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Interstitial Lung Abnormalities Detected by CT in Asbestos-Exposed Subjects Are More Likely Associated to Age
- Source :
- Journal of Clinical Medicine, Journal of Clinical Medicine, 2021, 10 (14), pp.3130. ⟨10.3390/jcm10143130⟩, Journal of Clinical Medicine, MDPI, 2021, 10 (14), pp.3130. ⟨10.3390/jcm10143130⟩, Volume 10, Issue 14, Journal of Clinical Medicine, Vol 10, Iss 3130, p 3130 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Objective: the aim of this study was to evaluate the association between interstitial lung abnormalities, asbestos exposure and age in a population of retired workers previously occupationally exposed to asbestos. Methods: previously occupationally exposed former workers to asbestos eligible for a survey conducted between 2003 and 2005 in four regions of France, underwent chest CT examinations and pulmonary function testing. Industrial hygienists evaluated asbestos exposure and calculated for each subject a cumulative exposure index (CEI) to asbestos. Smoking status information was also collected in this second round of screening. Expert radiologists performed blinded independent double reading of chest CT-scans and classified interstitial lung abnormalities into: no abnormality, minor interstitial findings, interstitial findings inconsistent with UIP, possible or definite UIP. In addition, emphysema was assessed visually (none, minor: emphysema &lt<br />25%, moderate: between 25 and 50% and severe: &gt<br />50% of the lung). Logistic regression models adjusted for age and smoking were used to assess the relationship between interstitial lung abnormalities and occupational asbestos exposure. Results: the study population consisted of 2157 male subjects. Interstitial lung abnormalities were present in 365 (16.7%) and emphysema in 444 (20.4%). Significant positive association was found between definite or possible UIP pattern and age (OR adjusted =1.08 (95% CI: 1.02–1.13)). No association was found between interstitial abnormalities and CEI or the level of asbestos exposure. Conclusion: presence of interstitial abnormalities at HRCT was associated to aging but not to cumulative exposure index in this cohort of former workers previously occupationally exposed to asbestos.
- Subjects :
- [SDV.MHEP.AHA] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]
medicine.medical_specialty
asbestosis
Asbestosis
Population
Cumulative Exposure
medicine.disease_cause
[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract
Article
Asbestos
Pulmonary function testing
03 medical and health sciences
0302 clinical medicine
Internal medicine
[SDV.MHEP.AHA]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]
[SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health
Medicine
030212 general & internal medicine
education
[SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health
education.field_of_study
Lung
business.industry
General Medicine
respiratory system
medicine.disease
asbestos-exposition
3. Good health
medicine.anatomical_structure
030228 respiratory system
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
Cohort
HRCT
[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract
Population study
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
business
Subjects
Details
- ISSN :
- 20770383
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Medicine
- Accession number :
- edsair.doi.dedup.....791c9bccda73a6fe390b0c30578e75e3