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Copyright of Acta Agriculturae Zhejiangensis is the property of Acta Agriculturae Zhejiangensis Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Medical Equipment Journal is the property of Chinese Medical Equipment Journal Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the genetic polymorphism of 18 autosomal short tandem repeats (STR) loci in 2 323 healthy unrelated individuals of Minjia branch of Bai nationality in Yunnan, calculate the population genetic parameters, and establish the genetic data of Minjia branch of Bai nationality in Yunnan, so as to provide the scientific basis for the parental identification and individual identification of forensic material evidence. Methods A total of 2 323 unrelated individuals from Minjia branch of Bai nationality population were collected. DNA TyperTM 19 kit was used for direct PCR compound amplification. AB 3130XL automatic genetic analyzer was used to separate the PCR compound amplification products by capillary electrophoresis. STR typing was performed with GeneMapper ID-x 1.5 software. Forensic parameters, such as allele frequency and matching probability, were calculated by Modified Powerstats software, and the hardy-Weinberg equilibrium (HWE) test was performed. The Fst and P values were calculated using Arlequin software. Nei’ s genetic distance was calculated using Phylip software. Multi-dimensional scale (MDS) analysis was performed using SPSS software. The Neighbor-Joining (NJ) phylogenetic tree was constructed by Mega software. Results A total of 230 alleles and 1 073 genotypes were observed at 18 STR loci. Except that D13S317 loci was not in accord with Hardy-Weinberg equilibrium ( P = 0.000 8）, the allele frequencies and genotype frequencies of other loci were consistent with Hardy-Weinberg equilibrium (P > 0.05/20 = 0.002 5）. The cumulative discrimination power (CDP) and cumulative probability of exclusion (CPE) of 18 STR loci were 0.999 999 999 and 0.999 999 940 55, respectively. The results of Fst, Nei’s genetic distance and NJ phylogenetic tree indicated that the Minjia branch of Bai nationality was close to the Bai nationality in Nujiang and the Bai nationality in Dali, but far away from the Bulang nationality in Yunnan and Va nationality in Yunnan. Conclusion The 18 STR loci mentioned above show the high genetic polymorphism in the Minjia branch of Bai nationality and they can be used for the forensic identification and population genetics research [ABSTRACT FROM AUTHOR]

Objective To describe the characteristics and registration status of clinical trials of new drugs for nonalcoholic steatohepatitis (NASH), and to provide a reference for the design and implementation of clinical trials of new drugs for NASH. Methods The U. S. Clinical Trials Database, China Clinical Trial Registry, and Center for Drug Evaluation, National Medical Products Administration, were searched for clinical trials of new drug registration and interventional studies with NASH as the indication published up to August 6, 2021, using NASH in English and Chinese characters as the keywords, and liver cirrhosis was excluded. Two researchers independently searched and screened the articles to extract relevant information. Results A total of 196 clinical trials of new drug registration or interventional studies for NASH were included, among which there were 174 trials registered abroad and 22 trials registered in China, and the number of registrations tended to increase year by year. The numbers of phase I, phase I/II (including lb/ Ila), phase II, phase II/ III, and phase III clinical trials were 45 (23.0%), 8 (4.1 %), 112(57.1 %), 4 (2.0%), and 19 (9.7%), respectively. The main drug types included farnesoid X receptors, fibroblast growth factors, peroxisome proliferator - activated receptor agonists, and glucagon - like peptide - 1, with numbers of 16 (8.16%), 14 (7.14%), 11 (5.61 %), and 13 (6.63 %), respectively. The clinical trials of innovative drugs for NASH initiated by the sponsors in European and American regions accounted for the highest proportion, and there was a gradual increase in the number of clinical trials of innovative drugs in China in recent years, with a similar distribution of single - center and multicenter clinical trials. As for the trials with NASH patients as subjects, the numbers of trials with pathology, imaging, and clinical diagnosis as the main inclusion criteria were 125, 66, and 42, respectively. Phase I clinical trials used safety, tolerability, and pharmacokinetic parameters as the main assessment indices, while phase II and phase III clinical trials often used safety and efficacy as the main assessment indices. The number of clinical trials for the registration of innovative drugs for NASH was relatively low but kept increasing in China, and there were fewer clinical trials of innovative traditional Chinese medicine drugs compared with innovative chemical drugs. Conclusion There is a significant increase in the registration of international clinical trials of innovative drugs for NASH, and most of these trials are in the early phases, with large differences in inclusion criteria and assessment indices, a lack of unified evaluation indices, and relatively few trials with new designs. There are fewer clinical trials of innovative drugs for NASH in China than in European and American countries, and the number of such trials is gradually increasing in China. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Zhengzhou University: Engineering Science is the property of Editorial Office of Journal of Zhengzhou University: Engineering Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Computer Measurement & Control is the property of Magazine Agency of Computer Measurement & Control and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Modern Laboratory Medicine is the property of Journal of Modern Laboratory Medicine Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Hydrographic Surveying & Charting / Haiyang Cehui is the property of Hydrographic Surveying & Charting Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: The pathogenesis of osteonecrosis of the femoral head (ONFH) still needs to be further studied, so it is necessary to establish an animal model that can highly simulate ONFH in humans. However, how to correctly evaluate the animal model of ONFH is a prerequisite for establishing the animal model of ONFH. OBJECTIVE: To summarize the evaluation methods of ONFH animal models worldwide in recent years, review the advantages and disadvantages of each evaluation method, explore new evaluation methods, and provide reference for the establishment of animal models. METHODS: Literatures related to the evaluation methods of ONFH animal models published from January 2010 to September 2020 were retrieved in CNKI, WanFang, VIP, PubMed, Web of Science and Medline with the terms “osteonecrosis of femoral head, femoral head necrosis, animal model, evaluation methods” as the retrieval words. RESULTS AND CONCLUSION: A total of 51 articles were included according to the inclusion criteria, including 33 in Chinese and 18 in English. In recent years, with the development of imaging technology and the introduction of new technologies, the evaluation options of ONFH animal model increase. Choosing a reasonable evaluation method can reduce the workload in the process of establishing animal models and provide reference for the follow-up research. So, the further improvement is necessary. [ABSTRACT FROM AUTHOR]

Multi-label data widely exists in the real world, and multi-label feature selection is an important preliminary step in multi-label learning. Based on the fuzzy rough set model, researchers have proposed multi-label feature selection algorithms, but most of these algorithms do not pay attention to the co-occurrence characteristics between labels. In order to solve this problem, the similar relationship between the samples under the label set is evaluated based on the co-occurrence relationship bet ween the sample labels. This relationship is used to define the fuzzy mutual information between the feature and the label. Combining the principle of maximum correlation and minimum redundancy, a multi-label feature selection algorithm is designed. Experiments on 5 public data sets show the effectiveness of the proposed algorithm. [ABSTRACT FROM AUTHOR]

Copyright of Secretary (16742354) is the property of Secretary Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Medical Equipment Journal is the property of Chinese Medical Equipment Journal Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: The development of a model of femoral head necrosis has been slow, and most studies have not elaborated the advantages and disadvantages of various animal models and optimal selection methods OBJECTIVE: To explore the most suitable animal modeling methods and modeling ideas, summarize the advantages and disadvantages of each model, and point out the existing problems and solutions, providing basis and ideas for the subsequent research on femoral head necrosis. METHODS: A search of CNKI, PubMed, and WanFang databases was performed for relevant articles published from 2009 to 2020 using the keywords of “osteonecrosis of the femoral head, animal model, osteoarthritis, collapse of the femoral head, trauma, corticosteroid, alcohol, liquid nitrogen” in Chinese and English, respectively. Finally, 55 eligible articles were included for review. RESULTS AND CONCLUSION: Common causes of femoral head necrosis include alcohol, hormones, and mechanical trauma. Among them, there is no vomiting reflex center in rats, which is more commonly used in alcohol-based modeling. The mechanism of hormone-induced osteonecrosis of the femoral head is still unclear, mainly including three hypotheses: fat metabolism disorder, intravascular coagulation and osteoporosis. The pathogenesis of hormone-induced modeling in animal experiments is similar to humans, and it can also reflect the pathological changes of femoral head necrosis in the advanced stage. After the trauma, the femoral head suffers subchondral fracture and local collapse caused blood circulation disorder, which causes ischemic necrosis of the femoral head. But in animal experiments, the pathogenesis of trauma in animals is different from that of humans. However, there are certain problems in various animal studies: (1) In the modeling of hormone-induced models, there is no unified standard for the selection and dosage of hormones, and the uncertainty of the site of model necrosis. (2) The freezing dog model is more popular in recent years, but it lacks mature and accurate operation methods. The uncertainty of the freezing range has a certain impact on the later stage of modeling. (3) The pathogenesis in most trauma models is different from human pathogenesis. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Environmental Science & Technology (10036504) is the property of Editorial Board of Environmental Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Sedimentologica Sinica is the property of Acta Sedimentologica Sinica Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Practical Pharmacy & Clinical Remedies is the property of Editorial Department of Practical Pharmacy & Clinical Remedies and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Ecology & Rural Environment is the property of Journal of Ecology & Rural Environment Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Inorganic Analytical Chemistry / Zhongguo Wuji Fenxi Huaxue is the property of Beijing Research Institute of Mining & Metallurgy Technology Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Brewing is the property of China Brewing Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Brewing is the property of China Brewing Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Satellite based augmentation system (SBAS) improves the accuracy and integrity of user positioning by broadcasting ephemeris corrections and associated integrity parameters through geostationary earth orbit satellites in real time. Minimum variance estimation method is proposed to derive the GPS ephemeris corrections and a Chi-square test is performed on the residual errors of corrected ephemeris to meet the integrity requirement. Satellite user differential range error (UDRE) and scaling matrix contained in message type 28 (MT28) are calculated based on the covariance information with the assumption that one of the reference stations failed. Actual data collected by 27 stations spread over China are applied to verify the proposed algorithm. International GNSS Service precise clock and orbit products are firstly taken as reference to assess the accuracy of ephemeris corrections. Results indicate that an accuracy of 0.1 m for clock and 0.4 m for orbit corrections can be obtained. Then， corrections of GPS broadcast ephemeris are estimated， the integrity parameters including UDRE and MT28 are generated. Chi⁃square test results of the ephemeris remaining errors show no exceeding of the threshold which reveals the integrity of corrections. A clear dependence of UDRE on satellite elevation is presented. On board clock failure and satellite maneuvering were simulated to evaluate the performance of the proposed algorithm. Measurement errors introduced by satellite abnormity can be effectively detected and compensated by the algorithm. With ionospheric delay corrected by Klobuchar model and ephemeris corrections generated in this contribution, SBAS positioning results achieve the accuracies of 0.7 m in horizontal direction and 1.0 m in vertical direction， which show an improvement of 30% in horizontal direction and 40% in vertical direction compared with the GPS single point positioning results. [ABSTRACT FROM AUTHOR]

Copyright of Secretary (16742354) is the property of Secretary Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Modern Medicine & Health is the property of Journal of Modern Medicine & Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To explore the relationship among serum 25-hydroxyvitamin D [25-(OH)D], vitamin D receptor (VDR) gene polymorphism, and bone erosion in patients with rheumatoid arthritis. Methods Ninety-four patients with rheumatoid arthritis were divided into study group and 85 healthy persons were divided into health group. The serum 25- (OH)D levels were detected in the 2 groups. The genomic DNA was extracted and the VDR gene was detected using MassARRAY molecular weight array technology platform. The relationship between serum 25-(OH)D level and VDR gene polymorphism and bone erosion in rheumatoid arthritis was analyzed. Results The serum 25-(OH)D level in the study group was significantly lower than that in the healthy group (P<0.05), and it was lower in the patients with bone erosion than in the patients without bone erosion (P<0.05). The frequencies of genotype FF, Ff, and allele F of FokI locus and genotype AA, and allele A of ApaI locus in the study group were significantly higher than those in the healthy group (P<0.05). The frequencies of genotype ff and aa in the study group were significantly lower than those in the healthy group (P<0.05). Serum 25-(OH) D less than 30 ng/mL, FokI genotype FF and Ff, and ApaI genotype AA and Aa were risk factors for rheumatoid arthritis (P < 0.05). Serum 25-(OH)D less than 20 ng/mL was a risk factor for bone erosion in rheumatoid arthritis (P<0.05). Conclusion Lack of serum 25-(OH)D increases the risk of bone erosion in patients with rheumatoid arthritis. The allele F of FokI and the allele of ApaI of VDR gene increase the risk of rheumatoid arthritis, but VDR gene is not associated with bone erosion. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Shenzhen University Science & Engineering is the property of Editorial Department of Journal of Shenzhen University Science & Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Architecture & Civil Engineering is the property of Chang'an Daxue Zazhishe and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal on Communication / Tongxin Xuebao is the property of Journal on Communications Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Electronic Components & Materials is the property of Electronic Components & Materials and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)