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401. The Impact of Distributed Generation Systems in the Load Forecasting

Author

Benedicto Llorens, Juan Manuel and Dias Ferreira de Jesus, José Manuel

Subjects
Electric power systems, Electric power-plants, Load, Short-Term, Enginyeria electrònica::Electrònica de potència [Àrees temàtiques de la UPC], Time Series, Centrals elèctriques, Sistemes elèctrics de potència, Regression, Forecasting, Wind Power
Abstract

Projecte fet en col.laboració amb l'Instituto Superior Tecnico. Universidade Técnica de Lisboa Load forecasting is vitally important for the electric industry in the deregulated economy. It has many applications including energy purchasing and generation, load switching, contract evaluation and infrastructure development. Because of this, a large variety of mathematical methods have been developed for load forecasting. In addition, the large-scale integration of wind power, nowadays, represents a challenge for power system operations planning, because wind power cannot be dispatched in a classical sense. Moreover, its output varies as weather conditions change. This warrants the investigation of alternative short-term power system planning methods capable of better coping with the nature of wind generation. This paper focuses on carrying out an accurate short-term load forecasting method, in a mixed scenario with uncertain wind power generation (WPG) and load, improving forecasting errors obtained with different algorithms tested. It focuses only in regression models, although other methods have already been developed, such as systems of artificial intelligence.

Published
2009

403. Sindicalismo e privatização das telecomunicações no Brasil : a busca (fracassada) a social-democracia

Author

Sávio Cavalcante, Antunes, Ricardo, 1953, Antunes, Ricardo Luis Coltro, 1953, Ranieri, Jesus José, Proni, Marcelo Weishaupt, Universidade Estadual de Campinas. Instituto de Filosofia e Ciências Humanas, and UNIVERSIDADE ESTADUAL DE CAMPINAS

Subjects
Social democracy, Socialismo, Privatisation, Sindicalismo, Telecommunication, Telecomunicações, Privatização, Syndicalism
Abstract

Orientador: Ricardo Luis Coltro Antunes Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Filosofia e Ciencias Humanas Resumo: Este trabalho tem como principal objetivo analisar a ação do movimento sindical do setor de telecomunicações contrário à privatização das companhias de telefonia brasileiras, ocorrida em 1998, sob o governo de Fernando Henrique Cardoso. O intuito foi problematizar as principais teses, pressupostos e estratégias desse grupo, assim como os da ala governista responsável pelo projeto de privatização. O SinTPq (Sindicato dos Trabalhadores de Pesquisa, Ciência e Tecnologia de Campinas e região), vinculado à FITTEL (Federação Interestadual de Trabalhadores em Telecomunicações) e à CUT (Central Única dos Trabalhadores), foi escolhido, por sua intensa atuação e elaboração de propostas, como objeto de pesquisa representativo, no geral, das posições do restante dos trabalhadores e entidades do setor em tela ligados a esse mesmo espectro político-sindical. Além da coleta de documentos, boletins, publicações e matérias de jornal, foram realizadas entrevistas com antigos e atuais diretores do sindicato citado, todos atuantes no processo de privatização. A análise da reforma privatizante das telecomunicações no Brasil pôde nos indicar que as alternativas "social-democratas", uma mera variação do conjunto de reformas neoliberais e, quanto ao segundo, a impossibilidade de renovação, ou construção, de um projeto nacional autônomo de desenvolvimento para o setor, assertivas que, grosso modo, refletem a crise das diversas formas de social-democracia em meio à transnacionalização dos capitais que caracteriza a acumulação hodierna, no geral, e das telecomunicações, em particular. O trabalho procura apontar, ainda, em linhas gerais, as principais conseqüências da privatização no que se refere aos serviços prestados e apresentar o panorama geral que marca a situação do trabalho e do sindicalismo do setor na atualidade Abstract: This study aims to analyze the action of the syndical movement of the telecommunication sector against the privatization of the Brazilian telephony company, which occurred in 1998, under Fernando Henrique Cardoso's government. The purpose was to question the main matters, implications and strategies of this groups, as well as the ones of the govern parties responsible for the privatization porject. The SinTPq (Sindicato dos Trabalhadores de Pesquisa, Ciência e Tecnologia de Campinas e região), connected to FITTEL (Federação Interestadual de Trabalhadores em Telecomunicações) and to CUT (Central Única dos Trabalhadores), was chosen, for its intense performance and creation of proposals, as representative objetct of the research, in general, of the positions of the remaining workers and entities of the sector connected to this politician-syndical specter. Besides the data collection, reports, publications and magazine reports, we interviewd old and current directors of the union, all operating in the privatization process. The analysus of the privatizating reform of the telecommunications in Brazil could indicate us that the "social-democrat" alternatives, either form the government or from the syndical movement, demonstrated, in what is related to the first, a mere variation of the set of neoliberal reforms and, for the second, the impossibility of renewal, or construction, of an independent national project of development for the sector, assuring that, grosso modo, reflects the crisis of the several ways of social-democracy transnationalization of the capitals which characterizes the modern accumulation, in general, and of the telecommunications, particularlly. The study seeks to point out, in general lines, the main consequences of the privatizations in relation to the services and to present the general panorama which marks the work situation and the unionism of the sector in the current time Mestrado Mestre em Sociologia

Published
2006

404. The species-being : an assumption in Marx's early political critique

Author

Ronaldo Crispim Sena Barros, Muller, Marcos Lutz, 1943-2020, Benoit, Alcides Hector Rodriguez, Ranieri, Jesus José, Universidade Estadual de Campinas. Instituto de Filosofia e Ciências Humanas, and UNIVERSIDADE ESTADUAL DE CAMPINAS

Subjects
Alienation (Philosophy), Gênero, Ciência política, Politics, Gender, Marx, Karl, 1818-1883, Hegel, Georg Wilhelm Friedrich, 1770-1831, Alienação (Filosofia)
Abstract

Orientador: Marcos Lutz Muller Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Filosofia e Ciencias Humanas Resumo: Trata-se do estudo do conceito de ser genérico [Gattungswesen] como pressuposto crítico da política focado na análise da Crítica da filosofia do direito de Hegel, elaborada por Karl Marx em 1843. O conceito de ser genérico ocupa um lugar de destaque no cenário teórico de Marx nas obras escritas entre os anos de 1842 a 1846 e, em grande medida, figura como um dos elementos chaves para interpretar o pensamento marxiano neste período. O alcance do estatuto da politicidade em Marx ganha amplitude quando se examina a crítica que opera a dessacralização do político na atmosfera celeste do Estado e o enraíza na vida social. O ser genérico, enquanto ser social, oferece as condições para inteligibilidade desse processo. A origem deste conceito e o papel que desempenha no sistema teórico de Marx são analisados à luz da influência de L. Feuerbach e G. W. F. Hegel. Pensadores que oferecem contribuições essenciais para o pensamento político de Marx. A atividade jornalística como redator da Gazeta Renana leva Marx a se debruçar, pela primeira vez, sobre os assim chamados interesses materiais. A conseqüência de sua nova ocupação com questões econômicas foi o rompimento com a idéia do Estado como instituição racional. O Estado figura, a partir desta nova fase, como a esfera política estranhada, desancorada da vida social, restrita a atividade estatal. Marx passa a pensar a política em dois aspectos: o negativo, como um desdobramento estranhado da vontade genérica, como alienação política, e o positivo, como ação social do homem enquanto ser genérico Abstract: This study looks at the concept of species-being [Gattungswesen] as a critical assumption underlying the politics focused upon in Marx¿s Critique of Hegel's Philosophy of Right in 1843. The concept of species-being holds the spotlight in Marx¿s theory in works written between 1842 to 1846 as well as figures substantially as one of the key elements to interpreting Marx¿s thought during this period. The influence of Marx¿s statute of politicality gains greater reach in the critique that deconsecrates politics from the sacrosanct of the State and roots it in social life. The species-being as social being propitiates conditions for intelligibility in this process. This concept¿s origin and the role that it plays in Marx¿s theoretical framework are analyzed in terms of L. Feuerbach and G.W.F. Hegel¿s influence, thinkers who offer significant contributions to Marx¿s political thought. Marx¿s journalistic activities as a writer for the Rhénane Gazette led Marx to examine for the first time so-called material interests. Resulting from his new concern with economic issues was his break with the notion of the state as a rational institution. The State emerges from now on as an estranged political sphere, disconnected with social life and restricted to state activity. Marx comes to see politics in two senses: negatively as an estranged disintegration in generic will ¿ political alienation; and positively as humanity¿s social action as species-being Doutorado Filosofia Mestre em Filosofia

Published
2006

405. Trabalho, etica e emancipação humana : da subvalorização do trabalho a sobrevalorização da etica e da politica

Author

Ronaldo Fabiano dos Santos Gaspar, Antunes, Ricardo, 1953, Lourenço, Fernando Antonio, Ranieri, Jesus José, Universidade Estadual de Campinas. Instituto de Filosofia e Ciências Humanas, Programa de Pós-Graduação em Sociologia, and UNIVERSIDADE ESTADUAL DE CAMPINAS

Subjects
Ciência política, Ética, Trabalho, Sociologia política
Abstract

Orientador: Ricardo Luiz Coltro Antunes Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Filosofia e Ciencias Humanas Resumo: As inúmeras transformações ocorridas no mundo do trabalho durante o século XX, além de terem alterado as formas de estruturação técnico-organizacional das empresas e a composição das classes trabalhadoras, também tiveram um profundo impacto sobre as teorias sociais contemporãneas, especialmente sobre o marxismo e suas variantes. Nesse sentido, são significativas as criticas que inúmeros autores, tais como Arendt, Habermas, Offe, Gorz e Méda, têm formulado a respeito da categoria trabalho em Marx e, na esteira destas, à sua proposta emancipatória, que visa a emancipação do trabalho e a necessária prescindência do Estado e do mercado como esferas de regulação social. Essencialmente, essas criticas, assentadas numa certa leitura das mutações socioeconômicas e técnico-organizacionais ocorridas no mundo do trabalho neste século, visam descaracterizar a idéia do trabalho como uma atividade central na formação subjetiva dos indivíduos e, por conseguinte, a impossibilidade de torná-Io uma atividade autônoma. Para isso, invariavelmente, reduzem o trabalho à sua dimensão técnica, procedimental, isto é, negam ou subvalorizam sua dimensão socioformativa, naturalizando as características que apresenta em sua execução sob a égide do capital. Por conta disso, esses autores apresentam propostas emancipatórias que prescindem da subversão do trabalho e que, por conseguinte, objetivam orientar as lutas sociais para a constituição de "factíveis sociedades duais", que possuem como caracteristica decisiva o controle exterior da esfera econômica. Ou seja, através de orientações gestadas e desenvolvidas discursivamente em "foros e assembléias soberanas e democráticas", o controle da esfera econômica deve ser efetuado exteriormente, pelo Estado, pela política. Enfim, apesar das inevitáveis diferenças existentes entre essas propostas emancipatórias, o politicismo, a concepção ontopositiva da política, é uma característica presente em todas elas. Portanto, através do resgate da dimensão socioformativa do trabalho, da classe trabalhadora como sujeito social da emancipação e dos limites inerentes à emancipação política, lançamos algumas dúvidas sobre a viabilidade dessas propostas Abstract: The innumerable transformations that have occurred in the world of work during the 20th century, in addition to having altered the technical-organizational structures of companies and the composition of the working classes, have also had a profound impact on contemporary social theories, especially on Marxism and its variants. In this sense, the critiques formulated by uncountable authors, including Arendt, Habermas, Offe, Gorz and Méda, are significant. These critiques are in regards to the question of work in Marx and, as an extension of this, his emancipatory proposal which has as its aim the emancipation of work and the necessary dispensability of the state and of the market as spheres of social regulation. Essentially, these critiques, based on a particular reading of the social-economic and technical-organizational mutations that took place in the world of work this century, aim to overturn the idea of work as a central activity in the subjective formation of individuais and, as a consequence, the impossibility of making it an autonomous activity. To achieve this, invariably, they reduce work to its technical, procedural dimension, that is, they deny or undervalue its social-formative dimension, categorizing the characteristics of its execution under the aegis of capital. Because of this, these authors present emancipatory proposals which do without the subversion of work and which, as a consequence, have as an objective the orientation of social battles for the constitution of "feasible duaI societies" that have as their decisive characteristic the external control of the economic sphere. In other words, through tendencies managed and developed through discussion in "sovereign and democratic forums and assemblies", the control of the economic sphere must be carried out externally, by the state and its policies. Therefore, despite the inevitable differences that exist between these emancipation proposals, the politicalness, the ontopositive conception of politics, is a characteristic common to all. 80, through the study of the social-formative dimension of work, of the working class as a social subject of the emancipation and of the inherent limits to political emancipation, we will present some doubts regarding the feasibility of these proposals Mestrado Mestre em Sociologia

Published
2001

406. Comportmental evaluation of baru (Dipteryx alata Vog.) plants in cerrados from Goiás State

Author

Corrêa, Gilmarcos de Carvalho, Zica, Lincoln Fonseca, Rodrigues, João Domingos, Jesus, José Garcia de, Garcia, Antônio Henrique, and Souza, Maurício de

Subjects
Cerrados, AGRONOMIA [CIENCIAS AGRARIAS], Dipteryx alata, Fenótipos, Baru, Savannah, Fenotipic evaluation, Avaliação
Abstract

O estudo foi conduzido com 150 plantas de baru (Dipteryx alata Vog.), 50 plantas por região, originárias de três regiões do Estado de Goiás, escolhidas, aleatoriamente, no ano de 1995. O objetivo foi verificar a ocorrência e distribuição da variabilidade genética das populações amostradas. Foram avaliados caracteres morfológicos de frutos e sementes, além de características de emergência e desenvolvimento inicial de plantas. Adotou-se, para o experimento, o modelo hierárquico com os níveis de regiões, plantas dentro de regiões e frutos dentro de plantas. Houve variação para todas as variáveis morfológicas de frutos e sementes, entre plantas de diferentes regiões, e entre plantas dentro de regiões. Não houve variação entre frutos dentro de plantas para nenhuma das variáveis avaliadas. Não houve variação entre progênies das plantas, para percentual de emergência de plantas e índice de velocidade de emergência (IVE), em qualquer dos níveis testados. As progênies apresentaram variação, entre e dentro de regiões, para velocidade de emergência em dias, e altura e diâmetro basal de plantas aos 30 dias após a emergência das mesmas. Maior proporção da variabilidade foi observada entre plantas dentro de regiões, com altos níveis de herdabilidade, no sentido amplo, para todas as variáveis estudadas. This study was carried out with 150 plants of baru (Dipteryx alata Vog.) from three regions of Goiás State. It had 50 plants per region, and it were randomizes choiced at 1995. The purpose was to verify the occurence and distribution of genetic variation among tested populations. Fruits and seeds were analysed about morphological characters. Emersion and initial development of plantas were analysed too. The experiment was planted as hierarchal model with regions level, plants within regions and fruits within plants. There was variation to all morphological characters in fruits and seeds at regions and plants within regions levels. There was no variation about plant emersion percentage and emersion velocity index (EVI). There ws variation about emersion velocity (days). Plant height and basis diameter at 30 days after emersion showed variation at regions and plants within regions levels. The most variation proportion was founded at plants within regions level with high levels of transmission to all characters.

Published
1999

407. GLIM criteria to identify malnutrition in patients in hospital settings: A systematic review.

Author

Alves LF, de Jesus JDS, Britto VNM, de Jesus SA, Santos GS, and de Oliveira CC

Subjects
Adult, Humans, Nutritional Status, Consensus, Hospitals, Nutrition Assessment, Leadership, Malnutrition diagnosis, Malnutrition epidemiology
Abstract

Malnutrition is recognized as one of the main public health problems in hospitals. The Global Leadership Initiative on Malnutrition (GLIM) has established a global consensus on the criteria for diagnosing malnutrition in adults in hospital settings. This study aimed to evaluate the ability of the GLIM criteria as a tool to identify malnutrition in hospital settings and to compare the prevalence of malnutrition identified by GLIM criteria with that identified by other screening and/or nutrition assessment methods. This was a systematic review. Searches were performed using MEDLINE/PubMed, Scopus, and Virtual Health Library, based on established descriptors. The included studies were observational and used screening and/or nutrition assessment tools to compare the prevalence of malnutrition and predictive capacity identified by GLIM criteria in patients aged >18 years in hospital settings. Twelve studies were included in this systematic review. A total of 4066 individuals with different pathologies and clinical conditions participated in the included studies. The prevalence of malnutrition, according to the GLIM criteria, ranged from 16% to 80%. In four studies, the prevalence of malnutrition based on GLIM was higher than that based on the other indicators. Six studies that evaluated the predictive ability of GLIM criteria identified satisfactory sensitivity and specificity. Four studies found low to high agreement between GLIM and the other methods. GLIM criteria can identify malnutrition and find a high prevalence and severity of malnutrition in the hospital setting, proving them to be a sensitive and specific instrument, with good agreement between screening and nutrition assessment methods., (© 2023 American Society for Parenteral and Enteral Nutrition.)

Published
2023
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408. Besifloxacin Nanocrystal: Towards an Innovative Ophthalmic Preparation.

Author

Jesus JISDS, Lourenço FR, Ishida K, Barreto TL, Avino VC, Neto EDS, and Bou-Chacra NA

Abstract

Bacterial conjunctivitis significantly impacts public health, including more than one-third of eye diseases reported worldwide. It is an infection caused by various aerobic and anaerobic bacteria and is highly contagious. Therefore, it has a high incidence of bacterial resistance to the antibiotics commonly used for treatment. Among the most recent antibiotics, besifloxacin is a fourth-generation fluoroquinolone antibiotic indicated exclusively for topical ophthalmic use. Due to its importance in treating bacterial conjunctivitis and its low solubility in water, limiting its efficacy, a nanotechnology-based drug delivery preparation was developed to overcome this hurdle. Besifloxacin nanocrystals were prepared by small-scale wet milling and response surface methodology, using Povacoat ® as a stabilizer. The particle's average hydrodynamic diameter (Z-ave) was approximately 550 nm (17 times smaller than raw material), with a polydispersity index (PdI) of less than 0.2. The saturation solubility increased about two times compared to the raw material, making it possible to increase the dissolution rate of this drug substance, potentially improving its bioavailability and safety. The optimized preparation was stable under an accelerated stability study (90 days). The Z-ave, PZ, PdI, and content did not alter significantly during this period. Furthermore, the 0.6% m/m besifloxacin nanocrystals at the maximum dose and the Povacoat ® stabilizer did not show toxicity in Galleria mellonella larvae. The innovative ophthalmic preparation minimum inhibitory concentration (MIC) was 0.0960 µg/mL and 1.60 µg/mL against Staphylococcus aureus and Pseudomonas aeruginosa , respectively, confirming in vitro efficacy. Therefore, besifloxacin nanocrystals revealed the potential for reduced dosing of the drug substance, with a minor occurrence of adverse effects and greater patient adherence to treatment.

Published
2022
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409. MAMMALS IN PORTUGAL: A data set of terrestrial, volant, and marine mammal occurrences in Portugal.

Author

Grilo C, Afonso BC, Afonso F, Alexandre M, Aliácar S, Almeida A, Alonso IP, Álvares F, Alves P, Alves PC, Alves P, Amado A, Amendoeira V, Amorim F, da Silva Aparício G, Araújo R, Ascensão F, Augusto M, Bandeira V, Barbosa AM, Barbosa S, Barbosa S, Barreiro S, Barros P, Barros T, Barros F, Basto M, Bernardino J, Bicho S, Biedma LE, Borges M, Braz L, Brito JC, Brito T, Cabral JA, Calzada J, Camarinha C, Carapuço M, Cardoso P, Carmo M, Carrapato C, da Silva Carrilho M, Carvalho DFTCS, Carvalho F, Carvalho J, Castro D, Castro G, Castro J, Castro LR, Catry FX, Cerveira AM, Cid A, Clarke R, Conde C, Conde J, Costa J, Costa M, Costa P, Costa C, do Couto AP, Craveiro J, Dias M, Dias S, Duarte B, Duro V, Encarnação C, Eufrázio S, Fael A, Falé JS, Faria S, Fernandes C, Fernandes M, da Costa GF, Ferreira C, Ferreira DF, Ferreira E, Ferreira JP, Ferreira J, Ferreira D, Fonseca C, Fontes I, Fragoso R, Franco C, Freitas T, Gabriel SI, Gibb R, Gil P, Gomes CPJ, Horta P, Gomes P, Gomes V, Grilo F, Guedes A, Guilherme F, Gutiérrez I, Harper H, Herrera JM, Hipólito D, Infante S, Jesus J, Jones KE, Laborde MI, de Oliveira LL, Leitão I, Lemos R, Lima C, Linck P, Lopes H, Lopes S, López-Baucells A, Loureiro A, Loureiro F, Lourenço R, Lourenço S, Lucas P, Magalhães A, Maldonado C, Marcolin F, Marques S, Marques JT, Marques C, Marques P, Marrecas PC, Martins F, Martins R, Mascarenhas M, Mata VA, Mateus AR, Matos M, Medinas D, Mendes T, Mendes G, Mestre F, Milhinhas C, Mira A, Monarca RI, Monteiro N, Monteiro B, Monterroso P, Nakamura M, Negrões N, Nóbrega EK, Nóvoa M, Nunes M, Nunes NJ, Oliveira F, Oliveira JM, Palmeirim JM, Pargana J, Paula A, Paupério J, Pedroso NM, Pereira G, Pereira PF, Pereira J, Pereira MJR, Petrucci-Fonseca F, Pimenta M, Pinto S, Pinto N, Pires R, Pita R, Pontes C, Quaresma M, Queirós J, Queirós L, Rainho A, da Graça Ramalhinho M, Ramalho P, Raposeira H, Rasteiro F, Rebelo H, Regala FT, Reto D, Ribeiro SB, Rio-Maior H, Rocha R, Rocha RG, Rodrigues L, Román J, Roque S, Rosalino LM, do Rosário IT, Rossa M, Russo D, Sá P, Sabino-Marques H, Salgueiro V, Santos H, Santos J, Santos JPV, Santos N, Santos S, Santos CP, Santos-Reis M, Serronha A, Sierra P, Silva B, Silva CSGM, Silva C, Silva D, da Silva LP, Silva R, Silva C, da Silva Júnior FMR, Sousa P, Sousa-Guedes D, Spadoni G, Tapisso JT, Teixeira D, Teixeira S, Teixeira N, Torres RT, Travassos P, Vale-Gonçalves H, Cidraes-Vieira N, von Merten S, and da Luz Mathias M

Subjects
Animals, Climate Change, Mammals, Portugal, Rabbits, Rodentia, Carnivora, Ecosystem
Abstract

Mammals are threatened worldwide, with ~26% of all species being included in the IUCN threatened categories. This overall pattern is primarily associated with habitat loss or degradation, and human persecution for terrestrial mammals, and pollution, open net fishing, climate change, and prey depletion for marine mammals. Mammals play a key role in maintaining ecosystems functionality and resilience, and therefore information on their distribution is crucial to delineate and support conservation actions. MAMMALS IN PORTUGAL is a publicly available data set compiling unpublished georeferenced occurrence records of 92 terrestrial, volant, and marine mammals in mainland Portugal and archipelagos of the Azores and Madeira that includes 105,026 data entries between 1873 and 2021 (72% of the data occurring in 2000 and 2021). The methods used to collect the data were: live observations/captures (43%), sign surveys (35%), camera trapping (16%), bioacoustics surveys (4%) and radiotracking, and inquiries that represent less than 1% of the records. The data set includes 13 types of records: (1) burrows | soil mounds | tunnel, (2) capture, (3) colony, (4) dead animal | hair | skulls | jaws, (5) genetic confirmation, (6) inquiries, (7) observation of live animal (8), observation in shelters, (9) photo trapping | video, (10) predators diet | pellets | pine cones/nuts, (11) scat | track | ditch, (12) telemetry and (13) vocalization | echolocation. The spatial uncertainty of most records ranges between 0 and 100 m (76%). Rodentia (n =31,573) has the highest number of records followed by Chiroptera (n = 18,857), Carnivora (n = 18,594), Lagomorpha (n = 17,496), Cetartiodactyla (n = 11,568) and Eulipotyphla (n = 7008). The data set includes records of species classified by the IUCN as threatened (e.g., Oryctolagus cuniculus [n = 12,159], Monachus monachus [n = 1,512], and Lynx pardinus [n = 197]). We believe that this data set may stimulate the publication of other European countries data sets that would certainly contribute to ecology and conservation-related research, and therefore assisting on the development of more accurate and tailored conservation management strategies for each species. There are no copyright restrictions; please cite this data paper when the data are used in publications., (© 2022 The Authors. Ecology © 2022 The Ecological Society of America.)

Published
2022
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410. Pregnancy Outcomes and Child Development Effects of SARS-CoV-2 Infection (PROUDEST Trial): Protocol for a Multicenter, Prospective Cohort Study.

Author

Fernandes GM, Motta F, Sasaki LMP, Silva ÂPD, Miranda AM, Carvalho AO, Gomides APM, Soares AASM, Santos ACMD Jr, Alves CO, Gomes CM, Siracusa CC, Araújo DA Jr, Mendonça-Silva DL, Jesus JAL, Costa KN, Castro MEC, Kurizky PS, França PS, Tristão R, Pereira YR, Castro LCG, Zaconeta AM, Albuquerque CP, and Mota LMHD

Abstract

Background: A growing body of evidence suggests that SARS-COV-2 infection during pregnancy may affect maternal-fetal outcomes and possibly result in implications for the long-term development of SARS-CoV-2-exposed children., Objective: The PROUDEST (Pregnancy Outcomes and Child Development Effects of SARS-CoV-2 Infection Study) is a multicenter, prospective cohort study designed to elucidate the repercussions of COVID-19 for the global health of mothers and their children., Methods: The PROUDEST trial comprises 2 prospective, sequential substudies. The PREGNANT substudy will clinically assess the effects of SARS-CoV-2 infection on pregnancy, childbirth, and puerperium from a mechanistic standpoint to elucidate the pregnancy-related inflammatory and immunological phenomena underlying COVID-19. Pregnant women aged 18-40 years who have been exposed (proven with laboratory tests) to SARS-CoV-2 (group A; n=300) will be compared to control subjects with no laboratory evidence of in-pregnancy exposure to the virus (group B; n=300). Subjects exposed to other infections during pregnancy will be excluded. The BORN substudy is a long-term follow-up study that will assess the offspring of women who enrolled in the prior substudy. It will describe the effects of SARS-CoV-2 exposure during pregnancy on children's growth, neurodevelopment, and metabolism from birth up to 5 years of age. It includes two comparison groups; group A (exposed; n=300) comprises children born from SARS-CoV-2-exposed pregnancies, and group B (controls; n=300) comprises children born from nonexposed mothers., Results: Recruitment began in July 2020, and as of January 2021, 260 pregnant women who were infected with SARS-CoV-2 during pregnancy and 160 newborns have been included in the study. Data analysis is scheduled to start after all data are collected., Conclusions: Upon completion of the study, we expect to have comprehensive data that will provide a better understanding of the effects of SARS-CoV-2 infection and related inflammatory and immunological processes on pregnancy, puerperium, and infancy. Our findings will inform clinical decisions regarding the care of SARS-CoV-2-exposed mothers and children and support the development of evidence-based public health policies., Trial Registration: Brazilian Register of Clinical Trials RBR65QXS2; https://ensaiosclinicos.gov.br/rg/RBR-65qxs2., International Registered Report Identifier (irrid): DERR1-10.2196/26477., (©Geraldo Magela Fernandes, Felipe Motta, Lizandra Moura Paravidine Sasaki, Ângelo Pereira Da Silva, Andreza Monforte Miranda, Aleida Oliveira De Carvalho, Ana Paula Monteiro Gomides, Alexandre Anderson De Sousa Munhoz Soares, Agenor De Castro Moreira Dos Santos Jr, Caroline De Oliveira Alves, Ciro Martins Gomes, Clara Correia De Siracusa, David Alves De Araújo Jr, Dayde Lane Mendonça-Silva, José Alfredo Lacerda De Jesus, Karina Nascimento Costa, Maria Eduarda Canellas De Castro, Patricia Shu Kurizky, Paulo Sérgio França, Rosana Tristão, Yacara Ribeiro Pereira, Luiz Claudio Gonçalves De Castro, Alberto Moreno Zaconeta, Cleandro Pires De Albuquerque, Licia Maria Henrique Da Mota. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 20.04.2021.)

Published
2021
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411. Raman Spectroscopy for Quantitative Analysis in the Pharmaceutical Industry.

Author

Jesus JISDS, Löbenberg R, and Bou-Chacra NA

Subjects
Drug Industry, Nanostructures analysis, Pharmaceutical Preparations analysis, Spectrum Analysis, Raman
Abstract

Raman spectroscopy is a very promising technique increasingly used in the pharmaceutical industry. Due to its development and improved instrumental versatility achieved over recent decades and through the application of chemometric methods, this technique has become highly precise and sensitive for the quantification of drug substances. Thus, it has become fundamental in identifying critical variables and their clinical relevance in the development of new drugs. In process monitoring, it has been used to highlight in-line real-time analysis, and it has been used more commonly since 2004 when the Food and Drug Administration (FDA) launched Process Analytical Technology (PAT), integrated with the concepts of Pharmaceutical Current Good Manufacturing Practices (CGMPs) for the 21st Century. The present review presents advances in the application of this tool in the development of pharmaceutical products and processes in the last six years.

Published
2020
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412. Obstructive sleep apnoea in patients with fibrotic diffuse parenchymal lung disease-characterization and treatment compliance assessment.

Author

Cardoso AV, Pereira N, Neves I, Santos V, Jesus JM, Melo N, Mota PC, Morais A, and Drummond M

Abstract

Introduction: Recent studies have reported a high prevalence of obstructive sleep apnoea (OSA) among patients with diffuse parenchymal lung disease (DPLD), mainly idiopathic pulmonary fibrosis (IPF). Effective OSA treatment appears to have a positive impact on morbidity and mortality in these patients. However, poor compliance to positive airway pressure (PAP) treatment in fibrotic DPLD patients has been reported. The aims of our study were to characterize patients with fibrotic DPLD and OSA and to assess their compliance to PAP treatment., Methods: Forty-nine patients with fibrotic DPLD underwent level III polysomnography. Auto-adjusting PAP (APAP) treatment was proposed for those patients with moderate-to-severe OSA and those with mild OSA with daytime sleepiness and/or cardiovascular disease. The APAP treatment compliance was assessed after 1 month of therapy., Results: The distribution of the 49 fibrotic DPLD patients included was as follows: 21 with chronic hypersensitivity pneumonitis, 12 with IPF, 10 with connective-tissue associated DPLD, 4 with stage IV sarcoidosis, 1 with idiopathic pleuropulmonary fibroelastosis, and 1 with DPLD-associated vasculitis. Thirty-four (69.4%) of the patients presented with OSA; 22 had mild OSA, and 12 had moderate-to-severe OSA. APAP treatment was prescribed in 17 of the patients. After 1 month of therapy, all patients used APAP more than 70% of the nights for more than 4 h per night., Conclusion: We found a high prevalence of OSA among all of the patients with fibrotic DPLD (not only IPF). Despite certain difficulties, it was possible to achieve good APAP compliance in these patients.

Published
2018
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413. Complete dorsal pancreatic agenesis and unilateral renal agenesis.

Author

Moreira A, Carvalho A, Portugal I, and Jesus JM

Abstract

Dorsal pancreatic agenesis is a very rare congenital anomaly. Unilateral renal agenesis, on the other hand, is a relatively common congenital anomaly, although its etiology is not fully understood. Renal and pancreatic embryologic development appears to be nonrelated. We report a case of a 34-year-old man who was referred to our hospital for evaluation of cholestasis and microalbuminuria. Ultrasound and magnetic resonance imaging examinations showed empty right renal fossa and absence of the pancreatic neck, body, and tail. Our case report is the second case of a dorsal pancreatic agenesis and unilateral renal agenesis in a young male patient.

Published
2017
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414. Transanal minimally invasive surgery for total mesorectal excision (ETM) through transanal approach (TaETM) with robotic and Transanal Endoscopic Operations (TEO) combined access: step by step surgery.

Author

Mendes CR, Valadão M, Araújo R, Linhares E, and Jesus JP

Subjects
Anal Canal, Digestive System Surgical Procedures methods, Female, Humans, Middle Aged, Minimally Invasive Surgical Procedures methods, Natural Orifice Endoscopic Surgery methods, Rectal Neoplasms surgery, Robotic Surgical Procedures methods
Abstract

Rational: In the treatment of colorectal cancer, from 1982 Heald proposed standardization of the total mesorectal excision, with a significant reduction in the recurrence rate. But the treatment of lower rectal lesions is still a challenge., Aim: To describe the association of robotic low anterior resection- TATA (Transanal Abdominal Transanal Resection), with transanal access using Transanal Endoscopic Operations - TEO in the treatment of lower rectal cancer., Method: The TATA performs robotic abdominal approach and the TEO performs the perineal approach, developing total mesorectal excision (TME) transanally (TaETM)., Result: The TaETM technique was applied in a woman with rectal adenocarcinoma 5 cm from the anal verge that had been submitted to chemoradiation. The procedure was performed with satisfatory operative time and favorable oncological outcome (grade 3 mesorectal excision)., Conclusion: This is a promising minimally invasive procedure in the armamentarium of rectal cancer treatment, specially in challenging scenarios such as narrow pelvis, obesity and very low rectal tumors.

Published
2015
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415. Brazilian consensus in gastric cancer: guidelines for gastric cancer in Brazil.

Author

Zilberstein B, Malheiros C, Lourenço LG, Kassab P, Jacob CE, Weston AC, Bresciani CJ, Castro O, Gama-Rodrigues J, Borin AA, Buchpiegel C, Montagnini A, Leite CV, Deutsch CR, Kruel CD, Mucerino D, Wohnrath D, Ilias E, Mrué F, Maluf-Filho F, Rocha F, de Souza F, Tomasich FS, Ishak G, Laporte G, de Souza HP, Cecconello I, Eisig J, Ohana J, Sabagga J, del Grande JC, de Jesus JP, Soares J, Dias LA, Moreira LF, Correa M, Carvalho M, Andreollo NA, Áquila ND, Czeczko NG, Kruel N, Forones NM, da Motta OM, Malafaia O, Assumpção P, Leonardi P, Sakai P, Rocha PR, Colleoni R, Gurgel R, Coral RP, Chalub S, Ribeiro- Junior U, Alves VA, Vasquez Vde L, and Nadalin V

Subjects
Brazil, Humans, Stomach Neoplasms diagnosis, Stomach Neoplasms therapy
Abstract

Background: In Brazil, gastric cancer is the fourth most common malignancy among men and sixth among women. The cause is multivariate and the risks are well known. It has prognosis and treatment defined by the location and staging of the tumor and number of lymph nodes resected and involved., Aim: The Brazilian Consensus on Gastric Cancer promoted by ABCG was designed with the intention to issue guidelines that can guide medical professionals to care for patients with this disease., Methods: Were summarized and answered 43 questions reflecting consensus or not on diagnosis and treatment that may be used as guidance for its multidisciplinary approach. The method involved three steps. Initially, 56 digestive surgeons and related medical specialties met to formulate the questions that were sent to participants for answers on scientific evidence and personal experience. Summaries were presented, discussed and voted in plenary in two other meetings. They covered 53 questions involving: diagnosis and staging (six questions); surgical treatment (35 questions); chemotherapy and radiotherapy (seven questions) and anatomopathology, immunohistochemistry and perspective (five questions). It was considered consensus agreement on more than 70% of the votes in each item., Results: All the answers were presented and voted upon, and in 42 there was consensus., Conclusion: It could be developed consensus on most issues that come with the care of patients with gastric cancer and they can be transformed in guidelines.

Published
2013
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416. Colon and rectum neuroendocrine tumors: experience of the National Cancer Institute in Brazil.

Author

Cesar D, Zanatto RM, da Silva MV, Golçalves R, de Mello EL, and de Jesus JP

Subjects
Academies and Institutes, Adult, Aged, Algorithms, Brazil, Female, Humans, Male, Middle Aged, Young Adult, Colonic Neoplasms diagnosis, Colonic Neoplasms surgery, Neuroendocrine Tumors, Rectal Neoplasms diagnosis, Rectal Neoplasms surgery
Abstract

Background: Neuroendocrine tumors (NETs) are rare, comprising nearly 0.49% of all malignancies. The majority occurs in the gastrointestinal tract., Aim: To analyze the demographic factors, clinicopathologic features, treatment employed, prognostic factors and the oncologic results related to colorectal NETs., Methods: Between the period from 1996 to 2010 174 patients were treated. From these, 34 were localized in the colon and rectum. Demographic factors, stage, therapeutics and its results were analyzed. All patients were followed for more than three years with image exams, urinary 5-hydroxyindolacetic acid (5-HIIA), serum chromogranin A and prostatic acid phosphatase., Results: The median age was 54,4 years (22-76), the majority was female (64,7%). Out of the 12 patients with colon NETs, one (8.3%) patient was classified as Stage IA; one (8.3%) as Stage IB; three (25%) as Stage IIIB and seven (58.4%) as Stage IV. Out of the 22 patients with rectum NETs, six (27.3%) were classified as Stage IA; four (18.2%) as IB; three (13.6 %) as IIIA; one (4.5%) as IIIB and eight (36.4%) as IV. Of rectal NETs, nine (41%) were treated with endoscopic resection, six (27.2%) underwent conventional surgical treatment and six (27.2%) were treated with chemotherapy. Eleven patients with colon NETs (91.6%) were surgically treated, seven of them with palliative surgery, one (8.4%) was treated with endoscopic resection and no patient was submitted to chemotherapy. After an average follow-up of 55 months, 19 (55%) patients were alive. Analyzing the overall survival was obtained an average overall survival of 29 months in Stage IA, 62 months in IB, 12 months in IIIA, 31 months in IIIB and 39 months in IV., Conclusion: The treatment of colon and rectal NETs is complex, because it depends of the individuality of each patient. With adequate management, the prognosis can be favorable with long survival, but it is related to the tumor differentiation degree, efficacy of the chosen treatment and to the patient adhesion to the follow-up after treatment.

Published
2013
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417. Gastrointestinal stromal tumor: analysis of 146 cases of the center of reference of the National Cancer Institute--INCA.

Author

Linhares E, Gonçalves R, Valadão M, Vilhena B, Herchenhorn D, Romano S, Ferreira MA, Ferreira CG, Ramos Cde A, and de Jesus JP

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Cancer Care Facilities, Child, Female, Humans, Male, Middle Aged, Retrospective Studies, Young Adult, Gastrointestinal Stromal Tumors diagnosis, Gastrointestinal Stromal Tumors surgery
Abstract

Objective: To evaluate the treatment of GIST in INCA., Methods: We conducted a retrospective analysis of all cases of GIST treated at INCA in the period from 1997 to 2009., Results: We analyzed 146 patients with a mean age of 44.5 years and female predominance. The main symptom was abdominal pain. We observed the occurrence of a second primary tumor in 22% of cases and 92% of the immunohistochemistry exams were positive for CD117. The most frequent location was in the stomach and the high-risk group was predominant. Surgery was considered R0 (extensive) in 70% of the cases and the main sites of metastases were liver and peritoneum. Overall survival in two and five years was, respectively, 86% and 59%. There was a significant difference between overall survival (p = 0.29) of the high-risk group versus the other., Conclusion: Our patients presented mainly in the form of high-risk disease, with obvious impact on survival. The use of imatinib improved survival of patients with recurrent and metastatic disease. We should study its use in the setting of adjuvant and neoadjuvant therapy to improve results of the high risk group. The creation of reference centers is a need for the study of rare diseases.

Published
2011
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418. An ectonucleotide ATP-diphosphohydrolase activity in Trichomonas vaginalis stimulated by galactose and its possible role in virulence.

Author

de Jesus JB, de Sá Pinheiro AA, Lopes AH, and Meyer-Fernandes JR

Subjects
Animals, Calcium Chloride pharmacology, Chlorides pharmacology, Enzyme Activation, Kinetics, Magnesium Chloride pharmacology, Ribonucleotides metabolism, Substrate Specificity, Zinc Compounds pharmacology, Adenosine Triphosphatases metabolism, Apyrase metabolism, Galactose pharmacology, Trichomonas vaginalis enzymology, Trichomonas vaginalis pathogenicity
Abstract

This work describes the ability of living Trichomonas vaginalis to hydrolyze extracellular ATP (164.0 +/- 13.9 nmol Pi/h x 10(7) cells). This ecto-enzyme was stimulated by ZnCl2, CaCl2 and MgCl2, was insensitive to several ATPase and phosphatase inhibitors and was able to hydrolyze several nucleotides besides ATP. The activity was linear with cell density and with time for at least 60 min. The optimum pH for the T. vaginalis ecto-ATPase lies in the alkaline range. D-galactose, known to be involved in adhesion of T. vaginalis to host cells, stimulated this enzyme by more than 90%. A comparison between two strains of T. vaginalis showed that the ecto-ATPase activity of a fresh isolate was twice as much as that of a strain axenically maintained in culture, through daily passages, for several years. The results suggest a possible role for this ecto-ATPase in adhesion of T. vaginalis to host cells and in its pathogenicity.

Published
2002
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