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Dietary intervention for oral allergy syndrome as a treatment in orofacial granulomatosis: a new approach?
- Source :
-
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology [J Oral Pathol Med] 2013 Aug; Vol. 42 (7), pp. 517-22. Date of Electronic Publication: 2013 Jan 09. - Publication Year :
- 2013
-
Abstract
- Background: Orofacial granulomatosis (OFG) is a chronic granulomatous condition of the mouth, face and lips. Recent work demonstrates a high rate of atopy and silver birch sensitisation from skin prick testing (SPT). Oral allergy syndrome (OAS) is an acute oro-pharyngeal IgE mediated reaction, triggered by foods that cross react with pollens, most commonly silver birch. The aim of this study was to determine if patients with OFG and positive SPT to common OAS associated pollens responded to avoidance of cross reactive foods.<br />Methods: Patients with OFG and positive SPT to silver birch, grass, mugwort, ragweed and latex were required to avoid cross reacting foods, for 6 weeks and, in those who responded, for a total of 12 weeks. All had standardized oral examinations and were given severity scores (SS) at each appointment.<br />Results: Twenty two of 47 (47%) patients had one or more positive SPT and 13/22 completed 6 weeks on the diet. No difference was seen in SS between weeks 0 (14.62 ± 11.16) and 6 (13.31 ± 10.33; P = 0.656). Six of 14 (43%) had significantly improved SS (week 0; 19.17 ± 12.95, week 6; 10.83 ± 4.99, P = 0.027). Five completed 12 weeks and no further improvement was seen (week 6; 11 ± 5.57, week 12; 10.4 ± 9.94; P = 0.068). Two patients required no further treatments.<br />Conclusions: On an intention to treat basis, only 2/14 patients improved and required no further intervention. Whilst this diet cannot be recommended routinely, the improvement seen in some patients raises questions about the role of OAS in patients with OFG.<br /> (© 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.)
- Subjects :
- Adolescent
Adult
Aged
Ambrosia immunology
Artemisia immunology
Betula immunology
Child
Child, Preschool
Crohn Disease immunology
Cross Reactions immunology
Female
Follow-Up Studies
Food Hypersensitivity immunology
Granulomatosis, Orofacial classification
Humans
Hypersensitivity, Immediate immunology
Intradermal Tests
Latex Hypersensitivity immunology
Male
Middle Aged
Poaceae immunology
Pollen immunology
Prospective Studies
Rhinitis, Allergic, Seasonal immunology
Treatment Outcome
Young Adult
Food Hypersensitivity diet therapy
Granulomatosis, Orofacial diet therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0714
- Volume :
- 42
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 23297760
- Full Text :
- https://doi.org/10.1111/jop.12041