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54. Effets du niveau d’apport en viande bovine et des procédés de cuisson sur l’environnementluminal colique chez le rat

Author

Pierre, Fabrice H.F., Oberli, Marion, Naud, Nathalie, Fouché, Edwin, Fromentin, Gilles, Tomé, Daniel, Gaudichon, Claire, ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), AgroParisTech-Institut National de la Recherche Agronomique (INRA), Prévention et promotion de la cancérogénèse par les aliments (ToxAlim-PPCA), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), and Institut National de la Recherche Agronomique (INRA)-AgroParisTech

Subjects
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2017

55. Les rats sensibles à l’obésité sous régime faible en lipides et riche en glucides complexes ont un niveau d’expression élevé de l’amylase pancréatique

Author

Even, Patrick, Azzout-Marniche, Dalila, Chaumontet, Catherine, Piedcoq, Julien, Khodorova, Nadezda, Fromentin, Gilles, Gaudichon, Claire, Tomé, Daniel, Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Université Paris Saclay (COmUE), and Groupe Francophone d'Hépatologie-Gastroentérologie et Nutrition Pédiatriques (GFHGNP). FRA.

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2017

56. Modulation of protein status in humans leads top preference for increased portions

Author

Davidenko, Olga, Fromentin, Sébastien, Barbillon, Pierre, Fromentin, Gilles, Tomé, Daniel, Darcel, Nicolas, Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), AgroParisTech-Institut National de la Recherche Agronomique (INRA), MetaGenoPolis, Institut National de la Recherche Agronomique (INRA), Mathématiques et Informatique Appliquées (MIA-Paris), and Institut National de la Recherche Agronomique (INRA)-AgroParisTech

Subjects
[SDV]Life Sciences [q-bio]
Abstract

Modulation of protein status in humans leads top preference for increased portions. Experimental Biology Meeting

Published
2017
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60. Are rodent models fit for investigation of human obesity and related diseases?

Author

Virtue, Sam, Morton, Nicholas M., Fromentin, Gilles, Semple, Robert K., and Even, Patrick C.

Subjects
Alimentation et Nutrition, Food and Nutrition, Médecine humaine et pathologie, Human health and pathology, obesity, disease, rodent models, non-alcoholic fatty liver disease, type 2 diabetes mellitus
Published
2017

61. Striatal and cingulate fMRI responses to unexpected taste reflect behavioral effects of expectations

Author

Davidenko, Olga, Bonny, J.-M., Morrot, Gil, Jean, Betty, Claise, Béatrice, Benmoussa, Abdlatif, Fromentin, Gilles, Tomé, Daniel, Nadkarni, Nachiket A, Darcel, Nicolas, Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Qualité des Produits Animaux (QuaPA), Institut National de la Recherche Agronomique (INRA), Laboratoire Charles Coulomb (L2C), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand, Université Paris-Sud - Paris 11 (UP11), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)

Subjects
[SDV.IDA]Life Sciences [q-bio]/Food engineering, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2016

62. Spatial reorganization of Proopiomelanocortin (POMC)-expressing Neurons in the Arcuate Nucleus of POMC-EGFP Mice Resistant or Prone to Obesity

Author

Tomé, Daniel, Soto, Marion, Chaumontet, Catherine, Guillaumin, Mathilde, Benoit, Simon, Fromentin, Gilles, Andrey, Philippe, Burguet, Jasmine, Darcel, Nicolas, Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Université Paris Saclay (COmUE), Institut National de la Recherche Agronomique (INRA), and Institut Jean-Pierre Bourgin (IJPB)

Subjects
[SDV]Life Sciences [q-bio], [SDV.IDA]Life Sciences [q-bio]/Food engineering, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2016
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63. Obesity-prone high-fat fed rats reduce caloric intake and adiposity and gain more fat-free mass when allowed to separate protein from carbohydrate/fat intake

Author

Tomé, Daniel, Azzout-Marniche, Dalila, Chalvon-Demersay, Tristan, Pimentel, Gregory, Benoit, Simon, Chaumontet, Catherine, Nadkarni, Nachiket, Piedcoq, Julien, Fromentin, Gilles, Gaudichon, Claire, Even, Patrick, Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), AgroParisTech-Institut National de la Recherche Agronomique (INRA), Unité de Recherches Animal et Fonctionnalités des Produits Animaux (URAFPA), Institut National de la Recherche Agronomique (INRA)-Université de Lorraine (UL), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, and Université de Lorraine (UL)-Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2016

65. Control of Food Intake by Dietary Amino Acids and Proteins: Molecular and Cellular Aspects

Author

Fromentin, Gilles, Darcel, Nicolas, Chaumontet, Catherine, Even, P., Tomé, Daniel, Gaudichon, Claire, Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), AgroParisTech-Institut National de la Recherche Agronomique (INRA), Dominique Dardevet, and Institut National de la Recherche Agronomique (INRA)-AgroParisTech

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2016
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67. Structure of protein emulsion in food impacts intestinal microbiota, caecal luminal content composition and distal intestine characteristics in rats

Author

Beaumont, Martin, primary, Jaoui, Daphné, additional, Douard, Véronique, additional, Mat, Damien, additional, Koeth, Fanny, additional, Goustard, Bénédicte, additional, Mayeur, Camille, additional, Mondot, Stanislas, additional, Hovaghimian, Anais, additional, Le Feunteun, Steven, additional, Chaumontet, Catherine, additional, Davila, Anne‐Marie, additional, Tomé, Daniel, additional, Souchon, Isabelle, additional, Michon, Camille, additional, Fromentin, Gilles, additional, Blachier, François, additional, and Leclerc, Marion, additional

Published
2017
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69. Can the modulation of protein digestion kinetics impact satiety?

Author

Gaudichon, Claire, Marsset Baglieri, Agnès, Tomé, Daniel, Fromentin, Gilles, Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), AgroParisTech-Institut National de la Recherche Agronomique (INRA), and Institut National de la Recherche Agronomique (INRA)-AgroParisTech

Subjects
Milk protein fractions, satiety time, digestive, oral, and skin physiology, eggs, postprandial waves, humans, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract

International audience; Many strategies have been implemented to increase satiety of foods and snacks. Because proteins were shown to play a major role on food intake control, many works addressed the effect of the level and the type of proteins on appetite. Milk proteins were especially studied due to the presence of two fractions which digestion kinetics are very different, but results remain controversial. We addressed this question in two studies.In 83 overweight volunteers, we aimed to determine whether casein (slowly digested), whey (rapidly digested) or a combination of both (intermediary kinetic) influenced satiety. Volunteers were divided in 3 parallel groups. Each subject followed two sessions. The first one was a control in which satiety was assessed after the ingestion of a snack containing 60 g of CHO. For the second session, the snack contained 30 g of protein and 30 g of CHO. We thus evaluated the additional effect of proteins compared to CHO only. We also followed the digestion kinetics in a subgroup using intestinal tubes and 15N labeling of proteins. The digestion time was only 2 h with whey, 6 h with caseins and 4h with the mix. In all subjects, proteins increased satiety duration compared to CHO by 18 min, without any effect of the type of proteins despite their important difference in digestion speed. However, a stratified analysis revealed that in subjects with a short satiety duration at control (i.e. after CHO), snacks containing whey were more efficient than casein, increasing satiety time to more than 40 min.We also assessed the satiating effect of eggs cooked as an omelette and cottage cheese in 30 healthy volunteers in a crossover design. Both snacks were comparable regarding energy and nutrient composition. Hormonal profiles (insulin, GIP, and GLP1) as well as plasma urea and amino acids indicated that the omelette was digested slower than cottage cheese. However, satiety duration, energy intake at lunch and appetite ratings were similar after both snacks. We also challenged the association between nutrients and appetite and found unexpected relationships, showing that postprandial waves and appetite may be independent.These two studies show that using protein dose (20-30 g) compatible with supplement strategies, the modulation of kinetics is not a sufficient lever to increase satiety. This conclusion is discussed regarding the existing literature.

Published
2015

70. Sucrose solution intake and its schedule of access affect the response to chronic variable stress in mice

Author

Zeeni, Nadine, Gharibeh, Nathalie, Darcel, Nicolas, Fromentin, Gilles, Tomé, Daniel, Chaumontet, Catherine, Department of Natural Sciences, Lebanese American University (LAU), Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Centre de Recherche en Nutrition Humaine d'Ile-de-France (CRNH-IDF), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Veille Sanitaire (INVS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut National Agronomique Paris-Grignon (INA P-G)-CETAF-Institut National de la Santé et de la Recherche Médicale (INSERM), AgroParisTech-Institut National de la Recherche Agronomique (INRA), Université Paris 13 (UP13)-CETAF-Institut National Agronomique Paris-Grignon (INA P-G)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Institut de Veille Sanitaire (INVS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Veille Sanitaire (INVS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), and HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Institut National Agronomique Paris-Grignon (INA P-G)-CETAF-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV]Life Sciences [q-bio]
Abstract

Sucrose solution intake and its schedule of access affect the response to chronic variable stress in mice. Experimental Biology Meeting

Published
2015

71. High-fat fed rats strongly reduce caloric intake and adiposity gain when allowed to separate protein from fat-carbohydrate intake, with obesity-prone rats also gaining more fat-free mass

Author

Azzout-Marniche, Dalila, Chalvon-Demersay, Tristan, Pimentel, Gregory, Chaumontet, Catherine, Nadkarni, Nachiket, Piedcoq, Julien, Fromentin, Gilles, Tomé, Daniel, Gaudichon, Claire, Even, Patrick, Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Institut National de la Recherche Agronomique (INRA), and AgroParisTech-Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2015

72. The form of energy-containing food alters satiety and fMRI brain responses in humans

Author

Soto, Marion, Darcel, Nicolas, Piedcoq, Julien, Tomé, Daniel, Fromentin, Gilles, Nadkarni, Nachiket, Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Food Nutrition and Eating Behavior, Chaire ANCA, and AgroParisTech-Institut National de la Recherche Agronomique (INRA)

Subjects
nervous system, [SDV]Life Sciences [q-bio], mental disorders, digestive, oral, and skin physiology, psychological phenomena and processes
Abstract

WOS:000361722707116; International audience; We examined the differences in satiety and brain activation after ingestion of apple in the form of juice, puree or slices. 25 normal-weight men had to eat a breakfast consisting of one of three apple products (cross-over design): apple juice, puree or slices, each with the same caloric content. After breakfast, a fMRI session was conducted as follows: a 'liking' run consisting of viewing images (food and objects) whilst rating their appeal value, and a 'choice' run in which participants had to choose between two images of different categories (high-fat/low-fat sweet/savory). Measures of appetite were obtained by using visual analog scales at different times. Consumption of the three apple products led to differences in short-term satiety, in the order slice > puree > juice. In the 'liking' run, the nucleus accumbens (NAcc), the orbitofrontal cortex (OFC) and the hypothalamus were more activated after consumption of apple juice vs. apple slices. Neural activity in the NAcc and OFC was positively correlated with hunger ratings after breakfast. In the 'choice' run, the OFC was more activated after the juice breakfast vs. slices, when subjects chose sweet images (rather than savory) and high-fat images (rather than low-fat). BOLD signal in the OFC measured when high-fat foods were chosen was positively correlated with hunger ratings and ratings of 'expected pleasure to eat' reported after breakfast. These findings suggest that food form elicits differences in short-term satiety, and leads to different responses to food cues in limbic (NAcc and OFC) and homeostatic (hypothalamus) regions underlying food intake.

Published
2015

73. Sucrose solution intake and its schedule of access affect the response to chronic variable stress in mice

Author

Zeeni, Nadine, Gharibeh, Nathalie, Darcel, Nicolas, Fromentin, Gilles, Tome, Daniel, Chaumontet, Catherine, Zeeni, Nadine, Gharibeh, Nathalie, Darcel, Nicolas, Fromentin, Gilles, Tome, Daniel, and Chaumontet, Catherine

Abstract

There is a strong relationship between the intake of calorically-dense palatable food and stress. Moreover, intake of sodas is an important contributory factor to obesity, and is often associated with palatable food consumption. We studied the effects of 2-hour intermittent access to sucrose-sweetened water (SSW, 12.3%, soda-like) and its schedule of administration on the response to chronic variable stress in mice fed a high-fat, high-sugar diet. C57BL/6 mice received access to water or to both water and 2-hour SSW access during 5 weeks, in addition to their diet. After the first two weeks, half of the animals from each group were stressed daily using a chronic variable stress (CVS) paradigm, while the other half were kept undisturbed. During the CVS exposure period, SSW access was either scheduled randomly, right before the stressors or right after the stressor. The effects of SSW and its schedule of administration on stress hormones, adiposity and serum lipids were analyzed. Results showed that SSW access induced an increase in energy intake, body weight gain and abdominal fat as well as attenuation in the response to CVS compared to water access alone. Moreover, there was a greater stress-relieving effect when SSW was administered after exposure to the stressors, compared to random exposure and exposure before the stressors. The present study provides arguments that the availability of intermittent SSW access renders mice more resilient to the effects of CVS, particularly when SSW is provided after exposure to stress.

Published
2017

74. Daily delivery of dietary nitrogen to the periphery is stable in rats adapted to increased protein intake

Author

MORENS, CELINE, GAUDICHON, CLAIRE, FROMENTIN, GILLES, MARSSET-BAGLIERI, AGNES, BENSAID, AHMED, LARUE-ACHAGIOTIS, CHRISTIANE, LUENGO, CATHERINE, and TOME, DANIEL

Subjects
High-protein diet -- Physiological aspects, Amino acids -- Physiological aspects, Biological sciences
Abstract

Dietary nitrogen was traced in rats adapted to a 50% protein diet and given a meal containing 1.50 g [sup.15]N-labeled protein (HP-50 group). This group was compared with rats usually consuming a 14% protein diet and fed a meal containing either 0.42 g (AP-14 group) or 1.50 g (AP-50 group) of [sup.15]N-labeled protein. In the HP group, the muscle nonprotein nitrogen pool was doubled when compared with the AP group. The main adaptation was the enhancement of dietary nitrogen transferred to urea (2.2 [+ or -] 0.5 vs. 1.3 [+ or -] 0.1 mmol N/100 g body wt in the HP-50 and AP-50 groups, respectively). All amino acids reaching the periphery except arginine and the branched-chain amino acids were depressed. Consequently, dietary nitrogen incorporation into muscle protein was paradoxically reduced in the HP-50 group, whereas more dietary nitrogen was accumulated in the free nitrogen pool. These results underline the important role played by splanchnic catabolism in adaptation to a high-protein diet, in contrast to muscle tissue. Digestive kinetics and splanchnic anabolism participate to a lesser extent in the regulation processes. high-protein diet; rats; adaptation; nitrogen-15

Published
2001

75. Pouvoir choisir son aliment : quel impact sur le plaisir de manger et sa consommation ?

Author

Parizel, Odile, Sulmont-Rossé, Claire, Fromentin, Gilles, Delarue, Julien, Marsset-Baglieri, Agnès, Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Centre des Sciences du Goût et de l'Alimentation (CSGA), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Ingénierie Procédés Aliments (GENIAL), and Institut National de la Recherche Agronomique (INRA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-AgroParisTech-Conservatoire National des Arts et Métiers [CNAM] (CNAM)

Subjects
food intake, food liking, food choice, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract

International audience; Introduction et but de l’étude Chaque jour, tout individu est confronté à de nombreux choix alimentaires, de l’acte d’achat jusqu’à la situation de consommation. Il a déjà été démontré qu’un aliment était davantage apprécié quand l’individu pouvait le choisir et que le niveau d’appréciation d’un aliment influençait la quantité consommée. Les objectifs de cette étude ont été de tester : 1. l’influence du choix d’un aliment sur le plaisir de le manger et la quantité consommée, 2. l’influence de la diversité sensorielle entre des produits proposés sur la prise alimentaire. Matériel et méthodes Deux études de protocole identique différant selon les espace-produits ont été réalisées : la première a porté sur 12 purées de pommes variant uniquement selon la texture ; la seconde sur un univers de 12 desserts variant selon plusieurs dimensions sensorielles (texture, couleur, saveur…). Pour chaque étude, 80 volontaires ont été recrutés. Ils ont participé à 3 séances hebdomadaires à l’heure du déjeuner aux cours desquelles un même plat a été servi en amont de la consommation du dessert. Lors de la première séance, les sujets ont attribué une note d’appréciation à chacun des 12 produits. Trois produits d’appréciation similaire ont alors été sélectionnés pour chaque individu. Lors des 2 séances suivantes, chaque sujet a dû choisir un dessert à consommer ad libitum parmi les 3 produits proposés (séance Choix) ou a dû consommer ad libitum un produit imposé parmi les 3 sélectionnés (séance Non-Choix). À chaque séance, les sujets ont attribué une note d’appréciation du dessert consommé et ont évalué leur satisfaction pour le déroulement de la séance ; les quantités consommées ont été également mesurées. Résultats et Analyse statistique Dans les deux études, les notes hédoniques des desserts choisis étaient significativement supérieures en situation de choix qu’en situation de non-choix (étude 1 :pConclusion Lorsque les individus peuvent choisir un aliment pendant leur repas, leur plaisir de manger est augmenté, que ce soit sur l’appréciation du produit choisi ou la satisfaction de l’ensemble du repas. Ce résultat serait associé à une augmentation de la quantité consommée si le choix porte entre des produits dont les différences oro-sensorielles sont importantes. Donner la possibilité de choisir son aliment parmi d’autres pourrait donc être un levier efficace pour inciter les individus à manger des aliments sous-consommés.

Published
2014
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76. Designing a food model to study the impact of food liking on food intake: characterization of isocaloric apple purees varying in texture

Author

Parizel, Odile, Leverrier, Cassandre, Delarue, Julien, Marsset-Baglieri, Agnès, Sulmont-Rossé, Claire, Fromentin, Gilles, Cuvelier, Gerard, Ingénierie, Procédés, Aliments (GENIAL), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Paris-Saclay Food and Bioproduct Engineering (SayFood), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Génie industriel alimentaire (GENIAL), Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut National Agronomique Paris-Grignon (INA P-G)-Ecole Nationale Supérieure des Industries Agricoles et alimentaires, Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), and Leverrier, Cassandre

Subjects
[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, [SDV.IDA]Life Sciences [q-bio]/Food engineering, [SDV.IDA] Life Sciences [q-bio]/Food engineering, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2014

77. Intermittent availability of sugar-sweetened beverages induces different reactions in mice sensitive or resistant to diet-induced obesity

Author

Soto, Marion, Mauduit, Charles-David, Chaumontet, Catherine, Even, Patrick, Fromentin, Gilles, Tomé, Daniel, Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, and AgroParisTech-Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV]Life Sciences [q-bio]
Abstract

WOS:000346646704423; International audience; no abstract

Published
2014

78. Impact of cooking processes on protein digestion in Humans

Author

Oberli, Marion, Marsset-Baglieri, A., Airinei, Gheorghe, Santé-Lhoutellier, Véronique, Remond, Didier, Benamouzig, Robert, Foucault-Simonin, Angélique, Fromentin, Gilles, Tome´, Daniel, Gaudichon, Claire, Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), AgroParisTech-Institut National de la Recherche Agronomique (INRA), Centre de Recherche en Nutrition Humaine, Qualité des produits animaux (UR370) (QuaPA), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Unité de Nutrition Humaine - Clermont Auvergne (UNH), Hôpital Avicenne, Service de Gastroenterologie, Assistance Publique - Hôpitaux de Paris, Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Qualité des Produits Animaux (QuaPA), Institut National de la Recherche Agronomique (INRA), Unité de Nutrition Humaine (UNH), Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université-Institut National de la Recherche Agronomique (INRA), and Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université

Subjects
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2014

79. A positive change in energy balance modulates TrkB expression in the hypothalamus and nodose ganglia of rats

Author

Zeeni, Nadine, Chaumontet, Catherine, Moyse, Emmanuel, Fromentin, Gilles, Tardivel, Catherine, Tome, Daniel, Jean, Andre, Darcel, Nicolas, Zeeni, Nadine, Chaumontet, Catherine, Moyse, Emmanuel, Fromentin, Gilles, Tardivel, Catherine, Tome, Daniel, Jean, Andre, and Darcel, Nicolas

Abstract

Brain-derived neurotrophic factor (BDNF) and its TrkB receptor play critical roles in the synaptic activity and plasticity of mature neurons and enhance adult neurogenesis. Furthermore, treatment with BDNF has been found to attenuate weight gain or even cause weight loss and appetite suppression in rats. The aim of this study was to look at the effect of nutrient intake on BDNF concentrations and cellular proliferation in the brain. Adult male Wistar rats were given one of three diets for 6 weeks: high-carbohydrate, high-fat or high-fat pair-fed diets. Rats were sacrificed at the end of the feeding period and BDNF concentrations in the dorsal vagal complex (DVC), hypothalamus and plasma were measured by ELISA on protein extracts of these samples. Cellular proliferation in the DVC was quantified by Ki-67 immunohistochemistry. Neither BDNF levels nor proliferation were modified by the diet. Secondly, using rats that received the same diets, real-time PCR was performed in the DVC, hypothalamus and nodose ganglia in order to compare TrkB receptor levels. The results showed significantly lower TrkB levels in the hypothalamus and nodose ganglia of fasted rats receiving the high-fat diet when compared to the other groups. These two complementary methodological approaches suggest that there is a relationship between long-term dietary intake and BDNF. More precisely, TrkB expression is more responsive to energy states than to diet composition. An increment in energy stores thus triggers decreased BDNF anorexigenic signaling at the receptor level in the hypothalamus and nodose ganglia, but not in the DVC.

Published
2016

80. Environmental enrichment and cafeteria diet synergistically modify the response to chronic variable stress in rats

Author

Zeeni, Nadine, Bassil, Maya, Daher, Costantine, Ibrahim, Mariana, Zein, Tala, Fromentin, Gilles, Chaumontet, Catherine, Al Nafeesi, Shoug, Zeeni, Nadine, Bassil, Maya, Daher, Costantine, Ibrahim, Mariana, Zein, Tala, Fromentin, Gilles, Chaumontet, Catherine, and Al Nafeesi, Shoug

Abstract

Evidence shows that exposure to environmental enrichment (EE) or to a highly palatable diet can reduce the response to chronic stress in rats. To further explore the relationships between EE, dietary intake and stress, male Sprague-Dawley rats were fed one of two diets for 5 weeks: high carbohydrate (HC) or "Cafeteria" (CAF) (offering a choice of highly palatable cafeteria food). Also, they were housed in cages with or without EE. After the first two weeks, half of the animals from each group were stressed daily using a chronic variable stress (CVS) paradigm, while the other half were kept undisturbed until the end of the experiment. The effects of stress, EE and diet on animal adiposity, serum lipids, and stress hormones were analyzed. Results showed increases in liver weight and intra-abdominal fat associated with the CAF diet and an increase in bodyweight gain associated with both the CAF diet and EE. Stressed animals showed increased serum corticosterone (CORT) levels compared to non-stressed animals (P<0.001). In addition, there was a significant interaction between diet and EE (P=0.02) on serum CORT levels: the CVS-induced increase in CORT was attenuated in the presence of EE and the CAF diet independently and in a synergistic manner. Our study thus provides evidence that the availability of a positive rearing environment combined with highly palatable food renders rats more resilient to the effects of CVS.

Published
2016

82. Obesity-prone high-fat-fed rats reduce caloric intake and adiposity and gain more fat-free mass when allowed to self-select protein from carbohydrate:fat intake

Author

Azzout-Marniche, Dalila, primary, Chalvon-Demersay, Tristan, additional, Pimentel, Grégory, additional, Chaumontet, Catherine, additional, Nadkarni, Nachiket A., additional, Piedcoq, Julien, additional, Fromentin, Gilles, additional, Tomé, Daniel, additional, Gaudichon, Claire, additional, and Even, Patrick C., additional

Published
2016
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84. Obesity‐prone high‐fat fed rats reduce caloric intake and adiposity and gain more fat‐free mass when allowed to separate protein from carbohydrate/fat intake

Author

Tomé, Daniel, primary, Azzout‐Marniche, Dalila, additional, Chalvon‐Demersay, Tristan, additional, Pimentel, Grégory, additional, Chaumontet, Catherine, additional, Nadkarni, Nachiket, additional, Piedcoq, Julien, additional, Fromentin, Gilles, additional, Gaudichon, Claire, additional, and Even, Patrick Christian, additional

Published
2016
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86. Peut-on reproduire un modèle d’obésité sarcopénique chez la souris?

Author

Guelzim, Najoua, Chaumontet, Catherine, Azzout-Marniche, Dalila, Foucault-Simonin, Angélique, Fromentin, Gilles, Tomé, Daniel, Gaudichon, Claire, Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), AgroParisTech-Institut National de la Recherche Agronomique (INRA), and Institut National de la Recherche Agronomique (INRA)-AgroParisTech

Subjects
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2014

87. QTLs influencing carbohydrate and fat choice in a LOU/CxFischer 344 F2 rat population

Author

Marissal-Arvy, Nathalie, Diane, Abdoulaye, Moisan, Marie-Pierre, Larue-Achagiotis, Christiane, Tridon, Claudine, Tomé, Daniel, Fromentin, Gilles, Mormède, Pierre, Nutrition et Neurobiologie intégrée, Institut National de la Recherche Agronomique (INRA), Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), AgroParisTech-Institut National de la Recherche Agronomique (INRA), Nutrition et Neurobiologie intégrée (NutriNeuro), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique, and Institut National de la Recherche Agronomique (INRA)-AgroParisTech

Subjects
Male, [SDV.SA]Life Sciences [q-bio]/Agricultural sciences, Quantitative Trait Loci, Weight Gain, Choice Behavior, Models, Biological, Acyl-CoA Dehydrogenase, Food Preferences, body weight, fat, Dietary Carbohydrates, Animals, rat, Obesity, food behavior, Crosses, Genetic, Behavior, Animal, qtl, Computational Biology, Rats, Inbred Strains, Dietary Fats, Rats, Inbred F344, Rats, carbohydrate, gene network, Female
Abstract

Chantier qualité GA; Objective: Individual differences in macronutrient selection, particularly fat and carbohydrate, and associated body weight gain are partly inherited as polygenic traits, but the potential genetic pathways are unknown. To give an overview of the Quantitative Trait Loci (QTLs) and candidate gene pathways influencing these differences in rat was aimed in this study. Design and Methods: To that end, F2 rats obtained from the crossbreeding between LOU/C and Fischer 344 rat strains to diet self-selection during 3 weeks were submitted. A genome scan was conducted with microsatellite markers covering evenly the whole genome. Genotypes and phenotypes were analyzed separately in male and female F2 rats by multiple interval mapping. Then, lists of candidate genes were treated by the Ingenuity® Pathway software to propose gene pathways involved in our phenotypes. Results: Among numerous others, a QTL on chromosome 12 that influences body weight gain, and fat and carbohydrate choices in the LOU/C x Fischer 344 F2 rat population was found. This locus contains notably the acyl-co-A dehydrogenase gene. Conclusion: A strong genetic determinism and complex pathways involving numerous candidate genes and processes, notably in accordance with the metabolic theory of feeding behavior control were found.

Published
2014
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88. Impact des barèmes de cuisson sur la digestion des protéines de viande chez l'Homme

Author

Oberli, Marion, Marsset-Baglieri, Agnès, Airinei, Gheorge, Sante-Lhoutellier, Veronique, Remond, Didier, Khodorova, Nadezda, Benamouzig, Robert, Foucault, Angelique, Fromentin, Gilles, Tomé, Daniel, Gaudichon, Claire, Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), AgroParisTech-Institut National de la Recherche Agronomique (INRA), Centre d'Investigation Clinique (CIC), Hôpital Avicenne, Qualité des Produits Animaux (QuaPA), Institut National de la Recherche Agronomique (INRA), Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Hôpital Avicenne [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)

Subjects
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract

This abstract has also been published in Cahiers de Nutrition et de Diététique, Volume 48, Supplement 1 (Hors-série 1), December 2013This abstract has also been published in Cahiers de Nutrition et de Diététique, Volume 48, Supplement 1 (Hors-série 1), December 2013; absent

Published
2013
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89. A pilot study for the intrinsic labeling of egg proteins with 15N and 13C

Author

Fromentin, Claire, Sanders, Pascal, Nau, Francoise, Anton, Marc, Fromentin, Gilles, Tomé, Daniel, Thibault, Jean-Noël, Gaudichon, Claire, Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), AgroParisTech-Institut National de la Recherche Agronomique (INRA), Unité de Toxicologie des Contaminants, Laboratoire de Fougères - ANSES, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Science et Technologie du Lait et de l'Oeuf (STLO), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA), Institut National de la Recherche Agronomique (INRA), Systèmes d'Elevage, Nutrition Animale et Humaine (SENAH), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure Agronomique de Rennes, Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Ecole Nationale Supérieure Agronomique de Rennes-Institut National de la Recherche Agronomique (INRA), and French National Research Agency

Subjects
Carbon Isotopes, Nitrogen Isotopes, Egg Proteins, analyse, Pilot Projects, Egg Yolk, volaille, Egg White, aminoacides, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, oeuf, Animals, Female, résidus, Amino Acids, Chickens
Abstract

The aim of this study was to produce intrinsically and uniformly doubly (15)N-(13)C-labeled proteins. These proteins can be used as intrinsic tracers of dietary amino acids, both α-amino groups and carbon skeletons, during postprandial metabolic utilization. Two (Rhodes) laying hens were fed for 16 days with a standard poultry diet supplemented with 0, 0.2% or 0.4% of a mixture of 20 doubly (15)N-(13)C-labeled AAs. A third hen was given a non-enriched diet, as the control. The eggs laid were collected over 24 days, from 3 days before to 4 days after supplementation. The (15)N and (13)C enrichments in proteins from white and yolk were measured by EA-IRMS and GC-C-IRMS for enrichment in individual amino acids. After 10 days of supplementation, the (15)N enrichment reached an isotopic plateau at 1500 to 3000 ‰, depending on the supplementation level, in both white and yolk while the (13)C enrichment was 220 to 650 ‰ in white and was 100 to 250 ‰ in yolk. The (15)N enrichment was similar among the amino acids, except for the aromatic ones in which the enrichment was lower. The δ(13)C values were variable among amino acids in both white and yolk, ranging from 77 ‰ for tyrosine to 555 ‰ for proline with the 0.2 % supplementation level. In conclusion, the incorporation of 0.2 % labeled amino acids in the hen diet allowed us to achieve sufficient enrichment for metabolic studies. However, due to the non-homogeneity of the (13)C labeling, adequate (13)C enrichment of individual amino acids must be considered depending on the investigated metabolic pathway.

Published
2012
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90. MOESM1 of The Calm Mouse: An Animal Model of Stress Reduction

Author

Gurfein, Blake, Stamm, Andrew, Bacchetti, Peter, Dallman, Mary, Nachiket Nadkarni, Milush, Jeffrey, Touma, Chadi, Palme, Rupert, Borgo, Charles, Fromentin, Gilles, Lown-Hecht, Rachel, Konsman, Jan, Acree, Michael, Premenko-Lanier, Mary, Darcel, Nicolas, Hecht, Frederick, and Nixon, Douglas

Abstract

Supplementary material, approximately 1.96 MB.

Published
2012
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91. A satiating message influences appetite but not food intake in high disinhibited low restraint women

Author

Lesdema, Aurélie, Fromentin, Gilles, Arlotti, A., Vinoy, S., Tomé, Daniel, Marsset-Baglieri, Agnès, Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), AgroParisTech-Institut National de la Recherche Agronomique (INRA), Kraft Foods Europe R&D Biscuit, and Institut National de la Recherche Agronomique (INRA)-AgroParisTech

Subjects
appetite, message, restraint, [SDV]Life Sciences [q-bio], satiety, disinhibition
Abstract

absent

Published
2011

92. Leucine and branched-chain amino acids modulate translation in rat primary hepatocytes

Author

SINGER, Dustin, Chotechuang, Nattida, Chaumontet, Catherine, Gaudichon, Claire, Fromentin, Gilles, Tomé, Daniel, Azzout-Marniche, Dalila, Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, and AgroParisTech-Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV]Life Sciences [q-bio]
Abstract

We have previously demonstrated that high amino acids (AA) and insulin are required for stimulation of translation in hepatocytes. Three hepatic sensing pathways are regulated by dietary protein, i.e. mTOR, GCN2 and AMPK. However, the nature of the AA signal is still unknown. We aimed to identify this signal and clarify the relationship between the transduction pathways using primary hepatocyte culture. We examined the role of branched-chain amino acids (BCAA) and L-leucine (Leu) in these pathways. With similar findings to the ones we obtained upon high AA treatment, BCAA or Leu stimulated phosphorylation of mTOR, 4E-BP1 and S6K1 and decreased phosphorylation of AMPK and GCN2. We further characterized the roles of mTOR and AMPK in the pathway by using AICAR, an activator of AMPK, and rapamycin, an inhibitor of mTOR. Our results show that AICAR not only induced AMPK phosphorylation with or without insulin, but also decreased mTOR phosphorylation. Rapamycin treatment further decreased mTOR phosphorylation. Surprisingly, 4E-BP1, a well known target of mTOR was dramatically decreased by AICAR, but not by rapamycin. These results suggest that BCAA and Leu are the key amino acids sensed by hepatocytes, and that AMPK may act as a general switch during high AA thereby controlling protein synthesis. To characterize the hierarchy of the system more in detail we next aim to identify the protein phosphatases induced by high AA.

Published
2011

94. The satiating effect of egg is higher than fresh cheese when given as isocaloric 'solid' preloads in humans

Author

Marsset-Baglieri, Agnès, Diouani, Aldjia, Fromentin, Gilles, Airinei, Gheorghe, Benamouzig, Robert, Nau, Francoise, Tomé, Daniel, Gaudichon, Claire, Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), AgroParisTech-Institut National de la Recherche Agronomique (INRA), Centre de Recherche en Nutrition Humaine, Science et Technologie du Lait et de l'Oeuf (STLO), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Institut National de la Recherche Agronomique (INRA)-AgroParisTech, and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)

Subjects
[SDV]Life Sciences [q-bio], digestive, oral, and skin physiology
Abstract

Proteins are usually considered to have a specific satiating effect but the differences between different protein sources are unclear. The objective was to compare the satiating effect of two isocaloric "solid" preloads containing egg or milk protein (omelette or fresh cheese), and to relate this effect to plasma metabolites and hormones variations. 30 subjects participated to 2 randomised test days, one per preload. On each test day, after consumption of the whole prelaod (322kcal; 26g proteins, 21g lipids, 7.5g lactose), their appetite sensations were recorded until they asked for the next meal. The delay between the preload and the next meal as well as the spontaneous energy intake at the meal were measured. In 10 volunteers, blood samples were taken during the same time in order to measure plasma concentrations of energy metabolites and satiety hormones. The two products displayed no difference for the delay between the preload and the meal, but the omelette reduced significantly the energy intake at the meal by 300 kcal in comparison to the fresh cheese. Subjects reported to feel less hunger with the omelette. GIP and insulin secretions and uremia increased significantly after the fresh cheese but not the omelette, while glucagon and GLP-1 secretions displayed delayed profiles with the omelette. We conclude that eggs present a more satiating effect than a fresh dairy product on the basis of a decreased energy intake. Uremia and hormone profiles suggest that this effect is mainly due to a slower digestion rate, caused by a different structure of the food.

Published
2011

95. Processing modifies in vitro egg protein digestibility as well as protein efficiency ratio and body composition in rats

Author

Gaudichon, Claire, Fromentin, Gilles, Piedcoq, Julien, Tomé, Daniel, Dupont, Didier, Guérin-Dubiard, Catherine, Lechevalier-Datin, Valérie, Nau, Francoise, Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Science et Technologie du Lait et de l'Oeuf (STLO), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)

Subjects
procédé industriel, protéine, oeuf, [SDV.IDA]Life Sciences [q-bio]/Food engineering, digestion, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2011

96. Assessement of the nutritional quality of egg proteins in humans using intrinsic and uniformly doubly [15N]-[13C]- labelling

Author

Fromentin, Claire, Gaudichon, Claire, Thibault, Jean-Noel, Anton, Marc, Tomé, Daniel, Nau, Francoise, Roudaut, B., Fromentin, Gilles, Sanders, P., Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Systèmes d'élevage, nutrition animale et humaine (SENAH), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA), Institut National de la Recherche Agronomique (INRA), Science et Technologie du Lait et de l'Oeuf (STLO), and Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)

Subjects
protéine, qualité, oeuf, [SDV.IDA]Life Sciences [q-bio]/Food engineering, santé humaine, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2011

97. Protéines laitières et satiété, contrôle du comportement alimentaire

Author

Fromentin, Gilles, Darcel, Nicolas, Lesdema, Aurélie, Rasoamanana, Rojo, Chaumontet, Catherine, Gaudichon, Claire, Tomé, Daniel, Marsset-Baglieri, Agnès, Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, and AgroParisTech-Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV.SA]Life Sciences [q-bio]/Agricultural sciences, satiete, comportement alimentaire, protéines laitières, satiété, peptides laitiers, macronutriment
Abstract

Si le caractère sur-satiétogène des protéines par rapport aux autres macronutriments est avéré, les mécanismes mis en jeu dans l’apparition de cet effet demeurent cependant incertains et sujet à débat. En outre, la modulation de l’effet satiétogène selon la nature des protéines utilisées et leurs effets sur les mécanismes d’action demeurent controversés. L’objectif de cette revue est de faire le point sur i) les conséquences de l’ingestion des protéines alimentaires sur la satiété, ii) les mécanismes périphériques et iii) les mécanismes centraux à l’origine de la satiété induite par l’ingestion des protéines alimentaires. Dans ces trois parties nous étudierons la modulation de ces effets selon la nature des protéines alimentaires et plus particulièrement pour les protéines laitières. Nous développerons le cas des protéines de lactosérum, notamment l’α-lactalbumine et la β-lactoglobuline en comparaison avec la caséine et/ou les protéines totales du lait. Dans le domaine des peptides bio-actifs d’origine laitière, nous exposerons les études concernant le caséinomacropeptide (CMP). L’ensemble de ces résultats montre que l’effet satiétogène des protéines, notamment laitières, pourrait être exploité, notamment dans des programmes de perte de poids car la consommation de repas hyperprotéiques semble permettre de diminuer les sensations de faim et donc d’améliorer le bien-être des personnes en phase d’amaigrissement., Dietary factors that may modulate appetite and energy intake are major targets for the intervention aiming at prevention and treatment of overweight and obesity. However, the roles of the various macronutrients in the qualitative and quantitative control of food intake need to be further assessed. Despite numerous studies showing that proteins are the macronutrients with the most important satiety effect, there are still some uncertainties and the mechanisms involved are not clearly identified. The purpose of this review is to describe i) the consequences of ingestion of dietary protein on satiety and long-term weight control of the individual, ii) the peripheral and iii) the central mechanisms responsible for satiety induced by dietary proteins. Moreover we will detail the impact of the type of protein ingested and specifically milk proteins, which are of particular interest because of their nutritional and functional properties, on the control of food intake. We will develop the case of whey protein, including α-lactalbumin and β-lactoglobulin, as compared to casein or total milk protein. In the field of bioactive milk peptides we report the studies on caseinomacropeptide (CMP). All these results show that the satiating effect of proteins, especially dairy proteins, can be exploited in programs for weight loss because consumption of high protein meals seems to reduce feelings of hunger and thus improve the welfare of people in the process of weight loss.

Published
2011

98. Dietary proteins poorly contribute to the endogenous production of Glucose after egg ingestion in humans

Author

Fromentin, Claire, Gaudichon, Claire, Nau, Francoise, Sanders, P., Diouani, A., Flet, L., Fromentin, Gilles, Tomé, Daniel, Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), AgroParisTech-Institut National de la Recherche Agronomique (INRA), Science et Technologie du Lait et de l'Oeuf (STLO), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Centre Hospitalier Universitaire de l'Hôtel Dieu (CHU Hôtel Dieu), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)

Subjects
gluconeogenesis, [SDV]Life Sciences [q-bio], embryonic structures, digestive, oral, and skin physiology, [SDV.IDA.SMA]Life Sciences [q-bio]/Food engineering/domain_sdv.ida.sma, stable isotopes, egg proteins, humans, postprandial state
Abstract

Dietary proteins poorly contribute to the endogenous production of Glucose after egg ingestion in humans

Published
2011

99. À énergie égale, un en-cas à base d’oeuf est plus satiétogène qu’un en-cas à base de fromage blanc chez l’Homme

Author

Djiouani, A., Gaudichon, Claire, Fromentin, Gilles, Airinei, G., Benamouzig, R., Nau, Francoise, Tomé, Daniel, Marsset Baglieri, Agnès, Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Centre de Recherche en Nutrition Humaine d'Ile-de-France (CRNH-IDF), Université Paris 13 (UP13)-CETAF-Institut National Agronomique Paris-Grignon (INA P-G)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut de Veille Sanitaire (INVS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Science et Technologie du Lait et de l'Oeuf (STLO), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), AgroParisTech-Institut National de la Recherche Agronomique (INRA), Université Paris 13 (UP13)-CETAF-Institut National Agronomique Paris-Grignon (INA P-G)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Institut de Veille Sanitaire (INVS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Veille Sanitaire (INVS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), and HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Institut National Agronomique Paris-Grignon (INA P-G)-CETAF-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
alimentation, nutrition, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, protéine, pouvoir satiétogène, oeuf, [SDV.IDA]Life Sciences [q-bio]/Food engineering, satiété, fromage, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract

Introduction et But de l’étude. – Parmi les aliments, ceux riches en protéines pourraient présenter un effet satiétogène plus important. Contrairement aux protéines de lait, les protéines d’œuf ont rarement été l’objet d’études nutritionnelles ces dernières années. Leur pouvoir satiétogène est mal caractérisé et les seules études menées à ce sujet suggèrent que les protéines du blanc pourraient présenter un très faible pouvoir satiétogène contrairement aux protéines d’œuf entier. L’étude présentée ici s’est attachée à évaluer chez l’Homme les effets satiétogènes de la consommation d’un en-cas à base d’œuf entier, en comparaison à un en-cas à base de fromage blanc, en lien avec les vagues métaboliques postprandiales et les sécrétions hormonales associées à la consommation de ces en-cas.Matériel et Méthodes. – Trente sujets, âgés de 26,8 ± 5,9 ans et d’IMC 22,7 ± 1,7 kg/m2, ont participé à 2 jours de tests randomisés, un par en-cas (omelette ou fromage blanc). Les en-cas apportaient chacun 332 kcal, 26 g de protéines, 21 g de lipides et 7,5 g de lactose. L’évolution des sensations d’appétit et le délai entre la prise de l’en-cas et la demande spontanée du repas suivant ont été mesurés, ainsi que la prise énergétique lors de ce repas. Des prises de sang ont été effectuées sur un sous-groupe de 10 sujets après ingestion des en-cas jusqu’à la demande du repas. Les concentrations plasmatiques en glucose, triglycérides, cholestérol, urée, insuline, glucagon, ghréline, GLP-1, GIP, et PYY ont été déterminées.Résultats. – Le délai entre la prise de l’en-cas et la demande spontanée du repas suivant n’a pas été influencé par la nature de l’en-cas, mais l’omelette a réduit significativement la prise alimentaire au déjeuner suivant par rapport au fromage blanc (663 ± 42 kcal contre 964 ± 64 kcal) (P < 0,0001). Les sujets ont eu une sensation de faim moins importante avec l’omelette qu’avec le fromage blanc. Inversement, la sensation de satiété avait tendance à diminuer moins rapidement avec l’omelette qu’avec le fromage blanc. Aucune différence significative n’a été observée entre les deux en-cas pour les concentrations plasmatiques en glucose, cholestérol et triglycérides, alors que l’urémie augmentait significativement après le fromage blanc. Les sécrétions de GIP et d’insuline ont été augmentées après le fromage blanc mais pas après l’omelette, alors que les sécrétions de GLP-1 et de glucagon ont été prolongées plus longtemps après l’omelette qu’avec le fromage blanc.Conclusion. – Nous avons mis en évidence un effet satiétogène des protéines d’œuf plus important que les protéines de lait sur la base d’une diminution de la prise alimentaire. Cependant, nous n’avons pas observé de différence au niveau du délai entre la prise de l’en-cas et la demande du repas. Les profils métaboliques (urémie stable) et hormonaux (GLP-1 et glucagon sécrétés plus longtemps) laissent à penser que cet effet est dû à une différence de vitesse de digestion plus lente avec l’omelette qu’avec le fromage blanc, probablement du fait de la différence de structure des en-cas.

Published
2010

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