905 results on '"Egeo A"'
Search Results
52. Non-invasive Vagus Nerve Stimulation (nVNS) as mini-prophylaxis for menstrual/menstrually related migraine: an open-label study
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Grazzi, Licia, Egeo, Gabriella, Calhoun, Anne H., McClure, Candace K., Liebler, Eric, and Barbanti, Piero
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- 2016
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53. Erenumab in the prevention of high‐frequency episodic and chronic migraine: Erenumab in Real Life in Italy (EARLY), the first Italian multicenter, prospective real‐life study
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Francesco Bono, Piero Barbanti, Fabrizio Vernieri, Gabriella Egeo, Bruno Mercuri, Massimo Filippi, Cinzia Aurilia, Antonio Salerno, Licia Grazzi, Sabina Cevoli, Fabio Frediani, Antonio Carnevale, Bruno Colombo, Luisa Fofi, Claudia Altamura, Barbanti, P., Aurilia, C., Egeo, G., Fofi, L., Cevoli, S., Colombo, B., Filippi, M., Frediani, F., Bono, F., Grazzi, L., Salerno, A., Mercuri, B., Carnevale, A., Altamura, C., and Vernieri, F.
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Adult ,Male ,medicine.medical_specialty ,Visual analogue scale ,Migraine Disorders ,Population ,Effectiveness ,Antibodies, Monoclonal, Humanized ,03 medical and health sciences ,0302 clinical medicine ,Chronic Migraine ,Cost of Illness ,Calcitonin Gene-Related Peptide Receptor Antagonists ,Interquartile range ,Internal medicine ,Outcome Assessment, Health Care ,medicine ,Clinical endpoint ,Humans ,Prospective Studies ,030212 general & internal medicine ,education ,Migraine ,Pain Measurement ,education.field_of_study ,business.industry ,Real-life ,Middle Aged ,medicine.disease ,Treatment ,Italy ,Neurology ,Tolerability ,Calcitonin gene-related peptide ,Cohort ,Female ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,Erenumab - Abstract
Objective: To assess the effectiveness, safety, and tolerability of erenumab in a real-life migraine population, while trying to identify responsiveness predictors. Background: Erenumab is a fully human Ig-2 monoclonal antibody blocking the calcitonin gene-related peptide receptor, indicated for migraine prophylaxis. Phase II and III trials demonstrated that erenumab is effective, safe, and well tolerated in the prevention of episodic and chronic migraine (CM), showing an early onset of action. Methods: This is a multicenter, prospective, cohort, and real-life study. We considered for enrolment all consecutive patients aged 18–65 affected by high-frequency episodic migraine (HFEM) or CM, with or without medication overuse, visited at nine Italian Headache Centers from December 20, 2018 to September 30, 2019. Each patient was treated with erenumab 70mg, administered subcutaneously every 4weeks. Treatment duration was planned to last from 6 to 12months, depending on the patient's response. The primary endpoint was the change in monthly migraine days (MMDs) at weeks 9–12 compared to baseline. Secondary endpoints included changes in monthly analgesics intake, ≥50%, ≥75%, and 100% responder rates and any variation in the Visual Analog Scale (VAS) and Headache Impact Test scores (HIT). Results: In total, 372 migraine patients were treated with at least one dose of erenumab 70mg. At weeks 9–12, erenumab decreased MMDs by 4.5±4.1days (mean±SD) in patients with HFEM and by 9.3±9.1 (mean±SD) days in those with CM compared to baseline. At weeks 9–12 VAS score was reduced by 1.9±1.9 (mean±SD), HIT score by 10.7±8.8 (mean±SD), and median monthly analgesics intake passed from 12.0 (interquartile range [IQR] 10.0–14.0) to 5.0 (IQR 3.0–7.0) in HFEM. In CM patients, VAS was reduced by 1.7±2.0 (mean±SD), HIT by 9.7±10.4 (mean±SD), and median monthly analgesics intake passed from 20.0 (IQR 15.0–30.0) to 8.0 (IQR 5.0–15.0). At week 12, ≥50% responders were 60/101 (59.4%) for HFEM and 146/263 (55.5%) for CM, ≥75% responders were 17/101 (16.8%) and 59/263 (22.4%) and 100% responders 1/101 (1.0%) and 3/263 (1.1%), respectively. Erenumab responsiveness in HFEM was positively associated with unilateral pain localization (OR: 3.03, 95% CI: 1.24–7.40; p=0.015), whereas in CM responsiveness was positively associated with and baseline migraine frequency (OR: 1.06, 95% CI:1.02–1.11; p=0.031), dopaminergic symptoms (OR: 2.01, 95% CI: 1.14–3.52; p=0.015), and negatively associated with psychiatric comorbidities (OR: 0.43, 95% CI: 0.20–0.93; p=0.003). Conclusions: Erenumab 70mg is effective, safe, and well tolerated in real life. Easily obtainable clinical features might be of help in predicting patient's responsiveness.
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- 2020
54. Association of LTA and SOD Gene Polymorphisms with Cerebral White Matter Hyperintensities in Migraine Patients
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Ferroni, Patrizia, primary, Palmirotta, Raffaele, additional, Egeo, Gabriella, additional, Aurilia, Cinzia, additional, Valente, Maria Giovanna, additional, Spila, Antonella, additional, Pierallini, Alberto, additional, Barbanti, Piero, additional, and Guadagni, Fiorella, additional
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- 2022
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55. Suggestive linkage of familial mesial temporal lobe epilepsy to chromosome 3q26
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Fanciulli, Manuela, Di Bonaventura, Carlo, Egeo, Gabriella, Fattouch, Jinane, Dazzo, Emanuela, Radovic, Slobodanka, Spadotto, Alessandro, Giallonardo, Anna Teresa, and Nobile, Carlo
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- 2014
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56. Locking down the CGRP pathway during the COVID-19 pandemic lockdown: the PandeMig study
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Adriana Fallacara, Sabina Cevoli, Paola Torelli, Claudia Altamura, Gabriella Egeo, Piero Barbanti, Giulia Pierangeli, Cinzia Aurilia, Fabrizio Vernieri, Umberto Pensato, Nicoletta Brunelli, Luisa Fofi, Valentina Favoni, Altamura C., Cevoli S., Aurilia C., Egeo G., Fofi L., Torelli P., Brunelli N., Pierangeli G., Favoni V., Fallacara A., Pensato U., Barbanti P., and Vernieri F.
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Male ,Neurology ,Longitudinal Studie ,Cohort Studies ,0302 clinical medicine ,Migraine Disorder ,Surveys and Questionnaires ,Pandemic ,Longitudinal Studies ,030212 general & internal medicine ,CGRP ,General Medicine ,Middle Aged ,Psychiatry and Mental health ,Italy ,Cohort ,Quarantine ,Female ,Neurosurgery ,Coronavirus Infections ,Cohort study ,Human ,Adult ,medicine.medical_specialty ,Calcitonin Gene-Related Peptide Receptor Antagonist ,Migraine Disorders ,Pneumonia, Viral ,Clinical Neurology ,Dermatology ,Calcitonin gene-related peptide ,Antibodies, Monoclonal, Humanized ,03 medical and health sciences ,Calcitonin Gene-Related Peptide Receptor Antagonists ,Internal medicine ,medicine ,Humans ,Pandemics ,Migraine ,business.industry ,Coronavirus Infection ,COVID-19 ,medicine.disease ,Galcanezumab ,Presenteeism ,Neurology (clinical) ,Cohort Studie ,business ,030217 neurology & neurosurgery ,Erenumab - Abstract
Objectives: The COVID-19 pandemic and the consequent lockdown came as a storm disrupting people’s everyday life. This study aimed at observing whether the COVID-19 related lockdown influenced migraine frequency and disability in migraine patients on therapy with monoclonal antibodies inhibiting the CGRP pathway. Methods: In this longitudinal observational cohort study, 147 consecutive patients receiving monthly administration of erenumab or galcanezumab were enrolled in four Italian headache centers. All patients filled a questionnaire concerning working and household settings, recent flu symptoms or COVID-19 diagnosis, and family loss due to COVID-19 infection. Monthly migraine days (MMDs), monthly painkiller intake (MPI), and HIT-6 disability relative to the first month of lockdown imposition (T-lock) and the month before (T-free) were also collected. Results: From T-free to T-lock, the cohort displayed a reduction in MMDs (from 10.5 ± 7.6 to 9.8 ± 7.6, p =.024) and HIT-6 scores (from 59.3 ± 8.3 men reduced MPI more frequently than women (p =.005). Conclusions: Our study observed that the lockdown impact to 57.8 ± 8.8, p=.009), while MPI resulted unchanged (from 11.6 ± 11.5 to 11.1 ± 11.7; p =.114). MMDs, MPI, and HIT-6 variations from T-free to T-lock did not differ according to work settings or household. Patients beyond the first 3 months of therapy presented less often a reduction in MMDs (p =.006) and on everyday life did not affect the migraine load in patients receiving monoclonal antibodies inhibiting the CGRP pathway. Patients in the first months of therapy experienced a greater improvement according to drug pharmacokinetics, while women more frequently needed rescue medications, possibly indicating presenteeism or cephalalgophobia.
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- 2020
57. Predictors of response to onabotulinumtoxin A in chronic migraine
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Barbanti, P. and Egeo, G.
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- 2018
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58. Non-invasive vagus nerve stimulation (nVNS) as symptomatic treatment of migraine in young patients: a preliminary safety study
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Grazzi, Licia, Egeo, Gabriella, Liebler, Eric, Padovan, Anna Maria, and Barbanti, Piero
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- 2017
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59. Look beyond Catechol-O-Methyltransferase genotype for cathecolamines derangement in migraine: the BioBIM rs4818 and rs4680 polymorphisms study
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De Marchis, Maria Laura, Barbanti, Piero, Palmirotta, Raffaele, Egeo, Gabriella, Aurilia, Cinzia, Fofi, Luisa, Piroso, Serena, Ialongo, Cristiano, Della-Morte, David, D’Andrea, Giovanni, Ferroni, Patrizia, and Guadagni, Fiorella
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- 2015
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60. Non-invasive vagus nerve stimulation for acute treatment of high-frequency and chronic migraine: an open-label study
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Barbanti, Piero, Grazzi, Licia, Egeo, Gabriella, Padovan, Anna Maria, Liebler, Eric, and Bussone, Gennaro
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- 2015
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61. A case-control study on excessive daytime sleepiness in chronic migraine
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Barbanti, Piero, Aurilia, Cinzia, Egeo, Gabriella, Fofi, Luisa, and Vanacore, Nicola
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- 2013
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62. Conversion from chronic to episodic migraine in patients treated with galcanezumab in real life in Italy: the 12-month observational, longitudinal, cohort multicenter GARLIT experience
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Claudia, Altamura, Nicoletta, Brunelli, Marilena, Marcosano, Cinzia, Aurilia, Gabriella, Egeo, Carlo, Lovati, Valentina, Favoni, Armando, Perrotta, Ilaria, Maestrini, Francesca, Schiano Di Cola, Florindo, d'Onofrio, Cinzia, Finocchi, Davide, Bertuzzo, Francesco, Bono, Angelo, Ranieri, Maria, Albanese, Roberta, Messina, Alberto, Doretti, Vittorio, Di Piero, Sabina, Cevoli, Piero, Barbanti, Fabrizio, Vernieri, and Gianluca, Demirtzidis
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Cohort Studies ,Treatment Outcome ,Double-Blind Method ,Migraine Disorders ,Humans ,Antibodies, Monoclonal, Humanized - Abstract
To investigate in real-life the conversion from chronic migraine (CM) to episodic migraine (EM), specifically to EM with High-Frequency (HFEM: 8-14 monthly migraine days, MMDs), Medium-Frequency (MFEM, 4-7 MMDs), and Low-Frequency EM (LFEM, 0-3 MMDs), and its persistence during 1 year of treatment with galcanezumab.Consecutive CM patients treated with galcanezumab completing 1 year of observation were enrolled. We collected data on MMDs, pain intensity (Numeric Rating Scale, NRS score), and monthly acute medication intake (MAMI) from baseline (V1) to the 12-month visit (V12).Of the 155 enrolled patients, 116 (around 75%) reverted to EM at every visit and 81 (52.3%) for the entire 1-year treatment. Patients with older onset age (p = 0.010) and fewer baseline MMDs (p = 0.005) reverted more frequently to EM. At V12, 83 participants (53.5%) presented MFEM or LFEM. Patients reverted to MFEM or LFEM for 7 months (25th 1, 75th 11). The medication overuse discontinuation rate at V12 was 82.8% and occurred for 11 months (25th 8, 75th 12). From baseline to V12, the MAMI decreased by 17 symptomatic drugs (p 0.000001) while the NRS score reduced by almost 2 points (p 0.000001). A consistent transition to EM for the entire treatment year was observed in 81 (52.3%) patients.The 1-year GARLIT experience suggests that more than half of CM patients treated with galcanezumab persistently reverted to EM in real life.ClinicalTrials.gov NCT04803513.
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- 2022
63. Migraine as a Cortical Brain Disorder
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Gabriella Egeo, Marcello Silvestro, Filippo Brighina, Antonio Russo, Vincenzo Di Stefano, Piero Barbanti, Barbanti P., Brighina F., Egeo G., Di Stefano V., Silvestro M., Russo A., Barbanti, P., Brighina, F., Egeo, G., Di Stefano, V., Silvestro, M., and Russo, A.
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Sensory processing ,medicine.medical_treatment ,Migraine Disorders ,Amygdala ,03 medical and health sciences ,0302 clinical medicine ,Neuroimaging ,medicine ,Humans ,Ictal ,migraine ,030212 general & internal medicine ,pathophysiology ,neuroimaging ,business.industry ,Trigeminovascular system ,medicine.disease ,medicine.anatomical_structure ,Neurology ,Migraine ,Cerebral cortex ,Cortical Excitability ,cerebral cortex ,Settore MED/26 - Neurologia ,Neurology (clinical) ,Brainstem ,Nerve Net ,neurophysiology ,business ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Purpose Migraine is an exclusively human chronic disorder with ictal manifestations characterized by a multifaceted clinical complexity pointing to a cerebral cortical involvement. The present review is aimed to cover the clinical, neuroimaging, and neurophysiological literature on the role of the cerebral cortex in migraine pathophysiology. Overview Converging clinical scenarios, advanced neuroimaging data, and experimental neurophysiological findings, indicate that fluctuating excitability, plasticity, and metabolism of cortical neurons represent the pathophysiological substrate of the migraine cycle. Abnormal cortical responsivity and sensory processing coupled to a mismatch between the brain's energy reserve and workload may ignite the trigeminovascular system, leading to the migraine attack through the activation of subcortical brain trigeminal and extra-trigeminal structures, and driving its propagation and maintenance. Discussion The brain cortex emerges as the crucial player in migraine, a disorder lying at the intersection between neuroscience and daily life. Migraine disorder stems from an imbalance in inhibitory/excitatory cortical circuits, responsible for functional changes in the activity of different cortical brain regions encompassing the neurolimbic-pain network, and secondarily allowing a demodulation of subcortical areas, such as hypothalamus, amygdala, and brainstem nuclei, in a continuous mutual crosstalk.
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- 2020
64. Applications of Ketogenic Diets in Patients with Headache: Clinical Recommendations
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Giulia Pierangeli, Gianluca Coppola, Giacomo D’Arrigo, Giulio Sirianni, Piero Barbanti, Cherubino Di Lorenzo, Nicoletta Rebaudengo, Giovanni Spera, Fabio Frediani, Giovanna Ballerini, Maria Pia Prudenzano, Mackenzie C. Cervenka, Gabriella Egeo, Andrea Bernardini, Riccardo Garbo, Grazia Semeraro, Mariarosaria Valente, Di Lorenzo C., Ballerini G., Barbanti P., Bernardini A., D'arrigo G., Egeo G., Frediani F., Garbo R., Pierangeli G., Prudenzano M.P., Rebaudengo N., Semeraro G., Sirianni G., Valente M., Coppola G., Cervenka M.C., and Spera G.
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0301 basic medicine ,medicine.medical_specialty ,ketosis ,Cluster headache ,ketones ,medicine.medical_treatment ,ketogenic diets ,Review ,Ketosi ,03 medical and health sciences ,Epilepsy ,0302 clinical medicine ,medicine ,Humans ,In patient ,migraine ,TX341-641 ,Intensive care medicine ,Nutrition and Dietetics ,clinical recommendations ,cluster headache ,headache ,business.industry ,Nutrition. Foods and food supply ,Ketogenic diet ,medicine.disease ,Ketone ,Clinical Practice ,030104 developmental biology ,Migraine ,Practice Guidelines as Topic ,Headaches ,medicine.symptom ,Ketosis ,Diet, Ketogenic ,business ,030217 neurology & neurosurgery ,Clinical recommendation ,Human ,Food Science - Abstract
Headaches are among the most prevalent and disabling neurologic disorders and there are several unmet needs as current pharmacological options are inadequate in treating patients with chronic headache, and a growing interest focuses on nutritional approaches as non-pharmacological treatments. Among these, the largest body of evidence supports the use of the ketogenic diet (KD). Exactly 100 years ago, KD was first used to treat drug-resistant epilepsy, but subsequent applications of this diet also involved other neurological disorders. Evidence of KD effectiveness in migraine emerged in 1928, but in the last several year’s different groups of researchers and clinicians began utilizing this therapeutic option to treat patients with drug-resistant migraine, cluster headache, and/or headache comorbid with metabolic syndrome. Here we describe the existing evidence supporting the potential benefits of KDs in the management of headaches, explore the potential mechanisms of action involved in the efficacy in-depth, and synthesize results of working meetings of an Italian panel of experts on this topic. The aim of the working group was to create a clinical recommendation on indications and optimal clinical practice to treat patients with headaches using KDs. The results we present here are designed to advance the knowledge and application of KDs in the treatment of headaches.
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- 2021
65. Automated pipeline for the analysis of a scale-reduced steel cable net
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Universitat Politècnica de Catalunya. Doctorat en Enginyeria de la Construcció, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. ATEM - Anàlisi i Tecnologia d'Estructures i Materials, Universitat Politècnica de Catalunya. EGEO - Enginyeria Geomàtica, Ramonell Cazador, Carlos, Chacón Flores, Rolando Antonio, Krenn, Burkhard, Puig i Polo, Càrol, Universitat Politècnica de Catalunya. Doctorat en Enginyeria de la Construcció, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. ATEM - Anàlisi i Tecnologia d'Estructures i Materials, Universitat Politècnica de Catalunya. EGEO - Enginyeria Geomàtica, Ramonell Cazador, Carlos, Chacón Flores, Rolando Antonio, Krenn, Burkhard, and Puig i Polo, Càrol
- Abstract
This paper proposes a digitally twinned experimental analysis of a scale-reduced laboratory-sized steel cable net subjected to vertical loading. The test is aimed at establishing automated pipelines of information and analysis between the measurements (displacements of nodes) and the numerical model of the cable net, which are seamlessly interconnected through a BIM model. These automated pipelines erect the frame of the development of a digital twin of the cable net with structural analysis purposes. For the sake of measurements, a terrestrial laser scanner is used. Displacements of the nodes are extracted using computational geometry tools. For the sake of analysis, a data-based numerical model is proposed to obtain the tensile state of the cables. Precisely understanding the force distribution along nets is a challenge at design, construction and operation stages. This research belongs to a vaster project related to the development of automated pipelines of information for European infrastructure in the form of digital twins. The outcome of this laboratory test results is of great use when developing similar automated pipelines of information in real sites including cable nets in roofs., All authors acknowledge the funding of ASHVIN, “Assistants for Healthy, Safe, and Productive Virtual Construction Design, Operation & Maintenance using a Digital Twin” an H2020 project under agreement 958161., Objectius de Desenvolupament Sostenible::9 - Indústria, Innovació i Infraestructura, Postprint (published version)
- Published
- 2022
66. Geometrical digital twinning of a tapered, horizontally curved composite box girder bridge
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Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. Doctorat en Enginyeria de la Construcció, Universitat Politècnica de Catalunya. ATEM - Anàlisi i Tecnologia d'Estructures i Materials, Universitat Politècnica de Catalunya. EGEO - Enginyeria Geomàtica, Chacón Flores, Rolando Antonio, Ramonell Cazador, Carlos, Puig i Polo, Càrol, Mirambell Arrizabalaga, Enrique, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. Doctorat en Enginyeria de la Construcció, Universitat Politècnica de Catalunya. ATEM - Anàlisi i Tecnologia d'Estructures i Materials, Universitat Politècnica de Catalunya. EGEO - Enginyeria Geomàtica, Chacón Flores, Rolando Antonio, Ramonell Cazador, Carlos, Puig i Polo, Càrol, and Mirambell Arrizabalaga, Enrique
- Abstract
A composite bridge located in the Metropolitan Area of Barcelona represents one of the sites for demonstrating the capabilities of digital twins on maintenance of built assets. Digital twins can be deemed to as digital living replica of the physical one that provides real time information throughout adequate connectivity (sensors, images, remote sensing) and provides automated visualization of the asset for decision-making purposes (performance indicators that are assessed regularly). This demonstrator is an 846 meters long composite bridge with plates and a concrete slab. The plates are tapered along a portion of its length. The bridge is horizontally curved with a bifurcation at its end. One of the challenges in this demonstrator is to reproduce realistically the “as built” shape of the plates using a terrestrial laser scanner for simulation purposes. The outcome of this specific side of the digital twinning (other sides also include many sensor- and image-based methods) is of great interest for maintenance managers. Understanding the real configuration of the asset represents an accurate starting point for subsequent modelling., All authors acknowledge the funding of ASHVIN, “Assistants for Healthy, Safe, and Productive Virtual Construction Design, Operation & Maintenance using a Digital Twin” an H2020 project under agreement 958161., Objectius de Desenvolupament Sostenible::9 - Indústria, Innovació i Infraestructura, Postprint (published version)
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- 2022
67. Ambient modal identification applied to a school building in Girona (Spain)
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Universitat Politècnica de Catalunya. Departament de Resistència de Materials i Estructures a l'Enginyeria, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. GIES - Geofísica i Enginyeria Sísmica, Universitat Politècnica de Catalunya. EGEO - Enginyeria Geomàtica, Pujades Beneit, Lluís, González Drigo, José Ramón, Lantada, Nieves, Blázquez Boya, Antoni, Jara Salvador, José Antonio, Universitat Politècnica de Catalunya. Departament de Resistència de Materials i Estructures a l'Enginyeria, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. GIES - Geofísica i Enginyeria Sísmica, Universitat Politècnica de Catalunya. EGEO - Enginyeria Geomàtica, Pujades Beneit, Lluís, González Drigo, José Ramón, Lantada, Nieves, Blázquez Boya, Antoni, and Jara Salvador, José Antonio
- Abstract
The main results of the operational modal analysis of a school building are shown. The building has a four-stories framed-reinforced-concrete structure and it was instrumented with 7 triaxial accelerometers, recording along eight days. Also, specific remote measurements were made with an interferometric radar. The purpose was: i) to monitor periods of activity-inactivity, ii) to identify modal frequencies; iii) to validate a numerical model of the structure and iv) to analyse the feasibility of the radar for remote operational modal analysis. This research allowed us: 1) to quantify clear variations in noise intensity, matching the school activities, 2) to identify the fundamental modes and natural frequencies, which were of 4.4 Hz and 5.4 Hz, in the longitudinal and transversal directions, respectively, 3) to observe slight variations of modal frequencies throughout the day, attributed to the loading/unloading of the building, and at night, attributed to variations in temperature; 4) to confirm the usefulness and suitability of frequency experimental measurements to improve the quality and reliability of building numerical models and, 5) to evaluate the potential of radar measurements for operational modal analysis; radar operates better in tall and flexible buildings, than in rigid ones., José Antonio Jara, of the “Institut Cartogràfic i Geològic de Catalunya”, ICGC, was responsible for the instrumentation of the building and for data collection and storage. The help of Meritxell Nicolau and Josep Soler, secretary and administrator of the “Institut Santa Eugènia” of Girona, Spain, is greatly recognized and acknowledged; they both made possible the accurate instrumentation of the building. Antoni Blázquez, from the Association of Structural Consultants (ACE), provided the plans and documentation of the building. This research has been partially funded by the Spanish Research Agency (AEI) of the Spanish Ministry of Science and Innovation (MICIN) through project with reference: PID2020-117374RB-I00/AEI/10.13039/501100011033, and by the European Regional Development Fund (ERDF) of the European Union (EU) through project with reference EFA158/16/POCRISC (INTERREG/POCTEFA. EU)., Postprint (published version)
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- 2022
68. ¿Cuánto grande es 'grande' en los movimientos de ladera? Encuesta sobre la idea de magnitud y su comunicación
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Universitat Politècnica de Catalunya. Doctorat en Enginyeria del Terreny, Universitat Politècnica de Catalunya. EGEO - Enginyeria Geomàtica, Janeras Casanova, Marc, Buxó, Pere, Marturiá Alavedra, Jordi, Barberà, Marcel, Ripoll, Jordi, Universitat Politècnica de Catalunya. Doctorat en Enginyeria del Terreny, Universitat Politècnica de Catalunya. EGEO - Enginyeria Geomàtica, Janeras Casanova, Marc, Buxó, Pere, Marturiá Alavedra, Jordi, Barberà, Marcel, and Ripoll, Jordi
- Abstract
La idea de magnitud de un fenómeno de ladera parece muy evidente, pero sometida a análisis no resulta tan simple. Además, carecemos de una escala de referencia para su valoración cualitativa. Esta indefinición en la magnitud se traslada al concepto de peligrosidad, lo cual dificulta la comunicación, incluso entre técnicos, y más aun con públicos más amplios, quienes resultan imprescindibles aliados para la implementación efectiva de estrategias de mitigación del riesgo. Esta preocupación por la comunicación de la idea de peligrosidad ha orientado en todo momento la elaboración de la guía técnica para la elaboración de Estudios de Identificación de Riesgos Geológicos (EIRG) por parte del ICGC. Esta figura resulta una pieza clave para la consideración de los riesgos geológicos en el urbanismo en Cataluña y hacer efectivo el mandato legislativo en la materia. A raíz de estos trabajos se ha desarrollado una escala de magnitud que pretende ser de la máxima simplicidad y claridad para lograr una comunicación adecuada del riesgo. En esta comunicación pretendemos realizar un test de viabilidad de la escala mediante una encuesta participativa a las personas participantes al simposio., Postprint (published version)
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- 2022
69. Spatial data infrastructure (SDI) for inventory rockfalls with fragmentation information
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Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. EGEO - Enginyeria Geomàtica, Núñez Andrés, María Amparo, Lantada, Nieves, Martínez llario, Jose, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. EGEO - Enginyeria Geomàtica, Núñez Andrés, María Amparo, Lantada, Nieves, and Martínez llario, Jose
- Abstract
The version of record of this article, first published in Natural Hazards is available online at Publisher's webside: https://doi.org/10.1007/s11069-022-05282-2, The fragmentation phenomenon has a significant effect on rockfall risk assessment. This information is difficult to obtain, but it is key to improving rockfall modelling. For this reason, the RockModels team has gathered data on the fragmentation of several natural events since 2014 that nowadays wants to share them with professionals, academics and stakeholders. The best way for the dissemination of this information is the use of standard or data specifications in order to be interoperable. A fragmentation rockfall database has been created using all the gathered information, according to the INSPIRE Natural Hazard Area Data Specification currently in force. However, new tables have had to be added, since this specification does not consider fragmentation data. There are currently 6000 records of geometries of source areas, envelopes, deposits and mostly individual blocks. A web mapping application, with an automatic function for coordinate reference system transformation, has been created to facilitate access to the spatial database information. All that was developed on open-source software such as OpenLayers JavaScript library, database (PostGre-PostGIS) and the map generating Web Map Service (GeoServer). As more data are collected, the database can be easily updated and the new information will be published. Moreover, to improve data interpretation, a future task is to incorporate 3D models on the web application. The existence of this public database will facilitate research and advance in knowledge of this kind of natural hazards., Peer Reviewed, Postprint (published version)
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- 2022
70. Capturing rockfall kinematic and fragmentation parameters using high-speed camera system
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Universitat Politècnica de Catalunya. Doctorat en Enginyeria del Terreny, Universitat Politècnica de Catalunya. Centre Específic de Recerca de Mètodes Numèrics en Ciències Aplicades i Enginyeria, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. EGEO - Enginyeria Geomàtica, Universitat Politècnica de Catalunya. EnGeoModels - Monitoring and Modelling in Engineering Geology, Prades Valls, Albert, Corominas Dulcet, Jordi, Lantada, Nieves, Matas Casado, Gerard, Núñez Andrés, María Amparo, Universitat Politècnica de Catalunya. Doctorat en Enginyeria del Terreny, Universitat Politècnica de Catalunya. Centre Específic de Recerca de Mètodes Numèrics en Ciències Aplicades i Enginyeria, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. EGEO - Enginyeria Geomàtica, Universitat Politècnica de Catalunya. EnGeoModels - Monitoring and Modelling in Engineering Geology, Prades Valls, Albert, Corominas Dulcet, Jordi, Lantada, Nieves, Matas Casado, Gerard, and Núñez Andrés, María Amparo
- Abstract
This paper presents a procedure for tracking rockfall trajectories and extracting kinematic parameters from both the impacts and the resultant fragments. A set of full scale rockfall experiments was performed in a quarry located in Vallirana, Barcelona (Spain). The study site was chosen due to the presence of a rigid discontinuity surface, inclined at 42° in the middle of the slope, whose configuration was expected to favor the breakage of the blocks. The trajectories of the blocks released and of the resultant fragments were recorded with three video cameras. A C++ program was specifically developed to track the 3D trajectory of blocks and fragments, and measure velocities before and after the impact. Two different modules were implemented, one for the blocks that break and one for those that do not. The trajectory of a non-fragmented block is obtained by comparing it to its 3D model. In this way, both the center of mass position and the orientation of the block are tracked. For fragmented blocks, the local coordinates of the fragments determined from the images are converted to terrain coordinates using the program we developed. A total of 16 blocks and 36 rock fragments after impact were tracked. The parameters obtained were georeferenced and linked to a common system of 3D terrestrial coordinates. The captured parameters allow obtaining the velocity distribution of fragments, the coefficient of restitution, and energy balance for the blocks that break. To our knowledge, this is the first attempt to capture kinematic parameters of rock fragments that result from the impact and breakage of rock blocks in full-scale tests. Although the analysis of the rockfall fragmentation phenomenon is beyond of this work, we have compared the performance of the fragmented and unbroken blocks. To this purpose, we have built 3D models of the rock fragments generated using images captured with a drone. The results indicate that blocks that fragment show higher rebound velocities an, Peer Reviewed, Postprint (published version)
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- 2022
71. Comparative analysis of a new assessment of the seismic risk of residential buildings of two districts of Barcelona
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Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Barcelona Supercomputing Center, Universitat Politècnica de Catalunya. EGEO - Enginyeria Geomàtica, Aguilar Meléndez, Armando, Pujades Beneit, Lluís, Barbat Barbat, Horia Alejandro, Monterrubio Velasco, Marisol, Puente Álvarez, Josep de la, Lantada, Nieves, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Barcelona Supercomputing Center, Universitat Politècnica de Catalunya. EGEO - Enginyeria Geomàtica, Aguilar Meléndez, Armando, Pujades Beneit, Lluís, Barbat Barbat, Horia Alejandro, Monterrubio Velasco, Marisol, Puente Álvarez, Josep de la, and Lantada, Nieves
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There are personal and institutional decisions that can increase the seismic resilience of the buildings in a city. However, some of these decisions are possible if we have basic knowledge of buildings’ seismic risk. The present document describes the main results of a detailed study of seismic vulnerability and seismic risk of residential buildings of Ciutat Vella (the ancient district of Barcelona) and Nou Barris (one of the newest districts of Barcelona). In this study, we assessed seismic risk according to the Vulnerability Index Method-Probabilistic named as VIM_P. Moreover, we analyzed the influence of basic buildings’ features in the final vulnerability and seismic risk values. For instance, we assessed the seismic vulnerability and the seismic risk of groups of buildings defined according to the number of stories of the buildings. Findings of this research reveal that the annual frequency of exceedance of the collapse damage state in Ciutat Vella buildings is, on average, 4.7 times higher than for the buildings in Nou Barris. Moreover, according to the Best vulnerability curve, 70.31% and 2.81% of Ciutat Vella and Nou Barris buildings, respectively, have an annual frequency of exceedance of the collapse damage state greater than 1 × 10–5., The present research has received partial funding from the European Union’s Horizon 2020 research 826 and innovation program (grant agreement Nº 823844, ChEESE CoE Project)., Peer Reviewed, Postprint (author's final draft)
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- 2022
72. Análisis de susceptibilidad de deslizamientos superficiales a escala regional: efecto de futuros cambios en el Val d’Aran (Pirineo Central)
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Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. Departament de Màquines i Motors Tèrmics, Universitat Politècnica de Catalunya. Doctorat en Enginyeria del Terreny, Universitat Politècnica de Catalunya. EnGeoModels - Monitoring and Modelling in Engineering Geology, Universitat Politècnica de Catalunya. CREMIT - Centre de Recerca de Motors i Instal·lacions Tèrmiques, Universitat Politècnica de Catalunya. EGEO - Enginyeria Geomàtica, Hurlimann Ziegler, Marcel, Medina Iglesias, Vicente César de, Puig i Polo, Càrol, Guo, Zizheng, Torra i Truncal, Ona, Gonzalez Díaz, Marta, Pinyol Guamis, Jordi, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. Departament de Màquines i Motors Tèrmics, Universitat Politècnica de Catalunya. Doctorat en Enginyeria del Terreny, Universitat Politècnica de Catalunya. EnGeoModels - Monitoring and Modelling in Engineering Geology, Universitat Politècnica de Catalunya. CREMIT - Centre de Recerca de Motors i Instal·lacions Tèrmiques, Universitat Politècnica de Catalunya. EGEO - Enginyeria Geomàtica, Hurlimann Ziegler, Marcel, Medina Iglesias, Vicente César de, Puig i Polo, Càrol, Guo, Zizheng, Torra i Truncal, Ona, Gonzalez Díaz, Marta, and Pinyol Guamis, Jordi
- Abstract
Los deslizamientos superficiales desencadenados por precipitaciones intensas pueden causar daños importantes en diferentes tipos de infraestructuras e incluso provocar pérdidas de vidas humanas. La ocurrencia de estos deslizamientos está directamente relacionada con futuros cambios (climáticos y de usos de suelo). Por ello es necesario disponer de herramientas para planificar el territorio y de esta manera contribuir a la reducción del riesgo asociado a estos procesos. En este estudio, se presenta un nuevo modelo de susceptibilidad llamado FSLAM basado en la teoría del talud infinito. El modelo calcula las presiones de agua en el suelo mediante dos modelos hidrológicos que incorporan la lluvia antecedente y la lluvia desencadenante. FSLAM es un modelo de código abierto que se ha implementado en un plugin de QGIS para su uso. El modelo FSLAM se ha aplicado y validado en cuatro áreas de centenares de kilómetros cuadrados del Pirineo (Andorra y Val d’Aran), del Pre-Pirineo (Berguedà) y de la Cordillera Prelitoral Catalana (Montseny). Se ha evaluado su eficiencia mediante el análisis ROC (Receiver Operating Characteristic) mostrando unos valores de precisión (accuracy) altos y satisfactorios a pesar de las incertidumbres de muchos parámetros de suelo. Mediante FSLAM se ha analizado la influencia de los efectos del cambio climático y de futuros cambios en los usos y cubiertas del suelo en la susceptibilidad a generar deslizamientos en la zona de la Val d’Aran. Los resultados indican que los cambios en las cubiertas del suelo, especialmente la transformación de prados y arbustos a bosques, aumenta la estabilidad global en la zona de estudio. Por el contrario, el aumento de precipitación diaria para un periodo de retorno de 100 años provoca una reducción de la estabilidad. Sin embargo, el efecto del cambio de las cubiertas del suelo es más importante que el cambio en las condiciones pluviométricas y, por ello, la estabilidad global en esta zona de estudio aumentará en el f, El presente estudio ha sido financiado por dos proyectos nacionales: SMuCPhy (BIA 2015-67500-R) y EROSLOP (PID2019-104266RB-I00/AEI/10.13039/501100011033)., Postprint (published version)
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- 2022
73. Comunicación de la geoinformación 3D mediante visores web y entornos inmersivos de realidad mixta en problemas de taludes y laderas
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Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. EGEO - Enginyeria Geomàtica, Buill Pozuelo, Felipe, Pedraza Royo, Oriol, Janeras, Marc, Gili Ripoll, José Antonio, Guinau, Marta, Roca Barberi, Joan Ramon, Ferré i Oltra, Anna, Struth, Lucía, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. EGEO - Enginyeria Geomàtica, Buill Pozuelo, Felipe, Pedraza Royo, Oriol, Janeras, Marc, Gili Ripoll, José Antonio, Guinau, Marta, Roca Barberi, Joan Ramon, Ferré i Oltra, Anna, and Struth, Lucía
- Abstract
La revolución experimentada por el uso creciente de la geoinformación 3D en la ingeniería geológica, gracias a los avances tecnológicos, que progresivamente han facilitado una disponibilidad de técnicas de adquisición de datos y de herramientas para su análisis. Junto a los avances experimentados en la disponibilidad de recursos de computación y almacenamiento en la nube, han impulsado la expansión de numerosas aplicaciones que permiten la difusión de la geoinformación 3D en la web. A pesar de estos avances científico-técnicos, es común ver los datos 3D simplificados en imágenes estáticas 2D, perdiendo parte su potencialidad comunicativa. El objetivo de esta comunicación es presentar el diseño y las funcionalidades de unos visores web 3D de código abierto como una herramienta de sencilla utilización con la que interactuar y visualizar los resultados. Así mismo, estamos ensayando las posibilidades de la realidad mixta como una experiencia plenamente inmersiva para lograr una mejor comunicación de la geoinformación 3D., Peer Reviewed, Postprint (published version)
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- 2022
74. Simulación de desprendimientos rocosos con fragmentación mediante RockGIS
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Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. Centre Específic de Recerca de Mètodes Numèrics en Ciències Aplicades i Enginyeria, Universitat Politècnica de Catalunya. EGEO - Enginyeria Geomàtica, Universitat Politècnica de Catalunya. EnGeoModels - Monitoring and Modelling in Engineering Geology, Matas Casado, Gerard, Lantada, Nieves, Corominas Dulcet, Jordi, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. Centre Específic de Recerca de Mètodes Numèrics en Ciències Aplicades i Enginyeria, Universitat Politècnica de Catalunya. EGEO - Enginyeria Geomàtica, Universitat Politècnica de Catalunya. EnGeoModels - Monitoring and Modelling in Engineering Geology, Matas Casado, Gerard, Lantada, Nieves, and Corominas Dulcet, Jordi
- Abstract
La fragmentación en desprendimientos rocosos es un fenómeno complejo y poco comprendido que afecta a la evaluación del peligro y del riesgo. Sólo algunos modelos de simulación de caídas de rocas lo consideran explícitamente. RockGIS es un programa de simulación numérica de desprendimientos rocosos que considera la fragmentación, empleando una aproximación puntual de la masa y un modelo de rebote mediante coeficientes de restitución. Su principal innovación es la implementación del modelo de fragmentación fractal (Rockfall Fractal Fragmentation Model, RFFM) para distribuir la masa al romper los bloques. Los parámetros del modelo de fragmentación se calculan según las condiciones cinemáticas de cada impacto para reproducir diferentes escenarios de fragmentación. El funcionamiento de RockGIS ha sido verificado y validado mediante ensayos a escala real y en diversos desprendimientos rocosos naturales. En esta contribución presentamos la evolución de RockGIS en los últimos años y su aplicación a diversos casos de estudio., Este estudio ha sido desarrollado en el marco del Proyecto de Investigación “Caracterización y modelado de desprendimientos de rocas” con el acrónimo RockModels, financiado por el Ministerio de Economía y Competitividad de España, y cofinanciado por la Agencia Estatal de Investigación (AEI) y el Fondo Europeo de Desarrollo Regional (FEDER) sobre el marco del Plan Estatal de Investigación Científico-Técnica e Innovación con código de referencia BIA2016-75668-P (AEI/FEDER,UE) y el proyecto de investigación “Avances en el análisis cuantitativo del riesgo de caída de rocas (QRA) incorporando desarrollos en geomática (GeoRisk)” con referencia PID2019-103974RB-I00, financiado por MCIN/AEI/10.13039/501100 011033, Ministerio de Ciencia e Innovación (MCIN) y la Agencia Estatal de Investigación (AEI)., Postprint (published version)
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- 2022
75. Medida de parámetros cinemáticos de bloques rocosos en un ensayo a escala real
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Universitat Politècnica de Catalunya. Doctorat en Enginyeria del Terreny, Universitat Politècnica de Catalunya. Centre Específic de Recerca de Mètodes Numèrics en Ciències Aplicades i Enginyeria, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. EGEO - Enginyeria Geomàtica, Universitat Politècnica de Catalunya. EnGeoModels - Monitoring and Modelling in Engineering Geology, Prades Valls, Albert, Corominas Dulcet, Jordi, Lantada, Nieves, Matas Casado, Gerard, Núñez Andrés, María Amparo, Universitat Politècnica de Catalunya. Doctorat en Enginyeria del Terreny, Universitat Politècnica de Catalunya. Centre Específic de Recerca de Mètodes Numèrics en Ciències Aplicades i Enginyeria, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. EGEO - Enginyeria Geomàtica, Universitat Politècnica de Catalunya. EnGeoModels - Monitoring and Modelling in Engineering Geology, Prades Valls, Albert, Corominas Dulcet, Jordi, Lantada, Nieves, Matas Casado, Gerard, and Núñez Andrés, María Amparo
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La evaluación del riesgo y el diseño de medidas de protección frente a desprendimientos de rocas requieren la predicción de las posibles trayectorias de los bloques susceptibles de desprenderse, así como la velocidad y la energía de llegada a las zonas que se deban proteger. Considerar la fragmentación introduce desafíos adicionales al modelado, tales como la energía disipada durante la fragmentación y la distribución de la energía restante entre los nuevos fragmentos. Para aclarar algunos de estos puntos se realizó un experimento a escala real, en el que se observaron las trayectorias de 16 bloques y de los fragmentos generados tras el impacto, empleando tres cámaras de video de alta velocidad. Para determinar la posición espacial de los bloques, hemos desarrollado un programa que permite calcular las velocidades, los momentos lineales, las energías en el instante anterior y posterior al impacto y, finalmente, los coeficientes de restitución asociados al impacto, Peer Reviewed, Objectius de Desenvolupament Sostenible::13 - Acció per al Clima, Objectius de Desenvolupament Sostenible::13 - Acció per al Clima::13.1 - Enfortir la resiliència i la capacitat d’adaptació als riscos relacionats amb el clima i els desastres naturals a tots els països, Postprint (published version)
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- 2022
76. Rockfalls: analysis of the block fragmentation through field experiments
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Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. Doctorat en Enginyeria del Terreny, Universitat Politècnica de Catalunya. Centre Específic de Recerca de Mètodes Numèrics en Ciències Aplicades i Enginyeria, Universitat Politècnica de Catalunya. EGEO - Enginyeria Geomàtica, Universitat Politècnica de Catalunya. EnGeoModels - Monitoring and Modelling in Engineering Geology, Gili Ripoll, José Antonio, Ruiz Carulla, Roger, Matas Casado, Gerard, Moya Sánchez, José, Prades Valls, Albert, Corominas Dulcet, Jordi, Lantada, Nieves, Núñez Andrés, María Amparo, Buill Pozuelo, Felipe, Puig i Polo, Càrol, Martínez Bofill, Joan, Salo Salgado, Lluis, Mavrouli, Olga Christina, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. Doctorat en Enginyeria del Terreny, Universitat Politècnica de Catalunya. Centre Específic de Recerca de Mètodes Numèrics en Ciències Aplicades i Enginyeria, Universitat Politècnica de Catalunya. EGEO - Enginyeria Geomàtica, Universitat Politècnica de Catalunya. EnGeoModels - Monitoring and Modelling in Engineering Geology, Gili Ripoll, José Antonio, Ruiz Carulla, Roger, Matas Casado, Gerard, Moya Sánchez, José, Prades Valls, Albert, Corominas Dulcet, Jordi, Lantada, Nieves, Núñez Andrés, María Amparo, Buill Pozuelo, Felipe, Puig i Polo, Càrol, Martínez Bofill, Joan, Salo Salgado, Lluis, and Mavrouli, Olga Christina
- Abstract
Fragmentation is a common feature of rockfall that exerts a strong control on the trajectories of the generated blocks, the impact energies, and the runout. In this paper, we present a set of four real-scale rockfall tests aimed at studying the fragmentation of the rocky blocks, from the global design of the field procedure to the data analysis and the main results. A total of 124 limestone, dacite, or granite blocks ranging between 0.2 and 5 m3 were dropped from different heights (8.5 to 23.6 m) onto four slopes with different shapes (single or double bench) and slope angles (42º to 71º). The characteristics of the blocks, in particular the size, surface texture and joint condition, were measured before the drops. The trajectories of the blocks and both the initial and the impact velocities were tracked and recorded by means of three high-speed video cameras. A total of 200 block-to-ground impacts have been studied. On average, 40% of the blocks broke upon impact on the slope or on the ground, making it necessary to measure the fragments. The initial and final sizes of the blocks/fragments were measured by hand with tape, though photogrammetric techniques (UAV and terrestrial) were also used for comparison purposes. The information gathered during the field tests provides a deep insight into the fragmentation processes. On the one hand, the high-resolution slow-motion videos help to describe when and how the block breakage takes place and the spatial distribution of the pieces. On the other hand, it is possible to compute the block trajectories, the velocities, and the energy losses using videogrammetry. The results include, for instance, a block average fragmentation of 54% and 14% for the limestone and granitoids, respectively; the systematic inventory of the size fragments, which may be used for fitting the power law distributions; and after each breakage, the total angle of aperture occupied by the fragments has been measured, with values in the range 25º–145º., The authors acknowledge the support of the Spanish Ministry of Economy and Competitiveness for the research projects RockRisk (BIA2013-42582-P), RockModels (BIA2016-75668-P, AEI, ERDF/FEDER, UE) and GeoRisk (PID2019-103974RB-I00/AEI/10.13039/501100011033). GeoRisk is funded by the Agencia Estatal de Investigación (AEI) on the framework of the Plan for Scientific-Technical Research and Innovation. The support of the Spanish Ministry of Education (grants to the second and third authors, codes FPU13/04252 and BES-2014-069795, respectively) and the BBVA Foundation (thirteenth author’s contract) is also appreciated. The collaboration of Canteras Hermanos Foj and Canteras Ponderosa S.A., Marc Janeras, and S. Moreno is greatly acknowledged. Finally, we thank two anonymous reviewers and the Editor who helped to improve the structure and content of the final version. Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature., Peer Reviewed, Postprint (published version)
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- 2022
77. Impacts of future climate and land cover changes on landslide susceptibility: regional scale modelling in the Val d’Aran region (Pyrenees, Spain)
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Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. Departament de Màquines i Motors Tèrmics, Universitat Politècnica de Catalunya. EnGeoModels - Monitoring and Modelling in Engineering Geology, Universitat Politècnica de Catalunya. EGEO - Enginyeria Geomàtica, Universitat Politècnica de Catalunya. CREMIT - Centre de Recerca de Motors i Instal·lacions Tèrmiques, Hurlimann Ziegler, Marcel, Guo, Zizheng, Puig i Polo, Càrol, Medina Iglesias, Vicente César de, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. Departament de Màquines i Motors Tèrmics, Universitat Politècnica de Catalunya. EnGeoModels - Monitoring and Modelling in Engineering Geology, Universitat Politècnica de Catalunya. EGEO - Enginyeria Geomàtica, Universitat Politècnica de Catalunya. CREMIT - Centre de Recerca de Motors i Instal·lacions Tèrmiques, Hurlimann Ziegler, Marcel, Guo, Zizheng, Puig i Polo, Càrol, and Medina Iglesias, Vicente César de
- Abstract
The final publication is available at Springer via http://dx.doi.org/10.1007/s10346-021-01775-6, It is widely accepted that future environmental changes will affect rainfall-induced shallow slides in high-mountain areas. In this study, the Val d’Aran region located in the Central Pyrenees was selected to analyze and quantify the impacts of land use and land cover (LULC) and climate changes on regional landslides susceptibility. We analyzed 26 climate models of the EURO-CORDEX database focussing on the future rainfall conditions. The IDRISI TerrSet software suite was used to create the future LULC maps. These two inputs were analyzed individually and in a combined way defining 20 different scenarios. All these scenarios were incorporated in a physically based stability model to compute landslides susceptibility maps. The results showed that both environmental conditions will considerably change in the future. The daily rainfall will increase between 14 and 26% assuming a return period of 100 years. This intensification of precipitation will produce an overall decrease of the stability condition in the study area. Regarding the LULC prediction, the forest area will significantly increase, while in particular grassland, but also shrubs decrease. As a consequence, the overall stability condition improves, because the root strength is higher in forest than in grassland and shrubs. When we analyzed the combined impacts, the results showed that the positive effect of LULC changes is larger than the negative influence of rainfall changes. Hence, when combining the two aspects in the future scenarios, the stability condition in the study area will improve., This study was funded by the national research project EROSLOP (PID2019-104266RBI00/AEI/10.13039/501100011033) of the Spain Government. Zizheng Guo acknowledges the financial support of China Scholarship Council for his research at UPC BarcelonaTECH, and Fundamental Research Funds for National Universities, China University of Geosciences (Wuhan)., Peer Reviewed, Postprint (author's final draft)
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- 2022
78. A Framework to Project Future Rainfall Scenarios: An Application to Shallow Landslide-Triggering Summer Rainfall in Wanzhou County China
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Universitat Politècnica de Catalunya. Departament de Màquines i Motors Tèrmics, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. CREMIT - Centre de Recerca de Motors i Instal·lacions Tèrmiques, Universitat Politècnica de Catalunya. EGEO - Enginyeria Geomàtica, Universitat Politècnica de Catalunya. EnGeoModels - Monitoring and Modelling in Engineering Geology, Ferrer Roman, Joaquin, Guo, Zizheng, Medina Iglesias, Vicente César de, Puig i Polo, Càrol, Hurlimann Ziegler, Marcel, Universitat Politècnica de Catalunya. Departament de Màquines i Motors Tèrmics, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. CREMIT - Centre de Recerca de Motors i Instal·lacions Tèrmiques, Universitat Politècnica de Catalunya. EGEO - Enginyeria Geomàtica, Universitat Politècnica de Catalunya. EnGeoModels - Monitoring and Modelling in Engineering Geology, Ferrer Roman, Joaquin, Guo, Zizheng, Medina Iglesias, Vicente César de, Puig i Polo, Càrol, and Hurlimann Ziegler, Marcel
- Abstract
Fatal landslides are a widespread geohazard that have affected millions of people and have claimed the lives of thousands around the globe. A change in climate has significantly increased the frequency and magnitude of rainfall, which affect the susceptibility of slopes to shallow landslides. This paper presents a methodological framework to assess the future changes in extreme and seasonal rainfall magnitudes with climate model projections. This framework was applied to project summer rainfall over Wanzhou County, China, using an ensemble of four regional climate models (RCMs) from the East Asian domain of the Coordinated Downscaling Experiment (CORDEX) under the Phase 5 Coupled Intercomparison Modeling Project (CMIP5). The results find that extreme daily rainfall was projected to decrease in the mid-21st century, with an uncertainty measured by a coefficient of variation between 5% and 25%. The mean seasonal rainfall is projected to increase in the mid-21st century up to a factor of 1.4, and up to a factor of 1.8 in the late-21st century. The variation in the mid21st century ranged from 10% to 35%, and from 30% to 50% in the late-21st century. This case study delivered a proof-of-concept for a methodological framework to derive shallow landslide-triggering rainfall scenarios under climate change conditions. The resulting spatially distributed climate change factors (CCFs) can be used to incorporate future rainfall scenarios in slope susceptibility models and climate impact assessments., Peer Reviewed, Objectius de Desenvolupament Sostenible::13 - Acció per al Clima, Postprint (updated version)
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- 2022
79. Procoagulant imbalance in premenopausal women with chronic migraine
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Ferroni, Patrizia, Barbanti, Piero, Aurilia, Cinzia, Egeo, Gabriella, Fofi, Luisa, La Farina, Francesca, Valente, Maria Giovanna, De Marchis, Maria Laura, Spila, Antonella, Palmirotta, Raffaele, Della-Morte, David, and Guadagni, Fiorella
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- 2017
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80. Rationale for use of onabotulinum toxin A (BOTOX) in chronic migraine
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Barbanti, P., Egeo, G., Fofi, L., Aurilia, C., and Piroso, S.
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- 2015
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81. Dopaminergic symptoms in migraine: A cross-sectional study on 1148 consecutive headache center-based patients
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Gabriella Egeo, Piero Barbanti, Fiorella Guadagni, Cinzia Aurilia, Patrizia Ferroni, and Luisa Fofi
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Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Sleepiness ,Vomiting ,Cross-sectional study ,Dopamine ,Migraine Disorders ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Center (algebra and category theory) ,Fatigue ,Aged ,030304 developmental biology ,0303 health sciences ,Mood Disorders ,business.industry ,Dopaminergic ,Nausea ,General Medicine ,Middle Aged ,medicine.disease ,Diuresis ,Cross-Sectional Studies ,Migraine ,Endophenotype ,Female ,Yawning ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Background Dopaminergic symptoms may be extremely pronounced in some migraine patients during the attack, representing a major source of disability. Objectives We aimed to carefully characterize the clinical picture of migraine patients with dopaminergic symptoms in a large patients’ population as a putative migraine endophenotype, allowing more precise disease management, treatment and outcome prediction. Methods We screened 1148 consecutive tertiary care episodic and chronic migraine patients with face-to-face interviews collecting thorough data on lifestyle, socio-demographic factors, and clinical migraine features. Results We identified 374 patients with migraine with dopaminergic symptoms (32.6%). The most frequent dopaminergic symptom was yawning followed by somnolence, nausea, vomiting, fatigue, mood changes and diuresis. Migraine patients with dopaminergic symptoms had longer attack duration (OR: 1.82; 95% CI: 1.41–2.36, p Conclusions Migraine patients with dopaminergic symptoms are characterized by a full-blown, more disabling migraine. Dopaminergic system modulation should be carefully considered in individuals with migraine with dopaminergic symptoms for both acute and preventative treatments in future ad hoc designed studies.
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- 2020
82. Machine learning approach to predict medication overuse in migraine patients
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Fabio Massimo Zanzotto, Antonella Spila, Piero Barbanti, Gabriella Egeo, Patrizia Ferroni, Alessandro Rullo, Raffaele Palmirotta, Noemi Scarpato, Luisa Fofi, and Fiorella Guadagni
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Artificial intelligence ,Decision support system ,BMI, body mass index ,SVM, Support Vector Machine ,Decision support systems ,Logistic regression ,Biochemistry ,0302 clinical medicine ,KELP, Kernel-based Learning Platform ,Structural Biology ,Medicine ,0303 health sciences ,NSAID, nonsteroidal anti-inflammatory drugs ,RO, Random Optimization ,Computer Science Applications ,MKL, Multiple Kernel Learning ,DBH 19-bp I/D polymorphism, Dopamine-Beta-Hydroxylase 19 bp insertion/deletion polymorphism ,ML, Machine Learning ,030220 oncology & carcinogenesis ,Medication overuse ,Research Article ,Biotechnology ,medicine.medical_specialty ,lcsh:Biotechnology ,MO, Medication Overuse ,ROC, Receiver operating characteristic ,Biophysics ,DSS, Decision Support System ,Discriminatory power ,AI, Artificial Intelligence ,03 medical and health sciences ,lcsh:TP248.13-248.65 ,Internal medicine ,LRs, likelihood ratios ,Machine learning ,ICT, Information and Communications Technology ,Genetics ,AUC, Area Under the Curve ,Migraine ,ComputingMethodologies_COMPUTERGRAPHICS ,030304 developmental biology ,PVI, Predictive Value Imputation ,business.industry ,medicine.disease ,CI, Confidence Interval ,SE, Standard Error ,Risk evaluation ,Weighting ,Support vector machine ,business - Abstract
Graphical abstract, Highlights • Medication overuse is related to chronicization and medication-overuse headache. • Prediction of medication overuse (MO) is a challenge in the management of migraine. • Machine learning and random optimization could help to estimate MO risk in migraine. • A customized decision support system was devised for migraine clinical management. • This approach may exploit significant patterns in data connoting causality., Machine learning (ML) is largely used to develop automatic predictors in migraine classification but automatic predictors for medication overuse (MO) in migraine are still in their infancy. Thus, to understand the benefits of ML in MO prediction, we explored an automated predictor to estimate MO risk in migraine. To achieve this objective, a study was designed to analyze the performance of a customized ML-based decision support system that combines support vector machines and Random Optimization (RO-MO). We used RO-MO to extract prognostic information from demographic, clinical and biochemical data. Using a dataset of 777 consecutive migraine patients we derived a set of predictors with discriminatory power for MO higher than that observed for baseline SVM. The best four were incorporated into the final RO-MO decision support system and risk evaluation on a five-level stratification was performed. ROC analysis resulted in a c-statistic of 0.83 with a sensitivity and specificity of 0.69 and 0.87, respectively, and an accuracy of 0.87 when MO was predicted by at least three RO-MO models. Logistic regression analysis confirmed that the derived RO-MO system could effectively predict MO with ORs of 5.7 and 21.0 for patients classified as probably (3 predictors positive), or definitely at risk of MO (4 predictors positive), respectively. In conclusion, a combination of ML and RO – taking into consideration clinical/biochemical features, drug exposure and lifestyle – might represent a valuable approach to MO prediction in migraine and holds the potential for improving model precision through weighting the relative importance of attributes.
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- 2020
83. Additional file 1 of Fremanezumab in the prevention of high-frequency episodic and chronic migraine: a 12-week, multicenter, real-life, cohort study (the FRIEND study)
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Barbanti, Piero, Egeo, Gabriella, Aurilia, Cinzia, d’Onofrio, Florindo, Albanese, Maria, Cetta, Ilaria, Di Fiore, Paola, Zucco, Maurizio, FilippiBonassi, Massimo, Bono, Francesco, Altamura, Claudia, Proietti, Stefania, Bonassi, Stefano, and Vernieri, Fabrizio
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Additional file 1: Table S1. Change in monthly migraine days (MMDs), monthly headache days (MHDs), monthly analgesic intake, Numerical Rating Scale (NRS) score, Headache Impact Test-6 (HIT-6) score, and Migraine Disability Assessment Scale (MIDAS) score from baseline to week 12. Table S2. Univariate analysis of independent determinant of ≥50% response in patients with high-frequency episodic migraine (HFEM) or chronic migraine (CM).
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- 2022
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84. Additional file 1 of Comparing the relative and absolute effect of erenumab: is a 50% response enough? Results from the ESTEEMen study
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Ornello, Raffaele, Baraldi, Carlo, Guerzoni, Simona, Lambru, Giorgio, Andreou, Anna P., Raffaelli, Bianca, Gendolla, Astrid, Barbanti, Piero, Aurilia, Cinzia, Egeo, Gabriella, Cevoli, Sabina, Favoni, Valentina, Vernieri, Fabrizio, Altamura, Claudia, Russo, Antonio, Silvestro, Marcello, Valle, Elisabetta Dalla, Mancioli, Andrea, Ranieri, Angelo, Alfieri, Gennaro, Latysheva, Nina, Filatova, Elena, Talbot, Jamie, Cheng, Shuli, Holle, Dagny, Scheffler, Armin, Ne����dal, Tom����, ��trn��ct��, Dana, ����pkov��, Jitka, Matou��ov��, Zuzana, Casalena, Alfonsina, Maddestra, Maurizio, Viola, Stefano, Affaitati, Giannapia, Giamberardino, Maria Adele, Pistoia, Francesca, Reuter, Uwe, and Sacco, Simona
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Data_FILES - Abstract
Additional file 1.
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- 2022
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85. Fremanezumab in the prevention of high-frequency episodic and chronic migraine: a 12-week, multicenter, real-life, cohort study (the FRIEND study)
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Piero Barbanti, Gabriella Egeo, Cinzia Aurilia, Florindo d'Onofrio, Maria Albanese, Ilaria Cetta, Paola Di Fiore, Maurizio Zucco, Massimo Filippi, Francesco Bono, Claudia Altamura, Stefania Proietti, Stefano Bonassi, and Fabrizio Vernieri
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Cohort Studies ,Treatment Outcome ,Double-Blind Method ,Migraine Disorders ,Headache ,Antibodies, Monoclonal ,Humans - Abstract
Background Fremanezumab has demonstrated to be effective, safe, and tolerated in the prevention of episodic or chronic migraine (CM) in randomized, placebo-controlled trials (RCTs). Real-life studies are needed to explore drug effects in unselected patients in routine circumstances and to provide higher generalizability results. This study explores the effectiveness, safety, and tolerability of fremanezumab in a real-life population of individuals affected by high-frequency episodic (HFEM: 8-14 days/month) or CM. Methods This is a 12-week multicenter, prospective, cohort, real-life study. We considered all consecutive patients affected by HFEM or CM visited at 9 Italian headache centers from 28/07/2020 to 11/11/2020. Eligible patients were given subcutaneous fremanezumab at the doses of 225 mg monthly or 675 mg quarterly, according to their preference. Primary study endpoints were the change in monthly migraine days (MMDs) in HFEM and monthly headache days (MHDs) in CM patients at weeks 9-12 compared to baseline. Secondary endpoints encompassed variation in monthly analgesic intake (MAI), Numerical Rating Scale (NRS), HIT-6 and MIDAS scores, and ≥50%, ≥75% and 100% responder rates at the same time intervals. Results 67 migraine patients had received ≥1 subcutaneous fremanezumab dose and were considered for safety analysis, while 53 patients completed 12 weeks of treatment and were included also in the effectiveness analysis. Fremanezumab was effective in both HFEM and CM, inducing at week 12 a significant reduction in MMDs (-4.6, p
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- 2021
86. Association of intronic variants of the KCNAB1 gene with lateral temporal epilepsy
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Busolin, Giorgia, Malacrida, Sandro, Bisulli, Francesca, Striano, Pasquale, Di Bonaventura, Carlo, Egeo, Gabriella, Pasini, Elena, Cianci, Vittoria, Ferlazzo, Edoardo, Bianchi, Amedeo, Coppola, Giangennaro, Elia, Maurizio, Mecarelli, Oriano, Gobbi, Giuseppe, Casellato, Susanna, Marchini, Marco, Binelli, Simona, Freri, Elena, Granata, Tiziana, Posar, Annio, Parmeggiani, Antonia, Vigliano, Piernanda, Boniver, Clementina, Aguglia, Umberto, Striano, Salvatore, Tinuper, Paolo, Giallonardo, A. Teresa, Michelucci, Roberto, and Nobile, Carlo
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- 2011
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87. Fremanezumab in the Prevention of High-Frequency Episodic and Chronic Migraine: A 12-Week, Multicenter, Real-Life, Cohort Study (The FRIEND Study).
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Barbanti, Piero, primary, Egeo, Gabriella, additional, Aurilia, Cinzia, additional, d'Onofrio, Florindo, additional, Albanese, Maria, additional, Cetta, Ilaria, additional, Fiore, Paola Di, additional, Zucco, Maurizio, additional, Filippi, Massimo, additional, Bono, Francesco, additional, Altamura, Claudia, additional, Proietti, Stefania, additional, Bonassi, Stefano, additional, and Vernieri, Fabrizio, additional
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- 2021
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88. Treatment of tension-type headache: from old myths to modern concepts
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Barbanti, P., Egeo, G., Aurilia, C., and Fofi, L.
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- 2014
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89. Maintenance of response and predictive factors of 1‐year GalcanezumAb treatment in real‐life migraine patients in Italy: The multicenter prospective cohort GARLIT study.
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Vernieri, Fabrizio, Brunelli, Nicoletta, Marcosano, Marilena, Aurilia, Cinzia, Egeo, Gabriella, Lovati, Carlo, Favoni, Valentina, Perrotta, Armando, Maestrini, Ilaria, Rao, Renata, d'Onofrio, Luigi, Finocchi, Cinzia, Aguggia, Marco, Bono, Francesco, Ranieri, Angelo, Albanese, Maria, Di Piero, Vittorio, Cevoli, Sabina, Altamura, Claudia, and Barbanti, Piero
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MIGRAINE ,BODY mass index ,COHORT analysis - Abstract
Background and Purpose: To evaluate the 1‐year effectiveness and tolerability of galcanezumab in real life and the prognostic indicators of persistent response. Methods: High‐frequency episodic migraine (HFEM) and chronic migraine (CM) patients treated with galcanezumab who completed a 1‐year observation were enrolled. The primary outcomes assessed during the 12 months (V1–V12) were the change in monthly migraine days (MMDs) from baseline and the response rates ≥50% in MMDs (MMD ≥50% RR). The secondary outcomes were changes in pain intensity (numerical rating scale [NRS]) and in monthly acute medication intake (MAMI). Results: We enrolled 191 patients (77.5% CM). Twenty‐three patients (12%) dropped out, two for nonserious adverse events. At least 40% of patients took add‐on standard preventives from baseline to V12. At V12, MMDs were reduced by 6.0 days in HFEM and by 11.9 days in CM patients (both p < 0.00001); NRS and MAMI were also decreased in both groups (p < 0.00001). One‐hundred eight (56.5%) patients presented MMD ≥50% RR for 9 cumulative months (interquartile range=8): we defined this value as the cutoff for a persistent response. Persistent responders were less likely to have a higher body mass index (BMI) (p = 0.007) but more frequently had a good response to triptans (p = 0.005) and MMD ≥50% RR at V1 (p < 0.0000001). Patients without a persistent response were on add‐on therapy for longer periods of time (p < 0.001). Conclusions: Galcanezumab was effective and well‐tolerated in the 1‐year term, with most patients presenting MMD ≥50% RR for at least 9 months. Triptan response, lower BMI, and MMD ≥50% RR in the first month emerged as predictive factors for a persistent response. [ABSTRACT FROM AUTHOR]
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- 2023
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90. Antioxidant and inflammatory polymorphism in patients with migraine with white matter hyperintensity (WMH)
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Fofi, Luisa, Ferroni, Patrizia, Palmirotta, Raffaele, Egeo, Gabriella, Aurilia, Cinzia, Valente, Maria Giovanna, De Marchis, Maria Laura, Ialongo, Cristiano, Pierallini, Alberto, Guadagni, Fiorella, and Barbanti, Piero
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- 2021
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91. Long-term (>48 weeks) safety and tolerability of erenumab in real-life
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Aurilia, Cinzia, Egeo, Gabriella, Fofi, Luisa, Cevoli, Sabina, Messina, Roberta, Salerno, Antonio, Torelli, Paola, Albanese, Maria, Carnevale, Antonio, Bono, Francesco, D'Amico, Domenico, Filippi, Massimo, Altamura, Claudia, Vernieri, Fabrizio, Colombo, Bruno, Frediani, Fabio, Mercuri, Bruno, D'Onofrio, Florindo, Grazzi, Licia, Aguggia, Marco, Favoni, Valentina, Finocchi, Cinzia, Fiore, Paola Di, Costa, Carlemina Maria, Brunelli, Nicoletta, Fallacara, Adriana, Bertuzzo, Davide, Zucco, Maurizio, Di Clemente, Laura, Trimboli, Michele, Pascarella, Angelo, Manzo, Lucia, and Barbanti, Piero
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- 2021
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92. Fremanezumab in the prevention of high-frequency episodic and chronic migraine: Friend (fremanezumab in real world study), the first Italian multicenter, prospective real-life study
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Fofi, Luisa, Egeo, Gabriella, Aurilia, Cinzia, Costa, Carmelina, Altamura, Claudia, Vernieri, Fabrizio, Albanese, Maria, D'Onofrio, Florindo, Di Clemente, Laura, Zucco, Maurizio, Di Fiore, Paola, Frediani, Fabio, Messina, Roberta, Colombo, Bruno, Filippi, Massimo, Bono, Francesco, Manzo, Lucia, Carnevale, Antonio, Barbanti, Piero, Proietti, Stefania, and Bonassi, Stefano
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- 2021
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93. Project for the establishment of the Italian migraine registry(I-GRAINE-NEW)
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Fofi, Luisa, Hollander, Lital, Aurilia, Cinzia, Egeo, Gabriella, Fiorentini, Giulia, Vanacore, Nicola, Bonassi, Stefano, and Tomino, Carlo
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- 2021
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94. Long term (48-weeks) effectiveness, safety and tolerability of erenumab in the prevention of high-frequency episodic and chronic migraine in real-world: The early 2 study
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Aurilia, Cinzia, Cevoli, Sabina, Egeo, Gabriella, Fofi, Luisa, Messina, Roberta, Salerno, Antonio, Torelli, Paola, Albanese, Maria, Carnevale, Antonio, Bono, Francesco, D'Amico, Domenico, Filippi, Massimo, Altamura, Claudia, Vernieri, Fabrizio, Colombo, Bruno, Frediani, Fabio, Mercuri, Bruno, D'Onofrio, Florindo, Grazzi, Licia, Aguggia, Marco, Favoni, Valentina, Finocchi, Cinzia, Di Fiore, Paola, Costa, Carlemina Maria, Brunelli, Nicoletta, Fallacara, Adriana, Bertuzzo, Davide, Zucco, Maurizio, Di Clemente, Laura, Trimboli, Michele, Pascarella, Angelo, Manzo, Lucia, and Barbanti, Piero
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- 2021
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95. Effectiveness, safety, and tolerability of galcanezumab in a real-life setting in patients with migraine in Italy (the GARLIT study)
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Valentina Favoni, Gabriella Egeo, Marco Aguggia, Claudia Altamura, Carmelina Maria Costa, Nicoletta Brunelli, Fabio Frediani, Paola Di Fiore, Adriana Fallacara, Luisa Fofi, Piero Barbanti, Davide Bertuzzo, Fabrizio Vernieri, Sabina Cevoli, Maria Albanese, Cinzia Aurilia, Giulia Pierangeli, Vernieri F., Altamura C., Aurilia C., Brunelli N., Egeo G., Fofi L., Costa C.M., Fallacara A., Favoni V., Pierangeli G., Aguggia M., Bertuzzo D., Albanese M., Di Fiore P., Frediani F., Cevoli S., and Barbanti P.
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Pediatrics ,medicine.medical_specialty ,Neurology ,business.industry ,Migraine Disorders ,MEDLINE ,Dermatology ,General Medicine ,medicine.disease ,Real life setting ,Antibodies, Monoclonal, Humanized ,Psychiatry and Mental health ,Tolerability ,Migraine ,Italy ,medicine ,Humans ,galcanezumab ,In patient ,migraine ,Neurology (clinical) ,Neurosurgery ,business ,Neuroradiology - Abstract
n.a.
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- 2020
96. When should we consider chronic patients as non-responders to monoclonal antibodies targeting the CGRP pathway?
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Cinzia Aurilia, Gabriella Egeo, Piero Barbanti, Claudia Altamura, Fabrizio Vernieri, Sabina Cevoli, Nicoletta Brunelli, and Luisa Fofi
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medicine.medical_specialty ,Neurology ,medicine.drug_class ,business.industry ,Calcitonin Gene-Related Peptide ,MEDLINE ,Antibodies, Monoclonal ,Calcitonin gene-related peptide ,Monoclonal antibody ,Non responders ,Text mining ,Antineoplastic Agents, Immunological ,Calcitonin Gene-Related Peptide Receptor Antagonists ,Immunology ,medicine ,Humans ,Neurology (clinical) ,business ,Neuroradiology - Published
- 2021
97. Clinical features, disease progression and use of healthcare resources in a large sample of 866 patients from 24 headache centers: A real-life perspective from the Italian chROnic migraiNe (IRON) project
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Piero, Barbanti, Luisa, Fofi, Licia, Grazzi, Fabrizio, Vernieri, Cecilia, Camarda, Paola, Torelli, Sabina, Cevoli, Antonio, Russo, Francesco, Bono, Cinzia, Finocchi, Renata, Rao, Stefano, Messina, Roberto, De Simone, Nicola, Vanacore, Stefano, Bonassi, Gabriella, Egeo, Barbanti, Piero, Fofi, Luisa, Grazzi, Licia, Vernieri, Fabrizio, Camarda, Cecilia, Torelli, Paola, Cevoli, Sabina, Russo, Antonio, Bono, Francesco, Finocchi, Cinzia, Rao, Renata, Messina, Stefano, De Simone, Roberto, Vanacore, Nicola, and Bonassi, Stefano
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Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Databases, Factual ,Migraine Disorders ,Disease ,registry ,State Medicine ,03 medical and health sciences ,0302 clinical medicine ,Chronic Migraine ,Surveys and Questionnaires ,Health care ,medicine ,Humans ,Mass Screening ,Medical history ,030212 general & internal medicine ,database ,Economic complexity ,business.industry ,Disease progression ,healthcare ,Middle Aged ,Patient Acceptance of Health Care ,Large sample ,Cross-Sectional Studies ,Neurology ,Italy ,Socioeconomic Factors ,economic burden ,Disease Progression ,Resource use ,Pain Clinics ,Female ,Settore MED/26 - Neurologia ,Neurology (clinical) ,chronic migraine ,business ,030217 neurology & neurosurgery - Abstract
Objective: To develop a dedicated Italian chronic migraine (CM) database (IRON project) to overcome disease misconceptions, improve clinical administration, reduce patients' burden, and rationalize economic resource allotment.Background: Proper CM management requires a comprehensive appraisal of its full clinical, social, and economic complexity.Methods: In this cross-sectional study, CM patients were screened in 24 certified headache centers with face-to-face interviews. Information on sociodemographic factors, medical history, characteristics of CM, and of prior episodic migraine (EM), and healthcare resource use was gathered using a semistructured web-based questionnaire.Results: A total of 866 CM patients were enrolled. CM started similar to 20 years after EM onset (age at EM onset 17.4 +/- 9.1 vs. age at CM onset 35.3 +/- 12.5 [mean +/- SD]). CM prophylaxis, used by 430/866 (49.6%) of the patients, was often ineffective, not tolerated, and prematurely discontinued. Medications and diagnostic workup, frequently inappropriate, were mostly subsidized by the Italian national health service. CM patients with >= 25 headache days/month revealed substantial clinical differences and heavier disability and economic burden compared with those with
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- 2021
98. Discontinuing Monoclonal Antibodies Targeting CGRP Pathway After One-Year Treatment: An Observational Longitudinal Cohort Study
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Vernieri, Fabrizio, primary, Brunelli, Nicoletta, additional, Messina, Roberta, additional, Costa, Carmelina Maria, additional, Colombo, Bruno, additional, Torelli, Paola, additional, Quintana, Simone, additional, Cevoli, Sabina, additional, Favoni, Valentina, additional, d'Onofrio, Florindo, additional, Egeo, Gabriella, additional, Rao, Renata, additional, Filippi, Massimo, additional, Barbanti, Piero, additional, and Altamura, Claudia, additional
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- 2021
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99. Dopamine-beta-hydroxylase 19-bp insertion/deletion polymorphism affects medication overuse in patients with chronic migraine
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David Della-Morte, Maria Laura De Marchis, Cristiano Ialongo, Cinzia Aurilia, Piero Barbanti, Patrizia Ferroni, Domenica Lovero, Gabriella Egeo, Luisa Fofi, Raffaele Palmirotta, and Fiorella Guadagni
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Adult ,Male ,medicine.medical_specialty ,19-bp insertion/deletion polymorphism ,Genotype ,Migraine Disorders ,Population ,Settore MED/09 ,Dopamine beta-Hydroxylase ,Dermatology ,03 medical and health sciences ,0302 clinical medicine ,Chronic Migraine ,Genetic ,INDEL Mutation ,Internal medicine ,medicine ,Dopamine-beta-hydroxylase ,Medication overuse ,Migraine ,Chronic Disease ,Female ,Genetic Predisposition to Disease ,Humans ,Middle Aged ,Prescription Drug Overuse ,030212 general & internal medicine ,Allele ,education ,Genotyping ,Genetic association ,education.field_of_study ,business.industry ,General Medicine ,medicine.disease ,Psychiatry and Mental health ,Endophenotype ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Dopamine-beta-hydroxylase (DBH) enzyme activity is modulated at the genetic level by the presence of several polymorphisms. Among these, the 19-bp insertion/deletion (I/D) polymorphism (rs72393728/rs141116007) was investigated in several genetic association studies for its correlation with the susceptibility to develop episodic migraine, but conflicting results were achieved. In the present study we analyzed this genetic variant in a carefully characterized population of migraineurs encompassing both episodic and chronic migraine (with and without medication overuse) with the aim to perform a replication study and verify any possible correlation with migraine endophenotypes. Genotyping of the DBH 19-bp I/D polymorphism was performed on 400 migraine patients and 204 healthy individuals. The associations between genotypic frequencies and the clinical and sociodemographic features of migraineurs were then investigated. The DBH 19-bp I/D polymorphism did not correlate with migraine susceptibility or most clinical variables, with the exception of a statistically significant correlation within the subgroup of patients affected by chronic migraine were the individuals carrying the deleted (D) allele were significantly more prone to abuse in analgesics. As a result of this finding, the DBH 19-bp I/D polymorphism does not influence migraine susceptibility, but it might contribute to the development of medication overuse in patient with chronic migraine.
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- 2019
100. Pharmacological Trials in Migraine: Itʼs Time to Reappraise Where the Headache Is and What the Pain Is Like
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Barbanti, Piero and Egeo, Gabriella
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- 2015
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