Search

Your search keyword '"Giovannoni, P."' showing total 1,244 results
Start Over Author "Giovannoni, P."
1,244 results on '"Giovannoni, P."'

51. Evaluation of no evidence of progression or active disease (NEPAD) in patients with primary progressive multiple sclerosis in the ORATORIO trial

Author

Wolinsky, Jerry S, Montalban, Xavier, Hauser, Stephen L, Giovannoni, Gavin, Vermersch, Patrick, Bernasconi, Corrado, Deol‐Bhullar, Gurpreet, Garren, Hideki, Chin, Peter, Belachew, Shibeshih, and Kappos, Ludwig

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Clinical Trials and Supportive Activities, Neurosciences, Brain Disorders, Adolescent, Adult, Antibodies, Monoclonal, Humanized, Disease Progression, Double-Blind Method, Evidence-Based Medicine, Female, Humans, Immunologic Factors, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, Chronic Progressive, Young Adult, Neurology & Neurosurgery, Clinical sciences
Abstract

ObjectiveNo evidence of progression or active disease (NEPAD) is a novel combined endpoint defined by the absence of both progression and inflammatory disease activity in primary progressive multiple sclerosis (PPMS). In the placebo-controlled phase III ORATORIO study (NCT01194570), we investigated the effect of ocrelizumab on this comprehensive outcome and its components in a post-hoc analysis.MethodsThe proportion of patients with NEPAD (no evidence of progression [NEP; no 12-week confirmed progression of ≥1/≥0.5 points on the Expanded Disability Status Scale if the baseline score was ≤5.5/>5.5 points, respectively; no 12-week confirmed progression of ≥20% on the Timed 25-Foot Walk test and 9-Hole Peg Test], no brain magnetic resonance imaging activity [no new/enlarging T2 lesions and no T1 gadolinium-enhancing lesions], and no protocol-defined relapse) from baseline to week 120 was determined in ocrelizumab- (600 mg; n = 465) and placebo-treated (n = 234) patients.ResultsThe majority of ORATORIO study patients with PPMS experienced clinical progression or evidence of disease activity. From baseline to week 120, 29.9% and 42.7% ocrelizumab-treated compared to 9.4% and 29.1% placebo-treated patients maintained NEPAD (relative risk [95% confidence interval {CI}], 3.15 [2.07-4.79]; p

Published
2018

58. Optofluidic Single-Cell Genome Amplification of Sub-micron Bacteria in the Ocean Subsurface.

Author

Landry, Zachary, Vergin, Kevin, Mannenbach, Christopher, Block, Stephen, Yang, Qiao, Blainey, Paul, Carlson, Craig, and Giovannoni, Stephen

Subjects
E01-9C-26, bermuda-atlantic time-series, marine microbiology, microfluidics, optofluidics, single-cell genomics
Abstract

Optofluidic single-cell genome amplification was used to obtain genome sequences from sub-micron cells collected from the euphotic and mesopelagic zones of the northwestern Sargasso Sea. Plankton cells were visually selected and manually sorted with an optical trap, yielding 20 partial genome sequences representing seven bacterial phyla. Two organisms, E01-9C-26 (Gammaproteobacteria), represented by four single cell genomes, and Opi.OSU.00C, an uncharacterized Verrucomicrobia, were the first of their types retrieved by single cell genome sequencing and were studied in detail. Metagenomic data showed that E01-9C-26 is found throughout the dark ocean, while Opi.OSU.00C was observed to bloom transiently in the nutrient-depleted euphotic zone of the late spring and early summer. The E01-9C-26 genomes had an estimated size of 4.76-5.05 Mbps, and contained O and W-type monooxygenase genes related to methane and ammonium monooxygenases that were previously reported from ocean metagenomes. Metabolic reconstruction indicated E01-9C-26 are likely versatile methylotrophs capable of scavenging C1 compounds, methylated compounds, reduced sulfur compounds, and a wide range of amines, including D-amino acids. The genome sequences identified E01-9C-26 as a source of O and W-type monooxygenase genes related to methane and ammonium monooxygenases that were previously reported from ocean metagenomes, but are of unknown function. In contrast, Opi.OSU.00C genomes encode genes for catabolizing carbohydrate compounds normally associated with eukaryotic phytoplankton. This exploration of optofluidics showed that it was effective for retrieving diverse single-cell bacterioplankton genomes and has potential advantages in microbiology applications that require working with small sample volumes or targeting cells by their morphology.

Published
2018

59. No evidence of disease activity (NEDA) analysis by epochs in patients with relapsing multiple sclerosis treated with ocrelizumab vs interferon beta-1a

Author

Havrdová, Eva, Arnold, Douglas L, Bar-Or, Amit, Comi, Giancarlo, Hartung, Hans-Peter, Kappos, Ludwig, Lublin, Fred, Selmaj, Krzysztof, Traboulsee, Anthony, Belachew, Shibeshih, Bennett, Iain, Buffels, Regine, Garren, Hideki, Han, Jian, Julian, Laura, Napieralski, Julie, Hauser, Stephen L, and Giovannoni, Gavin

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Brain Disorders, Multiple Sclerosis, Clinical Trials and Supportive Activities, Clinical Research, Neurodegenerative, Neurosciences, Autoimmune Disease, MRI activity, NEDA, disability progression, disease activity, relapse, Epidemiology, Health services and systems
Abstract

BackgroundNo evidence of disease activity (NEDA; defined as no 12-week confirmed disability progression, no protocol-defined relapses, no new/enlarging T2 lesions and no T1 gadolinium-enhancing lesions) using a fixed-study entry baseline is commonly used as a treatment outcome in multiple sclerosis (MS).ObjectiveThe objective of this paper is to assess the effect of ocrelizumab on NEDA using re-baselining analysis, and the predictive value of NEDA status.MethodsNEDA was assessed in a modified intent-to-treat population (n = 1520) from the pooled OPERA I and OPERA II studies over various epochs in patients with relapsing MS receiving ocrelizumab (600 mg) or interferon beta-1a (IFN β-1a; 44 μg).ResultsNEDA was increased with ocrelizumab vs IFN β-1a over 96 weeks by 75% (p

Published
2018

61. The cool potential of gluons

Author

Peshier, Andre and Giovannoni, Dino

Subjects
High Energy Physics - Phenomenology
Abstract

We put forward the idea that the quark-gluon plasma might exist way below the usual confinement temperature $T_c$. Our argument rests on the possibility that the plasma produced in heavy-ion collisions could reach a transient quasi-equilibrium with `over-occupied' gluon density, as advocated by Blaizot et al. Taking further into account that gluons acquire an effective mass by interaction effects, they can have a positive chemical potential and therefore behave similarly to non-relativistic bosons. Relevant properties of this dense state of interacting gluons, which we dub serried glue, can then be inferred on rather general grounds from Maxwell's relation., Comment: Contribution to the Proceedings of the Conference "Strangeness in Quark Matter", July 6-11, 2015, Dubna, Russia

Published
2015
Full Text
View/download PDF

63. Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes

Author

Sanmarco, Liliana M., Wheeler, Michael A., Gutiérrez-Vázquez, Cristina, Polonio, Carolina Manganeli, Linnerbauer, Mathias, Pinho-Ribeiro, Felipe A., Li, Zhaorong, Giovannoni, Federico, Batterman, Katelyn V., Scalisi, Giulia, Zandee, Stephanie E. J., Heck, Evelyn S., Alsuwailm, Moneera, Rosene, Douglas L., Becher, Burkhard, Chiu, Isaac M., Prat, Alexandre, and Quintana, Francisco J.

Published
2021
Full Text
View/download PDF

69. AHR is a Zika virus host factor and a candidate target for antiviral therapy

Author

Giovannoni, Federico, Bosch, Irene, Polonio, Carolina Manganeli, Torti, María F., Wheeler, Michael A., Li, Zhaorong, Romorini, Leonardo, Rodriguez Varela, María S., Rothhammer, Veit, Barroso, Andreia, Tjon, Emily C., Sanmarco, Liliana M., Takenaka, Maisa C., Modaresi, Seyed Mohamad Sadegh, Gutiérrez-Vázquez, Cristina, Zanluqui, Nágela Ghabdan, dos Santos, Nilton Barreto, Munhoz, Carolina Demarchi, Wang, Zhongyan, Damonte, Elsa B., Sherr, David, Gehrke, Lee, Peron, Jean Pierre Schatzmann, Garcia, Cybele C., and Quintana, Francisco J.

Published
2020
Full Text
View/download PDF

70. Small phytoplankton dominate western North Atlantic biomass

Author

Bolaños, Luis M., Karp-Boss, Lee, Choi, Chang Jae, Worden, Alexandra Z., Graff, Jason R., Haëntjens, Nils, Chase, Alison P., Della Penna, Alice, Gaube, Peter, Morison, Françoise, Menden-Deuer, Susanne, Westberry, Toby K., O’Malley, Robert T., Boss, Emmanuel, Behrenfeld, Michael J., and Giovannoni, Stephen J.

Published
2020
Full Text
View/download PDF

72. Metabolic profile of human parathyroid adenoma

Author

di Masi, Alessandra, Leboffe, Loris, Sodo, Armida, Tabacco, Gaia, Cesareo, Roberto, Sbroscia, Marco, Giovannoni, Isabella, Taffon, Chiara, Crucitti, Pierfilippo, Longo, Filippo, Manfrini, Silvia, Ricci, Maria Antonietta, Ascenzi, Paolo, Crescenzi, Anna, and Palermo, Andrea

Published
2020
Full Text
View/download PDF

75. AHR signaling is induced by infection with coronaviruses

Author

Giovannoni, Federico, Li, Zhaorong, Remes-Lenicov, Federico, Dávola, María E., Elizalde, Mercedes, Paletta, Ana, Ashkar, Ali A., Mossman, Karen L., Dugour, Andrea V., Figueroa, Juan M., Barquero, Andrea A., Ceballos, Ana, Garcia, Cybele C., and Quintana, Francisco J.

Published
2021
Full Text
View/download PDF

77. The giant graviton on AdS_{4} x CP^{3} - another step towards the emergence of geometry

Author

Giovannoni, Dino, Murugan, Jeff, and Prinsloo, Andrea

Subjects
High Energy Physics - Theory
Abstract

We construct the giant graviton on AdS_{4} x CP^{3} out of a four-brane embedded in and moving on the complex projective space. This configuration is dual to the totally anti-symmetric Schur polynomial operator \chi_{R}(A_{1}B_{1}) in the 2+1-dimensional, N = 6 super Chern-Simons ABJM theory. We demonstrate that this BPS solution of the D4-brane action is energetically degenerate with the point graviton solution and initiate a study of its spectrum of small fluctuations. Although the full computation of this spectrum proves to be analytically intractable, by perturbing around a "small'" giant graviton, we find good evidence for a dependence of the spectrum on the size, \alpha_{0}, of the giant. This is a direct result of the changing shape of the worldvolume as it grows in size., Comment: 46 pages, 7 figures. Further details added to section 6 - the solutions to the leading order fluctuation equations and the leading order spectrum have been obtained - and additional comments added to the discussion. Additional references added. Mistake in section 2 corrected

Published
2011
Full Text
View/download PDF

78. The genome of the stress-tolerant wild tomato species Solanum pennellii.

Author

Bolger, Anthony, Scossa, Federico, Bolger, Marie E, Lanz, Christa, Maumus, Florian, Tohge, Takayuki, Quesneville, Hadi, Alseekh, Saleh, Sørensen, Iben, Lichtenstein, Gabriel, Fich, Eric A, Conte, Mariana, Keller, Heike, Schneeberger, Korbinian, Schwacke, Rainer, Ofner, Itai, Vrebalov, Julia, Xu, Yimin, Osorio, Sonia, Aflitos, Saulo Alves, Schijlen, Elio, Jiménez-Goméz, José M, Ryngajllo, Malgorzata, Kimura, Seisuke, Kumar, Ravi, Koenig, Daniel, Headland, Lauren R, Maloof, Julin N, Sinha, Neelima, van Ham, Roeland CHJ, Lankhorst, René Klein, Mao, Linyong, Vogel, Alexander, Arsova, Borjana, Panstruga, Ralph, Fei, Zhangjun, Rose, Jocelyn KC, Zamir, Dani, Carrari, Fernando, Giovannoni, James J, Weigel, Detlef, Usadel, Björn, and Fernie, Alisdair R

Subjects
Chromosomes, Plant, Solanum, DNA Transposable Elements, Chromosome Mapping, Genome, Plant, Quantitative Trait Loci, Stress, Physiological, Chromosomes, Plant, Genome, Stress, Physiological, Developmental Biology, Biological Sciences, Medical and Health Sciences
Abstract

Solanum pennellii is a wild tomato species endemic to Andean regions in South America, where it has evolved to thrive in arid habitats. Because of its extreme stress tolerance and unusual morphology, it is an important donor of germplasm for the cultivated tomato Solanum lycopersicum. Introgression lines (ILs) in which large genomic regions of S. lycopersicum are replaced with the corresponding segments from S. pennellii can show remarkably superior agronomic performance. Here we describe a high-quality genome assembly of the parents of the IL population. By anchoring the S. pennellii genome to the genetic map, we define candidate genes for stress tolerance and provide evidence that transposable elements had a role in the evolution of these traits. Our work paves a path toward further tomato improvement and for deciphering the mechanisms underlying the myriad other agronomic traits that can be improved with S. pennellii germplasm.

Published
2014

79. Single-cell enabled comparative genomics of a deep ocean SAR11 bathytype

Author

Thrash, J Cameron, Temperton, Ben, Swan, Brandon K, Landry, Zachary C, Woyke, Tanja, DeLong, Edward F, Stepanauskas, Ramunas, and Giovannoni, Stephan J

Subjects
Microbiology, Biological Sciences, Ecology, Genetics, Human Genome, Biotechnology, Life Below Water, Alphaproteobacteria, DNA, Intergenic, Ecotype, Genes, rRNA, Genomics, Metagenome, Phylogeny, RNA, Ribosomal, 16S, Seawater, Single-Cell Analysis, Synteny, bathytype, ecotype, metagenomics, SAR11, single-cell genomics, deep ocean, Environmental Sciences, Technology, Biological sciences, Environmental sciences
Abstract

Bacterioplankton of the SAR11 clade are the most abundant microorganisms in marine systems, usually representing 25% or more of the total bacterial cells in seawater worldwide. SAR11 is divided into subclades with distinct spatiotemporal distributions (ecotypes), some of which appear to be specific to deep water. Here we examine the genomic basis for deep ocean distribution of one SAR11 bathytype (depth-specific ecotype), subclade Ic. Four single-cell Ic genomes, with estimated completeness of 55%-86%, were isolated from 770 m at station ALOHA and compared with eight SAR11 surface genomes and metagenomic datasets. Subclade Ic genomes dominated metagenomic fragment recruitment below the euphotic zone. They had similar COG distributions, high local synteny and shared a large number (69%) of orthologous clusters with SAR11 surface genomes, yet were distinct at the 16S rRNA gene and amino-acid level, and formed a separate, monophyletic group in phylogenetic trees. Subclade Ic genomes were enriched in genes associated with membrane/cell wall/envelope biosynthesis and showed evidence of unique phage defenses. The majority of subclade Ic-specfic genes were hypothetical, and some were highly abundant in deep ocean metagenomic data, potentially masking mechanisms for niche differentiation. However, the evidence suggests these organisms have a similar metabolism to their surface counterparts, and that subclade Ic adaptations to the deep ocean do not involve large variations in gene content, but rather more subtle differences previously observed deep ocean genomic data, like preferential amino-acid substitutions, larger coding regions among SAR11 clade orthologs, larger intergenic regions and larger estimated average genome size.

Published
2014

80. LMNA::NTRK1 and PRDX1::NTRK1 Atypical Spitz Tumor: A Report of Two Additional Cases With Histological, Immunohistochemical, and Molecular Insights

Author

Cazzato, Gerardo, Colagrande, Anna, Resta, Leonardo, Trilli, Irma, Lupo, Carmelo, Ingravallo, Giuseppe, Caporusso, Concetta, Giovannoni, Isabella, and Barresi, Sabina

Abstract

Over the past decade, advancements in molecular biology have contributed to changes in the diagnostic classification of Spitz neoplasms, including Spitz nevi, atypical Spitz tumors, and Spitz melanomas. The recent World Health Organization classification of skin tumors identifies fusion kinases, including NTRK1, NTRK2, and NTRK3, as critical drivers of these lesions. New fusion genes have continued to expand the spectrum of known molecular alterations, particularly within the category of Spitz NTRK-rearranged lesions. We present 2 new cases of NTRK-rearranged Spitz lesions: an atypical Spitz tumor with common LMNA::NTRK1 fusion and an atypical Spitz tumor with a rare PRDX1::NTRK1 fusion. Clinical, histopathological, immunohistochemical, and molecular analyses were performed to diagnose these patients. This report adds to the growing body of knowledge on NTRK-rearranged Spitz lesions and underscores the importance of integrating molecular findings with morphological and immunohistochemical data for the accurate classification and understanding of these neoplasms.

Published
2025
Full Text
View/download PDF

81. Joint Healthcare Professional and Patient Development of Communication Tools to Improve the Standard of MS Care

Author

Oreja-Guevara, Celia, Potra, Stanca, Bauer, Birgit, Centonze, Diego, Giambastiani, Maria-Paz, Giovannoni, Gavin, Kesselring, Jürg, Langdon, Dawn, Morrow, Sarah A., Nouvet-Gire, Jocelyne, Pontaga, Maija, Rieckmann, Peter, Schippling, Sven, Alexandri, Nektaria, Shanahan, Jane, Thompson, Heidi, Van Galen, Pieter, Vermersch, Patrick, and Yeandle, David

Published
2019
Full Text
View/download PDF

83. The tomato pan-genome uncovers new genes and a rare allele regulating fruit flavor

Author

Gao, Lei, Gonda, Itay, Sun, Honghe, Ma, Qiyue, Bao, Kan, Tieman, Denise M., Burzynski-Chang, Elizabeth A., Fish, Tara L., Stromberg, Kaitlin A., Sacks, Gavin L., Thannhauser, Theodore W., Foolad, Majid R., Diez, Maria Jose, Blanca, Jose, Canizares, Joaquin, Xu, Yimin, van der Knaap, Esther, Huang, Sanwen, Klee, Harry J., Giovannoni, James J., and Fei, Zhangjun

Published
2019
Full Text
View/download PDF

84. Can Public Radio Replace Federal Funds with Audience-Sensitive Income? Info. Packets No. 16.

Author

Giovannoni, David

Abstract

Public radio can survive cutbacks in federal subsidies, but only if these funds are reduced no more rapidly than public radio can replace them with newly-generated audience-sensitive revenues (listener support and underwriting). A model developed in this analysis suggests a three-to-five year "glide path" to zero federal support. Public radio has been moving away from a subsidized economy toward a user-based economy for 15 years. Direct reliance on listeners and underwriting has caused certain changes in the very nature of the medium. Cutbacks in federal subsidies will accelerate changes already well underway. Certain vestigial privileges and mandates inherent in a subsidized economy are being displaced by the responsibilities and imperatives of a user-based economy. Meeting these responsibilities requires that public radio preserve the assets and enhance the endeavors that make it the valued public service that it is. Now more than ever it must serve significant audiences with significant programming--programming that is worth listening to and worth supporting. (Contains 8 graphs.) (Author)

Published
1995

92. Thyroid cancer diagnosis by Raman spectroscopy

Author

Sbroscia, Marco, Di Gioacchino, Michael, Ascenzi, Paolo, Crucitti, Pierfilippo, di Masi, Alessandra, Giovannoni, Isabella, Longo, Filippo, Mariotti, Davide, Naciu, Anda Mihaela, Palermo, Andrea, Taffon, Chiara, Verri, Martina, Sodo, Armida, Crescenzi, Anna, and Ricci, Maria Antonietta

Published
2020
Full Text
View/download PDF

97. mRNA Display Identifies Potent, Paralog-Selective Peptidic Ligands for ARID1B.

Author

Cremosnik, Gregor S., Mesrouze, Yannick, Zueger, Patrik, Furkert, David, Grandjean, Frédéric, Argoti, Dayana, Mermet-Meillon, Fanny, Bauer, Matthias R., Brittain, Scott, Rogemoser, Phuong, Yang, Winnie, Giovannoni, Jerome, McGregor, Lynn, Tang, Jenny, Knapp, Mark, Holzinger, Sandra, Buhr, Sylvia, Muller, Lionel, Leder, Lukas, and Xie, Lili

Published
2024
Full Text
View/download PDF

98. Complementing Braden scale for pressure ulcer risk with clinical and demographic-related factors in a large cohort of hospitalized Italian patients.

Author

Giovannoni, Lorenzo, Longobucco, Yari, Iovino, Paolo, Barbetti, Chiara, Becattini, Silvia, Bonanni, Daniela, Cordelli, Francesco, Cosci, Matteo, Del Perugia, Cristiana, Flego, Rachele, Giannuzzi, Domenica, Guasti, Barbara, Iannone, Sabrina Roberta, Latini, Riccardo, Macchitella, Consuelo, Piccardi, Francesca, Prisco, Elia, Pucci, Tiziana, Tricca, Manola, and Rasero, Laura

Abstract

To determine the prevalence, risk, and determinants of pressure ulcer risk in a large cohort of hospitalized patients. A prospective cross-sectional study with data collection in January 2023. Registered nurses collected data from 798 patients admitted to 27 health care units of an Italian hospital. The pressure ulcer risk was assessed using the Braden scale. The presence of comorbidities was collected from clinical reports. Obesity was assessed according to international indicators (Body Mass Index). The receiver operating characteristic (ROC) curve was used to estimate the sensitivity and specificity of different Braden scores for identifying participants with pressure ulcers. The prevalence of pressure ulcers was 9.5%, and 57.4% of the sample were at risk of developing pressure ulcers. The area under the ROC curve was 0.88. The best sensitivity and specificity were found for a Braden cutoff score of 15.5 (sensibility = 0.76; specificity = 0.85). The determinants of lower Braden scores were older age (p < 0.001), comorbidities (p < 0.001), wounds of other nature (p = 0.001), urinary incontinence (p < 0.001), fecal incontinence (p < 0.001), and urinary catheterization (p < 0.001). Several demographic factors and specific clinical indicators have been identified as determinants of the risk of developing pressure ulcers, which are easily ascertainable by healthcare providers; thus, they may routinely complement the Braden Scale in the assessment of pressure ulcer risk in order to reinforce and accelerate clinical judgment. • Other forms of clinical judgment should integrate pressure ulcer risk assessments. • Several easy-to-collect factors have been identified as pressure ulcer risk factors. • Braden scale exhibits satisfactory concurrent validity in an Italian sample. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results