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Researchers from Fujian Medical University in Fuzhou, China, have developed a novel biomimetic nanozyme called NM@Fe-DMY to target neuroinflammatory regions in early brain injury following subarachnoid hemorrhage (SAH). This nanozyme shows promising catalytic activities and the ability to penetrate the blood-brain barrier, leading to reduced oxidative stress, improved neural function, and modulation of neuroinflammation. The study introduces a new strategy for enhancing the treatment of SAH-induced early brain injury. [Extracted from the article]

A study conducted by Fujian Medical University in China investigated the prevalence of hepatitis B virus (HBV) among pregnant women and their neonates in Yinchuan. The study found that the prevalence of HBV among pregnant women was 2.5%, with a declining trend every year. Risk factors associated with cord blood HBsAg positivity included delivery by cesarean section, maternal HBeAg positivity, and maternal viral load. The study emphasizes the importance of public education and postnatal follow-up to prevent mother-to-child transmission of HBV. [Extracted from the article]

Researchers from Fuzhou University in China have developed polyhexamethylene biguanide-bismuth tungstate-poly(vinylpyrrolidone) nanoparticles (PHMB-BWO-PVP NPs) for the treatment of drug-resistant bacterial infections. These nanoparticles combine chemical and low-temperature photothermal therapy (CT/LT-PTT) to effectively combat multidrug-resistant infections. The NPs were found to have excellent bactericidal effects against drug-resistant bacteria and inhibited the formation of bacterial biofilms. In addition, the NPs promoted wound tissue healing by inducing the transformation of macrophages and facilitating collagen deposition and angiogenesis. This research provides new insights into the use of nanoparticles for the treatment of drug-resistant bacterial infections. [Extracted from the article]

A report from Fujian Agriculture and Forestry University in Fuzhou, China discusses the prospects of phycoerythrin (PE), a plant protein of algal origin. The research highlights the importance of the structure of PE in relation to its antioxidant activity and stability. Factors such as light, high temperature, and extreme pH can affect the thermal stability of PE, but techniques such as the incorporation of additives and cross-linking processes can enhance its stability. The paper also explores the application of PE in the food industry and strategies for improving its stability. [Extracted from the article]

A systematic review and meta-analysis conducted by Shaokai He and colleagues from Fuzhou, People's Republic of China, examined the impact of different types, durations, and intensities of physical exercise on depressive symptoms in older adults aged 60 years and above. The researchers retrieved randomized controlled trials from various databases and found that engaging in physical exercise led to a significant improvement in depressive symptoms among older individuals. Moderate and high-intensity physical exercise, resistance exercise, and group exercise were found to be more effective in improving depressive symptoms. Additionally, exercise interventions lasting 3 or 6 months were associated with better outcomes. The study emphasizes the importance of appropriate exercise intervention time for sustainable improvement. [Extracted from the article]

A recent study conducted by investigators from Fujian Normal University in Fuzhou, People's Republic of China, explores the use of fast multiphoton microscopic imaging and deep learning for automated Gleason grading of prostate cancers. The researchers utilized a deep learning architecture for image super-resolution to improve the quality of low-resolution images and increase the acquisition speed. They also introduced a classification network for automated Gleason grading, achieving high classification accuracy. The results suggest that this method has the potential to be a real-time clinical diagnostic tool for prostate cancer diagnosis. The research has been peer-reviewed and published in the Journal of Biophotonics. [Extracted from the article]

A study conducted at Fujian Medical University in Fuzhou, China, has explored the use of self-assembled peptide hydrogels loaded with a functional peptide called Dentonin for bone tissue regeneration. The hydrogels were found to promote the adhesion, proliferation, and migration of bone marrow mesenchymal stem cells (BMSCs), as well as induce differentiation towards osteogenesis. Additionally, the hydrogels increased the migration, tube formation, and angiogenic gene expression of human umbilical vein endothelial cells (HUVECs), enhancing their angiogenic capacity. In vivo experiments on rats showed that the hydrogels significantly improved vascularized bone formation. This research suggests that the functionalized self-assembling peptide hydrogel could be a promising material for oral and maxillofacial regeneration. [Extracted from the article]

A recent study conducted at Fujian Agricultural and Forestry University in Fuzhou, China, has explored the use of a new type of wound dressing for improved wound healing. The researchers developed a 3D biomimetic nanofiber scaffold composed of hydrophobic and hydrophilic materials, along with antibacterial nano-chitin particles. In vitro and in vivo experiments demonstrated that this scaffold exhibited excellent antibacterial properties and compatibility with cells, promoting complete wound healing and regeneration. The study suggests that this innovative approach could potentially be used as an alternative strategy for clinical applications. [Extracted from the article]

Researchers from Fuzhou University in China have made new findings in the field of photoelectrochemicals. They have developed a photoelectrochemical immunoassay platform that utilizes the catalytic activity of indium oxysulfide to generate hydroxyl radicals and quench the photocurrent signal. This platform was successfully used for the detection of carcinoembryonic antigen, with a remarkable limit of detection of 8.9 pg mL(-1). The study provides insights into the mechanisms of electron-hole transport in semiconductor materials and could lead to the development of more efficient photoelectrochemical sensors. [Extracted from the article]

A recent report from Fuzhou University in China discusses the use of nanozymes for the detection of hydrogen peroxide (H2O2) in cells. The researchers successfully prepared a Pt-Cd bimetallic nanozyme that exhibited good electrochemical activity and sensitivity to H2O2. The nanozyme was used to detect H2O2 in human hepatocellular carcinoma cells, potentially enabling early detection of cellular carcinogenesis. This research offers a simple, rapid, and inexpensive method for electrochemical sensing and provides a new pathway for the synthesis of bimetallic nanozymes. [Extracted from the article]

Researchers from the Fujian Academy of Agricultural Sciences in Fuzhou, China have found that fumigation with dimethyl trisulfide (DMTS) can effectively control bacterial canker of tomatoes. DMTS inhibits the growth of Clavibacter michiganensis subsp. michiganensis (Cmm), the bacteria that causes the disease, and alters its morphology and membrane structure. The fumigation also reduces biofilm formation and exopolysaccharide secretion by Cmm. Additionally, DMTS treatment improves fruit quality by reducing weight loss, disease incidence, and the disease index in tomatoes, while increasing the level of ascorbic acid and inhibiting ethylene synthesis. This research provides insights into the potential use of DMTS fumigation in tomato production to enhance fruit quality and reduce postharvest bacterial canker. [Extracted from the article]

A recent study conducted at Fujian Agricultural and Forestry University in Fuzhou, China, explored the effects of a specific oligosaccharide called Lacto-n-fucopentaose I (LNFPI) on Enterovirus 71 (EV71) infection. EV71 is a major cause of hand, foot, and mouth disease in children. The researchers found that LNFPI reduced energy hijacking by the virus and alleviated metabolic abnormalities caused by the infection. Additionally, LNFPI hindered the replication of EV71 by affecting nucleotide transcription and metabolism. This research provides insights into potential therapeutic interventions for EV71 infection. [Extracted from the article]

A report from Fuzhou University in China discusses the biosynthesis of a nonnutritive monosaccharide called d-allulose using Escherichia coli bacteria. The researchers aimed to develop a cell factory for d-allulose production as an alternative to sucrose, which is associated with metabolic disorders. They successfully engineered E. coli to produce d-allulose from sucrose, achieving an increase in titer and yield. The study concludes that the titer of d-allulose reached 11.15 g/L, with a yield of 0.208 g/g on sucrose. This research provides new insights into the production of nonnutritive sweeteners. [Extracted from the article]

Researchers at Fujian Agricultural and Forestry University in Fuzhou, China have developed a new type of nanofibrous film for food packaging. The film is made from konjac glucomannan-gelatin (KGM-GEL) and polycaprolactone (PCL) nanofibers, which improve the film's hydrophobicity and mechanical properties. The researchers found that the bilayer nanofibrous films composed of PCL and KGM-GEL displayed a homogenous morphology and preserved the physicochemical properties of each biopolymer. The addition of PCL nanofibers significantly improved the hydrophobicity of the KGM-GEL-based nanofibers. The researchers concluded that this new material shows promise for food packaging applications. [Extracted from the article]

Researchers at Fuzhou University in China have published a report on the dual inhibitory effects of zinc-binding peptides on Staphylococcus aureus (S. aureus) bacteria. The study found that these peptides disrupted the cytomembrane of the bacteria, causing metabolic disorder and decreased biofilm viability. When tested on pork models, the peptides were able to reduce S. aureus colonization and enterotoxin secretion. This research provides a potential strategy for mitigating the risk of S. aureus contamination in pork. [Extracted from the article]

A report from Fujian Normal University in Fuzhou, People's Republic of China, explores the relationship between moderate-to-vigorous physical activity (MVPA) and cognitive performance. Using a Mendelian randomization approach, the researchers analyzed two samples and found that increased MVPA was associated with a decrease in cognitive risk, while enhanced cognitive levels corresponded to a reduced risk of inadequate MVPA. These findings provide valuable insights for developing personalized prevention and intervention strategies in health and sports sciences. The full study can be accessed in the journal Frontiers in Psychology. [Extracted from the article]

A study conducted by Fujian Medical University in Fuzhou, China, examined the efficacy of different treatment strategies using pegylated interferon (PEG-IFN) for achieving sustained clearance of hepatitis B surface antigen (HBsAg) in patients with chronic hepatitis B (CHB). The study analyzed 53 studies involving 9,338 CHB patients and found that the annual rates of HBsAg clearance and seroconversion after PEG-IFN withdrawal were 6.9% and 4.7%, respectively. The study also identified factors such as HBsAg quantification, hepatitis B e antigen status, and PEG-IFN treatment protocols as sources of heterogeneity. The researchers concluded that combining PEG-IFN with tenofovir may be the most effective approach for achieving sustained HBsAg seroconversion. [Extracted from the article]

A study conducted by researchers at Fujian Medical University in Fuzhou, China, has developed a portable sensor for the detection of exosomes, which are considered promising biomarkers for cancer diagnosis. The sensor, made of a three-layer Au mirror/SiO2 spacer/Au nanohole, demonstrated high sensitivity and reproducibility in detecting exosomes. By modifying the sensor with specific aptamers, it was able to distinguish between non-tumor and tumor-derived exosomes. This research provides an effective approach to improving the detection sensitivity of exosomes, advancing the field of cancer diagnosis. [Extracted from the article]

A recent study conducted by Fujian Medical University in Fuzhou, China, explored the effects of a nurse-led art-based cognitive intervention on older adults with Alzheimer's disease. The study found that participants who underwent the intervention experienced improved cognition and psychological health. The intervention program consisted of a 16-week, 24-session art-based cognitive training program. The findings suggest that art activities may enhance neural network function and potentially prevent or reverse cognitive decline. This research provides valuable insights into the potential benefits of art-based interventions for individuals on the Alzheimer's disease spectrum. [Extracted from the article]

A recent study conducted by the Chinese Academy of Sciences in Fuzhou, China, has developed a 3D-printed bone repair scaffold that enhances bone regeneration. The scaffold, made from a composite material called Hydroxyapatite+ kappa-Carrageenan/Polyvinyl alcohol (HA+ kappa-CA/PVA), incorporates a drug called icariin (ICA) to promote anti-inflammation and bone repair. The scaffold demonstrated excellent printability, hydrophilicity, and mechanical properties, and in vitro experiments showed that it stimulated the differentiation of osteoblasts and regulated the polarization of macrophages. The researchers concluded that the scaffold holds great potential for bone tissue regeneration. [Extracted from the article]

A study conducted by researchers at Fujian Normal University in Fuzhou, China, has investigated the role of collagen in breast cancer development. The researchers used multiphoton microscopy to examine the morphological changes in collagen fibers in different regions of breast cancer tumors. They found significant differences in collagen morphology between the tumor boundary, the transition region near the tumor, and normal tissues far from the tumor. These findings could potentially contribute to a better understanding of tumor metastasis and inform breast-conserving surgery. The study was funded by various scientific foundations in China. [Extracted from the article]

A study conducted by researchers at Fujian Medical University in Fuzhou, China, aimed to establish a prognostic gene model for pediatric neuroblastoma (NB) patients. The study found that ferroptosis-related genes are correlated with the prognosis of NB patients. The researchers identified 70 ferroptosis-related genes and narrowed it down to five prognostic genes (STEAP3, MAPDLC3A, ULK2, MTOR, and TUBED) to construct a prognostic signature. The study also found that immune infiltration may play a role in different risk groups for NB patients. This research has been peer-reviewed and published in Translational Cancer Research. [Extracted from the article]

A recent study conducted by researchers at Fujian Medical University in Fuzhou, China, has investigated the role of glucose-6-phosphate dehydrogenase (G6PD) in temporomandibular joint osteoarthritis (TMJOA). The study found that G6PD knockdown in mandibular condylar chondrocytes (MCCs) reduced the expression of catabolic enzymes and inflammatory cytokines induced by IL-1 beta. Additionally, G6PD knockdown mitigated IL-1 beta-induced upregulation of ERK, JNK, and p38 phosphorylation and reduced reactive oxygen species (ROS) levels. The researchers concluded that G6PD may regulate the inflammatory state of condylar chondrocytes via the NOXROS-MAPK axis, suggesting its potential as a therapeutic target for TMJOA. [Extracted from the article]

A study conducted by researchers at Fujian Medical University in Fuzhou, China, has found that paclitaxel (PTX), a chemotherapy drug, can worsen radiation-induced pulmonary fibrosis (RIPF) in patients with thoracic tumors. The study suggests that PTX inhibits the negative regulatory function of Spry2, a protein involved in the regulation of cell signaling pathways, leading to the upregulation of the Raf/extracellular signal regulated kinase (ERK) signaling pathway. The findings provide potential drug targets for mitigating the complications of PTX treatment in patients with thoracic tumors. The study was published in the Journal of Pharmacology and Experimental Therapeutics. [Extracted from the article]

Researchers from Fuzhou University in China have published a study on drug-drug interactions (DDIs) in the field of obesity, fitness, and wellness. The study introduces a deep learning framework called MeTDDI, which utilizes local-global self-attention and co-attention to predict DDIs. The framework achieved competitive performance and demonstrated the ability to explain the structural mechanisms of DDIs. The researchers believe that MeTDDI can provide valuable insights for drug discovery and polypharmacy, leading to safer therapies for patients. The study suggests that this method could help optimize drug combinations and reduce the risks of adverse drug interactions. [Extracted from the article]

A case report from Fujian Medical University in Fuzhou, People's Republic of China, discusses the use of hydrogel combined with alginate dressings in the treatment of grade 4 acute radiation dermatitis. The combination of hydrogel and alginate dressings facilitated wound closure by promoting autolytic debridement and creating a moist healing environment. The treatment resulted in a gradual decrease in wound size and exudate, with complete healing achieved in 20 days and 17 dressing changes. The study supports the clinical application and promotion of this approach for wound management in acute radiation dermatitis. [Extracted from the article]

A recent study conducted by researchers at Fuzhou University in China has found that brain-targeting dihydromyricetin-decorated selenium nanoparticles (Tg-CS/DMY@SeNPs) show promise in the treatment of Alzheimer's disease (AD) by attenuating oxidative stress. The researchers discovered that Tg-CS/DMY@SeNPs improved the solubility of dihydromyricetin and exhibited better free radical scavenging ability. Additionally, these nanoparticles enhanced the activity of antioxidant enzymes and activated the Nrf2/Keap-1 signaling pathway, which regulates the activity of antioxidant enzymes. The study concluded that Tg-CS/DMY@SeNPs have potential therapeutic effects in the antioxidant therapy of AD. [Extracted from the article]

A recent study conducted in Fuzhou, People's Republic of China, explored the role of a specific gene called USP19 in reducing ferroptosis and mitochondrial damage in Alzheimer's disease (AD) cells. The researchers found that knockdown of USP19 decreased the expression of NOX4 protein, promoted the expression of mitochondrial fusion proteins, and inhibited the expression of splitting protein Drp1. Additionally, USP19 knockdown decreased mitochondrial membrane potential and intracellular iron content, while increasing the GSH/GSSG ratio in AD cells. The study concluded that USP19 attenuates mitochondrial damage in AD cells by targeting NOX4 protein. This research provides new insights into the understanding of neurodegenerative diseases like Alzheimer's. [Extracted from the article]

A study conducted in southeastern China investigated the clinical and genetic characteristics of ten children with ornithine carbamoyltransferase deficiency (OTCD). The study found that the clinical manifestations of OTCD lack specificity, but elevated blood ammonia levels can serve as a diagnostic clue. Genetic testing was found to aid in more accurate diagnosis and prognosis assessment. The study also identified two novel pathogenic variants of the OTC gene, expanding the understanding of the genetic characteristics of OTCD patients. [Extracted from the article]

A recent study conducted by researchers at Fujian Agriculture and Forestry University in Fuzhou, People's Republic of China, aimed to understand the unique flavor of Tieguanyin oolong tea, known as "Yin Rhyme." Through sensory evaluations, electronic tongue analysis, and metabolomics, the researchers found that Tieguanyin tea exhibits a thick and mellow taste profile, with higher concentrations of umami and bitter substances compared to another variety of oolong tea. The study also revealed that the cultivar of the tea plays a crucial role in developing the "Yin Rhyme" flavor, which is enhanced during the tea processing stages. This research provides a theoretical foundation for understanding the formation of the unique flavor of Tieguanyin oolong tea. [Extracted from the article]

Researchers from Fujian Medical University in Fuzhou, China have developed a new approach to enhance the effectiveness of radiotherapy (RT) in the treatment of nasopharyngeal carcinoma (NPC). They have created a nanocarrier coated with indocyanine green (ICG) and red blood cell membrane (RBCM) that improves tumor localization and systemic circulation. The nanocarrier, called Gd-metal-organic framework (MOF), accumulates at the tumor site and enhances the tumor uptake potential, making it more sensitive to RT. This innovative theranostic nanoplatform combines material science with biomedical engineering and shows promise for targeted cancer treatments. [Extracted from the article]

A recent study conducted by Fujian Medical University in Fuzhou, China, aimed to differentiate between definite Meniere's disease (DMD) and probable Meniere's disease (PMD) using audio-vestibular function testing and inner ear gadolinium magnetic resonance imaging (MRI). The study enrolled 116 patients diagnosed with DMD and PMD and compared the results of various tests between the two groups. The researchers identified parameters that could differentiate between the two conditions and found that a comprehensive assessment of audio-vestibular function testing and inner ear MRI can contribute to early diagnosis and the preservation of inner ear function. [Extracted from the article]

A recent study conducted at Fuzhou University in China has developed a biosensor that can quantitatively monitor the levels of microRNA-21 (miR-21) in vivo during cancer initiation and progression. MiR-21 is known to be upregulated in tumors and is closely associated with tumor occurrence. Traditional imaging methods for miR-21 are limited to qualitative imaging, but this new biosensor, called DCNP@DNA2@IR806, utilizes a ratiometric fluorescent nanoprobe to provide real-time monitoring of miR-21 levels. This research has the potential to enhance our understanding of microRNA-based molecular mechanisms in cancer and lay the foundation for early diagnosis of microRNA-related diseases. [Extracted from the article]

A study conducted at Fujian Medical University in Fuzhou, China, explored the use of orthodontic rubber bands combined with clips to assist in the endoscopic resection of gastric submucosal tumors (SMTs). The study found that using orthodontic rubber bands shortened the surgical time compared to conventional methods. The researchers concluded that further large prospective studies are needed to confirm these findings. This research provides valuable insights into improving the safety and effectiveness of minimally invasive methods for treating gastric SMTs. [Extracted from the article]

Researchers from Fuzhou University in China have developed a time-varying equivalent circuit model for intracardiac communication in leadless pacemakers. The study addresses the challenges posed by the time-varying characteristics of the intracardiac channel. The researchers used an electrical properties-based approach to establish a quasi-static and continuous time-varying equivalent circuit model, which was validated through ex vivo experiments. The proposed model provides a reliable and effective tool for addressing time-varying challenges in pacemaker development. [Extracted from the article]

A study conducted by researchers at Fuzhou University in China explores the challenges of reshaping global supply chains for bulk mining commodities in the wake of the COVID-19 pandemic. The study introduces a bi-level programming model for decentralized mining supply chain network design, which captures interactions between upper-level ore production and lower-level ore processing enterprises. The researchers developed a hybrid math-heuristic algorithm called SCDEA-CRM to solve the computational complexity of the model. The study concludes with a sensitivity analysis on the impact of product iron content variations on supply chain costs. This research has been peer-reviewed and provides valuable insights into decentralized mining supply chain network design. [Extracted from the article]

A report from Minjiang University in Fuzhou, China explores the impact of health information echo chambers on the avoidance behavior of older adults. The study suggests that the prevalence of algorithm-driven content push in the digital media era has led to excessive homogenization and overload of information, limiting older adults' access to diverse health information and potentially inducing avoidance behaviors. The study identifies health information similarity and overload as factors that increase information fatigue and promote avoidance behavior, while trait mindfulness serves as a moderating factor. The research emphasizes the importance of breaking the health information echo chamber and promoting diverse information dissemination to improve the health information behavior of older adults. [Extracted from the article]

A recent study conducted by Fuzhou University in China explored the potential relationship between female genital prolapse (FGP) and psychiatric disorders. Using a two-sample Mendelian randomization analysis, the researchers found that FGP may have a marginal protective effect on bipolar disorder and schizophrenia. However, there was no causal correlation between FGP and obsessive-compulsive disorder, depression, anxiety disorders, or post-traumatic stress disorder. The study suggests a potential causal relationship between FGP and bipolar disorder or schizophrenia but does not find any association with other psychiatric disorders. [Extracted from the article]

A recent report from Fuzhou University in China discusses the development of a bio-inspired self-healing hydrogel for the treatment of gastric ulcers. The hydrogel, which incorporates a targeted agent called TCP-25 peptide, demonstrates rapid hemostasis and superior wound healing in gastric ulcers. In experiments with rats, the hydrogel effectively inhibited gastric ulcer bleeding by 92% within 24 hours, outperforming the commonly used clinical treatment omeprazole. This research offers promising clinical applications for the treatment of gastric ulcers. [Extracted from the article]

The article discusses new findings from Fujian Medical University on Ginsenoside Rg1's potential in treating myocardial ischemia. The research integrates virtual screening and proteomics to identify targets like MAPK1 and ADK, revealing that Rg1 alleviates oxidative stress and inhibits the oxidative phosphorylation pathway in cardiomyocytes. Topics include the mechanisms of Rg1's protective effects, key protein targets, and methodological approaches for studying natural active ingredients.

A study conducted at Fuzhou University in China has developed a dual-mode upconversion nanoparticle (UCNP) biosensor for the detection of heparin, protamine, and trypsin. Heparin is a negatively charged sulfated linear polymer glycosaminoglycan used as an anticoagulant, while protamine is a cationic protein used to treat excess heparin during surgery. Trypsin is an important digestive enzyme. The biosensor demonstrated sensitive detection with low limits of detection for each target. The research concluded that the biosensor could eliminate autofluorescence and provide a new sensing pathway for detecting differently charged biotargets. [Extracted from the article]

Researchers at Fujian Medical University in Fuzhou, China have conducted a computational study on the interaction between metal organic frameworks (MOFs) and the drug 5-fluorouracil (5-Fu). By substituting transition metal atoms for copper in the MOF HKUST-1, the adsorption energy of 5-Fu can be increased or reduced, providing a way to modulate the interaction between the drug and carriers. The study suggests that various MOFs, particularly M-HKUST-1 (M=Sc, V, Cu, and Cr), show promise for delivering 5-Fu. The research provides a novel strategy for screening different MOFs for delivering various drugs. [Extracted from the article]