Search

Your search keyword '"orofacial cleft"' showing total 408 results
Start Over Descriptor "orofacial cleft"
408 results on '"orofacial cleft"'

401. Modeling anterior development in mice: diet as modulator of risk for neural tube defects.

Author

Kappen C

Subjects
Anencephaly genetics, Anencephaly metabolism, Anencephaly physiopathology, Animals, Cleft Lip genetics, Cleft Lip metabolism, Cleft Lip physiopathology, Cleft Palate complications, Cleft Palate genetics, Cleft Palate mortality, Diabetes, Gestational genetics, Diabetes, Gestational metabolism, Diabetes, Gestational physiopathology, Dietary Supplements, Disease Models, Animal, Female, Gene-Environment Interaction, Humans, Mice, Neural Tube Defects physiopathology, Pregnancy, Folic Acid metabolism, Maternal Nutritional Physiological Phenomena, Morphogenesis, Neural Tube Defects metabolism
Abstract

Head morphogenesis is a complex process that is controlled by multiple signaling centers. The most common defects of cranial development are craniofacial defects, such as cleft lip and cleft palate, and neural tube defects, such as anencephaly and encephalocoele in humans. More than 400 genes that contribute to proper neural tube closure have been identified in experimental animals, but only very few causative gene mutations have been identified in humans, supporting the notion that environmental influences are critical. The intrauterine environment is influenced by maternal nutrition, and hence, maternal diet can modulate the risk for cranial and neural tube defects. This article reviews recent progress toward a better understanding of nutrients during pregnancy, with particular focus on mouse models for defective neural tube closure. At least four major patterns of nutrient responses are apparent, suggesting that multiple pathways are involved in the response, and likely in the underlying pathogenesis of the defects. Folic acid has been the most widely studied nutrient, and the diverse responses of the mouse models to folic acid supplementation indicate that folic acid is not universally beneficial, but that the effect is dependent on genetic configuration. If this is the case for other nutrients as well, efforts to prevent neural tube defects with nutritional supplementation may need to become more specifically targeted than previously appreciated. Mouse models are indispensable for a better understanding of nutrient-gene interactions in normal pregnancies, as well as in those affected by metabolic diseases, such as diabetes and obesity., (© 2013 Wiley Periodicals, Inc.)

Published
2013
Full Text
View/download PDF

402. Maternal nutritional status affects fetal risk of developing orofacial cleft.

Abstract

Focuses on the significance of periconceptional folate and folic acid intake in preventing orofacial clefts (OFC) in the offspring. Investigation of the preconceptional intake of macronutrients, vitamins, minerals, and food groups in mothers of OFC children; Detection of lower intake of nutrients by OFC mothers; Importance of increasing intakes of vegetable protein, fiber, ascorbic acid, iron, and magnesium in decreasing OFC risk.

Published
2005

403. Orofacial clefts and risk factors in tehran, iran: a case control study.

Author

Taghavi N, Mollaian M, Alizadeh P, Moshref M, Modabernia Sh, and Akbarzadeh AR

Abstract

Background: Non-syndromic cleft lip with or without cleft palate (CL/P) or cleft palate only (CPO) are orofacial clefts with multifactorial etiology. These include environmental factors and heterogeneous genetic background. Therefore, studies on different and homogenous populations can be useful in detecting related factors. The aim of the present study was to evaluate the risk factors in patients with non-syndromic cleft in Tehran, Iran., Methods: Data from 300 patients and 300 controls were collected between 2005 and 2010. Binary logistic regression analyses were used to calculate relative risk by odds ratio (OR) and %95 confidence interval., Results: Low maternal age (OR=1.06, 95% CI, 1.011-1.113), low socioeconomic status (OR=0.23, 95% CI, 0.007-0.074), maternal systemic disease (OR=0.364; 95% CI, 0.152-0.873) and passive smoking (OR=0.613, 95% CI, 0.430-0.874) increased the risk for CL/P and CPO. There was a significant difference in iron and folic acid use during pregnancy when the case and control groups were compared., Conclusion: In assessing for orofacial cleft risk, we should consider lack of folic acid supplementation use, maternal age and systemic diseases and passive smoking as risk factors.

Published
2012

404. « Ces enfants maladroits » : le développement sensori-moteur des enfants nés avec une fente orofaciale

Author

Monnier, Maryline, Habersaat, Stéphanie, Bolomey, Luce, Monnier, Maryline, Habersaat, Stéphanie, and Bolomey, Luce

Abstract

La zone bucco-labiale est l’un des relais principaux de la construction de l’environnement spatial et affectif dans les premiers mois de vie. Or, dans le cas d’une naissance avec une fente orofaciale, cette zone est mise précocement à rude épreuve, risquant de provoquer un désinvestissement ou, au contraire, une hypersensibilisation pouvant entraîner un certain de nombre de conséquences à long terme. Le but de ce travail est d’investiguer le développement sensori-moteur d’enfants nés avec une fente orofaciale et de les comparer à des enfants nés sans fente, à l’âge de 5 ans. Même si aucune différence importante n’est mise en évidence, les résultats montrent quelques zones grises dans le développement sensori-moteur des enfants nés avec une fente, telles que l’articulation des différents espace entre eux, pouvant faire apparaître ces enfants comme maladroits., The orolabial area is very important in the spatial and emotional understanding of the environment in the first months of life. The birth with an orofacial cleft is accompanied with negative stimulations of this area increasing risk of developing a hyper – or hyposensitivity, with potential long term consequences. This study aims at investigating sensori-motor development at 5 years of age in children born with and without an orofacial cleft. Results did not evidence major problems in children with orofacial clefts, but rather some minor difficulties such as in the coordination of different spaces, making these children appear clumsy.

405. « Ces enfants maladroits » : le développement sensori-moteur des enfants nés avec une fente orofaciale

Author

Monnier, Maryline, Habersaat, Stéphanie, Bolomey, Luce, Monnier, Maryline, Habersaat, Stéphanie, and Bolomey, Luce

Abstract

La zone bucco-labiale est l’un des relais principaux de la construction de l’environnement spatial et affectif dans les premiers mois de vie. Or, dans le cas d’une naissance avec une fente orofaciale, cette zone est mise précocement à rude épreuve, risquant de provoquer un désinvestissement ou, au contraire, une hypersensibilisation pouvant entraîner un certain de nombre de conséquences à long terme. Le but de ce travail est d’investiguer le développement sensori-moteur d’enfants nés avec une fente orofaciale et de les comparer à des enfants nés sans fente, à l’âge de 5 ans. Même si aucune différence importante n’est mise en évidence, les résultats montrent quelques zones grises dans le développement sensori-moteur des enfants nés avec une fente, telles que l’articulation des différents espace entre eux, pouvant faire apparaître ces enfants comme maladroits., The orolabial area is very important in the spatial and emotional understanding of the environment in the first months of life. The birth with an orofacial cleft is accompanied with negative stimulations of this area increasing risk of developing a hyper – or hyposensitivity, with potential long term consequences. This study aims at investigating sensori-motor development at 5 years of age in children born with and without an orofacial cleft. Results did not evidence major problems in children with orofacial clefts, but rather some minor difficulties such as in the coordination of different spaces, making these children appear clumsy.

406. Orofacial clefts and risk factors in Tehran, Iran: A case control study

Author

Taghavi, N, Mollaian, M, Alizadeh, P, Moshref, M, Modabernia, Sh, and Akbarzadeh, A R

Subjects
Original Article, Risk factor, Iran, Orofacial cleft
Abstract

Background Non-syndromic cleft lip with or without cleft palate (CL/P) or cleft palate only (CPO) are orofacial clefts with multifactorial etiology. These include environmental factors and heterogeneous genetic background. Therefore, studies on different and homogenous populations can be useful in detecting related factors. The aim of the present study was to evaluate the risk factors in patients with non-syndromic cleft in Tehran, Iran. Methods Data from 300 patients and 300 controls were collected between 2005 and 2010. Binary logistic regression analyses were used to calculate relative risk by odds ratio (OR) and %95 confidence interval. Results Low maternal age (OR=1.06, 95% CI, 1.011-1.113), low socioeconomic status (OR=0.23, 95% CI, 0.007-0.074), maternal systemic disease (OR=0.364; 95% CI, 0.152-0.873) and passive smoking (OR=0.613, 95% CI, 0.430-0.874) increased the risk for CL/P and CPO. There was a significant difference in iron and folic acid use during pregnancy when the case and control groups were compared. Conclusion In assessing for orofacial cleft risk, we should consider lack of folic acid supplementation use, maternal age and systemic diseases and passive smoking as risk factors.

407. Recent developments in orofacial cleft genetics

Author

Marcella Martinelli, Luca Scapoli, Gregorio Laino, Rosario Rullo, Fernando Gombos, Paolo Carinci, U. Baciliero, Mauro Tognon, Francesco Carinci, Ernesto Padula, Furio Pezzetti, Fredrick Carls, Roberto Cenzi, Anna Avantaggiato, Carinci, F, Pezzetti, F, Scapoli, L, Martinelli, M, Avantaggiato, A, Carinci, P, Padula, E, Baciliero, U, Gombos, F, Laino, Gregorio, Rullo, Rosario, Cenzi, R, Carls, F, and Tognon, M.

Subjects
Genetics, business.industry, Palate, Nonsyndromic cleft, Cleft lip, Chromosome Mapping, Palatal shelves, General Medicine, Environment, Nose, Orofacial cleft, Disease Models, Animal, Epidemiologic Studies, Cleft palate, Genetic, Nasal process, Otorhinolaryngology, Medicine, Animals, Humans, Surgery, business, Gene
Abstract

Nonsyndromic cleft of the lip and/or palate (CLP or orofacial cleft) derives from an embryopathy with consequent failure of the nasal process and/or palatal shelves fusion. This severe birth defect is one of the most common malformations among live births. Nonsyndromic CLP is composed of two separate entities: cleft lip and palate (CL+/-P) and cleft palate only (CPO). Both have a genetic background, and environmental factors probably disclose these malformations. In CL+/-P, several loci have been identified, and, in one case, a specific gene has also been found. In CPO, one gene has been identified, but many more are probably involved. Because of the complexity of the genetics of nonsyndromic CLP as a result of the difference between CL+/-P and CPO, heterogeneity of each group caused by the number of involved genes, type of inheritance, and interaction with environmental factors, we discuss the more sound results obtained with different approaches: epidemiological studies, animal models, human genetic studies, and in vitro studies.

Catalog

Books, media, physical & digital resources
See catalog results