorlé, Evelyne, and Paris, Christophe more...

Published
2013
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59. Brain virtual histology with X-ray phase-contrast tomography Part II: 3D morphologies of amyloid-β plaques in Alzheimer’s disease models

Author

Chourrout, Matthieu, primary, Roux, Margaux, additional, Boisvert, Carlie, additional, Gislard, Coralie, additional, Legland, David, additional, Arganda-Carreras, Ignacio, additional, Olivier, Cécile, additional, Peyrin, Françoise, additional, Boutin, Hervé, additional, Rama, Nicolas, additional, Baron, Thierry, additional, Meyronet, David, additional, Brun, Emmanuel, additional, Rositi, Hugo, additional, Wiart, Marlène, additional, and Chauveau, Fabien, additional more...

Published
2021
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61. Évaluation médico-économique d’un programme de dépistage des cancers broncho-pulmonaires chez des sujets exposés à l’amiante

Author

Gendarme, S., primary, Pairon, J.C., additional, Goussault, H., additional, Andujar, P., additional, Chamming's, S., additional, Gramond, C., additional, Laurent, F., additional, Brochard, P., additional, Clin, B., additional, Gislard, A., additional, Lacourt, A., additional, Paris, C., additional, and Chouaid, C., additional more...

Published
2021
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65. Prevalence of occupational exposure to asbestos and crystalline silica according to phenotypes of lung cancer from the CaProMat study: A case-only study

Author

Isabelle Stücker, Jack Siemiatycki, Christophe Paris, Pascale Salameh, Jean Claude Pairon, Fleur Delva, Antoine Gislard, Vincent Bonneterre, Bénédicte Clin, Mohamad El Zoghbi, Patrick Brochard, Aude Lacourt, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Lebanese University [Beirut] (LU), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Interactions Gènes-Risques environnementaux et Effets sur la Santé (INGRES), Université de Lorraine (UL), Centre de consultations de pathologies professionnelles [CHRU Nancy] (CCPP), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), CHI Créteil, Service de santé au travail et pathologie professionnelle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Aliments Bioprocédés Toxicologie Environnements (ABTE), Université de Caen Normandie (UNICAEN), Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM), Environnement et Prédiction de la Santé des Populations (TIMC-IMAG-EPSP), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Centre Hospitalier Universitaire [Grenoble] (CHU), Cancers et Populations : Facteurs de Risque, Depistage, Pratiques Diagnostiques et Therapeutiques, Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM) more...

Subjects
Male, Pathology, medicine.medical_specialty, Lung Neoplasms, Histological types, [SDV]Life Sciences [q-bio], Age at diagnosis, medicine.disease_cause, Asbestos, 03 medical and health sciences, 0302 clinical medicine, Occupational Exposure, Prevalence, medicine, Humans, Lung cancer, Histological type, business.industry, Smoking, Significant difference, Quebec, Public Health, Environmental and Occupational Health, Middle Aged, respiratory system, Silicon Dioxide, medicine.disease, 030210 environmental & occupational health, Crystalline silica, 3. Good health, Occupational Diseases, Phenotype, [SDV.TOX]Life Sciences [q-bio]/Toxicology, 030220 oncology & carcinogenesis, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, sense organs, Occupational exposure, business
Abstract

International audience; BackgroundThe objective of the study was to compare the prevalence of occupational exposure to asbestos and crystalline silica according to histological types of lung cancer and age at diagnosis.MethodsCaProMat study is a pooled case‐only study conducted between 1996 and 2011. The current study consisted of 6521 lung cancer cases. Occupational exposure to asbestos and crystalline silica was assessed by two Job‐Exposure Matrices. A weighted prevalence of exposure was derived and compared according to histological types and age at diagnosis.ResultsThere was no difference of weighted prevalence of exposure to asbestos and crystalline silica according to histological types of lung cancer. There was a statistically significant difference of weighted prevalence of exposure to asbestos and crystalline silica according to age at diagnosis.ConclusionsDue to the limited clinical importance of the difference, neither the histological type, nor the age at diagnosis can be used as an indicator for the occupational exposure to asbestos or crystalline silica. more...

Published
2017
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68. Occupational asbestos exposure and incidence of colon and rectal cancers in French men: the asbestos-related diseases cohort (ARDCo-Nut)

Author

Paris, Christophe, Thaon, Isabelle, Herin, Fabrice, Clin, Benedicte, Lacourt, Aude, Luc, Amandine, Coureau, Gaelle, Brochard, Patrick, Chammings, Soizick, Gislard, Antoine, Galan, Pilar, Hercberg, Serge, Wild, Pascal, Pairon, Jean-Claude, and Andujar, Pascal more...

Subjects
Analysis, Risk factors, Health aspects, Colon cancer -- Risk factors -- Analysis, Occupational exposure -- Analysis, Asbestos -- Analysis -- Health aspects
Abstract

Introduction Asbestos exposure is associated with several malignancies including lung cancer, mesothelioma, and more recently, ovarian and laryngeal cancers (IARC 2012). However, the role of asbestos in the pathogenesis of [...], BACKGROUND: The relationships between asbestos exposure and colorectal cancer remain controversial. OBJECTIVES: We examined the association between asbestos exposure and colorectal cancer incidence. METHODS: Volunteer retired workers previously exposed to asbestos were invited to participate in the French ARDCo screening program between 2003 and 2005. Additional data on risk factors for colorectal cancer were collected from the ARDCo-Nut subsample of 3,769 participants in 2011. Cases of colon and rectal cancer were ascertained each year through 2014 based on eligibility for free medical care following a cancer diagnosis. Survival regression based on the Cox model was used to estimate the relative risk of colon and rectal cancer separately, in relation to the time since first exposure (TSFE) and cumulative exposure index (CEI) to asbestos, and with adjustment for smoking in the overall cohort and for smoking, and certain risk factors for these cancers in the ARDCo-Nut subsample. RESULTS: Mean follow-up was 10.2 years among 14,515 men, including 181 colon cancer and 62 rectal cancer cases (41 and 17, respectively, in the ARDCo-Nut subsample). In the overall cohort, after adjusting for smoking, colon cancer was significantly associated with cumulative exposure (HR = 1.14; 95% CI: 1.04, 1.26 for a 1-unit increase in In-CEI) and [greater than or equal to] 20-40 years since first exposure (HR = 4.67; 95% CI: 1.92, 11.46 vs. 0-20 years TSFE), and inversely associated with 60 years TSFE (HR = 0.26; 95% CI: 0.10, 0.70). Although rectal cancer was also associated with TSFE 20-40 years (HR = 4.57; 95% CI: 1.14, 18.27), it was not associated with ln-CEI, but these findings must be interpreted cautiously due to the small number of cases. CONCLUSIONS: Our findings provide support for an association between occupational exposure to asbestos and colon cancer incidence in men. http://dx.doi.org/10.1289/EHP153 more...

Published
2017
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69. Long-term exposure to near-future ocean acidification does not affect the expression of neurogenesis- and synaptic transmission-related genes in the olfactory bulb of European sea bass (Dicentrarchus labrax)

Author

José-Luis Zambonino-Infante, Arianna Servili, David Mazurais, Sebastien Gislard, Nicolas Le Bayon, Lauriane Madec, Laboratoire des Sciences de l'Environnement Marin (LEMAR) (LEMAR), Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Brest (UBO)-Institut Universitaire Européen de la Mer (IUEM), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut Français de Recherche pour l'Exploitation de la Mer - Brest (IFREMER Centre de Bretagne), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), ANR-10-LABX-0019,LabexMER,LabexMER Marine Excellence Research: a changing ocean(2010), and Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS) more...

Subjects
030110 physiology, 0106 biological sciences, 0301 basic medicine, Olfactory system, Olfactory bulbs, Fish Proteins, ability, Physiology, Neurogenesis, Oceans and Seas, Sensory system, Olfaction, system, 010603 evolutionary biology, 01 natural sciences, Biochemistry, Synaptic Transmission, fish behavior, 03 medical and health sciences, Endocrinology, Neuroplasticity, Animals, Homeostasis, Seawater, 14. Life underwater, neurotransmission, Sea bass, Ecology, Evolution, Behavior and Systematics, biology, ACL, Ocean acidification, gaba(a), Long-term exposure, Carbon Dioxide, Hydrogen-Ion Concentration, biology.organism_classification, Olfactory Bulb, Olfactory bulb, Cell biology, co2, Animal Science and Zoology, Dicentrarchus, Bass, Gene expression, [SDE.BE]Environmental Sciences/Biodiversity and Ecology
Abstract

WOS:000514971500002; International audience; The decrease in ocean pH that results from the increased concentration of dissolved carbon dioxide (CO2) is likely to influence many physiological functions in organisms. It has been shown in different fish species that ocean acidification (OA) mainly affects sensory systems, including olfaction. Impairment of olfactory function may be due to a dysfunction of the GABAergic system and to an alteration of neuronal plasticity in the whole brain and particularly in olfactory bulbs. Recent studies revealed that OA-driven effects on sensory systems are partly mediated by the regulation of the expression of genes involved in neurotransmission and neuronal development. However, these studies were performed in fish exposed to acidified waters for short periods, of only a few days. In the present paper, we investigated whether such effects could be observed in adult (4-years old) European sea bass (Dicentrarchus labrax) exposed to two hypercapnic and acidified conditions (PCO2 approximate to 980 mu atm; pH total = 7.7 and PCO2 approximate to 1520 mu atm; pH total = 7.5) from the larval stage. In a first approach, we analyzed by qPCR the expression of five genes involved in neurogenesis (DCX) or expressed in GABAergic (Gabra3), glutamatergic (Gria1) or dopaminergic (TH and DDC) neurons in the olfactory bulbs. The tested experimental conditions did not change the expression of any of the five genes. This result would indicate that a potential disruption of the olfactory function of sea bass exposed for a long term to near-future OA, either occurs at a level other than the transcriptional one or involves other actors of the sensory function. more...

Published
2019
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70. Psychological impacts of follow up for occupational asbestos exposure. Consequences after compensation for occupational disease in the SPP-A cohort

Author

Christophe Paris, Isabelle Thaon, Béatrice Clin, A. Gislard, D. Riblier-Dehen, Jean-Claude Pairon, Amandine Luc, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CHU Pontchaillou [Rennes], Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers (ANTICIPE), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Normandie Université (NU), CHU Rouen, Aliments Bioprocédés Toxicologie Environnements (ABTE), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Service de santé au travail et pathologie professionnelle [Rouen], Biomécanique cellulaire et respiratoire (BCR), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Intercommunal de Créteil (CHIC), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université de Lorraine (UL), Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-UNICANCER, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Centre Régional de Lutte contre le Cancer François Baclesse (CRLC François Baclesse ), Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Santé-Travail Paris-Est [Créteil], Université Paris-Est Créteil, Faculté de Médecine [Créteil] (UPEC-Médecine), and Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) more...

Subjects
Pulmonary and Respiratory Medicine, 030505 public health, Indemnisation, Asbestos, Amiante, Stress psychologique, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Psychological stress, Dépistage, [SDV.TOX]Life Sciences [q-bio]/Toxicology, Occupational diseases, Screening, Maladies professionnelles, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, 030212 general & internal medicine, 0305 other medical science, Compensation, ComputingMilieux_MISCELLANEOUS
Abstract

Resume Introduction En France, le suivi post-professionnel apres une exposition a l’amiante est recommande. Cette etude recherchait des consequences psychologiques a long terme, notamment en fonction de la reconnaissance d’une maladie professionnelle. Methodes Dans le cadre d’une etude sur le suivi post-professionnel amiante (SPP-A), les volontaires normands ont ete sollicites pour repondre a des auto-questionnaires concernant leur etat psychologique aux differentes etapes du suivi, incluant un questionnaire avant puis 6 mois et enfin 18 a 24 mois apres le scanner. Les informations recueillies aupres de 622 sujets ont ete comparees en fonction du resultat du depistage et de la reconnaissance d’une maladie professionnelle. Resultats La reconnaissance d’une maladie professionnelle est associee a une augmentation de la detresse psychologique a long terme. L’alteration de l’etat psychologique lors du suivi est plus importante chez les hommes declarant avoir une maladie professionnelle reconnue. La decouverte d’une pathologie en lien avec l’amiante lors du depistage est associee a une perception moins bonne de l’etat de sante general et a une augmentation de la detresse psychologique. Conclusion La reconnaissance d’une maladie professionnelle ne semble pas compenser l’impact psychologique negatif lie a la decouverte d’une pathologie liee a l’amiante lors du suivi post-professionnel. more...

Published
2019
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71. Lookalike and soundalike drugs: a potential cause of cutaneous adverse reactions to drugs

Author

P. Modiano, Colin J. Davis, Charles Cassius, D. Carre-Gislard, Bénédicte Lebrun-Vignes, Saskia Ingen-Housz-Oro, Olivier Chosidow, P Bravard, Hôpital Henri Mondor, University of Bristol [Bristol], Groupe Hospitalier du Havre Hôpital Jacques Monod (MONTIVILLIERS) (GHH), Hôpital Saint-Vincent de Paul, Service de Pharmacologie médicale [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Epidemiology in Dermatology and Evaluation in Therapeutics (EpiDermE), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Service de dermatologie [Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Centre d'Investigation Clinique Henri Mondor (CIC Henri Mondor), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), and VO, alexandra more...

Subjects
medicine.medical_specialty, Databases, Factual, business.industry, MEDLINE, Dermatology, [SDV.MHEP.DERM] Life Sciences [q-bio]/Human health and pathology/Dermatology, Mental Health Data Science, Pharmacovigilance, Medicine, Humans, Medication Errors, Physical and Mental Health, Drug Eruptions, France, business, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology, Drug Labeling, Retrospective Studies, Skin
Abstract

International audience; No abstract available

Published
2019
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72. Harnessing the power of next-generation sequencing technologies to the purpose of high-throughput pesticide resistance diagnosis

Author

Charles Poncet, Christophe Délye, Séverine Michel, Véronique Gautier, Fanny Pernin, Marie Gislard, Valérie Le Corre, Agroécologie [Dijon], Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Génétique Diversité et Ecophysiologie des Céréales (GDEC), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Génome et Transcriptome - Plateforme Génomique ( GeT-PlaGe), Plateforme Génome & Transcriptome (GET), Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Bayer CropScience France, ANSES via the system for monitoring the adverse effects of plant protection products, BASF SAS France, John Wiley & Sons, Chichester, Sussex, England, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), and Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) more...

Subjects
0106 biological sciences, Pesticide resistance, Resistance, Plant Weeds, Computational biology, Biology, 01 natural sciences, DNA sequencing, [SDV.GEN.GPL]Life Sciences [q-bio]/Genetics/Plants genetics, chemistry.chemical_compound, symbols.namesake, Illumina, Diagnosis, Humans, [INFO.INFO-BT]Computer Science [cs]/Biotechnology, Pesticides, Genotyping, Ambrosia artemisiifolia, Illumina dye sequencing, Sanger sequencing, High-Throughput Nucleotide Sequencing, General Medicine, Amplicon, biology.organism_classification, 010602 entomology, Acetolactate Synthase, chemistry, Insect Science, Mutation, symbols, Genotyping-by-sequencing, Herbicide, Agronomy and Crop Science, Acetolactate-synthase, DNA, 010606 plant biology & botany, Herbicide Resistance
Abstract

International audience; BACKGROUND Next Generation Sequencing (NGS) technologies offer tremendous possibilities for high-throughput pesticide resistance diagnosis via massive genotyping-by-sequencing. Herein, we used Illumina sequencing combined with a simple, non-commercial bioinformatics pipe-line to seek mutations involved in herbicide resistance in two weeds. RESULTS DNA was extracted from 96 pools of 50 plants for each species. Three amplicons encompassing 15 ALS (acetolactate-synthase) codons crucial for herbicide resistance were amplified from each DNA extract. Above 18 and 20 million quality 250-nucleotide sequence reads were obtained for groundsel (Senecio vulgaris, tetraploid) and ragweed (Ambrosia artemisiifolia, diploid), respectively. Herbicide resistance-endowing mutations were identified in 45 groundsel and in eight ragweed field populations. The mutations detected and their frequencies assessed by NGS were checked by individual plant genotyping or Sanger sequencing. NGS results were fully confirmed, except in three instances out of 12 where mutations present at a frequency of 1% were detected below the threshold set for reliable mutation detection. CONCLUSION Analyzing 9600 plants requested 192 DNA extractions followed by 1728 PCRs and two Illumina runs. Equivalent results obtained by individual analysis would have necessitated 9600 individual DNA extractions followed by 216 000 genotyping PCRs, or by 121 500 PCRs and 40 500 Sanger sequence runs. This clearly demonstrates the interest and power of NGS-based detection of pesticide resistance from pools of individuals for diagnosing resistance in massive numbers of individuals. (c) 2019 Society of Chemical Industry more...

Published
2019
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73. Interstitial Lung Abnormalities Detected by CT in Asbestos-Exposed Subjects Are More Likely Associated to Age

Author

Aude Lacourt, Bénédicte Clin, Gilbert Ferretti, A. Gislard, Pascal Andujar, Ilyes Benlala, Gaël Dournes, François Laurent, Fleur Delva, Céline Gramond, Jean-Claude Pairon, Isabelle Thaon, Christophe Paris, Patrick Brochard, Justine Gallet, Soizick Chamming's, CHU Bordeaux [Bordeaux], Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] (CRCTB), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut National de la Santé et de la Recherche Médicale (INSERM), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers (ANTICIPE), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM), Aliments Bioprocédés Toxicologie Environnements (ABTE), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), CHU Rouen, Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), CHU Henri Mondor, Institut Interuniversitaire de Médecine du Travail de Paris Ile-de-France (IIMTPIF), CHU Pontchaillou [Rennes], Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Centre Hospitalier Universitaire [Grenoble] (CHU), French National Health Insurance (Occupational Risk Prevention Department), French Ministry of Labour and Social Relations, French Agency for Food, Environmental and Occupational Health and Safety (ANSES) [07-CRD-51, EST 2006/1/43, EST 2009/68], Chard-Hutchinson, Xavier, CHU Henri Mondor [Créteil], Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-UNICANCER, Université d'Angers (UA)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) more...

Subjects
[SDV.MHEP.AHA] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], medicine.medical_specialty, asbestosis, Asbestosis, Population, Cumulative Exposure, medicine.disease_cause, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Article, Asbestos, Pulmonary function testing, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, [SDV.MHEP.AHA]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], [SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health, Medicine, 030212 general & internal medicine, education, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, education.field_of_study, Lung, business.industry, General Medicine, respiratory system, medicine.disease, asbestos-exposition, 3. Good health, medicine.anatomical_structure, 030228 respiratory system, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Cohort, HRCT, [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Population study, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business
Abstract

Objective: the aim of this study was to evaluate the association between interstitial lung abnormalities, asbestos exposure and age in a population of retired workers previously occupationally exposed to asbestos. Methods: previously occupationally exposed former workers to asbestos eligible for a survey conducted between 2003 and 2005 in four regions of France, underwent chest CT examinations and pulmonary function testing. Industrial hygienists evaluated asbestos exposure and calculated for each subject a cumulative exposure index (CEI) to asbestos. Smoking status information was also collected in this second round of screening. Expert radiologists performed blinded independent double reading of chest CT-scans and classified interstitial lung abnormalities into: no abnormality, minor interstitial findings, interstitial findings inconsistent with UIP, possible or definite UIP. In addition, emphysema was assessed visually (none, minor: emphysema &lt, 25%, moderate: between 25 and 50% and severe: &gt, 50% of the lung). Logistic regression models adjusted for age and smoking were used to assess the relationship between interstitial lung abnormalities and occupational asbestos exposure. Results: the study population consisted of 2157 male subjects. Interstitial lung abnormalities were present in 365 (16.7%) and emphysema in 444 (20.4%). Significant positive association was found between definite or possible UIP pattern and age (OR adjusted =1.08 (95% CI: 1.02–1.13)). No association was found between interstitial abnormalities and CEI or the level of asbestos exposure. Conclusion: presence of interstitial abnormalities at HRCT was associated to aging but not to cumulative exposure index in this cohort of former workers previously occupationally exposed to asbestos. more...

Published
2021
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74. In vitro shared transcriptomic responses of Aedes aegypti to arboviral infections: Example of dengue and Rift Valley fever viruses

Author

Licciardi, Séverine, Loire, Etienne, Cardinale, Eric, Gislard, Marie, Dubois, Emeric, Cetre-Sossah, Catherine, Licciardi, Séverine, Loire, Etienne, Cardinale, Eric, Gislard, Marie, Dubois, Emeric, and Cetre-Sossah, Catherine more...

Abstract

Background: Arthropod borne virus infections are the cause of severe emerging diseases. Among the diseases due to arboviruses, dengue (DEN) and Rift Valley fever (RVF) are in the top ten in the list of diseases responsible of severe human cases worldwide. Understanding the effects of viral infection on gene expression in competent vectors is a challenge for the development of early diagnostic tools and may enable researchers and policy makers to better anticipate outbreaks in the next future. Methods: In this study, alterations in gene expression across the entire Aedes aegypti genome during infection with DENV and RVFV were investigated in vitro at two time points of infection, the early phase (24 h) and the late phase (6 days) of infection using the RNA sequencing approach Results: A total of 10 upregulated genes that share a similar expression profile during infection with both viruses at early and late phases of infection were identified. Family B and D clip-domain serine proteases (CLIP) were clearly overrepresented as well as C-type lectins and transferrin. Conclusions: Our data highlight the presence of 10 viral genes upregulated in Ae. aegypti during infection. They may also be targeted in the case of the development of broad-spectrum anti-viral diagnostic tools focusing the mosquito vectors rather than the mammalian hosts as they may predict the emergence of outbreaks. more...

Published
2020

75. Évaluation médico-économique d’un programme de dépistage des cancers broncho-pulmonaires chez des sujets exposés à l’amiante

Author

Helene Goussault, François Laurent, Christos Chouaid, Bénédicte Clin, Aude Lacourt, S. Gendarme, Pascal Andujar, C. Paris, A. Gislard, Jean-Claude Pairon, Céline Gramond, Patrick Brochard, and S. Chamming's more...

Subjects
Pulmonary and Respiratory Medicine, 03 medical and health sciences, 0302 clinical medicine, 030212 general & internal medicine, 030204 cardiovascular system & hematology
Abstract

Introduction Les Resultats de l’etude NLST aux Etats-Unis et de l’etude NELSON en Europe ont ouvert le debat sur l’opportunite d’un depistage du cancer broncho-pulmonaire (CBP) chez des patients exposes a des carcinogenes respiratoires [1] , [2] . L’objectif de cette analyse est d’evaluer l’impact medico-economique, en France, de la mise en place d’un programme de depistage du CBP dans une cohorte de sujets exposes a l’amiante. Methodes L’analyse est basee sur une modelisation MCMC (Monte Carlo Markok Chain) permettant d’etablir le rapport cout utilite de la mise en place d’un depistage annuel du CBP par tomodensitometrie thoracique chez des sujets fumeurs et exposes fortement a l’amiante. Les donnees utilisees dans la modelisation sont l’incidence de CBP dans la cohorte francaise ARDCO (cohorte multiregionale de sujets exposes a l’amiante avec suivi longitudinal depuis 2002), et leurs consommations de soins, les parametres d’intervention sont issus de l’etude NLST. Les donnees d’utilites et de couts de prise en charge des CBP diagnostiques sont issues de la litterature. Une analyse de sensibilite a permis d’evaluer differentes strategies de depistage selon l’intervalle entre les scanners et la population cible. Resultats La mise en place d’un depistage annuel par TDM thoracique chez les sujets fumeurs et exposes fortement a l’amiante permet un gain de QALY de 0.041 par personne [IC 95 % 0.028–0.052] pour un cout de 6208 € par personne [IC 95 % 4536€–7904€], soit un ratio cout-utilite differentiel de 93 020 €/QALY [IC 95 % 51 898€–170 492€]. Lorsque le depistage repose sur un scanner tous les 2 ans, le rapport cout-utilite est plus favorable: 40 938 €/QALY [IC 95 % 22 440€–65 364€]. Conclusion Au regard des seuils habituels pour une intervention de sante, un depistage du CBP par TDM thoracique tous les 2 ans est acceptable et preferable a un depistage annuel dans cette population. more...

Published
2021
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76. Segmentation of amyloid-β plaques in three mouse models of Alzheimer’s disease using X-ray phase contrast-computed tomography

Author

Coralie Gislard, Carlie Boisvert, Cécile Olivier, Françoise Peyrin, Marlene Wiart, Hervé Boutin, Hugo Rositi, Fabien Chauveau, Imagerie Tomographique et Radiothérapie, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Wolfson Molecular Imaging Centre (WMIC), University of Manchester [Manchester], Institut Pascal (IP), SIGMA Clermont (SIGMA Clermont)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Radiopharmaceutical and Neurochemical Biomarkers (BIORAN), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Institut Pascal - Clermont Auvergne (IP), Sigma CLERMONT (Sigma CLERMONT)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Radiopharmaceutical and Neurochemical Biomarkers Team (BioRaN), Université de Lyon, Centre de recherche en neurosciences de Lyon (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National de la Recherche Agronomique (INRA), and Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL) more...

Subjects
[INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, [SDV.IB]Life Sciences [q-bio]/Bioengineering, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], [CHIM.RADIO]Chemical Sciences/Radiochemistry, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

77. Inequities in occupational diseases recognition in France

Author

S. Letalon, L. Rollin, Jean-François Gehanno, A. Gislard, Laboratoire d'Informatique Médicale et Ingénierie des Connaissances en e-Santé (LIMICS), Université Paris 13 (UP13)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Service de santé au travail et pathologie professionnelle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Aliments Bioprocédés Toxicologie Environnements (ABTE), and Université de Caen Normandie (UNICAEN) more...

Subjects
Male, medicine.medical_specialty, Epidemiology, Acceptance rate, Occupational disease, Occupational Health Services, Occupational physicians, 030501 epidemiology, Injustice, Health Services Accessibility, 03 medical and health sciences, Évaluation de processus en soins de santé, medicine, Workers’ Compensation, Maladies professionnelles, Humans, Ethics, Medical, Healthcare Disparities, Asbestos-related diseases, Aged, Ethics, Process Assessment (Health Care), Geography, business.industry, Compensation (psychology), Comparability, Public Health, Environmental and Occupational Health, Middle Aged, medicine.disease, Quarter (United States coin), 3. Good health, Occupational Diseases, Socioeconomic Factors, Indemnisation des accidentés du travail, Family medicine, [SDV.TOX]Life Sciences [q-bio]/Toxicology, Workers' Compensation, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, France, 0305 other medical science, business, Éthique
Abstract

Background In France, complex cases of occupational disease (OD) are submitted to regional committees who are in charge of accepting, or rejecting, the claim. Their mean annual acceptance rate varies from one region to another, which may reflect differences in the cases, or discrepancies between committees. The objective of this study was to assess the comparability of the decisions of the committees on the basis of standardized cases. Methods Three experienced occupational physicians specialized in OD were asked to develop 28 clinical cases representative of claims for compensation usually seen in these committees. The cases, in the form of short vignettes, were submitted to the 18 French regional committees, asking if they would recognise each case as an OD. Results All committees participated. The acceptance rate (recognition of the case as an OD) varied, ranging from 18% to 70%. All the committees took the same decision for only 7 out of the 28 cases, but half accepted and half refused for 3 cases. For 10 cases, one quarter of the committees gave a decision different than the other 75%. The highest discordance rates were observed for the cases concerning musculoskeletal disorders and asbestos related diseases. Conclusion The committees take very different decisions in terms of recognition of OD, especially for the most frequently compensated OD in France, i.e. musculoskeletal disorders and asbestos related diseases. This is a major source of injustice for the employees who seek compensation and there is a need to develop methods to harmonize decisions between committees. more...

Published
2019
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78. Additional file 5: of Effect of paleopolyploidy and allopolyploidy on gene expression in banana

Author

Cenci, Alberto, Hueber, Yann, Zorrilla-Fontanesi, Yasmin, Wesemael, Jelle, Ewaut Kissel, Gislard, Marie, Sardos, Julie, Swennen, Rony, Roux, Nicolas, Carpentier, Sebastien, and Rouard, Mathieu

Abstract

Sample of genes differentially expressed in ‘Cachaco’ (ABB) compared to AAA cultivars (‘Mbwazirume’ and ‘Grande Naine’). (DOCX 18 kb)

Published
2019
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79. Both anti-inflammatory and antiviral properties of novel drug candidate ABX464 are mediated by modulation of RNA splicing

Author

Aude Garcel, Didier Scherrer, Jamal Tazi, Noëlie Campos, J Hartmut Ehrlich, Roman Bruno, Laure Lapasset, Abdelhamid Mahdi Laaref, Emeric Dubois, Marie Gislard, Laurent Manchon, Audrey Vautrin, Abivax, Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Laboratoire de virologie du Centre de Recherches du Service de Santé des Armées (CRSSA), Ministère de la Défense, Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Institut de Génomique Fonctionnelle - Montpellier GenomiX (IGF MGX), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Laboratoire pharmaceutique, Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-BioCampus (BCM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and MANCHON, Laurent more...

Subjects
0301 basic medicine, Anti-HIV Agents, [SDV]Life Sciences [q-bio], RNA Splicing, Anti-Inflammatory Agents, lcsh:Medicine, Biology, Virus, Article, 03 medical and health sciences, 0302 clinical medicine, RNA interference, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, lcsh:Science, Gene, ComputingMilieux_MISCELLANEOUS, Cells, Cultured, [SDV.BIBS] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Multidisciplinary, Cap binding complex, Sequence Analysis, RNA, lcsh:R, Intron, RNA, HIV, High-Throughput Nucleotide Sequencing, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Long non-coding RNA, 3. Good health, [SDV] Life Sciences [q-bio], MicroRNAs, 030104 developmental biology, Gene Expression Regulation, RNA splicing, Cancer research, Leukocytes, Mononuclear, Quinolines, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], RNA, Viral, lcsh:Q, 030217 neurology & neurosurgery, HeLa Cells
Abstract

ABX464 is a first-in-class, clinical-stage, small molecule for oral administration that has shown strong anti-inflammatory effects in the DSS-model for inflammatory bowel disease (IBD) and also prevents replication of the HIV virus. ABX464 which binds to cap binding complex (CBC) has demonstrated safety and efficacy in a phase 2a proof-of-concept clinical trial in patients with Ulcerative colitis. Previously, with limited technologies, it was not possible to quantify the effect of ABX464 on viral and cellular RNA biogenesis. Here, using RNA CaptureSeq and deep sequencing, we report that ABX464 enhances the splicing of HIV RNA in infected PBMCs from six healthy individuals and also the expression and splicing of a single long noncoding RNA to generate the anti-inflammatory miR-124 both ex vivo and in HIV patients. While ABX464 has no effect on pre-mRNA splicing of cellular genes, depletion of CBC complex by RNAi leads to accumulation of intron retention transcripts. These results imply that ABX464 did not inhibit the function of CBC in splicing but rather strengthens it under pathological condition like inflammation and HIV infection. The specific dual ability of ABX464 to generate both anti-inflammatory miR-124 and spliced viral RNA may have applicability for the treatment of both inflammatory diseases and HIV infection. more...

Published
2019
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80. Additional file 2: of Effect of paleopolyploidy and allopolyploidy on gene expression in banana

Author

Cenci, Alberto, Hueber, Yann, Zorrilla-Fontanesi, Yasmin, Wesemael, Jelle, Ewaut Kissel, Gislard, Marie, Sardos, Julie, Swennen, Rony, Roux, Nicolas, Carpentier, Sebastien, and Rouard, Mathieu

Abstract

Chromosome intervals (defined on genes coordinates) showing B:A ratio deviating from the expected genomic constitution. CDM indicates the three cultivars sharing the same pattern of deviating regions (‘Cachaco’, ‘Dole’ and ‘Monthan’). (DOCX 16 kb) more...

Published
2019
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81. Additional file 6: of Effect of paleopolyploidy and allopolyploidy on gene expression in banana

Author

Cenci, Alberto, Hueber, Yann, Zorrilla-Fontanesi, Yasmin, Wesemael, Jelle, Ewaut Kissel, Gislard, Marie, Sardos, Julie, Swennen, Rony, Roux, Nicolas, Carpentier, Sebastien, and Rouard, Mathieu

Abstract

Histograms representing the paralog included expression (normalized read count, Y axis) for 58 genes having significant higher expression in ‘Cachaco’ (Ca) than in ‘Grande Naine’ (GN) and ‘Mbwazirume’ (Mb). Blue color represents expression level of DEG, other colors expression level of respective paralogs. (PPTX 146 kb) more...

Published
2019
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83. 3-Dimensional Quantification of Composite Pleural Plaque Volume in Patients Exposed to Asbestos Using High-resolution Computed Tomography: A Validation Study

Author

Jean-Claude Pairon, Ilyes Benlala, Bénédicte Clin, François Laurent, Christophe Paris, Gaël Dournes, Antoine Gislard, Fabien Baldacci, Aude Lacourt, Adrian Dubois, Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] (CRCTB), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut National de la Santé et de la Recherche Médicale (INSERM), CIC Bordeaux, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Cancer environnement (EPICENE ), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), Université Bordeaux Segalen - Bordeaux 2, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CHU Pontchaillou [Rennes], CHU Rouen, Normandie Université (NU), Aliments Bioprocédés Toxicologie Environnements (ABTE), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Service de santé au travail et pathologie professionnelle [Rouen], Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers (ANTICIPE), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-UNICANCER, Biomécanique cellulaire et respiratoire (BCR), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Bordelais de Recherche en Informatique (LaBRI), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Bordeaux (UB)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Centre National de la Recherche Scientifique (CNRS) more...

Subjects
Pulmonary and Respiratory Medicine, Male, Validation study, High-resolution computed tomography, [SDV]Life Sciences [q-bio], Pleural plaque, 030204 cardiovascular system & hematology, medicine.disease_cause, Asbestos, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Imaging, Three-Dimensional, medicine, Humans, Radiology, Nuclear Medicine and imaging, Mesothelioma, Lung cancer, ComputingMilieux_MISCELLANEOUS, Aged, Retrospective Studies, Reproducibility, medicine.diagnostic_test, business.industry, Reproducibility of Results, respiratory system, Pleural Diseases, medicine.disease, Plaque, Atherosclerotic, respiratory tract diseases, 3. Good health, [SDV.TOX]Life Sciences [q-bio]/Toxicology, Female, Tomography, Chest imaging, Nuclear medicine, business, Tomography, X-Ray Computed
Abstract

As pleural plaque has been reported as a risk factor in the occurrence of lung cancer and mesothelioma, a reproducible and precise method of measurement of pleural plaque volume (PPV) is needed to further describe these relationships. The aim of the study was to assess the reproducibility of a 3-dimensional computed tomography (3D-CT) volumetric analysis of PPV in patients with occupational exposure to asbestos.A total of 28 patients were retrospectively randomly selected from the multicenter APEXS (Asbestos Post Exposure Survey) study, which was held between 2003 and 2005. All patients underwent a 3D-CT scan. Two readers specialized in chest radiology completed the 3D semiautomated quantification of lung volume using dedicated software. They also had to categorize the visual extent of pleural plaque in terms of thickness and circumference. Reproducibility of the continuous PPV variable was assessed using the intraclass correlation coefficient (ICC) and Bland-Altman analysis. Reproducibility of categorical variables was assessed using the κ test.Intraobserver reproducibility of PPV was almost perfect (ICC=0.98 [95% interval: 0.97-0.99]), and interobserver reproducibility was very good (ICC=0.93 [0.88-0.97]). At Bland-Altman analysis, the mean differences were 0.1 (limit of agreement: -11.0 to 11.2) and 3.7 cc (-17.8 to 25.2), respectively. Visual analysis of both plaque in terms of thickness and circumference were fair to moderate, with κ values ranging from 0.30 to 0.60.3D semiautomatic quantification of PPV is feasible and reproducible using CT in patients with occupational exposure to asbestos. PPV measurement may be useful to correlate with other asbestos-related disease outcomes and prognosis. more...

Published
2018
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84. Effect of paleopolyploidy and allopolyploidy on gene expression in banana

Author

Sebastien Carpentier, Nicolas Roux, Jelle van Wesemael, Julie Sardos, Ewaut Kissel, Yasmín Zorrilla-Fontanesi, Rony Swennen, Yann Hueber, Marie Gislard, Alberto Cenci, and Mathieu Rouard

Subjects
0106 biological sciences, lcsh:QH426-470, lcsh:Biotechnology, Biology, 01 natural sciences, Genome, Plant Roots, Banana, Polyploidy, 03 medical and health sciences, Genome structure, Gene Expression Regulation, Plant, lcsh:TP248.13-248.65, Musa acuminata, Gene expression, Genetics, Transcriptomics, Gene, Phylogeny, 030304 developmental biology, Plant Proteins, 0303 health sciences, Likelihood Functions, Gene Expression Profiling, Paralogs, fungi, food and beverages, Musa, biology.organism_classification, Phenotype, lcsh:Genetics, Paleopolyploidy, Ploidy, DNA microarray, Genome, Plant, Metabolic Networks and Pathways, 010606 plant biology & botany, Biotechnology, Research Article
Abstract

Background Bananas (Musa spp.) are an important crop worldwide. Most modern cultivars resulted from a complex polyploidization history that comprised three whole genome duplications (WGDs) shaping the haploid Musa genome, followed by inter- and intra-specific crosses between Musa acuminata and M. balbisiana (A and B genome, respectively). Unresolved hybridizations finally led to banana diversification into several autotriploid (AAA) and allotriploid cultivars (AAB and ABB). Using transcriptomic data, we investigated the impact of the genome structure on gene expression patterns in roots of 12 different triploid genotypes covering AAA, AAB and ABB subgenome constitutions. Results We demonstrate that (i) there are different genome structures, (ii) expression patterns go beyond the predicted genomic groups, and (iii) the proportion of the B genome influences the gene expression. The presence of the B genome is associated with a higher expression of genes involved in flavonoid biosynthesis, fatty acid metabolism, amino sugar and nucleotide sugar metabolism and oxidative phosphorylation. There are cultivar-specific chromosome regions with biased B:A gene expression ratios that demonstrate homoeologous exchanges (HE) between A and B sub-genomes. In two cultivars, aneuploidy was detected. We identified 3674 genes with a different expression level between allotriploid and autotriploid with ~ 57% having recently duplicated copies (paralogous). We propose a Paralog Inclusive Expression (PIE) analysis that appears to be suitable for genomes still in a downsizing and fractionation process following whole genome duplications. Our approach allows highlighting the genes with a maximum likelihood to affect the plant phenotype. Conclusions This study on banana is a good case to investigate the effects of alloploidy in crops. We conclude that allopolyploidy triggered changes in the genome structure of a crop and it clearly influences the gene. Electronic supplementary material The online version of this article (10.1186/s12864-019-5618-0) contains supplementary material, which is available to authorized users. more...

Published
2018

85. Innovation Procurement Procedure Selection Report

Author

Bougrain F, Gislard AC, JD, Badia, Balasko-Kis, M, Flori P, Kuharic B, Madramany-Sanchis P, Maio B, Martins S, Navarro-Jover JM, Nunes E, Pacheco P, Premec D, Ribes-Greus A, Serrano-Cantó I, Simic I, and Mattioli D more...

Subjects
public procurement of innovation, energy efficiency, green growth
Abstract

The aim of this document is to illustrate with four case studies the key steps to design and implement an innovation procurement process. These demonstration sites will exemplify the process to follow and the pitfalls to avoid. Four municipalities involved in PROMINENT-MED launched PPI for the renovation of their public building: The municipality of Alzira in Spain: the pilot project focuses on the refurbishment of an old (1891) orange storage building (“magatzem de cucó”); The municipality of Koprivnica in Croatia: the pilot project involves the energy efficient renovation of a prefabricated kindergarten building. The municipality of Mértola: the pilot project concerns the renovation of the city hall that also hosts the Roman part of Mértola’s museum. The municipality of Narni in Italy: the pilot case is applied for the refurbishment of a kindergarten hosting children from 6 to 36 months. The organisation of each municipality and the continuity of each pilot project, from needs identification to the assessment of the project performance, will be presented to show how small municipalities prepared and implemented PPI. This guidance will present the following steps in the public procurement of innovation process: Needs identification and assessment; Market engagement; The business case PPI broker / external facilitator Open market consultation, Prominent MED project (Public Procurement of Innovation Boosting Green Growth in the MED area, 1MED15-1.1-M12-070) Interreg Mediterranean, Project co-financed by the European Regional Development Fund. DOI: 10.5281/zenodo.4250528 more...

Published
2018
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86. Liens entre cancer de l’œsophage et exposition professionnelle à l’amiante : étude au sein de la cohorte ARDCo

Author

Soizick Chamming's, Patrick Brochard, Isabelle Thaon, Mathilde Boulanger, Aude Lacourt, Jean-Claude Pairon, Bénédicte Clin, Amandine Luc, Christophe Paris, Guy Ogier, Antoine Gislard, Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers (ANTICIPE), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-UNICANCER, Centre de consultations de pathologies professionnelles [CHRU Nancy] (CCPP), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Interactions Gènes-Risques environnementaux et Effets sur la Santé (INGRES), Université de Lorraine (UL), and Institut Interuniversitaire de Médecine du Travail de Paris Ile-de-France (IIMTPIF) more...

Subjects
030506 rehabilitation, 03 medical and health sciences, 0302 clinical medicine, Public Health, Environmental and Occupational Health, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, 0305 other medical science, 030210 environmental & occupational health, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, ComputingMilieux_MISCELLANEOUS, 3. Good health
Abstract

Contexte L’association eventuelle entre l’exposition professionnelle a l’amiante et le cancer de l’œsophage demeure actuellement controversee, comme en temoigne l’evaluation du Centre international de recherche sur le cancer (CIRC) realisee en 2012. La question du lien eventuel entre ce cancer et l’exposition a l’amiante est cependant tres importante, tant en matiere de surveillance medicale des sujets exposes, qu’en matiere de reparation medico-legale des patients presentant ce type de pathologie. Objectif L’objectif de notre etude est d’analyser l’incidence et la mortalite par cancer de l’œsophage dans une cohorte de sujets ayant ete exposes professionnellement a l’amiante (cohorte ARDCo : « Asbestos-Related Diseases Cohort »). Methode Un suivi sur 10 ans de 14 515 hommes inclus dans le programme ARDCo entre octobre 2003 et decembre 2005 a ete realise. L’exposition a l’amiante a ete analysee par des hygienistes industriels a partir des donnees issues d’un questionnaire standardise adresse aux sujets eligibles. Les variables utilisees pour caracteriser cette exposition a l’amiante ont associe : la duree d’exposition a l’amiante, un indice d’exposition cumulee a l’amiante (IEC) et la latence (delai entre le debut de l’exposition et l’apparition des premiers symptomes de la maladie). Une analyse statistique des associations entre les variables d’exposition a l’amiante et, d’une part, l’incidence du cancer de l’œsophage et, d’autre part, la mortalite par cancer de l’œsophage, a ete realisee a l’aide d’un modele de Cox, avec ajustement sur le statut tabagique, la latence et l’IEC (exprime en Ln (IEC + 1)). Resultats Nous avons mis en evidence une relation dose-effet significative entre l’IEC a l’amiante et le cancer de l’œsophage, a la fois en incidence et en mortalite. Conclusion Cette vaste etude est en faveur d’une relation entre l’exposition a l’amiante et le cancer de l’œsophage. more...

Published
2018
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87. Report on international technical events

Author

Bougrain F, Gislard AC, Badia JD, Madramany-Sanchís P, Martins S, Nunes E, Ribes-Greus A, Whyles G, and Mattioli D

Subjects
Energy efficiency, Green growth, health care facilities, manpower, and services, education, health care economics and organizations, Public Procurement of Innovation
Abstract

Report on international technical events, Prominent MED project (Public Procurement of Innovation Boosting Green Growth in the MED area, 1MED15-1.1-M12-070) Interreg Mediterranean, Project co-financed by the European Regional Development Fund. more...

Published
2018
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88. Guidance for innovation procurement selection

Author

Bougrain F, Gislard AC, Badia JD, Balasko M, Flori P, Horvatic I, Kuharic B, Madramany-Sanchis P, Maio B, Martins S, Navarro-Jover JM, Nunes E, Pacheco P, Premec D, Ribes-Greus A, Serrano-Cantó I, Simic I, Teruel-Juanes R, and Mattioli D more...

Subjects
Energy Efficiency, Public Procurement of Innovation, Green Growth
Abstract

The aim of these guidelines is to lessen these traditional barriers faced by local authorities and to help them in adopting innovation procurement practices. It will present the key steps to design and implement an innovation procurement process. Four municipalities involved in PROMINENT-MED launched PPI for the renovation of their public building: • The municipality of Alzira in Spain: the pilot project focuses on the refurbishment of an old (1891) orange storage building (“magatzem de cucó”); • The municipality of Koprivnica in Croatia: the pilot project involves the energy efficient renovation of a prefabricated kindergarten building. • The municipality of Mértola: the pilot project concerns the renovation of the city hall that also hosts the Roman part of Mértola’s museum. • The municipality of Narni in Italy: the pilot case is applied for the refurbishment of a kindergarten hosting children from 6 to 36 months. The objectives of this guidance which is addressed to public authorities and small municipalities, is to provide a comprehensive overview of the key steps to follow in order to implement an innovation procurement process. The guidelines will not only be a step by step approach to innovation procurement, it will also outline the specificities of small public authorities and the peculiarities of the renovation projects., Prominent MED project (Public Procurement of Innovation Boosting Green Growth in the MED area, 1MED15-1.1-M12-070) Interreg Mediterranean, Project co-financed by the European Regional Development Fund. DOI: 10.5281/zenodo.4250528 more...

Published
2018
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89. 3-Dimensional Quantification of Composite Pleural Plaque Volume in Patients Exposed to Asbestos Using High-resolution Computed Tomography

Author

Dournes, Gael, primary, Dubois, Adrian, additional, Benlala, Ilyes, additional, Lacourt, Aude, additional, Paris, Christophe, additional, Gislard, Antoine, additional, Clin, Benedicte, additional, Pairon, Jean-Claude, additional, Baldacci, Fabien, additional, and Laurent, François, additional more...

Published
2019
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93. Brain virtual histology with X-ray phase-contrast tomography Part II:3D morphologies of amyloid-β plaques in Alzheimer’s disease models

Author

Chourrout, Matthieu, Roux, Margaux, Boisvert, Carlie, Gislard, Coralie, Legland, David, Arganda-Carreras, Ignacio, Olivier, Cécile, Peyrin, Françoise, Boutin, Hervé, Rama, Nicolas, Baron, Thierry, Meyronet, David, Brun, Emmanuel, Rositi, Hugo, Wiart, Marlène, and Chauveau, Fabien more...

Abstract

While numerous transgenic mouse strains have been produced to model the formation of amyloid-β (Aβ) plaques in the brain, efficient methods for whole-brain 3D analysis of Aβ deposits have to be validated and standardized. Moreover, routine immunohistochemistry performed on brain slices precludes any shape analysis of Aβ plaques, or require complex procedures for serial acquisition and reconstruction. The present study shows how in-line (propagation-based) X-ray phase-contrast tomography (XPCT) combined with ethanol-induced brain sample dehydration enables hippocampus-wide detection and morphometric analysis of Aβ plaques. Performed in three distinct Alzheimer mouse strains, the proposed workflow identified differences in signal intensity and 3D shape parameters: 3xTg displayed a different type of Aβ plaques, with a larger volume and area, greater elongation, flatness and mean breadth, and more intense average signal than J20 and APP/PS1. As a label-free non-destructive technique, XPCT can be combined with standard immunohistochemistry. XPCT virtual histology could thus become instrumental in quantifying the 3D spreading and the morphological impact of seeding when studying prion-like properties of Aβ aggregates in animal models of Alzheimer’s disease. This is Part II of a series of two articles reporting the value of in-line XPCT for virtual histology of the brain; Part I shows how in-line XPCT enables 3D myelin mapping in the whole rodent brain and in human autopsy brain tissue. more...

Published
2022

94. Guide pour la sélection des achats innovants

Author

Bougrain F, Gislard AC, Badia JD, Balasko M, Flori P, Horvatic I, Kuharic B, Madramany-Sanchis P, Maio B, Martins S, Navarro Jover JM, Nunes E, Pacheco P, Premec D, Ribes-Greus A, Serrano-Cantó I, Simic I, Teruel-Juanes R, and Mattioli D more...

Subjects
Efficacité énergétique, Achat public d'innovation, Croissance verte
Abstract

Ce guide a pour but de réduire les obstacles auxquels se heurtent traditionnellement les collectivités locales et de leur permettre de mettre en place des pratiques d’achat innovant. Il présente les principales étapes de la conception et de la mise en œuvre d’un processus d’achat innovant. Quatre municipalités participant au projet Prominent-MED ont mis en place un PPI pour la rénovation de leurs bâtiments publics : • La municipalité d’Alzira en Espagne : le projet pilote porte sur la rénovation d’un ancien entrepôt d’oranges (1891) (« magatzem de cucó »). • La municipalité de Koprivnica en Croatie : le projet pilote porte sur la rénovation énergétique d’une école maternelle en préfabriqué. • La municipalité de Mértola : le projet pilote porte sur la rénovation de l’hôtel de ville qui abrite également la partie romaine du musée de Mértola. • La municipalité de Narni en Italie : le projet pilote porte sur la rénovation d’un jardin d’enfants accueillant des enfants de 6 à 36 mois. Ce guide s’adresse aux pouvoirs publics et aux petites municipalités. Il a pour but de présenter une vue d’ensemble exhaustive des principales étapes à suivre pour mettre en œuvre un processus d’achat innovant. Outre les étapes successives du processus d’achat innovant, le guide met l’accent sur les spécificités des petites collectivités publiques et sur les particularités des projets de rénovation., Prominent MED projet (Public Procurement of Innovation Boosting Green Growth in the MED area, 1MED15-1.1-M12-070) Interreg Mediterranean, Projet cofinancé par le Fonds européen de développement régional more...

Published
2017
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95. Inter-reader agreement in HRCT detection of pleural plaques and asbestosis in participants with previous occupational exposure to asbestos

Author

Gilbert Ferretti, Yasmina Badachi, Antoine Gislard, Marc Letourneux, Adrien Jankowski, Catherine Beigelman, Jean-Claude Pairon, Valérie Latrabe, François Laurent, Patrick Brochard, Michel Montaudon, Jacques Ameille, Evelyne Schorle, Bénédicte Clin, Amandine Luc, and Christophe Paris more...

Subjects
medicine.medical_specialty, Cross-sectional study, Health Personnel, Asbestosis, medicine.disease_cause, Asbestos, Informed consent, Occupational Exposure, medicine, Humans, Diagnostic Errors, Asbestos-related diseases, Aged, business.industry, Public Health, Environmental and Occupational Health, Ethics committee, Middle Aged, Pleural Diseases, medicine.disease, Fibrosis, Surgery, Cross-Sectional Studies, Cohort, Pleura, Occupational exposure, Radiology, Tomography, X-Ray Computed, business
Abstract

Objectives To investigate inter-reader agreement for the detection of pleural and parenchymal abnormalities using CT in a large cross-sectional study comprising information on individual cumulative exposure to asbestos. Methods The project was approved by the hospital ethics committee, and all patients received information on the study and gave their written informed consent. In 5511 CT scans performed in a cohort of retired workers previously exposed to asbestos and volunteering to participate in a multiregional survey programme (Asbestos Related Diseases Cohort, ARDCO), double randomised standardised readings, triple in case of disagreement, were performed by seven trained expert radiologists specialised in thoracic imaging and blind to the initial interpretation. Inter-reader agreement was evaluated by calculating the κ-weighted coefficient between pairs of expert readers and results of routine practice and final diagnosis after expert reading. Results κ-Weighted coefficients between trained experts ranged from 0.28 to 0.52 (fair to good), 0.59 to 0.86 (good to excellent) and 0.11 to 0.66 (poor to good) for the diagnosis of asbestosis, pleural plaques and fibrosis of the visceral pleura, respectively. κ-Weighted coefficients between results of routine practice and final diagnosis after expert reading were 0.13 (poor), 0.53 (moderate) and 0.11 (poor) for the diagnosis of asbestosis, pleural plaques and fibrosis of the visceral pleura, respectively. Conclusions Interpretation of benign asbestos-related thoracic abnormalities requires standardisation of the reading and trained readers, particularly for participants asking for compensation, and with a view to the longitudinal survey of asbestos-exposed workers. more...

Published
2014
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97. Liens entre cancer de l’œsophage et exposition professionnelle à l’amiante : étude au sein de la cohorte ARDCo

Author

Clin, Bénédicte, primary, Thaon, Isabelle, additional, Boulanger, Mathilde, additional, Brochard, Patrick, additional, Chamming's, Soizick, additional, Gislard, Antoine, additional, Lacourt, Aude, additional, Luc, Amandine, additional, Ogier, Guy, additional, Paris, Christophe, additional, and Pairon, Jean-Claude, additional more...

Published
2018
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98. Attention au plastique recyclé !

Author

Bouteiller, J., primary, Kunst, A., additional, Bauvin, O., additional, Lesueur, N., additional, Gislard, A., additional, Gehanno, J.F., additional, Joly, P., additional, and Tetart, F., additional

Published
2018
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99. Occupational Asbestos Exposure and Incidence of Colon and Rectal Cancers in French Men: The Asbestos-Related Diseases Cohort (ARDCo-Nut)

Author

Christophe Paris, Pilar Galan, Fabrice Herin, Pascal Wild, Patrick Brochard, Serge Hercberg, Gaëlle Coureau, Aude Lacourt, Soizick Chamming's, Jean-Claude Pairon, Isabelle Thaon, Bénédicte Clin, Pascal Andujar, Amandine Luc, Antoine Gislard, Interactions Gènes-Risques environnementaux et Effets sur la Santé (INGRES), Université de Lorraine (UL), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Cancers et préventions, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), Service de Santé au Travail et Pathologie Professionnellel [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Cancer environnement (EPICENE ), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Bordeaux [Bordeaux], Institut Interuniversitaire de Médecine du Travail de Paris Ile-de-France (IIMTPIF), Service de santé au travail et pathologie professionnelle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Aliments Bioprocédés Toxicologie Environnements (ABTE), Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Paris 13 (UP13)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Direction Scientifique (DS), Institut national de recherche et de sécurité (Vandoeuvre lès Nancy) (INRS ( Vandoeuvre lès Nancy)), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Service des Maladies Professionnelles et Environnementales, Université Fédérale Toulouse Midi-Pyrénées-Centre hospitalier universitaire de Toulouse - CHU Toulouse, Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'investigation clinique et d'épidémiologie clinique 7 (CIC-EC7), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut Bergonié - CRLCC Bordeaux-Institut National de la Santé et de la Recherche Médicale (INSERM)-Cancéropôle du Grand Sud-Ouest, Registre Général des Cancers de la Gironde, Université Bordeaux Segalen - Bordeaux 2-Institut Bergonié - CRLCC Bordeaux-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED), Service de Médecine du Travail et de Pathologies Professionnelles, CHU Bordeaux [Bordeaux]-Hôpital Pellegrin, Institut Interuniversitaire de Médecine du Travail de Paris Ile de France (IIMTPIF), CHI Créteil-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), Epidémiologie et anlyses en santé publique: risques, maladies chroniques et handicaps, Université Paul Sabatier - Toulouse 3 (UPS) - Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Toulouse - Centre hospitalier universitaire de Toulouse - CHU Toulouse, Normandie Université (NU) - Normandie Université (NU) - Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Santé au Travail et Pathologie Professionnelle, CHU Caen, Université de Bordeaux (UB) - Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Université de Bordeaux (UB) - Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED) - Institut National de la Santé et de la Recherche Médicale (INSERM), Centre hospitalier de Nancy (CHU Nancy), Université Bordeaux Segalen - Bordeaux 2 - CHU Bordeaux [Bordeaux] - Institut Bergonié - CRLCC Bordeaux - Institut National de la Santé et de la Recherche Médicale (INSERM) - Cancéropôle du Grand Sud-Ouest, Université Bordeaux Segalen - Bordeaux 2 - Institut Bergonié - CRLCC Bordeaux - Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED), CHU Bordeaux [Bordeaux] - Hôpital Pellegrin, CHI Créteil - Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Service de médecin du travail et de pathologie professionnelle du CHU de Rouen, CHU de Rouen, Equipe de Recherche en Epidémiologie Nutritionnelle (EREN), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS), Institut National de la Recherche Agronomique (INRA) - Université Paris Diderot - Paris 7 (UPD7) - Université Paris Descartes - Paris 5 (UPD5) - Université Paris 13 - Institut National de la Santé et de la Recherche Médicale (INSERM) - Institut National de la Recherche Agronomique (INRA) - Université Paris Diderot - Paris 7 (UPD7) - Université Paris Descartes - Paris 5 (UPD5) - Université Paris 13 - Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Recherche Agronomique (INRA) - Université Paris Diderot - Paris 7 (UPD7) - Université Paris Descartes - Paris 5 (UPD5) - Université Paris 13 - Institut National de la Santé et de la Recherche Médicale (INSERM), and Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12) - Institut National de la Santé et de la Recherche Médicale (INSERM) - IFR10 more...

Subjects
Oncology, Adult, Male, medicine.medical_specialty, Pathology, Colorectal cancer, Health, Toxicology and Mutagenesis, Air Pollutants, Occupational, medicine.disease_cause, Asbestos, 03 medical and health sciences, 0302 clinical medicine, Air pollutants, Internal medicine, Occupational Exposure, medicine, [SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health, Humans, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, Asbestos-related diseases, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, business.industry, Rectal Neoplasms, Incidence (epidemiology), Incidence, Research, Public Health, Environmental and Occupational Health, Middle Aged, medicine.disease, 3. Good health, Occupational Diseases, 030220 oncology & carcinogenesis, [SDV.TOX]Life Sciences [q-bio]/Toxicology, Cohort, Colonic Neoplasms, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, business
Abstract

Background: The relationships between asbestos exposure and colorectal cancer remain controversial. Objectives: We examined the association between asbestos exposure and colorectal cancer incidence. Methods: Volunteer retired workers previously exposed to asbestos were invited to participate in the French ARDCo screening program between 2003 and 2005. Additional data on risk factors for colorectal cancer were collected from the ARDCo-Nut subsample of 3,769 participants in 2011. Cases of colon and rectal cancer were ascertained each year through 2014 based on eligibility for free medical care following a cancer diagnosis. Survival regression based on the Cox model was used to estimate the relative risk of colon and rectal cancer separately, in relation to the time since first exposure (TSFE) and cumulative exposure index (CEI) to asbestos, and with adjustment for smoking in the overall cohort and for smoking, and certain risk factors for these cancers in the ARDCo-Nut subsample. Results: Mean follow-up was 10.2 years among 14,515 men, including 181 colon cancer and 62 rectal cancer cases (41 and 17, respectively, in the ARDCo-Nut subsample). In the overall cohort, after adjusting for smoking, colon cancer was significantly associated with cumulative exposure (HR = 1.14; 95% CI: 1.04, 1.26 for a 1-unit increase in ln-CEI) and ≥ 20–40 years since first exposure (HR = 4.67; 95% CI: 1.92, 11.46 vs. 0–20 years TSFE), and inversely associated with 60 years TSFE (HR = 0.26; 95% CI: 0.10, 0.70). Although rectal cancer was also associated with TSFE 20–40 years (HR = 4.57; 95% CI: 1.14, 18.27), it was not associated with ln-CEI, but these findings must be interpreted cautiously due to the small number of cases. Conclusions: Our findings provide support for an association between occupational exposure to asbestos and colon cancer incidence in men. Citation: Paris C, Thaon I, Hérin F, Clin B, Lacourt A, Luc A, Coureau G, Brochard P, Chamming’s S, Gislard A, Galan P, Hercberg S, Wild P, Pairon JC, Andujar P. 2017. Occupational asbestos exposure and incidence of colon and rectal cancers in French men: the Asbestos-Related Diseases Cohort (ARDCo-Nut). Environ Health Perspect 125:409–415; http://dx.doi.org/10.1289/EHP153 more...

Published
2017
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100. Cancer of the esophagus and asbestos exposure

Author

Mathilde Boulanger, Christophe Paris, Guy Ogier, Bénédicte Clin, Jean-Claude Pairon, Amandine Luc, Isabelle Thaon, Soizick Chamming's, Patrick Brochard, Antoine Gislard, Aude Lacourt, Bodescot, Myriam, Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers (ANTICIPE), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Santé au Travail et Pathologie Professionnellel [CHU Caen], Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Interactions Gènes-Risques environnementaux et Effets sur la Santé (INGRES), Université de Lorraine (UL), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Cancer environnement (EPICENE ), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Bordeaux [Bordeaux], Institut Interuniversitaire de Médecine du Travail de Paris Ile-de-France (IIMTPIF), Service de santé au travail et pathologie professionnelle [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Aliments Bioprocédés Toxicologie Environnements (ABTE), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Service de santé au travail et pathologie professionnelle [Rouen], Agence Régionale de la Santé (ARS), Centre Hospitalier Intercommunal de Créteil (CHIC), Molecular virology and immunology – Physiopathology and therapeutic of chronic viral hepatitis (Team 18) (Inserm U955), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-IFR10-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-IFR10, This work was supported by the French National Health Insurance (Occupational Risk Prevention Department), the French Ministry of Labor and Social Relations, the French Agency for Food, Environmental, and Occupational Health & Safety (ANSES grant 07-CRD-51 and EST 2006/1/43 and EST 2009/68)., CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-UNICANCER, and Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12) more...

Subjects
Male, medicine.medical_specialty, Esophageal Neoplasms, Cumulative Exposure, [SDV.CAN]Life Sciences [q-bio]/Cancer, medicine.disease_cause, Asbestos, 03 medical and health sciences, 0302 clinical medicine, [SDV.CAN] Life Sciences [q-bio]/Cancer, Internal medicine, Humans, Medicine, cancer, 030212 general & internal medicine, Aged, esophagus, business.industry, Proportional hazards model, Incidence (epidemiology), Hazard ratio, Public Health, Environmental and Occupational Health, Cancer, occupational exposure, Middle Aged, medicine.disease, asbestos, mortality, Confidence interval, 3. Good health, Occupational Diseases, [SDV.TOX] Life Sciences [q-bio]/Toxicology, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, 030220 oncology & carcinogenesis, [SDV.TOX]Life Sciences [q-bio]/Toxicology, Cohort, Carcinogens, incidence, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, business, Follow-Up Studies
Abstract

International audience; BACKGROUND:Our study aimed at analyzing incidence and mortality from esophageal cancer within a cohort of workers with previous occupational asbestos exposure (ARDCo Program).METHODS:A 10-year follow-up study was conducted in the 14 515 male subjects included in this program between October 2003 and December 2005. Follow-up began when exposure stopped. Asbestos exposure was analyzed by industrial hygienists using data from a standardized questionnaire. The Cox model was used, with age as the time axis variable adjusted for smoking, time since first exposure (TSFE) and cumulative exposure index (CEI) of exposure to asbestos.RESULTS:We reported a significant dose-response relationship between CEI of exposure to asbestos and esophageal cancer, in both incidence (hazard ratio [HR] 1.26, 95% confidence interval [CI] 1.00-1.58), and mortality (HR 1.40, [95%CI 1.12-1.75]).CONCLUSIONS:This large-scale study suggests the existence of a relationship between asbestos exposure and cancer of the esophagus. more...

Published
2017
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