51. Design and Rapid Fabrication of a Microfluidic Fraction Collector
- Author
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Bozhi Yang, George C. Lopez, Qiao Lin, and Alan J. Rosenbloom
- Subjects
Fabrication ,Materials science ,Constant flow ,business.industry ,Applied Mathematics ,Microfluidics ,Computational Mechanics ,Process (computing) ,General Physics and Astronomy ,Statistical and Nonlinear Physics ,Fraction Collector ,Surface tension ,Mechanics of Materials ,Modeling and Simulation ,Microfluidic channel ,Optoelectronics ,business ,Engineering (miscellaneous) ,Microscale chemistry - Abstract
This paper presents a novel microfluidic fraction collector that directs a liquid to fill a set of collection chambers in a predetermined sequence. All microfluidic channels and liquid chambers are fabricated on a flat PDMS sheet. The device exploits surface tension effects at the microscale and uses no moving parts. The filling process can be completed with low driving pressures, which are below 1400 Pa for a constant flow rate of 1 μl/min. Cross-diffusion between the individual collection chambers during the filling process is also estimated for various device geometries using typical parameters, and is shown to be generally negligible.
- Published
- 2002
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