51. Enhancement of memories by systemic administration of insulin-like growth factor II.
- Author
-
Stern SA, Kohtz AS, Pollonini G, and Alberini CM
- Subjects
- Animals, Brain drug effects, Brain physiology, Conditioning, Psychological drug effects, Conditioning, Psychological physiology, Fear drug effects, Fear physiology, Genes, Immediate-Early drug effects, Genes, Immediate-Early physiology, Insulin-Like Growth Factor II adverse effects, Learning drug effects, Learning physiology, Male, Memory, Long-Term physiology, Memory, Short-Term physiology, Mice, Inbred C57BL, Nootropic Agents adverse effects, Receptor, IGF Type 2 metabolism, Recognition, Psychology drug effects, Recognition, Psychology physiology, Recombinant Proteins adverse effects, Recombinant Proteins pharmacology, Social Perception, Spatial Memory drug effects, Spatial Memory physiology, Insulin-Like Growth Factor II pharmacology, Memory, Long-Term drug effects, Memory, Short-Term drug effects, Nootropic Agents pharmacology
- Abstract
To treat cognitive disorders in humans, new effective therapies that can be easily delivered systemically are needed. Previous studies showed that a bilateral injection of insulin-like growth factor II (IGF-II) into the dorsal hippocampus of rats or mice enhances fear memories and facilitates fear extinction. Here, we report that, in mice, systemic treatments with IGF-II given before training significantly enhance the retention and persistence of several types of working, short-term and long-term memories, including fear conditioning, object recognition, object placement, social recognition, and spatial reference memory. IGF-II-mediated memory enhancement does not alter memory flexibility or the ability for new learning and also occurs when IGF-II treatment is given in concert with memory retrieval. Thus IGF-II may represent a potentially important and effective treatment for enhancing human cognitive and executive functions.
- Published
- 2014
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