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619 results on '"Cristina Sanchez"'

55. Readout Firmware of the Vertex Locator for LHCb Run 3 and Beyond

Author

Mark Richard James Williams, Pawel Jalocha, Kurt Rinnert, Francesco Dettori, Pawel Kopciewicz, John Back, Malcolm John, Jan Buytaert, T. J. V. Bowcock, Timothy Gershon, Michael Joseph Morello, B. Rachwal, Nathan Jurik, Kristof De Bruyn, Karol Hennessy, Elena Dall' Occo, Jaap Velthuis, Andrew J. Morris, Victor Coco, Irina Nasteva, Federico Lazzari, Abraham Gallas Torreira, Maciej Witold Majewski, Pablo Vazquez Regueiro, Christopher Parkes, Daniel Hynds, Donal Murray, M. Ferro-Luzzi, Martin van Beuzekom, Timothy Evans, Stefano De Capua, Giovanni Punzi, Vladimir Volkov, Larissa Helena Mendes, Karlis Dreimanis, Deepanwita Dutta, Gabriel Rodrigues, Manuel Schiller, Antonio Fernandez Prieto, Igor Kostiuk, Lucas Meyer Garcia, Lars Eklund, Marcel Merk, Luke Scantlebury-Smead, Silvia Borghi, Edgar Lemos Cid, P. Collins, Peter Svihra, Galina Bogdanova, Aleksandra Snoch, Kazu Akiba, Tara Shears, Alexander Leflat, Oscar Augusto, Vinicius Franco Lima, Sneha Naik, Wouter Hulsbergen, Tomasz Szumlak, David Hutchcroft, Agnieszka Oblakowska-Mucha, Heinrich Schindler, Dana Bobulska, Juan Otalora, Franciole Da Cunha Marinho, Cristina Sanchez Graz, T. E. Latham, Beatriz Garcia Plana, Oscar Boente Garcia, Marco Gersabeck, Giovanni Bassi, Hennessy, Karol, Prieto, Antonio Fernandez, Regueiro, Pablo Vazquez, Buytaert, Jan, Van Beuzekom, Martin, Cid, Edgar Lemo, Eklund, Lar, de Bruyn, Kristof, Naik, Sneha, Schiller, Manuel, Murray, Donal, Leflat, Alexander, Bassi, Giovanni, Punzi, Giovanni, Lazzari, Federico, Morello, Michael J., Garcia, Oscar Boente, Torreira, Abraham Galla, Plana, Beatriz Garcia, Bowcock, Themi, Dettori, Francesco, Dreimanis, Karli, Lima, Vinicius Franco, Hutchcroft, David, Rinnert, Kurt, Shears, Tara, Augusto, Oscar, Coco, Victor, Collins, Paula, Evans, Tim, Ferro-Luzzi, Massi, Schindler, Heinrich, Akiba, Kazu, Occo, Elena Dall', Graz, Cristina Sanchez, Hulsbergen, Wouter, Hynds, Daniel, Kostiuk, Igor, Merk, Marcel, Snoch, Aleksandra, Bobulska, Dana Seman, Borghi, Silvia, de Capua, Stefano, Dutta, Deepanwita, Gersabeck, Marco, Parkes, Chri, Svihra, Peter, Williams, Mark, Bogdanova, Galina, Volkov, Vladimir, Kopciewicz, Pawel, Majewski, Maciej, Oblakowska-Mucha, Agnieszka, Rachwal, Bartlomej, Szumlak, Tomasz, Garcia, Lucas Meyer, Marinho, Franciole, Mendes, Larissa Helena, Nasteva, Irina, Otalora, Juan, Rodrigues, Gabriel, Velthuis, Jaap, Jalocha, Pawel, John, Malcolm, Jurik, Nathan, Scantlebury-Smead, Luke, Back, John, Gershon, Tim, Latham, Tom, and Morris, Andrew

Subjects
Nuclear and High Energy Physics, Large Hadron Collider, Computer science, Firmware, business.industry, Settore FIS/01 - Fisica Sperimentale, Detector, vertex locator (VELO), computer.software_genre, DAQ, Computing and Computers, LHCb, Data acquisition, firmware, Nuclear Energy and Engineering, Application-specific integrated circuit, Gigabit, readout, Detectors and Experimental Techniques, Electrical and Electronic Engineering, Serializer, business, Field-programmable gate array, computer, Computer hardware
Abstract

The new LHCb Vertex Locator (VELO) for LHCb, comprising a new pixel detector and readout electronics, will be installed in 2021 for data taking in Run 3 at the LHC. The electronics centers around the "VeloPix" ASIC at the front-end operating in a trigger-less readout at 40MHz. A custom serializer, called gigabit wireline transmitter (GWT), and associated custom protocol have been designed for the VeloPix. The GWT data are sent from the serializers of the VeloPix at a line rate of 5.12 Gb/s, reaching a total data rate of 2-3 Tb/s for the full VELO detector. Data are sent over 300-m optic-fiber links to the control and readout electronics cards for deserialization and processing in Intel Arria 10 FPGAs. Because of the VeloPix trigger-less design, latency variances up to 12 mu s can occur between adjacent datagrams. It is therefore essential to buffer and synchronize the data in firmware prior to onward propagation or suffer a huge CPU-processing penalty. This article will describe the architecture of the readout firmware in detail with focus given to the resynchronization mechanism and techniques for cauterization. Issues found during readout commissioning, and scaling resource utilization, along with the their solutions, will be illustrated. The latest results of the firmware data-processing chain can be presented as well as the verification procedures employed in simulation. Challenges for the next generation of the detector will also be presented with ideas for a readout processing solution. The new LHCb Vertex Locator (VELO) for LHCb, comprising a new pixel detector and readout electronics, will be installed in 2021 for data taking in Run 3 at the LHC. The electronics centers around the 'VeloPix' ASIC at the front-end operating in a trigger-less readout at 40MHz. A custom serializer, called gigabit wireline transmitter (GWT), and associated custom protocol have been designed for the VeloPix. The GWT data are sent from the serializers of the VeloPix at a line rate of 5.12 Gb/s, reaching a total data rate of 2-3 Tb/s for the full VELO detector. Data are sent over 300-m optic-fiber links to the control and readout electronics cards for deserialization and processing in Intel Arria 10 FPGAs. Because of the VeloPix trigger-less design, latency variances up to 12 $\mu \text{s}$ can occur between adjacent datagrams. It is therefore essential to buffer and synchronize the data in firmware prior to onward propagation or suffer a huge CPU-processing penalty. This article will describe the architecture of the readout firmware in detail with focus given to the resynchronization mechanism and techniques for cauterization. Issues found during readout commissioning, and scaling resource utilization, along with the their solutions, will be illustrated. The latest results of the firmware data-processing chain can be presented as well as the verification procedures employed in simulation. Challenges for the next generation of the detector will also be presented with ideas for a readout processing solution.

Published
2021

57. The presence of a large patent foramen ovale reduces acute and chronic success in atrial fibrillation ablation

Author

Maria Teresa Barrio-Lopez, Eduardo Castellanos, Andres Betancur, Blanca Zorita, Juan Medina, Nieves Losada, Maria Diaz del Valle, Cristina Sanchez, Rosa Crespo, Victor Gonzalez, Tamara Morales, Belen Urriza, Mercedes Ortiz, and Jesús Almendral

Subjects
Male, Treatment Outcome, Recurrence, Physiology (medical), Atrial Fibrillation, Catheter Ablation, Foramen Ovale, Patent, Humans, Female, Cardiology and Cardiovascular Medicine
Abstract

In this study, we analyzed PFO implications in atrial fibrillation (AF) ablation.Six hundred and twenty-five consecutive patients with AF undergoing PV isolation were included. We considered that a large and/or compliant PFO was present if the catheters advanced gently into the LA without puncturing the septum. Atrial tachyarrhythmias after the 3-month blanking period were classified as a recurrence.Out of the 625 patients included, 36 (5.8%) were found to have PFO. No significant differences were observed in the clinical characteristics of patients with PFO compared with patients without PFO. Nevertheless, patients with PFO had lower acute success in PV isolation compared with patients without PFO (98.2% vs. 88.5%; p = 0.006) even after adjusting for age, sex, type of AF, LA area, cardiomyopathy, time from AF diagnosis to the ablation, and ablation technique (odds ratio: 0.1; 95% confidence interval (CI): 0.02-0.9; p = 0.039). In 546 patients followed more than 6 months, the recurrence rate of any atrial tachyarrhythmia after 18.6 ± 11.9 months was significantly higher in patients with PFO compared with patients without PFO (41.9 vs. 70%; p = 0.012). This difference remained significant after adjusting for age, sex, type of AF, LA area, cardiomyopathy, time from AF diagnosis to the ablation, and ablation technique (hazard ratio: 1.9; 95% CI: 1.1-3.3; p = 0.015).The presence of a large and/or compliant PFO is an independent factor for PV isolation failure and arrhythmia recurrence rate after the ablation.

Published
2022

58. Patterns of Postoperative Trismus Following Mandibulectomy and Fibula Free Flap Reconstruction

Author

Rex H. Lee, Cara Evans, Joey Laus, Cristina Sanchez, Katherine C. Wai, P. Daniel Knott, Rahul Seth, Ivan H. El-Sayed, Jonathan R. George, William R. Ryan, Chase M. Heaton, Andrea M. Park, and Patrick K. Ha

Subjects
Cancer Research, Oncology, trismus, mouth opening, mandibulectomy, fibula free flap, postoperative, ramus, MIO, interincisal opening, head and neck, survivorship
Abstract

The factors that contribute to postoperative trismus after mandibulectomy and fibula free flap reconstruction (FFFR) are undefined. We retrospectively assessed postoperative trismus (defined as a maximum interincisal opening ≤35 mm) in 106 patients undergoing mandibulectomy with FFFR, employing logistic regression to identify risk factors associated with this sequela. The surgical indication was primary ablation in 64%, salvage for recurrence in 24%, and osteonecrosis in 12%. Forty-five percent of patients had existing preoperative trismus, and 58% of patients received adjuvant radiation/chemoradiation following surgery. The overall rates of postoperative trismus were 76% in the early postoperative period (≤3 months after surgery) and 67% in the late postoperative period (>6 months after surgery). Late postoperative trismus occurred more frequently in patients with ramus-involving vs. ramus-preserving posterior mandibulotomies (82% vs. 46%, p = 0.004). A ramus-involving mandibulotomy was the only variable significantly associated with trismus >6 months postoperatively on multivariable logistic regression (OR, 7.94; 95% CI, 1.85–33.97; p = 0.005). This work demonstrates that trismus is common after mandibulectomy and FFFR, and suggests that posterior mandibulotomies that involve or remove the ramus may predispose to a higher risk of persistent postoperative trismus.

Published
2023
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60. Dysfunctional serotonergic neuron-astrocyte signaling in depressive-like states

Author

Gertrudis Perea, Candela Gonzalez-Arias, Julio Esparza, Cristina Sanchez-Puelles, Lucia Arancibia, Andrea Sanchez-Ruiz, Jorge Ramirez-Franco, Davide Gobbo, and Frank Kirchhoff

Abstract

Astrocytes play crucial roles in brain homeostasis and are regulatory elements of neuronal and synaptic physiology. Astrocytic alterations have been found in Major Depressive Disorder (MDD) patients; however, the consequences of astrocyte Ca2+ signaling in MDD are poorly understood. Here, we found that corticosterone-treated mice (Cort-mice) showed altered astrocytic Ca2+ dynamics in mPFC both in resting conditions and during social interactions, in line with altered mice behavior. Additionally, Cort-mice displayed reduced serotonin (5-HT)-mediated Ca2+ signaling in mPFC astrocytes, and aberrant 5-HT-driven synaptic plasticity in layer 2/3 mPFC neurons. Downregulation of astrocyte Ca2+ signaling in naïve animals mimicked the synaptic deficits found in Cort-mice. Remarkably, boosting astrocyte Ca2+ signaling with Gq-DREADDS restored mood and cognitive deficits in Cort-mice to control levels. This study highlights the important role of astrocyte Ca2+ signaling for homeostatic control of brain circuits and behavior, but also reveals its potential therapeutic value for depressive-like states.

Published
2023

64. Rapid Analytical Method for the Quantification of Bromoform in the Red Seaweeds Asparagopsis armata and Asparagopsis taxiformis Using Gas Chromatography–Mass Spectrometry

Author

Katia Pes, Donato Romanazzi, Thomas T. Wheeler, Cristina Sanchez-Garcia, Johan Svenson, Colin M. Hayman, Leonardo Mata, and Marie Magnusson

Subjects
chemistry.chemical_compound, Chromatography, chemistry, biology, Asparagopsis armata, Plant Science, Asparagopsis taxiformis, Bromoform, Gas chromatography–mass spectrometry, biology.organism_classification, Agricultural and Biological Sciences (miscellaneous), Agronomy and Crop Science, Food Science
Published
2021

66. Aproximaciones al humanismo ignaciano

Author

Grajales, Diego Agudelo, Flórez, Tatiana Saavedra, Botero, Humberto Jaramillo, León, María Cristina Sánchez, Pérez, Hernán Darío Sarmiento, Cadena, Leonardo Rojas, López, Natalia María Ramírez, Romero, Ever Eduardo Velasco, Ramírez, Adriano Padilla, Giraldo, Ana María Giraldo, Ruiz, Víctor Martínez, Sarrias, Andrés Sandoval, Ospina, Jesús Carrasquilla, Grajales, Diego Agudelo, Flórez, Tatiana Saavedra, Botero, Humberto Jaramillo, León, María Cristina Sánchez, Pérez, Hernán Darío Sarmiento, Cadena, Leonardo Rojas, López, Natalia María Ramírez, Romero, Ever Eduardo Velasco, Ramírez, Adriano Padilla, Giraldo, Ana María Giraldo, Ruiz, Víctor Martínez, Sarrias, Andrés Sandoval, and Ospina, Jesús Carrasquilla

Published
2019
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68. Evidence of a J/ψΛ structure and observation of excited Ξ- states in the Ξb-→J/ψΛK- decay

Author

Sergey Legotin, Thomas Peter Jones, Andrea Lampis, Monica Pepe Altarelli, Sergii Kandybei, Eric Cogneras, Alexander Malinin, Mikhail Korolev, Naomi Cooke, Ross John Hunter, Eric van Herwijnen, Dmitry Golubkov, V. Matiunin, Mika Vesterinen, Z. Li, Stephane T'Jampens, S. Filippov, Stephanie Hansmann-Menzemer, Giacomo Graziani, J. A. B. Coelho, Lavinia-Helena Giubega, E. Golobardes, P. J. Marshall, D. Xiao, N. Polukhina, Placido Fernandez Declara, L. Minzoni, Ricardo Vazquez Gomez, David Anthony Friday, Harris Conan Bernstein, Cesar Luiz Da Silva, Jakob Haimberger, Halime Sazak, Vladimir Shevchenko, Maarten van Veghel, Irina Nasteva, George Coombs, Rosen Matev, Suzanne Klaver, Alexandre Boyer, Pablo Baladron Rodriguez, Abraham Gallas Torreira, Elisabeth Maria Niel, Sonia Amina Bouchiba, N. S. Nolte, V. Macko, J. Buytaert, Xianglei Zhu, Ilia Belov, Andreas Schopper, Melissa Maria Cruz Torres, T. Nanut, C. Bozzi, H. Viemann, Aleksandr Petrov, Antonio Falabella, Davide Zuliani, H. Stevens, Jonas Rademacker, Bo Fang, Kristof De Bruyn, F. Ferreira Rodrigues, S. Kotriakhova, Yuehong Xie, Anastasia Smetkina, Peilian Li, Maximo Plo Casasus, John Jake Lane, J. Wang, Marek Jezabek, Giovanni Passaleva, Thi Thuy Hang Pham, Di Yang, Eddy Jans, Roger Barlow, Cheryl Pappenheimer, Lais Soares Lavra, I. A. Monroy, Federico Stagni, Wojciech Kucewicz, S. Jakobsen, Jozef Tomasz Borsuk, Agnieszka Dziurda, Ricardo Graciani Diaz, Yury Guz, Regis Lefèvre, Lucian Cojocariu, Mark Smith, M. Soares, M. Hatch, S. Kretzschmar, Stephen M. Stahl, John Back, M. D. Sokoloff, Simone Bifani, Mark Whitehead, Lucas Mcconnell, Semen Eidelman, A. Usachov, Silvia Borghi, Pavel Krokovny, Mario Edgardo Olivares, Rui Wang, Christopher James Pawley, Lukas Calefice, A. Inglessi, Jose Maria Fernandez-tenllado Arribas, Aleksei Chernov, Davide Fazzini, Stephen Wotton, B. Delaney, S. Meloni, Zakariya Aliouche, M. S. Bieker, G. Morello, Richard Jacobsson, Marta Calvi, Giulia Manca, R. D. Moise, C. Hasse, Ekaterina Trifonova, W. Parker, Valerie Gibson, Patrizia De Simone, Shuaiyi Liu, Marie-Noelle Minard, Clara Gaspar, Massimiliano Fiorini, Miriam Calvo Gomez, Carla Marin Benito, Evgeny Gushchin, Ilaria Neri, Oliver Lupton, W. Huang, Stefano De Capua, Nigel Watson, Alexey Zhelezov, Elena Graverini, B.R. Gruberg Cazon, Amanda May Donohoe, Valeriia Lukashenko, Jean François Marchand, Boleslaw Pietrzyk, Anna Lupato, Carlos Abellán Beteta, Konstantin Belous, Marco Poli Lener, B. Spaan, Daniel Patrick O'Hanlon, Giacomo Vitali, Marco Santimaria, Daniel Decamp, Jairo Alexis Rodriguez Lopez, S. Ponce, Lucio Anderlini, Oscar De Aguiar Francisco, U. Marconi, C. Weisser, S. Tolk, Valery Zhukov, Konrad Klimaszewski, Eliane Epple, Louis Lenard Gerken, S. Ek-In, Adriano Lai, A. Guth, Yutong Li, G. Liu, Miriam Gandelman, S. Monteil, Frederic Teubert, Christopher Burr, Dario de Simone, Michael Schmelling, Paul Andre Günther, J. B. Zonneveld, R. Calabrese, Oleg Stenyakin, A. Szabelski, Anna Danilina, Jakub Ryzka, Timothy Evans, George Lafferty, Marcelo Soares, Patrick Koppenburg, Artur Ukleja, Jose Lopes, Jakub Moron, X. Lyu, Carmen Giugliano, A. Maevskiy, Paolo Gandini, Marcello Rotondo, D. Zhang, Manuel Schiller, Marcos Romero Lamas, S. Schulte, P. Ibis, W. Krupa, S. Cadeddu, Lei Zhang, Simon Stemmle, Katharina Müller, P. Stefko, Philipp Roloff, Pere Gironella Gironell, J. S. Butter, M. Marinangeli, Michael Williams, Tatiana Gaintseva, Lorena Dieste Maronas, I. Williams, Anton Philippov, O. Schneider, Rudolf Oldeman, Roman Litvinov, Roel Aaij, Vadym Denysenko, Vasily Kudryavtsev, C. H. Murphy, Christopher Parkes, N. I. Voropaev, Jialu Wang, Felipe Luan Souza De Almeida, P. Spradlin, Francesca Dordei, A. Carbone, Jan Maratas, Jakub Jacek Malczewski, C. Gu, S. Bhasin, A. Camboni, O. Kot, Yipeng Sun, Iaroslava Bezshyiko, Ivan Shchemerov, Edoardo Franzoso, T. Ovsiannikova, Arnaud Robert, Thomas Latham, C. Patrignani, I. Carli, Julian Alexander Boelhauve, P. Collins, F. Pisani, F. Ferrari, K. R. Mattioli, V. Belavin, Murdo Traill, Alessandro Bertolin, D. Gerick, M. W. Slater, Sevda Esen, Ulrik Egede, L. Sun, Andrey Ustyuzhanin, T. Maltsev, Sajan Easo, Bernardo Adeva, Cibran Santamarina Rios, A. Dendek, Svende Braun, Diego Martinez Santos, Alessandro Petrolini, G. J. Kunde, S. Zhang, Danila Saranin, J. G. Smeaton, Marco Adinolfi, Adlène Hicheur, Benedict Donald C Westhenry, Stefania Ricciardi, Jifeng Hu, A. Merli, V. Tisserand, P. Gorbounov, T. Pajero, Karol Hennessy, Nikolay Nikitin, Marie Bachmayer, Alexandru Grecu, Thomas Ackernley, Marco Pappagallo, F. Redi, J. Hu, H. Li, K. Rinnert, Francesco Dettori, Adam Benjamin Morris, Jacopo Cerasoli, Gary Robertson, Sergey Gromov, Adam Davis, V. Pugatch, M. Hilton, Miguel Ramos Pernas, M. Féo, C. A. Aidala, Gaia Lanfranchi, Lex Marinus Greeven, Bhagyashree Pagare, Guy Wilkinson, Louis Henry, R. Calladine, Hilbrand Steffen Kuindersma, Marianna Fontana, C. M. Costa Sobral, D. Brundu, Niels Tuning, L. E. Yeomans, Luciano Pappalardo, D. Lancierini, M. Mulder, H. Cai, Paul Seyfert, C. Chen, Stefan Schael, Olivier Leroy, Yilong Wang, A. Venkateswaran, Arthur Marius Hennequin, Alessio Piucci, E. Santovetti, Yasmine Amhis, M. Atzeni, E. Grauges, Conor Fitzpatrick, Maxim Borisyak, Philippe d'Argent, X. Liang, Nuria Valls Canudas, A. Vorobyev, Dorothea Vom Bruch, Huanhuan Liu, Kristian Alexander Zarebski, Mariusz Witek, Mark Tobin, Michael Alexander, Renato Quagliani, Dmitrii Ilin, Q. Xu, Yongsheng Gao, Yanting Fan, Aleksei Andreianov, Harry Cliff, Wander Baldini, Victor Renaudin, Iain Longstaff, Anthony Gavin Downes, Julien Cogan, Bruno Souza De Paula, Jing Wang, Kenenbek Arzymatov, Adrian Casais Vidal, Dmitry Popov, G. Cavallero, Simon Akar, Matteo Giovannetti, V. Romanovskiy, Philippe Charpentier, Tomasz Fiutowski, Patrick Robbe, Robert Currie, Federico Alessio, Minh Tâm Tran, Christoph Frei, B. Quintana, Rainer Schwemmer, Pietro Marino, M. S. Rangel, Joel Closier, Matthew Birch, Kayleigh Anne Thomson, G. Panshin, Daniele Manuzzi, H. Malygina, J. L. Cobbledick, Abbie Jane Chadwick, B. Audurier, E. Maurice, T. Lesiak, F. Fleuret, I. Kostiuk, T. Mombächer, A. Bay, Sandra Amato, J. D. Roth, P. Campana, Victor Egorychev, Mikhail Shapkin, U. Uwer, Jinlin Fu, Jolanta Brodzicka, Biljana Mitreska, Alexey Dzyuba, K. Heijhoff, Y. Zhang, Yang Li, J. Qin, Gerwin Meier, Alex Pearce, Serena Maccolini, Jörg Marks, C. A. Chavez Barajas, Maria Vieites Diaz, Andrea Contu, A. Rollings, Xiaokang Zhou, Viacheslav Duk, Clara Remon Alepuz, Marcin Chrzaszcz, J. Plews, A. Ossowska, Liliana Congedo, Antonio Romero Vidal, Pascal Perret, G. Tuci, Abhijit Mathad, Z. Ren, A. Loi, Tomasz Skwarnicki, Sebastian Bachmann, Andrew George Morris, Polina Kravchenko, Thomas Ruf, A. Xu, M. Poliakova, Antonio Fernandez Prieto, Ivan Belyaev, Jan-Marc Basels, A. Artamonov, F. Reiss, Alexey Boldyrev, Artem Ryzhikov, Franz Muheim, G. H. Lovell, H. Dijkstra, M. Martinelli, Mark Richard James Williams, Flavio Fontanelli, Mikhail Zavertyaev, G. Raven, Alexander Bondar, Miroslaw Firlej, E. Shmanin, A. Kondybayeva, Juan Martin Otalora Goicochea, Laurent Dufour, V. Coco, Wouter Hulsbergen, Shuangli Yang, Zhihong Shen, Niladribihari Sahoo, Roger Forty, Frederic Machefert, Sheldon Stone, Domenico Galli, Lingzhu Bian, N. Serra, Darya Savrina, Paras Naik, Zoltan Mathe, Xiaoxue Han, Pablo Vazquez Regueiro, Nicola Neri, P. Ciambrone, Alison Tully, Michal Kreps, S. Poslavskii, G. Alkhazov, C. Meaux, Wojciech Wislicki, Mikhail Hushchyn, Sergey Strokov, Marco Guarise, V. Chobanova, C. Betancourt, Federico Lazzari, D. Murray, Marie Helene Schune, Q. Han, Paolo Carniti, E. Govorkova, M. Xu, Clara Matteuzzi, Quentin Fuehring, J. V. Mead, P. Mackowiak, Claire Prouve, Neville Harnew, Robbert Erik Geertsema, Eduard Ursov, Evelina Gersabeck, Barbara Passalacqua, Stefania Vecchi, Edward Brendan Shields, Angel Fernando Campoverde Quezada, Nicola Skidmore, Leonid Kravchuk, Maik Becker, Ettore Zaffaroni, Vasyl Dobishuk, Themistocles Bowcock, Gabriele Simi, Lukas Witola, Alberto Lusiani, A. Kharisova, Preema Rennee Pais, Biplab Dey, Lino Ferreira Lopes, Joan Ruiz Vidal, Miriam Lucio Martinez, N. Meinert, J. J. Walsh, Xuhao Yuan, D. Hynds, Francesco Polci, Michal Kazimierz Mazurek, M. Brodski, Z. Yang, Antonio Pellegrino, Kazuyoshi Carvalho Akiba, Matteo Rama, E. Dall'Occo, Sara Elizabeth Mitchell, Jan Langer, Eduardo Rodrigues, Michal Dziewiecki, Ana Barbara Rodrigues, Paula Garcia Moreno, Manuel Franco Sevilla, M. McCann, R. Kopecna, D. Gerstel, F. Keizer, A. Gomes, Federico Betti, P. Billoir, Yu Zhang, Maria Aranzazu Oyanguren, Sergio Gomez Fernandez, Jussara De Miranda, Phoebe Meredith Hamilton, G. Wormser, Vladimir Chulikov, Alexander Berezhnoy, Lakshan Ram Madhan Mohan, V. Obraztsov, Yue Pan, J. Heuel, J. Bhom, T. H. Hancock, V. Balagura, Denis Derkach, Erica Polycarpo, Rafael Silva Coutinho, Resmi Pk, M. Szymanski, Peter Griffith, Fergus Wilson, Elie Aslanides, Maciej Wojciech Dudek, Eric Thomas, S. Eisenhardt, Burkhard Schmidt, A. Chubykin, Adalberto Sciubba, Mitesh Patel, J. M. Durham, S. Nieswand, G. J. Pomery, Tatsuya Nakada, Olaf Steinkamp, G. Chatzikonstantinidis, Sergei Popov, C. D'Ambrosio, M. W. Majewski, M. Zeng, Yangheng Zheng, G. Bencivenni, M. S. Rudolph, Arnau Brossa Gonzalo, M. Schellenberg, Paula Alvarez Cartelle, T. Kirn, D. Wiedner, Sook Hyun Lee, Marco Clemencic, L. Martinazzoli, Daniel Charles Craik, Anatoliy Dovbnya, Artur Ishteev, Cameron Thomas Dean, M. Gersabeck, A. Vagner, F. Baryshnikov, Maria Flavia Cicala, K. Heinicke, D. Bobulska, Benjamin Couturier, Mateusz Goncerz, Alberto dos Reis, Milosz Zdybal, G. Pietrzyk, Stephen Farry, S. Escher, Michel De Cian, V. S. Kirsebom, Silvia Ferreres Sole, Antonios Papanestis, Alessandro Cardini, Maarten Van Dijk, Jibo He, H. M. Wark, Paul Nathaniel Swallow, Silvia Gambetta, Timothy Gershon, Youen Kang, S. Blusk, Daniel Vieira, Saverio Mariani, Vukan Jevtic, Tara Shears, Vitaly Vorobyev, Basem Khanji, D. Marangotto, Thomas Blake, Chishuai Wang, Marek Idzik, Lars Eklund, M. Materok, Anton Poluektov, Lorenzo Sestini, Achim Vollhardt, M. G. Chapman, Rafel Manera Escalero, Leon David Carus, Ziad Ajaltouni, Dominik Stefan Mitzel, Barbara Sciascia, Liliet Calero Diaz, Guillermo Loustau, Thomas Hadavizadeh, Raymond Mountain, Markus Frank, Donal Hill, Scott Ely, Beatriz Garcia Plana, Gianluca Zunica, Alexander Leflat, Chung Nguyen-Mau, Karlis Dreimanis, Sophie Elizabeth Hollitt, Raja Nandakumar, Claudio Gotti, S. Aiola, Oscar Boente Garcia, Sebastian Neubert, Hossein Afsharnia, Dominik Müller, Daniel Lacarrere, Julian Lomba Castro, P. E. L. Clarke, David Websdale, Giulia Frau, Lishuang Ma, F. Archilli, Alexander Semennikov, W. Hu, Thomas Grammatico, S. Koliiev, Peter Svihra, S. Simone, Gregory Ciezarek, M. Veronesi, E. Gabriel, J. Sun, A. Beiter, Olivier Deschamps, Lei Li, Laura Promberger, Luis Alberto Granado Cardoso, Cynthia Nunez, Vinicius Franco Lima, Sergei Kholodenko, A. Konoplyannikov, Giuseppe Martellotti, B. Malecki, Wojciech Krzemien, Alessio Sarti, Thierry Gys, Alexandre Brea Rodriguez, Jeremy Dalseno, Oleksandr Zenaiev, Eleonora Luppi, Albert Bursche, L. Douglas, Donatella Lucchesi, Marilisa De Serio, Liupan An, M. E. Stramaglia, S. Maddrell-Mander, Petr Fedin, B. Batsukh, M. Bjørn, Carla Göbel, S. Cali, Sneha Malde, William Barter, Andrey Golutvin, F. Blanc, Jaap Velthuis, I. V. Gorelov, Giovanni Bassi, Lucas Meyer Garcia, T. Harrison, Yu Lu, K. Wyllie, Mikhail Mikhasenko, Andrea Bizzeti, Youhua Yang, Vincenzo Vagnoni, Giovanni Carboni, Mauro Piccini, A. Valassi, Piera Muzzetto, Luke George Scantlebury Smead, Jonas Nathanael Eschle, Guido Haefeli, Z. Xiang, Zhenzi Wang, Xabier Cid Vidal, Dylan Jaide White, Michela Garau, Marko Milovanovic, Christopher Jones, Naylya Sagidova, A. Alfonso Albero, B. Rachwal, Claudia Bertella, E. Ben-Haim, M. P. Blago, Kamil Leszek Fischer, Aleksandra Snoch, M. Wang, Paolo Durante, Maitreyee Mukherjee, Luis Miguel Garcia Martin, Ignacio Bediaga, Desmond Mzamo Shangase, Kyung Eun Kim, Martino Borsato, Lev Shekhtman, Carina Trippl, Lucia Grillo, Aleksandr Solovev, Xuesong Liu, Tabitha Halewood-leagas, J. P. Grabowski, Jingzhou Fan, H. Mu, Nikolay Bondar, Roland Bernet, Paul Soler, Marcel Merk, Massimiliano Ferro-Luzzi, Fidan Suljik, Sara Celani, Leandro De Paula, Tjeerd Ketel, Niko Neufeld, V. Placinta, Juan Mauricio, N. V. Raab, Emilie Bertholet, S. Petrucci, S. Zucchelli, Evangelos Leonidas Gkougkousis, Y. Yao, Zhihao Xu, Tengiz Kvaratskheliya, Cristina Sanchez Gras, Daniel Johnson, A. Gioventù, Tamaki Holly Mcgrath, D. Melnychuk, P. Kopciewicz, K. Petridis, Beat Jost, Marco Cattaneo, Agnieszka Oblakowska-Mucha, F. Kress, Stefan-Gabriel Chitic, Joseph David Shupperd, Felipe Andres Garcia Rosales, André Massafferri, A. Mauri, Oleg Maev, Luigi Del Buono, L. Xu, Martina Ferrillo, Matthew Needham, Carlos Vázquez Sierra, Giovanni Punzi, R. Newcombe, A. Battig, L. Shchutska, Eluned Smith, D. Pereima, A. Mödden, Ronan McNulty, Shantam Taneja, Matthew Kenzie, Zehua Xu, Daria Strekalina, Fionn Caitlin Ros Bishop, Juan Baptista Leite, K. Prasanth, Juan Jose Saborido Silva, Celestina Satriano, A. Seuthe, Thi Dung Nguyen, Krzysztof Swientek, Matthew James Tilley, Xavier Vilasis-Cardona, Nathanael Farley, F. Jiang, Tai-Hua Lin, Marina Artuso, Olga Madejczyk, D. Maisuzenko, Simone Capelli, Y. Luo, Ouail Kitouni, Johannes Albrecht, Malcolm John, Brian Meadows, Sophie Baker, F. Bedeschi, Roberta Cardinale, Roberta Santacesaria, Charlotte Barbara Van Hulse, I. Polyakov, Matthias Karacson, Xiaotao Huang, Elisabetta Spadaro Norella, Mark Wilkinson, Roland Waldi, B. G. Siddi, Oleg Yushchenko, Heinrich Schindler, Matthew Charles, Maksim Karpov, M. J. Bradley, Nathan Jurik, Zishuo Yang, Jianqiao Wang, Julián García Pardiñas, Biagio Saitta, H. Yin, Stanislav Luchuk, Mihai Straticiuc, S. Didenko, Gerco Onderwater, Christoph Langenbruch, Gianluigi Casse, D. Dutta, K. Ivshin, Daniel Joachim Unverzagt, W. Byczynski, Sara Sellam, Diego Alejandro Milanes, M. Andreotti, Sergey Barsuk, Ruiting Ma, T. Colombo, Oliver Lantwin, K. Gizdov, A. Sergi, G. Sarpis, Richard Lane, William Dean, Serhii Cholak, Andrew McNab, Pasquale Di Nezza, Giovanni Valenti, Davide Pinci, Patrick Owen, Michael Joseph Morello, Giampiero Mancinelli, M. Hecker, Vladimir Gligorov, M. Pili, Mauro Morandin, S. Belin, Philippe Ghez, W. Funk, Guanghua Gong, Hangyi Wu, Christopher John Parkinson, Lluis Garrido, Jennifer Clare Smallwood, Anatoly Butkevich, Minaugas Sarpis, Fernando Martinez Vidal, David Sanchez Gonzalo, Patricia Camargo Magalhaes, Michele Veltri, Alessia Satta, Sai-Juan Chen, Fedor Ratnikov, Marcin Kucharczyk, Florin Maciuc, Marco Petruzzo, Jacco de Vries, Maximilien Chefdeville, Luca Tomassetti, Marian Stahl, Jana Crkovská, A. Buonaura, F. Desse, Philip Ilten, Gloria Corti, V. Bellee, Rolf Lindner, Y. Gan, Stefano Perazzini, H.-P. Dembinski, Ivan Solovyev, Blake Leverington, D. Y. Tou, Fernanda Goncalves Abrantes, B. K. Jashal, V. Lisovskyi, Christophe Haen, Martinus van Beuzekom, E. Millard, Pascal Vincent, Lorenzo Capriotti, Nikita Kazeev, Jingyi Xu, Steffen Georg Weber, Rizwaan Adeeb Mohammed, A. Jawahery, Diego Torres Machado, H. Pullen, Renaud Le Gac, Jie Yu, Matteo Palutan, A. Pastore, Thomas Boettcher, M. Bartolini, R. A. Fini, Roberto Ribatti, A. Ene, Lorenzo Pica, A. Palano, Tomasz Szumlak, D. Berninghoff, Y. Zhou, M. Schubiger, Rafal Dominik Krawczyk, David Hutchcroft, R. I. Rabadan Trejo, Eva Vilella Figueras, M. Reboud, M. Saur, Igor Skiba, and Wenbin Qian

Subjects
Physics, Quantum chromodynamics, Particle physics, Multidisciplinary, Strangeness, 010502 geochemistry & geophysics, Quarkonium, Lambda, 01 natural sciences, Pentaquark, Luminosity, Excited state, High Energy Physics::Experiment, Invariant mass, 0105 earth and related environmental sciences
Abstract

First evidence of a structure in the $J/\psi{\Lambda}$ invariant mass distribution is obtained from an amplitude analysis of$\Xi_b^-{\rightarrow}J/\psi{\Lambda}K^-$ decays. The observed structure is consistent with being due to a charmonium pentaquark with strangeness with a significance of $3.1\sigma$ including systematic uncertainties and look-elsewhere effect. Its mass and width are determined to be $4458.8\pm2.9^{+4.7}_{-1.1}$ MeV and $17.3\pm6.5^{+8.0}_{-5.7}$ MeV, respectively, where the quoted uncertainties are statistical and systematic. The structure is also consistent with being due to two resonances. In addition, the narrow excited $\Xi^-$ states, $\Xi(1690)^-$ and $\Xi(1820)^-$, are seen for the first time in a $\Xi^-_b$ decay, and their masses and widths are measured with improved precision. The analysis is performed using $pp$ collision data corresponding to a total integrated luminosity of 9 fb$^{-1}$, collected with the LHCb experiment at centre-of-mass energies of 7, 8 and 13 TeV.

Published
2021

69. Cr, Ni, and Zn removal from landfill leachate using vertical flow wetlands planted with Typha domingensis and Canna indica

Author

Nahuel Ernesto Camaño Silvestrini, Gabriela Cristina Sanchez, Marcelo Abel Campagnoli, H. R. Hadad, Emanuel Nocetti, and Maria Alejandra Maine

Subjects
0106 biological sciences, Typha domingensis, biology, Chemical oxygen demand, chemistry.chemical_element, Plant Science, Zinc, 010501 environmental sciences, biology.organism_classification, 01 natural sciences, Pollution, Macrophyte, Chromium, chemistry, Wastewater, Environmental chemistry, Environmental Chemistry, Leachate, Canna indica, 010606 plant biology & botany, 0105 earth and related environmental sciences
Abstract

Chromium (Cr), Nickel (Ni), and zinc (Zn) removal from landfill leachate using mesocosm-scale vertical flow wetlands, the effect of recirculation, and the ability of macrophytes to retain metals were evaluated. Wetlands were filled with coarse sand and light expanded clay aggregates and planted with Typha domingensis or Canna indica. Wetlands were operated using intermittent loading, with and without recirculation. Raw leachate was diluted and spiked with metals to reach the following concentrations: 0.2 mg L-1 Cr , 0.2 mg L-1 Ni, and0.2 mg L-1 Zn and 1.0 mg L-1 Cr, 1.0 mg L-1 Ni, and 1.0 mg L-1 Zn. Wetlands planted with T. domingensis presented higher metal removal than those planted with C. indica. Recirculation enhanced metal removal efficiencies significantly, being for T. domingensis/C. indica: 60/54, 49/47, 61/47% for Cr, Ni, and Zn at 0.2 mg L-1, and 80/71, 76/62, 73/59% for Cr, Ni, and Zn at 1.0 mg L-1, respectively. Metals were efficiently retained by macrophytes. Plant biomass and metal concentrations in roots were significantly higher than in shoots. Scanning electron microscopy and X-ray microanalysis showed that metals were absorbed by internal root tissues. A hybrid wetland planted with T. domingensis may be implemented to improve not only metal but also chemical oxygen demand and total nitrogen removals.

Published
2021

70. TREINAMENTO RESISTIDO PARA PESSOAS COM DEFICIÊNCIA FÍSICA: QUALIDADE DE VIDA, AUTONOMIA E INDEPENDÊNCIA

Author

Everton Luiz de Olveira, Gabrielle Cristina Sanchez, Maicon Henrique Alves, and Claudia Teixeira Arroyo

Subjects
Psychic, Gerontology, Data collection, Quality of life, Perception, media_common.quotation_subject, Significant difference, Realm, Physical exercise, General Medicine, Psychology, Health quality, media_common
Abstract

Este estudo teve por objetivo elaborar e aplicar um programa de treinamento resistido para pessoas com deficiência física e verificar o efeito desse programa na autonomia funcional, bem como na percepção da qualidade de vida. Participaram desse estudo seis pessoas com lesão medular, enquadrados em uma faixa etária entre 24 e 56 anos, de ambos os sexos, em uma cidade do interior de São Paulo. Os instrumentos utilizados para a coleta dos dados foram a bateria de testes de Kawanishi; Greguol (2014) e o Questionário de Qualidade de Vida (WHOQOL-BREF). Os resultados mostraram uma significativa diferença entre o pré- e o pós-teste do questionário, na medida em que nos quatro domínios analisados (físico, psíquico, social e ambiental) pode-se detectar uma percepção positiva sobre a qualidade de vida após o engajamento em um programa de treinamento resistido. A média do domínio físico que, a priori, era de 56%, subiu para 79,8%; já no domínio psíquico foi de 68,8% para 88,9%; no domínio social foi de 63,9 para 80,6 e no domínio ambiental de 61,1 para 91,6. A qualidade de vida geral avançou de 66,7 para 91,7 e a qualidade de vida em saúde foi de 66,7 a 87,5. Quanto aos testes funcionais, não foi possível identificar mudanças estatisticamente significativas. Conclui-se, assim, que a prática de exercícios físicos, especificamente o treinamento resistido, pode favorecer a melhora da percepção da qualidade de vida de pessoas com deficiência física. Recebido em: 06/07/2020 Reformulado em: 12/01/2021 Aceito em: 12/01/2021

Published
2021

71. La utilidad metodológica de Wooclap: un estudio sobre la motivación y participación estudiantil universitaria

Author

Gloria Soto Martínez, Cristina Sánchez-López, and Helena-Fuensanta Martínez-Saura

Subjects
tecnologías educativas, enseñanza universitaria, herramientas digitales, metodologías activas, gamificación en educación, satisfacción, Education
Abstract

Actualmente, existen evidencias científicas de que el uso de las herramientas tecnológicas incrementa la motivación de los estudiantes ante la tarea a desarrollar, mostrando mayor interés hacia las mismas. Por lo que este estudio parte de la necesidad de encontrar recursos para captar y motivar al estudiantado en su proceso de enseñanza-aprendizaje. Para ello, el objetivo del trabajo fue analizar desde el punto de vista de los estudiantes el grado de empleabilidad (utilidad, interés y motivación) de la herramienta Wooclap en un contexto de educación universitaria según el sexo, la edad y la titulación de los estudiantes. Se realizó un estudio cuantitativo, con una muestra de 275 estudiantes universitarios de los Grados de Educación Infantil (EI), Educación Primaria (EP), Educación Social (ES), Doble Grado de Maestro en Educación Infantil y Primaria (PCEO_IyP), Doble Título con Itinerario Específico de Grado en Educación Primaria con Mención en Educación Física y Grado en Ciencias de la Actividad Física y del Deporte (PCEO_PyEF) y Educación Social (ES). Empleando un cuestionario de 15 ítems realizado a través de la plataforma Google Form, diseñado para valorar los diferentes campos sobre la empleabilidad de la herramienta digital Wooclap. Los resultados ponen de manifiesto que las estudiantes mujeres, que los estudiantes más jóvenes y que los pertenecientes a la Programación conjunta de estudios oficiales de Educación Infantil y Primaria valoran más positivamente la utilidad de la herramienta Wooclap. En conclusión, estos hallazgos resaltan la necesidad de incorporar este tipo de recursos tecnológicos en el proceso de enseñanza-aprendizaje en el ámbito universitario.

Published
2024
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72. A robust clustering strategy for stratification unveils unique patient subgroups in acutely decompensated cirrhosis

Author

Sara Palomino-Echeverria, Estefania Huergo, Asier Ortega-Legarreta, Eva M. Uson Raposo, Ferran Aguilar, Carlos de la Peña-Ramirez, Cristina López-Vicario, Carlo Alessandria, Wim Laleman, Alberto Queiroz Farias, Richard Moreau, Javier Fernandez, Vicente Arroyo, Paolo Caraceni, Vincenzo Lagani, Cristina Sánchez-Garrido, Joan Clària, Jesper Tegner, Jonel Trebicka, Narsis A. Kiani, Nuria Planell, Pierre-Emmanuel Rautou, and David Gomez-Cabrero

Subjects
Stratification, Clustering, Complex diseases, Cirrhosis, ACLF, Patient heterogeneity, Medicine
Abstract

Abstract Background Patient heterogeneity poses significant challenges for managing individuals and designing clinical trials, especially in complex diseases. Existing classifications rely on outcome-predicting scores, potentially overlooking crucial elements contributing to heterogeneity without necessarily impacting prognosis. Methods To address patient heterogeneity, we developed ClustALL, a computational pipeline that simultaneously faces diverse clinical data challenges like mixed types, missing values, and collinearity. ClustALL enables the unsupervised identification of patient stratifications while filtering for stratifications that are robust against minor variations in the population (population-based) and against limited adjustments in the algorithm’s parameters (parameter-based). Results Applied to a European cohort of patients with acutely decompensated cirrhosis (n = 766), ClustALL identified five robust stratifications, using only data at hospital admission. All stratifications included markers of impaired liver function and number of organ dysfunction or failure, and most included precipitating events. When focusing on one of these stratifications, patients were categorized into three clusters characterized by typical clinical features; notably, the 3-cluster stratification showed a prognostic value. Re-assessment of patient stratification during follow-up delineated patients’ outcomes, with further improvement of the prognostic value of the stratification. We validated these findings in an independent prospective multicentre cohort of patients from Latin America (n = 580). Conclusions By applying ClustALL to patients with acutely decompensated cirrhosis, we identified three patient clusters. Following these clusters over time offers insights that could guide future clinical trial design. ClustALL is a novel and robust stratification method capable of addressing the multiple challenges of patient stratification in most complex diseases.

Published
2024
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74. Perfil funcional básico de los jóvenes del programa nacional de tecnificación en bádminton

Author

María Isabel Gil-López, Cristina Sanchez-De la vieja, and Raquel Hernández-García

Subjects
Straight leg raise, medicine.medical_specialty, medicine.diagnostic_test, biology, Athletes, Total compensation, Core stability, Squat, 030229 sport sciences, biology.organism_classification, Shoulder flexion, Test (assessment), 03 medical and health sciences, 0302 clinical medicine, medicine, Physical therapy, 030212 general & internal medicine, Psychology
Abstract

El objetivo del presente estudio fue analizar el perfil funcional de un grupo de jóvenes deportistas, todos pertenecientes al programa nacional de tecnificación de bádminton. Se evaluaron a 43 jugadores de bádminton (26 chicos y 17 chicas), de entre 15 y 16 años, con una experiencia mínima de 3 años de práctica competitiva. Se evaluaron los patrones motores básicos utilizando para ello, la batería de valoración funcional “Basic Functional Assessment” compuesta por cinco pruebas funcionales Overhead Squat test (OHS), Hurdle Step (HS), Forward Step Down (FSD), Shoulder Mobility (SM) y Active Straight Leg Raise (ASLR). Los resultados muestran que el grupo de chicos ha presentado una mayor incidencia de compensaciones totales que el grupo de chicas. La compensación que más se ha repetido en toda la muestra ha sido la protracción cervical, vista en la prueba del SM. Seguida de la pérdida de flexión de hombros, en el test OHS. No se hallaron diferencias estadísticamente significativas entre géneros. De manera conjunta como equipo de bádminton sin diferenciación de género obtuvieron una media de 20,86 compensaciones sobre 75, mostrando un perfil funcional aceptable. Las compensaciones que más han presentado los jugadores se encontraban en el complejo de la cadera, en el complejo del hombro, así como una falta de estabilidad del core.

Published
2021

75. Hypertrophic cardiomyopathy surgery: Perioperative anesthetic management with two different and combined techniques

Author

Verónica López, Javier García Fernández, José J Arcas Bellas, Alberto Forteza, Cristina Sanchez, and Ana Belén Gil González

Subjects
medicine.medical_specialty, business.industry, transesophageal echocardiography, Cardiomyopathy, Hypertrophic cardiomyopathy, Case Report, Perioperative, medicine.disease, hemodynamics, Septal myectomy, Cardiac surgery, Surgery, Sudden cardiac death, Heart disorder, cardiomyopathy hypertrophic, cardiac surgery, Anesthesiology and Pain Medicine, Anesthesiology, Medicine, Ventricular outflow tract, RD78.3-87.3, business, Cardiomyopathy hypertrophic
Abstract

Hypertrophic cardiomyopathy (HOCM) is the most common genetic heart disorder and the most common cause of sudden cardiac death among young population and a major cause of disability for patients of any age. An extended transaortic septal myectomy is the definitive treatment. It is very important to have a good knowledge of the characteristic pathophysiology of the disease in order to optimize intraoperative treatment of these patients. We present a case of a 68-year old woman who underwent hypertrophic elective cardiomyopathy surgery. Anesthetic management is crucial to guarantee maximum safety, since HOCM has the capacity to produce hemodynamic events of such severity that put patient's life at risk. The use and combination of intraoperative transesophageal echocardiography (TEE) and direct measurement of the left ventricular outflow tract gradient provides vital information to ensure successful surgical outcome in patients with HOCM.

Published
2021

76. National consensus on the cardiological treatment and follow-up of Kawasaki disease

Author

de la Torre, Leticia Albert, Martín, Carlos Alcalde, Álvarez-Fuente, María, Rodríguez, Carolina Blanco, García, Gemma Giralt, Gutiérrez-Larraya, Federico, Navarro, Libertad Latorre, Sánchez Andrés, Antonio, Vázquez, Belén Toral, McMullan, Paula de Vera, Pérez, Georges Akel, Alados Arboledas, Francisco Javier, Echauri, Josune Alegría, García, Patricia Aparicio, Arévalo, Paola, Rofes, August Armengol, Sánchez, María Arroyas, Balbacid Domingo, Enrique José, Rodrigo, Antonio Baño, Barcudi Abbona, María Silvina, Fernández, Isabel Barranco, Tascón, Ana Barrios, Bernáldez Torralva, Clara María, Jover, Enrique Blanca, Trigo, Sonia Blázquez, Bravo Sayago, María Jose, Caldeiro Díaz, María Jesús, Cantero Tejedor, María Teresa, Carrasco Moreno, José Ignacio, Blesa, Carmen Carreras, Carretero Bellón, Juan Manuel, Cassanello, María Pia, Malfaz, Fernando Centeno, Cis Spoturno, Adela Cristina, Hernández, Rosa Collell, Costa Orvay, Juan Antonio, Marcos, David Crespo, Cuéllar Manotas, Héctor Augusto, Peiro, Victorio Cuenca, Patricia de Caro, Adalgisa, de la Parte Cancho, María, Degano Iglesias, Lucas Alberto, Bronte, Lucía Deiros, Menéndez, Beatriz del Pozo, Megías, Laura del Rey, Tomás, Juan José Díez, Colina, Paola Dolader, García, Olga Domínguez, Domínguez Garrido, María Nieves, Manzano, Paula Domínguez, Bedoya, Jesús Duque, Espinosa, Javier Echeverría, Echeverría Nava, Fidel Ernesto, Escobar Pinela, Hemir David, Asenjo, María Esquivias, Fariña Ruiz, Ana Patricia, Aracama, Javier Fernández, Sarabia, Javier Fernández, Fernández Soria, María Teresa, Suárez, Natalia Fernández, Belda, Aina Ferré, Villar, Sergio Flores, García, Julio Fontenla, Moure, Ángeles Fuertes, García de Vinuesa, Antonia Pastora Gallego, Arzoz, Marta Gambra, Angleu, Francisco García, Cerro, Estefanía García, Rodríguez-Monte, María Elvira Garrido-Lestache, Villanueva, Nuria Gil, Crespo, Maribel Giner, García, Gema Giralt, González Carrasco, María Ersilia, González Marín, María Aránzazu, Menchén, Cristina González, Ipiña, Fernando Gran, Rodríguez, Inmaculada Guillén, Guixeres Esteve, María Teresa, Gómez, Manuel Haro, Blanco, Aida Hernández, Sánchez, Yolanda Herranz, del Rey, Carmen Herrera, Fernández, Aleida Ibañez, Martín, Gema Iñigo, Fos, Ignacio Izquierdo, Izquierdo Riezu, María Ángeles, Jiménez Casso, María Soledad, Montañés, Lorenzo Jiménez, Labrandero de Lera, Carlos, Abel, Bernardo López, Balseiro, María Lozano, González, José Luaces, Julián, Nazaret Macías, Mairal Cazcarra, Jesús Antonio, Toral, María José Maldonado, Linero, Alejandra Manchola, García, Begoña Manso, Llagaria, MaríMaravall, Alonso, Sonia Marcos, Blanch, Cristina Marimón, Martín de Lara, Ismael, Villar, María Martínez del, Martínez Lorente, María Isabel, Olorón, Patricia Martínez, Martínez Soto, María Isabel, Checa, Laura Marzo, Matamala Morillo, Miguel Ángel, López, Constancio Medrano, Abad, Paula Méndez, Ortiz, Francisco Meza, Gutiérrez, Ana Moriano, Tirado, Antonio Moruno, Montes, Ángeles Ortega, Matamala, Alfonso Ortigado, Garrido, Almudena Ortiz, Erroz, Ignacio Oulego, Argueta, Jorge Roberto Palacios, Agüera, Laura Parra, Molina, Esteban Peiró, Salas, Julio Ernesto Peralta, Perera Carrillo, César Jorge, Campos, Dolores Pérez, Herrera, Verónica Pérez, Moneo Agapito, María Ángeles Pérez, Muñuzuri, Alejandro Pérez, Pérez Pardo, Ana María, Roldán, José María Pérez, Pérez-Lescure Picarzo, Francisco Javier, Pérez-Piaya Moreno, María Rosa, Perin, Francesca, Fuentes, Isabel Pinto, Izquierdo, Beatriz Plata, Morales, María Portoles, Puigdevall Dalmau, María Ángeles, Ovalle, Erika Pulido, Raga Poveda, María Teresa, Rodríguez, Sara Rellán, Rey García, Susana María, Arcelus, Erika Rezola, Méndez, Bibiana Riaño, Armada, Andrés Rico, Jiménez, Natalia Rivero, González, Moisés Rodríguez, Rodríguez Mesa, María Dolores, Serrano, Raúl Rodríguez, Sombrero, María Henar Rojo, Barba, Violeta Román, Ibarra, Carlos Romero, Vivas, Félix Romero, Núñez, Fernando Rueda, Soriano, Joaquín Rueda, Rotés, Anna Sabaté, Salas Salguero, Francisco Javier, Capuñay, Julio Federico Saldaña, Peracaula, Carlos Salido, Andrés, Antonio Sánchez, Calderón, Alberto Sánchez, Vaquerizo, Cristina Sánchez, Pascual, Elena Sanz, Serrano Rob, María Isabel, Sánchez-Manjavacas, Ana Siles, Baladrón, Adolfo Sobrino, García, Ruth Solana, Belmonte, Dolors Soriano, García, Moisés Sorlí, Cabrera, Pedro Suárez, Moreno, Amalia Tamariz-Martel, Moreno, Rocío Tamariz-Martel, Tejero Hernández, María Ángeles, Rico, María Torres, Prat, Susana Uriel, Carrasco, Ana Isabel Usano, Padrino, Estíbaliz Valdeolmillos, Valero Adán, María Teresa, Albert, Sandra Villagrá, Nogales, Javier Villalba, Walter, Carin Cristina, Martín, Marta Yagüe, Zambrano Casajona, María Dolores, Barrios Tascón, Ana, Centeno Malfaz, Fernando, Rojo Sombrero, Henar, Fernández-Cooke, Elisa, Sánchez-Manubens, Judith, and Pérez-Lescure Picarzo, Javier

Published
2018
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79. Unveiling the genomic landscape and adaptive mechanisms of the haloarchaeal genus Halogeometricum: spotlight on thiamine biosynthesis

Author

Dáša Straková, Cristina Sánchez-Porro, Rafael R. de la Haba, and Antonio Ventosa

Subjects
haloarchaea, Halogeometricum, comparative genomic analysis, taxogenomics, thiamine biosynthesis, heavy metals, Science, General. Including nature conservation, geographical distribution, QH1-199.5
Abstract

Recent advances in molecular and metagenomic analyses have enhanced the ability to precisely determine the microbiota of hypersaline environments of marine origin, such as solar salterns, saline lakes, and hypersaline soils, uncovering numerous yet-to-be-isolated prokaryotic groups. Our research focused on the hypersaline ecosystems within the Odiel Saltmarshes, a natural tidal wetland situated at the confluence of the Odiel and Tinto rivers in Huelva province, Southwestern Spain. Employing culture-dependent techniques, we aimed to isolate and characterize novel halophilic prokaryotes from this area. Two haloarchaeal strains, designated S1BR25-6T and S3BR25-2T were classified within the genus Halogeometricum based on Overall Genome Related Indexes (OGRIs) such as Orthologous Average Nucleotide Identity, digital DNA-DNA hybridization, and Average Amino Acid Identity as standard criteria for species delineation. Moreover, this study embarks on an exhaustive genome-based comparative analysis of the haloarchaeal genus Halogeometricum, delineating the metabolic capacities, osmoregulatory adaptations, and resistance to certain heavy metals of its species. The dual osmoregulatory mechanism observed by in-silico analysis of the Halogeometricum species combines “salt-in” and “salt-out” strategies which highlights the adaptive flexibility of these haloarchaea. In addition, capability for de novo thiamine biosynthesis of strain S1BR25-6T along with other Halogeometricum species underscores their metabolic complexity and resilience, offering insights into their role in ecosystem dynamics and potential biotechnological applications. Wet lab experimental analysis of strains S1BR25-6T and S3BR25-2T confirmed their resistance to heavy metals, particularly to arsenic, zinc, and cadmium, emphasizing their potential for bioremediation applications. Furthermore, conducting fragment recruitment analysis across different metagenomic datasets revealed a predominant recruitment of species from the genus Halogeometricum in hypersaline soils of Odiel Saltmarshes (especially the two novel strains), and in the brines of marine saltern ponds with high salt concentrations. These results contribute to a reinforced understanding of the extremely halophilic characteristics inherent to the genus Halogeometricum. Finally, taxogenomic analysis has substantiated that strains S1BR25-6T (= CCM 9250T = CECT 30624T), and S3BR25-2T (= CCM 9253T = CECT 30622T) denote two previously unidentified species within the genus Halogeometricum, for which we propose the names Halogeometricum salsisoli sp. nov., and Halogeometricum luteum sp. nov., respectively.

Published
2024
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80. Uso de las TIC por alumnado de aula hospitalaria: Un estudio de caso

Author

Sara Martínez-Carrera, Cristina Sánchez-Martínez, and Paula Raña-Veloso

Subjects
enseñanza, tecnología, aula hospitalaria, escuela, hogar, Theory and practice of education, LB5-3640
Abstract

El alumnado de las aulas hospitalarias presenta características especiales, al tratarse de niños/as enfermos/as, de forma temporal o crónica. Por este motivo es fundamental atender a su estado físico y psicológico. Las TIC pueden resultar un instrumento muy útil para trabajar con ellos/as, tanto a nivel educativo como emocional. La presente investigación establece como objetivo general descubrir la percepción del profesorado, alumnado y sus familias acerca del uso de las TIC en el aula hospitalaria, así como hacer una comparativa con el aula ordinaria y el hogar. Para ello se aplicó una metodología cualitativa, concretamente un enfoque etnográfico-narrativo, con un estudio de caso. Participaron en total 11 alumnos y alumnas de aula hospitalaria, 4 padres y madres de jóvenes hospitalizados y dos profesoras. Los resultados obtenidos tras el análisis de los datos evidencian la satisfacción de los tres colectivos sobre el uso de las TIC, especialmente en el aula hospitalaria. Destacan como ventajas la promoción del aprendizaje activo y metodologías innovadoras, así como el aumento de la motivación del alumnado; aunque en alguna ocasión se puede generar distracción. Sobresale el uso diario del ordenador, la Pizarra Digital Interactiva y el Smartphone, para realizar tareas académicas y recreativas.

Published
2024
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81. MVA-based vaccine candidates expressing SARS-CoV-2 prefusion-stabilized spike proteins of the Wuhan, Beta or Omicron BA.1 variants protect transgenic K18-hACE2 mice against Omicron infection and elicit robust and broad specific humoral and cellular immune responses

Author

Patricia Pérez, David Astorgano, Guillermo Albericio, Sara Flores, Cristina Sánchez-Corzo, María A. Noriega, Pedro J. Sánchez-Cordón, Nuria Labiod, Rafael Delgado, José M. Casasnovas, Mariano Esteban, and Juan García-Arriaza

Subjects
COVID-19, SARS-CoV-2, MVA-based vaccine, variants of concern, S protein, immunogenicity, Immunologic diseases. Allergy, RC581-607
Abstract

Despite the decrease in mortality and morbidity due to SARS-CoV-2 infection, the incidence of infections due to Omicron subvariants of SARS-CoV-2 remains high. The mutations acquired by these subvariants, mainly concentrated in the receptor-binding domain (RBD), have caused a shift in infectivity and transmissibility, leading to a loss of effectiveness of the first authorized COVID-19 vaccines, among other reasons, by neutralizing antibody evasion. Hence, the generation of new vaccine candidates adapted to Omicron subvariants is of special interest in an effort to overcome this immune evasion. Here, an optimized COVID-19 vaccine candidate, termed MVA-S(3P_BA.1), was developed using a modified vaccinia virus Ankara (MVA) vector expressing a full-length prefusion-stabilized SARS-CoV-2 spike (S) protein from the Omicron BA.1 variant. The immunogenicity and efficacy induced by MVA-S(3P_BA.1) were evaluated in mice in a head-to-head comparison with the previously generated vaccine candidates MVA-S(3P) and MVA-S(3Pbeta), which express prefusion-stabilized S proteins from Wuhan strain and Beta variant, respectively, and with a bivalent vaccine candidate composed of a combination of MVA-S(3P) and MVA-S(3P_BA.1). The results showed that all four vaccine candidates elicited, after a single intramuscular dose, protection of transgenic K18-hACE2 mice challenged with SARS-CoV-2 Omicron BA.1, reducing viral loads, histopathological lesions, and levels of proinflammatory cytokines in the lungs. They also elicited anti-S IgG and neutralizing antibodies against various Omicron subvariants, with MVA-S(3P_BA.1) and the bivalent vaccine candidate inducing higher titers. Additionally, an intranasal immunization in C57BL/6 mice with all four vaccine candidates induced systemic and mucosal S-specific CD4+ and CD8+ T-cell and humoral immune responses, and the bivalent vaccine candidate induced broader immune responses, eliciting antibodies against the ancestral Wuhan strain and different Omicron subvariants. These results highlight the use of MVA as a potent and adaptable vaccine vector against new emerging SARS-CoV-2 variants, as well as the promising feature of combining multivalent MVA vaccine candidates.

Published
2024
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82. Cell death in the developing vertebrate limb: A locally regulated mechanism contributing to musculoskeletal tissue morphogenesis and differentiation

Author

Carlos I. Lorda-Diez, Juan A. Montero, Juan M. Hurle, Cristina Sanchez-Fernandez, and Universidad de Cantabria

Subjects
0301 basic medicine, Programmed cell death, autophagy, Morphogenesis, Reviews, Apoptosis, Review, Biology, Cartilaginous skeleton, 03 medical and health sciences, 0302 clinical medicine, lysosomes, Autophagy, Animals, Cell death genes, Progenitor cell, Process (anatomy), programmed cell death, Cell Death, Mechanism (biology), apoptosis, syndactyly, Gene Expression Regulation, Developmental, Embryo, Cell Differentiation, Extremities, 030104 developmental biology, Vertebrates, Syndactyly, Lysosomes, Neuroscience, cell death genes, 030217 neurology & neurosurgery, Developmental Biology
Abstract

Our aim is to critically review current knowledge of the function and regulation of cell death in the developing limb. We provide a detailed, but short, overview of the areas of cell death observed in the developing limb, establishing their function in morphogenesis and structural development of limb tissues. We will examine the functions of this process in the formation and growth of the limb primordia, formation of cartilaginous skeleton, formation of synovial joints, and establishment of muscle bellies, tendons, and entheses. We will analyze the plasticity of the cell death program by focusing on the developmental potential of progenitors prior to death. Considering the prolonged plasticity of progenitors to escape from the death process, we will discuss a new biological perspective that explains cell death: this process, rather than secondary to a specific genetic program, is a consequence of the tissue building strategy employed by the embryo based on the formation of scaffolds that disintegrate once their associated neighboring structures differentiate., Key Findings We examine the functions of cell death in the formation and growth of the limb primordia.We analyze the plasticity of the cell death program by focusing on the developmental potential of progenitors prior to death.Considering the prolonged plasticity of progenitors to escape from the death process and the absence of defined genetic program in their regulation we propose that cell death is a consequence of the tissue building strategy employed by the embryo regulated by epigenetic factors .

Published
2020

83. Using the Picture Word Inductive Model, Art and ACTFL 5 C’s to learn a second or foreign language

Author

Ana Cristina Sanchez and Maria Elena Arias-Zelidon

Subjects
Medical Terminology, Foreign language, ComputingMilieux_COMPUTERSANDEDUCATION, Psychology, Word (computer architecture), Linguistics, Medical Assisting and Transcription
Abstract

This paper will examine how art can be used as a visual aid and a primary input to teach and learn the Spanish language and culture. Art will be limited to the use of photographs and paintings that will be combined with the Picture Word Inductive Model [PWIM] and the 5C goal areas on the teaching of a foreign language as recommended by the American Council on the Teaching of Foreign Languages [ACTFL]. The five C goals stand for Communications, Culture, Connections, Comparisons, and Communities. The Picture Word Inductive Model [PWIM] was developed by the Language Arts Specialist, Emily Calhoun in 1998 to help children expand their vocabulary repertoire and develop reading and writing skills using pictures. Art is a meaningful input that promotes vocabulary acquisition, listening, speaking, and literacy skills. It can be incorporated into any curriculum regardless of the language methodology to build background knowledge, scaffolding as a bridge from existing knowledge and new information. Art also promotes motivation on the students ‘part, which is a key aspect to successful learning. The researchers will provide a unit plan that can be incorporated in a fourth or fifth-semester Spanish course.

Published
2020

84. Contributors

Author

E.A. Adebayo, Sevinc Adiloglu, Rishabh Agrahari, Sakshi Agrawal, S.O. Ajao, Luis H.C. Andrade, Prathmesh Anerao, Gilberto J. Arruda, Sara Julliane Ribeiro Assunção, Sneha Bandyopadhyay, Cácio Luiz Boechat, Marcela Rebouças Bomfim, Marcelo L. Bueno, Adrián Cabo, Anderson R.L. Caires, Claudio Cameselle, Emanuelle Burgos Cardoso, Kaíque Mesquita Cardoso, María Celeste Schierano, Srishti Chakraborty, Archi Chaurasia, Gabriela Cristina Sanchez, Daniel Gomes Coelho, Valéria F.B. da Silva, Moumita Das, Saurav Das, Sohel Das, Suchismita Das, Bidyalaxmi Devi, Chinmayee M. Devi, Daljeet Singh Dhanjal, Gisela Alfonsina Di Luca, Nawal Kishore Dubey, Sandra Ester Caffaratti, Sarah Farrukh, Deepak Ghimire, Dipita Ghosh, Susana Gouveia, Renato Grillo, Bharat Arjun Gudade, Hernán Ricardo Hadad, Fengxiang X. Han, Anindita Hazarika, Deniz Izlen Cifci, Sadaf Jan, Javaria Kanwal, Kavitha Ramamoorthy, Roshan Kaware, Akshay Kumar Khedikar, Komal Prasad, Fanlong Kong, Bhupendra Koul, Akshay Kumar, Hemant Kumar, Manish Kumar, Santosh Kumar, Sunil Kumar, Vijay Kumar, Vineet Kumar, Lavanya Muthusamy, Sandro M. Lima, Arjun Mahato, María Alejandra Maine, Subodh Kumar Maiti, Manikandan Rajendran, Mathiyazhagan Narayanan, Kisholay Mazumdar, Süreyya Meric, Rafael de Souza Miranda, Arti Mishra, Sonali Mohanty, Swati Mohapatra, Uma Sankar Mondal, María de las Mercedes Mufarrege, Sara Mussaddiq, Kiran Mustafa, Emanuel Nocetti, A.F. Ogundola, Özge Bahar Özkoç, Parul Parihar, Siraj Yousuf Parray, Subhankar Paul, María del Carmen Pedro, Montcharles S. Pontes, Jitendra Prasad, Praveen C. Ramamurthy, Vivek Rana, Krishna R. Reddy, Sabariswaran Kandasamy, Nadia Saddiq, Shilpa Sakia, Etenaldo F. Santiago, Jaqueline S. Santos, Jorge Antonio Gonzaga Santos, Ankush D. Sawarkar, Sushil Kumar Shahi, Iqra Shakeel, Chitrakshi Shandilya, Shailja Sharma, Bijendra Kumar Singh, Lal Singh, Simranjeet Singh, Joginder Singh, Ashish K. Singh, Balaji Bhaskar Maruthi Sridhar, Yi Su, T.S. Swapna, Simran Takkar, Nagendra Thakur, Shikha Tiwari, Ajit Varma, Kanchan Vishwakarma, Sen Wang, Meera Yadav, Hardeo Singh Yadav, Günay Yildiz Töre, and Muhammad Younas

Published
2022

85. Molecular Weight Analysis of Blue Shark (Prionace glauca) Collagen Hydrolysates by GPC-LS; Effect of High Molecular Weight Hydrolysates on Fibroblast Cultures: mRNA Collagen Type I Expression and Synthesis

Author

Ricardo Perez-Martin, Carmen Gonzalez Sotelo, Ana Cristina Sanchez, Noelia Sanz Pereira, Maria Blanco Comesaña, and Begoña Correa

Subjects
QH301-705.5, Fish by-products, Organic Chemistry, GPC-LS, General Medicine, Molecular weight, Catalysis, Computer Science Applications, mRNA collagen expression, Inorganic Chemistry, Chemistry, Fish protein hydrolysates, Ppro-collagen, Fibroblast, Collagen, Biology (General), Physical and Theoretical Chemistry, fish by-products, collagen, fish protein hydrolysates, molecular weight, fibroblast, pro-collagen, QD1-999, Molecular Biology, Spectroscopy
Abstract

14 pages, 8 figures, 4 tables.-- This is an open access article distributed under the Creative Commons Attribution License, High molecular weight (Mw) collagen hydrolysates have been demonstrated to produce a higher synthesis of collagen type I mRNA. Mw determination is a key factor maximizing the effect of collagen hydrolysates on collagen type I synthesis by fibroblasts. This work aimed to achieve a high average Mw in Blue Shark Collagen Hydrolysate, studying different hydrolysis parameters by GPC-LS analysis and testing its effect on mRNA Type I collagen expression. Analysis revealed differences in blue shark collagen hydrolysates Mw depending on hydrolysis conditions. Papain leads to obtaining a significantly higher Mw hydrolysate than Alcalase at different times of hydrolysis and at different enzyme/substrate ratios. Besides, the time of the hydrolysis factor is more determinant than the enzyme/substrate ratio factor for obtaining a higher or lower hydrolysate Mw when using Papain as the enzyme. Contrary, Alcalase hydrolysates resulted in similar Mw with no significant differences between different conditions of hydrolysis assayed. Blue shark collagen hydrolysate showing the highest Mw showed neither cytotoxic nor proliferation effect on fibroblast cell culture. Besides, it exhibited an increasing effect on both mRNA expression and pro-collagen I production, This research was funded by the project BlueHuman, EU_EAPA_151/2016 and Xunta de Galicia (Grupos de Potencial Crecimiento, IN607B2021/11)

Published
2022

89. Effect of Process Parameters on Bioelectricity Production, Energy and Environmental Performance

Author

Luiz Alexandre Kulay, Laíse Anton, Claudia Cristina Sanchez Moore, and Fernando Henrique Cardoso

Subjects
lcsh:T, Renewable Energy, Sustainability and the Environment, business.industry, Energy performance, Energy Engineering and Power Technology, Environmental Science (miscellaneous), lcsh:Technology, lcsh:HD72-88, ELETROFISIOLOGIA, lcsh:Economic growth, development, planning, Sugarcane biomass, Cogeneration, Life cycle assessment, Bioelectricity, Scientific method, Production (economics), Environmental science, Process engineering, business, Life-cycle assessment, Energy (signal processing), Water Science and Technology
Abstract

This study evaluates the energy and environmental performance of a cogeneration system operating simultaneously with bagasse and straw in a rankine cycle. Different process conditions, defined in terms of boiler operating pressure, moisture content and straw addition rate, were analyzed. The combination of these parameters led to the elaboration of one hundred and twenty-five analysis scenarios. The energy profile was based on the energy performance indicator, which is the ratio between the exported electricity and the intrinsic energy of biomass consumed for its generation, and the environmental assessment was performed in terms of climate change. Scenario modeling was developed according to the conceptual framework proposed by the life cycle assessment technique with a ‘from cradle-to-gate’ coverage. Results indicate that the best energy and environmental performances (energy performance indicator = 0.193 and 688 kg CO2eq/MWh) were obtained with the highest pressure (100 bar) and addition rate (50%), and the lowest moisture content (10%). Moreover, straw moisture has more influence on the system environmental performance than its addition rate.

Published
2019

90. Competencia emocional en docentes de Infantil y Primaria y estudiantes universitarios de los Grados de Educación Infantil y Primaria

Author

HELENA-FUENSANTA MARTINEZ-SAURA, CRISTINA SANCHEZ LÓPEZ, and Juan-Carlos Pérez-González

Subjects
Educación Infantil, Educación Primaria, Empatía, Inteligencia emocional, Education
Abstract

El estudio, descriptivo-correlacional, evalúa la competencia emocional de docentes de Infantil y Primaria y de estudiantes universitarios de los Grados de Educación Infantil y Primaria. Se contó con una submuestra de 92 docentes y otra de 290 estudiantes. La competencia emocional se defi nió operacionalmente a partir de dos indicadores: meta- estados de ánimo y empatía cognitiva-afectiva. Los resultados revelan que el nivel de desarrollo en la mayoría de los componentes de la competencia emocional estudiados son superiores en quienes tienen mayor experiencia (docentes vs. estudiantes) y poseen algún grado de formación emocional, lo que indirectamente avala la modifi cabilidad de la competencia emocional.

Published
2021

91. Observation of excited Ωc0 baryons in Ωb−→Ξc+K−π− decays

Author

Matteo Rama, Harris Conan Bernstein, C. Bozzi, Sara Elizabeth Mitchell, Monica Pepe Altarelli, Mika Vesterinen, Veronika Chobanova, Jan Langer, Aleksandr Petrov, Xiaoxue Han, Stephane T'Jampens, Giacomo Graziani, Ross John Hunter, Pablo Vazquez Regueiro, Vlad-Mihai Placinta, Erica Polycarpo, Jennifer Brigitta Zonneveld, Dmitry Golubkov, Kevin Heijhoff, Lorenzo Capriotti, Samuel Belin, Stefania Ricciardi, Constantin Weisser, Dmytro Melnychuk, Agnieszka Dziurda, Stephen Farry, Marta Calvi, Miroslav Saur, Antonios Papanestis, Paul Nathaniel Swallow, Yuezhe Yao, Halime Sazak, Maarten van Veghel, G. Alkhazov, Michael McCann, Alexandre Boyer, Charlotte Barbara Van Hulse, Elisabetta Spadaro Norella, Jose Lopes, Giulia Manca, Mengzhen Wang, Giovanni Punzi, Artem Maevskiy, Wojciech Wislicki, Mikhail Hushchyn, Ekaterina Trifonova, Thierry Gys, Alexandre Brea Rodriguez, Oleg Yushchenko, Thomas Peter Jones, A. Jawahery, Diego Torres Machado, Renaud Le Gac, Andrea Lampis, Xuhao Yuan, Jiayin Sun, Davide Zuliani, Jike Wang, Patrick Mackowiak, Thomas Boettcher, Ryan Newcombe, Ilia Belov, Evgenii Shmanin, Matthew Birch, Heinrich Schindler, Silvia Borghi, Pavel Krokovny, Qundong Han, Sophie Katharina Kretzschmar, Guoming Liu, Boleslaw Pietrzyk, Mario Edgardo Olivares, Rui Wang, Svende Braun, Bo Fang, Eddy Jans, Sergey Filippov, Maciej Wojciech Dudek, Michele Veronesi, Zakariya Aliouche, Andreas Schopper, Camille Normand, Wojciech Kucewicz, Yiduo Shang, Maksim Karpov, Igor Kostiuk, Anna Lupato, Razvan Daniel Moise, Antonio Fernandez Prieto, Jiesheng Yu, Miriam Gandelman, Ivan Belyaev, Mariia Poliakova, Sergii Kandybei, Roger Barlow, Martin Stefan Bieker, Daniel Charles Craik, Jan-Marc Basels, Konstantin Gizdov, Wiktor Byczynski, Federico Redi, George Lafferty, Quan Zou, George Coombs, Alastair Roger Tanner, Hui Li, Federico Alessio, Minh Tâm Tran, Anatoliy Dovbnya, Fabio Ferrari, George Holger Lovell, Silvia Ferreres Sole, Maria Vieites Diaz, Andrea Contu, Marco Poli Lener, A. Artamonov, Hongrong Qi, Michal Kazimierz Mazurek, Antonio Falabella, Carmen Giugliano, Manuel Schiller, Lauren Douglas, Marcos Romero Lamas, Stephane Monteil, Francesco Dettori, Tatiana Gaintseva, Pierre Billoir, Titus Mombächer, Thomas Grammatico, Yangheng Zheng, Carmelo D'Ambrosio, Jean François Marchand, Oleg Stenyakin, Roman Litvinov, Aleksandr Terentev, Jonas Rademacker, Marco Santimaria, Mark Hatch, Roberto Calabrese, Louis Lenard Gerken, Mirco Andreotti, Yu Zhang, Xiaokang Zhou, Stephan Escher, Adriano Lai, Tatiana Ovsiannikova, Arthur Marius Hennequin, Jan Maratas, Marek Jezabek, Michael Brodski, Heather Mckenzie Wark, Patrick Koppenburg, Lei Zhang, Sandro Cadeddu, Yipeng Sun, Gerd Joachim Kunde, C. M. Costa Sobral, Jozef Tomasz Borsuk, Johannes Heuel, Yu Lu, Sebastian Schulte, Huanhuan Liu, Nikolay Bondar, Niko Neufeld, Marianna Fontana, Tomasz Skwarnicki, Roberto Ribatti, Stephen M. Stahl, Wojciech Krupa, Oleksander Kot, Alison Tully, Dorothea Vom Bruch, Viacheslav Duk, Zishuo Yang, Alessandro Petrolini, Sergey Legotin, Juan Mauricio, Renato Quagliani, Florin Maciuc, Brij Kishor Jashal, Lorenzo Pica, Marco Petruzzo, Marian Stahl, Yasmine Amhis, Gabriela Johanna Pomery, Matteo Giovannetti, Alexey Boldyrev, John Matthew Durham, Julián García Pardiñas, Naomi Veronika Raab, Jianqiao Wang, Igor Slazyk, Alexandru Grecu, Thomas Ackernley, Niladribihari Sahoo, Eric Cogneras, Alexander Malinin, Biagio Saitta, Stanislav Luchuk, Tengiz Kvaratskheliya, Clara Remon Alepuz, Angel Fernando Campoverde Quezada, Mihai Straticiuc, Eliane Epple, Wenqian Huang, Cibran Santamarina Rios, Efren Rodriguez Rodriguez, Serhii Koliiev, A. Palano, Tomasz Szumlak, Simon Nieswand, Eric van Herwijnen, Dongliang Zhang, Annarita Buonaura, Valery Zhukov, Chen Chen, Anton Philippov, Nicola Serra, Stephanie Hansmann-Menzemer, Zirui Wang, Sofia Kotriakhova, Jihyun Bhom, Kazuyoshi Carvalho Akiba, Yutong Li, Sebastian Bachmann, Andrew George Morris, Sneha Malde, Konstantinos Petridis, Lucas Meyer Garcia, Abbie Jane Chadwick, Flavio Pisani, Antje Mödden, Yang Gao, U. Uwer, Kenneth Wyllie, Davide Fazzini, Cheryl Pappenheimer, Lais Soares Lavra, Marcin Chrzaszcz, Carla Göbel, Michael Alexander, Liliana Congedo, Antonio Romero Vidal, Thomas Henry Hancock, Vladimir Macko, Yury Guz, Regis Lefèvre, Valerie Gibson, Patrizia De Simone, Shuaiyi Liu, Marie-Noelle Minard, Clara Gaspar, Davide Lancierini, Lavinia-Helena Giubega, Rafal Dominik Krawczyk, Daniel Patrick O'Hanlon, Ricardo Vazquez Gomez, David Anthony Friday, Lorena Dieste Maronas, Dana Bobulska, Alessandro Bertolin, Lakshan Ram Madhan Mohan, Yue Pan, Peter Griffith, Elie Aslanides, Alexandra Paige Rollings, John Leslie Cobbledick, T. Lesiak, Alexander Inglessi, Thomas Ruf, Da Yu Tou, Rolf Lindner, Stefano Perazzini, Martino Borsato, Claudia Bertella, Marilisa De Serio, V. Obraztsov, Christopher Betancourt, Andrea Merli, Ekaterina Govorkova, Gerco Onderwater, Stephan Eisenhardt, Dario de Simone, Juan Baptista Leite, Michael Schmelling, Stefano Cali, Suzanne Klaver, William Barter, Martina Pili, Angelo Carbone, Bartlomiej Rachwal, Jaap Velthuis, Luke George Scantlebury Smead, Guido Haefeli, Ivan Solovyev, Vasily Kudryavtsev, Hang Yin, Jacopo Cerasoli, Dmitrii Maisuzenko, Hans Dijkstra, Maxim Borisyak, Lucian Cojocariu, Sevda Esen, Ulrik Egede, Piera Muzzetto, Diego Martinez Santos, Alex Seuthe, Wolfgang Funk, Rafael Silva Coutinho, Resmi Pk, Ivan Polyakov, David Hutchcroft, Matthew George Chapman, Marko Milovanovic, Emilie Maurice, Marko Petrič, A. Gomes, Federico Betti, Maria Aranzazu Oyanguren, Paul Andre Günther, Jing Wang, Shakhzod Dadabaev, Tabitha Halewood-leagas, Alexander Vagner, Anna Danilina, Artur Ukleja, Mark Wilkinson, Roland Waldi, Timofei Maltsev, O. Schneider, Thomas Kirn, Rosen Matev, Mark E. Smith, Katharina Müller, Fernanda Goncalves Abrantes, Tara Shears, B.R. Gruberg Cazon, Vitaly Vorobyev, Zan Ren, Alex Daniel Fernez, Matthew Charles, Feng Jiang, Matthieu Marinangeli, Christine Angela Aidala, Dirk Wiedner, Maria Flavia Cicala, R. I. Rabadan Trejo, Eva Vilella Figueras, Ievgenii Petrenko, Christopher Parkes, Stefan Schael, Olivier Leroy, Mark Richard James Williams, Flavio Fontanelli, Mikhail Zavertyaev, Iaroslava Bezshyiko, Jose Maria Fernandez-tenllado Arribas, Aleksei Chernov, Ivan Shchemerov, Florian Reiss, Jonas Nathanael Eschle, Natalia Polukhina, Karol Hennessy, Wenhua Hu, Julian Alexander Boelhauve, Youen Kang, Marcel Merk, Daniel Decamp, Jairo Alexis Rodriguez Lopez, Ouail Kitouni, S. Blusk, Alex Pearce, Edoardo Franzoso, Anton Poluektov, Lorenzo Sestini, Polina Kravchenko, Lucio Anderlini, Fidan Suljik, Sara Celani, Sune Jakobsen, Simone Meloni, Valeriia Lukashenko, Oscar De Aguiar Francisco, Harald Viemann, Alexander Leflat, Johannes Albrecht, Malcolm John, Nicola Skidmore, Leonid Kravchuk, Vasyl Dobishuk, Saverio Mariani, Vukan Jevtic, Alexey Zhelezov, Fedor Baryshnikov, Aravindhan Venkateswaran, Zhihao Xu, Cesar Luiz da Silva, Jia-Jia Qin, Themistocles Bowcock, Blaise Delaney, Amanda May Donohoe, William Parker, Donal Hill, Anna Ossowska, Nathan Jurik, Zhenzi Wang, Stanislav Poslavskii, Maxime Schubiger, Veronica Soelund Kirsebom, Pere Gironella Gironell, Kamil Leszek Fischer, Giovanni Passaleva, Thi Thuy Hang Pham, Daniele Marangotto, Marco Adinolfi, Adlène Hicheur, Benedict Donald C Westhenry, Emmy Gabriel, Alessandro Minotti, Benedetto Gianluca Siddi, Jascha Peter Grabowski, Yiheng Luo, Deepanwita Dutta, Mauro Morandin, Vitalii Lisovskyi, Lei Li, Laura Promberger, Vladislav Balagura, Zhiyu Xiang, Chung Nguyen-Mau, Frederic Teubert, David Gerick, Vinicius Franco Lima, Ina Carli, Preema Rennee Pais, Luis Miguel Garcia Martin, Gregory Ciezarek, Xiao-Rui Lyu, Matthias Karacson, Xiaotao Huang, Alessio Sarti, Hangyi Wu, Jakub Ryzka, F. Muheim, Philippe Ghez, Timothy Evans, Nuria Valls Canudas, Stefano Petrucci, Ignacio Bediaga, Desmond Mzamo Shangase, Cristina Sanchez Gras, Daniel Johnson, Matteo Salomoni, Thomas Harrison, Mariusz Witek, Chenxi Gu, Donatella Lucchesi, Evangelos Leonidas Gkougkousis, Paolo Gandini, Kurt Rinnert, Felipe Luan Souza De Almeida, John Walsh, David Sanchez Gonzalo, P. Spradlin, Patricia Camargo Magalhaes, Paul Soler, Jeremy Dalseno, Beat Jost, Tjeerd Ketel, Milosz Zdybal, L. Sun, Andrey Ustyuzhanin, Alexandru Ene, John Gordon Smeaton, Artem Ryzhikov, Sajan Easo, Bernardo Adeva, Guy Wilkinson, Guanghua Gong, Matthew Kenzie, Niels Tuning, Nis Meinert, Luciano Pappalardo, Kenenbek Arzymatov, Tamaki Holly Mcgrath, Alessia Satta, Dmitrii Pereima, Sai-Juan Chen, Oleksandr Zenaiev, Fedor Ratnikov, Jacco de Vries, Jibo He, Lex Marinus Greeven, Cameron Thomas Dean, Alberto dos Reis, Davide Brundu, Matteo Bartolini, Michal Kreps, Paolo Ciambrone, Youhua Yang, Daniel Berninghoff, Vincenzo Vagnoni, Colm Harold Murphy, Giovanni Carboni, Mauro Piccini, Christopher John Parkinson, Matthew Needham, Giovanni Cavallero, Joseph David Shupperd, Stefania Vecchi, Hanna Malygina, Edward Brendan Shields, Yixiong Zhou, Felipe Andres Garcia Rosales, Thomas Latham, Oleg Maev, Patrick Robbe, Lluis Garrido, Luigi Del Buono, Jinlin Fu, Alessandra Pastore, C. Patrignani, Alexey Dzyuba, V. Tisserand, Luca Tomassetti, Marie Bachmayer, Alessandro Cardini, Ifan Williams, Dawid Gerstel, Xabier Cid Vidal, Luca Minzoni, Dylan Jaide White, Michela Garau, Christoph Langenbruch, Gianluigi Casse, Paula Alvarez Cartelle, Jennifer Clare Smallwood, Jana Crkovská, Aleksandra Snoch, Lev Shekhtman, Pascal Perret, Fionn Caitlin Ros Bishop, Stefano Zucchelli, Quentin Fuehring, Phillip John Marshall, Mikhail Mikhasenko, Andrea Bizzeti, Kristof De Bruyn, Chishuai Wang, Dominik Stefan Mitzel, Marco Clemencic, Eluned Smith, Tommaso Colombo, Angelo Loi, Salvatore Aiola, Philip Ilten, Gloria Corti, Blake Leverington, Wojciech Krzemien, Benjamin Couturier, Gianfranco Morello, Mikkel Bjørn, Mark Slater, Pawel Kopciewicz, Jialu Wang, Raja Nandakumar, Aristeidis Fkiaras, Vladislav Belavin, Andrea Valassi, Tara Nanut, Carlos Vázquez Sierra, Roger Forty, Alexander Battig, Holger Stevens, Baasansuren Batsukh, Timothy Gershon, Imanol Corredoira, Daniel Joachim Unverzagt, Basem Khanji, Srishti Bhasin, Roberta Cardinale, Leandro De Paula, Claudio Gotti, Andrea Villa, Robbert Erik Geertsema, Zehua Xu, Daria Strekalina, Saverio Simone, Dominik Müller, Daniel Lacarrere, Felix Johannes Kress, Celestina Satriano, Eduard Ursov, Evelina Gersabeck, Barbara Passalacqua, Shunan Zhang, Jonathan Plews, Matthew John Bradley, Hongjie Mu, Richard Jacobsson, Malte Hecker, Mauricio Féo, Shantam Taneja, Thomas Blake, Yuyue Gan, Anatoly Butkevich, Marek Idzik, Liupan An, Mikhail Korolev, Gabriele Simi, Lukas Witola, Lino Ferreira Lopes, Albert Bursche, Anthony Gavin Downes, Joan Ruiz Vidal, Benjamin Audurier, Miriam Lucio Martinez, Jiangqiao Hu, Xavier Vilasis-Cardona, Thomas Hadavizadeh, Minaugas Sarpis, Sara Sellam, Denis Derkach, F. Ferreira Rodrigues, Julien Cogan, Giulia Tuci, Thi Dung Nguyen, Jussara De Miranda, Phoebe Meredith Hamilton, Eric Thomas, Xixin Liang, Almagul Kondybayeva, Tai-Hua Lin, Scott Ely, Burkhard Schmidt, Carlos Abellán Beteta, Jan Buytaert, Konstantin Belous, Giulia Frau, Lishuang Ma, Diego Alejandro Milanes, Giuseppe Martellotti, Henryk Karol Giemza, Mitesh Patel, B. Spaan, Sergey Barsuk, Ruiting Ma, Oliver Lantwin, Victor Egorychev, Valery Pugatch, Arnau Brossa Gonzalo, Emanuele Santovetti, Marina Artuso, Xiaofan Hu, Ryan Calladine, Floris Keizer, François Fleuret, Francesco Polci, Anastasiia Kharisova, Michael Sokoloff, Philipp Roloff, Federico Lazzari, Dong Xiao, Alberto Lusiani, Pierluigi Campana, Lesya Shchutska, Zhanwen Zhu, Michael Williams, Victor Coco, R. McNulty, Irina Nasteva, Pablo Baladron Rodriguez, Zhuoming Li, Michele Veltri, Roel Aaij, Vadym Denysenko, Sergei Popov, Eduardo Rodrigues, Abraham Gallas Torreira, Vladimir Romanovskiy, Melissa Maria Cruz Torres, Marie Helene Schune, James Vincent Mead, Daniel Hynds, Federico Stagni, Paula Garcia Moreno, Donal Murray, Christophe Haen, Clara Matteuzzi, Biplab Dey, Martinus van Beuzekom, Pascal Vincent, Marcel Materok, Fergus Wilson, Alina Zharkova, Rizwaan Adeeb Mohammed, Alexsei Chubykin, Maarten Van Dijk, Elena Graverini, Olivier Deschamps, Niklas Stefan Nolte, Flavio Archilli, Matteo Palutan, A. Bay, Mikhail Shapkin, G. Raven, Alexander Bondar, Lingzhu Bian, Darya Savrina, Shiyang Li, Sergio Gomez Fernandez, Naomi Cooke, Andrea Mauri, Wenbin Qian, Menglin Xu, Loris Martinazzoli, Ao Xu, Mara Senghi Soares, Jakob Haimberger, Elisabeth Maria Niel, Sonia Amina Bouchiba, Adam Dendek, Yuehong Xie, Anastasia Smetkina, Mark Whitehead, Lucas Mcconnell, Semen Eidelman, Konrad Klimaszewski, Anatoly Konoplyannikov, Maciej Pawel Szymanski, Jakub Jacek Malczewski, Guillaume Pietrzyk, Danila Saranin, Andrii Usachov, Marco Pappagallo, Paul Seyfert, Abhijit Mathad, Daniel Vieira, Ming Zeng, Tommaso Pajero, Andrew Beiter, Lars Eklund, Leon David Carus, Alexander Bitadze, Beatriz Garcia Plana, Yanxi Zhang, Oscar Boente Garcia, Sebastian Neubert, Martha Hilton, Cynthia Nunez, Conor Fitzpatrick, Antonino Sergi, Mark Tobin, Dmitrii Ilin, Yanting Fan, Alexey Vorobyev, Ziad Ajaltouni, Liliet Calero Diaz, Gianluca Zunica, Eleonora Luppi, Robert Currie, Edward James Millard, Marco Gersabeck, Andrey Golutvin, I. V. Gorelov, Giovanni Bassi, Shuangli Yang, John Back, Christoph Hasse, Christopher James Pawley, Lukas Calefice, Christopher Burr, Maria Elena Stramaglia, Michele Piero Blago, Zhihong Shen, Hao Cai, Dillon Scott Fitzgerald, Andreas Güth, Frederic Machefert, Sheldon Stone, Peter Svihra, Jifeng Hu, Yilong Wang, Peilian Li, Domenico Galli, Maximo Plo Casasus, E. Grauges, Joel Closier, Luis Alberto Granado Cardoso, John Jake Lane, Rudolf Oldeman, Joao A B Coelho, Massimiliano Fiorini, Ryunosuke Hugo O'Neil, Miriam Calvo Gomez, Carla Marin Benito, Evgeny Gushchin, Ilaria Neri, Oliver Lupton, Artur Ishteev, Stefano De Capua, Umberto Marini Bettolo Marconi, Silvia Gambetta, Sergei Kholodenko, Simon Akar, Christopher Jones, Raymond Mountain, Markus Frank, Kimberley Vos, Naylya Sagidova, Maurizio Martinelli, Francesca Dordei, Paolo Durante, Karlis Dreimanis, Sophie Elizabeth Hollitt, Carina Trippl, Lucia Grillo, Aleksandr Solovev, David Websdale, Bartosz Malecki, Roland Bernet, Nikolay Nikitin, Philippe d'Argent, Massimiliano Ferro-Luzzi, Alexander Semennikov, Sebastien Ponce, Kayleigh Anne Thomson, Daniele Manuzzi, Nikolai Voropaev, Paras Naik, Zoltan Mathe, Bruno Souza De Paula, Wouter Hulsbergen, Marco Guarise, Kevin Heinicke, Kara Renee Mattioli, Mateusz Goncerz, Barbara Sciascia, Boris Quintana, Jordan Daniel Roth, Hossein Afsharnia, Julian Lomba Castro, Agnieszka Oblakowska-Mucha, Maik Becker, André Massafferri, Martina Ferrillo, Juan Jose Saborido Silva, Ettore Zaffaroni, Adam Szabelski, Krzysztof Swientek, Ning Qin, Olga Madejczyk, Franco Bedeschi, Simone Capelli, Brian Meadows, Roberta Santacesaria, Mick Mulder, Antonio Pellegrino, F. Blanc, Jingzhou Fan, Peter Clarke, Murilo Rangel, Dmitry Popov, Tatsuya Nakada, Olaf Steinkamp, G. Bencivenni, Viacheslav Matiunin, Marco Cattaneo, Michel De Cian, Michele Atzeni, Li Xu, Hannah Louise Pullen, Surapat Ek-In, Yang Li, Miroslaw Firlej, Lauren Emma Yeomans, Elena Dall'Occo, Paolo Carniti, Meril Reboud, Ana Barbara Rodrigues, Alexander Berezhnoy, Alexander Mclean Marshall, Vladimir Shevchenko, Elisabet Golobardes, Xianglei Zhu, Di Yang, Sergey Didenko, Simone Bifani, Stephen Wotton, Nigel Watson, Marcelo Soares, Jakub Moron, Kodassery Prasanth, Zhenwei Yang, Richard Lane, Gediminas Sarpis, Matthew Scott Rudolph, Manuel Franco Sevilla, Adam Benjamin Morris, Georgios Chatzikonstantinidis, Samuel Maddrell-Mander, A. Alfonso Albero, G. Wormser, Violaine Bellee, Miguel Ramos Pernas, Vladimir Chulikov, Alessandra Gioventù, Philippe Charpentier, Serhii Cholak, Renata Kopecna, Sook Hyun Lee, Christoph Frei, Rainer Schwemmer, Andrew McNab, Pasquale Di Nezza, Hans Peter Dembinski, Gary Robertson, Sergey Gromov, Gaia Lanfranchi, Bhagyashree Pagare, Louis Henry, Hilbrand Steffen Kuindersma, Rosa Anna Fini, Tomasz Fiutowski, Qingnian Xu, P. Collins, Gerwin Meier, Serena Maccolini, Jan Patrick Hammerich, Jörg Marks, C. A. Chavez Barajas, Claire Prouve, Gennady Panshin, Neville Harnew, Giovanni Valenti, Davide Pinci, Patrick Owen, Michael Joseph Morello, Giampiero Mancinelli, Fabrice Desse, Vladimir Gligorov, Kuzma Ivshin, Igancio Alberto Monroy, Marcello Rotondo, Philipp Ibis, Fernando Martinez Vidal, Pavol Stefko, Jordy Sebastiaan Butter, Marcin Kucharczyk, Maximilien Chefdeville, Maciej Witold Majewski, Adam Davis, Alessandro Scarabotto, Aleksei Andreianov, E. Ben-Haim, Alessandro Di Cicco, Jingyi Xu, Harry Cliff, Steffen Georg Weber, Wander Baldini, Victor Renaudin, Iain Longstaff, Adrian Casais Vidal, Sandra Amato, Petr Andreevich Gorbounov, Jolanta Brodzicka, Biljana Mitreska, Juan Martin Otalora Goicochea, Laurent Dufour, and Nicola Neri

Subjects
Baryon, Physics, 010308 nuclear & particles physics, Branching fraction, Excited state, 0103 physical sciences, Pi, Center of mass, Atomic physics, 010306 general physics, Spin (physics), 01 natural sciences, Luminosity
Abstract

The first observation of the Ω b - → Ξ c + K - π - decay is reported using p p collision data at center of mass energies of 7, 8, and 13 TeV collected by the LHCb experiment, corresponding to an integrated luminosity of 9 fb - 1 . Four excited Ω c 0 baryons are observed in the Ξ c + K - mass projection of the Ω b - → Ξ c + K - π - decays with the significance of each exceeding five standard deviations. They coincide with the states previously observed in prompt p p and e + e - production. Relative production rates, masses, and natural widths of the states are measured, and a test of spin hypotheses is performed. Moreover, the branching ratio of Ω b - → Ξ c + K - π - is measured relative to the Ω b - → Ω c 0 π - decay mode and a precise measurement of the Ω b - mass of 6044.3 ± 1.2 ± 1. 1 - 0.22 + 0.19 MeV is obtained.

Published
2021

92. Genetic Contributions to Early and Late Onset Ischemic Stroke

Author

Cristina Sanchez-Mora, Jie Hu, Philippe Amouyel, Annette Peters, Charles C Hong, Mary Cushman, Kathleen A. Ryan, Jiang Li, Liming Li, Thomas Jaworek, Sylvia Wassertheil-Smoller, Tiina Metso, Martin Soderholm, Kathryn M. Rexrode, Nicholas L. Smith, Jane Maguire, Martina Müller-Nurasyid, Agnieszka Slowik, Marguerite R. Irvin, Adam S. Butterworth, Martin O’Donnell, Leema Reddy Peddareddygari, Rainer Malik, Ralph L. Sacco, Brady Gaynor, Christian Geiger, Debashree Ray, Anne-Katrin Giese, John W. Cole, Jon Peter Durda, Vincent Thijs, Jukka Putaala, Michiaki Kubo, O. Colin Stine, Rebecca D. Jackson, Israel Fernandez-Cadenas, Reinhold Schmidt, Aki S. Havulinna, Kuang Lin, Christopher Levi, Steven Bell, Timothy O’Connor, Daniel Woo, Jara Cárcel-Márquez, Braxton D. Mitchell, Christina Jern, Jonathan Rosand, Sharon L.R. Kardia, Pankaj Sharma, Mina A. Jacob, Masaru Koido, Vida Abedi, Yoichiro Kamatani, Kristiina Rannikmäe, Michael Chong, Nuria P. Torres-Aguila, Cathie L. M. Sudlow, Ramin Zand, Elizabeth Holliday, Tatjana Rundek, Jessica D. Faul, Leslie Lange, Gunnar Engstrom, Marc C. Hochberg, Bradford B. Worrall, Hugh S. Markus, Joanna Pera, Jordi Jimenez-Conde, Caitrin W. McDonough, Raji P. Grewal, Owen Ross, Robin G. Walters, David J. Duggan, Guillaume Paré, Turgut Tatlisumak, Laura Heitsch, Jin-Moo Lee, Natalie Fecteau, Robin Lemmens, Jennifer A. Smith, Daniel Strbian, Patrick F. McArdle, Martin Dichgans, Jan H. Veldink, Liisa Tomppo, Arne G. Lindgren, Zhengming Chen, Chikashi Terao, Ulrike Grittner, Marta Ribasés, David R. Weir, James F. Meschia, Sothear Luke, Raquel Rabionet Janssen, Tara M. Stanne, Stephanie Debette, Nicole D. Armstrong, James A. Perry, Julie A. Johnson, Huichun Xu, Christopher D. Anderson, Giorgio B. Boncoraglio, Christian Enzinger, Haley Lopez, Anil Man Tuladhar, Oscar R. Benavente, Veikko Salomaa, David-Alexandre Trégouët, John Danesh, F-E de Leeuw, John Attia, Peter M. Rothwell, Steven J. Kittner, Andreea Ilinca, and Carlos Cruchaga

Subjects
0303 health sciences, medicine.medical_specialty, business.industry, Late onset, Locus (genetics), 030204 cardiovascular system & hematology, medicine.disease, 3. Good health, 03 medical and health sciences, Venous thrombosis, 0302 clinical medicine, ABO blood group system, Internal medicine, Ischemic stroke, medicine, Cardiology, SNP, business, Stroke, 030304 developmental biology, Genetic association
Abstract

ObjectiveTo determine the contribution of common genetic variants to risk of early onset ischemic stroke (IS).MethodsWe performed a meta-analysis of genome-wide association studies of early onset IS, ages 18-59, using individual level data or summary statistics in 16,927 cases and 576,353 non-stroke controls from 48 different studies across North America, Europe, and Asia. We further compared effect sizes at our most genome-wide significant loci between early and late onset IS and compared polygenic risk scores for venous thromboembolism between early versus later onset IS.ResultsWe observed an association between early onset IS and ABO, a known stroke locus. The effect size of the peak ABO SNP, rs8176685, was significantly larger in early compared to late onset IS (OR 1.17 (95% C.I.: 1.11-1.22) vs 1.05 (0.99-1.12); p for interaction = 0.008). Analysis of genetically determined ABO blood groups revealed that early onset IS cases were more likely to have blood group A and less likely to have blood group O compared to both non-stroke controls and to late onset IS cases. Using polygenic risk scores, we observed that greater genetic risk for venous thromboembolism, another prothrombotic condition, was more strongly associated with early, compared to late, onset IS (p=0.008).ConclusionThe ABO locus, genetically predicted blood group A, and higher genetic propensity for venous thrombosis are more strongly associated with early onset IS, compared with late onset IS, supporting a stronger role of prothrombotic factors in early onset IS.

Published
2021

93. Abstract B01: Microphysiological systems as a next-generation precision immunotherapy tool: From patient heterogeneity to memory-like natural killer cells

Author

Catherine A McBain, Mehtab A Farooqui, María Virumbrales-Muñoz, Cristina Sanchez-de-Diego, Sireesh Kumar Teertam, Rebecca Schmitz, Melissa Skala, David J Beebe, and Jose M Ayuso

Subjects
Cancer Research, Immunology
Abstract

Immunotherapy is transforming cancer treatment for thousands of patients worldwide. However, treatment response relies on the patients’ immune system, eliciting heterogeneous results. Numerous parameters contribute to immunotherapy response, including tumor-intrinsic factors such as an immunosuppressive microenvironment characterized by nutrient depletion, acidic pH, or waste products; and tumor-extrinsic factors including genetic immunodeficiencies, or immunosuppressive disorders like HIV infection or organ transplant medication. Consequently, predicting response to immunotherapy remains challenging. Thus, we designed a microphysiological system (MPS) that allows us to incorporate these factors to evaluate patient-specific immunotherapy efficacy. We used our MPS to assess memory-like natural killer (mNK) cell efficacy against solid tumors, as well as evaluated NK cell exhaustion in a tumor-induced suppressive environment. Focusing upon head and neck squamous cell carcinoma (HNSCC), we evaluated risk/benefit ratios and mNK cell responses, including mNK cell extravasation; tumor penetration/killing; and synergy with therapeutic antibodies. We observed that the tumor-induced microenvironment led to gradual erosion of natural killer (NK) cells’ cytotoxicity and upregulation of exhaustion markers. Interestingly, NK cells exhibited a limited capacity to recover from tumor-induced exhaustion, and checkpoint inhibitors and immunomodulatory agents (e.g., PD-1, IDO-1 inhibitors) partially prevented NK cell exhaustion. We also infected T cells with HIV to evaluate whether immunocompromised patients would benefit from mNK cell therapy in the same fashion. In this context, mNK cells exhibited promising immunotherapeutic potential for these populations as they retained tumor killing capacity even in the absence of T cells; mNK cells exhibited extravasation and migration towards patient-derived tumor spheroids, suggesting that mNK cells alone are capable of extravasation. However, CD4 T cells enhanced mNK responses and elicited overexpression of NK survival and function-associated genes, suggesting that future guidelines for people living with HIV and cancer should consider the progression of the disease when considering mNK cell-based therapies. Our MPS may also help to identify CD4 T cell-secreted factors with therapeutic potential to increase mNK cell responses, which could be provided ex vivo in immunocompromised patients. In summary, MPSs offer a precision tool to assess treatment responses in a patient-specific fashion and may help identify next-generation immunotherapies for hitherto excluded cohorts. Citation Format: Catherine A McBain, Mehtab A Farooqui, María Virumbrales-Muñoz, Cristina Sanchez-de-Diego, Sireesh Kumar Teertam, Rebecca Schmitz, Melissa Skala, David J Beebe, Jose M Ayuso. Microphysiological systems as a next-generation precision immunotherapy tool: From patient heterogeneity to memory-like natural killer cells [abstract]. In: Proceedings of the AACR Special Conference: Tumor Immunology and Immunotherapy; 2022 Oct 21-24; Boston, MA. Philadelphia (PA): AACR; Cancer Immunol Res 2022;10(12 Suppl):Abstract nr B01.

Published
2022

94. Studying the Research–Practice Gap in Physical Therapies for Cerebral Palsy: Preliminary Outcomes Based on a Survey of Spanish Clinicians

Author

Cristina Sanchez, Sergio Lerma-Lara, Rodrigo Garcia-Carmona, Eloy Urendes, Paula Laccourreye, and Rafael Raya

Subjects
Equine-Assisted Therapy, Cerebral Palsy, Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health, Humans, cerebral palsy, physical therapies, physiotherapy, occupational therapy, postural control, trunk control, motor control, rehabilitation, survey, clinical practice, scientific evidence, Child, Postural Balance, Professional Practice Gaps, Physical Therapy Modalities
Abstract

The purpose of this work is to study the gap between the research evidence and the clinical practice in the physical rehabilitation of people with cerebral palsy. A review process was performed to (1) identify physical therapies to improve postural control in children with cerebral palsy and (2) determine the scientific evidence supporting the effectiveness of those therapies. A Likert-based survey addressing a total of 43 healthcare professionals involved in pediatric physical therapy departments in Spain was carried out. The discussion was mainly supported by studies of level I or II evidence (according to the Oxford scale). The search process yielded 50 studies reporting 16 therapies. A strong positive correlation between the most used treatments and elevated levels of satisfaction was found. Some well-known but not often used techniques, such as hippotherapy, were identified. The treatment with the highest degree of use and satisfaction—neurodevelopment therapy (Bobath)—and some emerging techniques, such as virtual reality, were also identified. The fact that there is a meaningful gap between clinical practice and the scientific evidence was confirmed. The identified gap brings a certain degree of controversy. While some classic and well-known therapies had poor levels of supporting evidence, other relatively new approaches showed promising results.

Published
2022

97. Sensitivity of Tsunami Scenarios to Complex Fault Geometry and Heterogeneous Slip Distribution: Case‐Studies for SW Iberia and NW Morocco

Author

L. Gómez de la Peña, Eulàlia Gràcia, Francesco Emanuele Maesano, Alessio Piatanesi, Cristina Sanchez Serra, Stefano Lorito, Roberto Basili, Fabrizio Romano, Roger Urgeles, Manuela Volpe, Antonio Scala, Sara Martínez-Loriente, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Serra, C. S., Martinez-Loriente, S., Gracia, E., Urgeles, R., Gomez de la Pena, L., Maesano, F. E., Basili, R., Volpe, M., Romano, F., Scala, A., Piatanesi, A., and Lorito, S.

Subjects
geography, geography.geographical_feature_category, 010504 meteorology & atmospheric sciences, tsunami numerical modeling, Slip (materials science), Fault (geology), 010502 geochemistry & geophysics, 01 natural sciences, heterogeneous slip distribution, Geophysics, 13. Climate action, Space and Planetary Science, Geochemistry and Petrology, complex fault geometry, earthquake, Earth and Planetary Sciences (miscellaneous), tsunami, 14. Life underwater, Sensitivity (control systems), Seismology, Distribution (differential geometry), Geology, seismic and tsunami hazard, 0105 earth and related environmental sciences
Abstract

19 pages, 9 figures, 1 table, supporting information https://doi. org/10.1029/2021JB022127.-- Data Availability Statement: Fault meshes and Slip distributions are available at the figshare repository: https://figshare.com/s/02e19886d2ded8ec9145. MCS data is available at the following published articles: SWIM profiles: Bartolome et al., (2012); Martínez-Loriente (2013); Martínez-Loriente et al., (2013); Martínez-Loriente et al., (2018). VOLTAIRE profiles: Banda et al., (1995); Zitellini et al., (2001); Terrinha et al., (2009). BIGSETS profiles: Zitellini et al., (2001); Zitellini et al., (2004); Vizcaino (2009); Serra et al., (2020). IAM profiles: Sartori et al., (1994); Jiménez-Munt et al., (2010); Terrinha et al., (2009); Zitellini et al., (2009). ARRIFANO profiles: Sartori et al., (1994); Zitellini et al., (2004); Serra et al., (2020). Bathymetry used for the tsunami simulations (Figures 3-7) is available in the SRTM public repository: https://www2.jpl.nasa.gov/srtm/. Detailed bathymetry used to define the fault traces is published in Zitellini et al., 2009. Seismicity data used in Figure 1a is available at the IGN catalog website: https://www.ign.es/web/ign/portal/sis-catalogo-terremotos, The SW Iberian margin is one of the most seismogenic and tsunamigenic areas in W-Europe, where large historical and instrumental destructive events occurred. To evaluate the sensitivity of the tsunami impact on the coast of SW Iberia and NW Morocco to the fault geometry and slip distribution for local earthquakes, we carried out a set of tsunami simulations considering some of the main known active crustal faults in the region: the Gorringe Bank (GBF), Marquês de Pombal (MPF), Horseshoe (HF), North Coral Patch (NCPF) and South Coral Patch (SCPF) thrust faults, and the Lineament South strike-slip fault. We started by considering for all of them relatively simple planar faults featuring with uniform slip distribution; we then used a more complex 3D fault geometry for the faults constrained with a large 2D multichannel seismic dataset (MPF, HF, NCPF, and SCPF); and finally, we used various heterogeneous slip distributions for the HF. Our results show that using more complex 3D fault geometries and slip distributions, the peak wave height at the coastline can double compared to simpler tsunami source scenarios from planar fault geometries. Existing tsunami hazard models in the region use homogeneous slip distributions on planar faults as initial conditions for tsunami simulations and therefore underestimate tsunami hazard. Complex 3D fault geometries and non-uniform slip distribution should be considered in future tsunami hazard updates. The tsunami simulations also support the finding that submarine canyons attenuate the wave height reaching the coastline, while submarine ridges and shallow shelves have the opposite effect, The authors are grateful for funding from MINECO through the project INSIGHT (CTM2015-70155-R), the project STRENGTH (PID2019-104668RB-I00), a MINECO FPI-2016 grant (BES-2016-078877) to Cristina S. Serra (ICM-CSIC), a MICINN “Juan de la Cierva-2017” grant (IJCI-2017-33838) to Sara Martinez-Loriente (ICM-CSIC), and from the Spanish government through the “Severo Ochoa Centre of Excellence” accreditation (CEX2019-000928-S). We acknowledge the resources made available by the SISMOLAB-3D at INGV for the 3D fault modeling

Published
2021

98. New fuzzy RFMD model. A method to identify new customer profiles due to an increase in online activity. Case study of a retail business

Author

Diana Gavilan, Cristina Sanchez Figueroa, Rocio Gonzalez Martinez, and Ramón Alberto Carrasco

Subjects
Economics and Econometrics, Operations research, Computer science, Analytic hierarchy process, Segmentation, Customer lifetime value, Isolation (database systems), Dimension (data warehouse), Duration (project management), Fuzzy logic, Loyalty business model
Abstract

Gaining customer loyalty has become one of the main objectives of all companies. Retailers, especially the online ones, have the advantage of knowing their customers’ historical purchase data, which provides them with an understanding of the customers’ buying patterns. A widely-used tool in strategic marketing and customer loyalty is segmentation based on the traditional Recency, Frequency and Monetary (RFM) model. Subsequently, the fuzzy RFM model proved to be an improvement on the traditional RFM model. There has been a change in the retail customer profile, with the growth of a new cluster, the “One-Shot Customer”, new customers that buy from a retailer just once and never come back. In response to this change, the fuzzy RFM model has been modified to include a new dimension capturing Length or Duration. This study presents the new fuzzy RFMD model (Recency, Frequency, Monetary and Duration model), which can be used to better identify that new, large group of customers. The paper also provides a case study based on an e-commerce clothing retailer. Its customer database was segmented using the k-means algorithm and the Isolation Forest algorithm was applied to identify and correctly treat possible anomalies. The Customer Lifetime Value and the weights for the RFMD attributes were calculated by applying the Analytic Hierarchy Process (AHP) model. Results reveal the improvement that the weighted fuzzy RFMD model offers to retailers, enabling them to detect the One-Shot Customers and thus optimize their strategic marketing plans.

Published
2021

99. Precise measurement of the fs/fd ratio of fragmentation fractions and of Bs0 decay branching fractions

Author

L. Garrido, A. Ustyuzhanin, Loris Martinazzoli, Romanovskiy, Mara Senghi Soares, Jakob Haimberger, J. García Pardiñas, R. Lindner, I. Nasteva, Elisabeth Maria Niel, M. Alexander, Sonia Amina Bouchiba, Y. N. Gao, Yue-tao Yang, Adam Dendek, Patrick Robbe, Anton Poluektov, Lorenzo Sestini, Rafel Manera Escalero, Daniele Marangotto, Anastasia Smetkina, Marie Bachmayer, J. Z. Fan, R. Gomez, Pavol Stefko, E. Govorkova, Harald Viemann, J. H. Lopes, Wenhua Hu, Youen Kang, S. Blusk, Mark Whitehead, Lucas Mcconnell, Artem Ryzhikov, Nis Meinert, Michal Kreps, B. Jost, Phillip John Marshall, Hanna Malygina, Edward Brendan Shields, S. Baker, Wojciech Krzemien, R. Santacesaria, M. J. Charles, A. Davis, Blaise Delaney, Maurice Becker, Laura Promberger, F. J. P. Soler, Z. Xiang, Saverio Mariani, Yuqing Fan, Alessandro Camboni, Fedor Baryshnikov, T. J. V. Bowcock, Anthony Gavin Downes, J. G. Cogan, Songkyo Lee, Paula Alvarez Cartelle, P. Gandini, G. Wilkinson, Alessio Sarti, M. Fiorini, Marco Clemencic, E. M. Gersabeck, Luyan Sun, Mikkel Bjørn, Mark Slater, G. H. Gong, R. Matev, B. Rachwal, Hannah Louise Pullen, C. Matteuzzi, M. Korolev, David Sanchez Gonzalo, Patricia Camargo Magalhaes, Dmitrii Pereima, T. T. H. Pham, Anna Danilina, Claudia Bertella, Francesco Dettori, Rebecca Lane, A. Falabella, Biagio Saitta, Stanislav Luchuk, Serhii Koliiev, Alexandra Paige Rollings, John Leslie Cobbledick, G. Simi, Sara Elizabeth Mitchell, Aleksei Andreianov, Z. Mathe, Alex Seuthe, Robbert Erik Geertsema, Eduard Ursov, Barbara Passalacqua, Mauro Piccini, B. Adeva, Benjamin Audurier, Denis Derkach, F. Ferreira Rodrigues, P. d'Argent, R. McNulty, P. Krokovny, Daniel Berninghoff, C. Haen, P. Griffith, Elisabetta Spadaro Norella, Artem Maevskiy, C. B. Van Hulse, Paolo Ciambrone, Z. Xu, Fedor Ratnikov, A. Hicheur, M. De Serio, D. Lacarrere, C. L. Da Silva, Lukashenko, L. Shekhtman, Jiangqiao Hu, M. N. K. Smith, Salvatore Aiola, Michal Dziewiecki, J. He, Surapat Ek-In, Xixin Liang, S. Easo, Miroslaw Firlej, Chun-wei Gu, Lauren Emma Yeomans, P. Campana, Thomas Peter Jones, Mikhail Mikhasenko, Andrea Bizzeti, M. McCann, Carina Trippl, Andrea Lampis, Ryan Newcombe, Evgenii Shmanin, Paula Garcia Moreno, Jan Langer, Agnieszka Oblakowska-Mucha, A. I. McNab, Obraztsov, Sandra Amato, Petr Andreevich Gorbounov, Giulia Tuci, Lag Cardoso, Alexander Malinin, Pablo Baladron Rodriguez, Zhuoming Li, Jonathan Plews, Matthew John Bradley, Xabier Cid Vidal, Luca Minzoni, Michela Garau, Kirsebom, Maksim Karpov, Gianluigi Casse, Angelo Loi, Balagura, P. De Simone, E. Jans, M.I. Williams, Daniel Joachim Unverzagt, Srishti Bhasin, M. S. Rangel, Liupan An, X. Han, P. Marino, Roberta Cardinale, Sara Sellam, Abraham Gallas Torreira, Martina Ferrillo, Carlos Abellán Beteta, B. Spaan, W. Huang, Melissa Maria Cruz Torres, Ettore Zaffaroni, K. Wyllie, S. G. Weber, L. Zhang, W. Funk, B. Pietrzyk, A. Massafferri, Zhuyin Ren, Sergey Legotin, William Barter, Martina Pili, K. Belous, Jolanta Brodzicka, S. L. Yang, S. Gambetta, Jana Crkovská, Aleksandra Snoch, Zishuo Yang, C. Gaspar, M. Palutan, M. J. Morello, P. Perret, Sergey Barsuk, Ruiting Ma, Oliver Lantwin, A. Valassi, François Fleuret, B. Leverington, D. Yang, M. Chrzaszcz, L. Giubega, Aleksandr Solovev, Lucian Cojocariu, O. Leroy, J. Maratas, A. Bertolin, Jose Maria Fernandez-tenllado Arribas, P. Roloff, Aleksei Chernov, K. E. Kim, Amanda May Donohoe, K. De Bruyn, F. Polci, Jakub Ryzka, J. Closier, Davide Brundu, C. Patrignani, M. Andreotti, Marianna Fontana, Roel Aaij, Sergei Popov, E. Graverini, Paolo Carniti, Meril Reboud, J. Dalseno, Tatiana Ovsiannikova, Alexander Berezhnoy, Arthur Marius Hennequin, A. Petrolini, Marco Petruzzo, D. Vieira, I. Polyakov, Miroslav Saur, Carmen Giugliano, M. Karacson, Qundong Han, Donal Murray, A. Bay, B. T. Meadows, Biljana Mitreska, Holger Stevens, Monica Pepe Altarelli, Y. Zhou, Cheryl Pappenheimer, Lais Soares Lavra, M. Merk, Y. H. Zheng, C. J. G. Onderwater, Alexander Inglessi, A. B. Rodrigues, Bartosz Malecki, Roland Bernet, Juan Jose Saborido Silva, Mikhail Zavertyaev, Placido Fernandez Declara, Roberto Ribatti, M. Shapkin, Qianfan Xu, Davide Fazzini, T. Ruf, Y. Li, Hang Yin, Michael Brodski, Heather Mckenzie Wark, G. Lanfranchi, M.-N. Minard, Paul Nathaniel Swallow, M. Frank, Abbie Jane Chadwick, T. Kvaratskheliya, M. Tobin, David Anthony Friday, A. Lusiani, A. Bitadze, Brij Kishor Jashal, E. Dall'Occo, Krzysztof Swientek, Lorenzo Pica, Jevtic, G. Raven, D. Decamp, A. Golutvin, M. D. Sokoloff, Olga Madejczyk, Franco Bedeschi, A. Oyanguren, Juan Martin Otalora Goicochea, Laurent Dufour, B.R. Gruberg Cazon, Stefano Cali, Dana Bobulska, A. Vorobyev, Marek Jezabek, F. Dordei, P. Naik, M. Kucharczyk, T. Gys, Gediminas Sarpis, Matthew Scott Rudolph, N. Tuning, Marian Stahl, Naomi Veronika Raab, D. Savrina, Chulikov, P. Ilten, Ross John Hunter, A. Gomes, Federico Betti, Huagang Liu, Simone Capelli, Stanislav Poslavskii, A. Palano, Tomasz Szumlak, Jairo Alexis Rodriguez Lopez, David Gerick, Mauricio Féo, E. Santovetti, Dmitry Golubkov, Kudryavtsev, Maciej Wojciech Dudek, Tatiana Gaintseva, Pierre Billoir, Mario Edgardo Olivares, Rui Wang, Dobishuk, A. Buonaura, Sergio Gomez Fernandez, Da Yu Tou, F. Teubert, Alessandra Gioventù, M. Rotondo, Serhii Cholak, Renata Kopecna, D. R. Muller, John Matthew Durham, Vorobyev, N. Neri, Z. Wang, Lucio Anderlini, Vagnoni, Oscar De Aguiar Francisco, Ivan Solovyev, Jakub Moron, Kodassery Prasanth, W. Baldini, L. Bian, Henryk Karol Giemza, Fernanda Goncalves Abrantes, P. Di Nezza, Svende Braun, S. Klaver, Nikolai Voropaev, R. Schwemmer, O. Maev, Alexandre Brea Rodriguez, A. Alfonso Albero, Konrad Klimaszewski, Cibran Santamarina Rios, C. Chen, Kurt Rinnert, P. Spradlin, Pere Gironella Gironell, Dong Xiao, Sebastian Bachmann, M. J.J. John, Milosz Zdybal, L. Grillo, Christopher Betancourt, Martino Borsato, Pablo Vazquez Regueiro, G. Ciezarek, A. Leflat, R. S Coutinho, R. Jacobsson, Rafal Dominik Krawczyk, C. Gotti, J. F. Marchand, Anatoly Konoplyannikov, Maciej Pawel Szymanski, M. Pappagallo, M. Rama, F. Fontanelli, Michele Veronesi, A. Vollhardt, Marco Guarise, Lisovskyi, F. Muheim, Philippe Ghez, G. Wormser, Ming Zeng, Tommaso Pajero, Ina Carli, Stephan Eisenhardt, Andrea Merli, Jacopo Cerasoli, Jakub Jacek Malczewski, Dmitrii Maisuzenko, Hans Dijkstra, Zakariya Aliouche, D. Pinci, M. Vesterinen, C. Langenbruch, G. Haefeli, X. Huang, Maxim Borisyak, G. Alkhazov, P. Durante, John Gordon Smeaton, Christopher John Parkinson, M. Veltri, Giacomo Vitali, Louis Lenard Gerken, Eva Vilella Figueras, Stephan Escher, Jennifer Clare Smallwood, S. Filippov, Xiaofeng Zhu, A. Papanestis, Yuyue Gan, Anatoly Butkevich, Guillaume Pietrzyk, Adrián Casais Vidal, Minaugas Sarpis, Danila Saranin, A. Grecu, Andrii Usachov, H. Cai, Serena Maccolini, A.E. Bondar, T. M. Evans, E. van Herwijnen, Patrick Koppenburg, B. D. C. Westhenry, J. J. Back, F. Maciuc, Mikhail Hushchyn, T. J. Harrison, Sandro Cadeddu, Georgios Chatzikonstantinidis, Samuel Maddrell-Mander, Miguel Ramos Pernas, A. Bursche, M. Ferro-Luzzi, L. L. Pappalardo, D. Melnychuk, Alexsei Chubykin, Tommaso Colombo, Mateusz Goncerz, Davide Zuliani, Piera Muzzetto, Sune Jakobsen, A. Zhelezov, Patrick Mackowiak, Barbara Sciascia, Bo Fang, Boris Quintana, Jordan Daniel Roth, Hossein Afsharnia, G. Carboni, Macko, G. Punzi, Lex Marinus Greeven, Beatriz Garcia Plana, Abhijit Mathad, Matthew George Chapman, D. C. Craik, Yawen Wang, G. Valenti, Oscar Boente Garcia, Fanghua Jiang, Emilie Maurice, Martha Hilton, Quentin Fuehring, D. E. Hutchcroft, Pugatch, Pascal Vincent, R. Waldi, Marcel Materok, Niladribihari Sahoo, O. Yushchenko, S. Ricciardi, Philippe Charpentier, Yuezhe Yao, Christoph Frei, Rizwaan Adeeb Mohammed, Cynthia Nunez, Julian Lomba Castro, Duk, S. Eidelman, Gennady Panshin, Mariia Poliakova, Mick Mulder, M. Adinolfi, Kuzma Ivshin, P. Owen, Kristian Alexander Zarebski, Ekaterina Trifonova, Joan Mauricio, Thomas Henry Hancock, M. van Veghel, D. Zhang, X. K. Zhou, T. E. Latham, B. Dey, W. Kucewicz, Fidan Suljik, F. Blanc, R. Lefèvre, Fabrice Desse, Y. Xie, Kevin Heijhoff, Lorenzo Capriotti, Stephane T'Jampens, Alessandro Pastore, B. Khanji, Anne Robert, W. Parker, Philipp Ibis, Fernando Martinez Vidal, Jiayin Sun, A. Lai, Andrea Mauri, A. Pearce, Jordy Sebastiaan Butter, Sara Celani, Elisabet Golobardes, M. Van Dijk, Thomas Blake, Evangelos Leonidas Gkougkousis, Anna Lupato, G. Graziani, J. Wang, Jennifer Brigitta Zonneveld, Aravindhan Venkateswaran, Maximilien Chefdeville, Carmelo D'Ambrosio, Oleg Stenyakin, C. Fitzpatrick, C. A. Aidala, Tamaki Holly Mcgrath, B. De Souza Paula, A. Jawahery, Diego Torres Machado, G. Mancinelli, Sergey Didenko, George Holger Lovell, D. De Simone, Dmitry Popov, Sophie Katharina Kretzschmar, Antonino Sergi, T. Boettcher, Simone Bifani, Guoming Liu, Dmitrii Ilin, Lima, H. Schindler, Marek Idzik, D. R. Johnson, Maciej Witold Majewski, Fionn Caitlin Ros Bishop, Stefano Zucchelli, L. Del Buono, C. R. Jones, Roman Litvinov, Marco Cattaneo, Manuel Franco Sevilla, G. Corti, Murdo Traill, Halime Sazak, Alexandre Boyer, E. Ben-Haim, Edward James Millard, Marco Gersabeck, Nikita Kazeev, I. V. Gorelov, K. Müller, Giovanni Bassi, Colm Harold Murphy, D. Websdale, Li Li, Manuel Schiller, B. Couturier, R. A. Fini, Martin Stefan Bieker, Lauren Douglas, T. Nakada, Marcos Romero Lamas, Renato Quagliani, Razvan Daniel Moise, Thomas Hadavizadeh, Belavin, Christoph Hasse, G. Passaleva, Christopher James Pawley, Lukas Calefice, Christopher Burr, Maria Elena Stramaglia, C. Göbel, Zhihong Shen, S. Schael, Wojciech Krupa, Gary Robertson, Sergey Gromov, Kazuyoshi Carvalho Akiba, T. Skwarnicki, Bhagyashree Pagare, Xia-Ji Liu, D. Hill, Louis Henry, Hilbrand Steffen Kuindersma, E. Smith, Tomasz Fiutowski, E. Grauges, F. Machefert, P. Collins, Y. Sun, Gerwin Meier, S. Kandybei, J. A. B. Coelho, J. Albrecht, Artur Ishteev, T. Kirn, C. A. Chavez Barajas, Silvia Ferreres Sole, Federico Redi, C. Parkes, H.-P. Dembinski, P. R. Li, A. Dziurda, Neville Harnew, M. De Cian, M. van Beuzekom, Scott Ely, Lars Eklund, Leon David Carus, Eliane Epple, Ziad Ajaltouni, Liliet Calero Diaz, Gianluca Zunica, Michele Piero Blago, Anton Philippov, Nicola Serra, Andrew Beiter, Andreas Güth, P. Seyfert, Margarete Schellenberg, Peter Svihra, U. Marconi, F. F. Wilson, T. D. Nguyen, Sergei Kholodenko, N. Sagidova, O. Zenaiev, Maurizio Martinelli, S. Borghi, Li Xu, Bellee, Giulia Frau, Lishuang Ma, S. De Capua, Nikolay Nikitin, P. E. L. Clarke, Sebastien Ponce, Kayleigh Anne Thomson, Daniele Manuzzi, A. C. dos Reis, Alexander Vagner, Cedric Meaux, L. Tomassetti, Adam Szabelski, A. Ukleja, Simon Stemmle, Edoardo Franzoso, Antonio Pellegrino, Frank Ferrari, E. Polycarpo, G. Bencivenni, Michele Atzeni, Moran Wang, S. Tolk, Preema Rennee Pais, Jixing Qin, I. Longstaff, S. Vecchi, Shishu Zhang, M. Milovanovic, Alessio Piucci, Yasmine Amhis, Gabriela Johanna Pomery, Matteo Giovannetti, M. Morandin, Alexey Boldyrev, M. H. Schune, U. Uwer, Liliana Congedo, Tjeerd Ketel, J. Fu, Tara Nanut, Carlos Vázquez Sierra, C. Prouve, H. V. Cliff, Federico Alessio, Daria Strekalina, Gligorov, Maria Vieites Diaz, Xavier Vilasis-Cardona, M. Patel, Anastasiia Kharisova, Federico Lazzari, N. K. Watson, Raul Iraq Rabadan Trejo, James Vincent Mead, O. Lupton, M. T. Tran, U. Egede, M.F. Cicala, Igor Slazyk, Clara Remon Alepuz, I. A. Monroy, D. Wiedner, Egorychev, Angel Fernando Campoverde Quezada, G. Cavallero, Hangyi Wu, Mark Hatch, Olivier Deschamps, Niklas Stefan Nolte, Flavio Archilli, Lakshan Ram Madhan Mohan, Yue Pan, Johannes Heuel, Ying Lu, T. J. Gershon, Renaudin, Sebastian Schulte, Elie Aslanides, Mark Wilkinson, T. G. Shears, Nikolay Bondar, Timofei Maltsev, Simon Nieswand, S. Simone, J. J. Xu, Karlis Dreimanis, R. Calabrese, Matthieu Marinangeli, Sophie Elizabeth Hollitt, A. Sciubba, S. J. Chen, A. Satta, Lorena Dieste Maronas, D. A. Milanes, Simone Meloni, C. Nguyen-Mau, Anna Ossowska, Nathan Jurik, J. Marks, Thomas Ackernley, Chobanova, Antje Mödden, D. Lucchesi, J. A. de Vries, M. Straticiuc, Ho Ling Li, R. Nandakumar, Kevin Heinicke, Diego Martinez Santos, Kara Renee Mattioli, M. Schmelling, Tisserand, C. Satriano, S. Perazzini, Alexey A. Petrov, A. Contu, Joseph David Shupperd, Felipe Andres Garcia Rosales, Polina Kravchenko, S. Farry, B. Schmidt, F. M. L. de Almeida, Antonio Fernandez Prieto, Ivan Belyaev, E. Rodrigues, L. De Paula, Baasansuren Batsukh, Felix Johannes Kress, Shantam Taneja, Jan-Marc Basels, A. Artamonov, L. C Garcia, Juan Baptista Leite, R. Le Gac, Michal Kazimierz Mazurek, Matthew James Tilley, M. Witek, W. Qian, M. Needham, S. Stone, Ouail Kitouni, M. Gandelman, E. Gushchin, A. Dzyuba, Harris Conan Bernstein, C. Bozzi, Samuel Belin, Constantin Weisser, N. G. Polukhina, A. Semennikov, Matthew Birch, Igor Kostiuk, Jiesheng Yu, Konstantin Gizdov, Wiktor Byczynski, Stephane Monteil, Ricardo Graciani Diaz, R. J. Barlow, Yury Guz, Shuaiyi Liu, A. Dovbnya, J. J. Walsh, Davide Lancierini, Daniel Patrick O'Hanlon, Marta Calvi, Paul Andre Günther, Dipanwita Dutta, G. D. Lafferty, Iaroslava Bezshyiko, Ivan Shchemerov, Angelo Carbone, Jaap Velthuis, Florian Reiss, S. Malde, Jonas Nathanael Eschle, Maxime Schubiger, Kamil Leszek Fischer, Maitreyee Mukherjee, Luis Miguel Garcia Martin, D. J. White, Ignacio Bediaga, Desmond Mzamo Shangase, Ilia Belov, S. Esen, Marco Poli Lener, Marco Santimaria, Jonas Rademacker, R. Currie, S. Hansmann-Menzemer, Gerd Joachim Kunde, A. Schopper, Jozef Tomasz Borsuk, Stephen M. Stahl, N. Neufeld, Oleksander Kot, R. Mountain, Sofia Kotriakhova, Jihyun Bhom, Alison Tully, Dorothea Vom Bruch, T. Lesiak, G. Manca, O. Schneider, Alexandru Ene, E. Thomas, M. Xu, Matteo Bartolini, Karol Hennessy, L. Kravchuk, Alessandro Cardini, Roger Forty, Chishuai Wang, J. M. De Miranda, A.B. Morris, N. Skidmore, Dominik Stefan Mitzel, Alexander Battig, Gianfranco Morello, Pawel Kopciewicz, Lukas Witola, Lino Ferreira Lopes, Nuria Valls Canudas, Joan Ruiz Vidal, Miriam Lucio Martinez, E. Luppi, Cmc Sobral, Ifan Williams, Y. Zhang, F. Stagni, Hongjie Mu, Zhukov, Francesca M. Pisani, Phoebe Meredith Hamilton, Matiunin, Jan Buytaert, Arnau Brossa Gonzalo, Julian Alexander Boelhauve, Emmy Gabriel, Gibson, Benedetto Gianluca Siddi, Jascha Peter Grabowski, S. Neubert, Yiheng Luo, Stefano Petrucci, Kenenbek Arzymatov, Cameron Thomas Dean, O. Steinkamp, Aiguo Xu, Ryan Calladine, Floris Keizer, Lesya Shchutska, E. Cogneras, Maximo Plo Casasus, S. A. Wotton, John Jake Lane, Rudolf Oldeman, Miriam Calvo Gomez, Carla Marin Benito, Ilaria Neri, Denysenko, Xiao-Rui Lyu, Cristina Sanchez Gras, Matthew Kenzie, Dawid Gerstel, Malte Hecker, Placinta, Almagul Kondybayeva, Tai-Hua Lin, D. Hynds, D. Galli, Marina Artuso, W. Wislicki, George Coombs, Titus Mombächer, Thomas Grammatico, G. Martellotti, Petr Fedin, W. D. Hulsbergen, Konstantinos Petridis, Luke George Scantlebury Smead, Tabitha Halewood-leagas, Simon Akar, Naomi Cooke, and X. Yuan

Subjects
Physics, Linear function (calculus), Large Hadron Collider, Meson, 010308 nuclear & particles physics, Branching fraction, Physics beyond the Standard Model, Tsallis statistics, Function (mathematics), 01 natural sciences, Bottom quark, Nuclear physics, 0103 physical sciences, High Energy Physics::Experiment, Nuclear Experiment, 010306 general physics
Abstract

The ratio of the B s 0 and B 0 fragmentation fractions, f s / f d , in proton-proton collisions at the LHC, is obtained as a function of B -meson transverse momentum and collision center-of-mass energy from the combined analysis of different B -decay channels measured by the LHCb experiment. The results are described by a linear function of the meson transverse momentum or with a function inspired by Tsallis statistics. Precise measurements of the branching fractions of the B s 0 → J / ψ ϕ and B s 0 → D s - π + decays are performed, reducing their uncertainty by about a factor of 2 with respect to previous world averages. Numerous B s 0 decay branching fractions, measured at the LHCb experiment, are also updated using the new values of f s / f d and branching fractions of normalization channels. These results reduce a major source of systematic uncertainty in several searches for new physics performed through measurements of B s 0 branching fractions.

Published
2021

100. An RFM Model Customizable to Product Catalogues and Marketing Criteria Using Fuzzy Linguistic Models: Case Study of a Retail Business

Author

Diana Gavilan, Cristina Sanchez-Figueroa, Rocio Gonzalez Martinez, and Ramón Alberto Carrasco

Subjects
Knowledge management, Computer science, Process (engineering), AHP, k-means, General Mathematics, 2-tuple RFM model, Analytic hierarchy process, fuzzy linguistic modelling, product catalogue management, Field (computer science), Market segmentation, 0502 economics and business, Computer Science (miscellaneous), QA1-939, Product (category theory), Engineering (miscellaneous), Interpretability, Marketing, customer segmentation, PCA, Hierarchy, business.industry, 05 social sciences, customer loyalty in retail, Ticket, multicriteria decision making, 050211 marketing, RFM model, business, 050203 business & management, Mathematics
Abstract

In the field of strategic marketing, the recency, frequency and monetary (RFM) variables model has been applied for years to determine how solid a database is in terms of spending and customer activity. Retailers almost never obtain data related to their customers beyond their purchase history, and if they do, the information is often out of date. This work presents a new method, based on the fuzzy linguistic 2-tuple model and the definition of product hierarchies, which provides a linguistic interpretability giving business meaning and improving the precision of conventional models. The fuzzy linguistic 2-tuple RFM model, adapted by the product hierarchy thanks to the analytical hierarchical process (AHP), is revealed to be a useful tool for including business criteria, product catalogues and customer insights in the definition of commercial strategies. The result of our method is a complete customer segmentation that enriches the clusters obtained with the traditional fuzzy linguistic 2-tuple RFM model and offers a clear view of customers’ preferences and possible actions to define cross- and up-selling strategies. A real case study based on a worldwide leader in home decoration was developed to guide, step by step, other researchers and marketers. The model was built using the only information that retailers always have: customers’ purchase ticket details.

Published
2021

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