51. Effects of a 3-Week In-Hospital Body Weight Reduction Program on Cardiovascular Risk Factors, Muscle Performance, and Fatigue: A Retrospective Study in a Population of Obese Adults with or without Metabolic Syndrome
- Author
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Diana Caroli, Antonello E. Rigamonti, Silvano G. Cella, Sabrina Cicolini, Alessandro Sartorio, Massimo Scacchi, and Alessandra De Col
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Male ,cardiovascular risk factors ,obesity ,stair climbing test ,Basal (phylogenetics) ,0302 clinical medicine ,Weight loss ,030212 general & internal medicine ,Fatigue ,Aged, 80 and over ,education.field_of_study ,Nutrition and Dietetics ,Muscles ,Middle Aged ,Hospitals ,Weight Reduction Programs ,Cardiovascular Diseases ,Female ,medicine.symptom ,lcsh:Nutrition. Foods and food supply ,Adult ,medicine.medical_specialty ,Adolescent ,Population ,Diastole ,body mass index ,030209 endocrinology & metabolism ,lcsh:TX341-641 ,Article ,metabolic syndrome ,Young Adult ,03 medical and health sciences ,body weight reduction program ,Internal medicine ,Weight Loss ,medicine ,Humans ,education ,Aged ,Retrospective Studies ,business.industry ,Cholesterol, HDL ,Retrospective cohort study ,medicine.disease ,Obesity ,Heart Disease Risk Factors ,fatigue severity score ,Metabolic syndrome ,business ,Body mass index ,Food Science - Abstract
Background. In clinical practice, there is the diffuse conviction that obese subjects with metabolic syndrome may be more difficult to treat. Objectives and Methods. The aim of the present study was that to investigate the effectiveness of a 3-week in-hospital body weight reduction program (BWRP) in a large population of obese subjects with and without metabolic syndrome (n = 1922, 222 men and 1700 women, age range 18&ndash, 83 yr). Outcomes such as body mass index (BMI), total (TOT) and HDL cholesterol, systolic and diastolic blood pressures (SBP and DBP, respectively), coronary heart disease (CHD) score, fatigue severity score (FSS), and stair climbing test (SCT) time were evaluated before and after the intervention (&Delta, ). A sex-, BMI-, and age-related stratification of the obese population with or without metabolic syndrome was applied. Results. When compared to obese subjects without metabolic syndrome, at the basal conditions, obese subjects had a poorer cardiometabolic profile, as demonstrated by higher triglycerides, TOT-cholesterol, DBP, SBP, and CHD score, and a more compromised muscle performance (evaluated by SCT), associated with more perception of fatigue (measured by FSS). Nevertheless, obese subjects with metabolic syndrome obtained more benefits from BWRP than those without metabolic syndrome for some outcomes (i.e., &Delta, TOT-cholesterol, &Delta, SBP, and &Delta, CHD score). Despite these differences, the BWRP-induced weight loss was similar between the two groups (i.e., &Delta, BMI) as well as the gain of muscle performance (i.e., &Delta, SCT) and the reduction of fatigue (i.e., &Delta, FSS). Interestingly, the potentially deleterious fall in HDL-cholesterol levels after BWRP was less evident in obese subjects with metabolic syndrome than those without metabolic syndrome. When pooling all data, the &Delta, CHD score was associated with age, sex, and metabolic syndrome. The remaining outcomes, such as &Delta, BMI, &Delta, FSS, and &Delta, SCT time, were associated with sex and age but not with metabolic syndrome. Finally, &Delta, BMI was positively correlated with &Delta, CHD score, &Delta, SCT time in both obese subjects without metabolic syndrome and obese subjects with metabolic syndrome. Conclusions. When comparing obese subjects undergoing a BWRP, metabolic syndrome is not a negative predictive factor affecting the effectiveness of this intervention in terms of weight loss, muscle performance, and psychological well-being.
- Published
- 2020