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Uveitis in horses induced by interphotoreceptor retinoid-binding protein is similar to the spontaneous disease
- Source :
- European journal of immunology. 32(9)
- Publication Year :
- 2002
-
Abstract
- Equine recurrent uveitis (ERU) is an inflammatory eye disease with high similarity to uveitis in man. It is the only spontaneous animal model for uveitis and the most frequent eye disease in horses affecting up to 10% of the population. To further investigate the pathophysiology of ERU we now report the establishment of an inducible uveitis model in horses. An ERU-like disease was elicited in seven out of seven horses by injection of interphotoreceptor retinoid-binding protein (IRBP) in complete Freund's adjuvant. Control horses did not develop uveitis. The disease model is characterized by a highly reproducible disease course and recurrent episodes with an identical time course elicited in all horses by repeated IRBP injections. The histology revealed the formation of lymphoid follicle-like structures in the eyes and an intraocular infiltration dominated by CD3(+) lymphocytes, morphological patterns typical for the spontaneous disease. Antigen-specific T cell proliferation of PBL was monitored prior to clinical uveitis and during disease episodes. An initial T cell response to IRBP-derived peptides was followed by epitope spreading to S-antigen-derived peptides in response to subsequent immunizations. Thus, horse experimental uveitis represents a valuable disease model for comparative studies with the spontaneous disease and the investigation of immunomodulatory therapeutic approaches after onset of the disease.
- Subjects :
- CD3 Complex
Freund's Adjuvant
Molecular Sequence Data
Immunization, Secondary
Reproducibility of Results
Lymphocyte Activation
Autoantigens
Peptide Fragments
Autoimmune Diseases
Retinol-Binding Proteins
Uveitis
Disease Models, Animal
Pertussis Toxin
Species Specificity
Recurrence
T-Lymphocyte Subsets
Leukocytes, Mononuclear
Animals
Humans
Cattle
Horse Diseases
Immunization
Amino Acid Sequence
Horses
Eye Proteins
Subjects
Details
- ISSN :
- 00142980
- Volume :
- 32
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- European journal of immunology
- Accession number :
- edsair.pmid..........c4bc23faa84b81accf363ffbaf265c2e