849 results on '"Oral allergy syndrome"'
Search Results
802. 566 Oral allergy syndrome: A warning?
- Author
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Michelle Melanson and Fanny Silviu-Dan
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medicine.medical_specialty ,Oral allergy syndrome ,business.industry ,Immunology ,Immunology and Allergy ,Medicine ,business ,medicine.disease ,Dermatology - Published
- 2000
803. 433 Association between peanut allergy and birch oral allergy syndrome
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Kathryn Parbhoo, Hazel Frewin, and Douglas S. Robinson
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medicine.medical_specialty ,Oral allergy syndrome ,business.industry ,Immunology ,Peanut allergy ,medicine ,Immunology and Allergy ,business ,medicine.disease ,Dermatology - Published
- 2000
804. Oral allergy syndrome with contact urticaria from cosmetic creams
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E, Rudzki, E, Zawisza, P, Rapiejko, P, Rebandel, and E, Jaworski
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Adult ,medicine.medical_specialty ,Allergy ,Urticaria ,media_common.quotation_subject ,Cosmetics ,Dermatology ,Oral cavity ,Ointments ,Contact urticaria ,Oral allergy syndrome ,Immunopathology ,medicine ,Humans ,Immunology and Allergy ,Skin Tests ,media_common ,Plant Extracts ,business.industry ,Syndrome ,Allergens ,medicine.disease ,Dermatitis, Allergic Contact ,Female ,Mouth Diseases ,business ,Contact dermatitis - Published
- 1999
805. Oral allergy syndrome (OAS) to grapes
- Author
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M F Claude, R. Rassemont, J. Laurent, and M.T. Guinnepain
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medicine.medical_specialty ,Oral allergy syndrome ,business.industry ,Immunology ,MEDLINE ,medicine ,Immunology and Allergy ,medicine.disease ,business ,Dermatology - Published
- 1998
806. Cor a 1–reactive T cells and IgE are predominantly cross-reactive to Bet v 1 in patients with birch pollen–associated food allergy to hazelnut.
- Author
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Hofmann, Claudia, Scheurer, Stephan, Rost, Kathrin, Graulich, Edith, Jamin, Annette, Foetisch, Kay, Saloga, Joachim, Vieths, Stefan, Steinbrink, Kerstin, and Adler, Henric S.
- Subjects
FOOD allergy ,T cells ,IMMUNOGLOBULIN E ,BIRCH ,CELL culture ,HAZELNUTS ,DENDRITIC cells ,OVALBUMINS ,IMMUNOTHERAPY - Abstract
Background: IgE- and T-cell cross-reactivity contribute to the birch pollen–food syndrome. Objectives: We performed a comprehensive analysis of T-cell cross-reactivity in primary cell cultures, facilitating the identification of allergen-specific T-cell subpopulations from individual patients. Methods: Patients with birch pollen allergy and associated food allergy to hazelnuts, carrots, or both were analyzed for IgE cross-reactivity, T-cell responses, and T-cell cross-reactivity to recombinant Bet v 1.0101 (Bet v 1; birch), Cor a 1.0401 (Cor a 1; hazelnut), and Dau c 1.0104 (Dau c 1; carrot). A novel flow cytometry–based method using a 2-step staining process with fluorescent dyes was established to identify subpopulations of cross-reactive T cells. Results: IgE-binding inhibition tests of individual sera revealed that the vast majority of Cor a 1–reactive IgE was cross-reactive to Bet v 1, whereas Bet v 1–reactive IgE was only partially inhibited by preincubation with Cor a 1. Primary stimulation of T cells with Bet v 1 or Cor a 1 resulted in a significant increase in specific responses to Cor a 1 or Bet v 1 after secondary stimulation, respectively, indicating T-cell cross-reactivity between birch and hazelnut allergens in all patients of the study cohort. Preactivation with Dau c 1 induced less pronounced effects. A novel flow cytometry–based proliferation assay identified a predominant Cor a 1/Bet v 1–cross-reactive T-cell subpopulation within highly Bet v 1/Cor a 1–responsive T cells. Conclusion: Analysis of primary allergen-specific T cells combined with flow cytometry–based proliferation assays facilitates investigation of allergen-specific T-cell subpopulations in subjects and might be helpful to evaluate the effect of birch-specific immunotherapy on pollen-associated food allergies. [ABSTRACT FROM AUTHOR]
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- 2013
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807. Oral allergy syndrome in children.
- Author
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Ivković-Jureković I
- Subjects
- Adolescent, Age Factors, Allergens immunology, Asthma immunology, Child, Child, Preschool, Cross Reactions, Dermatitis, Atopic immunology, Female, Food Hypersensitivity immunology, Fruit, Humans, Immunoglobulin E analysis, Male, Pollen, Rhinitis, Allergic, Seasonal immunology, Sex Factors, Skin Tests, Vegetables, Food Hypersensitivity diagnosis, Rhinitis, Allergic, Seasonal diagnosis
- Abstract
Oral allergy syndrome (OAS) is an allergic reaction that occurs after consumption of fresh fruits and vegetables in patients with allergy to pollen. It is mediated by immunoglobulin E (IgE) antibodies and symptoms arise as a result of cross-reactivity between pollen and plant-derived food. OAS is rarely seen in young children, but the prevalence increases with age. The objectives of the study were to identify the prevalence of OAS and probable risk factors in children and adolescents with seasonal allergic rhinitis (AR). One-hundred and twenty patients with seasonal AR were included. Patients were diagnosed based on their clinical history, skin prick test outcome and specific IgE. In patients describing OAS, prick-by-prick tests with fresh fruit or vegetables were carried out. Thirty-two patients had OAS and it was more frequent in female patients than in male patients. OAS was more frequent in adolescents than in small children and in patients with higher total IgE. OAS was significantly more prevalent in patients with AR and asthma (P=0.0016), as was the case in patients with AR and atopic dermatitis (P=0.0004). OAS is rarely diagnosed in small children, partly because of an inadequate clinical history. Patients with OAS may have some risk factors in addition to pollen allergy, and those with more severe atopy are more likely to develop OAS., (© 2015 FDI World Dental Federation.)
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- 2015
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808. The prevalence of the oral allergy syndrome and pollen-food syndrome in an atopic paediatric population in south-west Sydney.
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Brown CE and Katelaris CH
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- Adolescent, Age Distribution, Allergens immunology, Australia epidemiology, Child, Child, Preschool, Cross-Sectional Studies, Female, Food Hypersensitivity diagnosis, Humans, Hypersensitivity, Immediate immunology, Male, Pediatrics, Pollen immunology, Prevalence, Rhinitis, Allergic, Seasonal epidemiology, Rhinitis, Allergic, Seasonal immunology, Risk Assessment, Sex Distribution, Skin Tests methods, Surveys and Questionnaires, Syndrome, Urban Population, Allergens adverse effects, Allergens classification, Food Hypersensitivity epidemiology, Food Hypersensitivity immunology, Hypersensitivity, Immediate epidemiology, Pollen adverse effects
- Abstract
Aim: Oral allergy syndrome (OAS) and pollen-food syndrome (PFS) are regarded as uncommon manifestations of paediatric atopic disease. However, little Australian data exist. The aim of this study was to examine the prevalence of OAS in an atopic, paediatric population., Methods: This cross-sectional study assessed 163 patients aged 4-17 years from the Paediatric Allergy & Immunology Clinic at Campbelltown Hospital, which serves a population base >250,000 with approximately 28% under the age of 18 years. A questionnaire was administered and skin prick tests (SPTs) were performed utilising commercial extracts and fresh and frozen fruit samples. Frozen samples were created by reducing fresh fruit to a semi-solid state and storing at -20 degrees Celsius for up to 6 months., Results: Within the studied population, the prevalence of OAS was 14.7%, PFS 4.9%, PFS in those with allergic rhinitis 6.25% and PFS in those with allergic rhinitis and pollen sensitisation 12.1%. All PFS-implicated fruits were tropical fruits with watermelon the most common. The prevalence of OAS caused by food allergy was 13.6%, implicating peanut most frequently. The most common cause of OAS was immunoglobulin E-mediated food allergy (57.9%). Only frozen samples of watermelon, pineapple and rockmelon produced results consistent with the 'gold standard' of fresh fruit SPT., Conclusion: This study suggests the prevalence of OAS and PFS are more common in paediatric populations than previously described, with tropical fruits predominantly implicated in PFS. Further research is required to determine whether frozen fruits are a reliable alternative to fresh fruit in SPT., (© 2014 The Authors. Journal of Paediatrics and Child Health © 2014 Paediatrics and Child Health Division (Royal Australasian College of Physicians).)
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- 2014
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809. Birch pollen–related food allergy: Clinical aspects and the role of allergen-specific IgE and IgG4 antibodies.
- Author
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Geroldinger-Simic, Marija, Zelniker, Thomas, Aberer, Werner, Ebner, Christof, Egger, Cornelia, Greiderer, Antonia, Prem, Nicole, Lidholm, Jonas, Ballmer-Weber, Barbara K., Vieths, Stefan, and Bohle, Barbara
- Subjects
FOOD allergy ,ALLERGIC rhinitis ,BIRCH ,IMMUNOGLOBULIN E ,DISEASE prevalence ,APPLES ,HAZELNUTS - Abstract
Background Patients with birch pollen allergy often develop allergic reactions to plant foods. Objective To evaluate the prevalence, main symptoms, and triggers of birch pollen–related food allergy and the role of food-specific IgG 4 antibodies in food tolerance. Methods Food-induced symptoms were evaluated in 225 individuals with birch pollen allergy by using a standardized questionnaire. IgE and IgG 4 levels specific for the major birch pollen allergen Bet v 1 and birch profilin Bet v 2 and the Bet v 1 homologs in apple (Mal d 1) and hazelnut (Cor a 1) were quantified by ImmunoCAP. Mock-treated and IgG-depleted sera from patients tolerating hazelnuts in food challenges were compared for their inhibitory activity for binding of Cor a 1–IgE complexes to B cells. Results In total, 73% of the study population experienced food allergy, which was perennial in 86% of the affected individuals. The oral allergy syndrome was the main clinical manifestation. However, more than 58% of the patients also experienced food-induced rhinoconjunctivitis. Apples and hazelnuts were identified as the most frequent triggers. Food allergy correlated with IgE reactivity to Bet v 1 but not to Bet v 2. Mal d 1–specific and Cor a 1–specific IgG 4 /IgE ratios were significantly higher in food-tolerant individuals than individuals with food allergy. Sera from IgG 4 -positive food-tolerant patients possessed IgG-dependent IgE-inhibitory activity. Conclusion Birch pollen–related food allergy is highly prevalent and often perennial. High food allergen–specific IgG 4 /IgE ratios seem associated with food tolerance, potentially because specific IgG 4 blocks IgE binding to food allergens. Thus, the presence of food allergen–specific IgG 4 antibodies is no diagnostic marker for birch pollen–related food allergy. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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810. Atopy: pediatric ENT manifestations in children
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Caruso, Giuseppe, Damiani, Valerio, Salerni, Lorenzo, and Passali, Francesco Maria
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ATOPY , *OTOLARYNGOLOGY , *JUVENILE diseases , *ALLERGY in children , *ALLERGIC rhinitis , *SINUSITIS , *OTITIS , *DENTAL caries - Abstract
Abstract: Objective: The aim of the present study is to discuss the basics of atopy in children in relationship to the principal ENT allergic disorders such as allergic rhinitis, rhinosinusitis and their impact on lower airways, allergic otitis media, and oral cavity focusing on their natural history. Methods: An updated and exhaustive review of principal literature on these topics is performed, underlining the constant but growing interest evoked by these disorders most of all the possible sequelae or complications. Considering the different districts which can be selectively or simultaneously affected by the allergic sensitisation, diagnosis can be a really hard task; in this paper, we tried to draw an integrated diagnostic approach to atopic children and some guidelines for a correct therapeutic approach. Conclusions: Atopic disorders could expose young patients to years of chronic diseases that interferes with their development and with many important aspects of their lives. For these reasons, and considering the high social and medical costs of this disease, it is extremely important to adequately treat allergic pathologies from the early phases of its natural history. Moreover, we cannot forget that an appropriate therapy of allergic pathologies should not be only able to decrease symptoms but, it should also be able to improve patients health related quality of life. [Copyright &y& Elsevier]
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- 2009
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811. ORAL ALLERGY SYNDROME OR ANAPHYLAXIS?
- Author
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Andrea Antico
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Oral allergy syndrome ,business.industry ,Immunology ,Immunology and Allergy ,Medicine ,business ,medicine.disease ,Dermatology ,Anaphylaxis - Published
- 1996
812. ORAL ALLERGY SYNDROME OR ANAPHYLAXIS?
- Author
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Paul Detjen
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Oral allergy syndrome ,business.industry ,Immunology ,medicine ,Immunology and Allergy ,medicine.disease ,business ,Dermatology ,Anaphylaxis - Published
- 1996
813. Food allergy: A clinician’s criteria for including sera in a serum bank
- Author
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Ballmer-Weber, B.K. and Fernández-Rivas, M.
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FOOD allergy , *TRANSGENIC plants , *IMMUNOGLOBULIN E , *FOOD toxicology , *URTICARIA , *SERUM , *ALLERGENS - Abstract
Abstract: Safety assessment for genetically-engineered crop plants includes assessment for allergic responses. To facilitate this assessment, serum banks should contain well-characterised sera from patients with confirmed food allergies. A serum is defined as well-characterised if it is taken from a patient who has a convincing history of allergic responses to a known allergen or an allergen-containing food, a positive skin prick test (or elevated IgE response), and a positive response in a clinical food challenge. [Copyright &y& Elsevier]
- Published
- 2008
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814. 163 A study of RAST titers for fruits, vegetables and pollens in patients with atopic dermatitis and oral allergy syndrome
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Kazuko Kitamura, Hiroyuki Osuna, Junko Osawa, H. Wada, T. Kawaguchi, Sumi Onuma, Zenro Ikezawa, K. Takekawa, and M. Okajima
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medicine.medical_specialty ,business.industry ,Dermatology ,Atopic dermatitis ,medicine.disease ,Biochemistry ,Fruits vegetables ,Titer ,Oral allergy syndrome ,medicine ,In patient ,business ,Molecular Biology - Published
- 1996
815. Oral allergy syndrome?
- Author
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John M. Kelso
- Subjects
medicine.medical_specialty ,Oral allergy syndrome ,business.industry ,Immunology ,Immunology and Allergy ,Medicine ,business ,medicine.disease ,Dermatology - Published
- 1995
816. 014 A study of oral allergy syndrome by apple and chestnut
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K. Tsubaki, Junko Osawa, Sumi Onuma, Kazuko Kitamura, T. Kawaguchi, H. Wada, K. Takekawa, Zenro Ikezawa, and M. Okajima
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medicine.medical_specialty ,Oral allergy syndrome ,business.industry ,medicine ,Dermatology ,medicine.disease ,business ,Molecular Biology ,Biochemistry - Published
- 1995
817. Assessment of cross-reactivity between Japanese cedar (Cryptomeria japonica ) pollen and tomato fruit extracts by RAST inhibition and immunoblot inhibition.
- Author
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Kondo, Y., Tokuda, R., Urisu, A., and Matsuda, T.
- Subjects
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CROSS reactions (Immunology) , *IMMUNOBLOTTING , *AMINO acid sequence - Abstract
Summary Background An association between pollinosis and sensitivity to fruits and vegetables has been reported. Although Japanese cedar (Cryptomeria japonica ) pollinosis is one of the most widespread diseases in Japan, there have been no reports demonstrating cross-reactivity between Japanese cedar pollen and other plant food. Objective The aim of this study was to demonstrate cross-reactivity between Japanese cedar pollen and tomato fruit (Lycopersicon esculentum ) using RAST inhibition and immunoblot inhibition. Methods The RAST and immunoblot inhibition were performed using sera from patients with oral allergy syndrome (OAS) after ingesting fresh tomatoes. We identified some proteins that took part in cross-reactive IgE by the determination of N-terminal amino acid sequences and a homology search through the SWISS-PROT database. Results In the RAST inhibition, the bindings of IgE from the sera from four out of five (4/5) subjects to Japanese cedar pollen discs were inhibited by more than 50% by preincubation of the serum with tomato fruit extracts. Likewise, the IgE bindings to tomato fruit discs were inhibited more than 50% by Japanese cedar pollen extracts in 3/5 sera. In immunoblot inhibition, IgE binding activities of some protein bands on both membranes were decreased by heterologous inhibitors. However, the combinations of these protein bands involved in cross-reactivity were different between patients. Conclusion We have demonstrated cross-reactivity between Japanese cedar pollen and tomato fruit using RAST inhibition and immunoblot inhibition. [ABSTRACT FROM AUTHOR]
- Published
- 2002
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818. Oral allergy syndrome from kiwi fruit after a lover’s kiss.
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Mancuso, G. and Berdondini, R. M.
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- 2001
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819. Allergen cross-reactivity in allergic rhinitis and oral-allergy syndrome: a bioinformatic protein sequence analysis.
- Author
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Platt M, Howell S, Sachdeva R, and Dumont C
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- Allergens adverse effects, Allergens immunology, Animals, Databases, Factual, Food adverse effects, Humans, Mites, Phylogeny, Poaceae, Sequence Analysis, Protein, Trees, Allergens genetics, Computational Biology methods, Cross Reactions genetics, Epitopes genetics, Rhinitis, Allergic immunology
- Abstract
Background: Clinical allergy cross-reactivity that is seen with related inhalant allergens or between unrelated inhalant allergens and foods in oral allergy syndrome (OAS) remains poorly understood. The goal of this study is to determine whether clinical cross-reactivity can be identified from primary protein sequences in allergy epitopes and food proteins., Methods: High-throughput analysis was performed by assembling all known allergy epitopes within the Immune Epitope Database (IEDB; http://www.iedb.org) for 5 common species from 5 inhalant allergen subclasses and comparing their protein sequences to each other, as well as to sequences of intact proteins from known cross-reactive foods in the European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI) protein database (http://www.uniprot.org) that have been implicated in OAS. Computational methods were employed to allow for exact matching, gaps, and similar amino acids using multiple algorithms. A phylogenetic tree was created to determine evolutionary relationships between cross-reactive epitopes in OAS., Results: Twenty-three common inhalant allergens had 4429 unique epitopes; the 19 foods implicated in OAS had 9497 protein sequences. The Basic Local Alignment Search Tool (BLAST) algorithm identified interclass and intraclass sequence similarities for the 5 inhalant allergy classes with high similarity for mites, grasses, and trees. Analysis of OAS proteins identified 104 matches to inhalant allergy epitopes that are known to cross-react. The phylogenetic tree displayed relationships that mostly followed organism phylogeny., Conclusion: Use of primary protein sequences was successful in explaining clinical allergy cross-reactivity. Clinical correlation is needed for use of these epitopes as diagnostic or therapeutic entities for patients with cross-reactive allergic disease., (© 2014 ARS-AAOA, LLC.)
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- 2014
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820. [Oral allergy syndrome in adults of a third level hospital].
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Rodríguez-Mireles KA, Gaspar-López A, López-Rocha EG, Del Rivero-Hernández L, and Segura-Méndez NH
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- Adolescent, Adult, Female, Humans, Male, Middle Aged, Prevalence, Prospective Studies, Skin Tests, Syndrome, Tertiary Care Centers, Young Adult, Food Hypersensitivity epidemiology, Food Hypersensitivity immunology
- Abstract
Background: Oral allergy syndrome (OAS) is the mildest form of an allergic reaction to foods. It is characterized by the presence of IgE mediated symptoms restricted to oral mucosa after intake of fresh fruits and vegetables. OAS diagnosis is based on suggestive clinical manifestations and can be confirmed with tests such as prick-to-prick skin test with the food implicated, which have a sensitivity > 90%, specificity 30-60%, positive predictive value (PPV) of 40% and negative predictive value (NPV) > 95%., Objective: To know the prevalence of OAS in adult patients attending a third level hospital in southern Mexico City, and also describe the demographics of these patients and comorbidities more frequently associated., Patients and Method: We studied 44 patients (40 women and 4 men), with an average age of 33.4 years, with suggestive clinical features of OAS, evaluated with prick-by-prick skin tests with fresh food., Results: There was a predominance of OAS in woman (91%) and a prevalence of asthma and allergic rhinitis of 54% among this population. We found that 60.4% of these patients had positive prick-by-prick skin tests, being the most frequently involved families of foods: rosaceae (60%), crustaceans (25%), musaceae (23%), actinidacea (21%), lauraceae (16%) and cucurbitaceae (16%). Only 5 patients presented adverse reactions with prick-by-prick skin tests, in 4 of the cases with grade 3 and grade 4 anaphylaxis, while testing with banana-watermelon, peach, papaya and peanut, respectively., Conclusions: Oral allergy syndrome affects more women than men, the most frequent comorbidities in patients with oral allergy syndrome are allergic rhinitis and asthma, thus, in patients with asthma and allergic rhinitis, sensitized to pollens we have to ask about symptoms suggestive of oral allergy syndrome.
- Published
- 2014
821. Where to prick the apple for skin testing?
- Author
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Vlieg-Boerstra BJ, van de Weg WE, van der Heide S, and Dubois AE
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- Adolescent, Adult, Aged, Food Hypersensitivity diagnosis, Food Hypersensitivity immunology, Humans, Middle Aged, Plant Proteins immunology, Young Adult, Allergens immunology, Antigens, Plant immunology, Malus adverse effects, Skin Tests
- Abstract
Mal d 1 is not equally distributed over the apple. We aimed to examine the influence of the location of pricking in the apple on prick-to-prick skin prick test (PTP) results. PTPs were performed in autumn 2007 and spring 2008, before the birch pollen season, in 32 Dutch adults with symptoms of oral allergy to fresh apple, using apples harvested in autumn 2007. PTPs with fresh intact and unpeeled Pink Lady, Golden Delicious, Elise, Santana and Modi apples were performed using material obtained from approximately 2 cm near the stalk (top), and the middle region. All PTP responses were greater when performed with apple material near the stalk than from the middle region. In 2007, these differences were statistically significant for Pink Lady, Golden Delicious and Elise, and in 2008, for Pink Lady and Modi. When performing PTPs, the apple should be pricked near the stalk rather than in the middle., (© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2013
- Full Text
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822. Dietary intervention for oral allergy syndrome as a treatment in orofacial granulomatosis: a new approach?
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Campbell H, Escudier MP, Brostoff J, Patel P, Milligan P, Challacombe SJ, Sanderson JD, and Lomer MC
- Subjects
- Adolescent, Adult, Aged, Ambrosia immunology, Artemisia immunology, Betula immunology, Child, Child, Preschool, Crohn Disease immunology, Cross Reactions immunology, Female, Follow-Up Studies, Food Hypersensitivity immunology, Granulomatosis, Orofacial classification, Humans, Hypersensitivity, Immediate immunology, Intradermal Tests, Latex Hypersensitivity immunology, Male, Middle Aged, Poaceae immunology, Pollen immunology, Prospective Studies, Rhinitis, Allergic, Seasonal immunology, Treatment Outcome, Young Adult, Food Hypersensitivity diet therapy, Granulomatosis, Orofacial diet therapy
- Abstract
Background: Orofacial granulomatosis (OFG) is a chronic granulomatous condition of the mouth, face and lips. Recent work demonstrates a high rate of atopy and silver birch sensitisation from skin prick testing (SPT). Oral allergy syndrome (OAS) is an acute oro-pharyngeal IgE mediated reaction, triggered by foods that cross react with pollens, most commonly silver birch. The aim of this study was to determine if patients with OFG and positive SPT to common OAS associated pollens responded to avoidance of cross reactive foods., Methods: Patients with OFG and positive SPT to silver birch, grass, mugwort, ragweed and latex were required to avoid cross reacting foods, for 6 weeks and, in those who responded, for a total of 12 weeks. All had standardized oral examinations and were given severity scores (SS) at each appointment., Results: Twenty two of 47 (47%) patients had one or more positive SPT and 13/22 completed 6 weeks on the diet. No difference was seen in SS between weeks 0 (14.62 ± 11.16) and 6 (13.31 ± 10.33; P = 0.656). Six of 14 (43%) had significantly improved SS (week 0; 19.17 ± 12.95, week 6; 10.83 ± 4.99, P = 0.027). Five completed 12 weeks and no further improvement was seen (week 6; 11 ± 5.57, week 12; 10.4 ± 9.94; P = 0.068). Two patients required no further treatments., Conclusions: On an intention to treat basis, only 2/14 patients improved and required no further intervention. Whilst this diet cannot be recommended routinely, the improvement seen in some patients raises questions about the role of OAS in patients with OFG., (© 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.)
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- 2013
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823. Comparison of results of skin prick tests (with fresh foods and commercial food extracts) and RAST in 100 patients with oral allergy syndrome
- Author
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Raffaella Ansaloni, M. Ispano, Claudio Ortolani, Elide A. Pastorello, and G.C. Magri
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Adult ,Male ,Allergy ,Adolescent ,Immunology ,Population ,Orange (colour) ,medicine.disease_cause ,Radioallergosorbent Test ,Allergen ,Oral allergy syndrome ,Vegetables ,Botany ,otorhinolaryngologic diseases ,Humans ,Immunology and Allergy ,Medicine ,Food science ,Angioedema ,Child ,education ,Skin Tests ,Mouth ,education.field_of_study ,medicine.diagnostic_test ,business.industry ,Radioallergosorbent test ,food and beverages ,Middle Aged ,medicine.disease ,respiratory tract diseases ,Fruit ,Hay fever ,Female ,Phadebas ,business ,Food Hypersensitivity - Abstract
One hundred adult patients with a history of oral allergy syndrome (OAS) after ingestion of fruits and vegetables, 77 patients with hay fever and 13 with skin prick tests and RAST positive to pollens but without seasonal symptoms, and 32 normal nonallergic control subjects, had Phadebas RAST and skin prick tests with commercial extracts (CSPT) and with fresh foods (FFSPT) to assess the reliability of these three tests. Sensitivity was better with FFSPT for carrot, celery, cherry, apple, tomato, orange, and peach; better with CSPT for peanut, pea, and walnut; and better with RAST for hazelnut. Specificity, negative predictive value, and positive predictive value of the three tests were determined for apple, carrot, hazelnut, orange, pea, peanut, and tomato. Specificity in the patient groups ranged between 40% (pea) and 100% (apple) for CSPT, between 61% (peanut) and 87% (carrot) for RAST, and between 42% (carrot) and 93% (peanut) for FFSPT. However, all tests were negative in the control group. Thus, false positive results may result from cross-reactivity with pollen allergens. The diagnostic accuracy of these tests in the population with OAS proved comparable for peanut, carrot, hazelnut, and pea. FFSPT proved more sensitive than CSPT or RAST in confirming a history of OAS to certain alimentary allergens, such as apple, orange, tomato, carrot, cherry, celery, and peach.
- Published
- 1989
824. Food Hypersensitivity in Patients with Pollen Allergy
- Author
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Hans Formgren, Nils E. Eriksson, and Eivor Svenonius
- Subjects
Adult ,Male ,Allergy ,medicine.medical_specialty ,Adolescent ,Immunology ,Grass pollen allergy ,Pollen Allergy ,Poaceae ,Trees ,Radioallergosorbent Test ,Oral allergy syndrome ,Botany ,otorhinolaryngologic diseases ,medicine ,Humans ,Immunology and Allergy ,In patient ,Child ,Aged ,Skin Tests ,business.industry ,Pruritus ,Incidence (epidemiology) ,digestive, oral, and skin physiology ,Rhinitis, Allergic, Seasonal ,food and beverages ,Middle Aged ,medicine.disease ,Food hypersensitivity ,Dermatology ,Child, Preschool ,Pollen ,Female ,business ,Food Hypersensitivity ,Fruit allergy - Abstract
Six hundred patients with pollen allergy answered a questionnaire about food hypersensitivity. Hypersensitivity to various nuts, fruits and roots was reported more often by patients with birch pollen allergy(70%) than be patients without birch pollen allergy (19%). The stronger the skin test reaction to birch pollen, the higher was the incidence of food hypersensitivity. A negative correlation was found between grass pollen allergy and food hypersensitivity. In the diagnosis of springtime hayfever, the presence of hypersensitivity to nuts, fruits and roots supports a diagnosis of birch pollen allergy.
- Published
- 1982
825. Hypersensitivity manifestations to the fruit mango.
- Author
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Sareen R and Shah A
- Abstract
The objectives of this study are 1) To review the published data and document the current knowledge on allergic manifestations to the fruit mango 2) To highlight the two distinct clinical presentations of hypersensitivity reactions caused by mango 3) To discuss the role of cross-reactivity 4) To increase awareness of potentially life threatening complications that can be caused by allergy to mango. An extensive search of the literature was performed in Medline/PubMed with the key terms "mango", "anaphylaxis", "contact dermatitis", "cross-reactivity", "food hypersensitivity", "oral allergy syndrome" and "urticaria". The bibliographies of all papers thus located were searched for further relevant articles. A total of 17 reports describing 22 patients were documented, including ten patients with immediate hypersensitivity reaction and twelve patients with delayed hypersensitivity reaction to mango. Ten of these patients (four with immediate reaction; six with delayed reaction) were from geographical areas cultivating mango, whereas twelve patients (six with immediate reaction; six with delayed reaction) were from the countries where large scale mango cultivation does not occur. The clinical features, pathogenesis and diagnostic modalities of both these presentations are highlighted. The fruit mango can cause immediate and delayed hypersensitivity reactions, as also "oral allergy syndrome". Although rare, it can even result in a life threatening event. Reactions may even occur in individuals without prior exposure to mango, owing to cross reactivity. It is imperative to recognize such a phenomenon early so as to avoid potentially severe clinical reactions in susceptible patients.
- Published
- 2011
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826. Recent advances in component resolved diagnosis in food allergy
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Magnus P. Borres, Motohiro Ebisawa, Nobuyuki Maruyama, and Sakura Sato
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0301 basic medicine ,lcsh:Immunologic diseases. Allergy ,medicine.medical_specialty ,Allergy ,Molecular allergology ,Cross Reactions ,medicine.disease_cause ,03 medical and health sciences ,0302 clinical medicine ,Allergen ,Oral allergy syndrome ,Food allergy ,Diagnosis ,Immune Tolerance ,Animals ,Humans ,Medicine ,Immunology and Allergy ,Medical prescription ,Eosinophilic esophagitis ,Intensive care medicine ,business.industry ,Oral food challenge ,Immunology in the medical area ,Component resolved diagnosis ,General Medicine ,Allergens ,Immunoglobulin E ,medicine.disease ,Allergen components ,030104 developmental biology ,030228 respiratory system ,Desensitization, Immunologic ,Food ,Immunologi inom det medicinska området ,Immunology ,Food allergen ,business ,Risk assessment ,lcsh:RC581-607 ,Food Hypersensitivity - Abstract
Due to the high prevalence of food allergic diseases globally there are increasing demands in clinical practice for managing IgE-mediated conditions. During the last decade, component resolved diagnostics has been introduced into the field of clinical allergology, providing information that cannot be obtained from extract-based tests. Component resolved data facilitate more precise diagnosis of allergic diseases and identify sensitizations attributable to cross-reactivity. Furthermore it assists risk assessment in clinical practice as sensitization to some allergenic molecules is related to persistence of clinical symptoms and systemic rather than local reactions. The information may also aid the clinician in prescription of oral immunotherapy (OIT) in patients with severe symptoms, and in giving advice on food allergen avoidance or on the need to perform food challenges. The use of allergen components is rapidly evolving and increases our possibility to treat food allergic patients with a more individual approach. Using molecular allergology, we can already now better diagnose, prognose and grade the food allergy. In summary, daily routine molecular allergy diagnostics offers a number of benefits that give us a higher diagnostic precision and allow for better management of the patient.
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827. Spectrum of allergens for Japanese cedar pollinosis and impact of component-resolved diagnosis on allergen-specific immunotherapy
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The high prevalence of Japanese cedar pollinosis in Japan is associated with a negative impact on the quality of life of patients, as well as significant loss of productivity among the workforce in early spring, thus representing a serious social problem. Furthermore, the prevalence is increasing, and has risen by more than 10% in this decade. Cry j 1 and Cry j 2 were identified as the major allergens in Japanese cedar pollen (JCP), and in 2004, the existence of other major and minor allergens were revealed by a combination of two- dimensional electrophoresis and immunoblotting analysis. Allergenome analysis identified a chitinase, a lipid transfer protein, a serine protease, and an aspartic protease as novel IgE-reactive allergens in patients with JCP allergy. Thaumatin-like protein (Cry j 3) was shown to be homologous to Jun a 3, a major allergen from mountain cedar pollen. Isoflavone reductase-like protein was also characterized in a study of a JCP cDNA library. The characterization of component allergens is required to clarify the sensitizer or cross-reactive elicitor allergens for component-resolved diagnosis (CRD). Increasing evidence from numerous clinical trials indicates that CRD can be used to design effective allergen-specific immunotherapy. In this review, we summarize the eight characterized JCP allergens and discuss the impact of CRD and characterization of novel allergens on allergen-specific immunotherapy.
828. Allergy to apple, carrot and potato in children with birch pollen allergy
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Sten Dreborg and Tony Foucard
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Allergy ,Adolescent ,Immunology ,Pollen Allergy ,Biology ,Skin sensitivity ,complex mixtures ,Trees ,Oral allergy syndrome ,Vegetables ,medicine ,Respiratory Hypersensitivity ,Immunology and Allergy ,Humans ,Child ,Prausnitz–Küstner test ,Skin Tests ,fungi ,food and beverages ,Skin test ,Allergens ,medicine.disease ,Birch pollen ,Horticulture ,Agronomy ,Child, Preschool ,Fruit ,bacteria ,Pollen ,Food Hypersensitivity ,Fruit allergy - Abstract
Skin sensitivity to apple, carrot and potato, clinically related to birch pollinosis was investigated. Different skin test techniques using fresh fruit were compared. A simple prick test (SPT) technique with a lancet piercing the apple peel just before pricking the skin was shown to be the most practical and to give reproducible results. The allergenic activity in apple was found to be heat labile and deteriorated during storage at room temperature. Apple, carrot, potato, hazelnut and birch reactivity was transferable in Prausnitz-Kustner test like IgE antibodies. SPT reactivity to fresh material from apple, carrot and potato was investigated in 174 children of whom 128 suffered from pollen allergy. Positive SPT results were obtained almost exclusively in children who were SPT positive to a birch pollen extract. Children who noticed clinical symptoms when eating apple, raw carrot or potato were found to have a significantly larger SPT reaction than children with a negative history.
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- 1983
829. Oral allergy syndrome (OAS): symptoms of IgE-mediated hypersensitivity to foods
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P.E. Parkes, David M. Kemeny, Maurice H. Lessof, P. L. Amlot, and Christopher B. Zachary
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Adult ,Male ,medicine.medical_specialty ,Allergy ,Adolescent ,Immunology ,medicine.disease_cause ,Dermatitis, Atopic ,Atopy ,Radioallergosorbent Test ,Oral allergy syndrome ,medicine ,Immunology and Allergy ,Humans ,Child ,Asthma ,Skin Tests ,business.industry ,Age Factors ,Rhinitis, Allergic, Seasonal ,Atopic dermatitis ,Syndrome ,Immunoglobulin E ,Middle Aged ,medicine.disease ,Dermatology ,Food intolerance ,Child, Preschool ,Female ,Irritation ,business ,Anaphylaxis ,Food Hypersensitivity - Abstract
Summary Eighty highly atopic patients were selected for study because they had either atopic eczema (fifty cases) or atopic reactivity to foods, as judged by a positive skin-prick test (thirty cases). In all, sixty-five out of eighty subjects (81%) described symptoms of some kind provoked by foods, but correspondingly positive skin tests were found in only half of these, thirty-three out of eighty (41%). The symptoms experienced by thirty-one of the thirty-three patients with positive skin tests were immediate in onset (within 1 hr) and were at first confined to the upper gastrointestinal tract, the most frequent symptoms being oral irritation and throat tightness. In a proportion of these patients, further symptoms such as urticaria, asthma or anaphylaxis developed following the initial oral symptoms, which suggested the term‘oral allergy syndrome’. In the absence of the oral allergy, symptoms such as asthma, urticaria, migraine or eczema starting later than 1 hr after food were seldom associated with positive skin tests. In the oral allergy syndrome, the characteristic symptoms (strong association with positive skin tests and RAST, time of onset and sites at which symptoms are expressed) suggest a causative relationship between exposure to food antigens and specific IgE-induced release of mediators. In cases of food intolerance that lack a characteristic symptom pattern and a positive skin test or radio-allergo-sorbent test, it seems appropriate to consider non-IgE-mediated causes.
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- 1987
830. Evidence for a lipid transfer protein as the major allergen of apricot
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Raffaella Ansaloni, Francesco Purello D’Ambrosio, Claudio Ortolani, Valerio Pravettoni, Federica Rivolta, Amedeo Conti, Cristoforo Incorvaia, Gabriella Giuffrida, Elisabetta Scibola, Laura Farioli, Elide A. Pastorello, Donatella Fortunato, Mara Monza, and Anders Bengtsson
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Adult ,Male ,Allergy ,Glycosylation ,Adolescent ,Immunoblotting ,Molecular Sequence Data ,Immunology ,medicine.disease_cause ,Immunoglobulin E ,Allergen ,Antigen ,Oral allergy syndrome ,medicine ,Humans ,Immunology and Allergy ,Amino Acid Sequence ,Rosales ,Peptide sequence ,Chromatography, High Pressure Liquid ,Plant Proteins ,biology ,Isoelectric focusing ,Allergens ,Antigens, Plant ,Middle Aged ,medicine.disease ,Fruit ,biology.protein ,Electrophoresis, Polyacrylamide Gel ,Female ,Isoelectric Focusing ,Carrier Proteins ,Plant lipid transfer proteins ,Food Hypersensitivity - Abstract
Background: Apricots are widely grown in Europe, and allergic reactions are becoming more common, especially oral allergy syndrome. Apricot belongs to the botanical subfamily of Prunoideae, which includes peach, the major allergen of which was identified as a 9-kd protein, a lipid transfer protein (LTP). Objective: The aim of the study was to evaluate the IgE reactivity pattern to an apricot extract in subjects with allergic reactions to apricot, as demonstrated by a positive oral challenge response. Methods: Thirty patients were investigated. All the patients displayed oral allergy syndrome (2 with systemic reactions) to apricot, with positive open food challenge responses, skin prick test responses, and serum-specific IgE antibodies to apricot. The IgE reactivity pattern to apricot extract was identified by using SDS-PAGE and immunoblotting. The major allergen, a 9-kd protein, was then purified by HPLC and characterized by periodic acid–Schiff stain, isoelectric point determination, and N-terminal amino acid sequencing. Results: The sera from all patients allergic to apricot recognized the 9-kd protein, whereas none of the other allergens, with molecular weights from 15 to 80 kd, acted as a major allergen. The 9-kd allergen has an isoelectric point of 8.7 and is not glycosylated. Determination of the N-terminal 34 amino acid sequence showed that it belongs to the LTP family, with a 94% homology with the LTP from peach. IgE blotting of the apricot extract was completely inhibited by the 9-kd purified LTP from peach. Conclusions: The major allergen of apricot is an LTP, which is highly cross-reactive with the LTP from peach. (J Allergy Clin Immunol 2000;105:371-7.)
831. Presence of allergenic proteins in different peach (Prunus persica) cultivars and dependence of their content on fruit ripening
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Valerio Pravettoni, Oreste V. Brenna, Laura Farioli, Elide A. Pastorello, and Carlo Pompei
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biology ,Rosaceae ,Immunoblotting ,food and beverages ,Ripening ,General Chemistry ,Allergens ,medicine.disease_cause ,biology.organism_classification ,medicine.disease ,Prunus ,Horticulture ,Allergen ,Oral allergy syndrome ,Fruits and vegetables ,Fruit ,Botany ,medicine ,Electrophoresis, Polyacrylamide Gel ,Cultivar ,Seasons ,General Agricultural and Biological Sciences ,Plant lipid transfer proteins ,Plant Proteins - Abstract
It has been reported that various cultivars of fruits and vegetables may present a different pattern for the contained allergens. Here, we report on the different content in allergenic proteins for different peach (Prunus persica) cultivars, sampled during two consecutive harvest seasons. Fruits from six cultivars of peaches were harvested fully ripe, and the proteins extracted from whole or chemically peeled fruits were analyzed by SDS-PAGE and immunoblotting. All the protein extracts from whole fruit contained a 9 kDa protein. This protein proved to be absent in the extracts taken from chemically peeled fruit. In four cultivars, this protein corresponds to the allergen Pru p3, a lipid transfer protein that causes the oral allergy syndrome (OAS) in sensitized people. In the following year, fruits from four of the six cultivars of peaches studied previously were harvested at different times, at one and two weeks before the commercial ripening time and when fully ripe, to ascertain whether the presence of the 9 kDa allergen might be related to the ripening process. Two cultivars out of four produced an intense allergenic band corresponding to a 9 kDa protein already two weeks before the commercial ripening date, while the others showed a progressive increment of the 9 kDa allergen during ripening.
832. Oral allergy syndrome in patients with airborne pollen allergy treated with specific immunotherapy
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Czarnecka-Operacz, M., Dorota Jenerowicz, and Silny, W.
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Adult ,Male ,Adolescent ,atopic dermatitis ,oral allergy syndrome ,immunotherapy ,Plant Extracts ,Rhinitis, Allergic, Seasonal ,Syndrome ,Allergens ,Middle Aged ,Asthma ,Treatment Outcome ,Desensitization, Immunologic ,Surveys and Questionnaires ,Humans ,Pollen ,Female ,Child ,Food Hypersensitivity ,Plant Proteins - Abstract
According to literature, approximately 20%-70% of patients sensitized to pollen allergens experience oral allergy syndrome (OAS) symptoms after eating raw fruits and vegetables. There is no standard treatment established for OAS except avoiding implicated food. However, in patients with airborne pollen allergy treated with specific immunotherapy (SIT), an improvement of OAS symptoms has been reported in 30% to even 84% of individuals examined. The aim of the present study was to evaluate the prevalence of OAS symptoms in patients with various manifestations of pollen airborne allergy (atopic dermatitis (AD), asthma, allergic rhinitis) treated with subcutaneous type of SIT. In addition, the most common patterns of cross-reactivity in OAS were analyzed and correlations between OAS symptoms and patient age, type of sensitizing pollen allergens and atopy manifestations investigated. Also, the relationship between SIT duration and clinical improvement of both OAS symptoms and pollen allergy symptoms was analyzed. The study included 57 patients with airborne allergy treated with allergen vaccination (60% male and 40% female). Allergic rhinitis was diagnosed in 71%, AD in 19%, AD and asthma in 4%, allergic rhinitis and asthma in 4%, and both AD and allergic rhinitis in 2% of study patients. Twenty-eight percent of study patients complained of overt symptoms of OAS (22% of allergic rhinitis patients and 27% of AD patients); 69% of the subjects presenting with OAS showed polyvalent airborne allergy to pollens and 31% were sensitized to only one group of pollen allergens (mostly grass pollens, tree pollens and mugwort pollens). There was no statistically significant correlation between the presence of OAS symptoms and patient diagnosis, patient age and type of allergen vaccination used. According to patients' opinion, SIT significantly improved oral symptoms in 50% of study patients, 44% reported no impact of SIT on OAS symptoms and 6% of patients observed worsening of OAS symptoms after unintentional ingestion of implicated food during the course of SIT. The study revealed OAS as a significant problem in patients sensitized to various pollen allergens. The results on OAS prevalence in atopic subjects (28%) were consistent with some literature data. There was clear association between OAS and polyvalent airborne allergy (69%). Cross-reactivity patterns were typical (for example, tree pollen allergy - intolerance of apples, carrots and potatoes; grass pollen allergy - intolerance of kiwi fruit and tomatoes). Questionnaire analysis indicated that subcutaneous SIT significantly alleviated OAS symptoms associated with ingestion of the responsible fruit and vegetables in half of study subjects. Further evaluation of the duration/persistence and stability of the phenomenon is planned for the future.
833. A qRT-PCR assay for the expression of all Mal d 1 isoallergen genes
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W. Eric van de Weg, Giulia Pagliarani, Stefano Tartarini, Marinus M J Smulders, Paul Arens, Roberta Paris, Giampaolo Ricci, Pagliarani G., Paris R., Arens P., Tartarini S., Ricci G., Smulders MMJ., and van de Weg E.
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Malus ,In silico ,Plant Science ,Biology ,medicine.disease_cause ,in-vivo ,bet v 1 ,l. borkh ,Allergen ,Oral allergy syndrome ,medicine ,cultivars ,Gene family ,PR-10 ,birch pollen ,Gene ,Plant Proteins ,Genetics ,major allergen mal-d-1 ,Reverse Transcriptase Polymerase Chain Reaction ,Methodology Article ,Apple allergy ,food ,apple malus-domestica ,food and beverages ,qRT-PCR ,fruit ,Allergens ,Antigens, Plant ,medicine.disease ,biology.organism_classification ,Plant Breeding ,Real-time polymerase chain reaction ,gene family ,ige-binding epitopes ,Primer (molecular biology) ,Erratum ,OAS ,Mal d 1 - Abstract
Background - A considerable number of individuals suffer from oral allergy syndrome (OAS) to apple, resulting in the avoidance of apple consumption. Apple cultivars differ greatly in their allergenic properties, but knowledge of the causes for such differences is incomplete. Mal d 1 is considered the major apple allergen. For Mal d 1, a wide range of isoallergens and variants exist, and they are encoded by a large gene family. To identify the specific proteins/genes that are potentially involved in the allergy, we developed a PCR assay to monitor the expression of each individual Mal d 1 gene. Gene-specific primer pairs were designed for the exploitation of sequence differences among Mal d 1 genes. The specificity of these primers was validated using both in silico and in vitro techniques. Subsequently, this assay was applied to the peel and flesh of fruits from the two cultivars 'Florina' and 'Gala'. Results - We successfully developed gene-specific primer pairs for each of the 31 Mal d 1 genes and incorporated them into a qRT-PCR assay. The results from the application of the assay showed that 11 genes were not expressed in fruit. In addition, differential expression was observed among the Mal d 1 genes that were expressed in the fruit. Moreover, the expression levels were tissue and cultivar dependent. Conclusion - The assay developed in this study facilitated the first characterisation of the expression levels of all known Mal d 1 genes in a gene-specific manner. Using this assay on different fruit tissues and cultivars, we obtained knowledge concerning gene relevance in allergenicity. This study provides new perspectives for research on both plant breeding and immunotherapy.
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834. [Untitled]
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Allergy ,education.field_of_study ,Hepatology ,business.industry ,Population ,Gastroenterology ,medicine.disease ,medicine.disease_cause ,Allergic inflammation ,Allergic sensitization ,Allergen ,Oral allergy syndrome ,Food allergy ,Immunology ,Eosinophil activation ,Medicine ,business ,education - Abstract
IgE-associated food allergy affects approximately 3% of the population and has severe effects on the daily life of patients—manifestations occur not only in the gastrointestinal tract but also affect other organ systems. Birth cohort studies have shown that allergic sensitization to food allergens develops early in childhood. Mechanisms of pathogenesis include cross-linking of mast cell– and basophil-bound IgE and immediate release of inflammatory mediators, as well as late-phase and chronic allergic inflammation, resulting from T-cell, basophil, and eosinophil activation. Researchers have begun to characterize the molecular features of food allergens and have developed chip-based assays for multiple allergens. These have provided information about cross-reactivity among different sources of food allergens, identified disease-causing food allergens, and helped us to estimate the severity and types of allergic reactions in patients. Importantly, learning about the structure of disease-causing food allergens has allowed researchers to engineer synthetic and recombinant vaccines.
835. Assessment of oral allergy syndrome in patients with seasonal allergic rhinitis by food challenge test
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Farahzad Jabbari Azad, Afshin Shirkani, and Reza Faridhosseini
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lcsh:R5-920 ,Food Challenge Test ,Oral allergy syndrome ,seasonal allergic rhinitis ,lcsh:Medicine (General) - Abstract
Background: Oral allergy syndrome (OAS) characterized by oral IgE-mediated symptoms, which is caused by cross-reactivity between proteins in pollens, fresh fruit and vegetables. OAS is presents in 40% to 80% of Allergic rhinitis patients. Association between oral allergy syndrome and duration of seasonal allergic rhinitis is not well known. Early treatment of Patients with OAS caused improvement in quality of life and relief of their symptoms. Material and methods: In this prospective cross-sectional study between March 2012 to September 2012, 103 consecutive patients with seasonal allergic rhinitis were entered to this study. Their sensitizations to common aeroallergens were confirmed by skin prick test (SPT) by three mm more than negative control. According to food allergy history and prick-to-prick test results, we considered 63 of 103 patients for single-blind oral food challenge test. Data analyzed bty SPSS software (ver 11.5), and by Chi squeare test and paired T test. P-value lower than 0.05 was considered as significant. Results: Among studied cases, 63 patients (61.2%) with 28.8±10.6 years old had OAS and 40 (38.8%) with 26.8±13.2 years old not OAS. We found that there was significant difference between duration of seasonal allergic rhinitis in OAS group (7±5.9 years) and non-OAS group (5±4 years) (P=0.03, CI=0.03-0.04). This syndrome was more in women and patients who had concomitant asthma and allergic conjunctivitis but statistical association was not significant. Conclusions: This study showed that all of the patients with hay fever do not develop OAS. Duration of seasonal allergic rhinitis was associated significantly with oral allergy syndrome. However, further studies with more sample size and double-blind placebo controlled methods might be needed.
836. [Untitled]
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Immunoglobulin A ,Allergy ,biology ,business.industry ,Immunology ,Context (language use) ,medicine.disease ,medicine.disease_cause ,Immunoglobulin E ,Immunoglobulin G ,Allergen ,Oral allergy syndrome ,Food allergy ,medicine ,biology.protein ,Immunology and Allergy ,business - Abstract
About 70% of patients allergic to birch pollen (BP) show IgE-mediated reactions to plant foods such as hazelnut, apple, stone fruits, kiwi, carrot, celeriac and soya bean, typically mild reactions of the upper oral cavity, termed oral allergy syndrome (OAS) 1. These food allergies are a consequence of sensitization to Bet v 1 and subsequent IgE and T-cell cross-reactivity with homologous food allergens 2,3, such as Cor a 1.04 4, Mal d 1 5, Pru p 1 6, Api g 1 7,8 and Gly m 4 9. These allergens possess high sequence and structural identities with Bet v 1 10,11. Nearly all BP-allergic patients are sensitized to Bet v 1 12,13 and are at risk of developing plant food allergy 14. However, most patients show allergic reactions only to a limited number of potentially allergenic foods. Moreover, IgE specific to a certain Bet v 1-related allergen does not predict a clinically manifest allergy 15. The factors that determine the clinical spectrum of Bet v 1-associated plant food allergy are mostly unknown. In contrast to IgE, Bet v 1-specific antibodies of other isotypes were less frequently investigated. Some patients undergoing allergen-specific immunotherapy (IT) develop blocking IgG which inhibits binding of allergens to IgE 16. Moreover, IgG4, IgG4/IgE ratios and IgG4 blocking activity were associated with tolerance to hazelnut and apple among Bet v 1-sensitized patients 13. Few studies examining the role of allergen-specific IgA have been published. The levels of Bet v 1-specific IgA in nasal fluids of BP-allergic children increased during the pollen season, albeit with unclear clinical relevance 17. Examinations of the significance of IgA for the development of natural or induced tolerance in milk- or egg-allergic children showed no correlation 18,19. Hence, we aimed to determine whether potentially tolerance-inducing allergen-specific IgG and IgA antibodies have an influence on the clinical activity of allergen-specific IgE. To this end, we used a panel of sera from well-characterized BP-allergic patients with individual patterns of plant food allergies to measure IgE, IgG1, IgG4 and IgA levels specific to Bet v 1-related allergens from hazelnut, peach, apple, soya, mung bean and celeriac. Moreover, we compared these concentrations with clinical symptoms to evaluate the significance of the different Ig classes in context with allergy or tolerance.
837. Food allergy in gastroenterologic diseases: Review of literature
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Maria Esposito-Pellitteri, Giuseppe Montalto, Pasquale Mansueto, Stefania Maria Leto-Barone, Maria Luisa Pacor, Claudia Lo Bianco, Gabriele Di Lorenzo, Vito Ditta, Mansueto, P., Montalto, G., Pacor, M., ESPOSITO PELLITTERI, M., Ditta, V., LO BIANCO, C., LETO BARONE, S., and DI LORENZO, G.
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medicine.medical_specialty ,Allergy ,Settore MED/09 - Medicina Interna ,Epinephrine ,Gastrointestinal Diseases ,Food allergy ,gastroenterologic diseases ,Population ,Review ,Immunoglobulin E ,Oral allergy syndrome ,medicine ,Humans ,Adverse effect ,education ,Anaphylaxis ,Skin Tests ,education.field_of_study ,biology ,business.industry ,Oral food challenge ,digestive, oral, and skin physiology ,Gastroenterology ,General Medicine ,medicine.disease ,Dermatology ,Immunology ,Histamine H1 Antagonists ,biology.protein ,Immunotherapy ,business ,Food Hypersensitivity - Abstract
Food allergy is a common and increasing problem worldwide. The newly-found knowledge might provide novel experimental strategies, especially for laboratory diagnosis. Approximately 20% of the population alters their diet for a perceived adverse reaction to food, but the application of double-blind placebo-controlled oral food challenge, the “gold standard” for diagnosis of food allergy, shows that questionnaire-based studies overestimate the prevalence of food allergies. The clinical disorders determined by adverse reactions to food can be classified on the basis of immunologic or nonimmunologic mechanisms and the organ system or systems affected. Diagnosis of food allergy is based on clinical history, skin prick tests, and laboratory tests to detect serum-food specific IgE, elimination diets and challenges. The primary therapy for food allergy is to avoid the responsible food. Antihistamines might partially relieve oral allergy syndrome and IgE-mediated skin symptoms, but they do not block systemic reactions. Systemic corticosteroids are generally effective in treating chronic IgE-mediated disorders. Epinephrine is the mainstay of treatment for anaphylaxis. Experimental therapies for IgE-mediated food allergy have been evaluated, such as humanized IgG anti-IgE antibodies and allergen specific immunotherapy.
838. Introducing chemists to food allergy
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Claudio Ortolani, Joseph Scibilia, M. Ispano, and Elide A. Pastorello
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Allergy ,Food industry ,business.industry ,digestive, oral, and skin physiology ,Immunology ,Atopic dermatitis ,Allergens ,medicine.disease ,medicine.disease_cause ,Allergen ,Oral allergy syndrome ,Food allergy ,medicine ,Food processing ,Prevalence ,Immunology and Allergy ,Humans ,business ,Anaphylaxis ,Food Hypersensitivity - Abstract
Adverse reactions to food may be toxic or non toxic, depending on the susceptibility to a certain food; non toxic reactions that involve immune mechanisms are termed allergy if they are IgE-mediated. If no immunological mechanism is responsible, it is termed intolerance. The following disorders are considered a consequence of food allergy: gastrointestinal reactions (oral allergy syndrome, vomiting, diarrhea, protein-induced enterocolitic syndrome, eosinophilic gastroenteritis); respiratory reactions (rhinitis, asthma, laryngeal edema); cutaneous reactions (urticaria-angioedema, atopic dermatitis); anaphylaxis. There is much recent evidence to consider celiac disease an immunological disorder. Food allergy diagnosis is based on history, SPT, specific IgE, food challenges. DBPCFC is fundamental for diagnosing true food allergy; patients who have had anaphylaxis to food must not undergo DBPCFC. Rapidly progressive respiratory reactions and anaphylactic shock are life-threatening reactions that can be caused by food allergy. The doses of food inducing anaphylaxis can be very low, therefore commercial cross-contamination with an unsuspected food during food processing can be risky for the food allergic patient. The prevention of severe anaphylactic food reactions may lie in interdisciplinary collaboration among allergologists, chemists, food technologists, and experts in food industry research.
839. 日本の小児における口腔アレルギー症候群の有病率の地域差についてのアンケート調査
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Ota, Masaya
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child ,allergic rhinitis ,fungi ,prevalence ,pollen-food allergy syndrome ,oral allergy syndrome - Abstract
Background: Oral allergy syndrome (OAS) is characterized by an immediate allergic reaction that mainly or partially affects the oral mucosa, pharynx, or lips, and it is usually caused by ingesting fresh fruits or vegetables. Most patients with OAS also have allergic rhinitis due to pollen. As allergic rhinitis is increasingly prevalent in the Japanese population and the age at disease development is decreasing, morbidity associated with OAS among the younger population is likely to increase. However, there is little information about the prevalence of this disease among Japanese children, specifically the influences of residency in regions with different environments. Objectives: To investigate the prevalence of OAS and seasonal allergic rhinitis (SAR) among Japanese children and evaluate the relationship between OAS and SAR. Methods: We administered a questionnaire-based survey among children aged 7–15 years, living in 4 cities in central Japan. Results: The questionnaires were administered to 4103 children and completed by 3365 (82.0%). Overall, 524 children (15.6%) reported OAS-like symptoms after ingesting fruits or vegetables. The prevalence of seasonal SAR and oral symptoms significantly differed among the 4 cities. The total prevalence of oral symptoms co-occurring with SAR was 24.4%, which was significantly higher than the prevalence of symptoms occurring without SAR (10.2%, p < 0.001). Conclusion: Herein, oral symptoms were more likely to occur in patients with SAR than in those without SAR. The prevalence of SAR and food-induced oral symptoms significantly differed among the regions, suggesting they might be affected by regional differences in lifestyles and flora., Asian Pacific Journal of Allergy and Immunology. 2020., 新大院博(医)第990号
840. Oral allergy syndrome - the need of a multidisciplinary approach
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Kelava N, Lugović-Mihić L, Duvancić T, Romić R, and Mirna Situm
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Food hypersensitivity ,Mouth diseases – immunology ,Oral allergy syndrome ,Pollen ,food and beverages - Abstract
Oral allergy syndrome (OAS) is one of the most common types of food allergy. The syndrome includes itching and swelling of the lips, palate and tongue, usually after consuming fresh fruits and vegetables. The underlying pathogenic mechanism is cross-reactivity between IgE antibodies specific to pollen, and antigens in food, such as fresh fruits, vegetables and nuts that are structurally similar to pollen. Both pollen and food antigens can bind to IgE and trigger type I immune reaction. Diagnosis is primarily based on the patient’s history, and confirmed by skin tests, in vitro tests, and oral provocation tests. Differential diagnoses include many diseases (such as burning mouth syndrome, angioedema, hay fever, various other oral diseases, etc.), and for this reason a multidisciplinary approach is necessary, as different specialists need to be involved in the diagnostic procedure. Therapy includes avoiding, or thermal processing of, fruit and vegetables known to trigger a reaction, and antihistamine medications. If a more severe anaphylactic reaction develops, more aggressive therapy is required. The goal of this article is to present OAS, its etiopathogenesis, clinical picture, and symptoms, diagnostic approach and therapy for OAS.
841. The basophil activation test reflects the severity and the threshold of allergic reactions to peanut – a double-blind-placebo-controlled peanut challenge study
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Gideon Lack, Victor Turcanu, Abdel Douiri, Suzana Radulovic, Alick Stephens, Alexandra F. Santos, and George Du Toit
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Pulmonary and Respiratory Medicine ,Allergy ,CD63 ,business.industry ,Immunology ,Peanut allergy ,food and beverages ,Basophil ,medicine.disease ,Placebo ,Basophil activation ,medicine.anatomical_structure ,Oral allergy syndrome ,Poster Presentation ,medicine ,Immunology and Allergy ,business ,Anaphylaxis - Abstract
Results 44 peanut allergic children (median age 5 years) reacted to peanut on DBPCPC with clinical symptoms than ranged from oral allergy syndrome to anaphylaxis. 61% of patients reacted to 0.1g of peanut protein. The mean %CD63+ basophil at 10 and 100 ng/ml of PE was independently associated with severity (p=0.012) whilst CD-sens (1/EC50x100) was independently associated with threshold (p=0.039) of allergic reactions to peanut. Severity and threshold parameters were correlated both at the clinical (Rs=-0.38; p=0.013) and at the basophil level (Rs=0.65; p
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842. O11 - Cor a 14: the missing link in the molecular diagnosis of hazelnut allergy?
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Margo M. Hagendorens, Luc S. De Clerck, Chris H. Bridts, Vito Sabato, Catharina M. Van der Heijden, Maaike De Graag, Didier G. Ebo, and Margaretha A. Faber
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Pulmonary and Respiratory Medicine ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Pediatrics ,Allergy ,Immunology ,Population ,Gastroenterology ,Ige reactivity ,Oral allergy syndrome ,Internal medicine ,medicine ,Immunology and Allergy ,cardiovascular diseases ,education ,Sensitization ,education.field_of_study ,business.industry ,food and beverages ,Atopic dermatitis ,respiratory system ,medicine.disease ,respiratory tract diseases ,Systemic reaction ,medicine.anatomical_structure ,Hazelnut allergy ,Oral Presentation ,business - Abstract
Results Thirty-seven patients suffered from a systemic reaction and 38 patients reported an oral allergy syndrome (OAS) after eating hazelnut. In the population with systemic reactions, sensitization to Cor a 14 was seen in 19/20 preschoolchildren (median age (range) 2.6 years (1.0 – 5.4)), 8/10 schoolchildren (10.2 years (8.0 – 13.8 )) and 2/7 adults (28 years (18 – 33)) whereas sensitization to Cor a 9 was observed in 16/20 preschoolchildren, 7/10 schoolchildren and 3/7 adults. A minority of 13/37 and 5/37 was sensitized to Cor a 11 and Cor a 8. Combining of Cor a 14 and Cor a 9 enables us to correctly diagnose respectively 100 %, 80 % and 43 % of systemic reactions in preschool-, schoolchildren and adults. In contrast sensitization to Cor a 1.04 was generally associated with OAS, IgE reactivity to Cor a 1.04 was observed in respectively 6/7, 8/9 and 22/22 of preschool, schoolchildren and adults. Sensitization to Cor a 14 was seen in two patients with OAS, although these sIgE levels to Cor a 14 were significantly lower. Twenty-one percent of the infants with AD showed Cor a 14 sensitization, whereas 4/14 and 1/14 showed IgE reactivity to Cor a 9 and Cor a 11.
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843. Anaphylaxis in an infant to raw potato
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Özkan Karaman, Pınar Uysal, Fatih Firinci, Nevin Uzuner, Tuba Tuncel, Zeynep Arikan Ayyildiz, and Şenol Alan
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Pulmonary and Respiratory Medicine ,Allergy ,business.industry ,Immunology ,RC581-607 ,medicine.disease ,respiratory tract diseases ,Birch pollen ,Oral allergy syndrome ,immune system diseases ,Poster Presentation ,Immunology and Allergy ,Medicine ,Weaning ,Immunologic diseases. Allergy ,business ,Contact dermatitis ,Anaphylaxis ,Asthma - Abstract
Potato was believed to have a lower allergenic potential and it was the one of the first preferred food for weaning period in infancy. To date, the allergenic reactions are mostly reported in adults including oral allergy syndrome, contact dermatitis, exacerbations of asthma, and rarely anaphylaxis.
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844. Sensitisation pattern to birch pollen allergen components in oral allergy syndrome to Rosaceae fruits in patients with spring pollinosis from an East European Sylvosteppe area with low density forests
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Adriana Mihaela Tudose, Florin-Dan Popescu, Mariana Vieru, and Nicolae Viorel Dumitrescu
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Pulmonary and Respiratory Medicine ,Betulaceae ,PEAR ,Allergy ,biology ,Traditional medicine ,business.industry ,Rosaceae ,Immunology ,digestive, oral, and skin physiology ,food and beverages ,medicine.disease_cause ,biology.organism_classification ,medicine.disease ,Fagales ,Horticulture ,Allergen ,Oral allergy syndrome ,Pollen ,Poster Presentation ,medicine ,otorhinolaryngologic diseases ,Immunology and Allergy ,business - Abstract
Methods We evaluated subjects from Southern Romania, a Central European region with temperate continental climate with submediterranean and humid subtropical influences, where sensitization to Betulaceae pollen is less important in pollinosis compared with that to grass or weed pollen. We selected adult patients from the region of sylvosteppe with low density forests dominated by deciduous species, presenting symptoms of rhinoconjunctivitis in March to May and oral allergy syndrome to fresh Rosaceae fruits, allergic reactions in the mouth and throat without systemic symptoms, and having positive skin prick tests to Betulaceae tree pollen and positive prick-to-prick skin tests with fresh intact and unpeeled apple, pear, apricot, peach, cherry or plum. Because allergen components present in Fagales tree pollen and Rosaceae fruits are PR-10 proteins, profilins and isoflavone reductases, we measured the serum levels of specific IgE to European birch pollen and to recombinant allergen components Bet v1 (birch major PR-10 allergen with ribonuclease activity), Bet v2 (birch-pollen profilin), and Bet v6 (birch-pollen isoflavone reductase), using a multiparameter immunoblot test system based on single purified allergen components (SPAC 1).
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845. Identification of Helianthus annuus allergens in subjects with allergy to sunflower
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Araceli Díaz-Perales, Mª Luisa Macias, Natalia Blanca-López, Francisca Gómez, M. J. Torres, Ana Aranda, Cristobalina Mayorga, Gabriela Canto, and Miguel Blanca
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Pulmonary and Respiratory Medicine ,business.industry ,Immunology ,Albumin ,food and beverages ,Pharmacology ,Basophil ,medicine.disease ,Sunflower ,Basophil activation ,medicine.anatomical_structure ,Oral allergy syndrome ,Food allergy ,Helianthus annuus ,Poster Presentation ,medicine ,Immunology and Allergy ,Sunflower seed ,business - Abstract
Background Sunflower seeds (Helianthus annuus) can trigger anaphylactic reactions, generalized urticaria, angioedema, oral allergy syndrome and other symptoms after ingestion. These reactions have been attributed to 2S albumins (SFA-8) and LTP (Hel a 3). We aimed to characterize the basophil response to storage proteins and oleosins from sunflower seed in patients allergic to sunflower. Methods The proteins 2S, 11S and oleosins were purified from a raw sunflower seed extract by FPLC/HPLC and identified by specific antibodies and peptide mass fingerprinting. We tested the immunological recognition of these proteins by basophil activation test (BAT). Four concentrations (1, 0.2, 0.1, 0.02 ig/ml) of each protein and the sunflower roasted extract were used. Ten patients were selected by clinical history and skin prick test positive to commercial extract. Twelve subjects with skin prick test negative to commercial extract and not food allergy were included as controls. Results All patients showed a positive basophil response to roasted extract. BAT was positive in 87.5% of cases for 2S albumin, 60% for oleosins, and 57.14% for 11S albumin. 50% of patients were positive to the 3 proteins, 37.5% only for 2S albumin and 12.5% for storage proteins (both 2S and 11S albumin). In 40% of controls the concentration 1 ig/ml of 2S albumin induced low basophil activation. Conclusions
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846. Oral allergy syndrome
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Luciana Canela
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Allergy ,business.industry ,Immunology ,Pharynx ,Specific immunotherapy ,medicine.disease ,Oral cavity ,Dermatology ,medicine.anatomical_structure ,Oral allergy syndrome ,Meeting Abstract ,medicine ,Itching ,Exclusion diet ,Immunology and Allergy ,medicine.symptom ,business ,Positive skin test - Abstract
Results L.V.C.L., female, 12 years old, from Rio de Janeiro, Brazil, was attended in march 2012 at the clinic of Allergy and Immunology, with moderate persistent rhinitis. She had a positive skin test to Dermatophagoides pteronyssinus and specific immunotherapy was started. In September 2012, patient reported severe itching in the oral cavity and pharynx when eating lettuce. She denied symptoms similar to any other food. In dezembro 2012, was performe “prick to prick” for lettuce, with the following result: histamine=7mm; negative control=0mm and lettuce=9 mm. Patient was instructed not to eat lettuce. The test was confirmed on another occasion and was also performed in the patient’s grandmother, who did not have a history of reaction to lettuce, with the same lettuce tested in the patient, to exclude the presence of irritants as a cause of positive skin test. The result of patient’s grandmother was: histamine=5 mm; negative control=0mm and lettuce=0mm. In May 2013, was performed RAST (radioallergosorbent) test for lettuce and result was negative. The patient was advised to maintain an exclusion diet of lettuce but she decided to eat lettuce on their own. By eating organic and non-organic lettuce, the patient presented severe oropharyngeal pruritus, as reported in future consultations.
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847. Profilin desensitisation in patients with adverse reaction after plant-derived: our experience
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Manuela Ferraironi, Simona Mezzacappa, Eleonora Nucera, Alessia Di Rienzo, Domenico Schiavino, Michele Centrone, Valentina Pecora, Angela Rizzi, Anna Giulia Ricci, Alessandro Buonomo, Lucilla Pascolini, and Arianna Aruanno
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Pulmonary and Respiratory Medicine ,Allergy ,biology ,business.industry ,medicine.medical_treatment ,Immunology ,macromolecular substances ,medicine.disease ,Immunoglobulin E ,Basophil activation ,Oral allergy syndrome ,Profilin ,medicine ,biology.protein ,Oral Presentation ,Immunology and Allergy ,Ingestion ,Adverse effect ,business ,Desensitization (medicine) - Abstract
Profilins constitute a family of highly conserved proteins, which are present in all eukaryotic cells and are involved in processes related to cell motility. The first allergenic profilin was described in birch pollen and was designated Bet v 2. Allergenic profilin were identified in tree and grass pollens, in weeds, in plant-derived foods, as well as in latex. Due to conserved structure of the profilins, specific IgE may cross-react with homologues from virtually every plant source. Therefore, profilin sensitization is a risk factor for allergic reactions to multiple pollen and food allergen sources. Profilins are randomly distributed in pulp and peel and they are labile to heat denaturation and pepsin digestion. In fact the ingestion of vegetables in profilin sensitized patients usually determines reactions restricted to the oral cavity (oral allergy syndrome, OAS), despite in literature systemic reactions to zucchini and litches are reported. We describe the history of six patients with adverse reactions after eating plant-derived food and positive allergological evaluation (skin tests, specific IgE, basophil activation test and double-blind placebo-control challenges (DBPCFC) for profilin, that have been undergone to desensitization treatment. The protocol of desensitization started with a drop of profilin solution (50 µg/ml) diluted 1:1018 in water until the highest dose of 10 drops of undiluted solution three times a week. They underwent this desensitization treatment at home and were followed in Day Hospital regimen monthly. According to the protocol they were trained in medical treatment of allergic reactions and equipped with an emergency kit: autoinjectable epinephrine, betamethasone and clorphenamine. At the end of the treatment all patients had negative DBPCFCs with culprit foods and a decrease of specific IgE levels for profilin and vegetable foods. Moreover, the desensitization with profilin has proved to be safe as no serious adverse events were observed in our patients. Profilin desensitization allowed that our patients could manage their diet without restriction, eating several foods previously not tolerated.
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848. Leguminous allergy in a sample of children attending an outpatient allergy clinic
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Joana Extreia, Pedro Martins, Paula Leiria-Pinto, E. Finelli, and Joana Belo
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Allergy ,Pediatrics ,Allergic reaction ,business.industry ,Immunology ,Mucocutaneous zone ,food and beverages ,medicine.disease ,Dermatology ,Oral allergy syndrome ,Food allergy ,Concomitant ,Poster Presentation ,medicine ,Immunology and Allergy ,Age of onset ,business ,Anaphylaxis - Abstract
Results The median age of onset of the allergic reaction was 3.9 ± 2.2 years. The leguminous most commonly responsible for allergy were the peas involved in 5 reactions, followed by chickpeas and beans, each involved in three reactions. All children were allergic to more than one leguminous, with a median of two leguminous involved in allergic reactions. All reactions except for one were immediate with a mild to severe degree of severity. Regarding the clinical findings of the allergic reactions, the mucocutaneous, gastrointestinal and respiratory symptoms occurred with similar frequency. Oral allergy syndrome was seen in one reaction. Two of these reactions fulfilled anaphylaxis criteria. All children except for one were allergic to at least another class of food besides the leguminous. Concomitant allergic rhinitis was also seen in all patients except for one. SPT, namely prick to prick tests, were performed and confirmed the allergy in all patients.
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849. Allergic diseases of the skin and drug allergies – 2012. Is there association between duration of seasonal alleric rhinitis and oral allergy syndrome?
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Mohammad Reza Zandkarimi, Farahzad Jabbari, Hadis Yousefzadeh, Reza Faridhosseini, and Afshin Shirkani
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Pulmonary and Respiratory Medicine ,Pediatrics ,medicine.medical_specialty ,Allergy ,business.industry ,Cross-sectional study ,Oral food challenge ,Immunology ,Aeroallergen ,medicine.disease ,medicine.disease_cause ,Dermatology ,Atopy ,medicine.anatomical_structure ,Oral allergy syndrome ,Food allergy ,Meeting Abstract ,Medicine ,Immunology and Allergy ,business ,Sensitization - Abstract
Methods In this cross sectional study, 103 consecutive patients with seasonal allergic rhinitis were enrolled. Sensitization to common aeroallergen confirmed by skin prick test 3 millimeter more than negative control. Clinical symptoms, personal and familial history of atopy and demographic data were listed. According to food allergy history 63 of 103 patients had positive Open SingleBlind Oral Food Challenge Test that was associated with oral allergy syndrome.
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