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Dopaminergic imaging and clinical predictors for phenoconversion of REM sleep behaviour disorder
- Source :
- Brain, Arnaldi, D, Chincarini, A, Hu, M T, Sonka, K, Boeve, B, Miyamoto, T, Puligheddu, M, De Cock, V C, Terzaghi, M, Plazzi, G, Tachibana, N, Morbelli, S, Rolinski, M, Dusek, P, Lowe, V, Miyamoto, M, Figorilli, M, de Verbizier, D, Bossert, I, Antelmi, E, Meli, R, Barber, T R, Trnka, J, Miyagawa, T, Serra, A, Pizza, F, Bauckneht, M, Bradley, K M, Zogala, D, McGowan, D R, Jordan, L, Manni, R & Nobili, F 2020, ' Dopaminergic imaging and clinical predictors for phenoconversion of REM sleep behaviour disorder ', Brain . https://doi.org/10.1093/brain/awaa365
- Publication Year :
- 2020
-
Abstract
- This is an international multicentre study aimed at evaluating the combined value of dopaminergic neuroimaging and clinical features in predicting future phenoconversion of idiopathic REM sleep behaviour (iRBD) subjects to overt synucleinopathy. Nine centres sent 123I-FP-CIT-SPECT data of 344 iRBD patients and 256 controls for centralized analysis. 123I-FP-CIT-SPECT images were semiquantified using DaTQUANTTM, obtaining putamen and caudate specific to non-displaceable binding ratios (SBRs). The following clinical variables were also analysed: (i) Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale, motor section score; (ii) Mini-Mental State Examination score; (iii) constipation; and (iv) hyposmia. Kaplan-Meier survival analysis was performed to estimate conversion risk. Hazard ratios for each variable were calculated with Cox regression. A generalized logistic regression model was applied to identify the best combination of risk factors. Bayesian classifier was used to identify the baseline features predicting phenoconversion to parkinsonism or dementia. After quality check of the data, 263 iRBD patients (67.6 ± 7.3 years, 229 males) and 243 control subjects (67.2 ± 10.1 years, 110 males) were analysed. Fifty-two (20%) patients developed a synucleinopathy after average follow-up of 2 years. The best combination of risk factors was putamen dopaminergic dysfunction of the most affected hemisphere on imaging, defined as the lower value between either putamina (P
- Subjects :
- Male
medicine.medical_specialty
Synucleinopathies
Unified Parkinson's disease rating scale
Kaplan-Meier Estimate
REM Sleep Behavior Disorder
Logistic regression
REM sleep behavior disorder
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Aged
Retrospective Studies
Tomography, Emission-Computed, Single-Photon
Dopamine Plasma Membrane Transport Proteins
Mini–Mental State Examination
medicine.diagnostic_test
Proportional hazards model
business.industry
Parkinsonism
Hazard ratio
Putamen
Original Articles
Middle Aged
medicine.disease
Confidence interval
REM sleep behaviour disorder
ROC Curve
SPECT
Parkinson’s disease
Female
Neurology (clinical)
dementia with Lewy bodies
Caudate Nucleus
business
030217 neurology & neurosurgery
Tropanes
Subjects
Details
- ISSN :
- 14602156
- Volume :
- 144
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Brain : a journal of neurology
- Accession number :
- edsair.doi.dedup.....fa361e64521f47fbb67f2f01134e0771