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52. Assessment of Opioid Use and Analgesic Requirements After Endoscopic Sinus Surgery

Author

Ayoub, Noel F., primary, Choby, Garret, additional, Turner, Justin H., additional, Abuzeid, Waleed M., additional, Raviv, Joseph R., additional, Thamboo, Andrew, additional, Ma, Yifei, additional, Chandra, Rakesh K., additional, Chowdhury, Naweed I., additional, Stokken, Janalee K., additional, O’Brien, Erin K., additional, Shah, Sharan, additional, Akbar, Nadeem, additional, Roozdar, Pooya, additional, Nayak, Jayakar V., additional, Patel, Zara M., additional, and Hwang, Peter H., additional

Published
2021
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55. Molecular disruption of RAD50 sensitizes human tumor cells to cisplatin-based chemotherapy

Author

Abuzeid, Waleed M., Jiang, Xiaoling, Shi, Guoli, Wang, Hui, Paulson, David, Araki, Koji, Jungreis, David, Carney, James, O'Malley, Bert W., Jr., and Li, Daqing

Subjects
Cancer -- Drug therapy, Cancer -- Research, DNA damage -- Causes of, DNA damage -- Research, Drug resistance -- Health aspects, Drug resistance -- Research, Platinum compounds -- Usage, Platinum compounds -- Health aspects
Abstract

Platinum-based drugs that induce DNA damage are commonly used first-line chemotherapy agents for testicular, bladder, head and neck, lung, esophageal, stomach, and ovarian cancers. The inherent resistance of tumors to DNA damage often limits the therapeutic efficacy of these agents, such as cisplatin. An enhanced DNA repair and telomere maintenance response by the Mre11/Rad50/Nbs1 (MRN) complex is critical in driving this chemoresistance. We hypothesized therefore that the targeted impairment of native cellular MRN function could sensitize tumor cells to cisplatin. To test this, we designed what we believe to be a novel dominant-negative adenoviral vector containing a mutant RAD50 gene that significantly downregulated MRN expression and markedly disrupted MRN function in human squamous cell carcinoma cells. A combination of cisplatin and mutant RAD50 therapy produced significant tumor cytotoxicity in vitro, with a corresponding increase in DNA damage and telomere shortening. In cisplatin-resistant human squamous cell cancer xenografts in nude mice, this combination therapy caused dramatic tumor regression with increased apoptosis. Our findings suggest the use of targeted RAD50 disruption as what we believe to be a novel chemosensitizing approach for cancer therapy in the context of chemoresistance. This strategy is potentially applicable to several types of malignant tumors that demonstrate chemoresistance and may positively impact the treatment of these patients., Introduction Platinum-based agents are the mainstay of chemotherapy for several tumor types, including ovarian, bladder, lung, and cancers of the head and neck (1). Cisplatin cytotoxicity results from the formation [...]

Published
2009
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56. Surgical approach is associated with complication rate in sinonasal malignancy: A multicenter study

Author

Beswick, Daniel M., primary, Hwang, Peter H., additional, Adappa, Nithin D., additional, Le, Christopher H., additional, Humphreys DO, Ian M., additional, Getz, Anne E., additional, Suh, Jeffrey D., additional, Aasen, Davis M., additional, Abuzeid, Waleed M., additional, Chang, Eugene H., additional, Kaizer, Alexander M., additional, Kindgom, Todd T., additional, Kohanski, Michael A., additional, Nabavizadeh, Seyed Ali, additional, Nayak, Jayakar V., additional, Palmer, James N., additional, Patel, Zara M., additional, Ramakrishnan, Vijay R., additional, Snyderman, Carl H., additional, St. John, Maie A., additional, Wild, Jessica, additional, and Wang, Eric W., additional

Published
2021
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57. Endoscopic Paramaxillary Approach to the Infratemporal Fossa and Pterygomaxillary Space: Computer Modeling Analysis and Clinical Series.

Author

Konuthula, Neeraja, Abuzeid, Waleed M., Humphreys, Ian M., Bly, Randall A., and Moe, Kris

Subjects
*COMPUTER simulation, *SURGICAL excision, *MANDIBULAR condyle, *MAXILLA, *EXPERIMENTAL design
Abstract

Objective  Several different open and endoscopic approaches for the pterygomaxillary space and infratemporal fossa have been described. Limitations to these approaches include restricted exposure of the infratemporal fossa and difficult surgical manipulation. Study Design  Consecutive clinical cases utilizing a novel approach to access lesions in the infratemporal fossa and pterygomaxillary space were reviewed. Data was collected on pathology, lesion location, and surgical approach(es) performed. Computer modeling was performed to analyze the full extent of surgical access provided by the paramaxillary approach to the range of target locations. Results  Ten consecutive cases met inclusion criteria. Surgical access to the target lesion was achieved in all cases. Computer modeling of the approach derived the anatomical boundaries of the paramaxillary approach. Wide access to the posterior maxilla, and lateral or medial to the mandibular condyle allows for variability in endoscopic angles and access to more medial pterygomaxillary space lesions. The lateral extent is limited proximally only by the extent of cheek/soft tissue retraction and by the zygomatic arch more superiorly. The superior limit of dissection is at the temporal line. Conclusion  The endoscopic paramaxillary approach is a transoral minimally disruptive approach to the ITF and PS that provides excellent surgical exposure for resection of lesions involving these areas. Compared with previously described endoscopic approaches, there are no external incisions; tumor manipulation is straightforward without angled endoscopy, and all areas of the infratemporal fossa and pterygomaxillary space can be accessed. [ABSTRACT FROM AUTHOR]

Published
2022
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58. Initial Presentation of Granulomatosis with Polyangiitis as Progressive Skull Base Osteomyelitis.

Author

Qureshi, Hannan A., Bandhlish, Anshu, DeConde, Robert P., Humphreys, Ian M., Abuzeid, Waleed M., and Jafari, Aria

Subjects
GRANULOMATOSIS with polyangiitis, SKULL base, OSTEOMYELITIS, MAGNETIC resonance imaging, POLYARTERITIS nodosa, ENDOSCOPIC surgery
Abstract

A healthy man in his 30s presented with a 2-week history of severe bitemporal pain and pressure. He was initially treated for presumed acute rhinosinusitis, but his symptoms continued to worsen and underwent endoscopic sinus surgery at an outside community facility. He developed left abducens nerve palsy postoperatively, and magnetic resonance imaging (MRI) demonstrated evidence of extensive skull base osteomyelitis. He was initiated on intravenous (IV) broad-spectrum antibiotics but was subsequently found to have prostatic and submandibular sterile fluid collections. The patient subsequently developed new right abducens and left vagal nerve palsies and underwent revision endoscopic sinus surgery. Pathology revealed extensive inflammation, necrotizing granulomas, and evidence of small and medium vessel vasculitis. Extensive laboratory workup was negative, except for anti-PR-3 antibody positivity. Given the characteristic findings on pathology and laboratory findings, the patient was diagnosed with granulomatosis with polyangiitis (GPA). High-dose glucocorticoid therapy as well as rituximab infusion were promptly initiated. He had marked improvement in his symptoms and resolution of his right CN VI palsy but left-sided CN VI and CN X palsies persisted. This patient presented without the typical rhinologic manifestations of GPA, and rather presented with progressive sinusitis, skull base osteomyelitis with associated cranial neuropathies, and aseptic systemic abscesses. Prompt diagnosis of GPA is particularly important in those with otorhinolaryngological manifestations, as early initial immunosuppressive therapy has been linked to lower relapse and mortality rates. Vigilance and early differentiation between GPA and other forms of sinusitis is of critical importance, particularly when symptoms are refractory to standard rhinosinusitis therapies. [ABSTRACT FROM AUTHOR]

Published
2022
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62. Semiautomated Method for Editing Surgical Videos

Author

Adidharma, Lingga, additional, Yang, Zixin, additional, Young, Christopher, additional, Li, Yangming, additional, Hannaford, Blake, additional, Humphreys, Ian, additional, Abuzeid, Waleed M., additional, Ferreira, Manuel, additional, Moe, Kristen S., additional, and Bly, Randall A., additional

Published
2021
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65. Contributors

Author

Abuzeid, Waleed M., primary, Adams, Meredith E., additional, Adamson, Peter A., additional, Adenis, Antoine, additional, Akst, Seth, additional, Albers, Sheri L., additional, Albert, David, additional, Alexander, Ronda E., additional, Archbold, Sue, additional, Armstrong, William B., additional, Arriaga, Moisés A., additional, Arts, H. Alexander, additional, Ashram, Yasmine A., additional, Aviv, Jonathan E., additional, Aygun, Nafi, additional, Backous, Douglas D., additional, Baker, Shan R., additional, Balkany, Thomas J., additional, Baloh, Robert W., additional, Barkmeier-Kraemer, Julie, additional, Baroody, Fuad M., additional, Bartlett, Nancy L., additional, Baskin, Jonathan Z., additional, Bastian, Robert W., additional, Bauer, Carol A., additional, Benninger, Michael S., additional, Bhama, Prabhat K., additional, Bhatti, Nasir Islam, additional, Blitzer, Andrew, additional, Boardman, Simone, additional, Boss, Emily F., additional, Brackmann, Derald E., additional, Bradford, Carol R., additional, Branstetter, Barton F., additional, Braun, Edward B., additional, Briggs, Robert J.S., additional, Brodie, Hilary A., additional, Brown, Carolyn J., additional, Brown, David J., additional, Brown, Kevin D., additional, Browne, J. Dale, additional, Buatti, John M., additional, Buchmann, Luke, additional, Byrne, Patrick J., additional, Galzada, Gabriel G., additional, Carey, John P., additional, Casselbrant, Margaretha L., additional, Castelnuovo, Paolo, additional, Chang, Steven, additional, Chegar, Burke E., additional, Chen, Amy, additional, Chen, Eunice Y., additional, Chen, Theodore, additional, Chepeha, Douglas B., additional, Cheuk, Alice, additional, Chheda, Neil N., additional, Chien, Wade, additional, Choi, Sukgi S., additional, Chole, Richard A., additional, Christian, James M., additional, Chu, Eugene A., additional, Citardi, Martin J., additional, Cohen, Marc A., additional, Collins, Savita, additional, Collop, Nancy A., additional, Contencin, Philippe, additional, Cook, Raymond, additional, Corey, Jacquelynne, additional, Cotton, Robin T., additional, Couch, Marion Everett, additional, Courey, Mark S., additional, Crane, Benjamin T., additional, Crumley, Roger L., additional, Cruz, Oswaldo Laércio M., additional, Culicchia, Frank, additional, Cummings, Charles W., additional, Cunningham, Calhoun D., additional, Davis, Greg E., additional, Davis, Larry E., additional, Day, Terry A., additional, De la Cruz, Antonio, additional, Santina, Charles C. Della, additional, Denlinger, Chadrick, additional, Derkay, Craig S., additional, Diaz, Rodney C., additional, Dobie, Robert A., additional, Galli, Suzanne K. Doud, additional, Duncan, Newton O., additional, Eggers, Scott D.Z., additional, Eisbruch, Avraham, additional, Eisele, David W., additional, El-Kashlan, Hussam K., additional, Elluru, Ravindhra G., additional, Ende, Kevin H., additional, Erman, Audrey B., additional, Fakhri, Samer, additional, Fakhry, Carole, additional, Farrior, Edward H., additional, Farrior, Richard T., additional, Faust, Russell A., additional, Ferguson, Berrylin J., additional, Flint, Paul W., additional, Francis, Howard W., additional, Fried, Marvin P., additional, Friedland, David R., additional, Friedman, Oren, additional, Frodel, John L., additional, Funk, Gerry F., additional, Gantz, Bruce J., additional, Garrett, C. Gaelyn, additional, Gartner-Schmidt, Jackie, additional, Gay, William Donald, additional, Ge, Norman N., additional, Gillespie, M. Boyd, additional, Girod, Douglas A., additional, Goding, George S., additional, Goldberg, Andrew N., additional, Goldenberg, David, additional, Graney, Daniel O., additional, Grant, Nazaneen N., additional, Grégoire, Vincent, additional, Gries, Heike, additional, Gubbels, Samuel P., additional, Guss, Joel, additional, Ha, Patrick, additional, Hamilton, Grant S., additional, Hanna, Ehab Y., additional, Harker, Lee A., additional, Harréus, Uli, additional, Harrison, Robert V., additional, Haughey, Bruce H., additional, Hellstein, John W., additional, Herzer, Kurt, additional, Hildebrand, Michael S., additional, Hilgers, Frans J.M., additional, Hill, Justin D., additional, Hinni, Michael L., additional, Hoffman, Henry T., additional, Holbrook, Eric H., additional, Holinger, Lauren D., additional, Holzapfel, Allison MacGregor, additional, Hom, David B., additional, House, John W., additional, House, Joyce Colton, additional, Hullar, Timothy E., additional, Husein, Murad, additional, Ing, Steven, additional, Iseli, Tim A., additional, Ishman, Stacey, additional, Jackler, Robert K., additional, Jameson, Brian, additional, Jenkins, Herman A., additional, Jin, Hong-Ryol, additional, Joe, John K., additional, Joe, Stephanie A., additional, Johnson, Gary, additional, Johnson, Rhonda, additional, Johnson, Tiffany A., additional, Johnson, Timothy M., additional, Jones, Nick S., additional, Kabaker, Sheldon S., additional, Karnell, Lucy H., additional, Kashima, Matthew L., additional, Kellman, Robert M., additional, Kelly, Paul E., additional, Kennedy, David W., additional, Khalid, Ayesha N., additional, Kies, Merrill S., additional, Kileny, Paul R., additional, Kim, David W., additional, Kim, Jason H., additional, Kim, Theresa B., additional, Kimberling, William J., additional, Koh, Jeffrey, additional, Kokot, Niels, additional, Koltai, Peter J., additional, Kozak, Frederick K., additional, Krakovitz, Paul R., additional, Kridel, Russell W.H., additional, Kumar, Parvesh, additional, Kunduk, Melda, additional, Laccourreye, Ollivier, additional, Lacey, JoAnne, additional, Lai, Stephen Y., additional, Lal, Devyani, additional, Lalwani, Anil K., additional, Lambert, Paul R., additional, Lassig, Amy Anne, additional, Latchaw, Richard E., additional, Leahy, Kevin P., additional, Lee, Daniel J., additional, Lee, Ken K., additional, Lee, Nancy, additional, Lefebvre, Jean-Louis, additional, Lefton-Greif, Maureen A., additional, Leopold, Donald A., additional, Lewis, James S., additional, Li, Daqing, additional, Lian, Timothy S., additional, Licameli, Greg R., additional, Limb, Charles J., additional, Logemann, Jeri A., additional, Loh, Thomas, additional, Lonsbury-Martin, Brenda L., additional, Lopez, Manuel A., additional, Lusk, Rodney P., additional, Lustig, Lawrence R., additional, Lysakowski, Anna, additional, MacArthur, Carol J., additional, Maisel, Robert H., additional, Malone, James P., additional, Mandel, Ellen M., additional, Mandel, Susan J., additional, Manning, Scott C., additional, Mark, Lynette, additional, Markt, Jeffery C., additional, Marsh, Michael, additional, Martin, Glen K., additional, Mattox, Douglas E., additional, McCaffrey, Thomas V., additional, McCulloch, Timothy M., additional, McGee, JoAnn, additional, McGuire, John F., additional, McJunkin, Jonathan, additional, McMurray, J. Scott, additional, Merati, Albert L., additional, Merchant, Saumil N., additional, Messner, Anna H., additional, Michelson, James, additional, Milczuk, Henry A., additional, Minor, Lloyd B., additional, Mobley, Steven Ross, additional, Muntz, Harlan, additional, Murakami, Craig S., additional, Myer, Charles M., additional, Naclerio, Robert M., additional, Nadol, Joseph B., additional, Nassif, Paul S., additional, Nedzelski, Julian, additional, Nicolai, Piero, additional, Nielsen, David R., additional, Niparko, John K., additional, Norton, Susan J., additional, Nouraei, S.A. Reza, additional, Nuss, Daniel W., additional, Nussenbaum, Brian, additional, Odland, Rick M., additional, O'Donoghue, Gerard, additional, Oliver, Eric R., additional, O’Malley, Bert W., additional, O’Reilly, Robert C., additional, Ospina, Juan Camilo, additional, Ossoff, Robert H., additional, Otto, Kristen J., additional, Packer, Mark D., additional, Pallanch, John, additional, Palmer, James N., additional, Park, Stephen S., additional, Patel, Sundip, additional, Patterson, G. Alexander, additional, Pearson, Bruce W., additional, Pellitteri, Phillip K., additional, Perkins, Jonathan A., additional, Perkins, Stephen W., additional, Pero, Colin D., additional, Pignatari, Shirley S.N., additional, Pletcher, Steven D., additional, Popovtzer, Aron, additional, Postma, Gregory N., additional, Potsic, William P., additional, Poznanovic, Sheri A., additional, Quatela, Vito C., additional, Rabinov, C. Rose, additional, Ramachandran, Virginia, additional, Randolph, Gregory W., additional, Rassekh, Christopher H., additional, Rauch, Steven D., additional, Reinisch, Lou, additional, Richardson, Mark, A., additional, Richter, Gresham T., additional, Ridgway, James M., additional, Robbins, K. Thomas, additional, Roediger, Frederick C., additional, Rogers, Jeremy, additional, Ronen, Ohad, additional, Rosenfeld, Richard M., additional, Rotter, Bruce E., additional, Rubinstein, Jay T., additional, Ruckenstein, Michael J., additional, Rumboldt, Zoran, additional, Runge-Samuelson, Christina L., additional, Rybak, Leonard P., additional, Sadoughi, Babak, additional, Salassa, John R., additional, Salinas, Thomas J., additional, Samant, Sandeep, additional, Samlan, Robin A., additional, Samy, Ravi N., additional, Sandel, Henry D., additional, Sandhu, Guri S., additional, Sando, Isamu, additional, Sauder, Cara, additional, Scarlett, Jeremy A., additional, Scher, Richard L., additional, Schessel, David A., additional, Schmalbach, Cecelia E., additional, Schwedt, Todd J., additional, Sciubba, James J., additional, Sequeira, Sunitha, additional, Seshamani, Meena, additional, Shelton, Clough, additional, Shepard, Neil T., additional, Ship, Jonathan A., additional, Shirley, W. Peyton, additional, Shnayder, Yelizaveta, additional, Shvidler, Joseph, additional, Sie, Kathleen C.Y., additional, Simmen, Daniel B., additional, Smith, Marshall E., additional, Smith, Richard J.H., additional, Sofferman, Robert A., additional, Soma, Marlene, additional, Stach, Brad A., additional, Staecker, Hinrich, additional, Stamm, Aldo Cassol, additional, Stankiewicz, James A., additional, Stavinoha, Rose, additional, Sterni, Laura M., additional, Steward, David L., additional, Stocks, Rose Mary S., additional, Sudhoff, Holger H., additional, Sunwoo, John B., additional, Swanson, Neil A., additional, Swanson, Veronica C., additional, Swarm, Robert A., additional, Sykes, Jonathan M., additional, Tan, Luke, additional, Tardy, M. Eugene, additional, Tatum, Sherard A., additional, Taylor, S. Mark, additional, Teissier, Natacha, additional, Telian, Steven A., additional, Terris, David J., additional, Teufert, Karen B., additional, Thomas, J. Regan, additional, Thompson, James N., additional, Toriumi, Dean M., additional, Torres, Alejandro I., additional, Travers, Joseph B., additional, Travers, Susan P., additional, Tsue, Terance T., additional, Tufano, Ralph P., additional, Tunkel, David E., additional, Turner, Michael D., additional, Uppaluri, Ravindra, additional, Vaezi, Michael F., additional, Van den Abbeele, Thierry, additional, van den Brekel, Michiel W.M., additional, Vaysberg, Mikhail, additional, Vokes, David E., additional, Wackym, P. Ashley, additional, Wakefield, Tamekia L., additional, Walner, David L., additional, Walsh, Edward J., additional, Walvekar, Rohan R., additional, Wang, Tom D., additional, Warren, Frank M., additional, Weber, Randal S., additional, Wein, Richard O., additional, Weinstein, Gregory S., additional, Weitzel, Erik Kent, additional, Welling, D. Bradley, additional, Wemer, Richard D., additional, Wetmore, Ralph F., additional, Weymuller, Ernest A., additional, Wiatrak, Brian J., additional, Wiet, Gregory J., additional, Wiggins, Richard H., additional, Willey, Andrea, additional, William, William N., additional, Williams, Glenn B., additional, Wippold, Franz J., additional, Woodson, Gayle Ellen, additional, Woolley, Audie L., additional, Wootten, Christopher T., additional, Wormald, Peter-John, additional, Yingling, Charles D., additional, Yueh, Bevan, additional, Yung, Rex C., additional, Zaldívar, Renzo A., additional, Zalzal, George H., additional, Zee, David S., additional, Zimbler, Marc S., additional, Zinreich, S. James, additional, and Zwolan, Teresa A., additional

Published
2010
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67. Antibiotic Use in Lateral Skull Base Surgery: A Survey of the North American Skull Base Society.

Author

Li, Kevin L., Fang, Christina H., Hawn, Vivian S., Agarwal, Vijay, Kshretty, Varun R., Bellile, Emily, Akbar, Nadeem A., McKean, Erin L., Abuzeid, Waleed M., and Moskowitz, Howard S.

Subjects
SKULL surgery, CEREBROSPINAL fluid leak, ANTIBIOTICS, SKULL base, TRAINING of surgeons, BIVARIATE analysis
Abstract

Objectives  Antibiotic use in lateral skull base surgery (LSBS) has not been thoroughly investigated in the literature. There is wide variability in antibiotic use and insufficient data to guide management. This study aims to describe the factors and patterns influencing antibiotic use in LSBS among the membership of the North American Skull Base Society (NASBS). Design  An online-based survey was designed and distributed to the membership of the NASBS. Data was analyzed using bivariate analysis and logistic regression modeling. Setting  Online-based questionnaire. Participants  NASBS membership. Main Outcome Measures  Use of intraoperative antibiotics and use of postoperative antibiotics. Results  The survey response rate was 26% (208 respondents). Of the 208 total respondents, 143 (69%) respondents performed LSBS. Most respondents are neurosurgeons (69%) with the remaining being otolaryngologists (31%). The majority of respondents (79%) are fellowship-trained in skull base surgery. Academic or government physicians make up 69% of respondents and 31% are in private practice with or without academic affiliations. Bivariate analysis showed that practice setting significantly influenced intraoperative antibiotic use (p  = 0.01). Geographic location significantly affected postoperative antibiotic use (p  = 0.01). Postoperative antibiotic duration was significantly affected by presence of chronic otitis media, cerebrospinal fluid leak, and surgeon training (p  = 0.02, p  = 0.01, and p  = 0.006, respectively). Logistic regression modeling showed that the motivation to reduce infection significantly impacted postoperative antibiotic use (p  = 0.03). Conclusion  This study demonstrates significant variations in intraoperative and postoperative antibiotic use in LSBS among the NASBS membership. Appropriate guidelines for optimal perioperative antibiotic use patterns should be determined with randomized studies in the future. [ABSTRACT FROM AUTHOR]

Published
2022
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72. Postoperative Infection Rate and Associated Factors Following Endoscopic Sinus Surgery.

Author

Shah, Sharan J., Hawn, Vivian S., Zhu, Nina, Fang, Christina H., Gao, Qi, Akbar, Nadeem A., and Abuzeid, Waleed M.

Subjects
ADRENOCORTICAL hormones, ACQUISITION of data methodology, ACADEMIC medical centers, CONFIDENCE intervals, MULTIVARIATE analysis, RETROSPECTIVE studies, DISEASE incidence, RISK assessment, SINUSITIS, SURGICAL site infections, POSTOPERATIVE period, MEDICAL records, LOGISTIC regression analysis, ODDS ratio, ENDOSCOPY, LONGITUDINAL method, ANTIBIOTICS, DISEASE risk factors
Abstract

Objectives: There is a paucity of data on postoperative infections after endoscopic sinus surgery and associated risk factors. Our objective was to evaluate a cohort of patients undergoing endoscopic sinus surgery (ESS) for chronic rhinosinusitis to determine which perioperative factors may be associated with infection in the 30-day postoperative period. Methods: A retrospective cohort study of adults who underwent ESS at a tertiary academic medical center from 2015 to 2018 was performed. The primary outcome was incidence of postoperative infection, defined by identification of sinus purulence on nasal endoscopy necessitating antibiotics within 30 days of surgery. Independent variables collated included the result of postoperative cultures and use of perioperative antibiotics, oral corticosteroids, packing, and steroid-eluting stents. Statistical analysis involved bivariate analysis to identify variables that correlated with postoperative infection and subsequent multivariate logistic regression to identify independent risk factors. Results: Three hundred seventy-eight unique ESS cases performed in 356 patients were reviewed. The mean age was 46 years (range, 18-87). The most common indication for surgery was chronic rhinosinusitis without nasal polyposis. The postoperative infection rate was 10.1%. The most commonly cultured pathogen was Staphylococcus aureus. Multivariate logistic regression analysis showed that postoperative systemic corticosteroid use was the only risk factor independently associated with infection (OR 3.47 [95% CI 1.23-9.76], P =.018). Conclusion: The incidence of postoperative infection following ESS was 10.1%. The use of postoperative systemic corticosteroids independently increased the risk of infection by 3.47-fold. [ABSTRACT FROM AUTHOR]

Published
2022
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74. Endoscopic Sinus Surgery Improves Aspirin Treatment Response in AERD Patients

Author

Shah, Sharan J., Abuzeid, Waleed M., Ponduri, Anusha, Pelletier, Teresa, Ren, Zhen, Keskin, Taha, Roizen, Gigia Gottlieb, Rosenstreich, David, Ferastraoaru, Denisa, and Jerschow, Elina

Subjects
Adult, Male, Aspirin, Anti-Inflammatory Agents, Non-Steroidal, Nasal Surgical Procedures, Endoscopy, Immunoglobulin E, Middle Aged, Article, Treatment Outcome, Desensitization, Immunologic, Humans, Asthma, Aspirin-Induced, Female
Abstract

Aspirin desensitization and treatment benefits most patients with aspirin-exacerbated respiratory disease (AERD), although some patients fail therapy. Our objective was to assess whether recent endoscopic sinus surgery (ESS) improved aspirin treatment outcomes in AERD patients who initially failed aspirin therapy.Outcomes of aspirin desensitization and treatment in AERD patients prospectively enrolled were assessed preoperatively and at 4, 12, and 24 weeks after ESS by determining changes in Asthma Control Test (ACT) and Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) scores and respiratory function. Biomarkers, including fractional excretion of nitric oxide (FeNO), spirometry, nasal inspiratory peak flow (NPF), immunoglobulin E (IgE), and eosinophil count, were measured.Nineteen patients who benefited (responders) and 21 patients who failed (nonresponders) preoperative aspirin treatment with a distant history of ESS (mean, 48 months) were identified. Nonresponders were more likely to be African American (71%, p0.01) and have higher baseline IgE levels (252 kU/L vs 87 kU/L in responders, p0.01). 24 of the 40 patients (nine responders and 15 non-responders) required subsequent ESS and underwent another aspirin desensitization 3-4 weeks after ESS. All 24 patients tolerated a second round of aspirin desensitization and treatment. The primary aspirin therapy was associated with a significant increase in IgE in nonresponders, but there was no significant increase in IgE after the second aspirin desensitization and treatment.Antecedent ESS enhances aspirin treatment responses in AERD patients and may convert patients who failed aspirin treatment before surgery to a more responsive phenotype after ESS. Patients with higher baseline serum IgE levels may benefit from ESS performed shortly before aspirin desensitization and therapy.

Published
2019

77. Is There a Role for Bedside Biopsy in the Evaluation of Acute Invasive Fungal Rhinosinusitis?

Author

Abuzeid, Waleed M., Trott, Elliott, Jafari, Aria, Moe, Kris S., and Humphreys, Ian M.

Abstract

Delays in biopsy may setback treatment and contribute to increased morbidity and mortality.2 Though computed tomography (CT) and magnetic resonance imaging can be acquired rapidly, the changes on imaging suggestive of AIFRS may not present until later in the disease course. Recommend biopsy if abnormal endoscopy or ANC 500/ L or positive CT4No differentiation between bedside vs operating room-based biopsy results. Acute invasive fungal rhinosinusitis (AIFRS) is a rapidly progressive and life-threatening condition that predominantly affects immunocompromised patients. [Extracted from the article]

Published
2022
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83. Neutrophilic inflammation and epithelial barrier disruption in nasal polyps characterize non‐steroidal anti‐inflammatory drug exacerbated respiratory disease.

Author

Andiappan, Anand Kumar, Asad, Mohammad, Chua, Celine, Sehanobish, Esha, Ren, Zhen, Chan, Xue Ying, Lum, Josephine, Ang, Nicholas, Duan, Kaibo, Gersten, Adam, Abuzeid, Waleed M., Akbar, Nadeem, Gibber, Marc, Howland, Shanshan, Lee, Bernett, Rotzschke, Olaf, Porcelli, Steven A., and Jerschow, Elina

Subjects
NASAL polyps, RESPIRATORY diseases, ANTI-inflammatory agents, RESPIRATORY agents, INFLAMMATION, IMMUNOGLOBULIN E
Abstract

Conversely, tissue neutrophil association with LM scores in N-ERD patients suggests that neutrophils contribute to the severity of the polyp burden in N-ERD. Neutrophilic inflammation and epithelial barrier disruption in nasal polyps characterize non-steroidal anti-inflammatory drug exacerbated respiratory disease Neutrophil counts were higher in the nasal polyp tissues of N-ERD patients (8.5 cells per hpf (IQR 3-25) vs. 2.5 cells (IQR 2-5) in non-N-ERD ( I p i = .026, Figure 1B). [Extracted from the article]

Published
2022
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84. The surgical handoff: implications and future directions for otolaryngology

Author

Abuzeid, Waleed M., Akbar, Nadeem A., and Zacharek, Mark A.

Subjects
Medical personnel -- Malpractice, Communication in medicine -- Standards, Patient transfer -- Safety and security measures -- Research, Health
Abstract

Effective communication is essential to patient safety and quality of care. In fact, communication problems have been cited as contributing factors in 26 to 31% of medical malpractice claims. (1) [...]

Published
2012

85. Contributors

Author

Abdul-Aziz, Dunia, Abuzeid, Waleed M., Adams, Meredith E., Adamson, Peter A., Agamah, Edem S., Agrawal, Yuri, Ahmad, Faisal I., Ahmed, Mostafa M., Akst, Seth A., Albergotti, W. Greer, Albers, Sheri L., Allen, Clint T., Alsaied, Abdulmalik S., Alwani, Mohamedkazim, Alyono, Jennifer Christy, Anderson, Carryn, Armstrong, William B., Arnold, Michelle G., Arriaga, Moises A., Arts, H. Alexander, Arvedson, Joan C., Ashram, Yasmine A., Aygun, Nafi, Backous, Douglas D., Baker, Shan R., Balkany, Thomas J., Balsalobre, Leonardo, Baroody, Fuad M., Bastian, Robert W., Basura, Gregory J., Batra, Pete S., Beadle, Beth M., Beckmann, Nicholas A., Bekeny, James R., Bell, Diana M., Bell, Elizabeth Bradford, Benninger, Michael S., Bernknopf, Heidi J., Beswick, Daniel M., Bhattarai, Mukul, Bleier, Benjamin S., Blevins, Nikolas H., Blitzer, Andrew, Boahene, Kofi, Bohm, Lauren A., Bottros, Michael M., Brackmann, Derald E., Bradford, Carol R., Branham, Gregory H., Branstetter, Barton F., IV, Brant, Jason A., Brietzke, Scott E., Brinkmeier, Jennifer, Brodie, Hilary A., Brown, Bena, Budenz, Cameron L., Burns, Clare, Byrd, J. Kenneth, Byrne, Patrick, Cai, Yi, Calloway, Hollin, Campisi, Paolo, Carey, John P., Carniol, Eric T., Carr, Simon D., Casazza, Geoffrey C., Casper, Keith, Castelnuovo, Paolo, Cejas, Ivette, Chang, Kay W., Chegar, Burke E., Cheng, Alan G., Cheng, Alan T.L., Chepeha, Douglas B., Chien, Wade W., Chin, Oliver Y., Choi, Sukgi S., Chole, Richard A., Choudhury, Baishakhi, Christian, James M., Chun, Robert H., Citardi, Martin J., Compton, Andrew Michael, Cosetti, Maura K., Council, M. Laurin, Courey, Mark S., Cover, Renee, Cox, Daniel R., Crane, Benjamin T., Creighton, Francis X., Jr, Crowson, Matthew G., Culicchia, Frank, Cummings, Charles W., Cunningham, Calhoun D., III, Cushing, Sharon L., Dahlin, Brian C., Daniel, Sam J., Dassi, Camila Soares, Day, Terry A., Dedhia, Kavita, Dedmon, Matthew M., Deep, Nicholas L., Della Santina, Charles C., Demke, Joshua C., Derkay, Craig S., Dewyer, Nicholas A., Diaz, Rodney C., Dilger, Amanda E., Driver, Lynn E., Durham, Alison B., Eisbruch, Avraham, Eisele, David W., Eisenberg, Laurie, El-Deiry, Mark, El Rassi, Edward, El-Kashlan, Hussam K., Elliott, Anila B., Elluru, Ravindhra G., Emmett, Susan D., Eu, Donovan, Fakhri, Samer, Fakhry, Carole, Farrior, Edward H., Feller-Kopman, David, Felts, Charles B., Fink, Daniel S., Fletcher, Kenneth C., Jr, Flint, Paul W., Floyd, Elizabeth M., Fokkens, Wytske J., Francis, Howard W., Friedland, David R., Friedman, Oren, Friedman, Rick A., Frodel, John L., Jr, Ganly, Ian, Gantous, Andres, Gantz, Bruce J., Garrett, C. Gaelyn, Gillespie, M. Boyd, Girod, Douglas A., Glick, Hannah, Goddard, John C., Goding, George S., Jr, Goldberg, Andrew N., Goldenberg, David, Goldstein, Nira A., Gonik, Nathan J., Gonzalez, Debra, Gourin, Christine G., Graham, M. Elise, Green, Glenn E., Green, Stephen T., Grégoire, Vincent, Grimmer, J. Fredrik, Gruffi, Catherine A., Gubbels, Samuel P., Gupta, Piyush, Gurgel, Richard K., Gurrola, Jose G., II, Ha, Jennifer F., Ha, Patrick K., Hajnas, Natalia M., Hamilton, Bronwyn E., Hamilton, Grant S., III, Hamoir, Marc, Hanna, Ehab Y., Harmon, Jeffrey J., Jr, Harréus, Ulrich, Banakis Hartl, Renee, Harvey, Richard, Haughey, Bruce H., Hawkins, Peter, Hellings, Peter, Hellstein, John W., Herzer, Kurt, Hilgers, Frans J.M., Hill, Justin D., Hillel, Alexander T., Hinni, Michael L., Hirce, Kellie J., Hoffman, Henry T., Holman, Ashlee E., Hom, David B., Hopkins, Claire, Houlton, Jeffrey J., House, John W., Hullar, Timothy E., Hummel, Thomas, Humtsoe, Joseph O., Hwang, Peter H., Ishman, Stacey L., Jabbour, Jad, Jackler, Robert K., Jackson, Neal M., James, Adrian L., Jameson, Brian, Jan, Taha A., Jenkins, Herman A., Jiam, Nicole T., Jin, Hong-Ryul, Johnson, Christopher M., Johnson, Timothy M., Kamani, Dipti, Karle, William E., Kavitt, Robert T., Kaylie, David M., Kellman, Robert M., Kennedy, David W., Kern, Robert C., Kerolus, Julia L., Kesser, Bradley W., Khan, Majid, Kileny, Paul R., Kim, Jennifer, Kimple, Adam J., King, Ericka F., Kirke, Diana N., Knecht, Elizabeth, Konior, Raymond J., Kraft, Shannon M., Kridel, Russell W.H., Kuan, Edward C., Kumar, Parvesh, Kunduk, Melda, Laccourreye, Ollivier, Lai, Stephen Y., Lal, Devyani, Lalwani, Anil K., Lam, Derek J., Lambert, Paul R., Larsen, Christopher G., Latchaw, Richard E., Lawlor, Claire M., Le Prell, Colleen G., Leahy, Kevin P., Lee, Daniel J., Lee, Edward R., Lee, Nancy, Lesperance, Marci M., Lester, Laeben, Levi, Jessica, Lewis, James S., Jr, Li, Daqing, Lian, Timothy S., Liddy, Whitney, Limb, Charles J., Lin, Frank R., Linkov, Gary, Loh, Thomas, Lorenz, Kai Johannes, Lott, David G., Lund, Valerie J., Lustig, Lawrence R., Lysakowski, Anna, Maisel, Robert H., Makki, Fawaz, Mangat, Devinder S., Marchioni, Daniele, Mark, Lynette J., Markt, Jeffery C., Marsh, Michael, Mattavelli, Davide, Mattox, Douglas E., McCrary, Hilary C., McGee, JoAnn, McGinn, Johnathan D., Mehta, Kinneri, Meier, Jeremy D., Merati, Albert L., Messing, Barbara P., Messner, Anna H., Meyer, Anna, Mierzwa, Michelle, Milczuk, Henry A., Millar, Jennifer L., Miller-Thomas, Michelle, Minor, Lloyd B., Misono, Stephanie, Mitchell, Jenna L., Mobley, Steven Ross, Moore, Eric J., Mostovych, Nadia K., Mowry, Sarah, Muntz, Harlan R., Mydlarz, Wojciech K., Nadimi, Sahar, Nadol, Joseph B., Jr, Naples, James G., Nassif, Paul S., Naunheim, Matthew R., Neel, Gregory S., Nelson, Marc E., Nelson, Rick F., Nicolai, Piero, Nieman, Carrie L., Noel, Richard J., Nouraei, S.A. Reza, Nugent, Ajani, Nuss, Daniel W., Nussenbaum, Brian, Odland, Rick M., Ohye, Richard G., O'Malley, Bert W., Jr, O'Reilly, Robert C., Orlandi, Richard R., Orlowski, Hilary L.P., Ottaviano, Giancarlo, Pagedar, Nitin A., Palmer, James N., Papsin, Blake C., Park, Albert H., Park, Stephen S., Parsons, Matthew S., Patterson, G. Alexander, Pellitteri, Phillip K., Perkins, Jonathan A., Perkins, Stephen W., Pierce, Bailey, Pignatari, Shirley S.N., Pletcher, Steven D., Poe, Dennis S., Popovtzer, Aron, Postma, Gregory N., Prueter, James C., Puglia, Michael P., II, Qian, Z. Jason, Quesnel, Alicia M., Rahbar, Reza, Ramachandran, Virginia, Ramakrishnan, Vijay R., Randolph, Gregory W., Rao, Krishna, Rao, Lesley, Rassekh, Christopher H., Reid, Lisa M., Reinisch, Lou, Rettig, Eleni, Rigby, Matthew H., Rivas, Alejandro, Robbins, K. Thomas, Roberts, Daniel S., Roby, Brianne, Roland, J. Thomas, Jr, Ronen, Ohad, Rosbe, Kristina W., Rosenfeld, Richard M., Rotter, Bruce E., Roxbury, Christopher R., Ruckenstein, Michael J., Runge, Christina L., Rybak, Leonard P., Saadi, Robert, Salinas, Thomas J., Samant, Sandeep, Samlan, Robin A., Sandhu, Guri S., Sarber, Kathleen M., Sauder, Cara L., Scher, Richard L., Schilder, Anne G.M., Schindler, Joshua S., Schmalbach, Cecelia E., Schoem, Scott R., Schubert, Michael C., Schulte, Joseph, Schwarz, Yehuda, Sciubba, James J., Sclafani, Anthony P., Seikaly, Hadi R., Selesnick, Samuel H., Senior, Brent A., Sharma, Anu, Sharon, Jeffrey D., Shearer, A. Eliot, Shelton, Clough, Shibata, Seiji B., Shnayder, Yelizaveta, Shuman, Elizabeth A., Sidell, Douglas R., Sinha, Parul, Sirjani, Davud B., Skirko, Jonathan R., Slager, Heidi K., Slattery, William H., III, Smith, Kristine A., Smith, Richard J.H., Smith, Ryan M., Smith, Timothy L., Soler, Zachary M., Spector, Matthew E., Sperry, Steven M., Stach, Brad A., Stachecki, Robert P., Stamm, Aldo Cassol, Stankiewicz, James A., Steitz, Jeffrey T., Stevens, Shawn M., Steward, David L., Stoddard, David G., Jr, Stokken, Janalee K., Sturm, Angela, Subramanian, Melanie, Sunwoo, John B., Swarm, Robert A., Sykes, Jonathan M., Syme, Noah P., Tardy, M. Eugene, Jr., Tatum, Sherard A., III, Taylor, S. Mark, Teasley, Rod A., Telian, Steven A., Terris, David J., Thatcher, Aaron L., Thomas, J. Regan, Timmons, Sherry R., Tjoa, Tjoson, Toriumi, Dean M., Trimarchi, Matteo, Tsue, Terance T., Tu, Nathan C., Turner, Michael D., Uppaluri, Ravindra, Vaezi, Michael F., Van Abel, Kathryn M., van den Brekel, Michiel W.M., Van Gerven, Laura, Venekamp, Roderick P., Verma, Sunil P., Villwock, Jennifer A., Vivas, Esther X., Vokes, David, Wackym, P. Ashley, Walsh, Edward J., Walvekar, Rohan R., Wang, Jennifer R., Wang, Tom D., Ward, Bryan K., Weber, Randal S., Wein, Richard O., Weinstein, Gregory S., Weitzel, Erik K., Welling, D. Bradley, Whitcroft, Katherine Lisa, Wiggins, Richard H., III, Wilkerson, Brent J., Wilkinson, Eric P., Wingo, Melissa L., Wise, Sarah K., Wishart, Laurelie R., Woodson, Erika, Woodson, Gayle Ellen, Wormald, Peter J., Worrall, Douglas M., Wrobel, Bozena B., Xu, Mary Jue, Yackel, Thomas R., Yan, Carol H., Yingling, Charles D., Yu, Diana H., Yu, Yao, Yueh, Bevan, Zafereo, Mark E., Zaldivar, Renzo, Zanation, Adam M., Zdanski, Carlton J., Zee, David S., Zeitler, Daniel M., Zimbler, Marc S., Zinreich, S. James, Zopf, David, and Zwolan, Teresa A.

Published
2021
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91. Differential response to aspirin-lysine of 15-Hydroxyeicosatetraenoic Acid in Nasal Polyp Supernatants from Aspirin-Exacerbated Respiratory Disease Patients

Author

Jerschow, Elina, primary, Edin, Matthew, additional, Han, Weiguo, additional, Lih, Fred B., additional, Gruzdev, Artiom, additional, Bradbury, Alyce J., additional, Abuzeid, Waleed M., additional, Akbar, Nadeem, additional, Pelletier, Teresa, additional, Keskin, Taha, additional, Spivack, Simon, additional, Schuster, Victor, additional, Rosenstreich, David L., additional, and Zeldin, Darryl C., additional

Published
2018
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93. Outcomes of chronic frontal sinusitis treated with ethmoidectomy: a prospective study

Author

Abuzeid, Waleed M., Mace, Jess C., Costa, Milena L., Rudmik, Luke, Soler, Zachary M., Kim, Grace S., Smith, Timothy L., and Hwang, Peter H.

Subjects
Adult, Male, Endoscopy, Middle Aged, Severity of Illness Index, Article, Anti-Bacterial Agents, Frontal Sinusitis, Treatment Outcome, Ethmoid Sinus, Chronic Disease, Quality of Life, Frontal Sinus, Humans, Female, Steroids, Aged
Abstract

In medically refractory chronic frontal sinusitis, ethmoidectomy without instrumentation of the frontal ostium may resolve frontal disease. Our aim was to determine the efficacy of ethmoidectomy alone for the treatment of chronic frontal sinusitis.Adults with chronic rhinosinusitis prospectively enrolled in a multicenter study who demonstrated frontal sinusitis on computed tomography were divided into 2 groups: (1) endoscopic sinus surgery (ESS) incorporating ethmoidectomy, but excluding frontal sinusotomy; and (2) ESS incorporating frontal sinusotomy. The primary outcome was improvement in 22-item Sino-Nasal Outcome Test (SNOT-22) scores. Secondary outcomes included endoscopic scores and use of corticosteroids and antibiotics.A total of 196 cases undergoing frontal sinusotomy and 30 cases treated with ethmoidectomy without frontal sinusotomy were analyzed and were comparable demographically. The prevalence of nasal polyps, previous ESS, asthma, and aspirin intolerance was more common in the frontal sinusotomy group (p0.050). Preoperative endoscopy and computed tomography scores were higher in the frontal sinusotomy group (p ≤ 0.001). Postoperatively, both groups showed comparable SNOT-22 scores with worse endoscopy scores in the frontal sinusotomy group (p = 0.038). Postoperative improvement in SNOT-22 total and subdomain scores was comparable between groups. Nasal endoscopy scores improved to a greater degree in the frontal sinusotomy group (p = 0.023). Duration of postoperative topical steroid use was higher in the frontal sinusotomy group (p = 0.007). Revision surgery was needed in 2.6% of frontal sinusotomy patients and 0% of patients without frontal sinusotomy.The treatment of chronic frontal sinusitis through ethmoidectomy is a potential alternative to frontal sinusotomy achieving similar quality of life (QOL) improvements in patients manifesting less severe sinus disease.

Published
2016

100. Guns n' Noses: Endoscopic Removal of an Air-Gun Pellet Retained in the Frontal Sinus.

Author

Levy, Dylan A., Lee, Andrew Y., Abuzeid, Waleed M., and Akbar, Nadeem A.

Subjects
FRONTAL sinus surgery, ENDOSCOPY, FIREARMS, FOREIGN bodies, PHYSICAL diagnosis, TOMOGRAPHY
Abstract

The article describes the case of a male teenage patient with a penetrating foreign body (FB) retained in the right frontal sinus and was presented to a community emergency department after sustaining an injury to the right eyebrow from an air gun. Topics discussed include result of the computed tomography (CT) scan done on the patient, and percentage of penetrating head and neck traumas that result in retained FBs in the sinuses or skull base.

Published
2020
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