183 results on '"Dario Arnaldi"'
Search Results
52. Patients with amnesic mild cognitive impairment due to Alzheimer's disease and with epileptiform‐like signatures showed abnormal cortical sources of resting state delta EEG rhythms: An EEG study
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Federico Tucci, Claudio Babiloni, Giuseppe Noce, Carlo Di Bonaventura, Roberta Lizio, Ivan Lorenzo, Andrea Soricelli, Raffaele Ferri, Flavio Nobili, Francesco Famà, Dario Arnaldi, Eleonora Palma, Pierangelo Cifelli, Moira Marizzoni, Fabrizio Stocchi, Giovanni Frisoni, and Claudio Del Percio
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Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Neurology (clinical) ,Geriatrics and Gerontology - Published
- 2021
53. Case 8: Multiple System Atrophy with DAT SPECT and [18F]FDG PET
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Dario Arnaldi and Silvia Morbelli
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Atrophy ,business.industry ,medicine ,Dat spect ,medicine.disease ,Nuclear medicine ,business ,18f fdg pet - Published
- 2021
54. Twenty-four-hour blood pressure profile in idiopathic REM sleep behavior disorder
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Natascia Ghiotto, Valter Rustioni, Maurizio Versino, Gianluca Rustioni, Ivana Sartori, Raffaele Manni, Michele Terzaghi, Dario Arnaldi, and Laura Pilati
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medicine.medical_specialty ,Ambulatory blood pressure ,REM sleep behavior disorder ,Diastole ,Age and sex ,dipping status ,ABPM ,blood pressure ,circadian BP profile ,parasomnias ,Blood Pressure Monitoring ,Physiology (medical) ,Internal medicine ,Ambulatory ,medicine ,Humans ,Prospective Studies ,Aged ,Blood Pressure ,Blood Pressure Monitoring, Ambulatory ,Follow-Up Studies ,Middle Aged ,REM Sleep Behavior Disorder ,Circadian blood pressure ,business.industry ,Control subjects ,Blood pressure ,Cohort ,Cardiology ,Sleep behavior ,Neurology (clinical) ,business - Abstract
Study Objectives To determine whether autonomic dysfunction in idiopathic REM sleep behavior disorder (iRBD) affects circadian blood pressure (BP) profile. Methods Twenty-one iRBD (mean age 68.8 ± 6.4, mean age at onset 62.2 ± 9.3), 21 drug-free de novo Parkinson’s disease (PD) and 21 control participants (HCs), comparable for age and sex, underwent 24-h ambulatory BP monitoring. A prospective follow-up study was performed to evaluate the occurrence of neurodegenerative disorders in the iRBD cohort. Results In the iRBD group, nighttime systolic BP (SBP) was higher (124.0 ± 20.0, p = .026), nocturnal BP decrease lower (4.0 ± 8.7% for SBP and 8.7 ± 8.0% for diastolic BP [DBP], p = .001), and nondipping status more frequent (71.4% for SBP and 52.4% for DBP; p = .001 and p = .01, respectively) than in the HCs. Reverse dipping of SBP was found in 23.8% (p = .048) of the iRBD participants. Nondipping status was not associated with differences in gender, age, disease duration, age at disease onset, UPDRS score, presence of antihypertensive therapy, or polysomnographic measures. Patients with PD showed daytime and nighttime BP profiles comparable to those observed in iRBD. A subgroup analysis considering only the participants without antihypertensive therapy (12 iRBD, 12 PD) showed results superimposable on those of the whole iRBD and PD groups. Longitudinal follow-up (mean 5.1 ± 1.9 years) showed no differences in BP profile at baseline between converters (n = 6) and nonconverters. Conclusions Twenty-four-hour BP control was impaired in iRBD. This impairment, similar to patterns observed in de novo PD, consisted of reduced amplitude of nocturnal dipping and increased frequency of nondipping status. These findings could have implications for cardiovascular morbidity and mortality in iRBD.
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- 2021
55. Multimodal approach in the pre-surgical evaluation of focal epilepsy surgery candidates: how far are we from a non-invasive ESI-based 'sourcectomy'?
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Massimo Cossu, Giulia Nobile, Margherita Mancardi, Lino Nobili, Dario Arnaldi, Silvia Morbelli, Francesca Gianno, Ivana Sartori, Mattia Pacetti, Matteo Cataldi, Alessandro Consales, and Domenico Tortora
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focal epilepsy ,Male ,medicine.medical_specialty ,Drug Resistant Epilepsy ,Adolescent ,Electroencephalography ,Epilepsy ,Neuroimaging ,Functional neuroimaging ,ESI ,Medicine ,Humans ,Epilepsy surgery ,FCD ,HdEEG ,arterial spin labelling ,epilepsy surgery ,multimodal ,medicine.diagnostic_test ,business.industry ,Multimodal therapy ,General Medicine ,Cortical dysplasia ,medicine.disease ,Magnetic Resonance Imaging ,Malformations of Cortical Development ,Treatment Outcome ,Neurology ,Pharmaceutical Preparations ,Positron emission tomography ,Malformations of Cortical Development, Group I ,Neurology (clinical) ,Radiology ,Epilepsies, Partial ,business - Abstract
The management of drug-resistant patients with focal epilepsy is often challenging. Surgery is recognised as a useful and effective treatment option. The identification of the epileptogenic zone relies on the integration of clinical, neurophysiological, and neuroimaging findings. The role of non-invasive functional neuroimaging techniques has been reported to add diagnostic accuracy to first-line evaluations, avoiding invasive presurgical examinations in selected cases. In this view, we report the case of a 16-year-old male suffering from drug-resistant focal epilepsy with episodes rarely evolving to a bilateral tonic-clonic seizure. Conventional 1.5T and 3T MRI were considered uninformative. Based on electro-clinical data, focal cortical dysplasia was suspected. The epileptogenic zone was identified with the integration of further non-invasive functional neuroimaging techniques ([18F]-fluorodeoxyglucose positron emission tomography and arterial spin labelling), where electrical source imaging played the main role. All techniques pointed towards a cortical region, where a 7T brain MRI identified a signal alteration consistent with focal cortical dysplasia. A tailored resection of the lesion located in the inferior frontal sulcus was performed, guided by intraoperative electrocorticography (strip and depth electrodes). Postoperative seizure freedom was achieved. The histopathology confirmed the suspicion of focal cortical dysplasia type IIa. With this case report, we highlight the importance of a multimodal approach in the presurgical evaluation of candidates for epilepsy surgery, which, in selected cases, may allow invasive procedures, such as stereo-EEG, to be avoided in the investigation of the epileptogenic zone. Moreover, we underline the pivotal role of EEG source imaging, especially when focal cortical dysplasia is suspected.
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- 2021
56. Dopaminergic and Serotonergic Degeneration and Cortical [
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Beatrice, Orso, Dario, Arnaldi, Nicola, Girtler, Andrea, Brugnolo, Elisa, Doglione, Pietro, Mattioli, Erica, Biassoni, Roberto, Fancellu, Federico, Massa, Matteo, Bauckneht, Silvia, Chiola, Silvia, Morbelli, Flavio, Nobili, and Matteo, Pardini
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Tomography, Emission-Computed, Single-Photon ,Dopamine Plasma Membrane Transport Proteins ,Dopamine ,Positron-Emission Tomography ,Humans ,Parkinson Disease - Abstract
Degeneration of the nigrostriatal dopaminergic (DA) and the raphe-thalamic serotonergic (SE) systems is among the earliest changes observed in Parkinson's disease (PD). The consequences of those changes on brain metabolism, especially regarding their impact on the cortex, are poorly understood.Using multi-tracer molecular imaging, we assessed in a cohort of drug-naive PD patients the association between cortical metabolism and DA and SE system deafferentation of either striatum or thalamus, and we explored whether this association was mediated by either striatum or thalamus metabolism.We recruited 96 drug-naive PD patients (aged 71.9 ± 7.5 years) who underwent [We found that [These data suggest that the impact of deep gray matter monoaminergic deafferentation on cortical function is mediated by striatal and thalamic metabolism in drug-naive PD. © 2021 International Parkinson and Movement Disorder Society.
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- 2021
57. Head-to-Head Comparison among Semi-Quantification Tools of Brain FDG-PET to Aid the Diagnosis of Prodromal Alzheimer’s Disease1
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Gianmario Sambuceti, Cathrine Jonsson, Patrizia Mecocci, Mira Didic, Robert Perneczky, Matteo Pardini, Bart N.M. van Berckel, Dario Arnaldi, Federico Massa, Giovanni B. Frisoni, Matteo Grazzini, Marco Pagani, Rik Ossenkoppele, Matteo Bauckneht, Alexander Drzezga, Eric Guedj, Fabrizio De Carli, Andrea Brugnolo, Samantha Galluzzi, Massimo E. Dottorini, S. Morbelli, Flavio Nobili, and Andrea Chincarini
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0301 basic medicine ,Receiver operating characteristic ,business.industry ,General Neuroscience ,Youden's J statistic ,General Medicine ,Statistical parametric mapping ,computer.software_genre ,Support vector machine ,03 medical and health sciences ,Psychiatry and Mental health ,Clinical Psychology ,030104 developmental biology ,0302 clinical medicine ,Neuroimaging ,Region of interest ,Voxel ,Medicine ,Geriatrics and Gerontology ,Verbal memory ,business ,Nuclear medicine ,computer ,030217 neurology & neurosurgery - Abstract
Background: Several automatic tools have been implemented for semi-quantitative assessment of brain [ 18 ]F-FDG-PET. Objective: We aimed to head-to-head compare the diagnostic performance among three statistical parametric mapping (SPM)-based approaches, another voxel-based tool (i.e., PALZ), and a volumetric region of interest (VROI-SVM)-based approach, in distinguishing patients with prodromal Alzheimer's disease (pAD) from controls. Methods: Sixty-two pAD patients (MMSE score = 27.0±1.6) and one hundred-nine healthy subjects (CTR) (MMSE score = 29.2±1.2) were enrolled in five centers of the European Alzheimer's Disease Consortium. The three SPM-based methods, based on different rationales, included 1) a cluster identified through the correlation analysis between [ 18 ]F-FDG-PET and a verbal memory test (VROI-1), 2) a VROI derived from the comparison between pAD and CTR (VROI-2), and 3) visual analysis of individual maps obtained by the comparison between each subject and CTR (SPM-Maps). The VROI-SVM approach was based on 6 VROI plus 6 VROI asymmetry values derived from the pAD versus CTR comparison thanks to support vector machine (SVM). Results: The areas under the ROC curves between pAD and CTR were 0.84 for VROI-1, 0.83 for VROI-2, 0.79 for SPM maps, 0.87 for PALZ, and 0.95 for VROI-SVM. Pairwise comparisons of Youden index did not show statistically significant differences in diagnostic performance between VROI-1, VROI-2, SPM-Maps, and PALZ score whereas VROI-SVM performed significantly (p < 0.005) better than any of the other methods. Conclusion: The study confirms the good accuracy of [ 18 ]F-FDG-PET in discriminating healthy subjects from pAD and highlights that a non-linear, automatic VROI classifier based on SVM performs better than the voxel-based methods.
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- 2019
58. Phase and amplitude correlations change with disease progression in idiopathic Rapid eye-movement sleep behavior disorder patients
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Silvia Morbelli, Nicola Girtler, Beatrice Orso, Pietro Mattioli, Flavio Nobili, Laura Giorgetti, Dario Arnaldi, Andrea Canessa, Gabriele Arnulfo, Monica Roascio, Rosella Trò, and Francesco Famà
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Synucleinopathies ,0303 health sciences ,medicine.medical_specialty ,Mini–Mental State Examination ,medicine.diagnostic_test ,Dementia with Lewy bodies ,business.industry ,Neuropsychology ,Rapid eye movement sleep ,Alpha (ethology) ,Cognition ,Audiology ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Cognitive decline ,business ,030217 neurology & neurosurgery ,030304 developmental biology - Abstract
Cognitive decline is a common trait of neurodegenerative diseases of central nervous system and one of the major risk factors associated with faster phenoconversion from prodromal stages. In the transition to full-blown clinical syndromes, increased phase synchronization in the theta, alpha or beta EEG rhythms is thought to reflect the activation of compensatory mechanisms that may counterbalance the cognitive decline of patients affected by Mild Cognitive Impairment (MCI). Patients suffering from idiopathic Rapid eye-movement sleep Behavior Disorder (iRBD) have high risk of developing Parkinson Disease (PD) or Dementia with Lewy Bodies (DLB) and cognitive impairment is among the strongest risk factors together with motor symptoms. Here we wanted to investigate whether altered phase synchronization and amplitude couplings of the brain oscillations could be linked to the balancing of cognitive decline in a longitudinal cohort (N=18) of iRBD patients. We measured high-density Electroencephalographic (HD-EEG) activity at baseline and follow-up and quantified power distribution, orthogonalized amplitude correlation and weighted phase lag index. Despite the overt neurodegenerative progression (three patients converted to PD and one to DLB), cognitive decline was not evident from Mini Mental State Examination (MMSE) or neuropsychological tests. On the other hand, alpha phase synchronization and delta amplitude correlations were significantly different at follow-up compared to baseline. In particular, alpha synchrony was enhanced while delta amplitude coupling was reduced. Those differences were more pronounced among central-posterior channels while frontal channels showed a reduced number of significant edges with respect to surrogates. Both large-scale amplitude and phase coupling significantly correlated with cognitive or neuropsychological scores but not with sleep quality indices. Altogether, these results suggest that increased alpha phase-synchronization and reduced delta amplitude correlation may be considered as electrophysiological signs of an active compensatory mechanism of the cognitive impairment in RDB patients. Large-scale functional modifications could thus be used as significant biomarker in the characterization of prodromal stages of PD.Statement of SignificanceCognitive impairment and RBD emerge much earlier than the better-known motor symptoms distinctive of synucleinopathies. An improved investigation of RBD may constitute an important biomarker for an early diagnosis of the actual neurodegenerative diseases. For the first time, this preliminary study aims to quantify the large-scale network couplings as electrophysiological manifestation of the compensatory mechanism to the cognitive impairment in a longitudinal study of idiopathic RBD patients. Unfortunately, the small number of the subjects limits the generalizability of our observations, but this is only preliminary works in a larger project that aims to investigate advanced electrophysiological markers for an early diagnosis of the synucleinopathies.
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- 2021
59. Hyperconnectivity in dementia is early and focal and wanes with progression
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Filomena Barbone, Annachiara Cagnin, Laura Bonanni, Claudia Carrarini, Alessandro Padovani, Ftd Italian study group-SINDEM, Claudio Babiloni, Mirella Russo, Barbara Borroni, Dario Arnaldi, Flavio Nobili, Marco Onofrj, Nicola Walter Falasca, Laura Ferri, Alberto Benussi, Raffaella Franciotti, Giacomo Koch, and Davide V. Moretti
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Male ,medicine.medical_specialty ,Cognitive Neuroscience ,Prodromal Symptoms ,Electroencephalography ,frontotemporal dementia ,Functional Laterality ,NO ,Cohort Studies ,Functional networks ,Cellular and Molecular Neuroscience ,Alzheimer Disease ,Frontal regions ,Internal medicine ,mental disorders ,Humans ,Medicine ,Dementia ,Longitudinal Studies ,EEG ,Pathological ,Aged ,Aged, 80 and over ,Alzheimer’s disease, EEG, frontotemporal dementia, hyperconnectivity ,medicine.diagnostic_test ,business.industry ,hyperconnectivity ,Prodromal Stage ,Alzheimer's disease ,Alzheimer’s disease ,Hyperconnectivity ,Middle Aged ,medicine.disease ,Electrophysiological Phenomena ,Frontal Lobe ,Disease Progression ,Cardiology ,Female ,Atrophy ,Nerve Net ,business ,Frontotemporal dementia - Abstract
We investigated in a longitudinal multicenter cohort study functional cortical connectivity changes along the course of frontotemporal dementia (FTD) and Alzheimer’s disease (AD) from the prodromal stage of the diseases. Electroencephalography (EEG) was recorded in 18 FTD and 18 AD patients at the prodromal stage of dementia, at dementia onset, and 3 years after dementia onset. Twenty healthy controls (HC) underwent EEG recordings at the same time interval as the patients. Mutual information (MI) analysis measured the strength of functional network connectivity. FTD and AD patients showed greater MI at the prodromal stage of dementia (FTD vs. HC P = 2 × 10−8; AD vs. HC P = 4 × 10–3). Local connectivity was higher in left and right frontal areas of FTD (P = 7 × 10−5 and 0.03) and in left and right posterior areas in AD (P = 3 × 10−5 and 5 × 10−5) versus HC. We showed cortical hyperconnectivity at the prodromal stage of dementia in areas involved in the specific pathological process of FTD (frontal regions) and AD (posterior regions). Hyperconnectivity disappeared during follow-up, thus suggesting that it is an early electrophysiological feature of dementia, potentially useful to identify prodromal FTD and AD.
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- 2021
60. Biomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder
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Rebekah L.S. Summers, Michele T.M. Hu, Petr Dusek, Mitchell G. Miglis, Jennifer Zitser, Charles H. Adler, Kaylena A. Ehgoetz Martens, Alex Iranzo, Jun Liu, Claudio Liguori, Christine Lo, Annette Janzen, Klaus L. Leenders, Dallah Yoo, Dario Arnaldi, Giuseppe Plazzi, Michal Rolinski, Bradley F. Boeve, Elena Antelmi, Irene Dall'Antonia, Monica Puligheddu, Nico J. Diederich, Luca Baldelli, Wiebke Hermann, Jan Rusz, Raffaele Ferri, Jee Young Lee, Matteo Cesari, Simon J.G. Lewis, Ambra Stefani, Anastasia Kuzkina, Ziv Gan-Or, Federica Provini, Birgit Högl, Kathrin Doppler, Jiri Nepozitek, Jean Gagnon, Wolfgang H. Oertel, Miglis M.G., Adler C.H., Antelmi E., Arnaldi D., Baldelli L., Boeve B.F., Cesari M., Dall'Antonia I., Diederich N.J., Doppler K., Dusek P., Ferri R., Gagnon J.-F., Gan-Or Z., Hermann W., Hogl B., Hu M.T., Iranzo A., Janzen A., Kuzkina A., Lee J.-Y., Leenders K.L., Lewis S.J.G., Liguori C., Liu J., Lo C., Ehgoetz Martens K.A., Nepozitek J., Plazzi G., Provini F., Puligheddu M., Rolinski M., Rusz J., Stefani A., Summers R.L.S., Yoo D., Zitser J., and Oertel W.H.
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diagnosis [REM Sleep Behavior Disorder] ,Synucleinopathies ,α-synucleinopathies ,Prognosi ,diagnosis [Synucleinopathies] ,REM Sleep Behavior Disorder ,Disease ,Bioinformatics ,DEPOSITS ,subtype prediction ,chemistry.chemical_compound ,Atrophy ,disease progression ,PARKINSONS-DISEASE ,Rapid eye movement sleep behaviour disorder ,complications [REM Sleep Behavior Disorder] ,medicine ,Disease Progression ,Humans ,Prognosis ,alpha-Synuclein ,Biomarkers ,ddc:610 ,Synucleinopathie ,Cognitive decline ,α synucleinopathy ,Alpha-synuclein ,IDENTIFICATION ,Dementia with Lewy bodies ,business.industry ,Disease progression ,NEURODEGENERATION ,biomarkers ,ASSOCIATION ,etiology [Synucleinopathies] ,medicine.disease ,rapid-eye-movement sleep behaviour disorder (RBD) ,ATONIA INDEX ,THRESHOLDS ,chemistry ,REM-SLEEP ,MUSCLE-ACTIVITY ,TO-NIGHT VARIABILITY ,Neurology (clinical) ,business ,Human - Abstract
Patients with isolated rapid-eye-movement sleep behaviour disorder (RBD) are commonly regarded as being in the early stages of a progressive neurodegenerative disease involving alpha-synuclein pathology, such as Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy. Abnormal alpha-synuclein deposition occurs early in the neurodegenerative process across the central and peripheral nervous systems and might precede the appearance of motor symptoms and cognitive decline by several decades. These findings provide the rationale to develop reliable biomarkers that can better predict conversion to clinically manifest alpha-synucleinopathies. In addition, biomarkers of disease progression will be essential to monitor treatment response once disease-modifying therapies become available, and biomarkers of disease subtype will be essential to enable prediction of which subtype of alpha-synucleinopathy patients with isolated RBD might develop.
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- 2021
61. Pre-sleep arousal and sleep quality during the COVID-19 lockdown in Italy
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Maurizio Gorgoni, Laura Palagini, Lino Nobili, Giulio Alessandro Bonetti, Dario Arnaldi, Francesco Fanfulla, Luigi Ferini-Strambi, Giuseppe Plazzi, Enrica Bonanni, Maria R. Bonsignore, Anastasia Mangiaruga, Raffaele Ferri, C. Castronovo, Sergio Garbarino, Michelangelo Maestri, Alessandro Silvani, Serena Scarpelli, Valentina Alfonsi, Monica Puligheddu, Raffaele Manni, Biancamaria Guarnieri, Claudio Vicini, Luigi De Gennaro, Gorgoni M., Scarpelli S., Mangiaruga A., Alfonsi V., Bonsignore M.R., Fanfulla F., Ferini-Strambi L., Nobili L., Plazzi G., De Gennaro L., Arnaldi D., Bonanni E., Bonetti G.A., Castronovo C., Maestri M., Garbarino S., Guarnieri B., Manni R., Palagini L., Puligheddu M., Ferri R., Silvani A., and Vicini C.
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stress depression ,COVID-19 pandemic ,Depression ,Pre-sleep arousal ,Sleep quality ,Stress ,Coronavirus disease 2019 (COVID-19) ,Pre sleep arousal ,Stre ,Socio-culturale ,Settore MED/10 - Malattie Dell'Apparato Respiratorio ,Arousal ,Communicable Disease Control ,Humans ,Pandemics ,SARS-CoV-2 ,Sleep ,Sleep Quality ,Surveys and Questionnaires ,COVID-19 ,Sleep Initiation and Maintenance Disorders ,Insomnia ,medicine ,Surveys and Questionnaire ,Depression (differential diagnoses) ,Pandemic ,business.industry ,Cognition ,General Medicine ,Sleep in non-human animals ,sleep quality ,pre-sleep arousal ,Original Article ,medicine.symptom ,business ,Clinical psychology ,Human - Abstract
Objective The COVID-19 pandemic has strongly affected daily habits and psychological wellbeing, and many studies point to large modifications in several sleep and sleep-related domains. Nevertheless, pre-sleep arousal during the pandemic has been substantially overlooked. Since hyperarousal represents one of the main factors for the development and the perpetuation of chronic insomnia disorder, the assessment of variables associated with high levels of pre-sleep arousal during the pandemic is clinically relevant. The study aimed to assess the prevalence and predictors of perceived sleep quality and pre-sleep arousal in an Italian sample during the COVID-19 lockdown. Methods We used an online survey to collect self-reported sociodemographic, environmental, clinical, sleep, and sleep-related data. Our final sample included 761 participants. Results Beyond a high frequency of poor sleep quality, depressive and stress symptoms, our results show that almost half of the sample suffered from clinically relevant levels of at least one component (ie, cognitive, somatic) of pre-sleep arousal. Subjects with greater pre-sleep arousal exhibited poorer sleep quality. Also, sleep quality was strongly associated with somatic and cognitive pre-sleep arousal. Regarding the predictors of sleep and sleep-related measures, depressive and event-related stress symptoms were the main factors associated with both poor sleep quality and pre-sleep arousal components. Moreover, specific sociodemographic and environmental variables were uniquely related to sleep quality, cognitive or somatic pre-sleep arousal. Conclusions These findings suggest that the assessment of specific sleep-related factors (ie, pre-sleep arousal), together with more global measures of sleep quality, may be crucial to depict the complex impact of the pandemic on sleep, and to help prevent and counteract the spread of insomnia symptoms.
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- 2021
62. Sleep disorders in Prader-Willi syndrome, evidence from animal models and humans
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Flavia Napoli, Valter Tucci, Marta Pace, Fabrizio De Carli, Mohamad Maghnie, Lino Nobili, Matteo Cataldi, Dario Arnaldi, and Giuseppa Patti
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Pulmonary and Respiratory Medicine ,Sleep Wake Disorders ,congenital, hereditary, and neonatal diseases and abnormalities ,CSA ,Excessive daytime sleepiness ,Hypersomnolence ,Hypothalamus ,Narcolepsy ,Orexin ,OSA ,Prader Willi Syndrome ,SDB ,Disorders of Excessive Somnolence ,Bioinformatics ,03 medical and health sciences ,0302 clinical medicine ,Sleep Apnea Syndromes ,Physiology (medical) ,Medicine ,Animals ,Humans ,business.industry ,Genetic disorder ,nutritional and metabolic diseases ,Cognition ,medicine.disease ,Sleep in non-human animals ,Comorbidity ,Pathophysiology ,nervous system diseases ,030228 respiratory system ,Neurology ,Models, Animal ,Neurology (clinical) ,medicine.symptom ,business ,Prader-Willi Syndrome ,030217 neurology & neurosurgery - Abstract
Prader-Willi Syndrome (PWS) is a complex genetic disorder with multiple cognitive, behavioral and endocrine dysfunctions. Sleep alterations and sleep disorders such as Sleep-disordered breathing and Central disorders of hypersomnolence are frequently recognized (either isolated or in comorbidity). The aim of the review is to highlight the pathophysiology and the clinical features of sleep disorders in PWS, providing the basis for early diagnosis and management. We reviewed the genetic features of the syndrome and the possible relationship with sleep alterations in animal models, and we described sleep phenotypes, diagnostic tools and therapeutic approaches in humans. Moreover, we performed a meta-analysis of cerebrospinal fluid orexin levels in patients with PWS; significantly lower levels of orexin were detected in PWS with respect to control subjects (although significantly higher than the ones of narcoleptic patients). Sleep disorders in humans with PWS are multifaceted and are often the result of different mechanisms. Since hypothalamic dysfunction seems to partially influence metabolic, respiratory and sleep/wake characteristics of this syndrome, additional studies are required in this framework.
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- 2021
63. Probing the Role of a Regional Quantitative Assessment of Amyloid PET
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Paolo Bosco, Dario Arnaldi, Matteo Pardini, Flavio Nobili, Francesco Sensi, Silvia Morbelli, Andrea Chincarini, Enrico Peira, Matteo Bauckneht, and Matteo Grazzini
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0301 basic medicine ,Male ,Amyloid ,Trail Making Test ,Standardized uptake value ,Neuropsychological Tests ,Verbal learning ,Brain mapping ,standardized uptake value ratio ,03 medical and health sciences ,0302 clinical medicine ,Alzheimer Disease ,Image Processing, Computer-Assisted ,Verbal fluency test ,Medicine ,Humans ,semi-quantification ,Neuropsychological assessment ,Gray Matter ,ELBA ,Aged ,Amyloid PET ,regional amyloid ,Aged, 80 and over ,Brain Mapping ,medicine.diagnostic_test ,business.industry ,Verbal Behavior ,General Neuroscience ,Cognition ,General Medicine ,Amyloidosis ,Middle Aged ,Verbal Learning ,Psychiatry and Mental health ,Clinical Psychology ,030104 developmental biology ,Positron-Emission Tomography ,Stroop Test ,Female ,Geriatrics and Gerontology ,business ,Neuroscience ,030217 neurology & neurosurgery ,Stroop effect - Abstract
Background: In clinical practice, the amy-PET is globally inspected to provide a binary outcome, but the role of a regional assessment has not been fully investigated yet. Objective: To deepen the role of regional amyloid burden and its implication on clinical-neuropsychological features. Materials: Amy-PET and a complete neuropsychological assessment (Trail Making Test, Rey Auditory Verbal Learning Test, semantic verbal fluency, Symbol Digit, Stroop, visuoconstruction) were available in 109 patients with clinical suspicion of Alzheimer’s disease. By averaging the standardized uptake value ratio and ELBA, a regional quantification was calculated for each scan. Patients were grouped according to their overall amyloid load: correlation maps, based on regional quantification, were calculated and compared. A regression analysis between neuropsychological assessment and the regional amyloid-β (Aβ) load was carried out. Results: Significant differences were observed between the correlation maps of patients at increasing levels of Aβ and the overall dataset. The Aβ uptake of the subcortical gray matter resulted not related to other brain regions independently of the global Aβ level. A significant association of semantic verbal fluency was observed with ratios of cortical and subcortical distribution of Aβ which represent a coarse measure of differences in regional distribution of Aβ. Conclusion: Our observations confirmed the different susceptibility to Aβ accumulation among brain regions. The association between cognition and Aβ distribution deserves further investigations: it is possibly due to a direct local effect or it represents a proxy marker of a more aggressive disease subtype. Regional Aβ assessment represents an available resource on amy-PET scan with possibly clinical and prognostic implications.
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- 2021
64. Sex differences in neuroimaging biomarkers in healthy subjects and dementia
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Silvia Morbelli, Federico Massa, Enrico Peira, Matteo Pardini, Dario Arnaldi, Riccardo Meli, Matteo Bauckneht, Caterina Lapucci, Stefano Raffa, Flavio Nobili, Andrea Chincarini, Michele Balma, Luca Roccatagliata, Matteo Grazzini, and Pilar M. Ferraro
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Neuroimaging ,Functional neuroimaging ,business.industry ,Confounding ,Healthy subjects ,medicine ,Dementia ,Neuroimaging biomarkers ,medicine.disease ,business ,Clinical psychology - Abstract
Several studies have investigated sex differences in morphological and functional neuroimaging in healthy conditions, but few data are available on the specific effect of sex on neuroimaging in dementia and related disorders. Sex is more often considered as a confounding variable than as a variable of interest. Furthermore, especially in the dementia field, the data are drawn from studies designed for other specific aims, and discrepant results are often found due to different equipment, studied cohorts, and analytical methods. Notably, investigating this aspect would be pivotal to better understand how age-related diseases, such as dementia, differentially impact on the main correlates of brain functions in males and females. We review some of the main findings of the literature, highlighting the need for a more systematic appraisal of sex and even gender differences in future neuroimaging studies.
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- 2021
65. The fate of patients with REM sleep behavior disorder and Mild Cognitive Impairment
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Andrea Brugnolo, Matteo Pardini, Fabrizio De Carli, Matteo Bauckneht, Federico Massa, Andrea Chincarini, Nicola Girtler, Francesco Famà, Silvia Morbelli, Dario Arnaldi, Cristina Schenone, Riccardo Meli, and Flavio Nobili
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Male ,medicine.medical_specialty ,Constipation ,Synucleinopathies ,Polysomnography ,Sleep, REM ,Physical examination ,REM Sleep Behavior Disorder ,Logistic regression ,REM sleep behavior disorder ,03 medical and health sciences ,0302 clinical medicine ,Neuroimaging ,Internal medicine ,medicine ,Humans ,Cognitive Dysfunction ,medicine.diagnostic_test ,business.industry ,Dopaminergic ,Neuropsychology ,General Medicine ,medicine.disease ,030228 respiratory system ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Objective To investigate clinical and dopaminergic pre-synaptic brain imaging characteristics of subjects with idiopathic rapid eye movement (REM) behavior disorder (iRBD) and mild cognitive impairment (MCI), and to evaluate the combined predictive value of risk factors for short-term conversion to synucleinopathy. Method In sum, 44 polysomnography (PSG)-confirmed iRBD patients (68.5 ± 7.2 years; 38 males) underwent 123I-FP-CIT-SPECT, comprehensive neuropsychological evaluation, clinical examination and clinical follow-up every six months (30.6 ± 21.5 months). Step-wise logistic regression was applied to identify those features discriminating iRBD patients with (iRBD-MCI; n = 14) and without MCI (normal cognition [NC], iRBD-NC; n = 30). The risk of neurodegeneration was estimated with Kaplan–Meier analysis. Predictors of phenoconversion were assessed with Cox proportional-hazards analysis, adjusting for age, gender and education. A generalized linear model (GLM) was applied to define the best combination of risk factors predicting conversion at follow-up. Results At baseline, patients with iRBD-MCI showed reduced striatal dopamine transporter (DAT) specific to non-displaceable binding ratio (SBR) and more constipation compared with iRBD-NC patients (p Conclusions iRBD-MCI patients showed a more severe dopaminergic neuroimaging and clinical phenotype. Combining clinical and neuroimaging markers allowed to achieve excellent ability in identifying iRBD patients at high risk of developing a synucleinopathy within about three years from diagnosis.
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- 2021
66. Contributors
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Carla Abdelnour, Angela Abela, Dario Arnaldi, Rhoda Au, Michele Balma, Paola Barbarino, Mariagnese Barbera, Matteo Bauckneht, Staci D. Bilbo, Ewelina Biskup, Stephen Campbell, Antonella Santuccione Chadha, Andrea Chincarini, Charlotte Delage, Annemarie Schumacher Dimech, Nicola Diviani, Sue Downie, Ester Esteban, Pilar M. Ferraro, Maria Teresa Ferretti, Nancy S. Foldi, Liisa A.M. Galea, Emnet Z. Gammada, Matteo Grazzini, Krister Håkansson, MaryJane Hill-Strathy, Stefania Ilinca, Stefania Ippati, Lars Matthias Ittner, Valeria Jordan, Yazi Diana Ke, Miia Kivipelto, Caterina Lapucci, Bonnie H. Lee, Jenni Lehtisalo, Klara Lorenz-Dant, Chris Lynch, Karen E. Malacon, Julie N. Martinkova, Federico Massa, Riccardo Meli, Simona Mellino, Michelle M. Mielke, Mary Mittelman, Silvia Morbelli, Beatrice Nasta, Flavio Nobili, Matteo Pardini, Enrico Peira, Susan Phillips, Tanvi A. Puri, Stefano Raffa, Katrin Rauen, Danielle N. Rendina, Luca Roccatagliata, Anna Rosenberg, Maitee Rosende-Roca, Mercè Boada Rovira, Sara Rubinelli, Anthony Scerri, Charles Scerri, Shireen Sindi, Ruth Stephen, Elina Suzuki, Cassandra Szoeke, Sima Toopchiani, Marie-Ève Tremblay, Chinedu Udeh-Momoh, and Wendy Weidner
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- 2021
67. Phase and amplitude electroencephalography correlations change with disease progression in people with idiopathic rapid eye-movement sleep behavior disorder
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Beatrice Orso, Flavio Nobili, Gabriele Arnulfo, Dario Arnaldi, Pietro Mattioli, Monica Roascio, Andrea Canessa, Rosella Trò, Francesco Famà, Laura Giorgetti, S. Morbelli, Nicola Girtler, Neuroscience Center, and Helsinki Institute of Life Science HiLIFE
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Male ,medicine.medical_specialty ,rapid eye-movement sleep behavior disorder ,MILD COGNITIVE IMPAIRMENT ,Rapid eye movement sleep ,Alpha (ethology) ,REM Sleep Behavior Disorder ,Electroencephalography ,Audiology ,3124 Neurology and psychiatry ,03 medical and health sciences ,0302 clinical medicine ,PARKINSONS-DISEASE ,Physiology (medical) ,medicine ,Humans ,Dementia ,AcademicSubjects/MED00385 ,Cognitive decline ,ALZHEIMERS ,SCALE ,030304 developmental biology ,cognitive impairment ,0303 health sciences ,medicine.diagnostic_test ,AcademicSubjects/SCI01870 ,business.industry ,CORTICAL SOURCE CONNECTIVITY ,Parkinsonism ,Neuropsychology ,NEURODEGENERATION ,3112 Neurosciences ,Brain ,Original Articles ,FUNCTIONAL CONNECTIVITY ,medicine.disease ,Phase synchronization ,3. Good health ,hypersynchronization ,REM-SLEEP ,SYNCHRONIZATION ,Disease Progression ,Neurology (clinical) ,Sleep ,business ,ALPHA RHYTHMS ,030217 neurology & neurosurgery ,AcademicSubjects/MED00370 - Abstract
Study Objectives Increased phase synchronization in electroencephalography (EEG) bands might reflect the activation of compensatory mechanisms of cognitive decline in people with neurodegenerative diseases. Here, we investigated whether altered large-scale couplings of brain oscillations could be linked to the balancing of cognitive decline in a longitudinal cohort of people with idiopathic rapid eye-movement sleep behavior disorder (iRBD). Methods We analyzed 18 patients (17 males, 69.7 ± 7.5 years) with iRBD undergoing high-density EEG (HD-EEG), presynaptic dopaminergic imaging, and clinical and neuropsychological (NPS) assessments at two time points (time interval 24.2 ± 5.9 months). We thus quantified the HD-EEG power distribution, orthogonalized amplitude correlation, and weighted phase-lag index at both time points and correlated them with clinical, NPS, and imaging data. Results Four patients phenoconverted at follow-up (three cases of parkinsonism and one of dementia). At the group level, NPS scores decreased over time, without reaching statistical significance. However, alpha phase synchronization increased and delta amplitude correlations decreased significantly at follow-up compared to baseline. Both large-scale network connectivity metrics were significantly correlated with NPS scores but not with sleep quality indices or presynaptic dopaminergic imaging data. Conclusions These results suggest that increased alpha phase synchronization and reduced delta amplitude correlation may be considered electrophysiological signs of an active compensatory mechanism of cognitive impairment in people with iRBD. Large-scale functional modifications may be helpful biomarkers in the characterization of prodromal stages of alpha-synucleinopathies.
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- 2021
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68. Resting State Alpha Electroencephalographic Rhythms Are Affected by Sex in Cognitively Unimpaired Seniors and Patients with Alzheimer's Disease and Amnesic Mild Cognitive Impairment: A Retrospective and Exploratory Study
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Giuseppe Noce, Claudio Babiloni, Roberta Lizio, Moira Marizzoni, Raffaele Ferri, Susanna Lopez, Lutfu Hanoglu, Fabrizio Stocchi, Laura Vacca, Fernando Díaz, Paolo Onorati, Andrea Soricelli, Bahar Güntekin, Dario Arnaldi, Ebru Yıldırım, Claudio Del Percio, Francesco Famà, Flavio Nobili, Fernando Maestú, Montserrat Zurrón, Virginia Cipollini, Carla Buttinelli, Giovanni B. Frisoni, Duygu Hünerli Gündüz, Federico Tucci, Görsev Yener, Franco Giubilei, and Ivan Lorenzo
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Male ,medicine.medical_specialty ,Cognitive Neuroscience ,media_common.quotation_subject ,Rest ,Exploratory research ,Alpha (ethology) ,Disease ,Audiology ,Affect (psychology) ,Cellular and Molecular Neuroscience ,Cerebrospinal fluid ,Rhythm ,Alzheimer Disease ,medicine ,Humans ,sex ,Cognitive Dysfunction ,media_common ,Aged ,Retrospective Studies ,Cerebral Cortex ,Resting state fMRI ,business.industry ,resting state electroencephalographic (rsEEG) rhythms ,exact low-resolution brain electromagnetic source tomography (eLORETA) ,mild cognitive impairment due to Alzheimer’s disease (ADMCI) ,Electroencephalography ,Alpha Rhythm ,Female ,business ,Vigilance (psychology) - Abstract
In the present retrospective and exploratory study, we tested the hypothesis that sex may affect cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms recorded in normal elderly (Nold) seniors and patients with Alzheimer’s disease and mild cognitive impairment (ADMCI). Datasets in 69 ADMCI and 57 Nold individuals were taken from an international archive. The rsEEG rhythms were investigated at individual delta, theta, and alpha frequency bands and fixed beta (14–30 Hz) and gamma (30–40 Hz) bands. Each group was stratified into matched females and males. The sex factor affected the magnitude of rsEEG source activities in the Nold seniors. Compared with the males, the females were characterized by greater alpha source activities in all cortical regions. Similarly, the parietal, temporal, and occipital alpha source activities were greater in the ADMCI-females than the males. Notably, the present sex effects did not depend on core genetic (APOE4), neuropathological (Aβ42/phospho-tau ratio in the cerebrospinal fluid), structural neurodegenerative and cerebrovascular (MRI) variables characterizing sporadic AD-related processes in ADMCI seniors. These results suggest the sex factor may significantly affect neurophysiological brain neural oscillatory synchronization mechanisms underpinning the generation of dominant rsEEG alpha rhythms to regulate cortical arousal during quiet vigilance.
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- 2021
69. Dopaminergic and Serotonergic Degeneration and Cortical [18 F]Fluorodeoxyglucose Positron Emission Tomography in De Novo Parkinson's Disease
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Silvia Chiola, Dario Arnaldi, Beatrice Orso, Flavio Nobili, Matteo Pardini, Silvia Morbelli, Federico Massa, Pietro Mattioli, Nicola Girtler, Matteo Bauckneht, Elisa Doglione, Erica Biassoni, Roberto Fancellu, and Andrea Brugnolo
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0301 basic medicine ,medicine.medical_specialty ,Parkinson's disease ,striatum ,Thalamus ,cortical degeneration ,nigrostriatal degeneration ,thalamus ,Striatum ,Serotonergic ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Monoaminergic ,medicine ,medicine.diagnostic_test ,business.industry ,Putamen ,Dopaminergic ,medicine.disease ,030104 developmental biology ,Endocrinology ,Neurology ,Positron emission tomography ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Background Degeneration of the nigrostriatal dopaminergic (DA) and the raphe-thalamic serotonergic (SE) systems is among the earliest changes observed in Parkinson's disease (PD). The consequences of those changes on brain metabolism, especially regarding their impact on the cortex, are poorly understood. Objectives Using multi-tracer molecular imaging, we assessed in a cohort of drug-naive PD patients the association between cortical metabolism and DA and SE system deafferentation of either striatum or thalamus, and we explored whether this association was mediated by either striatum or thalamus metabolism. Methods We recruited 96 drug-naive PD patients (aged 71.9 ± 7.5 years) who underwent [123 I]ioflupane single-photon emission computed tomography ([123 I]FP-CIT-SPECT) and brain [18 F]fluorodeoxyglucose positron emission tomography ([18 F]FDG-PET). We used a voxel-wise analysis of [18 F]FDG-PET images to correlate regional metabolism with striatal DA and thalamic SE innervation as assessed using [123 I]FP-CIT-SPECT. Results We found that [123 I]FP-CIT specific to nondisplaceable binding ratio (SBR) and glucose metabolism positively correlated with one another in the deep gray matter (thalamus: P = 0.001, r = 0.541; caudate P = 0.001, r = 0.331; putamen P = 0.001, r = 0.423). We then observed a direct correlation between temporoparietal metabolism and caudate DA innervation, as well as a direct correlation between prefrontal metabolism and thalamus SE innervation. The effect of caudate [123 I]FP-CIT SBR values on temporoparietal metabolism was mediated by caudate metabolic values (percentage mediated: 89%, P-value = 0.008), and the effect of thalamus [123 I]FP-CIT SBR values on prefrontal metabolism was fully mediated by thalamus metabolic values (P Conclusions These data suggest that the impact of deep gray matter monoaminergic deafferentation on cortical function is mediated by striatal and thalamic metabolism in drug-naive PD. © 2021 International Parkinson and Movement Disorder Society.
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- 2021
70. Classification of patients with alzheimer's disease and dementia with lewy bodies using resting EEG selected features at sensor and source levels: A proof-of-concept study
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Dario Arnaldi, Laura Bonanni, Fabrizia D'Antonio, Claudio Del Percio, Fabrizio Stocchi, Francisco J. Fraga, Susanna Lopez, Rodrigo San-Martin, Lutfu Hanoglu, Raffaele Ferri, Bahar Güntekin, Marco Onofrj, Ian G. McKeith, Claudio Babiloni, Roberta Lizio, Carlo de Lena, Flavio Nobili, Giuseppe Noce, and John-Paul Taylor
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Lewy Body Disease ,Alzheimer's Disease ,EEG Source Connectivity ,Feature Selection ,LORETA ,Lewy Body Dementia ,Machine Learning ,Feature selection ,Disease ,Electroencephalography ,Alzheimer Disease ,Feature (machine learning) ,Humans ,Medicine ,Cognitive Dysfunction ,Cerebral Cortex ,Artificial neural network ,medicine.diagnostic_test ,business.industry ,Dementia with Lewy bodies ,Pattern recognition ,Cognition ,medicine.disease ,Support vector machine ,Neurology ,Neurology (clinical) ,Artificial intelligence ,business - Abstract
Background: Early differentiation between Alzheimer’s disease (AD) and Dementia with Lewy Bodies (DLB) is important for accurate prognosis, as DLB patients typically show faster disease progression. Cortical neural networks, necessary for human cognitive function, may be disrupted differently in DLB and AD patients, allowing diagnostic differentiation between AD and DLB. Objective: This proof-of-concept study assessed whether the application of machine learning techniques to data derived from resting-state electroencephalographic (rsEEG) rhythms (discriminant sensor power, 19 electrodes) and source connectivity (between five cortical regions of interest) allowed differentiation between DLB and AD. Methods: Clinical, demographic, and rsEEG datasets from DLB patients (N=30), AD patients (N=30), and control seniors (NOld, N=30), matched for age, sex, and education, were taken from our international database. Individual (delta, theta, alpha) and fixed (beta) rsEEG frequency bands were included. The rsEEG features for the classification task were computed at both sensor and source levels. The source level was based on eLORETA freeware toolboxes for estimating cortical source activity and linear lagged connectivity. Fluctuations of rsEEG recordings (band-pass waveform envelopes of each EEG rhythm) were also computed at both sensor and source levels. After blind feature reduction, rsEEG features served as input to support vector machine (SVM) classifiers. Discrimination of individuals from the three groups was measured with standard performance metrics (accuracy, sensitivity, and specificity). Results: The trained SVM two-class classifiers showed classification accuracies of 97.6% for NOld vs. AD, 99.7% for NOld vs. DLB, and 97.8% for AD vs. DLB. Three-class classifiers (AD vs. DLB vs. NOld) showed classification accuracy of 94.79%. Conclusion: These promising preliminary results should encourage future prospective and longitudinal cross-validation studies using higher resolution EEG techniques and harmonized clinical procedures to enable the clinical application of these machine learning techniques.
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- 2021
71. Different abnormalities of electroencephalographic (EEG) markers in quiet wakefulness are related to visual hallucinations in patients with Parkinson’s and Lewy body diseases
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Claudio Babiloni, Susanna Lopez, Maria Teresa Pascarelli, Roberta Lizio, Giuseppe Noce, Raffaele Ferri, Andrea Soricelli, Flavio Mariano Nobili, Dario Arnaldi, Francesco Famà, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Marco Salvetti, Virginia Cipollini, Laura Bonanni, Raffaella Franciotti, Marco Onofrj, Peter Fuhr, Ute Gschwandtner, Gerhard Ransmayr, Dag Aarsland, Lucilla Parnetti, Lucia Farotti, Moira Marizzoni, Fabrizia D'Antonio, Carlo de Lena, Bahar Güntekin, Lutfu Hanoğlu, Görsev Yener, Derya Durusu Emek‐Savas, Antonio Ivano Triggiani, John‐Paul Taylor, Ian McKeith, Fabrizio Stocchi, Laura Vacca, Harald Hampel, Giovanni B Frisoni, Maria Francesca De Pandis, and Claudio Del Percio
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Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Neurology (clinical) ,Geriatrics and Gerontology - Published
- 2020
72. Different abnormalities of electroencephalographic (EEG) markers in quiet wakefulness are related to motor visual hallucinations in patients with Parkinson’s and Lewy body diseases
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Giovanni B. Frisoni, Moira Marizzoni, Ian G. McKeith, Dag Aarsland, Raffaele Ferri, Susanna Lopez, Görsev Yener, Lutfu Hanoglu, Gerhard Ransmayr, Maria Teresa Pascarelli, Laura Vacca, Lucia Farotti, Lucilla Parnetti, Carlo de Lena, Andrea Soricelli, Flavio Nobili, Marco Onofrj, Bahar Güntekin, John-Paul Taylor, Raffaella Franciotti, Laura Bonanni, Dario Arnaldi, Maria Francesca De Pandis, Peter Fuhr, Fabrizia D'Antonio, Ute Gschwandtner, Claudio Del Percio, Antonio Ivano Triggiani, Fabrizio Stocchi, Francesco Famà, Harald Hampel, Giuseppe Noce, Roberta Lizio, Derya Durusu Emek-Savaş, and Claudio Babiloni
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medicine.medical_specialty ,medicine.diagnostic_test ,Lewy body ,Epidemiology ,business.industry ,Health Policy ,Electroencephalography ,Audiology ,medicine.disease ,Visual Hallucination ,Quiet wakefulness ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,medicine ,In patient ,Neurology (clinical) ,Geriatrics and Gerontology ,business - Published
- 2020
73. Striatal Dopamine Transporter Spect Quantification: Head-To-Head Comparison Between Two Three-Dimensional Automatic Tools
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Dario Arnaldi, Silvia Morbelli, Stefano Raffa, Selene Capitanio, Federico Massa, Laura Filippi, Andrea Chincarini, Maria Isabella Donegani, Alberto Miceli, Eugenia Cella, and Flavio Nobili
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lcsh:Medical physics. Medical radiology. Nuclear medicine ,Striatal dopamine ,business.industry ,lcsh:R895-920 ,Parkinsonism ,Putamen ,Short Communication ,Gold standard (test) ,BasGanV2 ,medicine.disease ,Semi-quantification ,Datquant® ,Correlation ,Text mining ,Rating scale ,SPECT ,Dopamine transporter ,Medicine ,Radiology, Nuclear Medicine and imaging ,Parkinson ,business ,Nuclear medicine ,Cardiac imaging - Abstract
Purpose Our aim was to compare a widely distributed commercial tool with an older free software (i) one another, (ii) with a clinical motor score, (iii) versus reading by experts. Procedures We analyzed consecutive scans from one-hundred and fifty-one outpatients submitted to brain DAT SPECT for a suspected parkinsonism. Images were post-processed using a commercial (Datquant®) and a free (BasGanV2) software. Reading by expert was the gold standard. A subset of patients with pathological or borderline scan was evaluated with the clinical Unified Parkinson’s Disease Rating Scale, motor part (MDS-UPDRS-III). Results SBR, putamen-to-caudate (P/C) ratio, and both P and C asymmetries were highly correlated between the two software with Pearson’s ‘r’ correlation coefficients ranging from .706 to .887. Correlation coefficients with the MDS-UPDRS III score were higher with caudate than with putamen SBR values with both software, and in general higher with BasGanV2 than with Datquant®. Datquant® correspondence with expert reading was 84.1% (94.0% by additionally considering the P/C ratio as a further index). BasGanV2 correspondence with expert reading was 80.8% (86.1% by additionally considering the P/C ratio). Conclusions Both Datquant® and BasGanV2 work reasonably well and similarly one another in semi-quantification of DAT SPECT. Both tools have their own strength and pitfalls that must be known in detail by users in order to obtain the best help in visual reading and reporting of DAT SPECT.
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- 2020
74. Cuneus/precuneus as a central hub for brain functional connectivity of mild cognitive impairment in idiopathic REM sleep behavior patients
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Francesco Famà, Alberto Miceli, Nicola Girtler, Riccardo Meli, Andrea Brugnolo, Silvia Morbelli, Dario Arnaldi, Laura Filippi, Michele Terzaghi, Beatrice Orso, Flavio Nobili, Pietro Mattioli, Federico Massa, Matteo Pardini, Stefano Grisanti, and Matteo Bauckneht
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Cingulate cortex ,medicine.medical_specialty ,Precuneus ,Sleep, REM ,18F-FDG-PET ,Mild cognitive impairment (MCI) ,Parkinson’s disease ,Rapid eye movement sleep behavior disorder (RBD) ,Synucleinopathy ,Audiology ,Corpus callosum ,behavioral disciplines and activities ,030218 nuclear medicine & medical imaging ,Cuneus ,03 medical and health sciences ,0302 clinical medicine ,Parietal Lobe ,mental disorders ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Cognitive Dysfunction ,Neuropsychological assessment ,medicine.diagnostic_test ,business.industry ,Neuropsychology ,Brain ,General Medicine ,Executive functions ,medicine.disease ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Occipital Lobe ,business ,human activities - Abstract
To investigate brain functional correlates of mild cognitive impairment (MCI) in idiopathic REM sleep behavior disorder (iRBD). Thirty-nine consecutive iRBD patients, 17 with (RBD-MCI, 73.6±6.5 years), and 22 without (RBD-NC, 69.6±6.1 years) MCI underwent neuropsychological assessment, 18F-FDG-PET, and 123I-FP-CIT-SPECT as a marker of nigro-striatal dopaminergic function. Forty-two healthy subjects (69.6±8.5 years) were used as control for 18F-FDG-PET analysis. Brain metabolism was compared between the three groups by univariate analysis of variance. Post hoc comparison between RBD-MCI and RBD-NC was performed to investigate the presence of an MCI-related volume of interest (MCI-VOI). Brain functional connectivity was explored by interregional correlation analysis (IRCA), using the whole-brain normalized MCI-VOI uptake as the independent variable. Moreover, the MCI-VOI uptake was correlated with 123I-FP-CIT-SPECT specific-to-non displaceable binding ratios (SBR) and neuropsychological variables. Finally, the MCI-VOI white matter structural connectivity was analyzed by using a MRI-derived human atlas. The MCI-VOI was characterized by a relative hypometabolism involving precuneus and cuneus (height threshold p
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- 2020
75. Rapid eye movement sleep behavior disorder: A proof-of-concept neuroprotection study for prodromal synucleinopathies
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Beatrice Orso, Maria Pia Sormani, Flavio Nobili, Matteo Pardini, Riccardo Meli, Federico Massa, Pietro Mattioli, Nicola Girtler, Maria Isabella Donegani, Andrea Brugnolo, Francesco Famà, Matteo Bauckneht, Silvia Morbelli, and Dario Arnaldi
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Male ,medicine.medical_specialty ,Parkinson's disease ,Synucleinopathies ,Rapid eye movement sleep ,REM Sleep Behavior Disorder ,REM sleep behavior disorder ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Dementia ,Humans ,030212 general & internal medicine ,Aged ,Tomography, Emission-Computed, Single-Photon ,Dementia with Lewy bodies ,business.industry ,Parkinsonism ,Putamen ,Selegiline ,Middle Aged ,medicine.disease ,Neuroprotection ,Neurology ,Female ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
BACKGROUND AND PURPOSE To explore the feasibility of a neuroprotection trial in prodromal synucleinopathy, using idiopathic rapid eye movement sleep behavior disorder (iRBD) as the target population and 123 I-FP-CIT-SPECT as a biomarker of disease progression. METHODS Consecutive iRBD patients were randomly assigned to a treatment arm receiving selegiline and symptomatic rapid eye movement sleep behavior disorder treatment, or to a control arm receiving symptomatic treatment only. Selegiline was chosen because of a demonstrated neuroprotection effect in animal models. Patients underwent 123 I-FP-CIT-SPECT at baseline and after 30 months on average. The clinical outcome was the emergence of parkinsonism and/or dementia. A repeated-measures general linear model (GLM) was applied using group (control and treatment) as "between" factor, and both time (baseline and follow-up) and regions (123 I-FP-CIT-SPECT putamen and caudate uptake) as the "within" factors, adjusting for age. RESULTS Thirty iRBD patients completed the study (68.2 ± 6.9 years; 29 males; 21% dropout rate), 13 in the treatment arm, and 17 in the control arm. At follow-up (29.8 ± 9.0 months), three patients in the control arm developed dementia and one parkinsonism, whereas two patients in the treatment arm developed parkinsonism. Both putamen and caudate uptake decreased over time in the control arm. In the treatment arm, only the putamen uptake decreased over time, whereas caudate uptake remained stable. GLM analysis demonstrated an effect of treatment on the 123 I-FP-CIT-SPECT uptake change, with a significant interaction between the effect of group, time, and regions (p = 0.004). CONCLUSIONS A 30-months neuroprotection study for prodromal synucleinopathy is feasible, using iRBD as the target population and 123 I-FP-CIT-SPECT as a biomarker of disease progression.
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- 2020
76. Abnormalities of Cortical Sources of Resting State Alpha Electroencephalographic Rhythms are Related to Education Attainment in Cognitively Unimpaired Seniors and Patients with Alzheimer's Disease and Amnesic Mild Cognitive Impairment
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Tuba Aktürk, Giovanni B. Frisoni, Claudio Babiloni, Dario Arnaldi, Virginia Cipollini, Laura Vacca, Andrea Soricelli, Bahar Güntekin, Claudio Del Percio, Fabrizio Stocchi, Moira Marizzoni, Giuseppe Noce, Andrea Panzavolta, Ivan Lorenzo, Görsev Yener, Carla Buttinelli, Lutfu Hanoglu, Franco Giubilei, Susanna Lopez, Roberta Lizio, Yağmur Özbek, Flavio Nobili, Raffaele Ferri, Francesco Orzi, and Francesco Famà
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Male ,medicine.medical_specialty ,Cognitive Neuroscience ,Rest ,Alpha (ethology) ,Neuropathology ,Audiology ,Neuropsychological Tests ,Affect (psychology) ,Neuroprotection ,Cellular and Molecular Neuroscience ,Alzheimer Disease ,medicine ,Humans ,Cognitive Dysfunction ,Cognitive reserve ,Aged ,Cerebral Cortex ,Resting state fMRI ,business.industry ,aging ,resting state electroencephalographic (rsEEG) rhythms ,Neurodegeneration ,Neuropsychology ,education attainment ,exact low-resolution brain electromagnetic source tomography (eLORETA) ,mild cognitive impairment due to Alzheimer's disease (ADMCI) ,Electroencephalography ,medicine.disease ,mild cognitive impairment due to Alzheimer’s disease (ADMCI) ,Alpha Rhythm ,Educational Status ,Female ,Amnesia ,business - Abstract
In normal old (Nold) and Alzheimer’s disease (AD) persons, a high cognitive reserve (CR) makes them more resistant and resilient to brain neuropathology and neurodegeneration. Here, we tested whether these effects may affect neurophysiological oscillatory mechanisms generating dominant resting state electroencephalographic (rsEEG) alpha rhythms in Nold and patients with mild cognitive impairment (MCI) due to AD (ADMCI). Data in 60 Nold and 70 ADMCI participants, stratified in higher (Edu+) and lower (Edu–) educational attainment subgroups, were available in an Italian–Turkish archive. The subgroups were matched for age, gender, and education. RsEEG cortical sources were estimated by eLORETA freeware. As compared to the Nold-Edu– subgroup, the Nold-Edu+ subgroup showed greater alpha source activations topographically widespread. On the contrary, in relation to the ADMCI-Edu– subgroup, the ADMCI-Edu+ subgroup displayed lower alpha source activations topographically widespread. Furthermore, the 2 ADMCI subgroups had matched cerebrospinal AD diagnostic biomarkers, brain gray–white matter measures, and neuropsychological scores. The current findings suggest that a high CR may be related to changes in rsEEG alpha rhythms in Nold and ADMCI persons. These changes may underlie neuroprotective effects in Nold seniors and subtend functional compensatory mechanisms unrelated to brain structure alterations in ADMCI patients.
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- 2020
77. Neurophysiological evaluation of visual function in iRBD: potential role in stratifying RBD conversion risk
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Marina Ranzani, Roberta Zangaglia, Valter Rustioni, Alfredo Romani, Riccardo Cremascoli, Laura Pilati, Maurizio Versino, Ivana Sartori, R. Callieco, Marta Picascia, Claudio Pacchetti, Silvia Colnaghi, Federica Avantaggiato, Michele Terzaghi, and Dario Arnaldi
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medicine.medical_specialty ,Parkinson's disease ,genetic structures ,Evoked potentials ,Neurodegenerative disorders ,Neurophysiology ,Phenoconversion risk ,REM sleep Behavior disorder ,Visual evoked potentials ,REM Sleep Behavior Disorder ,Audiology ,REM sleep behavior disorder ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,business.industry ,Neurodegenerative Diseases ,Parkinson Disease ,General Medicine ,medicine.disease ,030228 respiratory system ,Visual function ,Evoked Potentials, Visual ,business ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
Study objectives To evaluate neurophysiological alterations of visual function in idiopathic REM sleep Behavior Disorder (iRBD) both as markers and predictors of neurodegenerative disorders. Methods In a longitudinal follow-up study of 46 consecutive iRBD patients (follow-up duration 8.4 ± 3.4 years), the baseline parameters in luminance-contrast pattern (VEPp), red-green color (VEPc) and motion-onset (VEPm) Visual Evoked Potentials in iRBD were compared to early (ePD) and advanced (aPD) Parkinson's Disease subjects. Parameters of latency and amplitude of iRBD converters to neurodegenerative disease were compared with those of the non-converters. Results The VEP P100 mean latency values for both eyes and for both stimulation checks (30′ and 15’) were significantly longer in all the three groups of patients as compared to controls; moreover latencies were longer in aPD than in the iRBD group who did not differ from the ePD group. The same held true when we analyzed the number of abnormal subjects belonging to each diagnostic group with a higher number of abnormal subjects in the aPD group compared to both the ePD and in iRBD groups. Chromatic and motion potentials were not different from controls and did not differ in the 3 diagnostic groups. The iRBD subjects who converted to a neurodegenerative disorder showed longer P100 latencies and a higher occurrence of VEPp abnormalities than those who did not convert. Again chromatic and motion VEPs were not different depending on conversion. Conclusions In iRBD patients the detection of an abnormal VEPp should be considered as a red flag for possible synnucleinopathy, eventually contributing in stratifying the risk of phenoconversion.
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- 2020
78. Epilepsy course during COVID-19 pandemic in three Italian epilepsy centers
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Corrado Cabona, Lucio Marinelli, Claudia Buffoni, Flavio Villani, Francesco Deleo, Marco de Curtis, Eleonora Arboscello, Daniela Audenino, Dario Arnaldi, Francesca Rossi, Roberta Di Giacomo, Giuseppa Jolanda Rosa, and Giuseppe Didato
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Adult ,Male ,Telemedicine ,medicine.medical_specialty ,Isolation (health care) ,COVID-19 ,Epilepsy ,First seizure ,Status epilepticus ,Pneumonia, Viral ,Clinical Neurology ,Article ,Cohort Studies ,03 medical and health sciences ,Behavioral Neuroscience ,Betacoronavirus ,0302 clinical medicine ,Status Epilepticus ,Recurrence ,Seizures ,Pandemic ,Prevalence ,Medicine ,Humans ,030212 general & internal medicine ,Prospective Studies ,Pandemics ,Referral and Consultation ,business.industry ,SARS-CoV-2 ,Incidence (epidemiology) ,Incidence ,Emergency department ,Middle Aged ,medicine.disease ,Neurology ,Italy ,Emergency medicine ,Cohort ,Anticonvulsants ,Female ,Neurology (clinical) ,medicine.symptom ,business ,Coronavirus Infections ,030217 neurology & neurosurgery - Abstract
During epidemic outbreaks, epilepsy course can be modified by different physical and psychological stressors and, most importantly, by irregular therapy intake. The effect of COVID-19 and quarantine isolation on the course of epilepsy and on incidence of new-onset seizures is still unclear. With the aim of managing epilepsy in quarantined patients, three Italian Epilepsy Centers set up telephone consultations using a semistructured interview, allowing a prospective collection of data on seizure course and other seizure-related problems during pandemic. The collected data on seizure course were compared with the analogous period of 2019. The level of patients' concern relating to the COVID-19 pandemic was also assessed using a numeric rating scale. To address the effect of COVID-19 pandemic on seizure incidence, data collection included the number of consultations for first seizures, relapse seizures, and status epilepticus (SE) in the emergency department of one of the participating centers. Clinical telephone interviews suggest the absence of quarantine effect on epilepsy course in our cohort. No differences in incidence of emergency consultations for seizures over a two-month period were also observed compared with a control period. As demonstrated in other infective outbreaks, good antiepileptic drug (AED) supplying, precise information, and reassurance are the most important factors in chronic conditions to minimize psychological and physical stress, and to avoid unplanned treatment interruptions., Highlights • The effect of COVID-19 and quarantine isolation on the course of epilepsy is still unclear. • Epilepsy course during COVID-19 pandemic was assessed through telephone consultations. • COVID-19 pandemic did not change seizure incidence and prevalence in our patient cohort. • In pandemic situations, telemedicine can be a useful tool for epilepsy care.
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- 2020
79. Head-to-Head Comparison among Semi-Quantification Tools of Brain FDG-PET to Aid the Diagnosis of Prodromal Alzheimer's Disease
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Federico Massa, Dario Arnaldi, Bart N.M. van Berckel, Samantha Galluzzi, Rik Ossenkoppele, Eric Guedj, Matteo Grazzini, Marco Pagani, Gianmario Sambuceti, Andrea Chincarini, Cathrine Jonsson, S. Morbelli, Mira Didic, Matteo Bauckneht, Fabrizio De Carli, Patrizia Mecocci, Matteo Pardinia, Alexander Drzezga, Giovanni B. Frisoni, Flavio Nobili, Massimo E. Dottorini, Robert Perneczky, Andrea Brugnolo, Radiology and nuclear medicine, Amsterdam Neuroscience - Neurodegeneration, Neurology, VU University medical center, Institute of Bioimaging and Molecular Physiology [Germaneto], National Research Council [Italy] (CNR), Universita degli studi di Genova, Neuroimaging and Telemedicine (LENITEM), IRCCS Fatebenefratelli - Brescia, University Hospital of the Ludwig-Maximilian-University Munich, Medizinische Klinik â€' Innenstadt, Lehrstuhl für Endokrinologie/Diabetologie, Department of Nuclear Medicine [Cologne], University Hospital of Cologne [Cologne], Service de neurologie et de neuropsychologie, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Service Central de Biophysique et de Médecine Nucléaire, Hôpital de la Timone [CHU - APHM] (TIMONE), Imagerie MOléculaire pour applications THéranostiques personnalisées (IMOTHEP), Institut FRESNEL (FRESNEL), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)- Hôpital de la Timone [CHU - APHM] (TIMONE), DINOGMI Genoa, Physiopathologie du système nerveux central - Institut François Magendie, Université Bordeaux Segalen - Bordeaux 2-IFR8-Institut National de la Santé et de la Recherche Médicale (INSERM), German Aerospace Center (DLR), Institute of Gerontology and Geriatrics, Università degli Studi di Perugia (UNIPG), Clinical Neurophysiology Service, Dept of Endocrinological and Metabolic Sciences, University of Ge, Imperial College London, Centre de résonance magnétique biologique et médicale (CRMBM), Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU)- Hôpital de la Timone [CHU - APHM] (TIMONE), Dipartimento di Neuroscienze, riabilitazione, oftalmologia, genetica e scienze materno-infantili [Genova] (DINOGMI), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Università degli studi di Genova = University of Genoa (UniGe), Centre Européen de Recherche en Imagerie médicale (CERIMED), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-École Centrale de Marseille (ECM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Centre National de la Recherche Scientifique (CNRS), and Università degli Studi di Perugia = University of Perugia (UNIPG)
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Male ,Support Vector Machine ,SPM ,Volumetric region of interest ,Disease ,prodromal Alzheimer's disease ,pAD ,EADC ,Image Processing, Computer-Assisted ,FDG-PET ,ComputingMilieux_MISCELLANEOUS ,Aged, 80 and over ,Statistical parametric mapping ,General Neuroscience ,methods [Positron-Emission Tomography] ,Brain ,Volumetric Region of Interest ,General Medicine ,Middle Aged ,Psychiatry and Mental health ,Clinical Psychology ,Disease Progression ,Female ,Radiology ,Semi quantitative ,medicine.medical_specialty ,Head to head ,European Alzheimer Disease Consortium ,Prodromal Symptoms ,macromolecular substances ,[SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine ,statistical parametric mapping ,Alzheimer Disease ,Fluorodeoxyglucose F18 ,medicine ,Humans ,ddc:610 ,diagnostic imaging [Brain] ,Aged ,Neuroscience (all) ,business.industry ,prodromal Alzheimer’s disease ,[SCCO.NEUR]Cognitive science/Neuroscience ,Prodromal Alzheimer's disease ,carbohydrates (lipids) ,Early Diagnosis ,Head-to-head comparison ,Positron-Emission Tomography ,head-to-head comparison ,volumetric region of interest ,Geriatrics and Gerontology ,business ,European Alzheimer Disease Consortium, FDG-PET, head-to-head comparison, prodromal Alzheimer's disease, statistical parametric mapping, volumetric region of interest, Neuroscience (all), Clinical Psychology, Geriatrics and Gerontology, Psychiatry and Mental Health ,diagnostic imaging [Alzheimer Disease] ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
Background: Several automatic tools have been implemented for semi-quantitative assessment of brain [ 18 ]F-FDG-PET. Objective: We aimed to head-to-head compare the diagnostic performance among three statistical parametric mapping (SPM)-based approaches, another voxel-based tool (i.e., PALZ), and a volumetric region of interest (VROI-SVM)-based approach, in distinguishing patients with prodromal Alzheimer's disease (pAD) from controls. Methods: Sixty-two pAD patients (MMSE score = 27.0±1.6) and one hundred-nine healthy subjects (CTR) (MMSE score = 29.2±1.2) were enrolled in five centers of the European Alzheimer's Disease Consortium. The three SPM-based methods, based on different rationales, included 1) a cluster identified through the correlation analysis between [ 18 ]F-FDG-PET and a verbal memory test (VROI-1), 2) a VROI derived from the comparison between pAD and CTR (VROI-2), and 3) visual analysis of individual maps obtained by the comparison between each subject and CTR (SPM-Maps). The VROI-SVM approach was based on 6 VROI plus 6 VROI asymmetry values derived from the pAD versus CTR comparison thanks to support vector machine (SVM). Results: The areas under the ROC curves between pAD and CTR were 0.84 for VROI-1, 0.83 for VROI-2, 0.79 for SPM maps, 0.87 for PALZ, and 0.95 for VROI-SVM. Pairwise comparisons of Youden index did not show statistically significant differences in diagnostic performance between VROI-1, VROI-2, SPM-Maps, and PALZ score whereas VROI-SVM performed significantly (p < 0.005) better than any of the other methods. Conclusion: The study confirms the good accuracy of [ 18 ]F-FDG-PET in discriminating healthy subjects from pAD and highlights that a non-linear, automatic VROI classifier based on SVM performs better than the voxel-based methods.
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- 2020
80. Dopaminergic imaging and clinical predictors for phenoconversion of REM sleep behaviour disorder
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Karel Sonka, Thomas R Barber, Michele Terzaghi, Michal Rolinski, Fabio Pizza, Petr Dusek, Masayuki Miyamoto, Riccardo Meli, Matteo Bauckneht, Giuseppe Plazzi, Flavio Nobili, Bradley F. Boeve, Alessandra Serra, Lennon Jordan, Jiří Trnka, Raffaele Manni, Andrea Chincarini, Naoko Tachibana, Daniel R. McGowan, Val J. Lowe, Tomoyuki Miyamoto, Silvia Morbelli, Monica Puligheddu, Michela Figorilli, Elena Antelmi, David Zogala, Irene Bossert, Valérie Cochen De Cock, Toji Miyagawa, Dario Arnaldi, Delphine de Verbizier, Kevin M. Bradley, Michele T.M. Hu, Arnaldi, Dario, Chincarini, Andrea, Hu, Michele T, Sonka, Karel, Boeve, Bradley, Miyamoto, Tomoyuki, Puligheddu, Monica, De Cock, Valérie Cochen, Terzaghi, Michele, Plazzi, Giuseppe, Tachibana, Naoko, Morbelli, Silvia, Rolinski, Michal, Dusek, Petr, Lowe, Val, Miyamoto, Masayuki, Figorilli, Michela, de Verbizier, Delphine, Bossert, Irene, Antelmi, Elena, Meli, Riccardo, Barber, Thomas R, Trnka, Jiří, Miyagawa, Toji, Serra, Alessandra, Pizza, Fabio, Bauckneht, Matteo, Bradley, Kevin M, Zogala, David, McGowan, Daniel R, Jordan, Lennon, Manni, Raffaele, and Nobili, Flavio
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Male ,medicine.medical_specialty ,Synucleinopathies ,Unified Parkinson's disease rating scale ,Kaplan-Meier Estimate ,REM Sleep Behavior Disorder ,Logistic regression ,REM sleep behavior disorder ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Aged ,Retrospective Studies ,Tomography, Emission-Computed, Single-Photon ,Dopamine Plasma Membrane Transport Proteins ,Mini–Mental State Examination ,medicine.diagnostic_test ,Proportional hazards model ,business.industry ,Parkinsonism ,Hazard ratio ,Putamen ,Original Articles ,Middle Aged ,medicine.disease ,Confidence interval ,REM sleep behaviour disorder ,ROC Curve ,SPECT ,Parkinson’s disease ,Female ,Neurology (clinical) ,dementia with Lewy bodies ,Caudate Nucleus ,business ,030217 neurology & neurosurgery ,Tropanes - Abstract
This is an international multicentre study aimed at evaluating the combined value of dopaminergic neuroimaging and clinical features in predicting future phenoconversion of idiopathic REM sleep behaviour (iRBD) subjects to overt synucleinopathy. Nine centres sent 123I-FP-CIT-SPECT data of 344 iRBD patients and 256 controls for centralized analysis. 123I-FP-CIT-SPECT images were semiquantified using DaTQUANTTM, obtaining putamen and caudate specific to non-displaceable binding ratios (SBRs). The following clinical variables were also analysed: (i) Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale, motor section score; (ii) Mini-Mental State Examination score; (iii) constipation; and (iv) hyposmia. Kaplan-Meier survival analysis was performed to estimate conversion risk. Hazard ratios for each variable were calculated with Cox regression. A generalized logistic regression model was applied to identify the best combination of risk factors. Bayesian classifier was used to identify the baseline features predicting phenoconversion to parkinsonism or dementia. After quality check of the data, 263 iRBD patients (67.6 ± 7.3 years, 229 males) and 243 control subjects (67.2 ± 10.1 years, 110 males) were analysed. Fifty-two (20%) patients developed a synucleinopathy after average follow-up of 2 years. The best combination of risk factors was putamen dopaminergic dysfunction of the most affected hemisphere on imaging, defined as the lower value between either putamina (P
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- 2020
81. Epilepsy in Neurodegenerative Dementias: A Clinical, Epidemiological, and EEG Study
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Matteo Pardini, Francesco Famà, Elisa Doglione, Laura Filippi, Flavio Villani, Flavio Nobili, Stefano Grisanti, Riccardo Meli, Federico Massa, Andrea Brugnolo, Michele Terzaghi, Andrea Donniaquio, Nicola Girtler, Pietro Mattioli, Matteo Grazzini, and Dario Arnaldi
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0301 basic medicine ,Male ,Pediatrics ,Neuropsychological Tests ,Primary progressive aphasia ,Cohort Studies ,Epilepsy ,0302 clinical medicine ,Positron Emission Tomography Computed Tomography ,Prevalence ,Neuropsychological assessment ,EEG ,Aged, 80 and over ,medicine.diagnostic_test ,General Neuroscience ,Neuropsychology ,Electroencephalography ,Neurodegenerative Diseases ,General Medicine ,Middle Aged ,Mental Status and Dementia Tests ,Magnetic Resonance Imaging ,Psychiatry and Mental health ,Clinical Psychology ,Frontotemporal Dementia ,Cohort ,Anticonvulsants ,Female ,Alzheimer’s disease ,Frontotemporal dementia ,Lewy Body Disease ,medicine.medical_specialty ,seizure ,03 medical and health sciences ,Alzheimer Disease ,mental disorders ,medicine ,Dementia ,Humans ,Aged ,business.industry ,Dementia with Lewy bodies ,medicine.disease ,030104 developmental biology ,dementia ,epilepsy ,Geriatrics and Gerontology ,business ,030217 neurology & neurosurgery - Abstract
Background Seizures are common in patients with dementia but precise epidemiologic data of epilepsy in neurodegenerative dementia is lacking. Objective The first aim of the study was to investigate prevalence and clinical characteristics of epilepsy in a large cohort of patients with neurodegenerative dementias. Subsequently, we explored clinical, neuropsychological, and quantitative electroencephalogram (qEEG) data of Alzheimer's disease (AD) patients with epilepsy (AD-EPI) as compared to AD patients without epilepsy (AD-CTR). Methods We retrospectively evaluated consecutive patients with a diagnosis of a neurodegenerative dementia and a clinically diagnosed epilepsy that required antiepileptic drugs (AED). All patients underwent baseline comprehensive neuropsychological assessment. A follow-up of at least one year was requested to confirm the dementia diagnosis. In AD patients, qEEG power band analysis was performed. AD-CTR and AD-EPI patients were matched for age, Mini-Mental State Examination score, and gender. Results Thirty-eight out of 2,054 neurodegenerative dementia patients had epilepsy requiring AED. The prevalence of epilepsy was 1.82% for AD, 1.28% for the behavioral variant of frontotemporal dementia (bvFTD), 2.47% for dementia with Lewy bodies (DLB), and 12% for primary progressive aphasia. Epilepsy were more drug-responsive in AD than in non-AD dementias. Finally, no significant differences were found in neuropsychological and qEEG data between AD-EPI and AD-CTR patients. Conclusion In our cohort, AD, FTD, and DLB dementias have similar prevalence of epilepsy, even if AD patients were more responsive to AED. Moreover, AD-EPI patients did not have significant clinical, neuropsychological qEEG differences compared with AD-CTR patients.
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- 2020
82. Utility of quantitative EEG in early Lewy body disease
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Matteo Pardini, Matteo Grazzini, Riccardo Meli, Dario Arnaldi, Federico Massa, Fabrizio De Carli, Laura Filippi, Silvia Morbelli, Francesco Famà, and Flavio Nobili
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0301 basic medicine ,Lewy Body Disease ,Male ,medicine.medical_specialty ,Parkinson's disease ,Alpha/theta ratio ,Lewy body disease ,Mild cognitive impairment ,Quantitative EEG ,Electroencephalography ,Quantitative eeg ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,mental disorders ,medicine ,Humans ,Cognitive Dysfunction ,Theta Rhythm ,Cognitive impairment ,Aged ,Aged, 80 and over ,Cerebral Cortex ,medicine.diagnostic_test ,business.industry ,Repeated measures design ,Mean age ,medicine.disease ,Alpha Rhythm ,030104 developmental biology ,Neurology ,Power ratio ,Cardiology ,Female ,Neurology (clinical) ,Geriatrics and Gerontology ,business ,030217 neurology & neurosurgery - Abstract
Introduction The reduction of background activity and the increase of low-frequency powers on electroencephalogram (EEG) correlate with cognitive impairment and have been suggested to be underpinned by cholinergic deficit. We aimed to investigate the ratio between α and θ band power (α/θ ratio), as a synoptic index of quantitative EEG (qEEG) slowing-down, in a peculiar group of patients with mild cognitive impairment (MCI) due to an early-stage Lewy body disease (MCI-LBD), as compared to de novo PD patients without cognitive impairment (PD-MOT), to patients with MCI due to Alzheimer's disease (MCI-AD), and to healthy controls (HC). Methods Twelve patients with MCI-LBD (8 males; mean age 74.8 ± 3.6), 11 PD-MOT, 11 MCI-AD and 24 HC subjects undergoing qEEG were matched for gender, age, and education. Following logarithmic transformation, the α/θ ratio was compared among groups and brain regions by repeated measures ANOVA, also exploring group*regions interactions. Results A significant effect of group (p = 0.0003), regions (p = 0.0001), and group*regions interaction (p = 0.0001) on the α/θ ratio was observed. At post-hoc analysis, α/θ ratio was significantly lower in MCI-LBD (p = 0.001) and in PD-MOT (p = 0.02) compared to HC, and in MCI-LBD than MCI-AD (p = 0.05). No significant differences were found between MCI-AD and HC, as well as between MCI-LBD and PD-MOT. Conclusion The α/θ power ratio as a synoptic index of EEG background slowing-down could be a simple and easy-to-use qEEG index which might indirectly mirror a cholinergic failure, useful to pick-up those MCI patients at higher risk of developing a Lewy-body disease.
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- 2020
83. A kinetics-based approach to amyloid PET semi-quantification
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Flavio Nobili, Matteo Pardini, Dario Arnaldi, Valentina Garibotto, Ugo Paolo Guerra, Matteo Bauckneht, D. D’Ambrosio, Enrico Peira, Giordano Savelli, A. Stefanelli, M. Corosu, C Vellani, Andrea Chincarini, S. Morbelli, Frédéric Assal, Selene Capitanio, and Barbara Paghera
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Tracer kinetic ,Amyloid ,Amyloid PET ,Fluorinated tracer ,Semi-quantification ,Tracer kinetics ,Amyloid pet ,Image processing ,ddc:616.0757 ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,symbols.namesake ,0302 clinical medicine ,Alzheimer Disease ,Visual assessment ,Humans ,Radiology, Nuclear Medicine and imaging ,Mathematics ,Aniline Compounds ,business.industry ,Brain ,Pattern recognition ,General Medicine ,Amyloidosis ,Pearson product-moment correlation coefficient ,ddc:616.8 ,Kinetics ,030220 oncology & carcinogenesis ,Positron-Emission Tomography ,symbols ,Artificial intelligence ,business ,Semi quantitative - Abstract
To develop and validate a semi-quantification method (time-delayed ratio, TDr) applied to amyloid PET scans, based on tracer kinetics information. The TDr method requires two static scans per subject: one early (~ 0–10 min after the injection) and one late (typically 50–70 min or 90–100 min after the injection, depending on the tracer). High perfusion regions are delineated on the early scan and applied onto the late scan. A SUVr-like ratio is calculated between the average intensities in the high perfusion regions and the late scan hotspot. TDr was applied to a naturalistic multicenter dataset of 143 subjects acquired with [18F]florbetapir. TDr values are compared to visual evaluation, cortical–cerebellar SUVr, and to the geometrical semi-quantification method ELBA. All three methods are gauged versus the heterogeneity of the dataset. TDr shows excellent agreement with respect to the binary visual assessment (AUC = 0.99) and significantly correlates with both validated semi-quantification methods, reaching a Pearson correlation coefficient of 0.86 with respect to ELBA. TDr is an alternative approach to previously validated ones (SUVr and ELBA). It requires minimal image processing; it is independent on predefined regions of interest and does not require MR registration. Besides, it takes advantage on the availability of early scans which are becoming common practice while imposing a negligible added patient discomfort.
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- 2020
84. An application of generalized matrix learning vector quantization in neuroimaging
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Vita Gurvits, Rafael Rodriguez-Rojas, Michael Biehl, Remco J. Renken, Dario Arnaldi, Stefano Raffa, Maria C. Rodriguez-Oroz, Bauke M. de Jong, Rick van Veen, Klaus L. Leenders, Rosalie V. Kogan, Gert-Jan de Vries, Sanne K. Meles, Intelligent Systems, Perceptual and Cognitive Neuroscience (PCN), Clinical Cognitive Neuropsychiatry Research Program (CCNP), and Movement Disorder (MD)
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Parkinson's disease (PD) ,Computer science ,Neuroimaging ,Health Informatics ,computer.software_genre ,Cross-validation ,Discriminative model ,Fluorodeoxyglucose F18 ,Voxel ,Humans ,generalized matrix learning vector quantization (GMLVQ) ,Interpretability ,Principal Component Analysis ,Learning vector quantization ,[F]Fluorodeoxyglucose positron emission tomography (FDG-PET) ,business.industry ,Scaled sub-profile scaling model principal component analysis (SSM/PCA) ,Parkinson Disease ,Pattern recognition ,Computer Science Applications ,Visualization ,Europe ,Positron-Emission Tomography ,Principal component analysis ,Artificial intelligence ,business ,computer ,Software - Abstract
BACKGROUND AND OBJECTIVE: Neurodegenerative diseases like Parkinson's disease often take several years before they can be diagnosed reliably based on clinical grounds. Imaging techniques such as MRI are used to detect anatomical (structural) pathological changes. However, these kinds of changes are usually seen only late in the development. The measurement of functional brain activity by means of [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) can provide useful information, but its interpretation is more difficult. The scaled sub-profile model principal component analysis (SSM/PCA) was shown to provide more useful information than other statistical techniques. Our objective is to improve the performance further by combining SSM/PCA and prototype-based generalized matrix learning vector quantization (GMLVQ).METHODS: We apply a combination of SSM/PCA and GMLVQ as a classifier. In order to demonstrate the combination's validity, we analyze FDG-PET data of Parkinson's disease (PD) patients collected at three different neuroimaging centers in Europe. We determine the diagnostic performance by performing a ten times repeated ten fold cross validation. Additionally, discriminant visualizations of the data are included. The prototypes and relevance of GMLVQ are transformed back to the original voxel space by exploiting the linearity of SSM/PCA. The resulting prototypes and relevance profiles have then been assessed by three neurologists.RESULTS: One important finding is that discriminative visualization can help to identify disease-related properties as well as differences which are due to center-specific factors. Secondly, the neurologist assessed the interpretability of the method and confirmed that prototypes are similar to known activity profiles of PD patients.CONCLUSION: We have shown that the presented combination of SSM/PCA and GMLVQ can provide useful means to assess and better understand characteristic differences in FDG-PET data from PD patients and HCs. Based on the assessments by medical experts and the results of our computational analysis we conclude that the first steps towards a diagnostic support system have been taken successfully.
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- 2020
85. Neuroimaging Findings in Mild Cognitive Impairment
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Federico Massa, Matteo Bauckneht, Enrico Peira, Caterina Lapucci, Agnese Picco, Selene Capitanio, Dario Arnaldi, Luca Roccatagliata, Andrea Chincarini, and Flavio Nobili
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- 2020
86. Multicenter Study on Sleep and Circadian Alterations as Objective Markers of Mild Cognitive Impairment and Alzheimer's Disease Reveals Sex Differences
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Dario Arnaldi, Federico Cucchiara, Ubaldo Bonuccelli, Raffaele Manni, Biancamaria Guarnieri, Maria Grazia Arena, G Cerroni, Gloria Tognoni, Rosalia Silvestri, Pietro Mattioli, Ferdinando Franzoni, Maria Caterina Di Perri, Alessandro Schirru, Gabriele Siciliano, Elena Sinforiani, Chiara La Morgia, Ugo Faraguna, Annalisa Lo Gerfo, Enrica Bonanni, Michele Terzaghi, Flavio Nobili, Sandro Sorbi, Michelangelo Mancuso, Michelangelo Maestri, Gemma Lombardi, and Antonella Bartoli
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Male ,Sleep Wake Disorders ,sex differences ,medicine.medical_specialty ,Alzheimer's disease ,circadian rhythms ,confusion matrix ,mild cognitive impairment ,sleep disturbances ,sleep parameters ,sleep regularity index ,wearable activity tracker ,Population ,Disease ,Sex Factors ,Alzheimer Disease ,Internal medicine ,medicine ,Humans ,Cognitive Dysfunction ,Circadian rhythm ,education ,Cognitive impairment ,Aged ,Aged, 80 and over ,education.field_of_study ,Disease trajectory ,business.industry ,General Neuroscience ,General Medicine ,Middle Aged ,Actigraphy ,Sleep in non-human animals ,Circadian Rhythm ,Alzheimer’s disease ,Psychiatry and Mental health ,Clinical Psychology ,Multicenter study ,Case-Control Studies ,Female ,Geriatrics and Gerontology ,Sleep onset ,Sleep ,business - Abstract
Background: Circadian and sleep disturbances are associated with increased risk of mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Wearable activity trackers could provide a new approach in diagnosis and prevention. Objective: To evaluate sleep and circadian rhythm parameters, through wearable activity trackers, in MCI and AD patients as compared to controls, focusing on sex dissimilarities. Methods: Based on minute level data from consumer wearable devices, we analyzed actigraphic sleep parameters by applying an electromedical type I registered algorithm, and the corresponding circadian variables in 158 subjects: 86 females and 72 males (42 AD, 28 MCI, and 88 controls). Moreover, we used a confusion-matrix chart method to assess accuracy, precision, sensitivity, and specificity of two decision-tree models based on actigraphic data in predicting disease or health status. Results: Wake after sleep onset (WASO) was higher (p
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- 2020
87. Resting-state electroencephalographic delta rhythms may reflect global cortical arousal in healthy old seniors and patients with Alzheimer's disease dementia
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Fabrizio Stocchi, Raffaele Ferri, Virginia Cipollini, Görsev Yener, Moira Marizzoni, Bahar Güntekin, Francesco Famà, Tuba Aktürk, Andrea Soricelli, Claudio Babiloni, Dario Arnaldi, Franco Giubilei, Claudio Del Percio, Roberta Lizio, Laura Vacca, Francesco Orzi, Giuseppe Noce, Susanna Lopez, Flavio Nobili, Lutfu Hanoglu, Giovanni B. Frisoni, Derya Durusu Emek-Savaş, and Carla Buttinelli
- Subjects
medicine.medical_specialty ,Alzheimer's disease dementia (ADD) ,delta rhythms ,exact low resolution brain electromagnetic source tomography (eLORETA) ,resting state electroencephalographic (rsEEG) rhythms ,Delta rhythms ,Exact low resolution brain electromagnetic source tomography (eLORETA) ,Resting state electroencephalographic (rsEEG) rhythms ,Cerebral Cortex ,Delta Rhythm ,Electroencephalography ,Humans ,Rest ,Wakefulness ,Alzheimer Disease ,Audiology ,050105 experimental psychology ,Arousal ,03 medical and health sciences ,0302 clinical medicine ,Physiology (medical) ,Medicine ,Dementia ,0501 psychology and cognitive sciences ,Donepezil ,medicine.diagnostic_test ,Resting state fMRI ,business.industry ,General Neuroscience ,05 social sciences ,medicine.disease ,Neuropsychology and Physiological Psychology ,Alzheimer's disease ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Extending Basar's theory of event-related EEG oscillations, here we hypothesize that even in quiet wakefulness, transient increases in delta rhythms may enhance global cortical arousal as revealed by the desynchronization of alpha rhythms in normal (Nold) seniors with some derangement in Alzheimer's disease dementia (ADD).Clinical and EEG datasets in 100 ADD and 100 Nold individuals matched as demography, education, and gender were taken from an international archive. Standard delta (< 4 Hz) and alpha1 (8-10.5 Hz) bands were used for the main analysis, while alpha2 (10.5-13 Hz), theta (4-8 Hz), beta1 (13-20 Hz), beta2 (20-35 Hz), and gamma (35-40 Hz) served as controls. In the interpretation, the higher the alpha1 power (density), the lower that arousal. As expected, when compared to the Nold group, the ADD group showed higher global (scalp) power density at the delta-theta band and lower global power density at the alpha-beta bands. As novel findings, we observed that: (1) in the Nold group, the global delta and alpha1-2 power were negatively and linearly correlated; (2) in the ADD group, this correlation was just marginal; and (3) in both Nold and AD groups, the EEG epochs with the highest delta power (median value for stratification) were associated with the lowest global alpha1 power. This effect was related to eLORETA freeware solutions showing maximum alpha1 source activations in posterior cortical regions.These results suggest that even in quiet wakefulness, delta and alpha rhythms are related to each other, and ADD partially affects this cross-band neurophysiological mechanism. Ministry of Health, Italy ; Ministry of Health Italy - Ricerca Corrente (MOH-RC) ; H2020 Marie S. Curie ITN-ETN project with the short title "BBDiag" ; H2020-TWINN-2015 project with the short title "SynaNet"
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- 2020
88. Abnormalities of resting-state EEG in patients with prodromal and overt dementia with Lewy bodies: Relation to clinical symptoms
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Ian G. McKeith, Carla Buttinelli, Maria Francesca De Pandis, Raffaele Ferri, Francesco Famà, Laura Bonanni, Marco Rizzo, Bahar Güntekin, Peter Fuhr, Franco Giubilei, Virginia Cipollini, Moira Marizzoni, Dag Aarsland, Gerhard Ransmayr, Marco Onofri, Andrea Soricelli, Lucilla Parnetti, Maria Teresa Pascarelli, H. Hampel, Francesco Orzi, Marco Salvetti, Claudio Babiloni, Lutfu Hanoglu, Lucia Farotti, John-Paul Taylor, Giuseppe Noce, Görsev Yener, Susanna Lopez, Giovanni B. Frisoni, Raffaella Franciotti, Fabrizia D'Antonio, Antonio Ivano Triggiani, Laura Vacca, Ute Gschwandtner, Roberta Lizio, Fabrizio Stocchi, Derya Durusu Emek-Savaş, Dario Arnaldi, Carlo de Lena, Flavio Nobili, and Claudio Del Percio
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Male ,Hallucinations ,Visual Hallucinations ,0302 clinical medicine ,Mild Cognitive Impairment (MCI) ,Prospective Studies ,Mild cognitive impairment (MCI) ,Cortical Synchronization ,Prospective cohort study ,Exact low-resolution brain electromagnetic source tomography (eLORETA) ,Prodromal and overt dementia with Lewy bodies (DLB) ,Rapid eye movement sleep behavior disorders (RBD) ,Resting state electroencephalographic (EEG) rhythms ,Visual hallucinations ,Cerebral Cortex ,Exact Low-Resolution Brain Electromagnetic Source Tomography (Eloreta) ,medicine.diagnostic_test ,05 social sciences ,Electroencephalography ,Parasomnia ,Sensory Systems ,Alpha Rhythm ,Neurology ,Female ,Alzheimer's disease ,Lewy Body Disease ,medicine.medical_specialty ,Aged ,Cognitive Dysfunction ,Default Mode Network ,Humans ,Prodromal Symptoms ,behavioral disciplines and activities ,050105 experimental psychology ,03 medical and health sciences ,Physiology (medical) ,Internal medicine ,mental disorders ,medicine ,0501 psychology and cognitive sciences ,Mini–Mental State Examination ,Resting state fMRI ,Dementia with Lewy bodies ,Surrogate endpoint ,business.industry ,Resting State Electroencephalographic (EEG) Rhythms ,medicine.disease ,nervous system diseases ,Prodromal and Overt Dementia With Lewy Bodies (DLB) ,Rapid Eye Movement Sleep Behavior Disorders (RBD) ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Objective: Here we tested if cortical sources of resting state electroencephalographic (rsEEG) rhythms may differ in sub-groups of patients with prodromal and overt dementia with Lewy bodies (DLB) as a function of relevant clinical symptoms.Methods: We extracted clinical, demographic and rsEEG datasets in matched DLB patients (N = 60) and control Alzheimer's disease (AD, N = 60) and healthy elderly (Nold, N = 60) seniors from our international database. The eLORETA freeware was used to estimate cortical rsEEG sources.Results: As compared to the Nold group, the DLB and AD groups generally exhibited greater spatially distributed delta source activities (DLB > AD) and lower alpha source activities posteriorly (AD > DLB). As compared to the DLB ``controls", the DLB patients with (1) rapid eye movement (REM) sleep behavior disorders showed lower central alpha source activities (p < 0.005); (2) greater cognitive deficits exhibited higher parietal and central theta source activities as well as higher central, parietal, and occipital alpha source activities (p < 0.01); (3) visual hallucinations pointed to greater parietal delta source activities (p < 0.005).Conclusions: Relevant clinical features were associated with abnormalities in spatial and frequency features of rsEEG source activities in DLB patients.Significance: Those features may be used as neurophysiological surrogate endpoints of clinical symptoms in DLB patients in future cross-validation prospective studies. Ministry of Health, Italy; H2020 Marie S. Curie ITN-ETN project; H2020-TWINN-2015 project
- Published
- 2020
89. NREM sleep arousal-related disorders reflect cognitive impairment in Parkinson's disease
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Riccardo Cremascoli, Nicolò Gabriele Pozzi, Brigida Minafra, Michele Terzaghi, Roberta Zangaglia, Claudio Pacchetti, Marta Picascia, Maurizio Versino, Dario Arnaldi, Elena Sinforiani, Raffaele Manni, and Valter Rustioni
- Subjects
Levodopa ,medicine.medical_specialty ,Parkinson's disease ,REM Sleep Behavior Disorder ,Parkinson's disease dementia ,Non-rapid eye movement sleep ,Arousal ,RBD ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Overlapping parasomnias ,mental disorders ,medicine ,Dementia ,Humans ,Cognitive Dysfunction ,Neuropsychological assessment ,Cognitive decline ,NREM parasomnias ,medicine.diagnostic_test ,business.industry ,MCI in Parkinson's disease ,Cognition ,Parkinson Disease ,General Medicine ,medicine.disease ,030228 respiratory system ,business ,Sleep ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Background Sleep disorders and cognitive impairment are frequently reported in Parkinson's disease (PD) as non-motor disabling symptoms. While it is known that REM sleep Behaviour Disorder (RBD) in PD is associated with motor and cognitive decline, little is known about the neurobiological significance of NREM sleep arousal-related disorders. Objectives: to evaluate the cognitive and clinical correlates of arousal-related disorders in PD. Methods Clinical data and video-polysomnography were analysed from one hundred-seventy consecutive subjects with PD. Based on the neuropsychological assessment, the subjects were divided into three groups: no cognitive impairment (PD; n = 58), mild cognitive impairment (PD-MCI; n = 58) and overt dementia (PDD; n = 54). Results Arousal-related disorders by history were reported in 32.9% of the subjects: 10.3% PD, 31.6% PD-MCI and 59.3% PDD (p = 0.001). Video-PSG captured arousal-related disorders in 1.7% PD, 21.2% MCI-PD and 35.6% PDD (p = 0.001). Arousal-related disorders and RBD were recorded in the same night in 7.7% PD, 9.8% MCI-PD and 15.6% PDD (p = 0.04). Patients with arousal-related disorders captured at V-PSG have a longer disease duration (p = 0.003), higher UPDRS score (p = 0.039), longer duration of treatment with levodopa (p = 0.017) and dopamine agonists (p = 0.018), worse H&Y staging (p = 0.001), lower MMSE score (p = 0.019) and more frequently hallucinations (p = 0.004). In multivariate analysis, cognitive impairment significantly increases the risk of arousal-related disorders (OR 3.387–95% CI 1.395–8.220, p = 0.007). Conclusion Arousal-related disorders appear to be a marker of cognitive decline in PD. Recognizing arousal-related disorders should make clinicians aware of a possible cognitive decline in PD and eventually modify the therapeutic approach.
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- 2020
90. Abnormal cortical neural synchronization mechanisms in quiet wakefulness are related to motor deficits, cognitive symptoms, and visual hallucinations in Parkinson's disease patients: an electroencephalographic study
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Ian G. McKeith, H. Hampel, Dario Arnaldi, Francesco Orzi, Carla Buttinelli, Marco Salvetti, Laura Bonanni, Paola Stirpe, Susanna Lopez, Maria Francesca De Pandis, Ute Gschwandtner, Lutfu Hanoglu, Claudio Del Percio, Gerhard Ransmayr, Raffaella Franciotti, Bahar Güntekin, Francesco Famà, Laura Vacca, Peter Fuhr, Raffaele Ferri, Fabrizia D'Antonio, Dag Aarsland, Carlo de Lena, Flavio Nobili, John-Paul Taylor, Roberta Lizio, Moira Marizzoni, Franco Giubilei, Fabrizio Stocchi, Virginia Cipollini, Giuseppe Noce, Lucilla Parnetti, Görsev Yener, Lucia Farotti, Claudio Babiloni, Antonio Ivano Triggiani, Andrea Soricelli, Marco Onofrj, Derya Durusu Emek-Savaş, Giovanni B. Frisoni, Marco Rizzo, and Maria Teresa Pascarelli
- Subjects
Male ,0301 basic medicine ,Aging ,Parkinson's disease ,Hallucinations ,Motor Disorders ,Audiology ,Electroencephalography ,Resting-State Electroencephalographic (Rseeg) Rhythms ,Visual Hallucinations ,0302 clinical medicine ,Cortical Synchronization ,media_common ,Exact Low-Resolution Brain Electromagnetic Source Tomography (Eloreta) ,medicine.diagnostic_test ,General Neuroscience ,Visual hallucinations ,Parkinson Disease ,Cognition ,Alpha Rhythm ,Female ,Wakefulness ,Alzheimer's disease ,Vigilance (psychology) ,medicine.medical_specialty ,Parkinson's disease (PD) ,media_common.quotation_subject ,Exact low-resolution brain electromagnetic source tomography (eLORETA) ,Mini-Mental State Evaluation (MMSE) ,Resting-state electroencephalographic (rsEEG) rhythms ,Unified Parkinson Disease Rating Scale-III (UPDRS III) ,Neuropathology ,03 medical and health sciences ,medicine ,Humans ,Cognitive Dysfunction ,Aged ,business.industry ,medicine.disease ,ddc:616.8 ,030104 developmental biology ,Neurology (clinical) ,Geriatrics and Gerontology ,business ,030217 neurology & neurosurgery ,Developmental Biology ,Parkinson's Disease (PD) - Abstract
Compared with Alzheimer's disease (AD), Parkinson's disease (PD) shows peculiar clinical manifestations related to vigilance (i.e., executive cognitive deficits and visual hallucinations) that may be reflected in resting-state electroencephalographic rhythms. To test this hypothesis, clinical and resting-state electroencephalographic rhythms in age-, sex-, and education-matched PD patients (N = 136) and Alzheimer's disease patients (AD, N = 85), and healthy older participants (Nold, N = 65), were available from an international archive. Electroencephalographic sources were estimated by eLORETA software. The results are as follows: (1) compared to the Nold participants, the AD and PD patients showed higher widespread delta source activities (PD > AD) and lower posterior alpha source activities (AD > PD); (2) the PD patients with the most pronounced motor deficits exhibited very low alpha source activities in widespread cortical regions; (3) the PD patients with the strongest cognitive deficits showed higher alpha source activities in widespread cortical regions; and (4) compared to the PD patients without visual hallucinations, those with visual hallucinations were characterized by higher posterior alpha sources activities. These results suggest that in PD patients resting in quiet wakefulness, abnormalities in cortical neural synchronization at alpha frequencies are differently related to cognitive, motor, and visual hallucinations. Interestingly, parallel PD neuropathological processes may have opposite effects on cortical neural synchronization mechanisms generating cortical alpha rhythms in quiet wakefulness. (C) 2020 Elsevier Inc. All rights reserved.
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- 2020
91. Phase and amplitude correlations change with disease progression in idiopathic rapid eye-movement sleep behavior disorder patients
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Dario Arnaldi, Matteo Pardini, Nicola Girtler, Francesco Famà, Andrea Donniaquio, Pietro Mattioli, Gabriele Arnulfo, Laura Giorgetti, Beatrice Orso, Flavio Nobili, Andrea Brugnolo, Monica Roascio, and Silvia Morbelli
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medicine.medical_specialty ,Behavior disorder ,Amplitude ,Neurology ,business.industry ,Internal medicine ,Disease progression ,Cardiology ,medicine ,Rapid eye movement sleep ,Phase (waves) ,Neurology (clinical) ,business - Published
- 2021
92. Twenty-four hours blood pressure profile in idiopathic REM sleep behavior disorder
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Laura Pilati, Ivana Sartori, Raffaele Manni, Valter Rustioni, Natascia Ghiotto, Maurizio Versino, Michele Terzaghi, and Dario Arnaldi
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Blood pressure ,Neurology ,business.industry ,Anesthesia ,medicine ,Neurology (clinical) ,medicine.disease ,business ,REM sleep behavior disorder - Published
- 2021
93. Hyperconnectivity in dementia is early and focal and vanishes with disease progression
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Laura Ferri, Giacomo Koch, Laura Bonanni, Annachiara Cagnin, Alberto Benussi, Raffaella Franciotti, Mirella Russo, Alessandro Padovani, Claudio Babiloni, Filomena Barbone, Marco Onofrj, Dario Arnaldi, Claudia Carrarini, Flavio Nobili, Barbara Borroni, and Davide V. Moretti
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Oncology ,medicine.medical_specialty ,Neurology ,business.industry ,Internal medicine ,Disease progression ,medicine ,Dementia ,Hyperconnectivity ,Neurology (clinical) ,business ,medicine.disease - Published
- 2021
94. Metabolic signature of hyposmia after mild COVID-19: An [18]F-FDG-pet study
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Cecilia Marini, Alberto Miceli, Matteo Pardini, Silvia Morbelli, Stefano Raffa, Isabella Donegani, Gianmario Sambuceti, Federico Massa, Flavio Nobili, Michele Pennone, Silvia Chiola, Dario Arnaldi, and Matteo Bauckneht
- Subjects
Neurology ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Hyposmia ,Medicine ,Neurology (clinical) ,medicine.symptom ,Signature (topology) ,business ,Nuclear medicine ,Article - Published
- 2021
95. Alzheimer's disease MRI patterns: Cognitive, structural and cerebrospinal fluid correlates
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Dario Arnaldi, Beatrice Orso, Matteo Pardini, Erica Biassoni, Flavio Nobili, Luca Roccatagliata, Andrea Donniaquio, Fabio Bandini, Stefano Grisanti, Pilar M. Ferraro, and Laura Filippi
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Pathology ,medicine.medical_specialty ,Cerebrospinal fluid ,Neurology ,business.industry ,Medicine ,Cognition ,Neurology (clinical) ,Disease ,business - Published
- 2021
96. Neuropsychological and brain metabolism characteristics of mild cognitive impairment in prodromal Alzheimer's disease and in prodromal synucleinopathy
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Matteo Pardini, Federico Massa, Pietro Mattioli, Laura Giorgetti, Andrea Brugnolo, Francesco Famà, Elisa Doglione, Silvia Morbelli, Beatrice Orso, Erica Biassoni, Flavio Nobili, Andrea Donniaquio, Nicola Girtler, Stefano Grisanti, Dario Arnaldi, and Matteo Bauckneht
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medicine.medical_specialty ,Neurology ,business.industry ,medicine ,Neuropsychology ,Neurology (clinical) ,Disease ,Audiology ,Cognitive impairment ,business - Published
- 2021
97. Cortical network modularity changes along the course of frontotemporal and Alzheimer's dementing diseases
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Filomena Barbone, Alessandro Padovani, Dario Arnaldi, Annachiara Cagnin, Laura Bonanni, Raffaella Franciotti, Laura Ferri, Ftd Italian study group-SINDEM, Marco Onofrj, Mirella Russo, Nicola Walter Falasca, Barbara Borroni, Alberto Benussi, Giacomo Koch, Flavio Nobili, Claudia Carrarini, Davide V. Moretti, and Claudio Babiloni
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Male ,Aging ,Time Factors ,Computer science ,Electroencephalography ,Functional connectivity ,Cognition ,Alzheimer Disease ,mental disorders ,medicine ,Alzheimer's dementia ,Frontotemporal dementia ,Graph theory ,Mutual information ,Resting state Electroencephalography ,Dementia ,Humans ,Aged ,Aged, 80 and over ,Modularity (networks) ,medicine.diagnostic_test ,business.industry ,General Neuroscience ,Prodromal Stage ,Middle Aged ,medicine.disease ,Frontal Lobe ,Neurology ,Cortical network ,Disease Progression ,Female ,Neurology (clinical) ,Geriatrics and Gerontology ,business ,Neuroscience ,Developmental Biology - Abstract
Cortical network modularity underpins cognitive functions, so we hypothesized its progressive derangement along the course of frontotemporal (FTD) and Alzheimer's (AD) dementing diseases. EEG was recorded in 18 FTD, 18 AD, and 20 healthy control s (HC). In the FTD and AD patients, the EEG recordings were performed at the prodromal stage of dementia, at the onset of dementia, and three years after the onset of dementia. HC underwent three EEG recordings at 2-3-year time interval. Information flows underlying EEG activity recorded at electrode pairs were estimated by means of Mutual Information (MI) analysis. The functional organization of the cortical network was modelled by means of the Graph theory analysis on MI adjacency matrices. Graph theory analysis showed that the main hub of HC (Parietal area) was lost in FTD patients at onset of dementia, substituted by provincial hubs in frontal leads. No changes in global network organization were found in AD. Despite a progressive cognitive impairment during the FTD and AD progression, only the FTD patients showed a derangement in the cortical network modularity, possibly due to dysfunctions in frontal functional connectivity.
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- 2021
98. Paraneoplastic limbic encephalitis with anti-MA2 antibodies: The value of early diagnosis and immunomodulatory treatment
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Flavio Villani, Stefano Grisanti, Dario Arnaldi, Luana Benedetti, Francesco Famà, Pietro Mattioli, Andrea Donniaquio, Erica Biassoni, Nicola Girtler, Laura Giorgetti, and Beatrice Orso
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Paraneoplastic limbic encephalitis ,Neurology ,biology ,business.industry ,Immunology ,biology.protein ,Medicine ,Neurology (clinical) ,Antibody ,business ,Value (mathematics) - Published
- 2021
99. Accuracy of FDG-PET at the individual level in MCI-LB versus MCI-AD: A stepwise approach from visual to semi-quantitative analysis
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Matteo Pardini, Andrea Brugnolo, Isabella Donegani, Beatrice Orso, Flavio Nobili, Marco Pagani, Erica Biassoni, Enrico Peira, Nicola Girtler, Matteo Bauckneht, Federico Massa, Ugo Paolo Guerra, Silvia Morbelli, Stefano Raffa, Dario Arnaldi, Andrea Chincarini, and Pietro Mattioli
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Neurology ,business.industry ,Medicine ,Neurology (clinical) ,Individual level ,Nuclear medicine ,business ,Semi quantitative ,Stepwise approach - Published
- 2021
100. The Alzheimer's disease metabolic brain pattern in mild cognitive impairment
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Sanne K. Meles, Klaus L. Leenders, Flavio Nobili, Fabrizio De Carli, Dario Arnaldi, Gianmario Sambuceti, Silvia Morbelli, Cathrine Jonsson, Marco Pagani, and Barbara Dessi
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Oncology ,Aging ,principal component analysis ,Disease ,Normal aging ,030218 nuclear medicine & medical imaging ,0302 clinical medicine ,PARKINSONS-DISEASE ,Medicine ,Cognitive impairment ,Brief Report ,DEMENTIA ,Brain ,Alzheimer's disease ,normal aging ,RESERVE ,Neurology ,Disease Progression ,DIFFERENTIAL-DIAGNOSIS ,Cardiology and Cardiovascular Medicine ,Alzheimer’s disease ,medicine.medical_specialty ,BIOMARKERS ,VALIDATION ,18f fdg pet ,18F-FDG-PET ,03 medical and health sciences ,mild cognitive impairment ,Alzheimer Disease ,Fluorodeoxyglucose F18 ,Internal medicine ,mental disorders ,Dementia ,Humans ,Cognitive Dysfunction ,PET DATA ,business.industry ,NETWORK ACTIVITY ,Disease progression ,medicine.disease ,Positron-Emission Tomography ,F-18-FDG-PET ,Neurology (clinical) ,Differential diagnosis ,Radiopharmaceuticals ,business ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
We investigated the expression of the Alzheimer’s disease-related metabolic brain pattern (ADRP) in 18F-FDG-PET scans of 44 controls, 27 patients with mild cognitive impairment (MCI) who did not convert to Alzheimer’s disease (AD) after five or more years of clinical follow-up, 95 MCI patients who did develop AD dementia on clinical follow-up, and 55 patients with mild-to-moderate AD. The ADRP showed good sensitivity (84%) and specificity (86%) for MCI-converters when compared to controls, but limited specificity when compared to MCI non-converters (66%). Assessment of 18F-FDG-PET scans on a case-by-case basis using the ADRP may be useful for quantifying disease progression.
- Published
- 2017
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