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57. Complications of pulmonary vein isolation in atrial fibrillation: predictors and comparison between four different ablation techniques: Results from the MIddelheim PVI-registry.

Author

Greef, Yves De, Ströker, Edwin, Schwagten, Bruno, Kupics, Kaspars, Cocker, Jeroen De, Chierchia, Gian-Battista, Asmundis, Carlo de, Stockman, Dirk, Buysschaert, Ian, De Greef, Yves, Ströker, Edwin, De Cocker, Jeroen, and de Asmundis, Carlo

Subjects
ATRIAL fibrillation diagnosis, TREATMENT of surgical complications, ATRIAL fibrillation, CATHETER ablation, COMPARATIVE studies, CRYOSURGERY, ELECTRODES, RESEARCH methodology, MEDICAL cooperation, PULMONARY veins, RESEARCH, RISK assessment, SEX distribution, SURGICAL complications, TIME, COMORBIDITY, PRODUCT design, EVALUATION research, TREATMENT effectiveness, ACQUISITION of data, DISEASE prevalence, PATIENT selection, VASCULAR catheters
Abstract

Aims: To define predictors of complications of pulmonary vein isolation (PVI) and compare safety between different ablation techniques.Methods and results: One thousand patients with atrial fibrillation (AF) (age 60 ± 10, 72% males, CHA2DS2-VASc score 1 ± 1) underwent PVI using various techniques: conventional PVI (CPVI) using mapping with irrigated point-per-point RF ablation (n = 576), multi-electrode RF ablation with the pulmonary vein ablation catheter (PVAC) (n = 272) or high density mesh ablator (HDMA) (n = 59) and cryoballoon (CB) ablation (n = 93). A complication was defined as any procedure-related adverse event resulting in permanent injury or death, requiring intervention or treatment, or prolonging/requiring hospitalization for >48 h. A total of 105 (10.5%) complications occurred in 101 (10.1%) patients. No periprocedural death occurred. Most frequent complications were vascular complications (4%) and pericarditis (3.1%). Seven patients experienced permanent deficit due to PV stenosis (n = 3, 1 CPVI, 2 PVAC) (n = 3) and phrenic nerve palsy (PNP) (n = 4, 3 CPVI, 1 PVAC). Independent predictors of complications were female sex [odds ratio (OR) = 1.73; 95% confidence interval (CI) 1.08-2.79; P = 0.023], CHA2DS2-VASc score (OR = 1.24; 95% CI 1.01-1.52; P = 0.039), and ablation technique (P = 0.006) in multivariable-adjusted analysis. Among the different techniques, CB (P = 0.047) and PVAC ablation (P = 0.003) had lowest overall complication rates. Complication profile (type/severity) differed between techniques (association between CB and PNP, CPVI and pericardial injury, PVAC and transient ischaemic attack/PV stenosis).Conclusion: Overall complication rate of PVI with various techniques is 10.5%. Permanent deficit occurred only after PVAC and CPVI in 0.7% of patients. Female sex and a higher CHA2DS2-VASc score increase, while PVAC and CB-PVI decrease, overall risk. Differences in overall safety and individual complication profile make selection of the ablation technique in relation to clinical risk profile possible. [ABSTRACT FROM AUTHOR]

Published
2018
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58. Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI): a phase 3, placebo-controlled, randomised trial

Author

Bhatt, Deepak L, Steg, Philippe Gabriel, Mehta, Shamir R, Leiter, Lawrence A, Simon, Tabassome, Fox, Kim, Held, Claes, Andersson, Marielle, Himmelmann, Anders, Ridderstråle, Wilhelm, Chen, Jersey, Song, Yang, Diaz, Rafael, Goto, Shinya, James, Stefan K, Ray, Kausik K, Parkhomenko, Alexander N, Kosiborod, Mikhail N, McGuire, Darren K, Harrington, Robert A, Santos, Vladimir, Jain, Ashit, Lendel, Irina, Russo, Michael, Haught, W H, Bouza, Manuel, Gogia, Harinder, Banerjee, Supratim, Kichura, George, Kantaros, Louis, Padron, Francisco, Passi, Rakesh, Stone, Jay, Pursley, Michael, D'Urso, Michael, Gardner, Timothy, Bennett, James, Nour, Khaled, Saini, Satinder, Zhang, Wenwu, Kumbhani, Dharam, Thomas, Dustin, Angiolillo, Dominick, Bertolet, Barry, Roman-Miranda, Amaury, Black, Robert, Manshadi, Ramin, Vaca, Carlos, Blanco, Antonio, Napoli, Mark, Brabham, David, Akyea-Djamson, Ayim, Desai, Pratik, Prasada, Sudhir, Khaira, Ajit, Forgosh, Leslie, Lieber, Ira, Umpierrez, Guillermo, Singal, Dinesh, Londono, Juan, Fraser, Neil, Ruiz, Jose, Vega, Damaris, Rodriguez, Lilia, Brown, Christopher, Syed, Faizullah, Aggarwala, Guarav, Eaves, William, Foster, Michael, Gupta, Dinesh, Avino, David, Asfour, Wail, Tonnessen, Glen, Zhao, Xue-Qiao, Singh, Narendra, Brockmyre, Andrew, Lepor, Norman, Shammas, Nicolas, Blick, David, Hearne, Steven, Prodafikas, John, Carell, Edgar, Izzo, Mark, Karim, Amin, Zakhary, Bosh, Atieh, Mahmoud, Leichter, Steven, Meadows, Charles, Hotchkiss, David, Abu-Fadel, Mazen, Wiseman, Alan, Bander, Jeffrey, Shah, Mahesh, Banerjee, Subhash, Ganim, Ricky, Sopko, Karen, Khan, Misal, Lloret, Ramon, Weirick, Troy, Mehta, Rajendra, Thadani, Udho, Bhargava, Anuj, Kosiborod, Mikhail, Moya, Jaynier, Staniloae, Cezar, Guerra, Yamirka D, Chhabra, Anil, Kosmicki, Douglas, Shaheen, Wassim, Mohammed, Akber, Bitters, J'Cinda, Pattanayak, Jan, Javier, Julian, Srivastava, Sunny, Phillips, Roland, Al-Amin, Jessie, Lillestol, Michael, Simpson, Patrick, Hazan, Lydie, Amin, Amit, Shah, Gopi, Korpas, Denes, Platt, Bruce, Dickert, Jim, Puente, Orlando, Hiotis, Louis, Doyle, Timothy, Rajan, Raj, Meholick, Alan, Gring, Christian, Hage-Korban, Elie, Feldman, Robert, Colfer, Harry, Butman, Samuel, Foster, Malcolm, Hart, Terence, Huling, Randall, Eshaghian, Shervin, Quintana, Ofsman, Cheung, Deanna, Handel, Franklin, Rodriguez, Mara, Suh, David, Gordon, Paul, Pressman, Gregg, Bauer, Michael, French, William, Barettella, Mark, Chatrathi, Sridhar, Suresh, Damodhar, Goldberg, Ronald, Huth, Mark, Younis, Liwa, Rahman, Aref, Mascolo, Richard, Welch, Michelle, Suneja, Randeep, Smith, Stephen, Shurmur, Scott, Agaiby, John, Jingo, Ahmad, Johnston, Janice, Beth, Mary, Vlastaris, Anthony, Kemp, Susan, Taheri, Hamid, Pereira, Edward, Deyoung, Michael, Hawa, Zafir, Smith, Ray, Galski, Thomas, Garas, Samer, Reddy, M, Sharma, Susheel, Hargrove, Joeseph, Treasure, Charles, Emerson, Ronald, Haddad, Tariq, Rohr, Kathryn, Levinson, Larry, Gaona, Raul, Uretsky, Barry, Maheshwari, Hiralal, Lee, Denny, Kinnaman, Stephanie, Singal, Robert, Geohas, Jeffrey, Gigliotti, Osvaldo, Raisinghani, Ajit, Khurana, Charanjit, Hella, Brent, Kelberman, Michael, Voyce, Steven, Singh, Sanjay, Lo, Eric, Singh, Pradeep, Goodfellow, Ross, Fischer, Stuart, Lorraine, Richard, Turner, Traci, Shanes, Jeffrey, Busch, Robert, Broker, Robert, Zaniewski, Michelle, Pounds, Kevin, Debs-Perez, Giselle, Ong, Stephen, Frandsen, Brad, Fullington, Douglas, Jaffrani, Naseem, Khan, Ahtaram, Lee, Marcus, Pouzar, Joe, Revtyak, George, Gonzalez, Julian, Nakhle, Samer, Murillo, Abel, Young, Douglas, Makam, Sashi, Syed, Mushtaq, Woolf, Kevin, Grena, Paul, Alfata, Sarab, Mahal, Sharan, Hoffman, David, Kizhakekuttu, Tinoy, Deering, Joseph, Bhavsar, Janak, Mikesell, Scott, Wilson, William, Wilson, Vance, El, Salah, Spinale, Francis, Kannarkat, Vinod, Rao, Sunder, Hanson, Lenita, Bertsch, John, Gonzalez-Ortiz, Elena, Severino, Norma, Willis, John, Schock, Joel, Bakhtari, Ladan, Gazmuri, Raul, Ansari, Saadat, Hall, Jason, Mehta, Arvind, Shealy, Neal, Zarich, Stuart, Singh, Deovrat, Vora, Kishor, Andrawis, Nabil, Molter, Darron, Maron, David, Cardona, Jose, D'Agostino, Ronald, Arshad, Tamjeed, Samaan, Rodney, Jones, David, Presser, Dale, Heath, John, Green, Sandy, Bittar, George, Henry, Sheldon, Korn, David, Schmedtje, John, Nadar, Venkatesh, Graham, Bruce, Labroo, Ajay, Clavijo, Leonardo, Roseman, Hal, Ledesma, Gilbert, Rosen, Robert, Dor, Isaac, Kirby, William, Sutton, Jennefer, Eder, Frank, Iteld, Bruce, Gomez-Cortes, Jose, Buchbinder, Maurice, Kasper, Joseph, Terrelonge, Antonio, Torres, Gustavo, Jagielo, Ted, Alvarez, Jose, Handelsman, Yehuda, Guillen, Mario, Richwine, Randall, Lewy-Alterbaum, Lorena, Corder, Clinton, Arvind, Moogali, Bolshoun, David, Mikhail, Magdy, Minton, Stephen, Alvarado, Odilon, Abbott, J, Cauthen, Brett, Welter, Ryan, Mintz, Randy, Cox, John, Quick, Annette, Weiss, Melvin, Dy, Johnny, Zebrack, James, Gandelman, Glenn, Hegde, Vinayak, Silver, Marc, DeGregorio, Michele, Lawson, William, Paa, Christopher, Bortnick, Anna, Krolick, Merrill, Sotolongo, Rodolfo, Cheirif, Jorge, Kumar, Priya, Nadar, Venkatesh, Jetty, Preetham, Patel, Ambar, Kruk, Mariusz, Kobielusz-Gembala, Iwona, Rewerska, Barbara, Madrzejewski, Adam, Milewski, Krzysztof, Cygler, Jerzy, Petryka-Mazurkiewicz, Joanna, Jastrzebski, Waldemar, Korecki, Janusz, Fil, Wojciech, Prokopczuk, Janusz, Bochenek, Anna, Wujkowski, Marek, Witek, Robert, Konczakowski, Piotr, Miekus, Pawel, Szczasny, Marcin, Musial, Wlodzimierz, Cymerman, Krzysztof, Lampart, Jacek, Mikosinski, Jacek, Szynal, Slawomir, Fares, Issa, Opolski, Grzegorz, Mazur, Stanislaw, Wozakowska-Kaplon, Beata, Bijata-Bronisz, Renata, Wierucki, Lukasz, Losa, Beata, Drelich, Grzegorz, Konieczny, Marek, Starczewski, Pawel, Pawlowicz, Lidia, Jesionowski, Pawel, Jurowiecki, Jaroslaw, Gniot, Jacek, Czyzycki, Mariusz, Stania, Karol, Kucharczyk-Bauman, Izabela, Busz-Papiez, Benita, Karczmarczyk, Agnieszka, Sudnik, Wanda, Koszek, Alina, Kolodziej, Piotr, Skwarna, Bartosz, Jaramillo, Nicolás, Jankowski, Maciej, Czochra, Wojciech, Kinasz, Leszek, Miklaszewicz, Beata, Stasinska, Teresa, Pluta, Wladyslaw, Basiak, Marcin, Rusicka, Teresa, Niedbal-Yahfouf, Izabela, Popenda, Grazyna, Korzeniak, Romuald, Mirek, Agnieszka, Mariankowski, Rafal, Wojnowski, Lukasz, Korol, Marek, Baszak, Jacek, Podolec, Piotr, Piesiewicz, Wojciech, Zurakowski, Aleksander, Luengas, Carlos, Skura, Marek, Pilecki, Piotr, Majchrzak, Piotr, Krzyzagórska, Ewa, Drozd, Marcin, Kaczmarek, Barbara, Sliwinska, Teresa, Zelazowska, Katarzyna, Sztembis, Rafal, Landa, Katarzyna, Matyszczak-Toniak, Lidia, Strojek, Krzysztof, Piepiorka, Marek, Malinowski, Robert, Górska, Maria, Stolarczyk-Sowa, Edyta, Romanowski, Leszek, Zinka, Elzbieta, Reszka, Zygfryd, Skierkowska, Joanna, Uzunow, Anna, Laskowska-Derlaga, Ewa, Puntus, Ekaterina, Kosmacheva, Elena D, Koziolova, Natalia, Pavlov, Prokhor, Supryadkina, Tatiana, Didenko, Yury, Kopylov, Philipp, Kazakov, Andrei, Aksentiev, Sergei, Vishneva, Elena, Repin, Alexey, Smolenskaya, Olga, Mantserova, Olga, Khrustalev, Oleg, Privalova, Elena, Konstantinov, Vladimir, Boldueva, Svetlana, Ezhov, Andrey, Chernyavsky, Alexander, Kamalov, Gadel, Galyavich, Albert, Zubeeva, Galina, Nechaeva, Galina, Shustov, Sergey, Dzhaiani, Nino, Treshkur, Tatiana, Osokina, Nataliya, Panov, Alexey, Shutemova, Elena, Makukhin, Valeriy, Kropotina, Tatiana, Tsyba, Larisa, Karpov, Yuri, Sizova, J M, Ballyuzek, Marina, Tarasov, Nikolay, Demchenko, Elena, Barbarash, Olga, Moiseev, Valentin, Markov, Valentin, Kuznetsov, Vadim, Viktorova, Inna, Sergienko, Igor, Ermoshkina, Lyudmila, Khasanov, Niyaz, Khlevchuk, Tatiana, Baglikov, Andrey, Shalaev, Sergey, Zonova, Elena, Reznik, Elena, Haisheva, Larisa, Morugova, Tatyana, Lomakin, Nikita, Vishnevsky, Alexander, Shvarts, Yuri, Magnitskaya, Olga, Mikhailusova, Marina, Pavlysh, Elena, Libov, Igor, Zateyschikova, Anna, Kostenko, Victor, Edin, Anton, Khovaeva, Yaroslava, Zakharov, Konstantin, Stryuk, Raisa, Khirmanov, Vladimir, Kanorskiy, Sergey, Yakushin, Sergey, Barabashkina, Anna, Li, Hongwei, Zhao, Qiang, Zhang, Jian, Ma, Jianhua, He, Yong, Luo, Ming, Zhang, Aidong, Zhang, Ningru, Chai, Yingru, Ma, Genshan, Wang, Hao, Liu, Zhigang, He, Lanjie, Song, Zhifang, Dong, Xiaolin, Tao, Liang, Li, Zhanquan, Su, Xi, Kong, Xiangqing, Niu, Heping, Ge, Junbo, Luo, Zhurong, Huang, Wenjun, Peng, Daoquan, Yuan, Zuyi, Milanova, Maria, Tenev, Doncho, Gogov, Antoni, Karageorgiev, Dimitar, Kolchev, Todor, Rusev, Nikolay, Georgieva, Nikolina, Kondov, Rumen, Rusinov, Veselin, Petrov, Ivo, Stanchev, Georgi, Konteva, Mariana, Dincheva, Adriana, Yaneva, Zdravka, Vatova, Ralitsa, Ilieva, Katya, Runev, Nikolai, Kolomanov, Borislav, Petrov, Ivan, Iliev, Nikolay, Tisheva, Snezhanka, Chompalova, Boryana, Tokmakova, Maria, Raev, Dimitar, Byanov, Kolyo, Markov, Dimitar, Mihov, Lenko, Mihov, Atanas, Milcheva, Nora, Minchev, Milen, Mollov, Mihail, Borisov, Borislav, Tihchev, Tihomir, Karakolev, Venelin, Dimov, Bojidar, Georgiev, Svetoslav, Smilov, Lachezar, Koo, Bon K, Ahn, Taehoon, Hong, Soon J, Yoon, Junghan, Oh, Seok K, Jeong, Myung H, Kim, Doo-Il, Chang, Kiyuk, Kim, Weon, Hahn, Joo-Yong, Cha, Kwang S, Lee, Jung-Hee, Choi, Si-Wan, Nam, Chang-Wook, Chae, In-Ho, Park, Yong H, Tahk, Seung-Jea, Shin, Won-Yong, Chae, Jei-Keon, Kim, Byung J, Bae, Jang-Whan, Park, Woo J, Rha, Seung W, Choi, Young J, Hwang, Jin-Yong, Park, Hun S, Baracioli, Luciano, Guimaraes, Fabio, Vasconcellos, Eduardo, Saraiva, José, Pereira, Adamastor, Santos, Queulla, Rossi, Paulo, Maia, Lilia, Madeira, Miguel, Pereira, Marcio, Botelho, Roberto, Reis, Gilmar, Eliaschewitz, Freddy, Borges, Joao, Nascimento, Carlos, Fortes, Jose A, de Souza, Weimar, Pimentel, Pedro, Hissa, Miguel, Franchetti, Marcos, Precoma, Dalton, Ortiz, Costantino, Hernandes, Mauro, Saporito, Wladmir, dos Santos, Fabio R, Kormann, Adrian, Neuenschwander, Fernando, Dutra, Oscar, Rassi, Nelson, Tanajura, Luiz, Souza, Juliana, Junior, Delcio S, Leaes, Paulo, Forte, Adriana, Bonansea, Teresa C, Marin, Jose, Machado, Bruno, Cerqueira, Maria J, Silva, Frederico, Michalaros, Yorghos, Manenti, Euler, Cercato, Cintia, Figueiredo, Estevao, Liu, Ming-En, Wang, Yi-Chih, Lee, Tsung-Ming, Fang, Chih, Wu, Yen-Wen, Ueng, Kwo-Chang, Sheu, Huey-Herng, Lai, Wen T, Hsieh, I-Chang, Chen, Zhih-Cherng, Lee, Mu-Jang, Chiang, Chern, Shyu, Kou-Gi, Hsia, Chien-Hsun, Mar, Guang-Yuan, Chan, Shih-Hung, Wu, Chih-Cheng, Tseng, Wei-Kung, Chang, Kuan-Cheng, Yeh, Hung-I, Wang, Ji-Hung, Hou, Charles, Sorokina, Inna, Dolzhenko, Maryna, Horoshko, Olha, Karpenko, Oleksandr, Rudenko, Leonid, Vakaliuk, Igor, Kulyk, Anna, Levchenko, Olena, Prokhorov, Oleksandr, Reshotko, Dmytro, Sorokivskyy, Mykhaylo, Velichko, Nataliia, Maslovskyi, Valentyn, Teliatnikova, Zinaida, Dotsenko, Sergiy, Krakhmalova, Olena, Kraiz, Igor, Zharinova, Viktoria, Bula, Larysa, Kaydashev, Igor, Molodtsov, Valeriy, Rasputina, Lesya, Pidlisna, Viktoriya, Lysunets, Olena, Kravchenko, Anatoliy, Glushko, Liubomyr, Khomazyuk, Tetyana, Svyshchenko, Yevgeniya, Parkhomenko, Oleksandr, Mankovsky, Boris, Abrahamovych, Orest, Yagensky, Andriy, Stanislavchuk, Mykola, Vasilyeva, Larisa, Sokolova, Liubov, Sychov, Oleg, Tseluyko, Vira, Kyrychenko, Igor, Rishko, Mykola, Furkalo, Sergiy, Gallo, Richard, Bertrand, Olivier, Mehta, Shamir, Constance, Christian, Sussex, Bruce, Zadra, Remo, Kouz, Simon, Chehayeb, Raja, Pandey, Amritanshu, Dion, Danielle, Bailey, Gordon, Hill, Laurie, Ramanathan, Krishnan, Dorsch, Micha, Nanji, Alykhan, Babapulle, Mohan, Montigny, Martine, Gosselin, Gilbert, Dehghani, Payam, Rupka, Dennis, Le May, Michel, Pichette, Francis, St-Maurice, Francois, Teefy, Patrick, Mansour, Samer, Kassam, Saleem, Cheung, Stephen, Siega, Anthony D, O'Keefe, Dennis, Sabbah, Eric, Bell, Alan, Chouinard, Guy, Wong, Brian, Miller, Mark, Gaudet, Daniel, Lachance, Pierre, Bata, Iqbal, Petrella, Robert, Gossard, Denis, Dumas, Richard, Ing, Douglas, Boyrazian, Hagop, Bessoudo, Ricardo, Huynh, Thao T, Hart, Randy, Belle-Isle, Jasmin, Shukla, Dinkar, Kelly, Allan, Mazza, Giuseppe, Cha, James, Henein, Sam, Frechette, Andre, Vizel, Saul, Liutkus, Joanne F, O'Mahony, Michael, Halperin, Frank, Kooy, Jacobus, Graham, John, Bailey, Allan, Wojcik, Ronald, Wilderman, Igor, Turi, Tibor, Motyovszki, Ákos, Merkely, Béla, Király, Csaba, Andrássy, Péter, Sárszegi, Zsolt, Fülöp, Tibor, Zilahi, Zsolt, Édes, István, Papp, Andras, Müller, Gábor, Czigány, Anna, Zólyomi, Szilárd, Korányi, László, Takács, János, Juhász, Ferenc, Benczur, Bela, Kancz, Sándor, Földi, András, Nagy, András C, Bakai, Judit, Greschik, István, Püski, László, Nagy, László, Kirschner, Róbert, Kuchar, Roman, Hajek, Petr, Busak, Ladislav, Michalik, Daniel, Matyasek, Ivo, Marusincova, Ivana, Kucera, Dusan, Jerabek, Ondrej, Honkova, Michaela, Dedek, Vratislav, Rihacek, Ivan, Kos, Pavel, Slaby, Josef, Machkova, Martina, Zidkova, Eva, Elbl, Lubomir, Grunfeldova, Hana, Carda, Jiri, Mrozek, Vladimir, Maly, Jiri, Milkovic, Richard, Malecha, Jan, Skalicka, Hana, Oral, Ivo, Krcova, Eva, Lisa, Libor, Belohlavek, Jan, Miklik, Roman, Cermak, Ondrej, Bednarova, Jana, Peroutka, Zdenek, Spinar, Jindrich, Wilke, Andreas, Appel, Karl-Friedrich, Taggeselle, Jens, Förster, Andreas, Toursarkissian, Nicole, Schmidt, Ekkehard, Bott, Jochen, Al-Zoebi, Ayham, Hennig, Dirk, Fischer, Sabine, Schön, Norbert, Sauter, Joachim, Simonis, Gregor, Nischik, Ruth, Rieker, Werner, Schenkenberger, Isabelle, Behnke, Thomas, Klausmann, Gerhard, Jeserich, Michael, Trenk, Dietmar, Weigmann, Ingo, Reuter, Hannes, Rummel, Reinhard, von Münchhausen, Candy, von Engelhardt, Charlotte, Horibe, Eishun, Shibasaki, Taro, Sato, Tomohiko, Kakuta, Tsunekazu, Michishita, Ichiro, Tan, Michinao, Ishiki, Ryoji, Aoyama, Takahiko, Higashiue, Shinichi, Niijima, Yawara, Idogaki, Akira, Hasegawa, Toru, Kiyosue, Arihiro, Tomobuchi, Yoshiaki, Kawamitsu, Katsunori, Kawasaki, Satsuki, Hata, Yoshiki, Fukui, Kazuki, Seki, Kozaburo, Takenaka, Takashi, Abe, Mitsuru, Utsu, Noriaki, Oono, Atsuyuki, Mitsuo, Kazuhisa, Sueyoshi, Atsushi, Hirohata, Atsushi, Tsujimoto, Mitsuru, Ueda, Osamu, Takase, Shinichi, Suzuki, Masahiro, Sakuragi, Satoru, Yamamoto, Fumi, Fujimoto, Noritaka, Kakinoki, Shigeo, Sugiura, Tatsushi, Sugino, Hiroshi, Nakamura, Toshihiro, Goto, Shinya, Kadokami, Toshiaki, Uehara, Hiroki, Ono, Masahiro, Yokoya, Koichi, Koike, Akihiro, Komatsu, Sei, Sonoda, Masahiro, Ueno, Hideki, Doi, Tomofumi, Takagi, Yuichiro, Fujimoto, Kazuteru, Eki, Yutaka, Okubo, Munenori, Sasaki, Kenichiro, van Eck, Martijn, Ronner, Eelko, The, Salem, van de Wal, Ruud, Nierop, Pieter, de Nooijer, Cornelis, The, Salem, The, Salem, Werner, Henri, Westendorp, Iris, van der Zwaan, Coen, Crijns, Hendrikus, Cornel, Jan H, Strikwerda, Sipke, Bos, Robert, de Melker, Edwin, Kuijper, Adrianus, Louwerenburg, Hans, Plomp, Jacobus, Dantzig, Jan-Melle, Prins, Francisco, van Kesteren, Henricus, Willems, Frank, Amoroso, Giovanni, Carnero, Gabriela, Duronto, Ernesto, Besada, Diego, Chacon, Carolina, Zangroniz, Pedro, Solis, Silvana, Liberman, Alberto, Sernia, Virginia, Alvarisqueta, Andres, Maffei, Laura, Vilamajo, Oscar G, García, Celso, Sicer, Maximiliano, Muntaner, Juan, Bordonava, Anselmo, Albisu, Juan, Zanini, Alejandra, Rista, Lucas, Hominal, Miguel, Estrada, José N, Prado, Aldo, Gosparini, Diego M, Schiavi, Beatriz, Castillo, Armando G, Ruíz, José G, Martinez, Guillermo R, López, Víctor G, Rosas, Enrique L, Lopez, Gabriel R, Cantu, Elias G, de los Ríos Ibarra, Manuel, Padilla, Francisco P, Carrasco, Jose P, Carrillo, Luis V, García, Joel D, Askar, Alfredo N, Salinas, Carlos A, Gamba, Marco A, Sanchez, Carlos G, Cantú, Arnulfo G, Sánchez, Raul V, Madrigal, Jaime C, Urbano, Rafael H, Romo, Andrés Í, González Juanatey, José R, Racugno, Paolo, Fillat, Angel C, de la Torre Hernández, José M, Peláez, Juan A, Cortada, Jorge B, Pavia, Pablo G, Navarro, Manuel J, Asenjo, Roberto M, Díaz, Francisco F, Peligero, Eduard B, Manterola, Fernando A, Ortiz, Antonio F, Mediavilla García, Juan D, Ortuño, Francisco M, Vera, Tomás R, González, Alfonso S, Viñas, Jaime A, Fernández Portales, Francisco J, Mayordomo, Petra S, Ojeda, Francisco B, Domínguez, Antonio R, González, Rosa S, Guerrero, Diego B, Ruiz Nodar, Juan M, Marimon, Xavier G, Margáez, José G, Aguilera, Roberto M, Díaz Fernández, José F, Zamorano Gómez, José L, González, Vicente B, del Blanco, Bruno G, Pérez, Ignacio P, Moreno, Mercé R, Ereño, Ainhoa R, García Lledó, José A, Prieto, Juan, Villablanca, Alex, Raffo, Carlos, Pincetti, Christian, Conejeros, Carlos, Roman, Oscar, Rodriguez, Manuel, Varleta, Paola, Goldberg, Cindy, Sandoval, Jorge, Arriagada, German, Leon, Lucio, Potthoff, Sergio, Cobos, Jorge, Figueroa, Christian, Makotoko, Ellen, Fourie, Nyda, Burgess, Lesley, Nortje, Hendrik, Theron, Rust, Pillai, Perumal, Ranjith, Naresh, Trokis, Julien, Pillay, Soobramoney, Reddy, Jeevren, Nunkoo, Theema, Kapp, Cornelia, Urbach, Dorothea, Distiller, Lawrence, Horak, Adrian, van Zyl, Louis, Coetzee, Kathleen, Punt, Zelda, Bayat, Junaid, Dawood, Saleem, Mitha, Ismail, Padayachee, Trevenesan, Hoosen, Farzana, Dalby, Anthony, Prabhavathi, Gowdaiah, Prakash, Mehta, Vimal, Chag, Milan, Gadkari, Milind, Ramamurthee, Kannaiyan, Das, Asit, Sawhney, Jitendra S, Banerjee, Suvro, Sathe, Prachee, Adhyapak, Srilakshmi, Nguyen, Tuan, Pham, Vinh, Do, Huan, Nguyen, Anh, Nguyen, Hien, Truong, Binh, Jamil-Copley, Shahnaz, Lang, Chim, Pell, Alastair, Zaman, Azfar, Storey, Robert, Swanson, Neil, Smith, Simon, Sharman, David, Braganza, Denise, Hammond, Peter, Moriarty, Andrew, Bain, Stephen, Pye, Maurice, Sharp, Andrew, Blagden, Mark, Randeva, Harpal, Myhill, Timothy, Viswanathan, Girish, Keeling, Philip, Clifford, Piers, Saxena, Manish, Lyons, Kristopher, McMurray, John, Jaafar, Feeroz, Murphy, Clare, Cartwright, Simon, Abouglila, Kamal, Antalik, Lubomir, Krajci, Peter, Urban, Miroslav, Fazekas, Frantisek, Pella, Daniel, Koleny, Daniel, Vykoukalova, Tatiana, Macek, Vladimir, Vinanska, Daniela, Jamriskova, Livia, Such, Slavomir, Fulop, Peter, Farsky, Stefan, Bugan, Viliam, Strbova, Jaroslava, Micko, Karol, Palka Jr, Juraj, Sivak, Vladimir, Kristensen, Dalby, Refsgaard, Jens, Holmvang, Lene, Dixen, Ulrik, Nielsen, Henrik, Egstrup, Kenneth, Jensen, Lisette O, Sykulski, Roman, Rasmussen, Ole, Andries, Alin, Luckow, Anders, Nielsen, Gitte, Sørensen, Torben, Wongvipaporn, Chaiyasith, Chamnarnphol, Noppadol, Srimahachota, Suphot, Sansanayudh, Nakarin, Kuanprasert, Srun, Tresukosol, Damras, Sookananchai, Bancha, Kanadasi, Mehmet, Ozcan, Turkay, Kucuk, Murathan, Ongen, Zeki, Okuyan, Ertugrul, Arat, Alev, Acikel, Sadik, Yalcin, Ahmet, Guray, Umit, Ceyhan, Ceyhun, Ozer, Necla, Arslan, Sakir, Angerås, Oskar, Johnston, Nina, Weiderman, Ann-Charlotte, Bandh, Stellan, Hansen, Ole, Larnefeldt, Hans, Kusiak, Dawid, Lindholm, Carl-Johan, Hedman, Anders, Erlinge, David, Curiac, Dan, Lundman, Pia, Zucconi-Mazzini, Roberto, Aladellie, Layth, Jensen, Jens, Verwerft, Jan, Vrolix, Mathias, Faes, Dirk, Striekwold, Harry, Sinnaeve, Peter, Timmermans, Patrick, Guedes, Antoine, Delforge, Marc, Nimmegeers, Jan, Stammen, Francis, Buysschaert, Ian, Hoffer, Etienne, Hollanders, Geert, Vervoort, Geert, Coussement, Patrick, de Maeseneire, Stefan, Janssens, Luc, Gravdal, Stein A, Risberg, Knut, Gullestad, Lars, Hofseth, Ola D, Nilsen, Dennis, Lappegård, Knut T, van den Heuvel, Christian, Gibbs, Charlotte, Khusrawi, Alamdar, Arora, Satish, Tomala, Tadeusz, Kjærnli, Thorbjørn, Berg-Johansen, Jan, Hagemeier, Robert, Skjelvan, Gunnar, Colquhoun, David, Amerena, John, Morbey, Claire, Hammett, Christopher, Dart, Anthony, Lehman, Ronald, Hamilton, Andrew, Worthley, Matthew, Purnell, Peter, Whelan, Alan, MacIsaac, Richard, Arya, Ktut, Linjawi, Sultan, Proietto, Joseph, Prasad, Lakshman, Rodriguez, Aldo, Godoy, Armando, Rodriguez, Victor, Berrospi, Percy, Chavez, Carlos, Negron, Sandra, Heredia, Javier, Medina, Felix, Manrique, Helard, Cabrera, Walter, Cordova, Fernando, Quinteros, Trinidad, Haro, Jaime M, Regalado, Susana, Guitton, Javier, Arbanil, Hugo, Pansieri, Michel, Decoulx, Eric, Goube, Pascal, de Labriolle, Axel, Labeque, Jean N, Range, Gregoire, Cottin, Yves, Montalescot, Gilles, Cayla, Guillaume, Danchin, Nicolas, Angoulvant, Denis, Ferrario, Emile, Elbaz, Meyer, Dubreuil, Olivier, Steg, Philippe G, Fontaine, Caroline, Sorbets, Emmanuel, Omer, Hafiz, Al-Saif, Shukri, Al-Faleh, Hussam, Al-Shehri, Abdullah, Alshehri, Halia, Bazari, Rasha, Hei, Pak, Ying, Man, Chan, Michael, Wong, Michelle, Ma, Ronald, Siu, Shing C, Tsang, Chiu C, Ferrario, Maurizio, Assanelli, Emilio, Senni, Michele, Piatti, Piermarco, Calabrò, Paolo, Urbinati, Stefano, Michisanti, Massimo, Varbella, Ferdinando, de Cosmo, Salvatore, Trevisan, Roberto, Bellotti, Sandro, Di Pasquale, Giuseppe, Bongo, Angelo S, Uguccioni, Massimo, Mannucci, Edoardo, Mauro, Ciro, Ragonese, Mauro, Fresco, Claudio, Turturo, Maurizio, Marcucci, Rossella, Lievano Triana, Manuel J, Arana, Camilo, Accini, Jose, Botero, Rodrigo, Muzyk-Osikowicz, Marlena, Dada, Fredy T, Vallejo, Gregorio S, Manzur, Fernando, Isaza, Daniel, Molina, Dora, Mesa, Juan G, Quintero, Alvaro, Nyman, Kai, Mäkelä, Jyrki, Strand, Jorma, Nieminen, Sakari, Taurio, Jyrki, Kuusela, Matti, Valle, Timo, Pietilä, Mikko, Kekki, Sakari, Strandberg, Timo, Klutstein, Marc, Greenberg, Gabriel, Rozenman, Yoseph, Chorin, Ehud, Roguin, Ariel, Lewis, Basil, Bashkin, Amir, Tan, Edgar, Prado, Jose P, Ferrolino, Arthur, Babilonia, Noe, Barbas, Benny, Matiga, Generoso, Coching, Raul M, Drexel, Heinz, Brath, Helmut, Schnack, Christoph, Hanusch, Ursula, Fließer-Görzer, Evelyn, Paulweber, Bernhard, Ebenbichler, Christoph, Prager, Rudolf, Huber, Kurt, Wolzt, Michael, Auer, Johann, Berger, Rudolf, Schernthaner, Gerit-Holger, Stanciulescu, Gabriela, Creteanu, Mihai, Spiridon, Marilena, Dobreanu, Viorica, Vinereanu, Dragos, Iosipescu, Laura C, Istratoaie, Octavian, Coman, Ioan, Militaru, Constantin, Cinteza, Mircea, Bhatt, Deepak L, Fox, Kim, Harrington, Robert A, Leiter, Lawrence A, Mehta, Shamir R, Simon, Tabassome, Andersson, Marielle, Himmelmann, Anders, Steg, Philippe G, Diaz, Rafael, Amerena, John, Huber, Kurt, Sinnaeve, Peter R, Nicolau, José C, Kerr Saraiva, José F, Petrov, Ivo, Leiter, Lawrence A, Mehta, Shamir R, Corbalán, Ramón, Ge, Junbo, Zhao, Qiang, Botero, Rodrigo, Widimský, Petr, Kristensen, Steen D, Hartikainen, Juha, Danchin, Nicolas, Darius, Harald, Tse, Hung F, Kiss, Robert G, Pais, Prem, Lev, Eli, de Luca, Leonardo, Goto, Shinya, Ramos López, Gabriel A, Cornel, Jan H, Kontny, Frederic, Medina, Felix, Babilonia, Noe A, Opolski, Grzegorz, Vinereanu, Dragos, Zateyshchikov, Dmitry A, Ruda, Mikhail, Elamin, Omer, Kovář, František, Dalby, Anthony J, Jeong, Myung H, Bueno, Héctor, James, Stefan K, Chiang, Chern-En, Tresukosol, Damras, Ongen, Zeki, Ray, Kausik K, Parkhomenko, Alexander, McGuire, Darren K, Kosiborod, Mikhail N, Nguyen, Tuan Q, Andersson, Marielle, Chen, Jersey, Himmelmann, Anders, Leonsson-Zachrisson, Maria, and Ridderstråle, Wilhelm

Abstract

Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin. In this trial, we aimed to investigate if these patients would benefit from treatment with aspirin plus ticagrelor.

Published
2019
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61. Histopathological evaluation of thrombus in patients presenting with stent thrombosis. A multicenter European study: a report of the prevention of late stent thrombosis by an interdisciplinary global European effort consortium

Author

Riegger, Julia, Byrne, Robert A., Joner, Michael, Chandraratne, Sue, Gershlick, Anthony H., ten Berg, Jurrien M., Adriaenssens, Tom, Guagliumi, Giulio, Godschalk, Thea C., Neumann, Franz-Josef, Trenk, Dietmar, Feldman, Laurent J., Steg, Philippe Gabriel, Desmet, Walter, Alfonso, Fernando, Goodall, Alison H., Wojdyla, Roman, Dudek, Dariusz, Philippi, Vanessa, Opinaldo, Sheryl, Titova, Anna, Malik, Nikesh, Cotton, James, Jhagroe, Darshni A., Heestermans, Antonius A.C.M., Sinnaeve, Peter, Vermeersch, Paul, Valina, Christian, Schulz, Christian, Kastrati, Adnan, Massberg, Steffen, Buysschaert, Ian, Chausson, Mickaël, De Cock, Dries, Dens, Jo, Barbato, Emanuele, Gautier, Sandrine, Abergel, Helene, Feldman, Laurent, Jandrot-Perrus, Martine, Letourneur, Didier, Mangin, Pierre, Olivier, Véronique, Roques, Caroline, Gratz, Matthias, Kennerknecht, Elisabeth, Konrad, Ildiko, Koppara, Tobias, Ntziachristos, Vasilis, Rosenthal, Amir, Rzany, Alexander, Steigerwald, Kristin, Tada, Tomohiso, Vogelsang, Andreas, Xhepa, Erion, Bernelli, Chiara, Coccato, Micol, Komukai, Kenichi, Sirbu, Vasile, Kerch, Garry, Amoroso, Giovanni, ten Berg, Jurriën, Dewilde, Willem J.M., Wykrzykowska, Joanne J., Winkens, Mark H.M., Rzeszutko, Łukasz, Zasada, Wojciech, Cuesta, Javier, Medina, Miguel, Berry, Colin, Curzen, Nick, McEntegart, Margaret, Gerber, Robert, Gershlick, Anthony, Hetherington, Simon, Hill, Jonathan, Kelly, Damian, Oldroyd, Keith, Routledge, Helen, Shannon, Joanne, Suresh, Venkatesan, Zahman, Azfar, Riegger, Julia, Byrne, Robert A, Joner, Michael, Chandraratne, Sue, Gershlick, Anthony H, Ten Berg, Jurrien M, Adriaenssens, Tom, Guagliumi, Giulio, Godschalk, Thea C, Neumann, Franz Josef, Trenk, Dietmar, Feldman, Laurent J, Steg, Philippe Gabriel, Desmet, Walter, Barbato, Emanuele, Alfonso, Fernando, Goodall, Alison H, Wojdyla, Roman, Dudek, Dariusz, Philippi, Vanessa, Opinaldo, Sheryl, Titova, Anna, Malik, Nikesh, Cotton, Jame, Jhagroe, Darshni A, Heestermans, Antonius A. C. M, Sinnaeve, Peter, Vermeersch, Paul, Valina, Christian, Schulz, Christian, Kastrati, Adnan, Massberg, Steffen, Department of Embryology and Genetics, Cardio-vascular diseases, Clinical sciences, and Follicle Biology

Subjects
Male, 0301 basic medicine, Cardiac & Cardiovascular Systems, Stent thrombosi, Stent thrombosis, Neutrophils, medicine.medical_treatment, Eosinophil, 030204 cardiovascular system & hematology, Fibrinogen, Neutrophil extracellular traps, ESC FASTTRACK, VIVO, Leukocyte Count, 0302 clinical medicine, Coronary thrombosis, Prospective Studies, Myocardial infarction, HYPERSENSITIVITY, Thrombectomy, RISK, biology, Neutrophil, Platelet, Graft Occlusion, Vascular, Drug-Eluting Stents, ddc, Prosthesis Failure, 3. Good health, cardiovascular system, ESC Basic and Translational Science Hot Line, Fast Track, Female, Stents, Cardiology and Cardiovascular Medicine, Life Sciences & Biomedicine, circulatory and respiratory physiology, medicine.drug, Platelets, Blood Platelets, medicine.medical_specialty, Thrombus aspiration, COAGULATION, Prevention of Late Stent Thrombosis by an Interdisciplinary Global European Effort (PRESTIGE) Investigators, Histopathology, 1102 Cardiovascular Medicine And Haematology, Fibrin, 03 medical and health sciences, Percutaneous Coronary Intervention, medicine, Humans, cardiovascular diseases, Thrombus, Aged, Science & Technology, business.industry, ACUTE CORONARY SYNDROMES, Coronary Thrombosis, Stent, Percutaneous coronary intervention, Thrombosis, medicine.disease, Lymphocyte Subsets, Surgery, Eosinophils, 030104 developmental biology, Cardiovascular System & Hematology, Cardiovascular System & Cardiology, INNATE IMMUNITY, biology.protein, IMPLANTATION, business, Complication, Neutrophil extracellular trap, GENERATION
Abstract

BACKGROUND: Stent thrombosis (ST) is a rare but serious complication following percutaneous coronary intervention. Analysis of thrombus composition from patients undergoing catheter thrombectomy may provide important insights into the pathological processes leading to thrombus formation. We performed a large-scale multicentre study to evaluate thrombus specimens in patients with ST across Europe. METHODS: Patients presenting with ST and undergoing thrombus aspiration were eligible for inclusion. Thrombus collection was performed according to a standardized protocol and specimens were analysed histologically at a core laboratory. Serial tissue cross sections were stained with haematoxylin-eosin (H&E), Carstairs and Luna. Immunohistochemistry was performed to identify leukocyte subsets, prothrombotic neutrophil extracellular traps (NETs), erythrocytes, platelets, and fibrinogen. RESULTS: Overall 253 thrombus specimens were analysed; 79 (31.2%) from patients presenting with early ST, 174 (68.8%) from late ST; 79 (31.2%) were from bare metal stents, 166 (65.6%) from drug-eluting stents, 8 (3.2%) were from stents of unknown type. Thrombus specimens displayed heterogeneous morphology with platelet-rich thrombus and fibrin/fibrinogen fragments most abundant; mean platelet coverage was 57% of thrombus area. Leukocyte infiltrations were hallmarks of both early and late ST (early: 2260 ± 1550 per mm(2) vs. late: 2485 ± 1778 per mm(2); P = 0.44); neutrophils represented the most prominent subset (early: 1364 ± 923 per mm(2) vs. late: 1428 ± 1023 per mm(2); P = 0.81). Leukocyte counts were significantly higher compared with a control group of patients with thrombus aspiration in spontaneous myocardial infarction. Neutrophil extracellular traps were observed in 23% of samples. Eosinophils were present in all stent types, with higher numbers in patients with late ST in sirolimus-and everolimus-eluting stents. CONCLUSION: In a large-scale study of histological thrombus analysis from patients presenting with ST, thrombus specimens displayed heterogeneous morphology. Recruitment of leukocytes, particularly neutrophils, appears to be a hallmark of ST. The presence of NETs supports their pathophysiological relevance. Eosinophil recruitment suggests an allergic component to the process of ST. ispartof: European Heart Journal vol:37 issue:19 pages:1538-1549 ispartof: location:England status: published

Published
2015
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62. Ticagrelor plus aspirin for 1 month, followed by ticagrelor monotherapy for 23 months vsaspirin plus clopidogrel or ticagrelor for 12 months, followed by aspirin monotherapy for 12 months after implantation of a drug-eluting stent: a multicentre, open-label, randomised superiority trial

Author

Vranckx, Pascal, Valgimigli, Marco, Jüni, Peter, Hamm, Christian, Steg, Philippe Gabriel, Heg, Dik, van Es, Gerrit Anne, McFadden, Eugene P, Onuma, Yoshinobu, van Meijeren, Cokky, Chichareon, Ply, Benit, Edouard, Möllmann, Helge, Janssens, Luc, Ferrario, Maurizio, Moschovitis, Aris, Zurakowski, Aleksander, Dominici, Marcello, Van Geuns, Robert Jan, Huber, Kurt, Slagboom, Ton, Serruys, Patrick W, Windecker, Stephan, Abdellaoui, Mohamed, Adlam, David, Akin, Ibrahim, Albarran Gonzalez-Trevilla, Agustin, Almeida, Manuel, Alves Lemos Neto, Pedro, Aminian, Adel, Anderson, Richard, Andreae, Rick, Angioi, Michael, Asano, Taku, Barbato, Emanuele, Barlis, Peter, Barraud, Pascal, Benit, Edouard, Bertrand, Olivier, Beygui, Farzin, Bolognese, Leonardo, Botelho, Roberto, Bouwman, Coby, Bressers, Marco, Brunel, Philippe, Buszman, Pawel, Buysschaert, Ian, Canas da Silva, Pedro, Carrie, Didier, Cequier, Angel, Chichareon, Ply, Chin Chang, Chun, Chowdhary, Saqib, Collet, Carlos, Colombo, Antonio, Cotton, James, Cruz Ferreira, Rui, Curello, Salvatore, Curzen, Nick, de Bot, Judith, de Vreede, Tone, Delle Karth, Georg, Dijksma, Lynn, Dominici, Marcello, Édes, István, Eeckhout, Eric, Eitel, Ingo, Faluközy, József, Fath-Ordoubadi, Farzin, Ferrario, Maurizio, Fontos, Geza, Francisco Diaz, Jose, Freitas Quintella, Edgard, Frey, Bernhard, Friedrich, Guy, Galasko, Gavin, Galuszka, Grzegorz, Gama Ribeiro, Vasco, Garg, Scot, Gargiulo, Giuseppe, Geisler, Tobias, Gelev, Valeri, Ghandilyan, Art, Goicolea, Javier, Gori, Tommaso, Gragnano, Felice, Guimarães, Ana, Hamm, Christian, Haude, Michael, Heg, Dik, Heijke, Pieter, Hernández Antolin, Rosa Ana, Hildick-Smith, David, Hillen, Dorien, Hoekman, Ina, Hofma, Sjoerd, Holmvang, Lene, Hoole, Stephen, Horváth, Iván, Huber, Kurt, Hugense, Annemarie, Ibrahim, Karim, Iñiguez, Andres, Isaaz, Karl, Jambrik, Zoltán, Janssens, Luc, Jasionowicz, Pawel, Jonk, Judith, Jung, Werner, Jüni, Peter, Katagiri, Yuki, Kogame, Norihiro, Koh, Tian Hai, Koning, René, Konteva, Mariana, Kőszegi, Zsolt, Krackhardt, Florian, Kreuger, Yvonne, Kukreja, Neville, Ladan, Boudijn, Lantelme, Pierre, Leandro, Sergio, Leibundgut, Gregor, Liebetrau, Christoph, Lindeboom, Wietze, Macaya Miguel, Carlos, Mach, François, Magro, Michael, Maillard, Luc, Manavifar, Negar, Mauri, Laura, McFadden, Eugene, Merkely, Bela, Miyazaki, Yosuke, Młodziankowski, Adam, Moccetti, Tiziano, Modolo, Rodrigo, Möllman, Helge, Morelle, Jean-François, Moschovitis, Aris, Munndt Ottesen, Michael, Muurling, Martin, Naber, Christoph Kurt, Neumann, Franz-Josef, Oldroyd, Keith, Ong, Paul, Onuma, Yoshinobu, Palsrok, Sanne, Petrov, Ivo, Plante, Sylvain, Prokopczuk, Janusz, Rademaker-Havinga, Tessa, Raffel, Christopher, Rensing, Benno, Roffi, Marco, Royaards, Kees-Jan, Sabate, Manel, Schächinger, Volker, Seidler, Tim, Serra Peñaranda, Antonio, Serruys, Patrick, Sikarulidze, Lali, Slagboom, Ton, Soliman, Osama I, Sousa, Amanda, Spitzer, Ernest, Stables, Rod, Steg, Gabriel, Steinwender, Clemens, Subkovas, Eduardas, Suryapranata, Harry, Takahashi, Kuniaki, Talwar, Suneel, Teiger, Emmanuel, ter Weele, Addy, Teurlings, Eva, Thury, Attila, Tijssen, Jan, Tonev, Gincho, Trendafilova-Lazarova, Diana, Tumscitz, Carlo, Umans, Victor, Ungi, Imre, Valkov, Veselin, van der Harst, Pim, van Geuns, Robert Jan, van Meijeren, Cokky, Vassilev, Dobrin, Velchev, Vasil, Velthuizen, Esther, Verheugt, Freek, Vlcek, Natalia, vom Dahl, Jürgen, Vrolix, Mathias, Walsh, Simon, Werner, Nikos, Windecker, Stephan, Witsenburg, Maarten, Zaman, Azfar, Żmudka, Krzysztof, Zrenner, Bernhard, Zurakowski, Aleksander, and Zweiker, Robert

Abstract

We hypothesised that ticagrelor, in combination with aspirin for 1 month, followed by ticagrelor alone, improves outcomes after percutaneous coronary intervention compared with standard antiplatelet regimens.

Published
2018
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63. Plasma HDL cholesterol and risk of myocardial infarction : a mendelian randomisation study

Author

Voight, Benjamin F, Peloso, Gina M, Orho-Melander, Marju, Frikke-Schmidt, Ruth, Barbalic, Maja, Jensen, Majken K, Hindy, George, Hólm, Hilma, Ding, Eric L, Johnson, Toby, Schunkert, Heribert, Samani, Nilesh J, Clarke, Robert, Hopewell, Jemma C, Thompson, John F, Li, Mingyao, Thorleifsson, Gudmar, Newton-Cheh, Christopher, Musunuru, Kiran, Pirruccello, James P, Saleheen, Danish, Chen, Li, Stewart, Alexandre F R, Schillert, Arne, Thorsteinsdottir, Unnur, Thorgeirsson, Gudmundur, Anand, Sonia, Engert, James C, Morgan, Thomas, Spertus, John, Stoll, Monika, Berger, Klaus, Martinelli, Nicola, Girelli, Domenico, McKeown, Pascal P, Patterson, Christopher C, Epstein, Stephen E, Devaney, Joseph, Burnett, Mary-Susan, Mooser, Vincent, Ripatti, Samuli, Surakka, Ida, Nieminen, Markku S, Sinisalo, Juha, Lokki, Marja-Liisa, Perola, Markus, Havulinna, Aki, de Faire, Ulf, Gigante, Bruna, Ingelsson, Erik, Zeller, Tanja, Wild, Philipp, de Bakker, Paul I W, Klungel, Olaf H, Maitland-van der Zee, Anke-Hilse, Peters, Bas J M, de Boer, Anthonius, Grobbee, Diederick E, Kamphuisen, Pieter W, Deneer, Vera H M, Elbers, Clara C, Onland-Moret, N Charlotte, Hofker, Marten H, Wijmenga, Cisca, Verschuren, W M Monique, Boer, Jolanda M A, van der Schouw, Yvonne T, Rasheed, Asif, Frossard, Philippe, Demissie, Serkalem, Willer, Cristen, Do, Ron, Ordovas, Jose M, Abecasis, Gonçalo R, Boehnke, Michael, Mohlke, Karen L, Daly, Mark J, Guiducci, Candace, Burtt, Noël P, Surti, Aarti, Gonzalez, Elena, Purcell, Shaun, Gabriel, Stacey, Marrugat, Jaume, Peden, John, Erdmann, Jeanette, Diemert, Patrick, Willenborg, Christina, König, Inke R, Fischer, Marcus, Hengstenberg, Christian, Ziegler, Andreas, Buysschaert, Ian, Lambrechts, Diether, Van de Werf, Frans, Fox, Keith A, El Mokhtari, Nour Eddine, Rubin, Diana, Schrezenmeir, Jürgen, Schreiber, Stefan, Schäfer, Arne, Danesh, John, Blankenberg, Stefan, Roberts, Robert, McPherson, Ruth, Watkins, Hugh, Hall, Alistair S, Overvad, Kim, Rimm, Eric, Boerwinkle, Eric, Tybjaerg-Hansen, Anne, Cupples, L Adrienne, Reilly, Muredach P, Melander, Olle, Mannucci, Pier M, Ardissino, Diego, Siscovick, David, Elosua, Roberto, Stefansson, Kari, O'Donnell, Christopher J, Salomaa, Veikko, Rader, Daniel J, Peltonen, Leena, Schwartz, Stephen M, Altshuler, David, Kathiresan, Sekar, Voight, Benjamin F, Peloso, Gina M, Orho-Melander, Marju, Frikke-Schmidt, Ruth, Barbalic, Maja, Jensen, Majken K, Hindy, George, Hólm, Hilma, Ding, Eric L, Johnson, Toby, Schunkert, Heribert, Samani, Nilesh J, Clarke, Robert, Hopewell, Jemma C, Thompson, John F, Li, Mingyao, Thorleifsson, Gudmar, Newton-Cheh, Christopher, Musunuru, Kiran, Pirruccello, James P, Saleheen, Danish, Chen, Li, Stewart, Alexandre F R, Schillert, Arne, Thorsteinsdottir, Unnur, Thorgeirsson, Gudmundur, Anand, Sonia, Engert, James C, Morgan, Thomas, Spertus, John, Stoll, Monika, Berger, Klaus, Martinelli, Nicola, Girelli, Domenico, McKeown, Pascal P, Patterson, Christopher C, Epstein, Stephen E, Devaney, Joseph, Burnett, Mary-Susan, Mooser, Vincent, Ripatti, Samuli, Surakka, Ida, Nieminen, Markku S, Sinisalo, Juha, Lokki, Marja-Liisa, Perola, Markus, Havulinna, Aki, de Faire, Ulf, Gigante, Bruna, Ingelsson, Erik, Zeller, Tanja, Wild, Philipp, de Bakker, Paul I W, Klungel, Olaf H, Maitland-van der Zee, Anke-Hilse, Peters, Bas J M, de Boer, Anthonius, Grobbee, Diederick E, Kamphuisen, Pieter W, Deneer, Vera H M, Elbers, Clara C, Onland-Moret, N Charlotte, Hofker, Marten H, Wijmenga, Cisca, Verschuren, W M Monique, Boer, Jolanda M A, van der Schouw, Yvonne T, Rasheed, Asif, Frossard, Philippe, Demissie, Serkalem, Willer, Cristen, Do, Ron, Ordovas, Jose M, Abecasis, Gonçalo R, Boehnke, Michael, Mohlke, Karen L, Daly, Mark J, Guiducci, Candace, Burtt, Noël P, Surti, Aarti, Gonzalez, Elena, Purcell, Shaun, Gabriel, Stacey, Marrugat, Jaume, Peden, John, Erdmann, Jeanette, Diemert, Patrick, Willenborg, Christina, König, Inke R, Fischer, Marcus, Hengstenberg, Christian, Ziegler, Andreas, Buysschaert, Ian, Lambrechts, Diether, Van de Werf, Frans, Fox, Keith A, El Mokhtari, Nour Eddine, Rubin, Diana, Schrezenmeir, Jürgen, Schreiber, Stefan, Schäfer, Arne, Danesh, John, Blankenberg, Stefan, Roberts, Robert, McPherson, Ruth, Watkins, Hugh, Hall, Alistair S, Overvad, Kim, Rimm, Eric, Boerwinkle, Eric, Tybjaerg-Hansen, Anne, Cupples, L Adrienne, Reilly, Muredach P, Melander, Olle, Mannucci, Pier M, Ardissino, Diego, Siscovick, David, Elosua, Roberto, Stefansson, Kari, O'Donnell, Christopher J, Salomaa, Veikko, Rader, Daniel J, Peltonen, Leena, Schwartz, Stephen M, Altshuler, David, and Kathiresan, Sekar

Abstract

BACKGROUND: High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic confounding, and are unmodified by disease processes, mendelian randomisation can be used to test the hypothesis that the association of a plasma biomarker with disease is causal. METHODS: We performed two mendelian randomisation analyses. First, we used as an instrument a single nucleotide polymorphism (SNP) in the endothelial lipase gene (LIPG Asn396Ser) and tested this SNP in 20 studies (20,913 myocardial infarction cases, 95,407 controls). Second, we used as an instrument a genetic score consisting of 14 common SNPs that exclusively associate with HDL cholesterol and tested this score in up to 12,482 cases of myocardial infarction and 41,331 controls. As a positive control, we also tested a genetic score of 13 common SNPs exclusively associated with LDL cholesterol. FINDINGS: Carriers of the LIPG 396Ser allele (2·6% frequency) had higher HDL cholesterol (0·14 mmol/L higher, p=8×10(-13)) but similar levels of other lipid and non-lipid risk factors for myocardial infarction compared with non-carriers. This difference in HDL cholesterol is expected to decrease risk of myocardial infarction by 13% (odds ratio [OR] 0·87, 95% CI 0·84-0·91). However, we noted that the 396Ser allele was not associated with risk of myocardial infarction (OR 0·99, 95% CI 0·88-1·11, p=0·85). From observational epidemiology, an increase of 1 SD in HDL cholesterol was associated with reduced risk of myocardial infarction (OR 0·62, 95% CI 0·58-0·66). However, a 1 SD increase in HDL cholesterol due to genetic score was not associated with risk of myocardial infarction (OR 0·93, 95% CI 0·68-1·26, p=0·63). For LDL cholesterol, the estimate from observational epidemiology (a 1 SD increase in LDL cholesterol associated with OR 1·54, 95% CI 1·45-1·63) wa

Published
2012
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64. Phase II trial of erlotinib and bevacizumab in patients with advanced upper gastrointestinal cancers

Author

Rohrberg, Kristoffer S, Olesen, René K, Pfeiffer, Per, Ladekarl, Morten, Pappot, Helle, Christensen, Ib J, Høyer-Hansen, Gunilla, Sørensen, Morten, Skov, Birgit G, Buysschaert, Ian, Carmeliet, Peter, Lassen, Ulrik, Rohrberg, Kristoffer S, Olesen, René K, Pfeiffer, Per, Ladekarl, Morten, Pappot, Helle, Christensen, Ib J, Høyer-Hansen, Gunilla, Sørensen, Morten, Skov, Birgit G, Buysschaert, Ian, Carmeliet, Peter, and Lassen, Ulrik

Abstract

Patients with upper gastrointestinal cancers have a poor prognosis and only few treatment options. The epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) are valid targets in many solid tumours, and they have synergistic effects in preclinical studies.

Published
2012

65. Plasma HDL cholesterol and risk of myocardial infarction:a mendelian randomisation study

Author

Voight, Benjamin F, Peloso, Gina M, Orho-Melander, Marju, Frikke-Schmidt, Ruth, Barbalic, Maja, Jensen, Majken Karoline, Hindy, George, Hólm, Hilma, Ding, Eric L, Johnson, Toby, Schunkert, Heribert, Samani, Nilesh J, Clarke, Robert, Hopewell, Jemma C, Thompson, John F, Li, Mingyao, Thorleifsson, Gudmar, Newton-Cheh, Christopher, Musunuru, Kiran, Pirruccello, James P, Saleheen, Danish, Chen, Li, Stewart, Alexandre F R, Schillert, Arne, Thorsteinsdottir, Unnur, Thorgeirsson, Gudmundur, Anand, Sonia, Engert, James C, Morgan, Thomas, Spertus, John, Stoll, Monika, Berger, Klaus, Martinelli, Nicola, Girelli, Domenico, McKeown, Pascal P, Patterson, Christopher C, Epstein, Stephen E, Devaney, Joseph, Burnett, Mary-Susan, Mooser, Vincent, Ripatti, Samuli, Surakka, Ida, Nieminen, Markku S, Sinisalo, Juha, Lokki, Marja-Liisa, Perola, Markus, Havulinna, Aki, de Faire, Ulf, Gigante, Bruna, Ingelsson, Erik, Zeller, Tanja, Wild, Philipp, de Bakker, Paul I W, Klungel, Olaf H, Maitland-van der Zee, Anke-Hilse, Peters, Bas J M, de Boer, Anthonius, Grobbee, Diederick E, Kamphuisen, Pieter W, Deneer, Vera H M, Elbers, Clara C, Onland-Moret, N Charlotte, Hofker, Marten H, Wijmenga, Cisca, Verschuren, W M Monique, Boer, Jolanda M A, van der Schouw, Yvonne T, Rasheed, Asif, Frossard, Philippe, Demissie, Serkalem, Willer, Cristen, Do, Ron, Ordovas, Jose M, Abecasis, Gonçalo R, Boehnke, Michael, Mohlke, Karen L, Daly, Mark J, Guiducci, Candace, Burtt, Noël P, Surti, Aarti, Gonzalez, Elena, Purcell, Shaun, Gabriel, Stacey, Marrugat, Jaume, Peden, John, Erdmann, Jeanette, Diemert, Patrick, Willenborg, Christina, König, Inke R, Fischer, Marcus, Hengstenberg, Christian, Ziegler, Andreas, Buysschaert, Ian, Lambrechts, Diether, Van de Werf, Frans, Fox, Keith A, El Mokhtari, Nour Eddine, Rubin, Diana, Schrezenmeir, Jürgen, Schreiber, Stefan, Schäfer, Arne, Danesh, John, Blankenberg, Stefan, Roberts, Robert, McPherson, Ruth, Watkins, Hugh, Hall, Alistair S, Overvad, Kim, Rimm, Eric, Boerwinkle, Eric, Tybjaerg-Hansen, Anne, Cupples, L Adrienne, Reilly, Muredach P, Melander, Olle, Mannucci, Pier M, Ardissino, Diego, Siscovick, David, Elosua, Roberto, Stefansson, Kari, O'Donnell, Christopher J, Salomaa, Veikko, Rader, Daniel J, Peltonen, Leena, Schwartz, Stephen M, Altshuler, David, Kathiresan, Sekar, Voight, Benjamin F, Peloso, Gina M, Orho-Melander, Marju, Frikke-Schmidt, Ruth, Barbalic, Maja, Jensen, Majken Karoline, Hindy, George, Hólm, Hilma, Ding, Eric L, Johnson, Toby, Schunkert, Heribert, Samani, Nilesh J, Clarke, Robert, Hopewell, Jemma C, Thompson, John F, Li, Mingyao, Thorleifsson, Gudmar, Newton-Cheh, Christopher, Musunuru, Kiran, Pirruccello, James P, Saleheen, Danish, Chen, Li, Stewart, Alexandre F R, Schillert, Arne, Thorsteinsdottir, Unnur, Thorgeirsson, Gudmundur, Anand, Sonia, Engert, James C, Morgan, Thomas, Spertus, John, Stoll, Monika, Berger, Klaus, Martinelli, Nicola, Girelli, Domenico, McKeown, Pascal P, Patterson, Christopher C, Epstein, Stephen E, Devaney, Joseph, Burnett, Mary-Susan, Mooser, Vincent, Ripatti, Samuli, Surakka, Ida, Nieminen, Markku S, Sinisalo, Juha, Lokki, Marja-Liisa, Perola, Markus, Havulinna, Aki, de Faire, Ulf, Gigante, Bruna, Ingelsson, Erik, Zeller, Tanja, Wild, Philipp, de Bakker, Paul I W, Klungel, Olaf H, Maitland-van der Zee, Anke-Hilse, Peters, Bas J M, de Boer, Anthonius, Grobbee, Diederick E, Kamphuisen, Pieter W, Deneer, Vera H M, Elbers, Clara C, Onland-Moret, N Charlotte, Hofker, Marten H, Wijmenga, Cisca, Verschuren, W M Monique, Boer, Jolanda M A, van der Schouw, Yvonne T, Rasheed, Asif, Frossard, Philippe, Demissie, Serkalem, Willer, Cristen, Do, Ron, Ordovas, Jose M, Abecasis, Gonçalo R, Boehnke, Michael, Mohlke, Karen L, Daly, Mark J, Guiducci, Candace, Burtt, Noël P, Surti, Aarti, Gonzalez, Elena, Purcell, Shaun, Gabriel, Stacey, Marrugat, Jaume, Peden, John, Erdmann, Jeanette, Diemert, Patrick, Willenborg, Christina, König, Inke R, Fischer, Marcus, Hengstenberg, Christian, Ziegler, Andreas, Buysschaert, Ian, Lambrechts, Diether, Van de Werf, Frans, Fox, Keith A, El Mokhtari, Nour Eddine, Rubin, Diana, Schrezenmeir, Jürgen, Schreiber, Stefan, Schäfer, Arne, Danesh, John, Blankenberg, Stefan, Roberts, Robert, McPherson, Ruth, Watkins, Hugh, Hall, Alistair S, Overvad, Kim, Rimm, Eric, Boerwinkle, Eric, Tybjaerg-Hansen, Anne, Cupples, L Adrienne, Reilly, Muredach P, Melander, Olle, Mannucci, Pier M, Ardissino, Diego, Siscovick, David, Elosua, Roberto, Stefansson, Kari, O'Donnell, Christopher J, Salomaa, Veikko, Rader, Daniel J, Peltonen, Leena, Schwartz, Stephen M, Altshuler, David, and Kathiresan, Sekar

Abstract

High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic confounding, and are unmodified by disease processes, mendelian randomisation can be used to test the hypothesis that the association of a plasma biomarker with disease is causal.

Published
2012

66. Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease

Author

Van de Veire, Sara, Stalmans, Ingeborg, Heindryckx, Femke, Oura, Hajimu, Tijeras-Raballand, Annemilaï, Schmidt, Thomas, Loges, Sonja, Albrecht, Imke, Jonckx, Bart, Vinckier, Stefan, Van Steenkiste, Christophe, Tugues, Sònia, Rolny, Charlotte, De Mol, Maria, Dettori, Daniela, Hainaud, Patricia, Coenegrachts, Lieve, Contreres, Jean-Olivier, Van Bergen, Tine, Cuervo, Henar, Xiao, Wei-Hong, Le Henaff, Carole, Buysschaert, Ian, Kharabi Masouleh, Behzad, Geerts, Anja, Schomber, Tibor, Bonnin, Philippe, Lambert, Vincent, Haustraete, Jurgen, Zacchigna, Serena, Rakic, Jean-Marie, Jiménez, Wladimiro, Noël, Agnes, Giacca, Mauro, Colle, Isabelle, Foidart, Jean-Michel, Tobelem, Gerard, Morales-Ruiz, Manuel, Vilar, José, Maxwell, Patrick, Vinores, Stanley A., Carmeliet, Geert, Dewerchin, Mieke, Claesson-Welsh, Lena, Dupuy, Evelyne, Van Vlierberghe, Hans, Christofori, Gerhard, Mazzone, Massimiliano, Detmar, Michael, Collen, Désiré, Carmeliet, Peter, Van de Veire, Sara, Stalmans, Ingeborg, Heindryckx, Femke, Oura, Hajimu, Tijeras-Raballand, Annemilaï, Schmidt, Thomas, Loges, Sonja, Albrecht, Imke, Jonckx, Bart, Vinckier, Stefan, Van Steenkiste, Christophe, Tugues, Sònia, Rolny, Charlotte, De Mol, Maria, Dettori, Daniela, Hainaud, Patricia, Coenegrachts, Lieve, Contreres, Jean-Olivier, Van Bergen, Tine, Cuervo, Henar, Xiao, Wei-Hong, Le Henaff, Carole, Buysschaert, Ian, Kharabi Masouleh, Behzad, Geerts, Anja, Schomber, Tibor, Bonnin, Philippe, Lambert, Vincent, Haustraete, Jurgen, Zacchigna, Serena, Rakic, Jean-Marie, Jiménez, Wladimiro, Noël, Agnes, Giacca, Mauro, Colle, Isabelle, Foidart, Jean-Michel, Tobelem, Gerard, Morales-Ruiz, Manuel, Vilar, José, Maxwell, Patrick, Vinores, Stanley A., Carmeliet, Geert, Dewerchin, Mieke, Claesson-Welsh, Lena, Dupuy, Evelyne, Van Vlierberghe, Hans, Christofori, Gerhard, Mazzone, Massimiliano, Detmar, Michael, Collen, Désiré, and Carmeliet, Peter

Abstract

Our findings that PlGF is a cancer target and anti-PlGF is useful for anticancer treatment have been challenged by Bais et al. Here we take advantage of carcinogen-induced and transgenic tumor models as well as ocular neovascularization to report further evidence in support of our original findings of PlGF as a promising target for anticancer therapies. We present evidence for the efficacy of additional anti-PlGF antibodies and their ability to phenocopy genetic deficiency or silencing of PlGF in cancer and ocular disease but also show that not all anti-PlGF antibodies are effective. We also provide additional evidence for the specificity of our anti-PlGF antibody and experiments to suggest that anti-PlGF treatment will not be effective for all tumors and why. Further, we show that PlGF blockage inhibits vessel abnormalization rather than density in certain tumors while enhancing VEGF-targeted inhibition in ocular disease. Our findings warrant further testing of anti-PlGF therapies.

Published
2010
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67. Markers of angiogenesis and epidermal growth factor receptor signalling in patients with pancreatic and gastroesophageal junction cancer

Author

Rohrberg, Kristoffer Staal, Skov, Birgit Guldhammer, Lassen, Ulrik, Christensen, Ib Jarle, Høyer-Hansen, Gunilla, Buysschaert, Ian, Pappot, Helle, Rohrberg, Kristoffer Staal, Skov, Birgit Guldhammer, Lassen, Ulrik, Christensen, Ib Jarle, Høyer-Hansen, Gunilla, Buysschaert, Ian, and Pappot, Helle

Abstract

The epidermal growth factor receptor (EGFR) and angiogenesis are well established targets in anti-cancer therapy. Several targeted anti-cancer therapies are in clinical trials in pancreatic and gastroesophageal (GEJ) cancer. However, many patients do not respond to these targeted therapies and there is therefore an increasing need for biomarkers for selection of patients to these therapies. We investigated the expression of EGFR, vascular endothelial growth factor A (VEGF-A), and VEGF receptor 2 (VEGFR-2) in tumour tissue by immunohistochemistry, and soluble EGFR (sEGFR), soluble VEGFR-2 (sVEGFR-2), basic fibroblast growth factor (bFGF), placental growth factor (PlGF), plasminogen activator inhibitor 1 (PAI-1), and different forms of the urokinase plasminogen activator receptor (uPAR): uPAR (I), uPAR (I-III), and uPAR (I-III)+(II-III) in plasma by quantitative immunoassays in 14 patients with pancreatic and GEJ cancer. We found expression in tumour tissue and the plasma levels to be similar to those found in patients with other tumour types. No correlation was found between the blood levels of soluble receptors and the corresponding tumour tissue levels. We conclude that these markers are present in pancreatic and GEJ cancer patients, and could be investigated further as predictive biomarkers in such patients treated with EGFR or angiogenesis targeted therapies.

Published
2010

69. Three-year clinical results of the Axxess Biolimus A9 eluting bifurcation stent system: the DIVERGE study

Author

Buysschaert, Ian, primary, Dubois, Christophe L., additional, Dens, Joseph, additional, Ormiston, John, additional, Worthley, Stephen, additional, McClean, Dougal, additional, Ottervanger, Jan Paul, additional, Meredith, Ian, additional, Uren, Neal, additional, Wijns, William, additional, Whitbourn, Rob, additional, Mehran, Roxana, additional, Lansky, Alexandra J., additional, Bichalska, Marzena, additional, Meis, Susanne, additional, and Verheye, Stefan, additional

Published
2013
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71. Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

Author

Voight, Benjamin F, primary, Peloso, Gina M, additional, Orho-Melander, Marju, additional, Frikke-Schmidt, Ruth, additional, Barbalic, Maja, additional, Jensen, Majken K, additional, Hindy, George, additional, Hólm, Hilma, additional, Ding, Eric L, additional, Johnson, Toby, additional, Schunkert, Heribert, additional, Samani, Nilesh J, additional, Clarke, Robert, additional, Hopewell, Jemma C, additional, Thompson, John F, additional, Li, Mingyao, additional, Thorleifsson, Gudmar, additional, Newton-Cheh, Christopher, additional, Musunuru, Kiran, additional, Pirruccello, James P, additional, Saleheen, Danish, additional, Chen, Li, additional, Stewart, Alexandre FR, additional, Schillert, Arne, additional, Thorsteinsdottir, Unnur, additional, Thorgeirsson, Gudmundur, additional, Anand, Sonia, additional, Engert, James C, additional, Morgan, Thomas, additional, Spertus, John, additional, Stoll, Monika, additional, Berger, Klaus, additional, Martinelli, Nicola, additional, Girelli, Domenico, additional, McKeown, Pascal P, additional, Patterson, Christopher C, additional, Epstein, Stephen E, additional, Devaney, Joseph, additional, Burnett, Mary-Susan, additional, Mooser, Vincent, additional, Ripatti, Samuli, additional, Surakka, Ida, additional, Nieminen, Markku S, additional, Sinisalo, Juha, additional, Lokki, Marja-Liisa, additional, Perola, Markus, additional, Havulinna, Aki, additional, de Faire, Ulf, additional, Gigante, Bruna, additional, Ingelsson, Erik, additional, Zeller, Tanja, additional, Wild, Philipp, additional, de Bakker, Paul I W, additional, Klungel, Olaf H, additional, Maitland-van der Zee, Anke-Hilse, additional, Peters, Bas J M, additional, de Boer, Anthonius, additional, Grobbee, Diederick E, additional, Kamphuisen, Pieter W, additional, Deneer, Vera H M, additional, Elbers, Clara C, additional, Onland-Moret, N Charlotte, additional, Hofker, Marten H, additional, Wijmenga, Cisca, additional, Verschuren, WM Monique, additional, Boer, Jolanda MA, additional, van der Schouw, Yvonne T, additional, Rasheed, Asif, additional, Frossard, Philippe, additional, Demissie, Serkalem, additional, Willer, Cristen, additional, Do, Ron, additional, Ordovas, Jose M, additional, Abecasis, Gonçalo R, additional, Boehnke, Michael, additional, Mohlke, Karen L, additional, Daly, Mark J, additional, Guiducci, Candace, additional, Burtt, Noël P, additional, Surti, Aarti, additional, Gonzalez, Elena, additional, Purcell, Shaun, additional, Gabriel, Stacey, additional, Marrugat, Jaume, additional, Peden, John, additional, Erdmann, Jeanette, additional, Diemert, Patrick, additional, Willenborg, Christina, additional, König, Inke R, additional, Fischer, Marcus, additional, Hengstenberg, Christian, additional, Ziegler, Andreas, additional, Buysschaert, Ian, additional, Lambrechts, Diether, additional, Van de Werf, Frans, additional, Fox, Keith A, additional, El Mokhtari, Nour Eddine, additional, Rubin, Diana, additional, Schrezenmeir, Jürgen, additional, Schreiber, Stefan, additional, Schäfer, Arne, additional, Danesh, John, additional, Blankenberg, Stefan, additional, Roberts, Robert, additional, McPherson, Ruth, additional, Watkins, Hugh, additional, Hall, Alistair S, additional, Overvad, Kim, additional, Rimm, Eric, additional, Boerwinkle, Eric, additional, Tybjaerg-Hansen, Anne, additional, Cupples, L Adrienne, additional, Reilly, Muredach P, additional, Melander, Olle, additional, Mannucci, Pier M, additional, Ardissino, Diego, additional, Siscovick, David, additional, Elosua, Roberto, additional, Stefansson, Kari, additional, O'Donnell, Christopher J, additional, Salomaa, Veikko, additional, Rader, Daniel J, additional, Peltonen, Leena, additional, Schwartz, Stephen M, additional, Altshuler, David, additional, and Kathiresan, Sekar, additional

Published
2012
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74. Phase II trial of erlotinib and bevacizumab in patients with advanced upper gastrointestinal cancers

Author

Rohrberg, Kristoffer S., primary, Olesen, René K., additional, Pfeiffer, Per, additional, Ladekarl, Morten, additional, Pappot, Helle, additional, Christensen, Ib J., additional, Høyer-Hansen, Gunilla, additional, Sørensen, Morten, additional, Skov, Birgit G., additional, Buysschaert, Ian, additional, Carmeliet, Peter, additional, and Lassen, Ulrik, additional

Published
2011
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76. Neuronal FLT1 receptor and its selective ligand VEGF‐B protect against retrograde degeneration of sensory neurons

Author

Dhondt, Joke, primary, Peeraer, Eve, additional, Verheyen, An, additional, Nuydens, Rony, additional, Buysschaert, Ian, additional, Poesen, Koen, additional, Van Geyte, Katie, additional, Beerens, Manu, additional, Shibuya, Masabumi, additional, Haigh, Jody J., additional, Meert, Theo, additional, Carmeliet, Peter, additional, and Lambrechts, Diether, additional

Published
2011
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77. Abstract LB-362: PlGF inhibition phenocopies PlGF deficiency in cancer

Author

Schmidt, Thomas, primary, Van de Veire, Sara, additional, Heindryckx, Femke, additional, Oura, Hajimu, additional, Tijeras-Raballand, Annemilaï, additional, Loges, Sonja, additional, Albrecht, Imke, additional, Jonckx, Bart, additional, Vinckier, Stefan, additional, Van Steenkiste, Christophe, additional, Tugues, Sònia, additional, Rolny, Charlotte, additional, De Mol, Maria, additional, Dettori, Daniela, additional, Hainaud, Patricia, additional, Coenegrachts, Lieve, additional, Contreres, Jean-Olivier, additional, Cuervo, Henar, additional, Henaff, Carole Le, additional, Buysschaert, Ian, additional, Masouleh, Behzad Kharabi, additional, Geerts, Anja, additional, Schomber, Tibor, additional, Bonnin, Philippe, additional, Haustraete, Juergen, additional, Zacchigna, Serena, additional, Jiménez, Wladimiro, additional, Giacca, Mauro, additional, Colle, Isabelle, additional, Tobelem, Gerard, additional, Morales-Ruiz, Manuel, additional, Vilar, José, additional, Carmeliet, Geert, additional, Dewerchin, Mieke, additional, Claesson-Welsh, Lena, additional, Dupuy, Evelyne, additional, Van Vlierberghe, Hans, additional, Christofori, Gerhard, additional, Mazzone, Massimiliano, additional, Detmar, Michael, additional, Collen, Désiré, additional, and Carmeliet, Peter, additional

Published
2010
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78. Further Pharmacological and Genetic Evidence for the Efficacy of PlGF Inhibition in Cancer and Eye Disease

Author

Van de Veire, Sara, primary, Stalmans, Ingeborg, additional, Heindryckx, Femke, additional, Oura, Hajimu, additional, Tijeras-Raballand, Annemilaï, additional, Schmidt, Thomas, additional, Loges, Sonja, additional, Albrecht, Imke, additional, Jonckx, Bart, additional, Vinckier, Stefan, additional, Van Steenkiste, Christophe, additional, Tugues, Sònia, additional, Rolny, Charlotte, additional, De Mol, Maria, additional, Dettori, Daniela, additional, Hainaud, Patricia, additional, Coenegrachts, Lieve, additional, Contreres, Jean-Olivier, additional, Van Bergen, Tine, additional, Cuervo, Henar, additional, Xiao, Wei-Hong, additional, Le Henaff, Carole, additional, Buysschaert, Ian, additional, Masouleh, Behzad Kharabi, additional, Geerts, Anja, additional, Schomber, Tibor, additional, Bonnin, Philippe, additional, Lambert, Vincent, additional, Haustraete, Jurgen, additional, Zacchigna, Serena, additional, Rakic, Jean-Marie, additional, Jiménez, Wladimiro, additional, Noël, Agnes, additional, Giacca, Mauro, additional, Colle, Isabelle, additional, Foidart, Jean-Michel, additional, Tobelem, Gerard, additional, Morales-Ruiz, Manuel, additional, Vilar, José, additional, Maxwell, Patrick, additional, Vinores, Stanley A., additional, Carmeliet, Geert, additional, Dewerchin, Mieke, additional, Claesson-Welsh, Lena, additional, Dupuy, Evelyne, additional, Van Vlierberghe, Hans, additional, Christofori, Gerhard, additional, Mazzone, Massimiliano, additional, Detmar, Michael, additional, Collen, Désiré, additional, and Carmeliet, Peter, additional

Published
2010
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80. Phase II trial of erlotinib and bevacizumab in patients with advanced upper gastrointestinal cancers.

Author

Rohrberg, Kristoffer S., Olesen, René K., Pfeiffer, Per, Ladekarl, Morten, Pappot, Helle, Christensen, Ib J., Høyer-Hansen, Gunilla, Sørensen, Morten, Skov, Birgit G., Buysschaert, Ian, Carmeliet, Peter, and Lassen, Ulrik

Subjects
COMBINATION drug therapy, VASCULAR endothelial growth factor antagonists, ACADEMIC medical centers, BIOMARKERS, CANCER, CLINICAL trials, CONFIDENCE intervals, DRUG resistance in cancer cells, DOSE-effect relationship in pharmacology, DRUG toxicity, EPIDEMIOLOGY, EPIDERMAL growth factor, LONGITUDINAL method, MEDICAL cooperation, MONOCLONAL antibodies, MULTIVARIATE analysis, HEALTH outcome assessment, NEOVASCULARIZATION inhibitors, REGRESSION analysis, RESEARCH, RESEARCH funding, SURVIVAL analysis (Biometry), SURVIVAL, GASTROINTESTINAL tumors, LOGISTIC regression analysis, DATA analysis, TREATMENT effectiveness, DATA analysis software, DESCRIPTIVE statistics, KAPLAN-Meier estimator, CHEMICAL inhibitors, THERAPEUTICS
Abstract

Background. Patients with upper gastrointestinal cancers have a poor prognosis and only few treatment options. The epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) are valid targets in many solid tumours, and they have synergistic effects in preclinical studies. Methods. In this multi-center phase II trial patients with chemoresistant, metastatic upper gastrointestinal cancer were treated with erlotinib (150 mg daily) and bevacizumab (10 mg/kg every two weeks). Primary endpoint was overall response rate (ORR). Secondary endpoints were progression free survival (PFS), overall survival (OS), toxicity and biomarker correlates. Plasma samples were analysed for EGFR and angiogenesis related markers using quantitative immunoassays. Results. One hundred and two patients were enrolled in the trial between June 2006 and October 2007. The most common toxicities were skin reaction, diarrhoea, and fatigue. ORR was 6%, median PFS was 2.2 months, and OS 4.3 months. Low concentration of urokinase plasminogen activator receptor (uPAR) domain I was correlated to longer PFS and OS. Discussion. The combination of erlotinib and bevacizumab is well tolerated, however, with low clinical activity in patients with chemoresistant UGI cancer. Some patients do benefit from the therapy, and uPAR forms are potential biomarkers in these patients. [ABSTRACT FROM AUTHOR]

Published
2012
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82. Contribution of 18 fluoro-deoxyglucose positron emission tomography to the work-up of patients with fever of unknown origin.

Author

Buysschaert, Ian, Vanderschueren, Steven, Blockmans, Daniël, Mortelmans, Luc, and Knockaert, Daniël

Subjects
*POSITRONS, *POSITRON emission tomography, *DIAGNOSIS, *PATIENTS
Abstract

Background: Recent studies have suggested that 18fluoro-deoxyglucose (FDG) positron emission tomography (PET) may be useful in the work-up of patients with fever of unknown origin (FUO), but its exact diagnostic yield has not been established. Methods: From January 1999 through December 2001, 74 (67%) of 110 prospectively collected patients who fulfilled the revised criteria of classic FUO underwent a FDG-PET scan. The diagnostic yield of this technique was assessed after diagnostic work-up and follow-up. Abnormal FDG-PET scans that pointed to the final diagnosis were categorized as helpful; all other scans were considered noncontributory. Results: A final diagnosis was established in 39 (53%) of the 74 patients who underwent FDG-PET. Fifty-three (72%) of the 74 FDG-PET scans were abnormal; 19 scans (36% of the abnormal scans or 26% of the total number of scans) were helpful. In the 39 patients with a final diagnosis, 49% of the scans were helpful. A diagnosis was established in 31 (58%) of the 53 patients with an abnormal scan and in 8 (38%) of the 21 patients with a normal scan (P=0.2). Baseline clinical variables (age and sex, as well as periodicity, duration, and height of the fever) and inflammatory parameters (erythrocyte sedimentation rate, C-reactive protein, and hemoglobin) did not predict the usefulness of FDG-PET. Conclusions: FDG-PET contributed positively to the diagnosis in a quarter of our patients with classical FUO. This number is lower than that found in previous studies. Yet, against the background of the wide array of heterogeneous disorders that make up the FUO spectrum and the low number of final diagnoses established (in only 53% of cases), the diagnostic yield of FDG-PET is encouraging. Therefore, the use of FDG-PET should be considered whenever a baseline work-up fails to reveal the cause of a prolonged, febrile illness. [Copyright &y& Elsevier]

Published
2004
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83. HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF

Author

Rolny, Charlotte, Mazzone, Massimiliano, Tugues, Sònia, Laoui, Damya, Johansson, Irja, Coulon, Cathy, Squadrito, Mario Leonardo, Segura, Inmaculada, Li, Xiujuan, Knevels, Ellen, Costa, Sandra, Vinckier, Stefan, Dresselaer, Tom, Åkerud, Peter, De Mol, Maria, Salomäki, Henriikka, Phillipson, Mia, Wyns, Sabine, Larsson, Erik, Buysschaert, Ian, Botling, Johan, Himmelreich, Uwe, Ginderachter, Van, Jo, A., De Palma, Michele, Dewerchin, Mieke, Claesson-Welsh, Lena, and Carmeliet, Peter

Abstract

Polarization of tumor-associated macrophages (TAMs) to a proangiogenic/immune-suppressive (M2-like) phenotype and abnormal, hypoperfused vessels are hallmarks of malignancy, but their molecular basis and interrelationship remains enigmatic. We report that the host-produced histidine-rich glycoprotein (HRG) inhibits tumor growth and metastasis, while improving chemotherapy. By skewing TAM polarization away from the M2- to a tumor-inhibiting M1-like phenotype, HRG promotes antitumor immune responses and vessel normalization, effects known to decrease tumor growth and metastasis and to enhance chemotherapy. Skewing of TAM polarization by HRG relies substantially on downregulation of placental growth factor (PlGF). Besides unveiling an important role for TAM polarization in tumor vessel abnormalization, and its regulation by HRG/PlGF, these findings offer therapeutic opportunities for anticancer and antiangiogenic treatment.

84. Severe biventricular hypertrophy in MELAS mitochondrial disease.

Author

Debrauwere, Jan, Buysschaert, Ian, Rosseel, Liesbeth, Breckpot, Jeroen, and Seneca, Sara

Subjects
BIOPSY, MITOCHONDRIAL pathology, CHEST X rays, ELECTROCARDIOGRAPHY, CARDIAC hypertrophy, LACTATES, GENETIC mutation, SEQUENCE analysis, LEFT ventricular hypertrophy, DIAGNOSIS, GENETICS
Abstract

The article discusses the condition of a 58-year-old male with MELAS mitochondrial disease who was diagnosed with severe biventricular hypertrophy using various cardiovascular Imaging techniques.

Published
2017
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87. Complications of pulmonary vein isolation in atrial fibrillation: predictors and comparison between four different ablation techniques: Results from the MIddelheim PVI-registry.

Author

De Greef Y, Ströker E, Schwagten B, Kupics K, De Cocker J, Chierchia GB, de Asmundis C, Stockman D, and Buysschaert I

Subjects
Aged, Atrial Fibrillation diagnosis, Atrial Fibrillation epidemiology, Atrial Fibrillation physiopathology, Belgium epidemiology, Cardiac Catheters, Catheter Ablation instrumentation, Clinical Decision-Making, Comorbidity, Cryosurgery instrumentation, Electrodes, Equipment Design, Female, Humans, Male, Middle Aged, Patient Selection, Postoperative Complications diagnosis, Postoperative Complications therapy, Prevalence, Pulmonary Veins physiopathology, Registries, Risk Assessment, Risk Factors, Sex Factors, Time Factors, Treatment Outcome, Atrial Fibrillation surgery, Catheter Ablation adverse effects, Cryosurgery adverse effects, Postoperative Complications epidemiology, Pulmonary Veins surgery
Abstract

Aims: To define predictors of complications of pulmonary vein isolation (PVI) and compare safety between different ablation techniques., Methods and Results: One thousand patients with atrial fibrillation (AF) (age 60 ± 10, 72% males, CHA2DS2-VASc score 1 ± 1) underwent PVI using various techniques: conventional PVI (CPVI) using mapping with irrigated point-per-point RF ablation (n = 576), multi-electrode RF ablation with the pulmonary vein ablation catheter (PVAC) (n = 272) or high density mesh ablator (HDMA) (n = 59) and cryoballoon (CB) ablation (n = 93). A complication was defined as any procedure-related adverse event resulting in permanent injury or death, requiring intervention or treatment, or prolonging/requiring hospitalization for >48 h. A total of 105 (10.5%) complications occurred in 101 (10.1%) patients. No periprocedural death occurred. Most frequent complications were vascular complications (4%) and pericarditis (3.1%). Seven patients experienced permanent deficit due to PV stenosis (n = 3, 1 CPVI, 2 PVAC) (n = 3) and phrenic nerve palsy (PNP) (n = 4, 3 CPVI, 1 PVAC). Independent predictors of complications were female sex [odds ratio (OR) = 1.73; 95% confidence interval (CI) 1.08-2.79; P = 0.023], CHA2DS2-VASc score (OR = 1.24; 95% CI 1.01-1.52; P = 0.039), and ablation technique (P = 0.006) in multivariable-adjusted analysis. Among the different techniques, CB (P = 0.047) and PVAC ablation (P = 0.003) had lowest overall complication rates. Complication profile (type/severity) differed between techniques (association between CB and PNP, CPVI and pericardial injury, PVAC and transient ischaemic attack/PV stenosis)., Conclusion: Overall complication rate of PVI with various techniques is 10.5%. Permanent deficit occurred only after PVAC and CPVI in 0.7% of patients. Female sex and a higher CHA2DS2-VASc score increase, while PVAC and CB-PVI decrease, overall risk. Differences in overall safety and individual complication profile make selection of the ablation technique in relation to clinical risk profile possible.

Published
2018
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88. Severe biventricular hypertrophy in MELAS mitochondrial disease.

Author

Rosseel L, Breckpot J, Debrauwere J, Seneca S, and Buysschaert I

Subjects
Biopsy, Needle, Cardiomyopathy, Hypertrophic complications, Cardiomyopathy, Hypertrophic pathology, Dyspnea diagnosis, Dyspnea etiology, Echocardiography, Doppler, Electrocardiography methods, Humans, Hypertrophy, Left Ventricular diagnostic imaging, Hypertrophy, Left Ventricular pathology, Hypertrophy, Right Ventricular diagnostic imaging, Hypertrophy, Right Ventricular pathology, Immunohistochemistry, MELAS Syndrome complications, MELAS Syndrome pathology, Magnetic Resonance Imaging, Cine methods, Male, Middle Aged, Mitochondrial Diseases pathology, Prognosis, Radiography, Thoracic methods, Rare Diseases, Cardiomyopathy, Hypertrophic diagnostic imaging, MELAS Syndrome diagnostic imaging, Mitochondrial Diseases diagnostic imaging, Multimodal Imaging methods
Published
2017
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89. Iatrogenic left main coronary artery dissection and intramural hematoma caused by diagnostic transradial cardiac catheterization.

Author

Sanidas E, Buysschaert I, and van Langenhove G

Subjects
Cardiac Catheterization methods, Female, Humans, Iatrogenic Disease, Middle Aged, Radial Artery, Cardiac Catheterization adverse effects, Coronary Vessels injuries, Heart Diseases etiology, Hematoma etiology
Abstract

The growing use of the transradial approach for percutaneous coronary interventions has been shown to decrease the risk of major vascular complications. However, in this case report we describe a iatrogenic left main dissection during diagnostic coronary catheterization, which remains a rare, but still life-threatening condition. The adjunctive use of intravascular ultrasound may assist in the accurate diagnosis and treatment process.

Published
2014

90. Stone heart or apical retraction and calcification in Chagas' cardiomyopathy.

Author

Buysschaert I, De Keyser J, and Dujardin K

Subjects
Adult, Barium Sulfate, Chagas Cardiomyopathy drug therapy, Contrast Media, Coronary Angiography, Diagnosis, Differential, Echocardiography, Transesophageal, Electrocardiography, Enzyme-Linked Immunosorbent Assay, Humans, Magnetic Resonance Imaging, Male, Nitroimidazoles therapeutic use, Polymerase Chain Reaction, Radiography, Thoracic, Trypanocidal Agents therapeutic use, Chagas Cardiomyopathy diagnosis
Published
2012
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91. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.

Author

Schunkert H, König IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, Preuss M, Stewart AF, Barbalic M, Gieger C, Absher D, Aherrahrou Z, Allayee H, Altshuler D, Anand SS, Andersen K, Anderson JL, Ardissino D, Ball SG, Balmforth AJ, Barnes TA, Becker DM, Becker LC, Berger K, Bis JC, Boekholdt SM, Boerwinkle E, Braund PS, Brown MJ, Burnett MS, Buysschaert I, Carlquist JF, Chen L, Cichon S, Codd V, Davies RW, Dedoussis G, Dehghan A, Demissie S, Devaney JM, Diemert P, Do R, Doering A, Eifert S, Mokhtari NE, Ellis SG, Elosua R, Engert JC, Epstein SE, de Faire U, Fischer M, Folsom AR, Freyer J, Gigante B, Girelli D, Gretarsdottir S, Gudnason V, Gulcher JR, Halperin E, Hammond N, Hazen SL, Hofman A, Horne BD, Illig T, Iribarren C, Jones GT, Jukema JW, Kaiser MA, Kaplan LM, Kastelein JJ, Khaw KT, Knowles JW, Kolovou G, Kong A, Laaksonen R, Lambrechts D, Leander K, Lettre G, Li M, Lieb W, Loley C, Lotery AJ, Mannucci PM, Maouche S, Martinelli N, McKeown PP, Meisinger C, Meitinger T, Melander O, Merlini PA, Mooser V, Morgan T, Mühleisen TW, Muhlestein JB, Münzel T, Musunuru K, Nahrstaedt J, Nelson CP, Nöthen MM, Olivieri O, Patel RS, Patterson CC, Peters A, Peyvandi F, Qu L, Quyyumi AA, Rader DJ, Rallidis LS, Rice C, Rosendaal FR, Rubin D, Salomaa V, Sampietro ML, Sandhu MS, Schadt E, Schäfer A, Schillert A, Schreiber S, Schrezenmeir J, Schwartz SM, Siscovick DS, Sivananthan M, Sivapalaratnam S, Smith A, Smith TB, Snoep JD, Soranzo N, Spertus JA, Stark K, Stirrups K, Stoll M, Tang WH, Tennstedt S, Thorgeirsson G, Thorleifsson G, Tomaszewski M, Uitterlinden AG, van Rij AM, Voight BF, Wareham NJ, Wells GA, Wichmann HE, Wild PS, Willenborg C, Witteman JC, Wright BJ, Ye S, Zeller T, Ziegler A, Cambien F, Goodall AH, Cupples LA, Quertermous T, März W, Hengstenberg C, Blankenberg S, Ouwehand WH, Hall AS, Deloukas P, Thompson JR, Stefansson K, Roberts R, Thorsteinsdottir U, O'Donnell CJ, McPherson R, Erdmann J, and Samani NJ

Subjects
Adult, Aged, Alleles, Case-Control Studies, Coronary Artery Disease etiology, Female, Gene Frequency, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors, Coronary Artery Disease genetics
Abstract

We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 × 10⁻⁸ and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.

Published
2011
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92. Markers of angiogenesis and epidermal growth factor receptor signalling in patients with pancreatic and gastroesophageal junction cancer.

Author

Rohrberg KS, Skov BG, Lassen U, Christensen IJ, Høyer-Hansen G, Buysschaert I, and Pappot H

Subjects
Adult, Aged, Biomarkers, Tumor blood, Biomarkers, Tumor metabolism, Carcinoma blood, Carcinoma blood supply, Carcinoma metabolism, Early Detection of Cancer methods, ErbB Receptors physiology, Esophageal Neoplasms blood, Esophageal Neoplasms blood supply, Esophageal Neoplasms metabolism, Female, Gastrointestinal Neoplasms blood, Gastrointestinal Neoplasms blood supply, Gastrointestinal Neoplasms metabolism, Humans, Male, Middle Aged, Pancreatic Neoplasms blood, Pancreatic Neoplasms blood supply, Pancreatic Neoplasms metabolism, Prognosis, Signal Transduction, Biomarkers, Tumor analysis, Carcinoma diagnosis, ErbB Receptors metabolism, Esophageal Neoplasms diagnosis, Gastrointestinal Neoplasms diagnosis, Neovascularization, Pathologic metabolism, Pancreatic Neoplasms diagnosis
Abstract

The epidermal growth factor receptor (EGFR) and angiogenesis are well established targets in anti-cancer therapy. Several targeted anti-cancer therapies are in clinical trials in pancreatic and gastroesophageal (GEJ) cancer. However, many patients do not respond to these targeted therapies and there is therefore an increasing need for biomarkers for selection of patients to these therapies. We investigated the expression of EGFR, vascular endothelial growth factor A (VEGF-A), and VEGF receptor 2 (VEGFR-2) in tumour tissue by immunohistochemistry, and soluble EGFR (sEGFR), soluble VEGFR-2 (sVEGFR-2), basic fibroblast growth factor (bFGF), placental growth factor (PlGF), plasminogen activator inhibitor 1 (PAI-1), and different forms of the urokinase plasminogen activator receptor (uPAR): uPAR (I), uPAR (I-III), and uPAR (I-III)+(II-III) in plasma by quantitative immunoassays in 14 patients with pancreatic and GEJ cancer. We found expression in tumour tissue and the plasma levels to be similar to those found in patients with other tumour types. No correlation was found between the blood levels of soluble receptors and the corresponding tumour tissue levels. We conclude that these markers are present in pancreatic and GEJ cancer patients, and could be investigated further as predictive biomarkers in such patients treated with EGFR or angiogenesis targeted therapies.

Published
2010
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