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Effects of Maternal Fish Oil and/or 5-Methyl-Tetrahydrofolate Supplementation during Pregnancy on Offspring Brain Resting-State at 10 Years Old: A Follow-Up Study from the NUHEAL Randomized Controlled Trial
- Source :
- Nutrients, Volume 12, Issue 9, Nutrients, Vol 12, Iss 2701, p 2701 (2020), Digibug: Repositorio Institucional de la Universidad de Granada, Universidad de Granada (UGR), Digibug. Repositorio Institucional de la Universidad de Granada, instname
- Publication Year :
- 2020
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2020.
-
Abstract
- Recent studies have shown that maternal supplementation with folate and long-chain polyunsaturated fatty acids (LC-PUFAs) during pregnancy may affect children&rsquo<br />s brain development. We aimed at examining the potential long-term effect of maternal supplementation with fish oil (FO) and/or 5-methyl-tetrahydrofolate (5-MTHF) on the brain functionality of offspring at the age of 9.5&ndash<br />10 years. The current study was conducted as a follow-up of the Spanish participants belonging to the Nutraceuticals for a Healthier Life (NUHEAL) project<br />57 children were divided into groups according to mother&rsquo<br />s supplementation and assessed through functional magnetic resonance imaging (fMRI) scanning and neurodevelopment testing. Independent component analysis and double regression methods were implemented to investigate plausible associations. Children born to mothers supplemented with FO (FO and FO + 5-MTHF groups, n = 33) showed weaker functional connectivity in the default mode (DM) (angular gyrus), the sensorimotor (SM) (motor and somatosensory cortices) and the fronto-parietal (FP) (angular gyrus) networks compared to the No-FO group (placebo and 5-MTHF groups, n = 24) (PFWE &lt<br />0.05). Furthermore, no differences were found regarding the neuropsychological tests, except for a trend of better results in an object recall (memory) test. Considering the No-FO group, the aforementioned networks were associated negatively with attention and speed-processing functions. Mother&rsquo<br />s FO supplementation during pregnancy seems to be able to shape resting-state network functioning in their children at school age and appears to produce long-term effects on children&acute<br />s cognitive processing.
- Subjects :
- Male
0301 basic medicine
Fish oils
Folate
Neurodevelopment
Physiology
Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Magnetic Resonance Imaging [Medical Subject Headings]
Brain function
Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Principal Component Analysis [Medical Subject Headings]
fish oil
law.invention
Resting-state functional neuroimaging
Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]
Child Development
0302 clinical medicine
Randomized controlled trial
law
Pregnancy
Aceites de pescado
Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure::Maternal Exposure [Medical Subject Headings]
Child
Children
Tetrahydrofolates
Default mode network
Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy [Medical Subject Headings]
Principal Component Analysis
Nutrition and Dietetics
Maternal nutritional physiological phenomena
Fenómenos fisiologicos nutricionales maternos
neurodevelopment
Neuropsychology
Brain
Magnetic Resonance Imaging
3. Good health
Maternal Exposure
Niño
Technology and Food and Beverages::Food and Beverages::Food::Dietary Supplements [Medical Subject Headings]
Regression Analysis
Female
Ácido fólico
pregnancy
lcsh:Nutrition. Foods and food supply
Adult
Anthropology, Education, Sociology and Social Phenomena::Human Activities::Leisure Activities::Relaxation::Rest [Medical Subject Headings]
Anatomy::Nervous System::Nerve Net [Medical Subject Headings]
Offspring
Embarazo
Phenomena and Processes::Physiological Phenomena::Physiological Processes::Growth and Development::Human Development::Child Development [Medical Subject Headings]
Rest
Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Pteridines::Pterins::Folic Acid::Tetrahydrofolates [Medical Subject Headings]
Check Tags::Male [Medical Subject Headings]
lcsh:TX341-641
Fish oil
Placebo
folate
Article
Angular gyrus
brain function
03 medical and health sciences
Fish Oils
children
Chemicals and Drugs::Lipids::Oils::Fish Oils [Medical Subject Headings]
Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up Studies [Medical Subject Headings]
medicine
Humans
Persons::Persons::Age Groups::Child [Medical Subject Headings]
Persons::Persons::Age Groups::Adult [Medical Subject Headings]
Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Regression Analysis [Medical Subject Headings]
030109 nutrition & dietetics
Resting state fMRI
Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Maternal Nutritional Physiological Phenomena [Medical Subject Headings]
business.industry
resting-state functional neuroimaging
Maternal Nutritional Physiological Phenomena
Anatomy::Nervous System::Central Nervous System::Brain [Medical Subject Headings]
medicine.disease
Check Tags::Female [Medical Subject Headings]
Dietary Supplements
Nerve Net
business
030217 neurology & neurosurgery
Follow-Up Studies
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....ae7291bc14c376efb7b8e82e25873287
- Full Text :
- https://doi.org/10.3390/nu12092701