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Fornix-dependent induction of hippocampal CCAAT enhancer-binding protein [beta] and [delta] Co-localizes with phosphorylated cAMP response element-binding protein and accompanies long-term memory consolidation.
- Source :
-
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2001 Jan 01; Vol. 21 (1), pp. 84-91. - Publication Year :
- 2001
-
Abstract
- The cAMP response element-binding protein (CREB) is an evolutionarily conserved transcription regulator essential for long-term memory formation. It is not known, however, whether the molecular events downstream of CREB activation are also conserved. An early, cAMP-dependent event necessary for learning-related long-term synaptic plasticity in the invertebrate Aplysia californica is the induction of the transcription factor CCAAT enhancer-binding protein (C/EBP). Here we show that two homologs in the rat, C/EBPbeta and C/EBPdelta, are induced at discrete times after inhibitory avoidance learning and co-localize with phosphorylated CREB in the hippocampus. This induction is blocked by fornix lesions, which are known to disrupt activation of CREB in the hippocampus and to impair memory consolidation. These results indicate that C/EBPs are evolutionarily conserved components of the CREB-dependent gene cascade activated in long-term memory.
- Subjects :
- Animals
Avoidance Learning physiology
Behavior, Animal physiology
CCAAT-Enhancer-Binding Protein-beta biosynthesis
CCAAT-Enhancer-Binding Protein-delta
CCAAT-Enhancer-Binding Proteins genetics
Electroshock
Fornix, Brain surgery
Hippocampus cytology
Immunohistochemistry
Neural Inhibition physiology
Neurons cytology
Neurons metabolism
Phosphorylation
RNA, Messenger metabolism
Rats
Rats, Long-Evans
CCAAT-Enhancer-Binding Proteins biosynthesis
Cyclic AMP Response Element-Binding Protein metabolism
Fornix, Brain metabolism
Hippocampus metabolism
Memory physiology
Transcription Factors
Subjects
Details
- Language :
- English
- ISSN :
- 1529-2401
- Volume :
- 21
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 11150323