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58. Disminución en la incidencia de la cefalea pospunción lumbar tras la aplicación de la segunda edición de la Sociedad Internacional de Cefaleas

Author

de León-Belmar J, Navarro-Gutierrez S, Herráiz-de Castro C, Montero-López L, Liaño-Martínez H, and González-Martínez F

Subjects
business.industry, Medicine, Neurology (clinical), General Medicine, business, Humanities, Post-Lumbar Puncture Headache
Abstract

Introduccion. La Sociedad Internacional de Cefaleas (IHS, International Headache Society) publico en 1988 la 1.a edicion de la clasificacion de las cefaleas. La 2.a edicion se completa en el 2003. Objetivo. Determinar si existen cambios en la incidencia de la cefalea pospuncion lumbar segun la edicion de la IHS. Pacientes y metodos. Prospectivamente se recogieron, entre el 2002 y 2003, 78 pacientes a los que se realizo una puncion lumbar diagnostica, 40 raquianestesias obstetricas y 516 raquianestesias no obstetricas. Se utilizo la 1.a edicion, y tras la aparicion de la 2.a se recodificaron los casos. Resultados. Con la 1.a edicion, la cefalea pospuncion en las punciones diagnosticas fueron 31 de 78 casos (39,7%), y cuando se utilizo la 2.a fueron 10 casos (12,8%). En las pacientes de raquianestesia obstetrica, con la utilizacion de la 1.a edicion, la incidencia de cefalea fue de seis casos de 40 (15%) y cuatro casos con la 2.a (10%). De los pacientes con raquianestesia no obstetrica la incidencia de cefalea fue de 80 (15,5%) de 516 casos con la 1.a edicion de la IHS, y 25 casos (4,85%) con la 2.a. Conclusiones. Se necesita conocer la edicion si se quieren comparar incidencias de cefalea pospuncion entre observadores, ya que las diferencias son ostensibles entre utilizar una u otra edicion. El principal motivo de discrepancia entre las dos ediciones es la asociacion obligada de algun signo acompanante, ya que este no era criterio necesario en la 1.a edicion y si en la 2.a.

Published
2005

84. Prenatal malnutrition-induced functional alterations in callosal connections and in interhemispheric asymmetry in rats are prevented by reduction of noradrenaline synthesis during gestation.

Author

Soto-Moyano, R, Alarcon, S, Hernández, A, Pérez, H, Ruiz, S, Carreño, P, Kusch, C, and Belmar, J

Subjects
BRAIN metabolism, ANIMAL experimentation, COMPARATIVE studies, ELECTRIC stimulation, ENZYME inhibitors, RESEARCH methodology, MEDICAL cooperation, NORADRENALINE, NUTRITION disorders, OCCIPITAL lobe, OXIDOREDUCTASES, PREGNANCY complications, RATS, RESEARCH, TYROSINE, VISUAL evoked response, WEIGHT gain, EVALUATION research, PRENATAL exposure delayed effects, CHEMICAL inhibitors, PHARMACODYNAMICS
Abstract

Prenatal malnutrition results in increased concentration and release of central noradrenaline, a neurotransmitter that is an important regulator of normal regressive events such as axonal pruning and synaptic elimination. This suggests that some of the functional disturbances in brain induced by prenatal malnutrition could be due at least in part to increased noradrenaline activity that may enhance regressive events during early stages of development. To test this hypothesis we studied whether chronic administration of alpha-methyl-p-tyrosine, an inhibitor of tyrosine hydroxylase, to rats during gestation might prevent long-term deleterious effects of prenatal malnutrition on functional properties of interhemispheric connections of the visual cortex, and on asymmetry of visual evoked responses. The experiments were conducted on normal and malnourished rats 45-50 d of age. Prenatal malnutrition was induced by restricting the food consumption of pregnant rats to 40%, from d 8 postconception to parturition. At birth, prenatally malnourished rats had significantly greater whole-brain noradrenaline concentration as well as significantly enhanced noradrenaline release in the visual cortex. At 45-50 d of age, the malnourished group had a significantly smaller cortical area, exhibiting transcallosal evoked responses; in addition, the amplitude of these responses was significantly smaller. Malnourished rats showed a significant reduction of the normal interhemispheric asymmetry of visual evoked responses. The addition of 0.3% alpha-methyl-p-tyrosine to the diet of malnourished pregnant rats during the last 2 wk of gestation prevented functional disorders induced in the offspring by prenatal malnutrition on interhemispheric connectivity of visual areas and on interhemispheric bioelectrical asymmetry, probably by reducing the elevated brain noradrenaline activity and thereby restoring the normal trophic role of this neurotransmitter. [ABSTRACT FROM AUTHOR]

Published
1998
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87. Trastornos electrocardiográficos asociados a epilepsia de reciente comienzo.

Author

González Martínez, F., Navarro Gutiérrez, S., De León Belmar, J. J., and Valero Serrano, B.

Subjects
CORONARY disease, EPILEPSY, SPASMS, OLDER men, PEOPLE with epilepsy
Abstract

Copyright of Neurologia (Grupo ARS XXI de Comunicacion, S.A.) is the property of Grupo ARS XXI de Comunicacion, S.A. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2005

100. Hypertensive Effects of Bradykinin in Rats

Author

H.D. Croxatto and Belmar J

Subjects
medicine.medical_specialty, Multidisciplinary, Bradykinin, Blood Pressure, Blood Pressure Determination, Vasodilation, Rats, chemistry.chemical_compound, Endocrinology, Blood pressure, chemistry, Internal medicine, Hypertension, Pressure, medicine, Animals, Kallikreins, Acetylcholine, medicine.drug
Abstract

BRADYKININ obtained from ox plasma1 and synthetic bradykinin cause intense vasodilatation in many mammalian species. Intravenous injections of bradykinin lower arterial blood pressure in anaesthetized animals. On a molar basis, bradykinin is only ten times less active than acetylcholine and as active as histamine1. Two crude bradykinin-containing extracts from ox plasma—one prepared by us and the other kindly supplied by Prof. Rocha e Silva—were shown to have the typical depressor action in normal rats, but frequently produced a striking hypertensive effect in rats nephrectomized 16–24 hr. before. These results are similar to those obtained with anephrotensin prepared from rat serum2.

Published
1961

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