278 results on '"Cristina Campoy"'
Search Results
52. Métodos de introducción de alimentación complementaria en el primer año de vida
- Author
-
Cristina Campoy and Rosaura Leis
- Subjects
Pediatrics, Perinatology and Child Health - Published
- 2023
53. The Effect of Consumer Concern for the Environment, Self-Regulatory Focus and Message Framing on Green Advertising Effectiveness: An Eye Tracking Study
- Author
-
Myriam Martínez-Fiestas, Ana Nieto-Ruiz, Cristina Campoy, Francisco Muñoz-Leiva, Francisco Liébana-Cabanillas, and Diego Gómez-Carmona
- Subjects
Regulatory focus theory ,Eye tracking ,Advertising ,Message framing ,Business ,Management, Monitoring, Policy and Law ,Environmental Science (miscellaneous) ,Green advertising - Abstract
The aims of the present study were: (a) to analyze the advertising message of renewable energies using eye-tracking technology, based on differences in the level of attention captured according to ...
- Published
- 2021
54. Gut microbiota in obesity and related comorbidities in children and adolescents: the role of biotics in treatment
- Author
-
Giulia FIORE, Vittoria C. MAGENES, Elisabetta DI PROFIO, Chiara MILANTA, Valeria CALCATERRA, Antonella DIAMANTI, Cristina CAMPOY, Gianvincenzo ZUCCOTTI, and Elvira VERDUCI
- Subjects
Pediatrics, Perinatology and Child Health - Abstract
Obesity is a complex pathology, globally spread, with a multifactorial pathogenesis, strictly linked with lifestyle, hormones, genetic and epigenetic factors. Evidence supports that obesity, and its comorbidities, are related to changes in gut microbiota, partially responsible of the modulation of energy metabolism.Pediatric obesity has been associated with lower bacterial diversity and differences in composition of the gut microbiota, also varying according to the metabolic status of obese subjects. Indeed, differences in distributions and activity of microorganisms in the gut of metabolically healthy and unhealthy obese children have been highlighted.Based on human studies, this review aims to discuss gut microbiota alterations in obese children and adolescents and its role in obese-related complications. Moreover, the role of biotics (probiotics, prebiotics, synbiotics and -marginally- postbiotics) has been analyzed as modulator of obesity-related dysbiosis.As a conclusion, a deeper knowledge about biotic mechanisms of action would be of great interest to implement the clinical care of children and adolescents with obesity and related comorbidities.
- Published
- 2022
55. Documentation of Functional and Clinical Effects of Infant Nutrition : Setting the Scene for COMMENT
- Author
-
Koletzko, Berthold, Szajewska, Hania, Ashwell, Margaret, Shamir, Raanan, Aggett, Peter, Baerlocher, Kurt, Noakes, Paul, Braegger, Christian, Calder, Philip, Folgoso, Cristina Campoy, Colomb, Virginie, Decsi, Tamás, Domellöf, Magnus, Dupont, Christophe, Fewtrell, Mary, van Goudoever, Johannes B., Michaelsen, Kim F., Mihatsch, Walter, Guarino, Alfredo, Koletzko, Sibylle, Rigo, Jacques, Turck, Dominique, and Taminiau, Jan
- Published
- 2012
56. Impact of gut microbiota on neurogenesis and neurological diseases during infancy
- Author
-
Tomás Cerdó, Cristina Campoy, and Estefanía Diéguez
- Subjects
0301 basic medicine ,Neurogenesis ,Central nervous system ,Gut flora ,Bioinformatics ,030226 pharmacology & pharmacy ,03 medical and health sciences ,0302 clinical medicine ,Gut bacteria ,Drug Discovery ,Animals ,Humans ,Medicine ,Microbiome ,Pharmacology ,Window of opportunity ,Gastrointestinal tract ,biology ,business.industry ,Infant, Newborn ,Brain ,biology.organism_classification ,Gastrointestinal Microbiome ,030104 developmental biology ,medicine.anatomical_structure ,Nervous System Diseases ,business - Abstract
The first years of life constitute a crucial period for neurodevelopment and a window of opportunity to develop new strategies to prevent neurological and mental diseases. Different studies have shown the influence of gut bacteria in neurogenesis and a functional relationship between gut microbiota and the brain, known as 'gut-brain axis', in which the intestinal microbiota is proposed to play a key role in neurophysiological processes. It has been observed that certain microbiome metabolites could be related to the development of neurological disorders through mechanisms still unknown. Then, more studies are needed to broaden the knowledge regarding the relationship between the Central Nervous System and the gastrointestinal tract, which could help to develop new preventive and treatment protocols.
- Published
- 2020
57. A synbiotics, long chain polyunsaturated fatty acids, and milk fat globule membranes supplemented formula modulates microbiota maturation and neurodevelopment
- Author
-
Tomás Cerdó, Alicia Ruíz, Inmaculada Acuña, Ana Nieto-Ruiz, Estefanía Diéguez, Natalia Sepúlveda-Valbuena, Mireia Escudero-Marín, Jose Antonio García-Santos, María García-Ricobaraza, Florian Herrmann, Jose Antonio Moreno-Muñoz, Roser De Castellar, Jesús Jiménez, Antonio Suárez, and Cristina Campoy
- Subjects
Nutrition and Dietetics ,Microbiota ,Fatty Acids ,Neurodevelopment ,Infant ,Synbiotics ,Lipid Droplets ,Gut microbiota ,Critical Care and Intensive Care Medicine ,Infant Formula ,Breast Feeding ,Enterotypes ,Fatty Acids, Unsaturated ,Infant formula ,Humans ,Female ,Glycolipids ,Glycoproteins - Abstract
Supplementary data to this article can be found online at https://doi.org/10.1016/j.clnu.2022.05.013., Acknowledgments The authors wish to acknowledge the parents and children who participated in the study, and also the paediatricians and researchers of the EURISTIKOS team at the Department of Paediatrics as well as the Genetics Service at Centro de Instrumentación Científica e UGR for their contributions., Funding This project was supported by CDTI (Centro para el Desarrollo Tecnológico e Industrial) and FEDER (SMARTFOODS: IDI-20141206), Ordesa Laboratories, S.L. (Contract FE-UGR No. 3349), and The Spanish Ministry of Economy, Industry and Competitiveness, and partially supported by HORIZON 2020 EU DynaHEALTH Project (GA No.633595). Alicia Ruiz and Inmaculada Acuña were granted Ph.D. scholarships from the Spanish Ministry of Economy and Competitivity. Tomás Cerdó was granted a Ph.D. scholarship from Carlos III Health Institute. Natalia Sepúlveda-Valbuena was granted with a scholarship from Fundación Carolina, Madrid, Spain., Background & aims The critical window of concurrent developmental paths of the nervous system and gut microbiota in infancy provides an opportunity for nutritional interventions with potential health benefits later in life. Methods We compared the dynamics of gut microbiota maturation and explored its association with neurodevelopment at 12 months and 4 years of age in 170 full-term healthy infants fed a standard formula (SF) or a new formula (EF) based on standard formula supplemented with synbiotics, long chain polyunsaturated fatty acids (LC-PUFA) and bovine milk fat globule membranes (MFGM), including a breastfed reference group (BF). Results Using Dirichlet Multinomial Modelling, we characterized three microbial enterotypes (Mixed, anaerobic and aerobic profile; Bact, Bacteroides-dominant; Firm, Firmicutes-enriched) and identified a new enterotype dominated by an unidentified genus within Lachnospiraceae (U_Lach). Enterotypes were associated with age (Mixed with baseline, U_Lach with month 6, Bact and Firm with months 12 and 18). Trajectories or timely enterotype shifts in each infant were not random but strongly associated with type of feeding. Trajectories in SF shifted from initial Mixed to U_Lach, Bact or Firm at month. Microbiota maturation in EF split into a fast trajectory as in SF, and a slow trajectory with Mixed to U_Lach, Bact or Firm transitions at months 12 or 18, as in BF. EF infants with slow trajectories were more often in–home reared and born by vaginal delivery to mothers with pre-pregnancy lean BMI. At 12 months of age, language and expressive language scores were significantly higher in EF infants with fast trajectories than in BF. Neurodevelopmental outcomes were similar between EF infants with slow trajectories and BF at 12 months and 4 years of age. Conclusions Feeding a synbiotics, LC-PUFA and MFGM supplemented formula in a specific infant environment promoted probiotic growth and retarded gut microbiota maturation with similar neurodevelopment outcomes to breastfed infants., CDTI (Centro para el Desarrollo Tecnológico e Industrial) and FEDER (SMARTFOODS: IDI- 20141206), Ordesa Laboratories, S.L. (Contract FE-UGR No. 3349), Spanish Ministry of Economy, Industry and Competitiveness, HORIZON 2020 EU DynaHEALTH Project (GA No.633595)
- Published
- 2022
58. Infant growth, neurodevelopment and gut microbiota during infancy
- Author
-
Estefanía Diéguez, Cristina Campoy, and Tomás Cerdó
- Subjects
0301 basic medicine ,chemistry.chemical_classification ,030109 nutrition & dietetics ,Nutrition and Dietetics ,Milk, Human ,Infant ,Oligosaccharides ,Medicine (miscellaneous) ,030208 emergency & critical care medicine ,Nutrients ,Biology ,Gut flora ,biology.organism_classification ,Gastrointestinal Microbiome ,03 medical and health sciences ,Child Development ,0302 clinical medicine ,Nutrient ,chemistry ,Humans ,Food science ,Polyunsaturated fatty acid - Abstract
To update the role of specific nutrients during infant development.Several bioactive nutrients such as long-chain polyunsaturated fatty acids (LC-PUFAs), iron, vitamins, proteins, or carbohydrates have been identified to exert an important role during the first 1000 days of life on infant growth, neurodevelopment, and gut microbiota establishment and maturation. LC-PUFAs are structural constituents of the central nervous system (CNS), being essential in retinal development or hippocampal plasticity. Recently, components of the milk fat globule membrane (MFG) are being added to infant formulas because of their key role in infant's development. A high intake of proteins induces a faster weight gain during infancy which correlates with later obesity. Digestible carbohydrates provide glucose, crucial for an adequate functioning of CNS; nondigestible carbohydrates [e.g. human milk oligosaccharides (HMOs)] are the main carbon source for gut bacteria. Iron-deficiency anemia during infancy has been associated with alterations of mental and psychomotor development. Folate metabolism, closely related to vitamins B6 and B12, controls epigenetic changes, whereas inadequate status of vitamin D affects bone development, but may also increase intestinal permeability and alter gut microbiota composition.LC-PUFAs, proteins, carbohydrates, iron, and vitamins during early life are critical for infant's growth, neurodevelopment, and the establishment and functioning of gut microbiota.
- Published
- 2019
59. [Controversy about the critical role of long-chain polyunsaturated fatty acids, arachidonic acid (ARA) and docosahexaenoic acid (DHA), during infancy]
- Author
-
Cristina, Campoy, Aida Maribel, Chisaguano Tonato, Andrea, de la Garza Puentes, Miguel, Sáenz de Pipaón, Elvira, Verduci, Berthold, Koletzko, Inés, González Casanova, Elvira, Larqué, Rodrigo, Valenzuela, José Manuel, Moreno Villares, and Ángel, Gil
- Subjects
Male ,Docosahexaenoic Acids ,Milk, Human ,Dietary Supplements ,Fatty Acids, Unsaturated ,Infant, Newborn ,Humans ,Infant ,Female ,Infant Food ,Arachidonic Acids ,Infant Nutritional Physiological Phenomena - Abstract
Long-chain polyunsaturated fatty acids (LC-PUFAs) are critical for infant growth and development, particularly arachidonic acid (ARA, C20:4n-6) and docosahexaenoic acid (DHA, C22:6n-3). ARA and DHA are components of cell membrane phospholipids and play an important role in cell division, differentiation, and signaling; and DHA is the n-3 fatty acid predominant in the developing brain and retina. During the third trimester of pregnancy, LC-PUFAs increase substantially in fetal circulation, and a "biomagnification" process in the fetal brain is observed. Moreover, LC-PUFAs are precursors of eicosanoids and metabolites, which modulate the intensity and duration of the immune response. LC-PUFA synthesis implies complex desaturation and elongation processes on their principal precursors, linoleic acid (LA) (18:3 n-6) (series n-6) and α-linolenic acid (LNA) (20:3 n-3) (series n-3), where fatty acid desaturases (FADS) and elongases (ELOVL) are competing. It is important to notice that during the first months of life, as a consequence of low enzymatic activity, LC-PUFA synthesis from LA and LNA is reduced, especially in those infants carrying variations in the FADS and ELOVL genes, which are involved in LC-PUFA synthesis, and so they are unable to supply their own DHA and ARA needs. Homozygote infants for FADS haplotype A (97 % of the Latinoamerican population) show low levels of ARA (only 43 %) and DHA (only 24 %) when compared to those carrying haplotype D (more prevalent in Europe, Africa and Asia). Human milk is the only source of LA, LNA, ARA, and DHA for the neonate and infant till complementary feeding (CF) is introduced. Infants fed with infant formulas must receive enough amounts of LA, LNA, ARA, and DHA to cover their nutritional requirements. The new guidelines by the European Food Safety Authority (EFSA) (2016) recommend that infant formulas and follow-on formulas must contain 20-50 mg of DHA/100 kcal (0.5-1 % of total fatty acids, which is higher than in human milk and the majority of infant formulas in the market), and it is not necessary to add ARA. This new regulation, which is already applicable since February 2020, has resulted in profound controversy because there is no scientific evidence about its appropriateness and safety for healthy children. Then, different international expert groups have revised the research already published about the effects of ARA and DHA addition to infant formulas, and discussed different emerging questions from this European directive. The expert group led from the University of Granada (Spain) recommends the addition of ARA in similar or higher concentrations than those of DHA, at least equal to those present in human milk (0.3 % of total fatty acids), although preferably 0.5 % and up to around 0.64 % of total fatty acids, since new studies confirm the optimal intake of ARA and DHA during the different developmental stages. This recommendation could be of particular importance for infants carrying the haplotype A of FADS.Los ácidos grasos poliinsaturados de cadena larga (AGPI-CL) son críticos para el crecimiento y desarrollo infantil, en particular los ácidos araquidónico (ARA, C20:4n-6) y docosahexaenoico (DHA, C22:6n-3). El ARA y el DHA son componentes de los fosfolípidos de las membranas celulares y desempeñan importantes funciones en la división, diferenciación y señalización celular, siendo el DHA el ácido graso de la serie n-3 predominante en el cerebro y la retina en desarrollo. Durante el tercer trimestre de la gestación, los AGPI-CL aumentan de forma sustancial en la circulación fetal, observándose un proceso de “biomagnificación” en el cerebro fetal. Además, los AGPI-CL son precursores de los eicosanoides y metabolitos implicados en la modulación de la intensidad y duración de la respuesta inmunitaria. La síntesis de AGPI-CL implica un complejo proceso de desaturación y elongación desde los precursores principales, el ácido linoleico (18:3 n-6) (LA) (serie n-6) y el ácido α-linolénico (20:3 n-3) (LNA) (serie n-3), por los cuales compiten las enzimas desaturasas (FADS) y elongasas (ELOVL). Es importante indicar que en los primeros meses de vida, como consecuencia de la baja actividad enzimática, la síntesis de AGPI-CL a partir de LA y LNA es reducida, especialmente en los niños con variaciones en los genes que codifican las FADS y ELOVL involucradas en la síntesis de AGPI-CL y que, por tanto, son incapaces de cubrir por sí mismos sus necesidades de ARA y DHA. Los homocigotos para el haplotipo A de las FADS (97 % de la población latinoamericana) muestran niveles de ARA y DHA de tan solo un 43 % y un 24 %, respectivamente, inferiores a los de los individuos con haplotipo D (más frecuente en Europa, África y Asia). La leche humana constituye la única fuente de LA, LNA, ARA y DHA para el recién nacido y el lactante hasta la introducción de la alimentación complementaria (AC). Los niños alimentados con fórmulas infantiles deben recibir las cantidades de LA, LNA, ARA y DHA suficientes para cubrir los requerimientos nutricionales. La nueva normativa de la Autoridad Europea de Seguridad Alimentaria (EFSA) (2016) indica que las fórmulas infantiles de inicio y continuación deben contener entre 20 y 50 mg de DHA/100 kcal (0,5-1 % del total de ácidos grasos: más elevado que en la leche humana y en la mayoría de fórmulas infantiles comercializadas) sin la necesidad de incluir también ARA. Esta nueva regulación, que está vigente desde febrero de 2020, ha despertado una gran controversia, al no existir evidencia científica acerca de su pertinencia y seguridad para los niños sanos. Por ello, diferentes grupos de expertos internacionales han revisado la investigación publicada acerca del ARA y el DHA, y discutido diferentes cuestiones emergentes a partir de esta nueva directiva Europea. El grupo de expertos, liderado desde la Universidad de Granada (España), recomienda la adición de ARA en concentraciones iguales o mayores que las de DHA, alcanzando al menos el contenido presente en la leche humana (0,3 % del total de ácidos grasos), aunque preferiblemente un 0,5 % y hasta alrededor del 0,64 % del total de AG, hasta que nuevos estudios confirmen la ingesta óptima de ARA y DHA durante las distintas etapas del desarrollo. Esta recomendación podría ser de especial importancia para los niños portadores del haplotipo A de las FADS.
- Published
- 2021
60. SARS-CoV-2 RNA and antibody detection in human milk from a prospective multicenter study in Spain
- Author
-
MilkCORONA study team, Elia García Verdevio, Gemma Ruiz-Redondo, Victoria Fumadó, Francesca Crovetto, Marta Selma-Royo, Maria Carmen Collado, Anna Parra-Llorca, Gerardo Rodríguez, Christine Bäuerl, Cecilia Martínez-Costa, Walter Randazzo, Gloria Sánchez, Cristina Campoy, Francisco J. Pérez-Cano, Laura Martínez, Fatima Crispi, Carles Lerin, Fundació La Marató de TV3, Sánchez Moragas, Gloria, Martínez-Costa, Cecilia, Collado, María Carmen, Sánchez Moragas, Gloria [0000-0001-7022-661X], Martínez-Costa, Cecilia [0000-0003-1347-7521], and Collado, María Carmen [0000-0002-6204-4864]
- Subjects
Adult ,2019-20 coronavirus outbreak ,Breast milk ,Coronavirus disease 2019 (COVID-19) ,viruses ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Global health ,global health ,Immunoglobulins ,Antibodies, Viral ,neonatology ,Microbiology ,Coronavirus Envelope Proteins ,Coronavirus Nucleocapsid Proteins ,Humans ,Medicine ,Longitudinal Studies ,Prospective Studies ,skin and connective tissue diseases ,Original Research ,COVID-19, global health, microbiology, neonatology ,Milk, Human ,business.industry ,SARS-CoV-2 ,fungi ,microbiology ,Obstetrics and Gynecology ,RNA ,COVID-19 ,General Medicine ,Phosphoproteins ,Virology ,respiratory tract diseases ,body regions ,Immune system ,Spain ,Llet materna ,Pediatrics, Perinatology and Child Health ,Sistema immunitari ,RNA, Viral ,Female ,Neonatology ,business ,Antibody detection - Abstract
Objectives To develop and validate a specific protocol for SARS-CoV-2 detection in breast milk matrix and to determine the impact of maternal SARS-CoV-2 infection on the presence, concentration and persistence of specific SARS-CoV-2 antibodies. Design and patients This is a prospective, multicentre longitudinal study (April–December 2020) in 60 mothers with SARS-CoV-2 infection and/or who have recovered from COVID-19. A control group of 13 women before the pandemic were also included. Setting Seven health centres from different provinces in Spain. Main outcome measures Presence of SARS-CoV-2 RNA in breast milk, targeting the N1 region of the nucleocapsid gene and the envelope (E) gene; presence and levels of SARS-CoV-2-specific immunoglobulins (Igs)—IgA, IgG and IgM—in breast milk samples from patients with COVID-19. Results All breast milk samples showed negative results for presence of SARS-CoV-2 RNA. We observed high intraindividual and interindividual variability in the antibody response to the receptor-binding domain of the SARS-CoV-2 spike protein for each of the three isotypes IgA, IgM and IgG. Main Protease (MPro) domain antibodies were also detected in milk. 82.9% (58 of 70) of milk samples were positive for at least one of the three antibody isotypes, with 52.9% of these positive for all three Igs. Positivity rate for IgA was relatively stable over time (65.2%–87.5%), whereas it raised continuously for IgG (from 47.8% for the first 10 days to 87.5% from day 41 up to day 206 post-PCR confirmation). Conclusions Our study confirms the safety of breast feeding and highlights the relevance of virus-specific SARS-CoV-2 antibody transfer. This study provides crucial data to support official breastfeeding recommendations based on scientific evidence. Trial registration number NCT04768244., This study has been supported by a research grant from Fundación La Marató-TV3 (MilkCORONA, ref 202106).
- Published
- 2021
61. Unhealthy food advertising. A position paper by the AEP Committee on nutrition and breastfeeding
- Author
-
Juan Rodríguez Delgado, Cristina Campoy, Rafael Galera Martínez, Encina Gallego Mayo, Mercedes Gil-Campos, David González Jiménez, Susana Redecillas Ferreiro, Miguel Sáenz de Pipaón, and Rosaura Leis
- Subjects
Food advertising ,Conducta alimentaria ,Preferencia de alimentos ,Food preference ,Pediatrics, Perinatology and Child Health ,Obesidad ,Eating behavior ,Obesity ,Publicidad de alimentos ,Adolescents ,Niños ,Adolescentes ,Children - Abstract
Introducción: Entre los factores más importantes que influyen en la aparición y el mantenimiento de malos hábitos de alimentación están la accesibilidad y publicidad de los productos alimentarios menos saludables. Con el objetivo de elaborar y fundamentar recomendaciones, se ha realizado un análisis de la evidencia disponible sobre el impacto de la publicidad de alimentos en la salud de niños y adolescentes. Métodos: Se ha realizado una revisión bibliográfica de revisiones sistemáticas y metaanálisis publicados hasta enero del 2022 con el término «food advertising», incluyendo aquellas que analizaban el impacto de la publicidad de alimentos sobre el peso, el índice de masa corporal, la adiposidad, la ingesta dietética, la conducta ante el producto anunciado, su compra o su consumo en niños y adolescentes. Resultados: Fueron incluidas 21 revisiones sistemáticas que incluyen un total de 490 artículos,5 de las cuales contienen además un metaanálisis. La gran mayoría de los estudios primarios evalúan efectos intermedios, relacionados con el comportamiento de niños y adolescentes ante los productos anunciados y su consumo. Existe gran variedad en cuanto al tipo de publicidad y efectos estudiados. La mayoría de los trabajos muestra una asociación entre el tipo de publicidad y el efecto concreto analizado, siendo más evidente en menores de 12 años y en niños obesos. Las revisiones más recientes se centran en la publicidad on-line indicando sus efectos nocivos especialmente en adolescentes. Conclusiones: Los niños y adolescentes constituyen una población especialmente vulnerable. A pesar de la dificultad para demostrar un efecto independiente, hay evidencia de asociación entre la publicidad y los comportamientos en la infancia y adolescencia respecto a los productos anunciados y el aumento de su consumo a corto plazo. En España, los anuncios de productos no saludables siguen muy presentes en los medios y en el entorno on-line de los menores. El Comité de Nutrición y Lactancia Materna de la Asociación Española de Pediatría suscribe la necesidad de una regulación y limitación de la publicidad de alimentos no saludables que abarque todos los medios y todas las estrategias de marketing., Introduction: Some important factors influencing and maintaining unhealthy habits are foodadvertising and products accessibility. In order to develop and support recommendations, ananalysis of the available evidence on the impact of food advertising on the health of childrenand adolescents has been carried out.Methods: Literature review of systematic reviews and meta-analyses published up to January2022 for the term «food advertising» that analyzed the impact of food advertising on weight,body mass index, adiposity, dietary intake, behavior toward the advertised product, its purchaseor consumption in children and adolescents.Results: Twenty-one systematic reviews fulfilled the inclusion criteria, including a total of 490primary studies, 5 of which also contained a meta-analysis. The vast majority of the primarystudies evaluate intermediate effects, related to the behavior of children and adolescents inrelation to advertised products and their consumption. There is great variety in terms of the typeof advertising and effects studied. Most of studies agree that there is an association betweenfood advertising and effect analyzed, being more evident in children under 12 years of age andin obese children. Most recent systematic reviews are focused on on-line advertising, noticingthe negative effects especially in adolescents.Conclusions: Children and adolescents are a particularly vulnerable population to food adverti-sing strategies. Despite the difficulty to demonstrate an independent effect, there is evidenceof an association between food advertising and childhood and adolescents’ behavior respectto the announced products, and the increase of consumption at short-term. In Spain unhealthyproduct advertising are still very common in the media and in the children and adolescent’son-line environment. The Nutrition and Breastfeeding Committee of the Spanish Associationof Pediatrics supports the need for regulation and limitation of unhealthy food advertising,covering all media and marketing strategies.
- Published
- 2022
62. SARS-CoV-2 RNA and antibody detection in human milk from a prospective multicenter study in Spain
- Author
-
Elia Garcia-Verdevio, Francisco J. Pérez-Cano, Gerardo Rodríguez, Maria Carmen Collado, Walter Randazzo, Cecilia Martínez-Costa, Gloria Sánchez, Victoria Fumadó, Francesca Crovetto, Gema Ruíz-Redondo, Fatima Crispi, Carles Lerin, Laura Martínez-Rodríguez, Marta Selma-Royo, Cristina Campoy, Anna Parra-Llorca, Christine Bäuerl, Collado, María Carmen, and Collado, María Carmen [0000-0002-6204-4864]
- Subjects
biology ,business.industry ,Transmission (medicine) ,medicine.medical_treatment ,Breastfeeding ,Disease ,Passive immunity ,Breast milk ,Virus ,Persistence (computer science) ,Immunology ,biology.protein ,Medicine ,Antibody ,business ,skin and connective tissue diseases - Abstract
Background During the COVID-19 pandemic in 2020, breastfeeding in women positive for SARS-CoV-2 was compromised due to contradictory data regarding potential viral transmission. However, growing evidence confirms the relevant role of breast milk in providing passive immunity by generating and transmitting specific antibodies against the virus. Thus, our study aimed to develop and validate a specific protocol to detect SARS-CoV-2 in breast milk matrix as well as to determine the impact of maternal SARS-CoV-2 infection on presence, concentration, and persistence of specific SARS-CoV-2 antibodies. Study design/Methods A prospective multicenter longitudinal study in Spain was carried out from April to December 2020. A total of 60 mothers with SARS-CoV-2 infection and/or recovered from COVID-19 were included (n=52 PCR-diagnosed and n=8 seropositive). Data from maternal-infant clinical records and symptomatology were collected. A specific protocol was validated to detect SARS-CoV-2 RNA in breast milk, targeting the N1 region of the nucleocapsid gene and the envelope (E) gene. Presence and levels of SARS-CoV-2 specific immunoglobulins (Igs) -IgA, IgG, and IgM-in breast milk samples from COVID-19 patients and from 13 women before the pandemic were also evaluated. Results All breast milk samples showed negative results for SARS-CoV-2 RNA presence. We observed high intra- and inter-individual variability in the antibody response to the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein for each of the three isotypes IgA, IgM and IgG. Protease domain (MPro) antibodies were also detected in milk. In general, 82.9 % of the milk samples were positive for at least one of the three antibody isotypes, being 52.86 % of those positive for all three Igs. Positivity rate for IgA was relatively stable over time (65.2 – 87.5 %), whereas it raised continuously for IgG (47.8 % the first ten days to 87.5 % from day 41 up to day 206 post-PCR confirmation). Conclusions Considering the lack of evidence for SARS-CoV-2 transmission through breast milk, our study confirms the safety of breastfeeding practices and highlights the relevance of virus-specific SARS-CoV-2 antibody transfer, that would provide passive immunity to breastfed infants and protect them against COVID-19 disease. This study provides crucial data to support official breastfeeding recommendations based on scientific evidence.
- Published
- 2021
63. Early nutrition in combination with polymorphisms in fatty acid desaturase gene cluster modulate fatty acid composition of cheek cells’ glycerophospholipids in school-age children
- Author
-
Eva Reischl, Cristina Campoy, José Antonio García-Santos, Hans Demmelmair, Hatim Azaryah, Cristina Martínez-Zaldívar, Berthold Koletzko, Signe Altmäe, and Peter Rzehak
- Subjects
Fatty Acid Desaturases ,Male ,0301 basic medicine ,medicine.medical_specialty ,Genotype ,FADS1 ,Offspring ,Linoleic acid ,FADS2 ,Medicine (miscellaneous) ,030209 endocrinology & metabolism ,Glycerophospholipids ,Biology ,Polymorphism, Single Nucleotide ,03 medical and health sciences ,chemistry.chemical_compound ,Delta-5 Fatty Acid Desaturase ,Fish Oils ,0302 clinical medicine ,Pregnancy ,Germany ,Internal medicine ,medicine ,Humans ,Child ,Tetrahydrofolates ,chemistry.chemical_classification ,Arachidonic Acid ,030109 nutrition & dietetics ,Nutrition and Dietetics ,Fatty Acids ,Mouth Mucosa ,Fatty acid ,Prenatal Care ,Cheek ,Endocrinology ,Fatty acid desaturase ,chemistry ,Spain ,Multigene Family ,Dietary Supplements ,biology.protein ,Female ,Docosapentaenoic acid ,Polyunsaturated fatty acid - Abstract
Variants in the human genes of fatty acid (FA) desaturase 1 (FADS1), 2 (FADS2) and 3 (FADS3) are associated with PUFA blood levels. We explored if maternal prenatal supplementation and children’s genetic variation in seventeen SNP of the FADS1, FADS2 and FADS3 gene cluster influence twenty-one of the most relevant cheek cells’ derived FA in glycerophospholipids (GPL-FA). The study was conducted in 147 Spanish and German mother–children pairs participating in the Nutraceuticals for a Healthier Life (NUHEAL) study at 8, 9 and 9·5 years. Linear and mixed model longitudinal regression analyses were performed. Maternal fish-oil (FO) or FO+5-methyltetrahydrofolate (5-MTHF) supplementation during pregnancy was associated with a significant decrease of arachidonic acid (AA) concentrations in cheek cell GPL in the offspring, from 8 to 9·5 years; furthermore, maternal FO+5-MTHF supplementation was associated with higher n-6 docosapentaenoic acid concentrations in their children at age 8 years. FADS1 rs174556 polymorphism and different FADS2 genotypes were associated with higher concentrations of linoleic and α-linolenic acids in children; moreover, some FADS2 genotypes determined lower AA concentrations in children’s cheek cells. It is suggested an interaction between type of prenatal supplementation and the offspring genetic background driving GPL-FA levels at school age. Prenatal FO supplementation, and/or with 5-MTHF, seems to stimulate n-3 and n-6 FA desaturation in the offspring, increasing long-chain PUFA concentrations at school age, but depending on children’s FADS1 and FADS2 genotypes. These findings suggest potential early nutrition programming of FA metabolic pathways, but interacting with children’s FADS polymorphisms.
- Published
- 2019
64. Investigation of the impact of birth by cesarean section on fetal and maternal metabolism
- Author
-
Linda Marchioro, Cristina Campoy, M.T. Segura, Olaf Uhl, Mercedes G. Bermúdez, José Antonio García-Santos, Engy Shokry, and Berthold Koletzko
- Subjects
Adult ,medicine.medical_specialty ,Offspring ,Lipoproteins ,Fatty Acids, Nonesterified ,03 medical and health sciences ,chemistry.chemical_compound ,Fetus ,0302 clinical medicine ,NEFA ,Pregnancy ,Tandem Mass Spectrometry ,Internal medicine ,Humans ,Metabolomics ,Medicine ,Phospholipids ,chemistry.chemical_classification ,030219 obstetrics & reproductive medicine ,Cesarean Section ,Vaginal delivery ,business.industry ,Parturition ,Obstetrics and Gynecology ,Prenatal Care ,General Medicine ,Maternal metabolism ,Tricarboxylic acid ,Delivery, Obstetric ,Fetal Blood ,Endocrinology ,chemistry ,Spain ,030220 oncology & carcinogenesis ,Cord blood ,Female ,Pyruvic acid ,Lipoproteins, HDL ,business ,Chromatography, Liquid - Abstract
Elective cesarean section (CS) was related to long-term adverse health effects in the offspring, but little is known about underlying mechanisms. Our study investigates the metabolic changes in both maternal and cord blood associated with CS in comparison to vaginal delivery (VD) to explore potential causal pathways. Samples obtained from PREOBE study participants were subjected to LC–MS/MS-targeted metabolomics comprising > 200 metabolites. Elective CS showed an impact on both maternal and cord blood metabolomes. In maternal blood, the CS group showed lower levels of phospholipids (PL), principally ether-linked phosphatidylcholines (aaPC), pyruvic acid, branched chain keto-acids (BCKA), and other gluconeogenic substrates, but since the CS group showed different HDL levels in comparison to the VD group, we could not exclude contribution of the latter in the findings. In cord blood, the most remarkable finding in the CS group was the high levels of Cys; conversely, the lower levels of non-esterified fatty acids (NEFA), some tricarboxylic acid (TCA) cycle metabolites, gluconeogenic substrates, markers of β-oxidation, and the sum of hexoses were lower in CS-born babies in addition to tendentially lower levels of PL. We speculate that lower levels of maternal and fetal corticosteroids in CS, due to less stressful condition, cause metabolic perturbations at birth initiating future negative health outcomes. This further supports the early programming hypothesis.
- Published
- 2019
65. Cultural effects on neurodevelopmental testing in children from six European countries: An analysis of NUTRIMENTHE Global Database
- Author
-
Elvira Verduci, Veit Grote, Juan de Dios Luna, Dariusz Gruszfeld, Berthold Koletzko, Henning Tiemeier, Tania Anjos, Miguel Pérez-García, Joaquin Escribano, Pascale Poncelet, Cristina Martínez-Zaldívar, Cristina Campoy, Martina Weber, Jolien Steenweg-de Graaff, Francisco J. Torres-Espínola, Erasmus MC other, and Pediatrics
- Subjects
Male ,050103 clinical psychology ,Databases, Factual ,Culture ,Medicine (miscellaneous) ,Neuropsychological Tests ,Cultural background ,03 medical and health sciences ,0302 clinical medicine ,Mental Processes ,Belgium ,Cultural diversity ,Germany ,Humans ,0501 psychology and cognitive sciences ,Child ,Netherlands ,Nutrition and Dietetics ,05 social sciences ,Confounding ,Neuropsychology ,Gestational age ,Neuropsychological battery ,Italy ,Spain ,Female ,Neuropsychological testing ,Poland ,Psychology ,Child Nutritional Physiological Phenomena ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
Cultural background is an important variable influencing neuropsychological performance. Multinational projects usually involve gathering data from participants from different countries and/or different cultures. Little is known about the influence of culture on neuropsychological testing results in children and especially in European children. The objectives of this study were to compare neuropsychological performance of children from six European countries (Belgium, Germany, Italy, The Netherlands, Poland and Spain) using a comprehensive neuropsychological battery and to apply a statistical procedure to reduce the influence of country/cultural differences in neuropsychological performance. As expected, the results demonstrated differences in neuropsychological performance among children of the six countries involved. Cultural differences remained after adjusting for other confounders related to neuropsychological execution, such as sex, type of delivery, maternal age, gestational age and maternal educational level. Differences between countries disappeared and influence of culture was considerably reduced when standardised scores by country and sex were used. These results highlight the need for developing specific procedures to compare neuropsychological performance among children from different cultures to be used in multicentre studies.
- Published
- 2019
66. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Amino acids
- Author
-
Johannes B. van Goudoever, Virgilio Carnielli, Dominique Darmaun, Miguel Sainz de Pipaon, Christian Braegger, Jiri Bronsky, Wei Cai, Cristina Campoy, Tamás Decsi, Magnus Domellöf, Nicholas Embleton, Mary Fewtrell, Nataša Fidler Mis, Axel Franz, Olivier Goulet, Corina Hartman, Susan Hill, Iva Hojsak, Silvia Iacobelli, Frank Jochum, Koen Joosten, Sanja Kolaček, Berthold Koletzko, Janusz Ksiazyk, Alexandre Lapillonne, Szimonetta Lohner, Dieter Mesotten, Krisztina Mihályi, Walter A. Mihatsch, Francis Mimouni, Christian Mølgaard, Sissel J. Moltu, Antonia Nomayo, Jean Charles Picaud, Christine Prell, John Puntis, Arieh Riskin, Miguel Saenz De Pipaon, Thibault Senterre, Raanan Shamir, Venetia Simchowitz, Peter Szitanyi, Merit M. Tabbers, Chris H.B. Van Den Akker, Johannes B. Van Goudoever, Anne Van Kempen, Sascha Verbruggen, Jiang Wu, Weihui Yan, University of Amsterdam [Amsterdam] (UvA), Salesi Hospital, Partenaires INRAE, Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes (UN)-Institut National de la Recherche Agronomique (INRA), Universidad Autonoma de Madrid (UAM), Neonatology, ARD - Amsterdam Reproduction and Development, AGEM - Digestive immunity, Paediatric Gastroenterology, AGEM - Re-generation and cancer of the digestive system, ACS - Diabetes & metabolism, AGEM - Endocrinology, metabolism and nutrition, Amsterdam Reproduction & Development (AR&D), Pediatrics, and Pediatric surgery
- Subjects
0301 basic medicine ,Parenteral Nutrition ,medicine.medical_specialty ,Critical Care and Intensive Care Medicine ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,medicine ,Humans ,Amino Acids ,requirements ,Child ,Intensive care medicine ,ComputingMilieux_MISCELLANEOUS ,2. Zero hunger ,chemistry.chemical_classification ,030109 nutrition & dietetics ,Nutrition and Dietetics ,business.industry ,pediatric parenteral nutrition ,Infant, Newborn ,toxicity ,Infant ,deficiency ,3. Good health ,Amino acid ,Parenteral nutrition ,chemistry ,Child, Preschool ,Child Nutritional Physiological Phenomena ,business ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,Infant, Premature - Abstract
International audience
- Published
- 2018
67. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Venous access
- Author
-
Nicholas D. Embleton, Merit M. Tabbers, Thibault Senterre, Sissel J. Moltu, Christine Prell, Jean Charles Picaud, Olivier Goulet, Peter Szitanyi, Christian Mølgaard, Christian Braegger, Nataša Fidler Mis, Lohner Szimonetta, Anne A.M.W. van Kempen, Dieter Mesotten, Corina Hartman, Chris H. B. van den Akker, Sascha Verbruggen, Jiri Bronsky, Raanan Shamir, Arieh Riskin, Decsi Tamas, Iva Hojsak, I. Hojsak, Francis B. Mimouni, Wu Jiang, Antonia Nomayo, Magnus Domellöf, Koen F. M. Joosten, Walter A. Mihatsch, Mihalyi Krisztina, Janusz Ksiazyk, Miguel Saenz de Pipaon, Virgilio P. Carnielli, Axel R. Franz, Cristina Campoy, Mary Fewtrell, Cai Wei, Yan Weihui, Frank Jochum, Susan Hill, Sanja Kolaček, Venetia Simchowitz, Silvia Iacobelli, Berthold Koletzko, Johannes B. van Goudoever, John W. L. Puntis, Dominique Darmaun, John W L Puntis, Alexandre Lapillonne, Pediatric surgery, Pediatrics, ACS - Diabetes & metabolism, AGEM - Endocrinology, metabolism and nutrition, Amsterdam Reproduction & Development (AR&D), University of Zagreb, The General Infirmary at Leeds, Children's Hospital Zagreb, Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes (UN)-Institut National de la Recherche Agronomique (INRA), ARD - Amsterdam Reproduction and Development, AGEM - Digestive immunity, Paediatric Gastroenterology, AGEM - Re-generation and cancer of the digestive system, and Neonatology
- Subjects
Catheterization, Central Venous ,Parenteral Nutrition ,medicine.medical_specialty ,Central catheter ,Topical treatment ,Critical Care and Intensive Care Medicine ,central venous catheters ,central line ,central catheter ,central venous access ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,medicine ,Central Venous Catheters ,Humans ,Skin hygiene ,030212 general & internal medicine ,Child ,Intensive care medicine ,ComputingMilieux_MISCELLANEOUS ,Nutrition and Dietetics ,business.industry ,Infant, Newborn ,Catheter blockage ,Infant ,Pediatric parenteral nutrition ,Catheter-Related Infections ,3. Good health ,Venous access ,Parenteral nutrition ,Child, Preschool ,Intravenous nutrition ,Child Nutritional Physiological Phenomena ,business ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition ,Infant, Premature ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Venous access
- Published
- 2018
68. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Iron and trace minerals
- Author
-
M. Domellöf, P. Szitanyi, V. Simchowitz, A. Franz, F. Mimouni, Christian Braegger, Jiri Bronsky, Wei Cai, Cristina Campoy, Virgilio Carnielli, Dominique Darmaun, Tamás Decsi, Magnus Domellöf, Nicholas Embleton, Mary Fewtrell, Nataša Fidler Mis, Axel Franz, Olivier Goulet, Corina Hartman, Susan Hill, Iva Hojsak, Silvia Iacobelli, Frank Jochum, Koen Joosten, Sanja Kolaček, Berthold Koletzko, Janusz Ksiazyk, Alexandre Lapillonne, Szimonetta Lohner, Dieter Mesotten, Krisztina Mihályi, Walter A. Mihatsch, Francis Mimouni, Christian Mølgaard, Sissel J. Moltu, Antonia Nomayo, Jean Charles Picaud, Christine Prell, John Puntis, Arieh Riskin, Miguel Saenz De Pipaon, Thibault Senterre, Raanan Shamir, Venetia Simchowitz, Peter Szitanyi, Merit M. Tabbers, Chris H.B. Van Den Akker, Johannes B. Van Goudoever, Anne Van Kempen, Sascha Verbruggen, Jiang Wu, Weihui Yan, Umeå University, Charles University in Prague, Partenaires INRAE, Great Ormond Street Hospital for Children NHS Foundation Trust, University Children's Hospital of Tübingen, Tel Aviv University [Tel Aviv], Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes (UN)-Institut National de la Recherche Agronomique (INRA), Pediatrics, Pediatric surgery, ACS - Diabetes & metabolism, AGEM - Endocrinology, metabolism and nutrition, Amsterdam Reproduction & Development (AR&D), ARD - Amsterdam Reproduction and Development, AGEM - Digestive immunity, Paediatric Gastroenterology, AGEM - Re-generation and cancer of the digestive system, and Neonatology
- Subjects
0301 basic medicine ,Parenteral Nutrition ,medicine.medical_specialty ,Iron ,iron ,trace minerals ,Critical Care and Intensive Care Medicine ,03 medical and health sciences ,0302 clinical medicine ,Metals, Heavy ,medicine ,Humans ,Child ,Intensive care medicine ,ComputingMilieux_MISCELLANEOUS ,2. Zero hunger ,030109 nutrition & dietetics ,Nutrition and Dietetics ,business.industry ,Infant, Newborn ,Infant ,Iron and trace minerals ,Pediatric parenteral nutrition ,Iron Deficiencies ,Iron deficiency ,medicine.disease ,Trace Elements ,3. Good health ,Parenteral nutrition ,Trace Minerals ,Child, Preschool ,030211 gastroenterology & hepatology ,Child Nutritional Physiological Phenomena ,Deficiency Diseases ,business ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition ,Infant, Premature ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition : Iron and trace minerals
- Published
- 2018
69. Role of Incentives in Long-term Nutritional and Growth Studies in Children
- Author
-
Berthold Koletzko, Mary Fewtrell, Cristina Campoy, Kathy Kennedy, and Nataša Fidler Mis
- Subjects
medicine.medical_specialty ,Biomedical Research ,Adolescent ,Research Subjects ,media_common.quotation_subject ,MEDLINE ,Child Nutrition Sciences ,Compliance (psychology) ,03 medical and health sciences ,0302 clinical medicine ,Research Support as Topic ,030225 pediatrics ,Humans ,Medicine ,Child ,Reimbursement, Incentive ,Reimbursement ,media_common ,Motivation ,biology ,business.industry ,Patient Selection ,Infant, Newborn ,Gastroenterology ,Infant ,Euros ,biology.organism_classification ,Voucher ,Incentive ,Child, Preschool ,Family medicine ,Cash ,Pediatrics, Perinatology and Child Health ,030211 gastroenterology & hepatology ,business ,Developed country - Abstract
Objectives: Available published advice on use of incentives is limited and generally refers to short-term studies without longer follow-up, predominantly conducted in developed countries. We aim to summarize published information related to the use of incentives in long-term nutrition studies involving infants, children, and adolescents and the views of researchers in the field, to provide guidance on acceptable incentives. We conducted a literature review and a short online survey of researchers regarding their opinions on the use of incentives in paediatric long-term (follow-up) clinical studies. Responses from 38 researchers from 14 different countries indicated that 41% had used incentives to increase participation and 29% to 73%, depending on child's age and type of procedure, thought incentives may be used to increase compliance with follow-up visits. A small number of respondents thought incentives would not be approved by national ethics boards. Based on the literature review and the survey results, and European Society for Paediatric Gastroenterology, Hepatology and Nutrition working group concluded that incentives for children and adolescents up to the value of 30 Euros, based on average EU income levels, may be offered as cash, vouchers, or age-appropriate gifts or toys, in addition to reimbursing expenses. Additional incentives may be offered if a study includes more burdening procedures, techniques that may appear frightening for younger children, or requires sustained participation (eg, dietary diaries or activity monitoring). There was agreement that it is preferable to give toys or gifts rather than money to younger children.
- Published
- 2018
70. Rapid and simultaneous determination of histidine metabolism intermediates in human and mouse microbiota and biomatrices
- Author
-
Alicia Ruiz, Samuel Cantarero, Cristina Campoy, Margarita Aguilera, Ana López-Moreno, Inmaculada Acuña, Tomás Cerdó, Antonio Suárez, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), University of Granada (España), and Ministerio de Educación, Cultura y Deporte (España)
- Subjects
Electrospray ionization ,Clinical Biochemistry ,Cell ,Microbial metabolism ,Urine ,Tandem mass spectrometry ,Biochemistry ,chemistry.chemical_compound ,Feces ,Mice ,Tandem Mass Spectrometry ,Histidine pathway ,medicine ,Animals ,Humans ,Histidine ,Chromatography, High Pressure Liquid ,Chemistry ,Microbiota ,General Medicine ,Gastrointestinal Microbiome ,medicine.anatomical_structure ,Diabetes Mellitus, Type 2 ,Molecular Medicine ,Histamine ,UHPLC-ESI-MS/MS - Abstract
European Food Safety Authority; FEDER-Infraestructure Consejeria de Economia, Conocimiento, Empresas y Universidad, Grant/Award Number: IE_2019-198, Histidine metabolism is a key pathway physiologically involved in satiety, recognition memory, skin, and neural protection and allergic diseases. Microbiologicallyproduced imidazole propionate induces type II diabetes and interferes with glucose lowering drugs. Despite their determinant health implications, no single method simultaneously assesses histidine metabolites in urine, feces, and microbiota. The aim of this study was to develop a simple, rapid, and sensitive method for the determination of histidine and its major bioactive metabolites histamine, N-acetylhistamine, imidazole-4-acetate, cis-urocanate, trans-urocanate, glutamate and imidazole propionate, using ultrahigh-performance liquid chromatography with electrospray ionization tandem mass spectrometry. An innovative simple extraction method from small aliquots of human and mice urine, feces and microbial cell extracts was coupled to separation in a 6.5 min chromatographic run. The successful performance allowed accurate and precise quantification of all metabolites in mouse feces, suggesting broad exchange of histidine metabolites between the gut and mice. Higher urine histamine, histamine to histidine ratio, and imidazole-4-acetate pointed to an underlying inflammatory or allergic process in mice compared to human subjects. N-acetylhistamine and imidazole propionate were detected in human and mouse feces, confirming its origin from gut microbial metabolism. Our novel and robust analytical method captured histidine metabolism in a single assay that will facilitate broad and deep histidine metabolic phenotyping assessing the impact of microbiota on host health in large-scale human observational and interventional studies., European Food Safety Authority, FEDER-Infraestructure Consejeria de Economia, Conocimiento, Empresas y Universidad IE_2019-198
- Published
- 2021
71. Growth patterns and breast milk/infant formula energetic efficiency in healthy infants up to 18 months of life: the COGNIS study
- Author
-
María Teresa Miranda, Mireia Escudero-Marín, Estefanía Diéguez, Natalia Sepúlveda-Valbuena, Cristina Campoy, María Rodríguez-Palmero, Mercedes G. Bermúdez, José Antonio García-Santos, Roser De-Castellar, Ana Nieto-Ruiz, and Florian Herrmann
- Subjects
Breast milk ,Bioactive nutrients ,Medicine (miscellaneous) ,Who standards ,Growth velocity ,Animal science ,Standard infant formula ,Medicine ,Humans ,Nutrition and Dietetics ,Milk protein ,Milk, Human ,business.industry ,Infant ,Growth patterns ,Nutrients ,Infant Formula ,Energetic efficiency ,Head circumference ,Breast Feeding ,Infant formula ,Female ,business ,Formula fed - Abstract
This project has been funded by Laboratorios Ordesa, S. L. Contract University of Granada General Foundation, No. 3349 and SMARTFOODS (CIEN) Contract University of Granada General Foundation, No. 4003, Spanish Ministry of Economy, Industry and Competitiveness, and partially funded by HORIZON 2020 EU DynaHEALTH Project (GA No.633595). N. S-V. has been granted with a scholarship from Fundaci ' on Carolina, Madrid, Spain., Type of feeding during early life influences growth trajectory and metabolic risk at later ages. Modifications in infant formula composition have led to evaluate their effects on growth and energetic efficiency (EE) compared with breast-feeding. Main goal was to analyse type of feeding potential effects during first months of life, plus its EE, on growth patterns in healthy formula fed (standard infant formula (SF) vs. experimental infant formula enriched with bioactive nutrients (EF)) and breastfed (BF) infants participating in the COGNIS RCT (http://www.ClinicalTrials.gov, Identifier: NCT02094547) up to 18 months of age. Infants follow-up to 18 months of age (n 141) fed with a SF (n 48), EF(n 56), or BF (n 37), were assessed for growth parameters using WHO standards. Growth velocity (GV) and catch-up were calculated to identify growth patterns. EE of breast milk/infant formula was also estimated. Infants' growth at 6 months showed higher length and lower head circumference gains in SF and EF infants than BF infants. Both weight-for-length and weight-for-age catch-up growth showed significant differences in formula fed groups compared with the BF. No significant differences in GV or catch-up were found at 6-12 and 12-18 months. Regarding EE, infant formula groups showed significantly lower weight and length gains/g of milk protein, and higher weight and length gains/g of milk lipids, than the BF infants. GV during first 6 months, which may be influenced by feeding, seems to be the main predictor of subsequent growth trajectory. Breast-feeding may have positive effects on growth programming due to its nutrients' EE., Laboratorios Ordesa, S. L. Contract University of Granada General Foundation 3349, SMARTFOODS (CIEN) Contract University of Granada General Foundation 4003, Spanish Ministry of Economy, Industry and Competitiveness, HORIZON 2020 EU DynaHEALTH Project 633595, Fundacion Carolina, Madrid, Spain
- Published
- 2021
72. Long-Term Safety and Efficacy of Prebiotic Enriched Infant Formula—A Randomized Controlled Trial
- Author
-
V. Varea, José Antonio Moreno-Muñoz, Jesús Palencia, Joaquin Alonso, Francisco Guarner, Stephan Theis, Franka Neumer, Gigi Veereman, María Rodríguez-Palmero, Orenci Urraca, Cristina Campoy, Yvan Vandenplas, Institut Català de la Salut, [Neumer F] BENEO-Institute, c/o BENEO GmbH, 67283 Obrigheim, Germany. [Urraca O] Hospital de Nens, 08009 Barcelona, Spain. [Alonso J] CAP Llefià, 08913 Badalona, Spain. [Palencia J] Equipo Pediátrico San Francisco, 28036 Madrid, Spain. [Varea V] Department of Gastroenterology, Hospital Sant Joan de Déu, 08017 Barcelona, Spain. [Guarner F] Unitat de Recerca en l’Aparell Digestiu, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, Clinical sciences, Growth and Development, and Pediatrics
- Subjects
0301 basic medicine ,Male ,Time Factors ,medicine.medical_treatment ,oligofructose ,efficacy ,Prebiotic ,Gut flora ,Gastroenterology ,law.invention ,Feces ,0302 clinical medicine ,Randomized controlled trial ,law ,Prospective Studies ,Bifidobacterium ,education.field_of_study ,Nutrition and Dietetics ,biology ,inulin ,Crying ,Incidence ,Inulin ,infant formula ,Intention to Treat Analysis ,Treatment Outcome ,prebiotic ,Carbohydrates::Dietary Carbohydrates::Dietary Fiber::Prebiotics [CHEMICALS AND DRUGS] ,Infant formula ,Other subheadings::Other subheadings::/administration & dosage [Other subheadings] ,030211 gastroenterology & hepatology ,Female ,medicine.symptom ,Safety ,hidratos de carbono::carbohidratos de la dieta::fibras de la dieta::prebióticos [COMPUESTOS QUÍMICOS Y DROGAS] ,Infection ,lcsh:Nutrition. Foods and food supply ,Llet maternitzada ,safety ,medicine.medical_specialty ,Prebiòtics ,Efficacy ,Population ,Oligofructose ,lcsh:TX341-641 ,Infections ,Article ,03 medical and health sciences ,Double-Blind Method ,Internal medicine ,medicine ,Humans ,Physiological Phenomena::Diet, Food, and Nutrition::Beverages::Milk Substitutes::Infant Formula [PHENOMENA AND PROCESSES] ,Pediatrics, Perinatology, and Child Health ,education ,Otros calificadores::Otros calificadores::/administración & dosificación [Otros calificadores] ,030109 nutrition & dietetics ,Intention-to-treat analysis ,business.industry ,fenómenos fisiológicos::dieta, alimentación y nutrición::bebidas::sustitutivos de la leche::fórmulas infantiles [FENÓMENOS Y PROCESOS] ,Infant, Newborn ,Infant ,diagnóstico::pronóstico::resultado del tratamiento [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,biology.organism_classification ,Diagnosis::Prognosis::Treatment Outcome [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,infection ,Bottle Feeding ,Gastrointestinal Microbiome ,Prebiotics ,Avaluació de resultats (Assistència sanitària) ,business ,Biomarkers ,Food Science - Abstract
The clinical study was part of the EARNEST project (EARly Nutrition programminglong term follow up of Efficacy and Safety Trials and integrated epidemiological, genetic, animal, consumer and economic research), an EU-funded integrated project within the 6th Framework Programme (FOOD-CT-2005-007036). Within this project, Laboratorios Ordesa, Barcelona, Spain and BENEO-Orafti, Tienen, Belgium contributed to the overall funding of the SYNERGY-1 study., The following are available online at https://www.mdpi.com/article/10 .3390/nu13041276/s1, Table S1: Study formula characteristics, Table S2: Primer selection for qPCR, Table S3: Growth-related variables of infants following the consumption of either prebiotic vs. control formula at the following time points: age of 2, 4, 6, 9 and 12 months, Table S4: Amount of formula ingested following the consumption of either prebiotic vs. control formula at the following time points: age of 2, 4, 6, 9 and 12 months, Table S5: Number of infections until 12 months of age, Table S6: Digestive symptoms of the infants by feeding group and study time., The study was performed following the Helsinki declaration and the guidelines for the ethical conduct of medical research involving children. The study protocol was approved by the Ethical Committees of all participating hospitals and the CEIC Fundacio Sant Joan de Déu (Central Ethical Committee Spain, approval No: 2008)., Written informed consent was obtained from the parents or guardians of the infants, This study was financed in part by the Commission of the European Communities, within FP6 (contract 007036), as it was part of the Early Nutrition Programming [EARNEST] project., The present study aims to evaluate the effects of an infant formula supplemented with a mixture of prebiotic short and long chain inulin-type oligosaccharides on health outcomes, safety and tolerance, as well as on fecal microbiota composition during the first year of life. In a prospective, multicenter, randomized, double-blind study, n = 160 healthy term infants under 4 months of age were randomized to receive either an infant formula enriched with 0.8 g/dL of Orafti(R)Synergy1 or an unsupplemented control formula until the age of 12 months. Growth, fever (>38 degrees C) and infections were regularly followed up by a pediatrician. Digestive symptoms, stool consistency as well as crying and sleeping patterns were recorded during one week each study month. Fecal microbiota and immunological biomarkers were determined from a subgroup of infants after 2, 6 and 12 months of life. The intention to treat (ITT) population consisted of n = 149 infants. Both formulae were well tolerated. Mean duration of infections was significantly lower in the prebiotic fed infants (p < 0.05). The prebiotic group showed higher Bifidobacterium counts at month 6 (p = 0.006), and higher proportions of Bifidobacterium in relation to total bacteria at month 2 and 6 (p = 0.042 and p = 0.013, respectively). Stools of infants receiving the prebiotic formula were softer (p < 0.05). Orafti(R)Synergy1 tended to beneficially impact total daily amount of crying (p = 0.0594). Supplementation with inulin-type prebiotic oligosaccharides during the first year of life beneficially modulates the infant gut microbiota towards higher Bifidobacterium levels at the first 6 months of life, and is associated with reduced duration of infections., European Commission FOOD-CT-2005-007036
- Published
- 2021
- Full Text
- View/download PDF
73. Perinatal nutritional intervention
- Author
-
Tomás Cerdó, Estefanía Diéguez, Cristina Campoy, and Mireia Escudero-Marín
- Subjects
medicine.medical_specialty ,biology ,business.industry ,Disease ,Gut flora ,biology.organism_classification ,Intervention studies ,Functional development ,Intervention (counseling) ,Coming out ,Medicine ,Observational study ,Epigenetics ,business ,Intensive care medicine - Abstract
Fetal and infancy periods are critical for growth and organ functional development; some factors during early life are able to produce harmful effects with long-term and even intergenerational consequences. Observational studies performed in humans and experimental studies in animal models have provided evidences about how alterations in the early nutritional environment will produce epigenetic disturbances involved in energy expenditure regulation, immune system, and other systemic effects, promoting the development of certain diseases. Nonetheless, there are few intervention studies carried out in humans, analyzing epigenetic changes and their role on disease development. Furthermore, in previous research the role of gut microbiota throughout signaling of its metabolites on the developmental patterns of immune system related-diseases and noncommunicable diseases has been less studied. Here, we update the knowledge available from the perinatal nutritional intervention studies performed. The results coming out from these studies are generating new opportunities for future early personalized prevention and therapeutical strategies.
- Published
- 2021
74. Effect of increased physical activity on physical fitness in an overweight and/or obese group of adolescents
- Author
-
Manuel Delgado-Fernández, Miguel Martín-Matillas, Isabel María Ruiz López, Cristina Campoy Folgoso, Antonio Verdejo-García, and Elena Delgado-Rico
- Subjects
Complementary and Manual Therapy ,medicine.medical_specialty ,Physical fitness ,Obesidad ,Physical Therapy, Sports Therapy and Rehabilitation ,Overweight ,Adolescents ,World health ,Education ,Lower body ,Occupational Therapy ,medicine ,7 Bellas artes::79 - Diversiones. Espectáculos. Cine. Teatro. Danza. Juegos.Deportes [CDU] ,Orthopedics and Sports Medicine ,Obesity ,Condición Física ,Adolescentes ,Condición física ,Physical activity ,business.industry ,Upper body ,Cardiorespiratory fitness ,medicine.disease ,Test (assessment) ,Actividad Física ,Sobrepeso ,GV557-1198.995 ,Physical therapy ,medicine.symptom ,business ,Sports - Abstract
Se analiza el efecto del incremento de actividad física (AF) para conseguir el cumplimiento de recomendaciones de AF para la mejora de la salud según la Organización Mundial de la Salud en un grupo de 42 adolescentes (28 chicas) con sobrepeso/obesidad (IMC=29.37±4.5 Kg/m²). El tratamiento de 12 semanas de duración consistió en la prescripción y seguimiento de AF en dos fases: intensiva (seguimiento semanal) y extensiva (seguimiento quincenal). El nivel de AF se valoró mediante el cuestionario Physician-based Assessment and Counseling y la condición física median-te pruebas de fuerza isométrica del tren superior, fuerza explosiva de piernas y capacidad cardiorrespiratoria de la batería ALPHA. Tras el tratamiento se observa una mejora significativa (p
- Published
- 2021
75. The Effects of an Infant Formula Enriched with Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids and Synbiotics on Child Behavior up to 2.5 Years Old: The COGNIS Study
- Author
-
Cristina Campoy, Natalia Sepúlveda-Valbuena, Jesús Jiménez, Andrés Catena, Estefanía Diéguez, Mercedes G. Bermúdez, José Antonio García-Santos, María Teresa Miranda, Miguel Pérez-García, Tomás Cerdó, Roser De-Castellar, Florian Herrmann, Ana Nieto-Ruiz, Francisca López-Torrecillas, [Nieto-Ruiz,A, Diéguez,E, Sepúlveda-Valbuena,N, Herrmann,F, Cerdó,T, García-Santos,JA, Bermúdez,MG, Campoy,C] Department of Paediatrics, School of Medicine, University of Granada, Granada, Spain. [Nieto-Ruiz,A, Campoy,C] EURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, University of Granada, Granada, Spain. [Nieto-Ruiz,A, Campoy,C] Instituto de Investigación Biosanitaria ibs. GRANADA, Health Sciences Technological Park, Granada, Spain. [Nieto-Ruiz,A, López-Torrecillas,F, Pérez-García,M, Catena,A] Mind, Brain and Behaviour Research Centre-CIMCYC, University of Granada, Granada, Spain. [Sepúlveda-Valbuena,N] Nutrition and Biochemistry Department, Faculty of Sciences, Pontificia Universidad Javeriana, Bogotá, Colombia. [López-Torrecillas,F] Department of Personality, Evaluation and Psychological Treatment, School of Psychology, University of Granada, Granada, Spain. [De-Castellar,R, Jiménez,J] Ordesa Laboratories, S.L., Barcelona, Spain. [Miranda,MT] Department of Biostatistics, School of Medicine, University of Granada, Granada, Spain. [Campoy,C] Spanish Network of Biomedical Research in Epidemiology and Public Health (CIBERESP), Granada’s Node, Institute of Health Carlos III, Madrid, Spain., This project has been funded by Ordesa Laboratories, S.L. Contract University of Granada General Foundation, No. 3349 and SMARTFOODS (CIEN) Contract University of Granada General Foundation, No. 4003, Spanish Ministry of Economy, Industry and Competitiveness, and and partially funded by HORIZON 2020 EU DynaHEALTH Project (GA No. 633595). Natalia Sepúlveda-Valbuena has been granted with a scholarship from Fundación Carolina, Madrid, Spain. Publication expenses for this article has been supported by Cátedra ORDESA-University of Granada, Spain as part of Special Issue 'Early Nutrition and Re-programming of Health and Disease'.
- Subjects
Male ,Pediatrics ,breastfeeding ,Psychiatry and Psychology::Mental Disorders [Medical Subject Headings] ,Breastfeeding ,Child Behavior ,Synbiotics ,Chemicals and Drugs::Carbohydrates::Glycoconjugates::Glycoproteins [Medical Subject Headings] ,Fórmulas infantiles ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] ,0302 clinical medicine ,Child Development ,Standard infant formula ,Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Child Nutritional Physiological Phenomena::Infant Nutritional Physiological Phenomena::Breast Feeding [Medical Subject Headings] ,Prospective Studies ,Child Behavior Checklist ,Infant Nutritional Physiological Phenomena ,2. Zero hunger ,chemistry.chemical_classification ,Persons::Persons::Age Groups::Infant [Medical Subject Headings] ,Nutrition and Dietetics ,Lactancia materna ,infant formula ,Brain development ,Technology and Food and Beverages::Food and Beverages::Food::Foods, Specialized::Food, Fortified [Medical Subject Headings] ,3. Good health ,Breast Feeding ,Child, Preschool ,Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Child Behavior [Medical Subject Headings] ,Chemicals and Drugs::Lipids::Glycolipids [Medical Subject Headings] ,Food, Fortified ,Fatty Acids, Unsaturated ,Anxiety ,Female ,medicine.symptom ,lcsh:Nutrition. Foods and food supply ,Polyunsaturated fatty acid ,milk fat globule membrane ,medicine.medical_specialty ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies [Medical Subject Headings] ,Offspring ,Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Child Nutritional Physiological Phenomena::Infant Nutritional Physiological Phenomena [Medical Subject Headings] ,Technology and Food and Beverages::Food and Beverages::Food::Dietary Supplements::Synbiotics [Medical Subject Headings] ,Technology and Food and Beverages::Food and Beverages::Beverages::Milk::Infant Formula [Medical Subject Headings] ,Check Tags::Male [Medical Subject Headings] ,Long chain polyunsaturated fatty acids ,lcsh:TX341-641 ,children behavior ,Article ,long-chain polyunsaturated fatty acids ,03 medical and health sciences ,Ácidos grasos insaturados ,Double-Blind Method ,030225 pediatrics ,Trastornos del neurodesarrollo ,medicine ,Humans ,Glycoproteins ,bioactive compounds ,Conducta infantil ,business.industry ,Infant, Newborn ,Infant ,Lipid Droplets ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Methods::Research Design::Double-Blind Method [Medical Subject Headings] ,Mental health ,Persons::Persons::Age Groups::Infant::Infant, Newborn [Medical Subject Headings] ,Psychiatry and Psychology::Behavior and Behavior Mechanisms::Human Development::Child Development [Medical Subject Headings] ,Check Tags::Female [Medical Subject Headings] ,Infant formula ,chemistry ,Neurodevelopmental Disorders ,Glycolipids ,business ,Persons::Persons::Age Groups::Child::Child, Preschool [Medical Subject Headings] ,Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids, Unsaturated [Medical Subject Headings] ,030217 neurology & neurosurgery ,Food Science - Abstract
Although early life nutrition influences brain development and mental health, the long-term e ects of supplemented infant formula on children´s behavior remain unclear. We analyzed the e ects of a bioactive nutrients-enriched-infant formula on children’s behavior up to 2.5 years, compared to a standard infant formula or breastfeeding. Current analysis involved 70 children who were fed a standard infant formula (SF, n = 29) or a bioactive compounds enriched-infant formula (EF, n = 41), during their first 18 months of life, and 33 breastfed (BF) children (reference group) participating in the COGNIS study. Behavioral problems were evaluated using the Child Behavior Checklist at 18 months and 2.5 years. Di erent statistical analyses were performed using SPSS. EF children aged 2.5 years presented fewer pathological a ective problems than SF children. Besides, SF children were classified more frequently as bordering on internalizing problems than BF children. Rates of externalizing problems were increased in SF infants compared to EF and BF infants. Higher maternal IQ was found to have beneficial e ects on internalizing and total problem rate in their o spring at 18 months of life; finally, higher maternal educational level was related with fewer ADHD problems in children at 18 months, as well as internalizing, externalizing, total and anxiety problems in children aged 2.5 years. Our analysis suggests that enriched infant formula fed infants seem to show fewer behavioral problems up to 2.5 years compared to a standard infant formula-fed infants. In addition to type of early feeding, maternal IQ and educational level seem to play a key role on children behavioral development., Ordesa Laboratories, S.L. Contract University of Granada General Foundation 3349, SMARTFOODS (CIEN) Contract University of Granada General Foundation 4003, Spanish Ministry of Economy, Industry and Competitiveness, HORIZON 2020 EU DynaHEALTH Project 633595, Fundación Carolina, Madrid, Spain, Catedra ORDESA-University of Granada, Spain as part of Special Issue "Early Nutrition and Re-programming of Health and Disease"
- Published
- 2020
76. Association study of rs1801282 PPARG gene polymorphism and immune cells and cytokine levels in a Spanish pregnant women cohort and their offspring
- Author
-
Mercedes García-Bermúdez, M. Teresa Segura Moreno, María García-Ricobaraza, Cristina Campoy, Ascensión Marcos, Mathieu Nahounou Bleyere, Francisco J. Torres-Espínola, Esther Nova, Ligia E. Díaz-Prieto, Junta de Andalucía, Ministerio de Economía y Competitividad (España), and Abbott Laboratories
- Subjects
Adult ,0301 basic medicine ,medicine.medical_specialty ,Peroxisome proliferator-activated receptor gamma ,Offspring ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Clinical Biochemistry ,lcsh:Medicine ,Polymorphism, Single Nucleotide ,Newborn cord blood ,Cohort Studies ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Pro12Ala PPARG polymorphism ,Pregnancy ,Polymorphism (computer science) ,Internal medicine ,Genotype ,medicine ,Humans ,Pharmacology (medical) ,Molecular Biology ,Innate immune system ,business.industry ,Research ,lcsh:R ,Pregnant mothers ,Biochemistry (medical) ,Cell Biology ,General Medicine ,Immunity, Innate ,PPAR gamma ,030104 developmental biology ,Cytokine ,Endocrinology ,030220 oncology & carcinogenesis ,Cord blood ,Cytokines ,Female ,business - Abstract
[Background]: Peroxisome proliferator activated receptor gamma (PPARG) belongs to the nuclear receptor superfamily functioning as transcription factors to regulate cellular differentiation, development and metabolism. Moreover, it has been implicated in the regulation of lipid metabolism, as well as the maturation of monocytes/macrophages and the control of inflammatory reactions. The aim of this study was to evaluate the relationship between the Pro12Ala (rs1808212) PPARG gene polymorphism on immune molecular and cellular components in mothers and their offspring participating in the PREOBE study., [Methods]: DNA from maternal venous blood samples at 24, 34 and 40 gestational weeks, plus cord blood samples was extracted. Pro12Ala PPARG polymorphism genotyping was performed, and immune system markers were analyzed by flow cytometry., [Results]: Study findings revealed no effect of rs1808212 PPARG genotypes on innate immune parameters in mothers and their offspring; however, CD4 + /CD8 + ratio were decreased at 24 and 34 weeks in pregnant women carrying the CG (Pro12Ala) rs1808212 polymorphism, (p = 0,012 and p = 0,030; respectively). Only CD19 levels in peripheral blood were significantly higher at delivery in pregnant women carrying the CC (Pro12Pro) genotype (p ≤ 0.001). Moreover, there were statistically significant differences in leukocytes and neutrophils maternal levels at 34 weeks of gestation, being lower in carriers of Pro12Ala genotype (p = 0.028 and p = 0.031, respectively)., [Conclusions]: Results suggest that Pro12Ala PPARG polymorphism may have an effect on some cell and immune parameters in pregnant women during pregnancy and at time of delivery. However, newborn innate immune system does not seems to be influenced by PPARG Pro12Ala polymorphism in cord blood., This study was funded by Andalusian Ministry of Innovation and Science, Junta de Andalucía, Excellence Project [P06-CTS-02341]; Spanish Ministry of Economy and Competitiveness [BFU2012-40254-C03-01]. Further support was received by Abbott Laboratories, Granada, Spain.
- Published
- 2020
77. The Nutritional Profile of Food Advertising for School-Aged Children via Television: A Longitudinal Approach
- Author
-
Hatim Azaryah, Mireia Escudero-Marín, Andrés Catena, Camila M Snitman, Francisco J. Torres-Espínola, Cristina Campoy, Daniel Campos, [Campos,D, Escudero-Marín,M, Torres-Espínola,FJ, Azaryah,H, Campoy,C] Department of Paediatrics, School of Medicine, University of Granada, Granada, Spain. [Campos,D, Snitman,CM, Campoy,C] EURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, University of Granada, Granada, Spain. [Catena,A] Mind, Brain and Behaviour International Research Centre (CIMCYC), University of Granada, Granada, Spain. [Campoy,C] Instituto de Investigación Biosanitaria de Granada (Ibs-GRANADA), Granada, Spain. [Campoy,C] Spanish Network of Biomedical Research in Epidemiology and Public Health (CIBERESP), Granada’s Node, Institute of Health Carlos III, Madrid, Spain., and This work was supported by the Commission of the European Community’s 7th Framework Programme (FP7/2008-2013), grant agreement no. 212652 (NUTRIMENTHE project), within the 6th Framework Programme, contract no. 007036 (EARNEST project), and supported in part by the Commission of the European Community within the 5th Framework Programme, contract no. QLK1-CT-1999-00888 (NUHEAL project). This publication is the work of the authors and does not necessarily reflect the views of the Commission of the European Community. The funders had no role in the design, analysis or writing of this article.
- Subjects
Preferencias alimentarias ,030209 endocrinology & metabolism ,Publicidad ,Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Feeding Behavior [Medical Subject Headings] ,Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Feeding Behavior::Food Preferences [Medical Subject Headings] ,Childhood obesity ,Article ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] ,03 medical and health sciences ,Screen time ,0302 clinical medicine ,Obesidad pediátrica ,Tiempo de pantalla ,medicine ,Persons::Persons::Age Groups::Child [Medical Subject Headings] ,030212 general & internal medicine ,Food preferences ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Prevalence [Medical Subject Headings] ,Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings] ,Government ,School age child ,lcsh:RJ1-570 ,Health Care::Health Care Economics and Organizations::Organizations::Government [Medical Subject Headings] ,lcsh:Pediatrics ,Advertising ,medicine.disease ,3. Good health ,Unhealthy food ,Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity::Pediatric Obesity [Medical Subject Headings] ,Information Science::Information Science::Communications Media::Mass Media::Television [Medical Subject Headings] ,screen time ,Pediatrics, Perinatology and Child Health ,Technology and Food and Beverages::Technology, Industry, and Agriculture::Commerce::Marketing::Advertising as Topic [Medical Subject Headings] ,Psychology ,childhood obesity ,food preferences - Abstract
The prevalence of childhood obesity continues to increase. Screen time, one of the most documented reasons for the obesogenic environment, enhances childhood obesity, since advertisements for unhealthy food products are still broadcast on channels for children. This is presently one of the main challenges for the government in Spain, since the current laws and obligations are not updated. This study aims to analyze food advertising aimed at children on Spanish television in 2013 and 2018 on children&rsquo, s and general channels to test the effect of laws and obligations over time. In total, we viewed 512 h of the most viewed channels, two children&rsquo, s and two general channels, during the week and on weekends during specific periods of 2013 and 2018. Food advertising was categorized as core, non-core, and other food advertisement (CFA, NCFA, and OFA, respectively) according to the nutritional profile. A total of 2935 adverts were analyzed, 1263 in 2013 and 1672 in 2018. A higher proportion of NCFAs were broadcast on children&rsquo, s channels than in prior years, rising from 52.2% to 69.8% (p <, 0.001). Nowadays, the risk of watching NCFAs on children&rsquo, s channels compared to general channels turns out to be higher (Odds ratio >, 2.5, p <, 0.001), due to exposure to adverts for high-sugar and high-fat foods such as cakes, muffins, cookies, and fried and frozen meals rich in fat. In conclusion, the trends of nutritional profiles in food advertising on television are worsening over time, since the prevalence of NCFAs was higher in 2018 than in 2013. Currently, CFAs are not mainly broadcast on children&rsquo, s channels, confirming high-risk exposure to non-core food advertising by watching them. Thus, food advertising laws and obligations should be adapted to increase compliance.
- Published
- 2020
78. Effects of Maternal Fish Oil and/or 5-Methyl-Tetrahydrofolate Supplementation during Pregnancy on Offspring Brain Resting-State at 10 Years Old: A Follow-Up Study from the NUHEAL Randomized Controlled Trial
- Author
-
Cristina Martínez-Zaldívar, Andrés Catena, Cristina Martín-Pérez, Berthold Koletzko, Daniel Campos, Miguel Pérez-García, José Antonio García-Santos, Cristina Campoy, Hatim Azaryah, Francisco J. Torres-Espínola, Juan Verdejo-Román, [Azaryah,H, García-Santos,JA, Martínez-Zaldívar,C, Torres-Espínola,FJ, Campos,D, Campoy,C] Department of Paediatrics, School of Medicine, University of Granada, Granada, Spain. [Azaryah,H, Campoy,C] EURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, University of Granada, Granada, Spain. [Verdejo-Román,J, Martin-Pérez,C, Pérez-García,M, Catena,A] Mind, Brain and Behaviour International Research Centre (CIMCYC), University of Granada, Granada, Spain. [García-Santos,JA, Campoy,C] Instituto de Investigación Biosanitaria de Granada (Ibs-GRANADA), Health Sciences Technological Park, Granada, Spain. [Koletzko,B] Ludwig-Maximiliams-Universität München, Dr. von Hauner Children’s Hospital, University of Munich Hospitals, Munich, Germany. [Campoy,C] Spanish Network of Biomedical Research in Epidemiology and Public Health (CIBERESP), Granada’s Node, Institute of Health Carlos III, Madrid, Spain., This work was supported by the Commission of the European Community’s 7th Framework Program (FP7/2008–2013), Grant agreement No. 212652 (NUTRIMENTHE Project), within the 6th Framework Program, Contract no. 007036 (EARNEST Project), and and supported in part by the Commission of the European Community within the 5th Framework Program, Contract No. QLK1-CT-1999-00888 (NUHEAL EU Project). This publication is the work of the authors and does not necessarily reflect the views of the Commission of the European Community. The work of B.K. is supported by the European Research Council Advanced Grant ERC-2012-AdG-No.322605 META-GROWTH. J.V.-R is supported by a grant from the Spanish Ministry of Science, Innovation and Universities (FJCI-2017-33396). The funders had no role in the design, analysis or writing of this article.
- Subjects
Male ,0301 basic medicine ,Fish oils ,Folate ,Neurodevelopment ,Physiology ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Magnetic Resonance Imaging [Medical Subject Headings] ,Brain function ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Principal Component Analysis [Medical Subject Headings] ,fish oil ,law.invention ,Resting-state functional neuroimaging ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] ,Child Development ,0302 clinical medicine ,Randomized controlled trial ,law ,Pregnancy ,Aceites de pescado ,Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure::Maternal Exposure [Medical Subject Headings] ,Child ,Children ,Tetrahydrofolates ,Default mode network ,Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy [Medical Subject Headings] ,Principal Component Analysis ,Nutrition and Dietetics ,Maternal nutritional physiological phenomena ,Fenómenos fisiologicos nutricionales maternos ,neurodevelopment ,Neuropsychology ,Brain ,Magnetic Resonance Imaging ,3. Good health ,Maternal Exposure ,Niño ,Technology and Food and Beverages::Food and Beverages::Food::Dietary Supplements [Medical Subject Headings] ,Regression Analysis ,Female ,Ácido fólico ,pregnancy ,lcsh:Nutrition. Foods and food supply ,Adult ,Anthropology, Education, Sociology and Social Phenomena::Human Activities::Leisure Activities::Relaxation::Rest [Medical Subject Headings] ,Anatomy::Nervous System::Nerve Net [Medical Subject Headings] ,Offspring ,Embarazo ,Phenomena and Processes::Physiological Phenomena::Physiological Processes::Growth and Development::Human Development::Child Development [Medical Subject Headings] ,Rest ,Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Pteridines::Pterins::Folic Acid::Tetrahydrofolates [Medical Subject Headings] ,Check Tags::Male [Medical Subject Headings] ,lcsh:TX341-641 ,Fish oil ,Placebo ,folate ,Article ,Angular gyrus ,brain function ,03 medical and health sciences ,Fish Oils ,children ,Chemicals and Drugs::Lipids::Oils::Fish Oils [Medical Subject Headings] ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up Studies [Medical Subject Headings] ,medicine ,Humans ,Persons::Persons::Age Groups::Child [Medical Subject Headings] ,Persons::Persons::Age Groups::Adult [Medical Subject Headings] ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Regression Analysis [Medical Subject Headings] ,030109 nutrition & dietetics ,Resting state fMRI ,Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Maternal Nutritional Physiological Phenomena [Medical Subject Headings] ,business.industry ,resting-state functional neuroimaging ,Maternal Nutritional Physiological Phenomena ,Anatomy::Nervous System::Central Nervous System::Brain [Medical Subject Headings] ,medicine.disease ,Check Tags::Female [Medical Subject Headings] ,Dietary Supplements ,Nerve Net ,business ,030217 neurology & neurosurgery ,Follow-Up Studies ,Food Science - Abstract
Recent studies have shown that maternal supplementation with folate and long-chain polyunsaturated fatty acids (LC-PUFAs) during pregnancy may affect children&rsquo, s brain development. We aimed at examining the potential long-term effect of maternal supplementation with fish oil (FO) and/or 5-methyl-tetrahydrofolate (5-MTHF) on the brain functionality of offspring at the age of 9.5&ndash, 10 years. The current study was conducted as a follow-up of the Spanish participants belonging to the Nutraceuticals for a Healthier Life (NUHEAL) project, 57 children were divided into groups according to mother&rsquo, s supplementation and assessed through functional magnetic resonance imaging (fMRI) scanning and neurodevelopment testing. Independent component analysis and double regression methods were implemented to investigate plausible associations. Children born to mothers supplemented with FO (FO and FO + 5-MTHF groups, n = 33) showed weaker functional connectivity in the default mode (DM) (angular gyrus), the sensorimotor (SM) (motor and somatosensory cortices) and the fronto-parietal (FP) (angular gyrus) networks compared to the No-FO group (placebo and 5-MTHF groups, n = 24) (PFWE <, 0.05). Furthermore, no differences were found regarding the neuropsychological tests, except for a trend of better results in an object recall (memory) test. Considering the No-FO group, the aforementioned networks were associated negatively with attention and speed-processing functions. Mother&rsquo, s FO supplementation during pregnancy seems to be able to shape resting-state network functioning in their children at school age and appears to produce long-term effects on children´, s cognitive processing.
- Published
- 2020
- Full Text
- View/download PDF
79. Probiotics and Preterm Infants: A Position Paper by the European Society for Paediatric Gastroenterology Hepatology and Nutrition Committee on Nutrition and the European Society for Paediatric Gastroenterology Hepatology and Nutrition Working Group for Probiotics and Prebiotics
- Author
-
Nicholas D. Embleton, Jiri Bronsky, Yvan Vandenplas, Sanja Kolaček, Cristina Campoy, Flavia Indrio, Raanan Shamir, Mary Fewtrell, Alexandre Lapillonne, Walter A. Mihatsch, Magnus Domellöf, Jessie M. Hulst, Alfredo Guarino, Rok Orel, Johannes B. van Goudoever, Nataša Fidler Mis, Chris H.P. van den Akker, Roberto Berni Canani, Iva Hojsak, Zvi Weizman, Hania Szajewska, Neonatology, AGEM - Digestive immunity, AGEM - Endocrinology, metabolism and nutrition, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, ARD - Amsterdam Reproduction and Development, Clinical sciences, Growth and Development, Pediatrics, Pediatric surgery, ACS - Diabetes & metabolism, and Amsterdam Reproduction & Development (AR&D)
- Subjects
medicine.medical_specialty ,Bifidobacterium lactis ,law.invention ,Sepsis ,03 medical and health sciences ,Probiotic ,0302 clinical medicine ,Lactobacillus rhamnosus ,Paediatric gastroenterology ,law ,Enterocolitis, Necrotizing ,030225 pediatrics ,Internal medicine ,Medicine ,Humans ,Pediatrics, Perinatology, and Child Health ,Intensive care medicine ,Child ,Nutrition ,Enterocolitis ,biology ,Paediatric Gastroenterology ,business.industry ,Gastroenterology ,Infant, Newborn ,Infant ,Preterm infants ,Hepatology ,medicine.disease ,biology.organism_classification ,probiotics ,hepatology ,Pediatrics, Perinatology and Child Health ,Position paper ,030211 gastroenterology & hepatology ,medicine.symptom ,business ,prebiotics ,Infant, Premature - Abstract
More than 10,000 preterm infants have participated in randomised controlled trials on probiotics worldwide, suggesting that probiotics in general could reduce rates of necrotising enterocolitis (NEC), sepsis, and mortality. Answers to relevant clinical questions as to which strain to use, at what dosage, and how long to supplement are, however, not available. On the other hand, an increasing number of commercial products containing probiotics are available from sometimes suboptimal quality. Also, a large number of units around the world are routinely offering probiotic supplementation as the standard of care despite lacking solid evidence. Our recent network meta-analysis identified probiotic strains with greatest efficacy regarding relevant clinical outcomes for preterm neonates. Efficacy in reducing mortality and morbidity was found for only a minority of the studied strains or combinations. In the present position paper, we aim to provide advice, which specific strains might potentially be used and which strains should not be used. In addition, we aim to address safety issues of probiotic supplementation to preterm infants, who have reduced immunological capacities and occasional indwelling catheters. For example, quality reassurance of the probiotic product is essential, probiotic strains should be devoid of transferable antibiotic resistance genes, and local microbiologists should be able to routinely detect probiotic sepsis. Provided all safety issues are met, there is currently a conditional recommendation (with low certainty of evidence) to provide either Lactobacillus rhamnosus GG ATCC53103 or the combination of Bifidobacterium infantis Bb-02, Bifidobacterium lactis Bb-12, and Streptococcus thermophilus TH-4 in order to reduce NEC rates.
- Published
- 2020
80. Influence of a Functional Nutrients-Enriched Infant Formula on Language Development in Healthy Children at Four Years Old
- Author
-
Mercedes G. Bermúdez, José Antonio García-Santos, Andrés Catena, M. Teresa Miranda, Natalia Sepúlveda-Valbuena, Jesús Jiménez, Estefanía Diéguez, María Rodríguez-Palmero, Cristina Campoy, Ana Nieto-Ruiz, and Elvira Catena
- Subjects
0301 basic medicine ,Male ,Pediatrics ,medicine.medical_specialty ,breastfeeding ,Breastfeeding ,lcsh:TX341-641 ,Logistic regression ,Article ,03 medical and health sciences ,0302 clinical medicine ,Child Development ,Double-Blind Method ,Standard infant formula ,030225 pediatrics ,Medicine ,Humans ,functional nutrients ,Prospective Studies ,Language development ,Infant Nutritional Physiological Phenomena ,Socioeconomic status ,Reference group ,030109 nutrition & dietetics ,Nutrition and Dietetics ,business.industry ,Infant, Newborn ,Infant ,Cognition ,infant formula ,Nutrients ,3. Good health ,Infant formula ,Child, Preschool ,Dietary Supplements ,Food, Fortified ,Female ,business ,lcsh:Nutrition. Foods and food supply ,Functional nutrients ,language development ,Child Language ,Food Science - Abstract
Nutrition during early life is essential for brain development and establishes the basis for cognitive and language skills development. It is well established that breastfeeding, compared to formula feeding, has been traditionally associated with increased neurodevelopmental scores up to early adulthood. We analyzed the long-term effects of a new infant formula enriched with bioactive compounds on healthy children&rsquo, s language development at four years old. In a randomized double-blind COGNIS study, 122 children attended the follow-up call at four years. From them, 89 children were fed a standard infant formula (SF, n = 46) or an experimental infant formula enriched with functional nutrients (EF, n = 43) during their first 18 months of life. As a reference group, 33 exclusively breastfed (BF) were included. Language development was assessed using the Oral Language Task of Navarra-Revised (PLON-R). ANCOVA, chi-square test, and logistic regression models were performed. EF children seemed to show higher scores in use of language and oral spontaneous expression than SF children, and both SF and EF groups did not differ from the BF group. Moreover, it seems that SF children were more frequently categorized into &ldquo, need to improve and delayed&rdquo, in the use of language than EF children, and might more frequently present &ldquo, in the PLON-R total score than BF children. Finally, the results suggest that SF children presented a higher risk of suffering language development than BF children. Secondary analysis also showed a slight trend between low socioeconomic status and poorer language skills. The functional compound-enriched infant formula seems to be associated with beneficial long-term effects in the development of child&rsquo, s language at four years old in a similar way to breastfed infants.
- Published
- 2020
81. Long-Chain Polyunsaturated Fatty Acids, Homocysteine at Birth and Fatty Acid Desaturase Gene Cluster Polymorphisms Are Associated with Children’s Processing Speed up to Age 9 Years
- Author
-
Miguel Pérez-García, Francisco J. Torres-Espínola, Peter Rzehak, Tamás Decsi, Eszter Györei, Hatim Azaryah, Cristina Martínez-Zaldívar, Anne M. Molloy, Eva Reischl, Cristina Campoy, G. Haile, Maria del Carmen Ramirez-Tortosa, José Antonio García-Santos, Hans Demmelmair, Juan de Dios Luna, and Berthold Koletzko
- Subjects
Fatty Acid Desaturases ,Male ,0301 basic medicine ,Folate ,prenatal supplementation ,Homocysteine ,chemistry.chemical_compound ,Child Development ,Cognition ,Delta-5 Fatty Acid Desaturase ,0302 clinical medicine ,Pregnancy ,processing speed ,Child ,Infant Nutritional Physiological Phenomena ,Children ,Tetrahydrofolates ,2. Zero hunger ,chemistry.chemical_classification ,Nutrition and Dietetics ,neurodevelopment ,biology ,Brain ,Fetal Blood ,FADS gene ,Docosahexaenoic acid ,Prenatal supplementation ,Multigene Family ,Female ,Arachidonic acid ,Processing speed ,lcsh:Nutrition. Foods and food supply ,Maternal Age ,Polyunsaturated fatty acid ,Adult ,medicine.medical_specialty ,Docosahexaenoic Acids ,FADS1 ,Offspring ,Long chain polyunsaturated fatty acids ,lcsh:TX341-641 ,030209 endocrinology & metabolism ,Neurodevelopme ,folate ,Article ,long-chain polyunsaturated fatty acids ,Young Adult ,03 medical and health sciences ,children ,Internal medicine ,medicine ,Humans ,Methylenetetrahydrofolate Reductase (NADPH2) ,Polymorphism, Genetic ,030109 nutrition & dietetics ,business.industry ,Infant, Newborn ,Maternal Nutritional Physiological Phenomena ,Endocrinology ,Fatty acid desaturase ,chemistry ,Methylenetetrahydrofolate reductase ,Dietary Supplements ,Stroop Test ,biology.protein ,business ,Fads Gene ,Long-chain Polyunsaturated Fatty Acids ,Neurodevelopment ,Prenatal Supplementation ,Processing Speed ,Follow-Up Studies ,Food Science - Abstract
Both pre- and early postnatal supplementation with docosahexaenoic acid (DHA), arachidonic acid (AA) and folate have been related to neural development, but their long-term effects on later neural function remain unclear. We evaluated the long-term effects of maternal prenatal supplementation with fish-oil (FO), 5-methyltetrahydrofolate (5-MTHF), placebo or FO + 5-MTHF, as well as the role of fatty acid desaturase (FADS) gene cluster polymorphisms, on their offspring’s processing speed at later school age. This study was conducted in NUHEAL children at 7.5 (n = 143) and 9 years of age (n = 127). Processing speed tasks were assessed using Symbol Digit Modalities Test (SDMT), Children Color Trails Test (CCTT) and Stroop Color andWord Test (SCWT). Long-chain polyunsaturated fatty acids, folate and total homocysteine (tHcy) levels were determined at delivery from maternal and cord blood samples. FADS and methylenetetrahydrofolate reductase (MTHFR) 677 C > T genetic polymorphisms were analyzed. Mixed models (linear and logistic) were performed. There were significant differences in processing speed performance among children at different ages (p < 0.001). The type of prenatal supplementation had no effect on processing speed in children up to 9 years. Secondary exploratory analyses indicated that children born to mothers with higher AA/DHA ratio at delivery (p < 0.001) and heterozygotes for FADS1 rs174556 (p < 0.05) showed better performance in processing speed at 9 years. Negative associations between processing speed scores and maternal tHcy levels at delivery were found. Our findings suggest speed processing development in children up to 9 years could be related to maternal factors, including AA/DHA and tHcy levels, and their genetic background, mainly FADS polymorphism. These considerations support that maternal prenatal supplementation should be quantitatively adequate and individualized to obtain better brain development and mental performance in the offspring., European Commission 212652 007036 QLK1-CT-1999-00888, European Commission European Commission Joint Research Centre DYNAHEALTH-633595 Lifecycle-733206, European Research Council Advanced Grant META-GROWTH ERC-2012AdG 322605, Erasmus Plus Programme Early Nutrition eAcademy Southeast Asia 573651EPP-1-2016-1-DE-EPPKA2-CBHE-JP, Erasmus Plus Programme Capacity Building to Improve Early Nutrition and Health in South Africa 598488-EPP-1-2018-1-DE-EPPKA2-CBHE-JP, EU Interreg Programme Focus in CD-CE111, European Joint Programming Initiative Project NutriPROGRAM and EndObesity, German Ministry of Education and Research, Berlin 01 GI 0825, German Research Foundation (DFG) Ko912/12-1 INST 409/224-1 FUGG, Else Kroner-Fresenius-Foundation, LMU University Hospitals
- Published
- 2020
82. Gut microbial functional maturation and succession during human early life
- Author
-
Antonio Suárez, Sven-Bastian Haange, Alicia Ruiz, Inmaculada Acuña, Ruy Jauregui, Martin von Bergen, Tomás Cerdó, Nico Jehmlich, and Cristina Campoy
- Subjects
Proteomics ,0301 basic medicine ,Zoology ,Biology ,Gut flora ,Bacterial Physiological Phenomena ,Microbiology ,Feces ,03 medical and health sciences ,Bacterial Proteins ,Phylogenetics ,Abundance (ecology) ,RNA, Ribosomal, 16S ,Animals ,Humans ,Phylogeny ,Ecology, Evolution, Behavior and Systematics ,Facultative ,Bacteria ,Microbiota ,Lachnospiraceae ,Infant, Newborn ,Infant ,Obligate anaerobe ,biology.organism_classification ,Gastrointestinal Microbiome ,030104 developmental biology ,Microbial population biology ,Fermentation ,Metaproteomics ,Carbohydrate Metabolism ,Bifidobacterium - Abstract
The evolutional trajectory of gut microbial colonization from birth has been shown to prime for health later in life. Here, we combined cultivation-independent 16S rRNA gene sequencing and metaproteomics to investigate the functional maturation of gut microbiota in faecal samples from full-term healthy infants collected at 6 and 18 months of age. Phylogenetic analysis of the metaproteomes showed that Bifidobacterium provided the highest number of distinct protein groups. Considerable divergences between taxa abundance and protein phylogeny were observed at all taxonomic ranks. Age had a profound effect on early microbiota where compositional and functional diversity of less dissimilar communities increased with time. Comparisons of the relative abundances of proteins revealed the transition of taxon-associated saccharolytic and fermentation strategies from milk and mucin-derived monosaccharide catabolism feeding acetate/propanoate synthesis to complex food-derived hexoses fuelling butanoate production. Furthermore, co-occurrence network analysis uncovered two anti-correlated modules of functional taxa. A low-connected Bifidobacteriaceae-centred guild of facultative anaerobes was succeeded by a rich club of obligate anaerobes densely interconnected around Lachnospiraceae, underpinning their pivotal roles in microbial ecosystem assemblies. Our findings establish a framework to visualize whole microbial community metabolism and ecosystem succession dynamics, proposing opportunities for microbiota-targeted health-promoting strategies early in life.
- Published
- 2018
83. Changes in plasma fatty acid composition are associated with improvements in obesity and related metabolic disorders: A therapeutic approach to overweight adolescents
- Author
-
Luis A. Moreno, Ana I. Castellote, Marcela Guerendiain, Miguel Martín-Matillas, E Martin-Bautista, Javier Caballero, Gemma López-Belmonte, Cristina Campoy, Rosa Montes, J. Alfredo Martínez, M. Carmen López-Sabater, Amelia Marti, Ascensión Marcos, Julia Wärnberg, J. M. Garagorri, Ministerio de Sanidad y Consumo (España), and Instituto de Salud Carlos III
- Subjects
Male ,0301 basic medicine ,Weight loss ,medicine.medical_specialty ,Adolescent ,030209 endocrinology & metabolism ,Overweight ,Critical Care and Intensive Care Medicine ,03 medical and health sciences ,0302 clinical medicine ,Plasma fatty acids ,Internal medicine ,Weight Loss ,Humans ,Medicine ,Obesity ,Child ,Adiposity ,chemistry.chemical_classification ,030109 nutrition & dietetics ,Nutrition and Dietetics ,business.industry ,Fatty Acids ,food and beverages ,medicine.disease ,Eicosapentaenoic acid ,Weight Reduction Programs ,Cardiometabolic profile ,Endocrinology ,chemistry ,Docosahexaenoic acid ,Saturated fatty acid ,Female ,lipids (amino acids, peptides, and proteins) ,Obese adolescents ,medicine.symptom ,business ,Body mass index ,Polyunsaturated fatty acid - Abstract
EVASYON Study Group., [Background & aims]: In recent years, obesity has reached alarming levels among children and adolescents. The study of plasma fatty acid (FA) composition, as a reflection of diet, and its associations with other parameters, that are closely linked to obesity and the cardiometabolic profile, may be useful for setting nutritional goals for obesity treatment and prevention. This study explored the relationship between plasma FA levels and body fat and cardiometabolic risk markers, in overweight adolescents. [Methods]: A multidisciplinary weight loss program was followed by 127 overweight and obese adolescents aged 12–17 years old. Plasma FA composition, anthropometric indicators of adiposity and biochemical parameters were analyzed at baseline, two months (the end of the intensive intervention phase) and six months (the end of the extensive phase). [Results]: While saturated fatty acid (SFA) and n-6 polyunsaturated fatty acid (PUFA) levels decreased significantly during the intervention, monounsaturated fatty acid (MUFA) and n-3 PUFA showed the opposite trend. The decrease in SFA C14:0 was associated with a reduction in total and LDL cholesterol, apolipoprotein B and insulin. The increase in MUFAs, especially C18:1n-9, was related to a reduction in weight, fat mass, fat mass index and glucose. Regarding PUFAs, changes in the n-3 series were not associated with any of the parameters studied, whereas the reduction in n-6 PUFAs was directly related to weight, fat mass, total and HDL cholesterol, apolipoprotein A1, glucose and insulin, and inversely associated with diastolic blood pressure. The adolescents with greater weight loss presented significant changes in MUFAs, n-6 PUFAs and C14:0. [Conclusions]: Modifications in plasma FA composition were associated with adiposity reduction and cardiometabolic profile improvement in an anti-obesity program aimed at adolescents. The changes observed in FA composition were related to the success of the treatment, since the individuals most affected by these variations were those who presented the greatest weight loss., This work is part of the EVASYON study funded by the Spanish Ministry of Health and Consumption (Carlos III Institute of Health. FIS. Grant PI 051579).
- Published
- 2018
84. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Lipids
- Author
-
Alexandre Lapillonne, Nataša Fidler Mis, Olivier Goulet, Chris H.P. van den Akker, Jennifer Wu, Berthold Koletzko, Christian Braegger, Jiri Bronsky, Wei Cai, Cristina Campoy, Virgilio Carnielli, Dominique Darmaun, Tamás Decsi, Magnus Domellöf, Nicholas Embleton, Mary Fewtrell, Axel Franz, Corina Hartman, Susan Hill, Iva Hojsak, Silvia Iacobelli, Frank Jochum, Koen Joosten, Sanja Kolaček, Janusz Ksiazyk, Szimonetta Lohner, Dieter Mesotten, Krisztina Mihályi, Walter A. Mihatsch, Francis Mimouni, Christian Mølgaard, Sissel J. Moltu, Antonia Nomayo, Jean Charles Picaud, Christine Prell, John Puntis, Arieh Riskin, Miguel Saenz De Pipaon, Thibault Senterre, Raanan Shamir, Venetia Simchowitz, Peter Szitanyi, Merit M. Tabbers, Chris H.B. Van Den Akker, Johannes B. Van Goudoever, Anne Van Kempen, Sascha Verbruggen, Jiang Wu, Weihui Yan, CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Baylor College of Medicine (BCM), University Medical Centre Ljubljana [Ljubljana, Slovenia] (UMCL), University of Amsterdam [Amsterdam] (UvA), Shanghai Jiaotong University, University of Munich Medical Center, Partenaires INRAE, Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes (UN)-Institut National de la Recherche Agronomique (INRA), Pediatrics, Neonatology, ARD - Amsterdam Reproduction and Development, AGEM - Digestive immunity, Paediatric Gastroenterology, AGEM - Re-generation and cancer of the digestive system, University of Zurich, Lapillonne, Alexandre, Pediatric surgery, ACS - Diabetes & metabolism, AGEM - Endocrinology, metabolism and nutrition, and Amsterdam Reproduction & Development (AR&D)
- Subjects
0301 basic medicine ,Fat Emulsions, Intravenous ,Parenteral Nutrition ,medicine.medical_specialty ,Critical Illness ,610 Medicine & health ,Critical Care and Intensive Care Medicine ,03 medical and health sciences ,0302 clinical medicine ,Cholestasis ,parenteral nutrition ,lipid/fat emulsions ,paediatric ,fatty acids ,LC-PUFA ,IFALD ,PNALD ,cholestasis ,030225 pediatrics ,medicine ,Humans ,Child ,Intensive care medicine ,ComputingMilieux_MISCELLANEOUS ,030109 nutrition & dietetics ,Nutrition and Dietetics ,business.industry ,Poisoning ,Infant, Newborn ,Infant ,medicine.disease ,Lipids ,3. Good health ,Parenteral nutrition ,10036 Medical Clinic ,Child, Preschool ,2916 Nutrition and Dietetics ,lipids (amino acids, peptides, and proteins) ,Child Nutritional Physiological Phenomena ,business ,2706 Critical Care and Intensive Care Medicine ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition ,Infant, Premature ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Lipids
- Published
- 2018
85. ESPGHAN/ESPEN/ESPR guidelines on pediatric parenteral nutrition: Energy
- Author
-
Magnus Domellöf, Miguel Saenz de Pipaon, Koen F. M. Joosten, Johannes B. van Goudoever, Nicholas D. Embleton, Silvia Iacobelli, Berthold Koletzko, Francis B. Mimouni, Arieh Riskin, Wei Cai, Weihui Yan, John W L Puntis, K. Joosten, Jiang Wu, Christian Braegger, Alexandre Lapillonne, Raanan Shamir, Venetia Simchowitz, Sissel J. Moltu, Frank Jochum, Antonia Nomayo, W. Yan, Dieter Mesotten, Anne A.M.W. van Kempen, Olivier Goulet, T. Senterre, Dominique Darmaun, Peter Szitanyi, Virgilio P. Carnielli, Christian Mølgaard, Sascha Bruggen, Sanja Kolaček, N. Embleton, Cristina Campoy, Mary Fewtrell, Susan Hill, Axel R. Franz, Iva Hojsak, Corina Hartman, Merit M. Tabbers, Tamás Decsi, Thibault Senterre, Janusz Ksiazyk, Szimonetta Lohner, Christine Prell, Jean Charles Picaud, Chris H. B. van den Akker, Walter A. Mihatsch, Nataša Fidler Mis, Krisztina Mihalyi, Jiri Bronsky, Sophia Children's Hospital, Newcastle University [Newcastle], Shanghai Jiaotong University, Université de Liège, Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes (UN)-Institut National de la Recherche Agronomique (INRA), ARD - Amsterdam Reproduction and Development, AGEM - Digestive immunity, Paediatric Gastroenterology, AGEM - Re-generation and cancer of the digestive system, Neonatology, Pediatrics, Pediatric surgery, ACS - Diabetes & metabolism, AGEM - Endocrinology, metabolism and nutrition, and Amsterdam Reproduction & Development (AR&D)
- Subjects
0301 basic medicine ,Parenteral Nutrition ,medicine.medical_specialty ,Adolescent ,Energy metabolism ,MEDLINE ,Critical Care and Intensive Care Medicine ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Medicine ,030212 general & internal medicine ,Child ,Intensive care medicine ,ComputingMilieux_MISCELLANEOUS ,030109 nutrition & dietetics ,Nutrition and Dietetics ,Energy ,business.industry ,Infant, Newborn ,Infant ,Pediatric parenteral nutrition ,Parenteral nutrition ,Child, Preschool ,Child Nutritional Physiological Phenomena ,Energy Metabolism ,business ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition ,Infant, Premature ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Energy
- Published
- 2018
86. ESPGHAN/ESPEN/ESPR guidelines on pediatric parenteral nutrition: Standard versus individualized parenteral nutrition
- Author
-
Arieh Riskin, Jean-Charles Picaud, Raanan Shamir, Christian Braegger, Jiri Bronsky, Wei Cai, Cristina Campoy, Virgilio Carnielli, Dominique Darmaun, Tamás Decsi, Magnus Domellöf, Nicholas Embleton, Mary Fewtrell, Nataša Fidler Mis, Axel Franz, Olivier Goulet, Corina Hartman, Susan Hill, Iva Hojsak, Silvia Iacobelli, Frank Jochum, Koen Joosten, Sanja Kolaček, Berthold Koletzko, Janusz Ksiazyk, Alexandre Lapillonne, Szimonetta Lohner, Dieter Mesotten, Krisztina Mihályi, Walter A. Mihatsch, Francis Mimouni, Christian Mølgaard, Sissel J. Moltu, Antonia Nomayo, Jean Charles Picaud, Christine Prell, John Puntis, Miguel Saenz De Pipaon, Thibault Senterre, Venetia Simchowitz, Peter Szitanyi, Merit M. Tabbers, Chris H.B. Van Den Akker, Johannes B. Van Goudoever, Anne Van Kempen, Sascha Verbruggen, Jiang Wu, Weihui Yan, ARD - Amsterdam Reproduction and Development, AGEM - Digestive immunity, Paediatric Gastroenterology, AGEM - Re-generation and cancer of the digestive system, Neonatology, Technion - Israel Institute of Technology, Hospices Civils de Lyon (HCL), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Tel Aviv University [Tel Aviv], Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes (UN)-Institut National de la Recherche Agronomique (INRA), Pediatrics, Technion - Israel Institute of Technology [Haifa], Pediatric surgery, ACS - Diabetes & metabolism, AGEM - Endocrinology, metabolism and nutrition, and Amsterdam Reproduction & Development (AR&D)
- Subjects
0301 basic medicine ,Parenteral Nutrition ,medicine.medical_specialty ,Adolescent ,MEDLINE ,Critical Care and Intensive Care Medicine ,standard parenteral nutrition ,individualized parenteral nutrition ,individually-tailored or prescribed parenteral nutrition ,computerized prescription ,premature or preterm infants ,very-low-birthweight infants ,pediatric patients ,infants ,children ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Humans ,Medicine ,Precision Medicine ,Child ,Intensive care medicine ,ComputingMilieux_MISCELLANEOUS ,2. Zero hunger ,030109 nutrition & dietetics ,Nutrition and Dietetics ,business.industry ,Infant, Newborn ,Infant ,Precision medicine ,3. Good health ,Parenteral nutrition ,Child, Preschool ,Child Nutritional Physiological Phenomena ,business ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition : Standard versus individualized parenteral nutrition
- Published
- 2018
87. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition
- Author
-
Christine Prell, Dominique Darmaun, Walter A. Mihatsch, Anne A.M.W. van Kempen, Venetia Simchowitz, Corina Hartman, Silvia Iacobelli, Krisztina Mihalyi, Berthold Koletzko, Mary Fewtrell, Sanja Kolaček, Arieh Riskin, Antonia Nomayo, Johannes B. van Goudoever, Dieter Mesotten, Nicholas D. Embleton, Virgilio P. Carnielli, Christian Braegger, Francis B. Mimouni, Frank Jochum, Jiri Bronsky, Chris H. B. van den Akker, Sissel J. Moltu, Olivier Goulet, Weihui Yan, Koen F. M. Joosten, Janusz Ksiazyk, John W L Puntis, Jean-Charles Picaud, Szimonetta Lohner, Alexandre Lapillonne, Ranaan Shamir, Tamas Desci, Hill Susan, Cristina Campoy, Merit M. Tabbers, Magnus Domellöf, Miguel Saenz de Pipaon, Jiang Wu, Thibault Senterre, Iva Hojsak, Axel Franz, Peter Szitanyi, Christian Mølgaard, Nataša Fidler Mis, Sascha Verbruggen, Wei Cai, Universität Ulm - Ulm University [Ulm, Allemagne], University Children’s Hospital Zurich, University Hospital Motol [Prague], Shanghai Jiao Tong University [Shanghai], Universidad de Granada = University of Granada (UGR), Polytechnic University of Marche, Université de Nantes (UN), University of Pecs, Umeå University, University of Newcastle upon Tyne, NHS Foundation Trust, University Medical Centre Ljubljana [Ljubljana, Slovenia] (UMCL), University Children's Hospital, Université Paris Descartes - Paris 5 (UPD5), Schneider Children's Medical Center of Israel, Children's Hospital Zagreb, Centre Hospitalier Universitaire de La Réunion (CHU La Réunion), Evangelisches Waldkrankenhaus Spandau, Partenaires INRAE, Eramus MC-Sophia Children’s Hospital, Ludwig-Maximilians University [Munich] (LMU), The Children’s Memorial Health Institute, Katholieke Universiteit Leuven, Department of Pediatrics-Division of Neonatology, University of Alberta, University of Copenhagen = Københavns Universitet (UCPH), Oslo University Hospital [Oslo], Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), The General Infirmary at Leeds, Bnai Zion Medical Center, Hospital Universitario La Paz, Centre Hospitalier Universitaire de Liège (CHU-Liège), General University Hospital in Prague, Emma Children’s Hospital Academic Medical Centre, OLVG Hospital, Xinhua Hospital, ProdInra, Migration, Pediatrics, Pediatric surgery, ACS - Diabetes & metabolism, AGEM - Endocrinology, metabolism and nutrition, Amsterdam Reproduction & Development (AR&D), University of Granada, Ludwig Maximilians University of Munich, University of Copenhagen = Københavns Universitet (KU), Paediatric Gastroenterology, AGEM - Digestive immunity, AGEM - Re-generation and cancer of the digestive system, ARD - Amsterdam Reproduction and Development, and Neonatology
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Adolescent ,MEDLINE ,parenteral nutrition ,Clinical nutrition ,Critical Care and Intensive Care Medicine ,03 medical and health sciences ,[SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics ,0302 clinical medicine ,030225 pediatrics ,medicine ,Humans ,Guideline development ,Child ,[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics ,030109 nutrition & dietetics ,Nutrition and Dietetics ,business.industry ,Infant, Newborn ,Consensus conference ,Infant ,Guideline ,Chinese society ,Evidence level ,3. Good health ,[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition ,Parenteral nutrition ,Child, Preschool ,Family medicine ,Practice Guidelines as Topic ,Child Nutritional Physiological Phenomena ,business ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition - Abstract
International audience; Background: Previous guidelines on Paediatric Parenteral Nutrition (PN) were published in 2010, by the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and the European Society for Clinical Nutrition and Metabolism (ESPEN), supported by the European Society of Paediatric Research (ESPR) were published. The aim of the present paper was to provide up-to-date evidence for health professionals working with infants, children and adolescents receiving PN. Methods: The current document is a revision of the 2005 guidelines produced by the same 3 organizations (ESPEN, ESPGHAN, ESPR) together with the Chinese Society of Parenteral and Enteral Nutrition (CSPEN). Experts participating in the guideline updating process were all professionals with extensive experience in managing PN from a wide range of European countries, Israel and China. The guideline development process was coordinated by a guideline steering committee. Each chapter of the guideline was prepared by a separate author group. These author groups were responsible for screening titles and abstracts identified by a systematic literature search for inclusion, for conducting additional expert searches (including secondary sources such as other published valid guidelines), for evaluating the quality of studies included in the given chapter and assigning evidence levels to the literature. Based on the evidence level of included studies experts formulated and graded recommendations. A consensus conference was held in February 2015. All chapter manuscripts were revised following the recommendations of the consensus conference and then reviewed and edited by the project steering committee. Final consensus on each individual guideline and its individual recommendations was achieved and assessed by online voting. This process lasted until January 2018. Funding for the consensus conference (including travel expenses for participants) was provided by all participating societies. No other funding was received for the guideline updating process and participants received no payment. Support was provided by the Hungarian Cochrane organization. Results/conclusions: The present document provides guideline for the use of PN across the wide range of pediatric patients, ranging from extremely premature infants up to teenagers weighing up to and over 100 kg [1]. It covers their individual macro- and micronutrient needs [2], [3], [4], [5], [6], [7], [8], fluid requirements [9], venous access [10], organizational aspects [11], home parenteral nutrition [12], standardized vs. individualized PN [13], and last but not least a wide range of safety considerations for prevention and management of complications such central line associated bloodstream infections (CLABSI)
- Published
- 2018
88. Infant formula enriched with milk fat globule membrane, long-chain polyunsaturated fatty acids, synbiotics, gangliosides, nucleotides and sialic acid reduces infections during the first 18 months of life: The COGNIS study
- Author
-
Jesús Jiménez, Ana Nieto-Ruiz, Cristina Campoy, Estefanía Diéguez, Florian Herrmann, Roser De-Castellar, M. Teresa Miranda, Mercedes G. Bermúdez, José Antonio García-Santos, Natalia Sepúlveda-Valbuena, María García-Ricobaraza, [Herrmann, Florian] Univ Granada, Dept Paediat, Sch Med, Avda Invest 11, Granada 18016, Spain, [Nieto-Ruiz, Ana] Univ Granada, Dept Paediat, Sch Med, Avda Invest 11, Granada 18016, Spain, [Sepulveda-Valbuena, Natalia] Univ Granada, Dept Paediat, Sch Med, Avda Invest 11, Granada 18016, Spain, [Dieguez, Estefania] Univ Granada, Dept Paediat, Sch Med, Avda Invest 11, Granada 18016, Spain, [Garcia-Ricobaraza, Maria] Univ Granada, Dept Paediat, Sch Med, Avda Invest 11, Granada 18016, Spain, [Garcia-Santos, Jose Antonio] Univ Granada, Dept Paediat, Sch Med, Avda Invest 11, Granada 18016, Spain, [Bermudez, Mercedes G.] Univ Granada, Dept Paediat, Sch Med, Avda Invest 11, Granada 18016, Spain, [Campoy, Cristina] Univ Granada, Dept Paediat, Sch Med, Avda Invest 11, Granada 18016, Spain, [Herrmann, Florian] Inst Invest Biosanitaria IbsGRANADA, Hlth Sci Technol Pk, Granada 18012, Spain, [Nieto-Ruiz, Ana] Inst Invest Biosanitaria IbsGRANADA, Hlth Sci Technol Pk, Granada 18012, Spain, [Dieguez, Estefania] Inst Invest Biosanitaria IbsGRANADA, Hlth Sci Technol Pk, Granada 18012, Spain, [Garcia-Ricobaraza, Maria] Inst Invest Biosanitaria IbsGRANADA, Hlth Sci Technol Pk, Granada 18012, Spain, [Garcia-Santos, Jose Antonio] Inst Invest Biosanitaria IbsGRANADA, Hlth Sci Technol Pk, Granada 18012, Spain, [Bermudez, Mercedes G.] Inst Invest Biosanitaria IbsGRANADA, Hlth Sci Technol Pk, Granada 18012, Spain, [Campoy, Cristina] Inst Invest Biosanitaria IbsGRANADA, Hlth Sci Technol Pk, Granada 18012, Spain, [Herrmann, Florian] Univ Granada, EURISTIKOS Excellence Ctr Paediat Res, Biomed Res Ctr, Granada 18016, Spain, [Nieto-Ruiz, Ana] Univ Granada, EURISTIKOS Excellence Ctr Paediat Res, Biomed Res Ctr, Granada 18016, Spain, [Sepulveda-Valbuena, Natalia] Univ Granada, EURISTIKOS Excellence Ctr Paediat Res, Biomed Res Ctr, Granada 18016, Spain, [Dieguez, Estefania] Univ Granada, EURISTIKOS Excellence Ctr Paediat Res, Biomed Res Ctr, Granada 18016, Spain, [Garcia-Ricobaraza, Maria] Univ Granada, EURISTIKOS Excellence Ctr Paediat Res, Biomed Res Ctr, Granada 18016, Spain, [Garcia-Santos, Jose Antonio] Univ Granada, EURISTIKOS Excellence Ctr Paediat Res, Biomed Res Ctr, Granada 18016, Spain, [Bermudez, Mercedes G.] Univ Granada, EURISTIKOS Excellence Ctr Paediat Res, Biomed Res Ctr, Granada 18016, Spain, [Campoy, Cristina] Univ Granada, EURISTIKOS Excellence Ctr Paediat Res, Biomed Res Ctr, Granada 18016, Spain, [Nieto-Ruiz, Ana] Univ Granada, Mind Brain & Behav Res Ctr CIMCYC, Granada 18011, Spain, [Sepulveda-Valbuena, Natalia] Pontificia Univ Javeriana, Fac Sci, Nutr & Biochem Dept, Bogota 110231, Colombia, [Miranda, M. Teresa] Univ Granada, Sch Med, Dept Biostat, Granada 18016, Spain, [Jimenez, Jesus] Labs Ordesa SL, Barcelona 08820, Spain, [De-Castellar, Roser] Labs Ordesa SL, Barcelona 08820, Spain, [Campoy, Cristina] Inst Hlth Carlos III, Granadas Node, Spanish Network Biomed Res Epidemiol & Publ Hlth, Madrid, Spain, Laboratorios Ordesa, S.L., and COGNIS-team
- Subjects
Risk ,Diarrhea ,0301 basic medicine ,medicine.medical_specialty ,Efficacy ,Synbiotics ,Breastfeeding ,Medicine (miscellaneous) ,Care ,Early nutrition ,03 medical and health sciences ,chemistry.chemical_compound ,0404 agricultural biotechnology ,Standard infant formula ,Milk fat globule membrane ,Internal medicine ,medicine ,TX341-641 ,Prebiotic oligosaccharides ,Milk fat globule membran ,chemistry.chemical_classification ,030109 nutrition & dietetics ,Nutrition and Dietetics ,Respiratory tract infections ,Nutrition. Foods and food supply ,business.industry ,Probiotics ,Prevention ,Incidence (epidemiology) ,Double-blind ,04 agricultural and veterinary sciences ,040401 food science ,Sialic acid ,Endocrinology ,chemistry ,Infant formula ,Respiratory-tract infections ,Safety ,Infection ,business ,Food Science ,Polyunsaturated fatty acid - Abstract
Special thanks to all the parents who collaborated and granted their confidence upon the EURISTIKOS Excellence Centre for Paediatric Research, University of Granada, the children for their patience and their smiles. Thanks to all the collaborators of the COGNIS-team, and Laboratorios Ordesa, S.L. for funding support., Functional nutrients like synbiotics or milk-fat globule membrane (MFGM) affect positively host immunity, modifying intestinal microbioma and reducing early childhood infections. We compared effects of an experimental enriched-infant formula with long chain polyunsaturated fatty acids, MFGM, synbiotics, sialic acid, nucleotides and gangliosides to a standard infant formula and breastfeeding regarding infections incidence and evolution in infants until 18 months of age. 170 healthy infants were enrolled in a RCT to receive either a bioactive functional nutrients enriched infant formula (EF, n = 85) or a standard formula (SF, n = 85). 50 breastfed (BF) infants were also enrolled. At age 12 months, EF group compared to SF and BF groups showed a lower incidence of infectious episodes. Moreover, they also presented less incidence of respiratory tract infections and gastrointestinal infections than SF infants, reducing risk by 30.2% and 32.5%, respectively. Infants fed with an EF seem to have reduced incidence of certain infections at 12 months of age., Laboratorios Ordesa, S.L., COGNIS-team
- Published
- 2021
89. Infant Gut Microbiota Associated with Fine Motor Skills
- Author
-
Ana López-Moreno, Alicia Ruiz, Francisco J. Torres-Espínola, Cristina Campoy, Margarita Aguilera, Tomás Cerdó, Inmaculada Acuña, Antonio Suárez, Ministerio de Educación, Cultura y Deporte (España), Ministerio de Economía y Competitividad (España), Ministerio de Ciencia e Innovación (España), Regional Government of Andalusia (España), Fundación Alfonso Martín Escudero, Unión Europea. Comisión Europea. 7 Programa Marco, and Unión Europea. Comisión Europea. H2020
- Subjects
Adult ,Male ,0301 basic medicine ,food.ingredient ,Gut–brain axis ,Neurodevelopment ,Veillonellaceae ,Physiology ,Gut flora ,Bayley Scales of Infant Development ,Article ,Coprococcus ,Feces ,03 medical and health sciences ,0302 clinical medicine ,food ,fine motricity ,RNA, Ribosomal, 16S ,microbiota ,Humans ,TX341-641 ,gut–brain axis ,Bifidobacterium ,Nutrition and Dietetics ,neurodevelopment ,Bacteria ,biology ,Nutrition. Foods and food supply ,Microbiota ,Probiotics ,Infant ,biology.organism_classification ,Parabacteroides ,Gastrointestinal Microbiome ,Breast Feeding ,030104 developmental biology ,probiotics ,Motor Skills ,Female ,Enterotype ,Roseburia ,Fine motricity ,030217 neurology & neurosurgery ,Food Science - Abstract
BACKGROUND: During early life, dynamic gut colonization and brain development co-occur with potential cross-talk mechanisms affecting behaviour. METHODS: We used 16S rRNA gene sequencing to examine the associations between gut microbiota and neurodevelopmental outcomes assessed by the Bayley Scales of Infant Development III in 71 full-term healthy infants at 18 months of age. We hypothesized that children would differ in gut microbial diversity, enterotypes obtained by Dirichlet multinomial mixture analysis and specific taxa based on their behavioural characteristics. RESULTS: In children dichotomized by behavioural trait performance in above- and below-median groups, weighted Unifrac b-diversity exhibited significant differences in fine motor (FM) activity. Dirichlet multinomial mixture modelling identified two enterotypes strongly associated with FM outcomes. When controlling for maternal pre-gestational BMI and breastfeeding for up to 3 months, the examination of signature taxa in FM groups showed that Turicibacter and Parabacteroides were highly abundant in the below-median FM group, while Collinsella, Coprococcus, Enterococcus, Fusobacterium, Holdemanella, Propionibacterium, Roseburia, Veillonella, an unassigned genus within Veillonellaceae and, interestingly, probiotic Bifidobacterium and Lactobacillus were more abundant in the above-median FM group. CONCLUSIONS: Our results suggest an association between enterotypes and specific genera with FM activity and may represent an opportunity for probiotic interventions relevant to treatment for motor disorders., Spanish Ministry of Innovation and Science, Junta de Andalucía: Excellence Projects (P06-CTS-02341), Spanish Ministry of Economy and Competitiveness (BFU2012-40254-C03-02) and partially funded by the European Commission MyNewGut FP7 EU Project (Grant agreement n◦ 613979), MyNewGut FP7 EU Project (Grant agreement n◦ 613979), DynaHEALTH EU Project HORIZON 2020 (Grant agreement n◦ : 633595-2), Marie Curie post-doctoral fellowship (FP7, no. 329812, NutriOmics), Spanish Ministry of Education, Culture and Sports (FPU16/04587)
- Published
- 2021
90. Maternal BMI and gestational diabetes alter placental lipid transporters and fatty acid composition
- Author
-
Hans Demmelmair, Stefan Dehmel, Maria Carmen Padilla, Berthold Koletzko, Maria Teresa Segura, Petra Nathan, Ricardo Rueda, Cristina Campoy, and Susanne Krauss-Etschmann
- Subjects
Adult ,0301 basic medicine ,Endothelial lipase ,medicine.medical_specialty ,Placenta ,CD36 ,030209 endocrinology & metabolism ,Body Mass Index ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Internal medicine ,medicine ,Humans ,Obesity ,chemistry.chemical_classification ,Fetus ,Lipoprotein lipase ,biology ,Fatty Acids ,nutritional and metabolic diseases ,Obstetrics and Gynecology ,Fatty acid ,Metabolism ,FABP7 ,Fatty Acid Transport Proteins ,Lipid Metabolism ,medicine.disease ,Gestational diabetes ,Diabetes, Gestational ,030104 developmental biology ,Endocrinology ,Reproductive Medicine ,chemistry ,Case-Control Studies ,biology.protein ,Female ,Developmental Biology - Abstract
Introduction: Placental fatty acid (FA) uptake and metabolism depend on maternal supply which may be altered when women have a high pre-pregnancy body mass index (BMI) or develop gestational diabetes (GDM). Consequently, an impaired FA transport to the fetus may negatively affect fetal development. While placental adaptation of maternal-fetal glucose transfer in mild GDM has been described, knowledge on placental FA acid metabolism and possible adaptations in response to maternal obesity or GDM is lacking. We aimed to analyze the FA composition and the expression of key genes involved in FA uptake and metabolism in placentas from women with pre-pregnancy normal weight (18.5 = 30 kg/m(2)), and lean pregnant women with GDM. Methods: Placental FA content was determined by gas liquid chromatography. Placental mRNA expression of FA transport proteins (FATPI, FATP4, FATP6), FA binding proteins (FABP3, FABP4, FABP7), FA translocase (FAT/CD36) and enzymes (Endothelial lipase (EL) and lipoprotein lipase (LPL)) were quantified by qRT-PCR. Results: High pre-pregnancy BMI and GDM were associated with decreased placental FATP1, FATP4, EL and increased FAT/CD36 and FATP6 expressions. LPL mRNA levels and placental total FA content were similar among groups. Specific FA, including some long-chain polyunsaturated FA, were altered. Discussion: Our results demonstrate that high pre-pregnancy BMI or GDM independently alter mRNA expression levels of genes involved in FA uptake and metabolism and the placental FA profile, which could affect fetal development and long-term health. (C) 2017 Published by Elsevier Ltd.
- Published
- 2017
91. Maternal obesity is associated with gut microbial metabolic potential in offspring during infancy
- Author
-
Hatim Azaryah, Francisco J. Torres-Espínola, Alicia Ruiz, M. Teresa Segura, Tomás Cerdó, Cristina Campoy, Luz García-Valdés, Antonio Suárez, and Ruy Jauregui
- Subjects
Adult ,Male ,0301 basic medicine ,Physiology ,Offspring ,Firmicutes ,Biology ,Gut flora ,Biochemistry ,Body Mass Index ,Cohort Studies ,Fetal Development ,Feces ,03 medical and health sciences ,Pregnancy ,medicine ,Humans ,Obesity ,Microbiome ,Phylogeny ,2. Zero hunger ,Genetics ,Bacteroidetes ,Gastrointestinal Microbiome ,Infant ,Reproducibility of Results ,Maternal Nutritional Physiological Phenomena ,General Medicine ,biology.organism_classification ,medicine.disease ,Molecular Typing ,Pregnancy Complications ,030104 developmental biology ,Spain ,Fermentation ,Dysbiosis ,Female ,Body mass index - Abstract
Children born to obese mothers are at increased risk for obesity, but the mechanisms behind this association are not fully understood. Our study aimed to investigate differences in the functions encoded by the microbiome of infants at 18 months of age when the transition from early infant-feeding to solid family foods is established. To investigate the impact of maternal prepregnancy body mass index on infants’ gut microbiome, faecal samples from infants born to normoweight (n = 21) and obese mothers (n = 18) were analysed by 16S rRNA gene sequencing and a functional-inference-based microbiome analysis. Our results indicated that Firmicutes was significantly enriched in infants born to normoweight mothers whereas Bacteroidetes was significantly enriched in infants born to obese women. In both microbiomes, the greatest number of genes (>50%) that were assigned a function encoded for proteins involved in “metabolism” among tier 1 KEGG Orthology (KO) categories. At lower KO functional categories, the microbiome of infants born to normoweight mothers was characterized by a significant enrichment in the abundances of “pentose phosphate pathway” (p = 0.037), “lysine biosynthesis” (p = 0.043), “glycerolipid metabolism” (p = 0.042), and “C5-branched dibasic acid metabolism” (p = 0.045). Notably, the microbiome of infants born to obese mothers was significantly enriched in “streptomycin biosynthesis” (p = 0.047), “sulphur metabolism” (p = 0.041), “taurine and hypotaurine metabolism” (p = 0.036), and “lipopolysaccharide biosynthesis” (p = 0.043). In summary, our study showed that maternal prepregnancy obesity may imprint a selective gut microbial composition during late infancy with distinct functional performances.
- Published
- 2017
92. One-year calorie restriction impacts gut microbial composition but not its metabolic performance in obese adolescents
- Author
-
Abelardo Margolles, Antonio Suárez, Cristina Campoy, Alicia Ruiz, Dietmar H. Pieper, Ruy Jauregui, Alfonso Clemente, Manuel Ferrer, Ascensión Marcos, Federico García, and Tomás Cerdó
- Subjects
0301 basic medicine ,biology ,Firmicutes ,030106 microbiology ,Calorie restriction ,Bacteroidetes ,Gut flora ,biology.organism_classification ,medicine.disease ,Microbiology ,Obesity ,03 medical and health sciences ,030104 developmental biology ,medicine ,Food science ,Bacteroides ,Roseburia ,Body mass index ,Ecology, Evolution, Behavior and Systematics - Abstract
Recent evidence has disclosed a connection between gut microbial glycosidase activity and adiposity in obese. Here, we measured microbial α-glucosidase and β-galactosidase activities and sorted fluorescently labeled β-galactosidase containing (βGAL) microorganisms in faecal samples of eight lean and thirteen obese adolescents that followed a controlled calorie restriction program during one year. β-galactosidase is a highly distributed functional trait, mainly expressed by members of Blautia, Bacteroides, Alcaligenes, Acinetobacter and Propionibacterium. Only long-term calorie restriction induced clear changes in the microbiota of obese adolescents. Long-term calorie restriction induced significant shifts in total and βGAL gut microbiota, reducing the Firmicutes:Bacteroidetes ratio and enhancing the growth of beneficial microorganisms such as Bacteroides, Roseburia, Faecalibacterium and Clostridium XIVa. Moreover, the structure and composition of βGAL community in obese after long-term calorie restriction was highly similar to that of lean adolescents. However, despite this high compositional similarity, microbial metabolic performance was different, split in two metabolic states at a body mass index value of 25. Our study shows that calorie restriction is a strong environmental force reshaping gut microbiota though its metabolic performance is linked to host's adiposity, suggesting that functional redundancy and metabolic plasticity are fundamental properties of gut microbial ecosystem.
- Published
- 2017
93. Importance of mental performance in parental choice of food for children aged 4–10 years: a study in four European countries
- Author
-
Peter Williams, Brigitte Brands, JC Lopez-Robles, Eszter Györei, Heather Gage, Tamás Decsi, Cristina Campoy, Monique M. Raats, Berthold Koletzko, and Bernadette Egan
- Subjects
Parents ,Male ,0301 basic medicine ,Gerontology ,Health Knowledge, Attitudes, Practice ,Pediatrics ,General interest ,Food choice ,Child Behavior ,Medicine (miscellaneous) ,Choice Behavior ,Cognition ,0302 clinical medicine ,Germany ,Surveys and Questionnaires ,Medicine ,Parent-Child Relations ,Young adult ,Child ,Children ,Nutrition and Dietetics ,Parenting ,Middle Aged ,Research Papers ,England ,Child, Preschool ,Female ,Diet, Healthy ,Adult ,medicine.medical_specialty ,Mental performance ,Adolescent ,Decision Making ,Nutritional Status ,030209 endocrinology & metabolism ,Food Preferences ,Young Adult ,03 medical and health sciences ,Humans ,Cognitive skill ,Hungary ,030109 nutrition & dietetics ,Health professionals ,business.industry ,Public Health, Environmental and Occupational Health ,Physical health ,European countries ,Mood ,Spain ,business - Abstract
ObjectiveTypically, attention focuses on how nutrition affects physical health. The present study investigated the importance that parents attach to the impact of diet on mental performance when choosing food for their child.DesignQuestionnaire.SettingFour European countries.SubjectsParents of children aged 4–10 years (n 1574): England (n 397), Germany (n 389), Hungary (n 398) and Spain (n 390).ResultsMost parents (80–85 %) considered the effect of food on four elements of mental performance (child’s ability to learn, attention, behaviour, mood) to be moderately, very, extremely (v. slightly, not at all) important in food choices; over 90 % considered healthiness of food and making food appealing to their child important; 79·8 % cost; 76·8 % convenience. Belief that food affects mental performance was 57·4 % (ability to learn), 60·5 % (attention); less than 40 % of parents agreed they were aware which foods had an effect. Parents with lower general interest in healthy eating were less likely to consider the effect of food on mental performance elements as important. Respondents from Germany were more likely to rate mental performance as important (except behaviour); those in Hungary less likely. The most important influence on parents’ decisions about feeding their child was their own experience, except Spain, where family/friends/health professionals were more important.ConclusionsNutrition affects brain development and cognitive functioning. Low prioritisation of the effect of food on mental performance indicates potential for educating parents.
- Published
- 2016
94. Cow’s milk allergy: towards an update of DRACMA guidelines
- Author
-
Vincenzo Fierro, Christophe Dupont, Cristina Campoy, Alessandro Fiocchi, Antonio Nieto, and Lamia Dahda
- Subjects
Pulmonary and Respiratory Medicine ,lcsh:Immunologic diseases. Allergy ,Pediatrics ,medicine.medical_specialty ,Immunology ,MEDLINE ,Breastfeeding ,Milk allergy ,Review ,DRACMA guidelines ,03 medical and health sciences ,0302 clinical medicine ,Cow's milk allergy ,030225 pediatrics ,medicine ,Immunology and Allergy ,business.industry ,Guideline ,medicine.disease ,Systematic review ,030228 respiratory system ,Cow’s milk allergy ,Pediatric allergy ,business ,lcsh:RC581-607 ,Infants - Abstract
Background In 2010, the diagnosis and treatment of IgE-mediated CMA were systematized in a GRADE guideline.Objectives & methods After 6 years, the state of the knowledge in diagnosis and treatment of CMA has largely evolved. We summarize here the main advances, and exemplify indicating some specific points: studies aimed at better knowledge of the effects of breastfeeding and the production of new special formulae intended for the treatment of CMA. The literature (PubMed/MEDLINE) was searched using the following algorithms: (1) [milk allergy] AND diagnosis; (2) [milk allergy] AND [formul*] OR [breast*], setting the search engine [6-years] time and [human] limits. The authors drew on their collective clinical experience to restrict retrieved studies to those of relevance to a pediatric allergy practice.Results Several clinical studies did address the possibility to diagnose CMA using new tools in vitro and in vivo, or to diagnose it without any evaluation of sensitization. Some studies also addressed the clinical role of formulae based on milk hydrolysates, soy, or rice hydrolysates in the treatment of CMA. Many studies have elucidated the effects of selective nutrients in breastfed infants on their immunologic and neurologic characteristics.Conclusions Evidence-based diagnostic criteria should be identified for non-IgE-mediated CMA. Debate is ongoing about the best substitute for infants with CMA. In particular, Hydrolyzed Rice Formulae have been widely assessed in the last six years. In the substitute choice, clinicians should be aware of recent studies that can modify the interpretation of the current recommendations. New systematic reviews and metanalyses are needed to confirm or modify the current DRACMA recommendations. Keywords: Cow’s milk allergy, Infants, DRACMA guidelines
- Published
- 2016
95. Role of microbiota function during early life on child's neurodevelopment
- Author
-
Alicia Ruiz, Tomás Cerdó, Antonio Suárez, Signe Altmäe, Cristina Campoy, and Luz García-Valdés
- Subjects
0301 basic medicine ,Pediatrics ,medicine.medical_specialty ,Pregnancy ,biology ,Offspring ,Brain Structure and Function ,Cognition ,Overweight ,Gut flora ,biology.organism_classification ,medicine.disease ,digestive system ,Obesity ,Developmental psychology ,03 medical and health sciences ,030104 developmental biology ,medicine ,Microbiome ,medicine.symptom ,Food Science ,Biotechnology - Abstract
Background There are critical periods during pregnancy and early life when child's neurodevelopment can be altered, where different factors including hormones, stress, genetics, and diet have an important role. Novel studies are indicating that also gut microbiota and maternal obesity can influence child's neurodevelopment. Scope and approach This review summarises the current concepts related to microbiota-gut-brain axis, including microbiota modulation of the eating behaviour, child's cognitive function and brain structure, microbiota analysis techniques and neurodevelopment assessment in children. Further, we propose and present knowledge about potential mechanisms of action and ways to intervene for disease prevention and treatments, opening up an exciting area with important medical and industrial applications. Key findings and conclusions This novel and fast developing research area is indicating that gut microbiota in association with body weight might have an important impact on foetal and child neurodevelopment. However, the exact mechanisms are not known and further research in the field is warranted. Within the MyNewGut Project we aim to analyse the impact of microbiota in association with body weight on cognitive and behaviour development in children. We will study the phylogeny and function of the gut microbial communities in overweight, obese and gestational diabetes pregnancies and in their progeny, in association with infants and children's cognitive and behavioural outcomes. As well, the impact of gut microbiome on brain structure and function during childhood will be evaluated. Results from this study will shed light on the impact of maternal and offspring gut microbiome and body weight on child's neurodevelopment, brain structure and function, and will suggest potential mechanisms for intervention.
- Published
- 2016
96. The Effect of Maternal Obesity on Breast Milk Fatty Acids and Its Association with Infant Growth and Cognition—The PREOBE Follow-Up
- Author
-
Maria Teresa Segura, Luz García-Valdés, Andrea de la Garza Puentes, Francisco J. Torres-Espínola, Cristina Campoy, Rosa María Montes Goyanes, Ana I. Castellote, Adrià Martí Alemany, M. Carmen López-Sabater, Aida Maribel Chisaguano, Mireia Escudero-Marín, Universidade de Santiago de Compostela. Instituto de Investigación e Análises Alimentarias, and Universidade de Santiago de Compostela. Departamento de Química Analítica, Nutrición e Bromatoloxía
- Subjects
0301 basic medicine ,cognition ,breastfeeding ,Breastfeeding ,Early life nutrition ,Growth ,Overweight ,Body Mass Index ,Child Development ,0302 clinical medicine ,Cognition ,Pregnancy ,Medicine ,030212 general & internal medicine ,Children ,Child development ,Omega-6 ,Omega-3 ,2. Zero hunger ,chemistry.chemical_classification ,Nutrition and Dietetics ,food and beverages ,3. Good health ,maternal obesity ,DHA ,colostrum ,Docosahexaenoic acid ,Child, Preschool ,Prenatal Exposure Delayed Effects ,Cognició ,Programming ,early life nutrition ,Obesitat ,breast milk ,Female ,medicine.symptom ,omega-3 ,Creixement ,lcsh:Nutrition. Foods and food supply ,Mature milk ,Polyunsaturated fatty acid ,medicine.medical_specialty ,Breast milk ,omega-6 ,growth ,lcsh:TX341-641 ,Àcids grassos omega-3 ,fatty acids ,LC-PUFA ,programming ,Article ,03 medical and health sciences ,children ,Maternal obesity ,Internal medicine ,Omega-3 fatty acids ,Humans ,Obesity ,Fatty acids ,mature milk ,030109 nutrition & dietetics ,Milk, Human ,business.industry ,Colostrum ,Infant, Newborn ,Infant ,Maternal Nutritional Physiological Phenomena ,medicine.disease ,AA ,Pregnancy Complications ,Desenvolupament infantil ,Endocrinology ,chemistry ,Llet materna ,business ,Body mass index ,Follow-Up Studies ,Food Science - Abstract
This study analyzed how maternal obesity affected fatty acids (FAs) in breast milk and their association with infant growth and cognition to raise awareness about the programming effect of maternal health and to promote a healthy prenatal weight. Mother&ndash, child pairs (n = 78) were grouped per maternal pre-pregnancy body mass index (BMI): normal-weight (BMI = 18.5&ndash, 24.99), overweight (BMI = 25&ndash, 29.99) and obese (BMI >, 30). Colostrum and mature milk FAs were determined. Infant anthropometry at 6, 18 and 36 months of age and cognition at 18 were analyzed. Mature milk exhibited lower arachidonic acid (AA) and docosahexaenoic acid (DHA), among others, than colostrum. Breast milk of non-normal weight mothers presented increased saturated FAs and n6:n3 ratio and decreased &alpha, linolenic acid (ALA), DHA and monounsaturated FAs. Infant BMI-for-age at 6 months of age was inversely associated with colostrum n6 (e.g., AA) and n3 (e.g., DHA) FAs and positively associated with n6:n3 ratio. Depending on the maternal weight, infant cognition was positively influenced by breast milk linoleic acid, n6 PUFAs, ALA, DHA and n3 LC-PUFAs, and negatively affected by n6:n3 ratio. In conclusion, this study shows that maternal pre-pregnancy BMI can influence breast milk FAs and infant growth and cognition, endorsing the importance of a healthy weight in future generations.
- Published
- 2019
- Full Text
- View/download PDF
97. Early nutrition and gut microbiome: interrelationship between bacterial metabolism, immune system, brain structure, and neurodevelopment
- Author
-
Tomás Cerdó, Estefanía Diéguez, and Cristina Campoy
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Physiology ,Endocrinology, Diabetes and Metabolism ,Microbial metabolism ,Infant health ,Gut flora ,digestive system ,Nervous System ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Physiology (medical) ,Internal medicine ,medicine ,Animals ,Humans ,Colonization ,Pregnancy ,biology ,Bacteria ,Brain ,biology.organism_classification ,medicine.disease ,Gut microbiome ,Early life ,Gastrointestinal Microbiome ,030104 developmental biology ,Endocrinology ,Liver ,Immune System ,030217 neurology & neurosurgery - Abstract
Disturbances of diet during pregnancy and early postnatal life may impact colonization of gut microbiota during early life, which could influence infant health, leading to potential long-lasting consequences later in life. This is a nonsystematic review that explores the recent scientific literature to provide a general perspective of this broad topic. Several studies have shown that gut microbiota composition is related to changes in metabolism, energy balance, and immune system disturbances through interaction between microbiota metabolites and host receptors by the gut-brain axis. Moreover, recent clinical studies suggest that an intestinal dysbiosis in gut microbiota may result in cognitive disorders and behavioral problems. Furthermore, recent research in the field of brain imaging focused on the study of the relationship between gut microbial ecology and large-scale brain networks, which will help to decipher the influence of the microbiome on brain function and potentially will serve to identify multiple mediators of the gut-brain axis. Thus, knowledge about optimal nutrition by modulating gut microbiota-brain axis activity will allow a better understanding of the molecular mechanisms involved in the crosstalk between gut microbiota and the developing brain during critical windows. In addition, this knowledge will open new avenues for developing novel microbiota-modulating based diet interventions during pregnancy and early life to prevent metabolic disorders, as well as neurodevelopmental deficits and brain functional disorders.
- Published
- 2019
98. Should formula for infants provide arachidonic acid along with DHA? A position paper of the European Academy of Paediatrics and the Child Health Foundation
- Author
-
Mandy Daly, Ines Gonzalez-Casanova, Adamos Hadjipanayis, Nataša FidlerMis, M. Tom Clandinin, Susan E. Carlson, Conny Tanjung, Cristina Campoy, Philip C. Calder, Usha Ramakrishan, Patrick Tounian, Silke Mader, K. Bergmann, Tamás Decsi, J. Thomas Brenna, Camilia R. Martin, Sean Strain, Valerie Matthäus, Magnus Domellöf, John Colombo, Johannes B. van Goudoever, Hans Demmelmair, Alexandre Lapillonne, Berthold Koletzko, Cornelius M. Smuts, Olle Hernell, 20924445 - Smuts, Cornelius Mattheus, Neonatology, AGEM - Digestive immunity, AGEM - Endocrinology, metabolism and nutrition, ARD - Amsterdam Reproduction and Development, Pediatric surgery, ACS - Diabetes & metabolism, and Amsterdam Reproduction & Development (AR&D)
- Subjects
Long-chain PUFAs ,breast milk substitutes ,Docosahexaenoic Acids ,Medicine (miscellaneous) ,Pediatrics ,Child health ,Infant nutrition ,Food safety ,chemistry.chemical_compound ,Child Development ,Breast milk substitutes ,Environmental health ,media_common.cataloged_instance ,Medicine ,Humans ,European Union ,European union ,media_common ,Nutrition and Dietetics ,Arachidonic Acid ,infant nutrition ,business.industry ,long-chain PUFAs ,Fatty Acids ,Child Health ,food and beverages ,Infant ,Infant Formula ,food safety ,European Commission Formula Delegated Act 2016/127 ,Infant formula ,chemistry ,Arachidonic acid ,Food Additives ,business - Abstract
Recently adopted regulatory standards on infant and follow-on formula for the European Union stipulate that from February 2020 onwards, all such products marketed in the European Union must contain 20-50 mg omega-3 DHA (22:6n-3) per 100 kcal, which is equivalent to about 0.5-1% of fatty acids (FAs) and thus higher than typically found in human milk and current infant formula products, without the need to also include ω-6 arachidonic acid (AA; 20:4n-6). This novel concept of infant formula composition has given rise to concern and controversy because there is no accountable evidence on its suitability and safety in healthy infants. Therefore, international experts in the field of infant nutrition were invited to review the state of scientific research on DHA and AA, and to discuss the questions arising from the new European regulatory standards. Based on the available information, we recommend that infant and follow-on formula should provide both DHA and AA. The DHA should equal at least the mean content in human milk globally (0.3% of FAs) but preferably reach 0.5% of FAs. Although optimal AA intake amounts remain to be defined, we strongly recommend that AA should be provided along with DHA. At amounts of DHA in infant formula up to ∼0.64%, AA contents should at least equal the DHA contents. Further well-designed clinical studies should evaluate the optimal intakes of DHA and AA in infants at different ages based on relevant outcomes.
- Published
- 2019
99. A systematic review of the effects of increasing arachidonic acid intake on PUFA status, metabolism and health-related outcomes in humans
- Author
-
Ans Eilander, Bert J. M. van de Heijning, Szimonetta Lohner, Cristina Campoy, Per-Olof Larsson, Stewart Forsyth, Aliz Szommer, Mathilde Fleith, Ronald P. Mensink, Bettina Schelkle, and Philip C. Calder
- Subjects
0301 basic medicine ,Male ,BLOOD ,Medicine (miscellaneous) ,Physiology ,Blood lipids ,ARA arachidonic acid ,law.invention ,chemistry.chemical_compound ,Randomized controlled trial ,LC-PUFA long-chain PUFA ,law ,Medicine ,DGLA dihomo-γ-linolenic acid ,heterocyclic compounds ,RESISTANCE EXERCISE ,PLATELET ,LA linoleic acid ,Randomized Controlled Trials as Topic ,POLYUNSATURATED FATTY-ACIDS ,chemistry.chemical_classification ,FA fatty acid ,Nutrition and Dietetics ,Arachidonic Acid ,n-6 Fatty acids ,PL phospholipid ,food and beverages ,RCT randomised controlled trial ,CE cholesteryl ester ,Middle Aged ,Arachidonic acid ,Fatty Acids, Unsaturated ,Female ,lipids (amino acids, peptides, and proteins) ,DIETARY SUPPLEMENTATION ,Polyunsaturated fatty acid ,Adult ,LONG-CHAIN N-3 ,EICOSANOIDS ,Linoleic acid ,Nutritional Status ,03 medical and health sciences ,Humans ,CELL ,Fatty acids ,Adverse effect ,Aged ,Inflammation ,030109 nutrition & dietetics ,Dihomo-γ-linolenic acid ,business.industry ,Human health ,Fatty acid ,DOCOSAHEXAENOIC ACID ,biochemical phenomena, metabolism, and nutrition ,carbohydrates (lipids) ,030104 developmental biology ,chemistry ,Dietary Supplements ,business - Abstract
We conducted a systematic review of randomised controlled trials (RCT) of increased intake of arachidonic acid (ARA) on fatty acid status and health outcomes in humans. We identified twenty-two articles from fourteen RCT. Most studies were conducted in adults. These used between 80 and 2000 mg ARA per d and were of 1–12 weeks duration. Supplementation with ARA doses as low as 80 mg/d increased the content of ARA in different blood fractions. Overall there seem to be few marked benefits for adults of increasing ARA intake from the typical usual intake of 100–200 mg/d to as much as 1000 mg/d; the few studies using higher doses (1500 or 2000 mg/d) also report little benefit. However, there may be an impact of ARA on cognitive and muscle function which could be particularly relevant in the ageing population. The studies reviewed here suggest no adverse effects in adults of increased ARA intake up to at least 1000–1500 mg/d on blood lipids, platelet aggregation and blood clotting, immune function, inflammation or urinary excretion of ARA metabolites. However, in many areas there are insufficient studies to make firm conclusions, and higher intakes of ARA are deserving of further study. Based on the RCT reviewed, there are not enough data to make any recommendations for specific health effects of ARA intake.
- Published
- 2019
100. Diet quality index as a predictor of treatment efficacy in overweight and obese adolescents: The EVASYON study
- Author
-
Luis A. Moreno, Belén Zapatera, Manuel Lorenzo Delgado, Ahmad Agil, María E. Calle, A. Fernández-Mayorga, Santiago Navas-Carretero, T. Pozo, Miguel Martín-Matillas, J. Fernández, J A Martínez, M. Pérez-Expósito, Julia Wärnberg, Jose A. Martín-Lagos, R. Sanz, C. Muro, A. Villaseñor, Miguel García-Fuentes, David Martínez-Gómez, Javier Romeo, Pablo Tercedor, Danilo R. Silva, C. Pérez-Ballesteros, Óscar L. Veiga, M.G. Miranda, A.M. Pérez-Granados, Ascensión Marcos, Amelia A. Martí del Moral, A. Moleres, Domingo González-Lamuño, M.P. Vaquero, Germán Vicente-Rodríguez, P. Romero, T. Rendo, Gloria Bueno, J. M. Garagorri, María José Cuesta Aguilar, P. Rey, Gerardo Rodríguez, Pilar De Miguel-Etayo, Carlos Redondo-Figuero, Esther Nova, M.J. Piqueras, Amelia Marti, Javier Santabárbara, P. DeRufino, Teresa Amigo, E Martin-Bautista, Gemma López-Belmonte, Cristina Campoy, Virginia A. Aparicio, A. Carbonell, M. Garófano, Sonia Gómez-Martínez, Palma Chillón, R. Muñoz, María José Aradilla Marqués, D. Madruga, Ariel Villagra, Gonzalo Morandé, C. Azcona-SanJulian, Maria Cristina Azcona-San Julian, L. Barrios, Concepción Tomás, Ma.I. Mesana, M. A. Puertollano, P. Sánchez, E.L. Díaz, Instituto de Salud Carlos III, Ministerio de Sanidad, Consumo y Bienestar Social (España), Ministerio de Asuntos Exteriores y Cooperación (España), Diputación General de Aragón, and European Commission
- Subjects
0301 basic medicine ,Male ,medicine.medical_specialty ,Pediatric Obesity ,Index (economics) ,Adolescent ,Family support ,Multi-intervention approach ,030209 endocrinology & metabolism ,Overweight ,Adolescents ,Critical Care and Intensive Care Medicine ,Dietary compliance ,03 medical and health sciences ,0302 clinical medicine ,Intensive Phase ,Intervention (counseling) ,Weight Loss ,medicine ,Humans ,Meal ,030109 nutrition & dietetics ,Nutrition and Dietetics ,business.industry ,Diet quality index ,Treatment efficacy ,Diet ,Weight Reduction Programs ,Diet quality ,Spain ,Physical therapy ,Patient Compliance ,Fat mass loss ,Female ,medicine.symptom ,business ,Nutritive Value - Abstract
The EVASYON Study Group., [Background & aim]: A diet quality index (DQI) is a tool that provides an overall score of an individual's dietary intake when assessing compliance with food-based dietary guidelines. A number of DQIs have emerged, albeit their associations with health-related outcomes are debated. The aim of the present study was to assess whether adherence to dietary intervention, and the overall quality of the diet, can predict body composition changes., [Methods]: To this purpose, overweight/obese adolescents (n = 117, aged: 13–16 years; 51 males, 66 females) were recruited into a multi-component (diet, physical activity and psychological support) family-based group treatment programme. We measured the adolescents' compliance and body composition at baseline and after 2 months (intensive phase) and 13 months (extensive phase) of follow-up. Also, at baseline, after 6 months, and at the end of follow-up we calculated the DQI., [Results]: Global compliance with the dietary intervention was 37.4% during the intensive phase, and 14.3% during the extensive phase. Physical activity compliance was 94.1% at 2-months and 34.7% at 13months and psychological support compliance were growing over the intervention period (10.3% intensive phase and 45.3% during extensive phase). Adolescents complying with the meal frequency criteria at the end of the extensive phase had greater reductions in FMI z-scores than those did not complying (Cohen's d = 0.53). A statistically significant association was observed with the diet quality index. DQI-A variation explained 98.1% of BMI z-score changes and 95.1% of FMI changes., [Conclusions]: We conclude that assessment of changes in diet quality could be a useful tool in predicting body composition changes in obese adolescents involved in a diet and physical activity intervention programme backed-up by psychological and family support., The study was supported by the Ministry of Health, Social Services and Equality via the Carlos III Institute of Health (FIS Grant PI051080, PI051579). The EVASYON study received the award for the best applied research project in 2009 from AESAN (Spanish Agency for Food Safety and Nutrition from the Spanish Ministry of Health and Consumer Affairs. The study was supported by Aragon's Regional Government (DGA, Diputación General de Aragón) and European Regional Development Fund.
- Published
- 2019
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.