51. Cross-reactivity between an HLA-B27-derived peptide and a retinal autoantigen peptide: a clue to major histocompatibility complex association with autoimmune disease
- Author
-
Gerhild Wildner and Stephan R. Thurau
- Subjects
Molecular Sequence Data ,Immunology ,Human leukocyte antigen ,Cross Reactions ,Biology ,medicine.disease_cause ,Major histocompatibility complex ,Autoantigens ,Cross-reactivity ,Epitope ,Autoimmune Diseases ,Uveitis ,Antigen ,Immune Tolerance ,medicine ,Animals ,Humans ,Immunology and Allergy ,Amino Acid Sequence ,Lymphocytes ,Antigens ,Eye Proteins ,HLA-B27 Antigen ,Autoimmune disease ,HLA-B27 ,Arrestin ,Sequence Homology, Amino Acid ,medicine.disease ,Rats ,Rats, Inbred Lew ,biology.protein ,Immunization - Abstract
Statistical correlations between the expression of various HLA antigens and certain autoimmune diseases have been observed for both HLA class I and II antigens. Autoimmune diseases like spondyloarthropathies and anterior uveitis are associated with HLA-B27, but uveitis in Behçet's disease with HLA-B51. We describe a peptide from disease-associated HLA class I antigens sharing sequence homologies with a highly uveitogenic epitope from the retinal autoantigen S-antigen. S-antigen induces autoimmune uveitis in the animal model and is a major autoantigen in human disease. The HLA peptide induced uveitis in the Lewis rat and, moreover, suppressed S-antigen-induced disease when administered orally. Patients' PBL cross-reacted with the HLA- and corresponding retinal peptide, explaining the organ specificity of the disease.
- Published
- 1994